Search Result

Results for "

AMPK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (224) Acetyl-CoA Carboxylase (4) ADC Payload (3) Adenosine Receptor (2) Adiponectin Receptor (1) Adrenergic Receptor (4) Akt (23) Amyloid-β (2) Androgen Receptor (1) Annexin A (1) Antibiotic (3) AP-1 (1) Apoptosis (57) Atg8/LC3 (1) ATP Citrate Lyase (4) Aurora Kinase (3) Autophagy (71) Bacterial (23) Bcl-2 Family (7) Beclin1 (2) Beta-secretase (2) Biochemical Assay Reagents (3) c-Met/HGFR (1) Calcium Channel (6) Calmodulin (1) CaMK (2) Cannabinoid Receptor (1) Caspase (5) Checkpoint Kinase (Chk) (1) Chloride Channel (6) Cholinesterase (ChE) (5) COX (8) Cytochrome P450 (1) Deubiquitinase (1) DNA/RNA Synthesis (1) Drug Metabolite (1) E1/E2/E3 Enzyme (1) EGFR (3) Endogenous Metabolite (21) Ephrin Receptor (2) ERK (5) FLT3 (1) Fluorescent Dye (1) Fungal (4) GLUT (3) GSK-3 (1) HBV (3) HDAC (4) HIF/HIF Prolyl-Hydroxylase (1) Hippo (MST) (1) HIV (6) HSP (1) IKK (1) Influenza Virus (1) Insecticide (3) Insulin Receptor (1) Interleukin Related (8) Isotope-Labeled Compounds (20) JAK (2) JNK (5) Keap1-Nrf2 (12) Kinesin (1) MAPKAPK2 (MK2) (1) MARK (2) MDM-2/p53 (3) Microtubule/Tubulin (1) Mitochondrial Metabolism (11) Mitophagy (16) MMP (4) mTOR (18) NAMPT (1) NF-κB (17) NO Synthase (5) NOD-like Receptor (NLR) (3) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (3) Organoid (3) Oxidative Phosphorylation (5) P2Y Receptor (1) p38 MAPK (8) Parasite (27) PARP (5) PERK (3) PGC-1α (1) Phosphatase (1) PI3K (7) Pim (1) PKA (4) PKC (2) Potassium Channel (8) PPAR (23) Pyroptosis (4) Pyruvate Kinase (1) Quinone Reductase (1) Reactive Oxygen Species (ROS) (15) Reference Standards (46) ROS Kinase (4) Salt-inducible Kinase (SIK) (5) SARS-CoV (6) Ser/Thr Kinase (1) SGLT (2) Sirtuin (6) Small Interfering RNA (siRNA) (4) SOD (4) Src (1) STAT (4) Survivin (2) TGF-beta/Smad (1) TGF-β Receptor (4) TNF Receptor (8) Toll-like Receptor (TLR) (1) Topoisomerase (3) TRP Channel (2) Tyrosinase (2) ULK (1) VEGFR (1) Virus Protease (2) Wnt (2) YAP (5) β-catenin (1)
By Research Areas:	Cancer (127) Cardiovascular Disease (42) Endocrinology (4) Infection (43) Inflammation/Immunology (58) Metabolic Disease (149) Neurological Disease (40)
Oligonucleotides:	Nucleosides and their Analogs (1) Rat Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (3) Cholesterol (1) siRNAs (4)

306

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

106

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: AMPK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2952

Myokinase, Microorganism AMPK; Myokinase; Adk	Endogenous Metabolite	Others
Adenylate (Adk), i.e., myokinase, is a phosphotransferase enzyme, is often used in biochemical studies. Adenylate catalyzes the interconversion of adenosine phosphates. Adenylate monitors phosphate nucleotide levels inside the cell, it plays an important role in cellular energy homeostasis .

HY-151361

AMPK-IN-3 3 Publications Verification	AMPK	Cancer
AMPK-IN-3 (compound 67) is a potent and selective *AMPK* inhibitor with IC₅₀s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits *AMPK* does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer .

HY-155363

AMPK activator 13	AMPK	Metabolic Disease
AMPK activator 13 is a potent activator of *AMPK. AMPK* activator 13 inhibits mitotic clonal expansion of 3T3-L1 cells by activating AMPK pathway and enhances cell mitochondrial oxygen consumption rate. AMPK activator 13 can be used in study obesity .

HY-130155

AMPK activator C2	AMPK	Neurological Disease
AMPK activator C2 is a potent allosteric *AMPK* activator that is promising for research of epilepsy and convulsions .

HY-170931

AMPK activator 16	AMPK Acetyl-CoA Carboxylase	Neurological Disease Metabolic Disease
AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells .

HY-154973

AMPK activator 11	Oxidative Phosphorylation Mitochondrial Metabolism AMPK	Metabolic Disease Cancer
AMPK activator 11 is an AMP-activated protein kinase (AMPK) activator with nanomolelevel antiproliferation activities against several CRCs. AMPK activator 11 selectively inhibits the RKO xenograft growth along by activating AMPK and upregulating oxidative phosphorylation (OXPHOS) ( mitochondrial metabolism ) and can be used for anti-tumor and metabolic disease research .

HY-147037

AMPK activator 7	AMPK	Cardiovascular Disease Metabolic Disease
AMPK activator 7 (compound I-3-24) is a an *AMPK* activator with the EC₅₀ of 8.8 nM. AMPK activator 7 can be used for the research of diseases involving AMPK, particularly diseases such as type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia and/or hypertension .

HY-146398

AMPK activator 6	AMPK	Metabolic Disease
AMPK activator 6 (Compound GC) reduces lipid content and activates the AMPK pathway in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase in triglyceride (TG) , total cholesterol (TC), low-density lipoprotein-C (LDL-C), and other biochemical indices in blood serum. AMPK activator 6 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome .

HY-147038

AMPK activator 8	AMPK	Metabolic Disease
AMPK activator 8 (compound 2) is an AMP-activated protein kinase (AMPK) activator with EC₅₀s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes .

HY-172094

AMPK-IN-6	AMPK Apoptosis Autophagy	Cardiovascular Disease
AMPK-IN-6 (compound 13a) is potent *AMPK* inhibitor with an IC₅₀ value of 0.093 µM. AMPK-IN-6 induces apoptosis and inhibits autophagy. AMPK-IN-6 shows antiproliferative activity. AMPK-IN-6 has the potential for the research of pulmonary arterial hypertension .

HY-168639

AMPK activator 15	Mitochondrial Metabolism AMPK	Metabolic Disease
AP39 prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. AP39 prodrug 1 induces ROS-dependent mild mitochondrial uncoupling, activating mitochondria-associated AMPK to suppress Palmitic acid (PA) (HY-N0830)-induced lipid deposition in hepatocytes .

HY-155943

AMPK-IN-4	AMPK	Cancer
AMPK-IN-4 (compound 19) is a potent inhibitor of (AMPK(α1) and *AMPK*(α2) with IC₅₀s of 393 nM and 141 nM, respectively. AMPK-IN-4 plays an important role in cancer research .

HY-120904

AMPK-IN-1	AMPK	Metabolic Disease
AMPK-IN-1 is an activator of *AMPK* (EC₅₀: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way .

HY-148684

AMPK activator 10	AMPK	Metabolic Disease
AMPK activator 10 is an orally active, potent *AMPK* activator with EC₁₅₀ of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect .

HY-172901

AMPK activator 17	AMPK	Cardiovascular Disease Metabolic Disease
AMPK activator 17 (Compound 10g) is an orally active *AMPK* activator. AMPK activator 17 has significant anti-adipogenic (IC₅₀: 3.4 μM) and dyslipidemia-modifying activities. AMPK activator 17 inhibits the early stages of adipocyte differentiation (mitotic clonal expansion) by activating the AMPK pathway. AMPK activator 17 can enhance mitochondrial function and fatty acid oxidation in mature adipocytes. AMPK activator 17 improves dyslipidemia by promoting reverse cholesterol transport. AMPK activator 17 can be used in the study of obesity and related metabolic diseases (such as type 2 diabetes and cardiovascular disease) .

HY-131334

AMPK activator 4	AMPK	Metabolic Disease
AMPK activator 4 is a potent *AMPK* activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect .

HY-149406

AMPK activator 12	AMPK	Cancer
AMPK activator 12 (compound 21) is a potent *AMPK* activator and GDF15 inducer. AMPK activator 12 increases GDF15 protein levels in human hepatic cells .

HY-162042

AMPK activator 14	AMPK	Metabolic Disease
AMPK activator 14 (compound 32) is an orally active *AMPK* activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes .

HY-148210

AMPK activator 9	AMPK	Metabolic Disease
AMPK activator 9 (ZM-6) is a potent AMPK (α2β1γ1) activator with an EC₅₀ value of 1.1 µM. AMPK activator 9 has the potential for the research of type 2 diabetes .

HY-U00292

AMPK activator 1	AMPK	Metabolic Disease
AMPK activator 1 is an *AMPK* activator extracted from patent WO2013116491A1, compound No.1-75, has an EC₅₀ of <0.1μM.

HY-130723

AMPK activator 2	AMPK	Cancer
AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates *AMPK* signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

HY-130723A

AMPK activator 2 hydrochloride	AMPK	Cancer
AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates *AMPK* signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

HY-162317

AMPK-IN-5	JAK p38 MAPK	Infection
AMPK-IN-5 (compound 7m) is a Osthole (HY-N0054) derivative, and blocks MAPK signal transduction by inhibiting the phosphorylation of JNK and p38, thereby inhibiting the release of inflammatory cytokines. AMPK-IN-5 reduce DSS-induced ulcerative colitis and LPS (HY-D1056)-induced acute lung injury .

HY-157129

AMPK-α1β1γ1 activator 1	AMPK	Cardiovascular Disease
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC₅₀ value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy .

HY-12831

Ampkinone 3 Publications Verification	AMPK	Metabolic Disease
Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.

HY-155967

*CB1R/AMPK* modulator 1**	AMPK Cannabinoid Receptor	Metabolic Disease
CB1R/AMPK modulator 1 (Compound 38-S) is an orally active *CB1R/AMPK* modulator, with an K_i of 0.81 nM and an IC₅₀ of 3.9 nM for CB1R. CB1R/AMPK modulator 1 activates AMPK. CB1R/AMPK modulator 1 reduces food intake and body weight, and improves glucose tolerance and insulin sensitivity .

HY-N9349

Malvidin-3-O-arabinoside chloride 1 Publications Verification	AMPK Autophagy	Metabolic Disease Inflammation/Immunology
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy .

HY-117623

PF-06685249 PF-249	AMPK	Metabolic Disease
PF-06685249 (PF-249) is a potent and orally active allosteric *AMPK* activator with an EC₅₀ of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research .

HY-120877A

(R)-MRT199665	MARK Salt-inducible Kinase (SIK) AMPK Apoptosis	Cancer
(R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective *MARK/SIK/AMPK* inhibitor with IC₅₀s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 .

HY-N4253

Kudinoside D 1 Publications Verification	Others	Metabolic Disease
Kudinoside D is a main natural component of triterpenoid saponin derived from Ilex kudingcha. Kudinoside D suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes .

HY-P0136F

FAM-SAMS	AMPK	Others
FAM-SAMS is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

HY-P0136AF

FAM-SAMS TFA	Fluorescent Dye	Others
FAM-SAMS TFA is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

HY-50662

A-769662 35+ Cited Publications	AMPK	Metabolic Disease
A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC₅₀ = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC₅₀ = 3.2 μM). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes .

HY-N11924

Foenumoside B	AMPK PPAR	Metabolic Disease
Foenumoside B is a triterpene saponin isolated from Lysimachia foenum-graecum. Foenumoside B activates *AMPK* signaling, inhibits PPARγ-induced adipogenesis, and shifts lipid metabolism toward lipolysis. Foenumoside B can be used in the study of obesity and obesity-related metabolic diseases .

HY-169566

EGFR-IN-146	EGFR AMPK	Metabolic Disease
EGFR-IN-146 is an EGFR inhibitor that can inhibit the EGFR signaling pathway and improve insulin sensitivity by activating the AMPK pathway, which can effectively reduce blood sugar levels and body weight. EGFR-IN-146 has great potential in the study of diabetes and obesity .

HY-174157

AR493	Autophagy AMPK	Neurological Disease Metabolic Disease
AR493 is an autophagy activator acting on *AMPK* (adenosine monophosphate-activated protein kinase). AR493 regulates pathways related to cellular energy sensing and increases autophagy levels. AR493 is promising for research of aging-associated diseases (such as diabetes, neurodegenerative diseases) and autophagy regulation .

HY-103238

RSVA405 1 Publications Verification	AMPK STAT Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology
RSVA405 is a potent, orally active activator of *AMPK, with an EC₅₀* of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity .

HY-124822

COH-SR4 2 Publications Verification	AMPK	Metabolic Disease Cancer
COH-SR4 is an *AMPK* activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders .

HY-N6077

Thalidezine	AMPK Apoptosis	Cancer
Thalidezine is a novel activator of AMP-activated protein kinase (AMPK). Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention .

HY-A0144A

Etilefrine hydrochloride	Adrenergic Receptor AMPK Akt	Cardiovascular Disease
Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the *AMPK/Akt* pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-A0144

Etilefrine	Adrenergic Receptor AMPK Akt	Cardiovascular Disease
Etilefrine is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine also bidirectionally regulates the *AMPK/Akt* pathway and modulates the phosphorylation levels. Etilefrine can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-162516

DBI-2	AMPK Mitochondrial Metabolism	Cancer
DBI-2 is an *AMPK* activator targeting mitochondrial complex I. DBI-2 disrupts the OXPHOS process, and reduces ATP generation in mitochondria. DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells .

HY-141543

YW2065	β-catenin	Cancer
YW2065 is an Axin-1 stabilizer. Axin-1 is a scaffolding protein that regulates proteasome degradation of β-catenin. YW2065 exhibits anti-colorectal cancer effects via dual activities of wnt/β-catenin signaling inhibition and *AMPK* activation .

HY-W017212

Methyl cinnamate 2 Publications Verification Methyl 3-phenylpropenoate	Tyrosinase Bacterial AMPK	Infection Metabolic Disease
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the *CaMKK2-AMPK* signaling pathway .

HY-A0144R

Etilefrine (Standard)	Adrenergic Receptor AMPK Akt	Cardiovascular Disease
Etilefrine (Standard) is the analytical standard of Etilefrine. This product is intended for research and analytical applications. Etilefrine is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-A0144AR

Etilefrine hydrochloride (Standard)	Reference Standards AMPK Adrenergic Receptor Akt	Cardiovascular Disease
Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the *AMPK/Akt* pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-W011012

Adenosine 5'-monophosphate disodium 10+ Cited Publications	Adenosine Receptor	Metabolic Disease
Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-W013816

Dipentyl phthalate	AMPK Akt	Metabolic Disease
Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant .

HY-P10367

Ziptide	MAPKAPK2 (MK2) Checkpoint Kinase (Chk) AMPK	Others
Ziptide is a substrate for MAPK activated protein kinase 2 (MAPKAPK2, K_m = 5 μM), MAPKAPK3 (K_m = 30 μM), PARK (K_m = 40 μM), checkpoint kinase 1 (Chk1, K_m = 5 μM), AMP-activated protein kinase (AMPK, K_m = 75 μM), and calcium/calmodulin-dependent protein kinase II (CamKII, K_m = 300 μM) .

HY-N7676

Marein 2 Publications Verification	AMPK HDAC	Cardiovascular Disease Neurological Disease Metabolic Disease
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .

Cat. No.	Product Name

HY-L040

Anti-diabetic Compound Library

917 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 917 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

HY-L034

Anti-Aging Compound Library

5,983 compounds

Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

MCE Anti-Aging Compound Library contains 5,983 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

HY-L037

Antioxidant Compound Library

1,857 compounds

Oxidative stress is an imbalance of free radicals and antioxidants in the body, which can lead to cell and tissue damage. Oxidative stress can be responsible for the induction of several diseases, both chronic and degenerative, as well as speeding up body aging process and cause acute pathologies. Antioxidants are a class of compounds able to counteract oxidative stress and mitigate its effects on individuals’ health, gained enormous attention from the biomedical research community. Antioxidants have long been substantial and amenable therapeutic arsenals for multifarious diseases such as AD and cancer.

MCE Antioxidant Compound Library contains 1,857 compounds that act as antioxidants for high throughput screening (HTS) and high content screening (HCS). This library is a useful tool for discovery new antioxidants and oxidative stress research.

HY-L015

PI3K/Akt/mTOR Compound Library

823 compounds

The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.

MCE owns a unique collection of 823 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

Cat. No.	Product Name	Type

HY-P0136AF

FAM-SAMS TFA	Dyes
FAM-SAMS TFA is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

HY-13418G

Dorsomorphin dihydrochloride (GMP)

Compound C dihydrochloride (GMP); BML-275 dihydrochloride (GMP)

Fluorescent Dye

Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs) .

Cat. No.	Product Name	Type

HY-A0144A

Etilefrine hydrochloride

Biochemical Assay Reagents

Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-W011012

Adenosine 5'-monophosphate disodium

10+ Cited Publications

Enzyme Substrates

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-13418G

Dorsomorphin dihydrochloride (GMP)

Compound C dihydrochloride (GMP); BML-275 dihydrochloride (GMP)

Biochemical Assay Reagents

HY-137782

Palmitoleoyl-CoA	Biochemical Assay Reagents
Palmitoleoyl-CoA can be activated and transported into the mitochondria for metabolism, specifically for β-oxidation. Palmitoleoyl-CoA induces the cardiac mitochondrial membrane permeability transition, which causes mitochondrial dysfunction. Palmitoleoyl-CoA regulates metabolism via allosteric control of AMPK β1-isoforms .

HY-Y0319G

Magnesium acetate tetrahydrate

2 Publications Verification

Buffer Reagents

Magnesium acetate tetrahydrate is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Magnesium acetate tetrahydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Magnesium acetate tetrahydrate regulates energy metabolism. Magnesium acetate tetrahydrate has anticancer activity against gastric cancer. Magnesium acetate tetrahydrate induces writhing reaction and ulcerative colitis. Magnesium acetate tetrahydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .

HY-A0144AR

Etilefrine hydrochloride (Standard)

Biochemical Assay Reagents

Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-W011012R

Adenosine 5'-monophosphate disodium (Standard)

Enzyme Substrates

Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

Cat. No.	Product Name	Target	Research Area

HY-P0136AF

FAM-SAMS TFA	Fluorescent Dye	Others
FAM-SAMS TFA is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

HY-P0136

SAMS 2 Publications Verification	AMPK	Metabolic Disease
SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).

HY-P1576A

AMARA peptide TFA	Salt-inducible Kinase (SIK) AMPK	Others
AMARA peptide (TFA) is a substrate for salt-inducible kinase (SIK) and adenosine monophosphate activated protein kinase (AMPK).

HY-P1797A

Sakamototide substrate peptide TFA	Peptides	Others
Sakamototide substrate peptide TFA is a peptide substrate for members of the AMPK family of kinases, used in kinase activity assays .

HY-P2048

MOTS-c (human)	Apoptosis GLUT AMPK	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
MOTS-c (human) is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the *AMPK/PGC-1α* pathway to enhance insulin sensitivity. MOTS-c (human) inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate *AMPK, and then regulates the Nrf2/Keap1* antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .

HY-P2048A

MOTS-c(human) acetate	AMPK GLUT	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
MOTS-c (human) acetate is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the *AMPK/PGC-1α* pathway to enhance insulin sensitivity. MOTS-c (human) acetate inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate *AMPK, and then regulates the Nrf2/Keap1* antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) acetate has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .

HY-P0136F

FAM-SAMS	AMPK	Others
FAM-SAMS is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

HY-P10367

Ziptide	MAPKAPK2 (MK2) Checkpoint Kinase (Chk) AMPK	Others
Ziptide is a substrate for MAPK activated protein kinase 2 (MAPKAPK2, K_m = 5 μM), MAPKAPK3 (K_m = 30 μM), PARK (K_m = 40 μM), checkpoint kinase 1 (Chk1, K_m = 5 μM), AMP-activated protein kinase (AMPK, K_m = 75 μM), and calcium/calmodulin-dependent protein kinase II (CamKII, K_m = 300 μM) .

HY-P1576

AMARA peptide	Salt-inducible Kinase (SIK) AMPK	Inflammation/Immunology
AMARA peptide is a substrate for SIK and AMPK.

HY-163315

YPLP	Keap1-Nrf2 AMPK	Metabolic Disease
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active .

HY-P5435

LKBtide	Ser/Thr Kinase	Others
LKBtide is a biological active peptide. (This is a peptide substrate that is phosphorylated by Serine/Threonine kinase 11 (STK11), also known as LKB1. LKBtide is derived from sucrose non-fermenting 1 (SNF1) protein kinase, which is normally activated by the LKB1/AMP-activated protein kinase (AMPK) signaling pathway.)

HY-P10769

MOTS-c (mouse)	AMPK Apoptosis	Metabolic Disease
MOTS-c (mouse) is a mitochondrial-derived polypeptide that can be used to regulates pancreatic cell function. MOTS-c (mouse) reduces insulin secretion and expression in INS-1E cells, and enhances glucagon secretion and expression in αTC-1 cells. MOTS-c (mouse) decreases the apoptosis in INS-1E and αTC-1. MOTS-c (mouse) counteracts diet-induced obesity and insulin resistance through *AMPK* activation .

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, Bax, and reduces NF-κB, VCAM-1, MCP-1, and survivin. Propionyl-L-carnitine activates Src kinase, Akt, induces *p-AMPK* and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9349

Malvidin-3-O-arabinoside chloride 1 Publications Verification	Structural Classification Anthocyans Flavonoids Classification of Application Fields Vaccinium myrtillus Linn. Source classification Phenols Polyphenols Ericaceae Plants Inflammation/Immunology Disease Research Fields	AMPK Autophagy
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy .

HY-N4253

Kudinoside D 1 Publications Verification	Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Others
Kudinoside D is a main natural component of triterpenoid saponin derived from Ilex kudingcha. Kudinoside D suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes .

HY-W017212

Methyl cinnamate 2 Publications Verification Methyl 3-phenylpropenoate	Structural Classification Microorganisms Classification of Application Fields Simple Phenylpropanols Source classification Rutaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zanthoxylum armatum DC.	Tyrosinase Bacterial AMPK
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the *CaMKK2-AMPK* signaling pathway .

HY-N7676

Marein 2 Publications Verification	Cardiovascular Disease Structural Classification Chalcones Flavonoids other families Neurological Disease Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	AMPK HDAC
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .

HY-N6913

3α-Hydroxymogrol	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	AMPK
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent *AMPK* activator, and enhances AMPK phosphorylation .

HY-N7515

Pinocembrin chalcone 2',4',6'-Trihydroxychalcone	Structural Classification Chalcones Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Bacterial AMPK
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes .

HY-13417

AICAR 165+ Cited Publications Acadesine; AICA Riboside	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	AMPK Autophagy YAP Mitophagy Endogenous Metabolite
AICAR (Acadesine) is an adenosine analog and a *AMPK* activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity .

HY-N3425

Kazinol U	Flavonoids other families Classification of Application Fields Flavanols Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	AMPK
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

HY-N11924

Foenumoside B	Triterpenes Structural Classification Terpenoids Source classification Lysimachia foenum-graecum Hance Plants Primulaceae	AMPK PPAR
Foenumoside B is a triterpene saponin isolated from Lysimachia foenum-graecum. Foenumoside B activates *AMPK* signaling, inhibits PPARγ-induced adipogenesis, and shifts lipid metabolism toward lipolysis. Foenumoside B can be used in the study of obesity and obesity-related metabolic diseases .

HY-N6077

Thalidezine	Structural Classification Alkaloids Source classification Nelumbo nucifera Gaertn. Plants Nymphaeaceae Alkaloid Dimers	AMPK Apoptosis
Thalidezine is a novel activator of AMP-activated protein kinase (AMPK). Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention .

HY-N6971

Cimiracemoside C Cimicifugoside M	Triterpenes Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Source classification Metabolic Disease Cimicifuga foetida Linn. Plants Disease Research Fields	AMPK
Cimiracemoside C is an active component of Cimicifuga racemosa, activates *AMPK*, has the potential activity against diabetes .

HY-N0261

Aurantio-obtusin 1 Publications Verification	Seeds of Cassia tora Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Plants Quinones other families Leguminosae Anthraquinones Phenols Polyphenols Inflammation/Immunology Disease Research Fields	TNF Receptor COX
Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy- and AMPK/TFEB mediated inhibition of lipid accumulation .

HY-N2312

Mogrol 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Cancer	ERK STAT
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating *AMPK* signaling.

HY-B0923

Danthron 2 Publications Verification Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone	Quinones Structural Classification Classification of Application Fields Anthraquinones Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	AMPK Autophagy Bacterial Virus Protease
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating *AMPK*.

HY-N0261R

Aurantio-obtusin (Standard)	Seeds of Cassia tora Linn. Quinones Structural Classification other families Leguminosae Anthraquinones Source classification Phenols Polyphenols Plants	Reference Standards TNF Receptor COX
Aurantio-obtusin (Standard) is the analytical standard of Aurantio-obtusin. This product is intended for research and analytical applications. Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy-and AMPK/TFEB mediated inhibition of lipid accumulation .

HY-N4176

Ginkgolide K	Ginkgoaceae Terpenoids Source classification Diterpenoids Plants Ginkgo biloba	Autophagy
Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity .

HY-13417A

AICAR phosphate 165+ Cited Publications Acadesine phosphate; AICA Riboside phosphate	Alkaloids Structural Classification Animals Classification of Application Fields Other Alkaloids Source classification Disease Research Fields Cancer	AMPK Autophagy YAP Mitophagy Endogenous Metabolite
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a *AMPK* activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .

HY-N0671

Rhapontin 2 Publications Verification Rhaponiticin	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and *AMPK* activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .

HY-N1411

Platycodin D 5+ Cited Publications	Triterpenes Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Source classification Campanulaceae Metabolic Disease Plants Endogenous metabolite Disease Research Fields	AMPK Wnt
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-N10093

Chamaejasmine Chamaejasmin	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Apoptosis AMPK Autophagy Reactive Oxygen Species (ROS)
Chamaejasmine is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L. Chamaejasmine has antitumor activity. Chamaejasmine induces cell apoptosis, autophagy and ROS production, and activates the activity of *AMPK/mTOR* signal pathway .

HY-N6971R

Cimiracemoside C (Standard) Cimicifugoside M (Standard)	Triterpenes Structural Classification Terpenoids Ranunculaceae Source classification Cimicifuga foetida Linn. Plants	Reference Standards AMPK
Cimiracemoside C (Standard) is the analytical standard of Cimiracemoside C. This product is intended for research and analytical applications. Cimiracemoside C is an active component of Cimicifuga racemosa, activates AMPK, has the potential activity against diabetes .

HY-112108

Chitosan oligosaccharide 4 Publications Verification COS	Structural Classification Polysaccharides Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Cancer	AMPK Endogenous Metabolite
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates *AMPK* and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.

HY-B0923R

Danthron (Standard) Dantron (Standard); Chrysazin (Standard); 1,8-Dihydroxyanthraquinone (Standard)	Quinones Structural Classification Anthraquinones Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Plants	Reference Standards AMPK Autophagy Bacterial Virus Protease
Danthron (Standard) is the analytical standard of Danthron. This product is intended for research and analytical applications. Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

HY-N6258

Kahweol 1 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Source classification Rubiaceae Metabolic Disease Diterpenoids Plants Disease Research Fields Coffea arabica L.	AMPK Apoptosis
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

HY-N2312R

Mogrol (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants	Reference Standards ERK STAT
Mogrol (Standard) is the analytical standard of Mogrol. This product is intended for research and analytical applications. Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

HY-113352R

7-Methylguanine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Etilefrine (hydrochloride) (Standard) is the analytical standard of Etilefrine (hydrochloride). This product is intended for research and analytical applications. Etilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension .

HY-N5018

Nepodin Musizin	Rumex crispus Linn. Infection Structural Classification Classification of Application Fields Polygonaceae Source classification Phenols Polyphenols Rumex japonicus Houtt. Plants Disease Research Fields	Parasite AMPK
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N0671R

Rhapontin (Standard) 2 Publications Verification Rhaponiticin (Standard)	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Plants Disease Research Fields Cancer	Reference Standards Apoptosis
Rhapontin (Standard) is the analytical standard of Rhapontin (HY-N0671). This product is intended for research and analytical applications. Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and *AMPK* activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .

HY-N0072

Brazilin 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Apoptosis Autophagy
Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities .

HY-13417R

AICAR (Standard) Acadesine (Standard); AICA Riboside (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Source classification Endogenous metabolite	Reference Standards AMPK Autophagy YAP Mitophagy Endogenous Metabolite
AICAR (Standard) is the analytical standard of AICAR. This product is intended for research and analytical applications. AICAR (Acadesine) is an adenosine analog and a *AMPK* activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .

HY-13417AR

AICAR phosphate (Standard)	Alkaloids Structural Classification Animals Other Alkaloids Source classification	AMPK Autophagy YAP Mitophagy Endogenous Metabolite
AICAR (phosphate) (Standard) is the analytical standard of AICAR (phosphate). This product is intended for research and analytical applications. AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .

HY-N7459

Sakurasosaponin	Structural Classification Polysaccharides Tapeinosperma clethroides Mez Source classification Plants Primulaceae Saccharides	AMPK Autophagy Fungal
Sakurasosaponin is a saponin with potential anticancer activity that can be extracted from the root of Primula sieboldii. Sakurasosaponin can activate the AMPK pathway to induce cell autophagy and exert anti-NSCLC cell proliferation activity. Sakurasosaponin also has antifungal activity and significantly inhibits the growth of anthrax.

HY-N0735

Phellodendrine chloride 1 Publications Verification	Alkaloids Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Phenols Polyphenols Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Autophagy
Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis . Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis .

HY-W012980

Isovaleric acid	Structural Classification Classification of Application Fields Source classification Endocrine diseases Metabolic Disease Endogenous metabolite Biological Pesticide Research Agricultural Research Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Disease Research Fields	Endogenous Metabolite AMPK PKA
Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating *AMPK* phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders .

HY-N3426

Kazinol B	Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	NO Synthase Akt AMPK
Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research .

HY-N0592A

Demethyleneberberine chloride 1 Publications Verification	Structural Classification Alkaloids Phellodendron amurense Rupr. Source classification Rutaceae Phenols Polyphenols Plants	NF-κB AMPK
Demethyleneberberine chloride is a natural mitochondria-targeted antioxidant. Demethyleneberberine chloride alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine chloride could serve as a *AMPK* activator for researching non-alcoholic fatty liver disease (NAFLD) .

HY-N6904

Crocetin monomethyl ester	Structural Classification Neurological Disease Classification of Application Fields Terpenoids Source classification Diterpenoids Lridaceae Plants Crocus sativus L. Inflammation/Immunology Disease Research Fields	Amyloid-β
Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity . Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated *AMPK* pathway .

HY-N0592

Demethyleneberberine	Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	NF-κB AMPK
Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a *AMPK* activator for treating non-alcoholic fatty liver disease (NAFLD) .

HY-N1419

Vaccarin 1 Publications Verification	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	AMPK Akt ERK p38 MAPK NF-κB Nuclear Factor of activated T Cells (NFAT) JNK
Vaccarin is an orally active flavonoid glycoside with multiple biological functions. Vaccarin promotes neovascularization by activating AKT and ERK. Vaccarin activates the *AMPK* signaling pathway to improve insulin resistance and steatosis. Vaccarin is a MAPK, NF-κB, and NFAT inhibitor, effectively blocking RANKL-induced osteoclastogenesis .

HY-N0059

D-Arabinose	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Parasite Bacterial AMPK PPAR
D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0385

Gomisin J 3 Publications Verification	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields	NO Synthase AMPK CaMK NF-κB Keap1-Nrf2
Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, *AMPK* (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the *AMPK* pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .

HY-N1411R

Platycodin D (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Source classification Campanulaceae Plants Endogenous metabolite	Reference Standards AMPK Wnt
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-111431R

p-Cresyl sulfate (Standard) p-Tolyl sulfate (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards JNK p38 MAPK Reactive Oxygen Species (ROS)
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-N6258R

Kahweol (Standard)	Structural Classification other families Terpenoids Source classification Rubiaceae Diterpenoids Plants Coffea arabica L.	Reference Standards AMPK Apoptosis
Kahweol (Standard) is the analytical standard of Kahweol. This product is intended for research and analytical applications. Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

HY-N1419R

Vaccarin (Standard)	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Reference Standards AMPK
Vaccarin (Standard) is the analytical standard of Vaccarin. This product is intended for research and analytical applications. Vaccarin is an active flavonoid glycoside associated with various biological functions. Vaccarin significantly promote wound healing and endothelial cells and fibroblasts proliferation in the wound site. Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway .

HY-137782

Palmitoleoyl-CoA	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Biochemical Assay Reagents
Palmitoleoyl-CoA can be activated and transported into the mitochondria for metabolism, specifically for β-oxidation. Palmitoleoyl-CoA induces the cardiac mitochondrial membrane permeability transition, which causes mitochondrial dysfunction. Palmitoleoyl-CoA regulates metabolism via allosteric control of AMPK β1-isoforms .

HY-N5018R

Nepodin (Standard) Musizin (Standard)	Rumex crispus Linn. Structural Classification Polygonaceae Source classification Phenols Polyphenols Rumex japonicus Houtt. Plants	Reference Standards Parasite AMPK
Nepodin (Standard) is the analytical standard of Nepodin. This product is intended for research and analytical applications. Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N7697R

Chitotetraose tetrahydrochloride (Standard)	Structural Classification Polysaccharides Microorganisms Source classification Saccharides	Reference Standards Others
Butylate (Standard) is the analytical standard of Butylate. This product is intended for research and analytical applications. Butylate is a compound involved in platelet research. Platelet activation can cause autophagy, which is partly mediated by the AMPK-MTOR pathway and is related to sphingolipid metabolism. Butylate mentioned in the study may be a tool or control substance for studying related metabolic processes.

HY-N7082

D-Arabinopyranose	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Disease Research Fields Saccharides Monosaccharides	Parasite Bacterial AMPK PPAR
D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0806

Sweroside 1 Publications Verification	Filago spathulata Presl. Structural Classification Monophenols Classification of Application Fields Labiatae Phenols Metabolic Disease Plants Disease Research Fields	Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP
Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, *AMPK/mTOR* pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .

Recombinant Proteins Recommended:

AMPK

Species:	Human (8)
Tag:	His (6) GST (6)
Source:	Sf9 insect cells (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P76141

	AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) 1 Publications Verification 5'-AMP-activated protein kinase; AMPK; AMPK (α1, β1, γ1) Protein	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 1/alpha 1 Heterotrimer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of 38 (beta-1)&40 (gamma-1)&95 (alpha-1) kDa, respectively.

HY-P76142

	AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) 5'-AMP-activated protein kinase; AMPK; AMPK (α2, β1, γ1) Protein	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 1/alpha 2 Heterotrimer protein, expressed by Sf9 insect cells , with N-His, N-GST, N-10*His labeled tag. AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of ~40 & 42 & 95 KDa, respectively.

HY-P76143

	AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) 5'-AMP-activated protein kinase; AMPK; AMPK (α1, β2, γ1) Protein	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 2/alpha 1 Heterotrimer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of ~35 & 37 & 95 KDa, respectively.

HY-P76144

	AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) 5'-AMP-activated protein kinase; AMPK; AMPK (α2, β2, γ1) Protein	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 2/alpha 2 Heterotrimer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of ~35 & 37 & 95 KDa, respectively.

HY-P702896

	AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His) AMPK1	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 1/alpha 1 Protein, Human (sf9, His) is the recombinant human-derived AMPK gamma 1/beta 1/alpha 1, expressed by Sf9 insect cells, with C-6*His labeled tag.

HY-P702978

	AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (Inactive, sf9, His) Subunits A2: PRKAA2; AMPK; AMPK2; PRKAA Subunit B1: PRKAB1; AMPK; HAMPKb; MGC17785 Subunit G1: PRKAG1; AMPKG; MGC866	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK (gamma 1/beta 1/alpha 2) Protein, Human (Inactive, sf9, His) is the recombinant human-derived AMPK (gamma 1/beta 1/alpha 2), expressed by Sf9 insect cells , with His labeled tag. ,

HY-P702979

	AMPKG1 Protein, Human (sf9, GST) 5'-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK subunit gamma-1; AMPKg; PRKAG1	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPKG1 Protein, Human (sf9, GST) is the recombinant human-derived AMPKG1, expressed by Sf9 insect cells , with GST labeled tag.

HY-P702656

	NUAK1 Protein, Human (sf9, GST) NUAK1; NUAK family, SNF1-like kinase, 1; NUAK family SNF1-like kinase 1; AMP activated protein kinase family member 5; ARK5; KIAA0537; NuaK1; omphalocele kinase 1; AMPK-related protein kinase 5; AMP-activated protein kinase family member 5	Human	Sf9 insect cells
	NUAK1 Protein, Human (sf9, GST) is the recombinant human-derived NUAK1, expressed by Sf9 insect cells , with GST labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-12357S2

Bempedoic acid-d4
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK .

HY-110228

Metformin-d6 hydrochloride

Metformin-d₆ hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

HY-16397AS

Phenformin-d5 hydrochloride
Phenformin-d₅ (hydrochloride) is the deuterium labeled Phenformin hydrochloride. Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity .

HY-W017212S

Methyl cinnamate-d7

Methyl cinnamate-d₇ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-12357S

Bempedoic acid-d5
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid . Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .

HY-B0627S

Metformin-d6

Metformin-d₆ (1,1-Dimethylbiguanide-d₆) is a deuterated labeled Metformin (HY-B0627). Metformin inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

HY-B0627S1

Metformin-13C2 hydrochloride

Metformin- ¹³C₂ (1,1-Dimethylbiguanide- ¹³C₂) hydrochloride is the ¹³C-labeled Metformin hydrochloride (HY-17471A). Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

HY-N0059S5

D-Arabinose-d5

D-Arabinose-d₅ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S4

D-Arabinose-d2

D-Arabinose-d₂ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S

D-Arabinose-13C

D-Arabinose- ¹³C is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S6

D-Arabinose-d6

D-Arabinose-d₆ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-B2099S

Buformin-d9 hydrochloride
Buformin-d₉ (hydrochloride) is the deuterium labeled Buformin. Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) .

HY-N0059S2

D-arabinose-13C-2

D-Arabinose- ¹³C-2 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S1

D-Arabinose-13C-1

D-Arabinose- ¹³C-1 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S3

D-Arabinose-13C-3

D-Arabinose- ¹³C-3 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N7082S

D-Arabinopyranose-13C5

D-Arabinopyranos- ¹³C₅ is ¹³C labeled D-Arabinopyranos (HY-N7082). D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-13417S

AICAR-13C2,15N
AICAR- ¹³C₂, ¹⁵N (Acadesine- ¹³C₂, ¹⁵N; AICA Riboside- ¹³C₂, ¹⁵N) is the ¹³C and ¹⁵N labeled AICAR (HY-13417) . AICAR (Acadesine) is an adenosine analog and a *AMPK* activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .

HY-B1221S1

Flufenamic acid-13C6

Flufenamic acid- ¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-B1221S

Flufenamic acid-d4

Flufenamic acid-d₄ is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-W011012S

Adenosine 5'-monophosphate-13C disodium

Adenosine 5'-monophosphate- ¹³C (disodium) is a ¹³C-labeled Adenosine 5'-monophosphate (HY-W011012). Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-W011012S1

Adenosine 5'-monophosphate-d2 disodium

Adenosine 5'-monophosphate-d₂ disodium is the deuterium labeled Adenosine 5'-monophosphate (HY-W011012). Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-N8016S2

Nonanal-d2
Nonanal-d₂ is deuterated labeled Nonanal (HY-N8016). Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity .

HY-B1885S

Fenitrothion-d6

Fenitrothion-d₆ is the deuterium labeled Fenitrothion (HY-B1885). Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .

HY-W701218

Sulforaphane-d8

Sulforaphane-d₈ is the deuterium labeled Sulforaphane (HY-13755). Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80542

	AMPK beta 1 Antibody 5' ' -AMP-activated protein kinase subunit beta-1; AMP-activated; noncatalytic; beta-1; AMPK; AMPK beta 1 chain; AMPK subunit beta-1; AMPK-BETA-1; AMPKb; HAMPKb; PRKAB1	WB, IHC-P, FC, IP	Human, Mouse, Rat
	AMPK beta 1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 30 kDa, targeting to AMPK beta 1. It can be used for WB,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80541

	AMPK alpha Antibody (YA622) 1 Publications Verification PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB, IP	Human
	AMPK alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 62 kDa, targeting to AMPK alpha. It can be used for WB,IP assays with tag free, in the background of Human .

HY-P80540

	AMPK alpha 2 Antibody (YA623) PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB, IP	Human, Rat
	AMPK alpha 2 Antibody (YA623) is a non-conjugated and Rabbit origined monoclonal antibody about 62 kDa, targeting to AMPK alpha 2. It can be used for WB,IP assays with tag free, in the background of Human, Rat.

HY-P80376

	AMPK alpha 1 Antibody (YA624)	WB, ICC/IF, FC, IP	Human, Rat
	AMPK alpha 1 Antibody (YA624) is a non-conjugated and Rabbit origined monoclonal antibody about 64 kDa, targeting to AMPK alpha 1. It can be used for WB,ICC/IF,FC,IP assays with tag free, in the background of Human, Rat.

HY-P80377

	AMPK alpha 2 Antibody (YA833)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	AMPK alpha 2 Antibody (YA833) is a non-conjugated and Mouse origined monoclonal antibody about 62 kDa, targeting to AMPK alpha 2. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80543

	AMPK gamma 1 Antibody (YA621) AMPKG	WB, ICC/IF, IP	Human
	AMPK gamma 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 38 kDa, targeting to AMPK gamma 1. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human.

HY-P80539

	AMPK alpha 1 Antibody PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	AMPK alpha 1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 64 kDa, targeting to AMPK alpha 1. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P85706

	AMPKγ1 Antibody (YA5398) 5'-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK subunit gamma-1; AMPKg;	IHC-P, WB	Human, Mouse, Rat
	AMPKγ1 Antibody (YA5398) is a mouse-derived and non-conjugated monoclonal antibody, targeting to AMPKγ1. It can be applicated for IHC-P, WB assays, in the background of human, mouse, rat.

HY-P85034

	AMPKα1 Antibody (YA4726) PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
	AMPKα1 Antibody (YA4726) is a mouse-derived and non-conjugated monoclonal antibody, targeting to AMPKα1. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rat, monkey.

HY-P85578

	AMPKβ1 Antibody (YA5270) 1300015D22Rik; 5 AMP activated protein kinase subunit beta 1; 5''-AMP-activated protein kinase subunit beta-1; AAKB1_HUMAN; AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1; AMP-activated, noncatalytic, beta-1; AMPK; AMPK beta 1 chain; AMPK subunit beta-1; AMPK-BETA-1; AMPKb; AU021155; E430008F22; HAMPKb; MGC17785; PRKAB1.	WB, ICC/IF, IP, IHC-P	Human, Mouse, Rat, Monkey
	AMPKβ1 Antibody (YA5270) is a mouse-derived and non-conjugated monoclonal antibody, targeting to AMPKβ1. It can be applicated for WB, ICC/IF, IP, IHC-P assays, in the background of human, mouse, rat, monkey.

HY-P85745

	AMPKα1 Antibody (YA5437) PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF	Human
	AMPKα1 Antibody (YA5437) is a mouse-derived and non-conjugated monoclonal antibody, targeting to AMPKα1. It can be applicated for WB, IHC-P, ICC/IF assays, in the background of human.

HY-P85709

	AMPKβ2 Antibody (YA5401) 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2;	IHC-P, WB	Human, Mouse, Rat
	AMPKβ2 Antibody (YA5401) is a mouse-derived and non-conjugated monoclonal antibody, targeting to AMPKβ2. It can be applicated for IHC-P, WB assays, in the background of human, mouse, rat.

HY-P85708

	AMPKβ1 Antibody (YA5400) 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb;	IHC-P, WB	Human, Mouse, Rat
	AMPKβ1 Antibody (YA5400) is a mouse-derived and non-conjugated monoclonal antibody, targeting to AMPKβ1. It can be applicated for IHC-P, WB assays, in the background of human, mouse, rat.

HY-P84394

	PRKAA2 Antibody (YA4091) AMPK; AMPK2; PRKAA; AMPKa2	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
	PRKAA2 Antibody (YA4091) is a mouse-derived and non-conjugated IgG1 antibody, targeting to PRKAA2. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rat, monkey, rabbit.

HY-P80791

	*Phospho-AMPK* alpha 2 (Thr172) Antibody** PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB	Human, Mouse, Rat
	Phospho-AMPK alpha 2 (Thr172) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 62 kDa, targeting to Phospho-AMPK alpha 2 (Thr172). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P80452

	*Phospho-AMPK* alpha 2(Ser345) Antibody (YA225)** 1 Publications Verification	WB, ICC/IF, IHC-P	Human, Mouse
	Phospho-AMPK alpha 2(Ser345) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 62 kDa, targeting to Phospho-AMPK alpha 2(S345). It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P80451

	*Phospho-AMPK* alpha 1 (Ser496) Antibody (YA226)**	WB, ICC/IF, IP	Human
	Phospho-AMPK alpha 1 (Ser496) Antibody (YA226) is a non-conjugated and Rabbit origined monoclonal antibody about 64 kDa, targeting to Phospho-AMPK alpha 1 (S496). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human.

HY-P80790

	*Phospho-AMPK* alpha 1 (Ser496) Antibody** PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF	Human
	Phospho-AMPK alpha 1 (Ser496) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 64 kDa, targeting to Phospho-AMPK alpha 1 (Ser496). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P84528

	PRKAA1 Antibody (YA4225) AMPK; AMPKa1; MGC33776; MGC57364; PRKAA1	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Rat, Monkey
	PRKAA1 Antibody (YA4225) is a mouse-derived and non-conjugated IgG1 antibody, targeting to PRKAA1. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA, ELISA assays, in the background of human, mouse, rat, monkey.

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Cat. No.	Product Name		Classification

HY-W011527

Xanthosine 2 Publications Verification		Nucleosides and their Analogs
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research .

HY-N0131

Stigmasterol 5+ Cited Publications		Cholesterol
Stigmasterol is an orally acitve, immunomodulatory agent with anti-inflammatory and neuroprotective effect, as well as able to cross the blood-brain barrier. Stigmasterol activates *AMPK, which in turn inhibits NF-κB* and NLRP3 signaling pathways, reduces microglia-mediated neuroinflammation, and alleviates cognitive impairment and Alzheimer's disease. Stigmasterol regulates M1/M2 polarization of microglia through the TLR4/ NF-κB pathway, thereby reducing neuropathic pain. Stigmasterol can be used for neurodegenerative diseases, inflammatory diseases, and pain management, among others .

HY-RS11102

PRKAB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRKAB1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKAB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS27694

Prkaa2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Prkaa2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkaa2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11100

PRKAA1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRKAA1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKAA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11101

PRKAA2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRKAA2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKAA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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