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Results for "

class I

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Scavenger Receptor Class B type I (SR-BI） (1) ADC Payload (2) Akt (2) Antibiotic (1) Apoptosis (37) Arenavirus (2) Autophagy (15) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (1) CD3 (1) CDK (1) Cytochrome P450 (2) Disulfidptosis (1) DNA-PK (1) DNA/RNA Synthesis (2) Endogenous Metabolite (4) Epigenetic Reader Domain (2) ERK (1) Fc Receptor (FcR) (1) Filovirus (3) G protein-coupled Bile Acid Receptor 1 (2) GLUT (2) Glycosidase (1) HBV (1) HDAC (52) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (1) Histone Methyltransferase (1) HIV (3) HPV (3) HSP (1) Influenza Virus (3) Interleukin Related (2) Isotope-Labeled Compounds (4) JAK (2) LXR (1) MEK (1) MHC (34) Mitochondrial Metabolism (1) Mitophagy (5) MMP (1) Monoamine Transporter (1) mRNA (2) mTOR (11) MyD88 (1) nAChR (1) NF-κB (3) Organoid (1) P-glycoprotein (2) p38 MAPK (1) Paraptosis (1) Phosphodiesterase (PDE) (1) PI3K (35) PKD (1) Potassium Channel (4) PROTACs (8) Raf (1) Ras (1) Reference Standards (4) RSV (1) Ser/Thr Kinase (1) Sirtuin (2) Sodium Channel (3) Toll-like Receptor (TLR) (2) Topoisomerase (2) Transmembrane Glycoprotein (2) Tyrosinase (1) VEGFR (1)
By Research Areas:	Cancer (102) Cardiovascular Disease (18) Infection (15) Inflammation/Immunology (37) Metabolic Disease (4) Neurological Disease (6)
Click Chemistry:	Azide (1)
Oligonucleotides:	mRNA (2)

172

Inhibitors & Agonists

Fluorescent Dye

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Inhibitory Antibodies

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Isotope-Labeled Compounds

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Targets Recommended: Scavenger Receptor Class B type I (SR-BI） CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99135

*Anti-Mouse MHC Class* I (H-2Kb) Antibody (Y-3)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) is a mouse-derived IgG2b antibody inhibitor, targeting to mouse *MHC Class* I (H-2Kb)*. Anti-Mouse MHC Class* I (H-2Kb) Antibody (Y-3) reacts with the mouse H-2Kb, H-2Kk, H-2Kq, H-2Kr, H-2ks MHC class I alloantigens and not H-2Kd. Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) can block MHC Class I. Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) can be used for immunology research .

HY-P990195

*Anti-Mouse MHC Class* I (H-2) Antibody (M1/42.3.9.8)**	MHC	Others
Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse *MHC Class* I*. Anti-Mouse MHC Class* I (H-2) Antibody (M1/42.3.9.8) reacts with the mouse H-2 MHC class I alloantigen (all haplotypes). Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) can be used for the flow cytometry and immunofluorescence experiments .

HY-P990832

*Anti-MHC Class* I Antibody (W6/32)**	MHC	Inflammation/Immunology
Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human *MHC Class* I*. Anti-MHC Class* I Antibody (W6/32) reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. Anti-MHC Class I Antibody (W6/32) increases adherence of monocytes to human endothelial cells. Anti-MHC Class I Antibody (W6/32) can be used for the research of immunology .

HY-P990187

*Anti-Mouse MHC Class* II (I-A/I-E) Antibody (M5/114)**	MHC Influenza Virus	Infection Inflammation/Immunology
Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse *MHC Class* II*. Anti-Mouse MHC Class* II (I-A/I-E) Antibody (M5/114) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) does not react with I-Af, I-Ak, or I-As haplotypes. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) blocks MHC Class II and inhibit T cell generation. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) can be used for the researches of infection and immunology, such as influenza A virus (IAV) infection .

HY-P990194

*Anti-Mouse MHC Class* I (H-2Kd) Antibody (HB-159)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse *MHC Class* I*. Anti-Mouse MHC Class* I (H-2Kd) Antibody (HB-159) reacts with the mouse H-2Kd MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) can be used for immunology research, such as cardiac graft .

HY-P990190

*Anti-Swine MHC Class* I (SLAd) Antibody (74-11-10)**	MHC	Others
Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to *Swine MHC Class* I*. Anti-Swine MHC Class* I (SLAd) Antibody (74-11-10) reacts with the swine leucocyte antigen (SLA) class I. Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) can be used for the research of flow cytometry experiments .

HY-P990192

*Anti-Mouse MHC Class* I (H-2Kk) Antibody (AF3-12.1.3)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) is a mouse-derived IgG1 type antibody inhibitor, targeting to mouse *MHC Class* I*. Anti-Mouse MHC Class* I (H-2Kk) Antibody (AF3-12.1.3) reacts with the mouse H-2Kk MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) can be used for the researches of inflammation and immunology, such as obliterative airway disease .

HY-P990813

*Anti-Mouse Nonclassical MHC Class* I molecule Qa-1b Antibody (4C2.4A7.5H11)**	MHC	Cancer
Anti-Mouse Nonclassical MHC Class I molecule Qa-1b Antibody (4C2.4A7.5H11) is a mouse-derived IgG1 antibody inhibito, targeting to mouse *Nonclassical MHC Class* I molecule Qa-1b*. Anti-Mouse Nonclassical MHC Class* I molecule Qa-1b Antibody (4C2.4A7.5H11) reacts with the mouse non-classical MHC class I molecule Qa-1b. Anti-Mouse Nonclassical MHC Class I molecule Qa-1b Antibody (4C2.4A7.5H11) can be used for the research of cancer, such as B16F10 tumor .

HY-P990191

*Anti-Mouse MHC Class* I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13))**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse *MHC Class* I*. Anti-Mouse MHC Class* I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) reacts with the mouse H-2Kk and H-2Dk MHC class I alloantigens. Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) can be used for immunology research .

HY-P990186

*Anti-Mouse MHC Class* II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2)**	MHC	Others
Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) is a mouse-derived IgG2c κ type antibody inhibitor, targeting to mouse *MHC Class* II*. Anti-Mouse MHC Class* II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) reacts with mouse MHC Class II haplotypes I-Ak, I-Ar, I-Af, I-As, and I-Ag7. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) does not react with I-Ab, I-Ad, I-Ap, or I-Aq haplotypes. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) blocks MHC Class II and inhibits antigen proliferation responses. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) can be used for the research of immunology .

HY-P990188

*Anti-Mouse MHC class* II (I-A) Antibody (Y-3P)**	MHC	Inflammation/Immunology
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse *MHC class* II*. Anti-Mouse MHC class* II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .

HY-106700

Pentisomide CM 7857; Penticainide; Propisomide	Sodium Channel	Cardiovascular Disease
Pentisomide (CM 7857), a is an orally active antiarrhythmic agent that blocks sodium channels. Pentisomide processes Vaughan-Williams class I (class I) antiarrhythmic actions .

HY-P990185

*Anti-Mouse/Rat MHC Class* II (I-Ek/RT1-D) Antibody (14-4-4S)**	MHC	Inflammation/Immunology Cancer
Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/rat *MHC Class* II*. Anti-Mouse/Rat MHC Class* II (I-Ek/RT1-D) Antibody (14-4-4S) reacts with mouse MHC Class II alloantigen I-Ek and the rat MHC class II alloantigen RT1D. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) blocks antigen presentation. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) can be used for the research of immunology and cancer .

HY-P990193

*Anti-Mouse MHC Class* I (H-2Kd, H-2Dd) Antibody (34-1-2S)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) is an anti-mouse *MHC Class* I (H-2Kd, H-2Dd)** IgG2a monoclonal antibody. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can block the interaction between Ly49 and MHC-I. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can be used for the construction of acute lung injury models .

HY-161111

KVS0001	Ser/Thr Kinase	Cancer
KVS0001 is a selective SMG1 inhibitor. KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations. KVS0001 increased the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases .

HY-123849

SN32976	PI3K mTOR	Cancer
SN32976 is a potent and selective class I PI3K and mTOR inhibitor with IC₅₀s of 15.1 nM, 461 nM, 110 nM, 134 nM and 194 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR, respectively. SN32976 shows high selectivity among other 442 kinases. SN32976 shows anticancer effects .

HY-P990184

*Anti-Mouse MHC Class* II (βchain) Antibody (KL277)**	MHC	Others
Anti-Mouse MHC Class II (βchain) Antibody (KL277) is a hamster/mouse-derived IgG type antibody inhibitor, targeting to mouse *MHC Class* II*. Anti-Mouse MHC Class* II (βchain) Antibody (KL277) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Ap, I-Aq, I-Abu, and I-Abw. Anti-Mouse MHC Class II (βchain) Antibody (KL277) does not react with I-Aa, I-Ak, I-Af, I-Aj, I-As, or I-Atl haplotypes. Anti-Mouse MHC Class II (βchain) Antibody (KL277) can be used for western blot experiments .

HY-P3715

OVA peptide 2 Publications Verification	MHC	Inflammation/Immunology
OVA peptide mainly exists in egg white, it is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC). OVA peptide has been widely studied in allergy research .

HY-15466

Izorlisib 3 Publications Verification CH5132799	PI3K	Cancer
Izorlisib (CH5132799) is a selective class I PI3K inhibitor. Izorlisib inhibits class I PI3Ks, particularly PI3Kα, with an IC₅₀ of 14 nM.

HY-P5410

OVA-Q4 Peptide	MHC	Others
OVA-Q4 Peptide is a biological active peptide. (Q4 Peptide (SIIQFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).)

HY-U00232

Bidisomide SC40230	Others	Cardiovascular Disease
Bidisomide (SC40230) is a class I antiarrhythmic agent.

HY-P1489

OVA Peptide(257-264) 10+ Cited Publications	MHC	Inflammation/Immunology
OVA Peptide(257-264) is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.

HY-P1489A

OVA Peptide(257-264) TFA 10+ Cited Publications	MHC	Inflammation/Immunology
OVA Peptide(257-264) TFA is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.

HY-P1489B

OVA Peptide(257-264) acetate salt	MHC	Inflammation/Immunology
OVA Peptide(257-264) acetate salt is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb .

HY-P5411

OVA-T4 Peptide SIITFEKL, OVA (257-264) Variant	MHC	Others
OVA-T4 Peptide (SIITFEKL, OVA (257-264) Variant) is a biological active peptide. (T4 peptide (SIITFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).)

HY-18600B

(E)-Azimilide (E)-NE-10064	Potassium Channel	Cardiovascular Disease
(E)-Azimilide is an isomer of Azimilide (HY-18600), a class of antiarrhythmic compounds that inhibit I(Ks) and I(Kr) activity .

HY-168153

HDAC-IN-80	HDAC	Cancer
HDAC-IN-80 (compund 5) is a selective class I HDAC inhibitor .

HY-145350

HDAC-IN-26	HDAC	Infection
HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC₅₀ value of 4.7 nM.

HY-157281

Photolumazine III PLIII	Transmembrane Glycoprotein	Inflammation/Immunology
Photolumazine III is a MHC class I related-1 molecule (MR1) antigen .

HY-P991142

Isuventatug	MHC	Inflammation/Immunology Cancer
Isuventatug is a monoclonal antibody targeting human MICA (MHC class I chain-related molecule A) and MICB (MHC class I chain-related molecule B). Isuventatug binds to MICA and MICB to regulate the interaction between immune cells and tumor cells, exerting antitumor activity. Isuventatug is promising for research of cancer immunotherapy .

HY-12484

BMH-21 5+ Cited Publications	DNA/RNA Synthesis	Cancer
BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .

HY-13592

HDAC-IN-7 Chidamide impurity	HDAC	Cancer
HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor.

HY-129738

I942	Ras	Cardiovascular Disease
I942 is a first in class, selective non-cyclic nucleotide (NCN) EPAC1 agonist. I942 can attenuate proinflammatory cytokine signalling normally associated with cardiovascular diseases .

HY-15144

Trichostatin A Maximum Cited Publications 176 Publications Verification TSA	Organoid HDAC	Cancer
Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC₅₀ value of 1.8 nM for HDAC .

HY-19332

Kifunensine 10+ Cited Publications FR-900494	Glycosidase	Inflammation/Immunology
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .

HY-117554

BRD9757	HDAC	Cancer
BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC₅₀ of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs .

HY-W705106

(-)-Coclaurine hydrochloride 1 Publications Verification (-)-(S)-Coclaurine hydrochloride; L-Coclaurine hydrochloride	nAChR	Neurological Disease
(-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist .

HY-18310

NIBR-17	PI3K	Cancer
NIBR-17 is a pan-class I PI3K inhibitor with suitable pharmacokinetic properties and inhibits tumor growth .

HY-10221G

Vorinostat (GMP) SAHA (GMP); Suberoylanilide hydroxamic acid (GMP)	HDAC	Infection Cancer
Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available *HDAC1, HDAC2, HDAC3 (Class* I), HDAC6 and Inhibitors of HDAC7 (Class II)** and Class IV (HDAC11) .

HY-16259

Indecainide hydrochloride Ricainide hydrochloride; LY 135837	Sodium Channel	Cardiovascular Disease
Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent. Indecainide hydrochloride has Na ⁺-channel-blocking activity .

HY-P5746

Suicin 65	ADC Payload Antibiotic	Others
Suicin 65 is a class I type B lantibiotic produced by Streptococcus suis. Suicin 65 is active against all S. suis isolates .

HY-164400

SIJ1777	MEK ERK Akt Apoptosis	Cancer
SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations .

HY-109015S

Tucidinostat-d4 Chidamide-d₄; HBI-8000-d₄; CS 055-d₄	Isotope-Labeled Compounds HDAC	Cancer
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC₅₀s of 95, 160, 67 and 78 nM, respectively .

HY-P5453

CFP10 (71–85)	CD3	Others
CFP10 (71–85) is a biological active peptide. (CFP1071–85, that elicited IFN-γ production and CTL activity by both CD4+ and CD8+ T cells from persons expressing multiple MHC class II and class I molecules)

HY-12163

Entinostat 75+ Cited Publications MS-275; SNDX-275	HDAC Autophagy Apoptosis	Cancer
Entinostat is an oral and selective class I HDAC inhibitor, with IC₅₀s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively.

HY-N11084

Salviaplebeiaside	P-glycoprotein	Others
Salviaplebeiaside is a phenolic substance can be isolated from the aerial part of Vitex negundo var. cannabifolia. Salviaplebeiaside is an inhibitor of class I p-glycoprotein .

HY-P4044

HBV Seq2 aa:28-39	HBV	Infection
HBV Seq2 aa:28-39 is a HBsAg peptide, which binds to major histocompatibility complex (MHC) class I molecules .

HY-119939

CHDI-390576 1 Publications Verification	HDAC	Cancer
CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC₅₀s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform .

HY-P10296

p60 (217–225)	Endogenous Metabolite	Infection
p60 (217–225) is the subdominant epitope of Listeria monocytogenes, which combines with H-2K ^d MHC class I molecules .

HY-P2455

LLO (91-99) Listeriolysin O (91-99)	Bacterial	Infection Inflammation/Immunology
LLO (91-99) (Listeriolysin O (91-99)) is an exotoxin and class I MHC-restricted T-cell epitope of listeriolysin (LLO). LLO (91-99) is processed by antigen-presenting cells, binds to MHC class I molecules and is presented to the cell surface. LLO (91-99) induces CTL responses and effectively eliminates Listeria from infected cells. LLO (91-99) can be used in the research of Listeria infections (e.g., listeriosis) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15144

Trichostatin A Maximum Cited Publications 176 Publications Verification TSA	Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Organoid HDAC
Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC₅₀ value of 1.8 nM for HDAC .

HY-19332

Kifunensine 10+ Cited Publications FR-900494	Alkaloids Piperidine Alkaloids Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Glycosidase
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .

HY-W705106

(-)-Coclaurine hydrochloride 1 Publications Verification (-)-(S)-Coclaurine hydrochloride; L-Coclaurine hydrochloride	Alkaloids Piperidine Alkaloids Source classification Cocculus laurifolius DC. Plants Menispermaceae	nAChR
(-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist .

HY-N0141

Parthenolide 30+ Cited Publications (-)-Parthenolide	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Euchresta formosana (Hayata) Ohwi Disease Research Fields Cancer	NF-κB Autophagy Mitophagy Apoptosis
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

HY-147061

2-Deoxyribose 5-phosphate disodium	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
2-Deoxyribose 5-phosphate disodium is a substrate of 2-deoxyribose-5-phosphate aldolase (DERA). DERA belongs to the class I aldolases and catalyzes the reversible aldol condensation reaction without any cofactors .

HY-N0141R

Parthenolide (Standard) (-)-Parthenolide (Standard)	Terpenoids Sesquiterpenes Source classification Plants Compositae Euchresta formosana (Hayata) Ohwi	Reference Standards NF-κB Autophagy Mitophagy Apoptosis
Parthenolide (Standard) is the analytical standard of Parthenolide. This product is intended for research and analytical applications. Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

HY-W009783

1-Deoxymannojirimycin hydrochloride 1 Publications Verification	Infection Alkaloids Piperidine Alkaloids other families Classification of Application Fields Source classification Plants Disease Research Fields	HIV Influenza Virus
1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC₅₀ of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. 1-Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . 1-Deoxymannojirimycin hydrochloride increases high mannose structures. 1-Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer .

HY-N11084

Salviaplebeiaside	Verbenaceae Source classification Phenols Polyphenols Plants Vitex negundo Linn.	P-glycoprotein
Salviaplebeiaside is a phenolic substance can be isolated from the aerial part of Vitex negundo var. cannabifolia. Salviaplebeiaside is an inhibitor of class I p-glycoprotein .

Cat. No.	Product Name	Chemical Structure

HY-109015S

Tucidinostat-d4
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC₅₀s of 95, 160, 67 and 78 nM, respectively .

HY-12163S

Entinostat-d4
Entinostat-d₄ is the deuterium labeled Entinostat . Entinostat is an oral and selective class I HDAC inhibitor, with IC₅₀s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively .

HY-B0615AS

Moricizine-d8(Hydrochloride)
Moricizine-d₈ Hydrochloride is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .

HY-W710915

Aprindine hydrochloride-d10

Aprindine hydrochloride-d₁₀ is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

HY-126855S

Cholic acid 7-sulfate-d4

Cholic acid 7-sulfate-d₄ (7-Sulfocholic acid-d₄) is the deuterium labeled Cholic acid 7-sulfate (HY-126855). Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC₅₀=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation .

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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