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Results for "

Dermal papilla cells,apoptotic,Bcl-2/Bax

" in MedChemExpress (MCE) Product Catalog:

By Targets:	15-PGDH (1) Adrenergic Receptor (9) Akt (13) AMPK (1) Androgen Receptor (1) Antibiotic (8) AP-1 (1) Apoptosis (176) Aryl Hydrocarbon Receptor (1) ATF6 (1) Atg8/LC3 (1) Autophagy (28) Bacterial (11) Bcl-2 Family (128) Beta-lactamase (1) Biochemical Assay Reagents (8) Bombesin Receptor (1) c-Myc (1) Cadherin (1) Calcium Channel (1) Cannabinoid Receptor (1) Carbonic Anhydrase (2) Caspase (58) Cathepsin (1) CDK (4) CGRP Receptor (2) Checkpoint Kinase (Chk) (1) Chloride Channel (2) Cholinesterase (ChE) (1) COX (7) Cytochrome P450 (6) Dimethylargininase (DDAH) (1) DNA/RNA Synthesis (2) Dopamine β-hydroxylase (2) Drug Derivative (2) Drug Metabolite (1) EAAT (1) EGFR (12) Endogenous Metabolite (10) Epigenetic Reader Domain (1) ERK (3) Eukaryotic Initiation Factor (eIF) (1) Factor VIIa (2) Factor Xa (2) Fatty Acid Synthase (FASN) (4) Fc Receptor (FcR) (1) Ferroptosis (8) FGFR (1) Fungal (5) Glucocorticoid Receptor (1) Glycosidase (1) GSK-3 (1) HBV (1) HCV (4) HDAC (5) HIV (1) HSP (2) HSV (5) IAP (2) iGluR (1) Imidazoline Receptor (7) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (4) Insecticide (1) Interleukin Related (1) Isotope-Labeled Compounds (3) JNK (5) Keap1-Nrf2 (4) Ligands for E3 Ligase (1) LXR (1) Macrophage migration inhibitory factor (MIF) (1) MDM-2/p53 (15) MEK (2) Melanocortin Receptor (2) Microtubule/Tubulin (5) Mitophagy (7) Mixed Lineage Kinase (1) MMP (4) Monoamine Oxidase (1) Motilin Receptor (1) mRNA (1) mTOR (3) MyD88 (1) Na+/K+ ATPase (1) Necroptosis (1) NF-κB (14) NO Synthase (1) P-glycoprotein (2) P2X Receptor (1) P2Y Receptor (1) p38 MAPK (12) Parasite (15) PARP (16) PDHK (2) PERK (2) PGE synthase (1) Phosphodiesterase (PDE) (4) PI3K (11) Pim (1) PKC (3) Potassium Channel (2) PPAR (3) PROTACs (1) Protease Activated Receptor (PAR) (1) Proteasome (3) Pyroptosis (1) Raf (1) Ras (2) Reactive Oxygen Species (ROS) (22) Reference Standards (27) Ribosomal S6 Kinase (RSK) (1) Ser/Thr Protease (1) Sirtuin (3) Small Interfering RNA (siRNA) (3) Sodium Channel (1) Src (1) STAT (5) Survivin (2) TGF-beta/Smad (2) TGF-β Receptor (1) Thymidylate Synthase (1) Tissue Factor Pathway Inhibitor (TFPI) (2) Toll-like Receptor (TLR) (1) Topoisomerase (7) TRP Channel (3) ULK (1) VD/VDR (2) VDAC (1) VEGFR (9) Wnt (1) β-catenin (4)
By Research Areas:	Cancer (206) Cardiovascular Disease (27) Endocrinology (5) Infection (33) Inflammation/Immunology (53) Metabolic Disease (20) Neurological Disease (26)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Aptamers (2) Rat Pre-designed siRNA Sets (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Polymers (1) siRNAs (3)

287

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5243

Copper tripeptide-3 AHK-Cu	Others Bcl-2 Family	Others
Copper tripeptide-3 (AHK-Cu) is a bioactive peptide with promotion of hair growth effect. Copper tripeptide-3 increases dermal cell proliferation and viability while increasing the deposition of collagen to renew the extracellular matrix. Copper tripeptide-3 stimulates the elongation of human hair follicles and proliferation of dermal papilla cells ^[2].

HY-122760

Bax activator-1 2 Publications Verification	Bcl-2 Family Apoptosis	Cancer
Bax activator-1 (compound 106) is a *Bax* activator that induces Bax-dependent tumor cell apoptosis .

HY-157176

BAX-IN-1	Bcl-2 Family	Others
BAX-IN-1 is a potential, selective inhibitor of Bcl-2-associated X protein (BAX).

HY-P0081

Bax inhibitor peptide V5 15+ Cited Publications BIP-V5; Bax Inhibiting Peptide V5	Bcl-2 Family Apoptosis	Cancer
Bax inhibitor peptide V5 (BIP-V5) is a *Bax*-mediated apoptosis inhibitor, used for cancer treatment.

HY-N1141

Torachrysone-8-O-b-D-glucoside	Others	Metabolic Disease
Torachrysone-8-O-b-D-glucoside could be isolated from root of Polygonum multiflorum. Torachrysone-8-O-b-D-glucoside increases the proliferation of DPCs (dermal papilla cells) .

HY-105844

Albutoin Bax 422Z	Drug Derivative	Neurological Disease
Albutoin (BAX 422Z), an anticonvulsant agent, is a thiohydantoin derivative used for the research of grand mal epilepsies .

HY-103271

Bax inhibitor peptide, negative control	Bcl-2 Family	Cancer
Bax inhibitor peptide, negative control is a inhibitor of *Bax. Bax* inhibitor peptide, negative control inhibits Bax translocation to mitochondria and Bax-mediated apoptosis in vitro .

HY-119682

Bax agonist 1	Bcl-2 Family Apoptosis	Cancer
Bax agonist 1 (compound SMBA2) is a *Bax* agonist (K_i=57.2 nM). Bax agonist 1 induces *Bax* conformational changes by blocking S184 phosphorylation, promoting *Bax* insertion into the mitochondrial membrane and forming *Bax* oligomers, which induce cytochrome c release and apoptosis in malignant cancer cells expressing *Bax. Bax* agonist 1 can be used in lung cancer research .

HY-174776

*Human BAX* mRNA**	mRNA	Cancer
Human BAX mRNA encodes the human BCL2 associated X, apoptosis regulator (BAX) protein, a member of the BCL2 protein family. BAX forms a heterodimer with BCL2, and functions as an apoptotic activator. It also plays a role in the mitochondrial apoptotic process.

HY-P2466

Bax BH3 peptide (55-74), wild type	Apoptosis	Cancer
Bax BH3 peptide (55-74), wild type is a 20-amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models .

HY-RS01376

Bax Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bax Rat Pre-designed siRNA Set A contains three designed siRNAs for Bax gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bax Rat Pre-designed siRNA Set A Bax Rat Pre-designed siRNA Set A

HY-RS01375

Bax Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bax Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bax gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bax Mouse Pre-designed siRNA Set A Bax Mouse Pre-designed siRNA Set A

HY-RS01374

BAX Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BAX Human Pre-designed siRNA Set A contains three designed siRNAs for BAX gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BAX Human Pre-designed siRNA Set A BAX Human Pre-designed siRNA Set A

HY-110031

BAI1 hydrochloride 5+ Cited Publications	Apoptosis Bcl-2 Family	Cancer
BAI1 hydrochloride is a selective apoptosis factor *BAX* allosteric inhibitors. BAI1 hydrochloride binds *BAX* and allosterically inhibits its activation. BAI1 hydrochloride has the potential to be used in the study of *BAX* dependent cell death-mediated diseases .

HY-112935

Nonacog alfa Bax326; Coagulation Factor IX [Recombinant]; BeneFIX	Ser/Thr Protease	Others
Nonacog alfa (BAX326) is a recombinant human factor IX that can be used for the research of haemophilia B .

HY-132173

GL0388	Bcl-2 Family	Cancer
GL0388 is a *Bax* activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC₅₀s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis. GL0388 suppresses breast cancer xenograft tumor growth in vivo .

HY-P99529

Valziflocept Bax1810; TAK-752	Fc Receptor (FcR)	Inflammation/Immunology
Valziflocept (BAX1810; TAK-752) is a recombinant soluble human FcγRIIb receptor that targets Fc and FcγR. FcγRs bind and neutralize pathogenic IgG, thus forming a "decoy" or "scavenger" receptor that can reduce the severity of autoimmune diseases. Valziflocept can be used in studies of autoimmune diseases such as systemic lupus erythematosus (SLE) .

HY-103269

BAI1 5+ Cited Publications	Bcl-2 Family Apoptosis	Cancer
BAI1 is a selective and allosteric inhibitor of *BAX, an apoptosis regulator. BAI1 directly binds to BAX* and allosterically inhibits BAX activation. BAI1 has the potential for the research of diseases mediated by BAX-dependent cell death .

HY-P99262

Imalumab Bax69; Anti-Human MIF Recombinant Antibody	Macrophage migration inhibitory factor (MIF)	Cancer
Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer .

HY-161242

CBI1	Bcl-2 Family	Cancer
CBI1 is a covalent *BAX* inhibitor. CBI1 selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 blocks t-2-hex lipidation and oligomerization of BAX. CBI1 inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex .

HY-101996

SMBA1	Bcl-2 Family	Cancer
SMBA1 is a potent *Bax* agonist with a K_i value of 43.3 nM. SMBA1 enhances the Bax expression. SMBA1 shows anti-tumor activity. SMBA1 has the potential for the research of lung cancer .

HY-147929

Apoptotic agent-3	Apoptosis Caspase Bcl-2 Family	Cancer
Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research .

HY-123054

BTSA1 1 Publications Verification	Bcl-2 Family Apoptosis	Cancer
BTSA1 is a potent, high affinity and orally active *BAX* activator with an IC₅₀ of 250 nM and an EC₅₀ of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to *BAX* leading to *BAX*-mediated apoptosis .

HY-111432

CCG-232601	Ras	Others
CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma .

HY-126311

4-Hydroxyresveratrol 3,4,5,4'-Tetrahydroxystibene	MDM-2/p53 Bcl-2 Family Apoptosis	Cancer
4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene), a Resveratrol (HY-16561) analog, differentially induces pro-apoptotic *p53/Bax* gene expression. 4-Hydroxyresveratrol induces apoptosis in SV40 virally transformed WI38 cells (WI38VA) cells, but not in WI38 cells. 4-Hydroxyresveratrol significantly induces the expression of p53, GADD45 and Bax genes and concomitantly suppresses the expression of bcl-2 gene in WI38VA .

HY-113365

Cholestenone 4-Cholesten-3-one	Endogenous Metabolite	Infection Metabolic Disease
Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice ^[2] .

HY-116198

15-PGDH-IN-2	15-PGDH	Metabolic Disease
15-PGDH-IN-2 (Compound 2) is a 15-PGDH inhibitor with an IC₅₀ value of 0.274 nM. 15-PGDH-IN-2 can be used in research on hair loss, bone formation, gastric ulcer healing, and dermal wound healing .

HY-147928

Apoptotic agent-2	Apoptosis Caspase Bcl-2 Family	Cancer
Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research .

HY-N1326

Santamarine Santamarin; Balchanin	Keap1-Nrf2	Inflammation/Immunology
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities ^[2].

HY-P5247A

Palmitoyl tetrapeptide-20 TFA PTP20 TFA	Melanocortin Receptor Sirtuin	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 TFA promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce *H₂O₂* accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 TFA can be used in research on preventing hair loss and improving hair graying .

HY-P5247

Palmitoyl tetrapeptide-20 PTP20	Melanocortin Receptor Sirtuin	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce *H₂O₂* accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 can be used in research on preventing hair loss and improving hair graying .

HY-147906

Anticancer agent 71	Apoptosis PARP	Cancer
Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity .

HY-117078

Justicidin A	Apoptosis	Cancer
justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer .

HY-N1190

DL-Syringaresinol (±)-Syringaresinol	p38 MAPK AP-1 Bacterial	Infection
DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing MAPK/AP-1 signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv ^[2].

HY-N5033

17-Hydroxy sprengerinin C	Bcl-2 Family Caspase	Cancer
17-Hydroxy sprengerinin C (compound 10) is a glycoside compound isolated from rhizomes of Polygonatum sibiricum. 17-Hydroxy sprengerinin C possesses stronger anticancer activities. 17-Hydroxy sprengerinin C reduces the expression of Blc-2 and pro-caspase3 and increases the production of Bax .

HY-W004500

All-trans-retinal 1 Publications Verification	Endogenous Metabolite Apoptosis	Metabolic Disease
All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis .

HY-170787

TZEP7	EGFR Apoptosis Bcl-2 Family Caspase	Cancer
TZEP7 is an EGFR kinase inhibitior in cancer cells. TZEP7 exhibits cytotoxic effects against cancer cell lines and induces apoptosis. TZEP7 demonstrates downregulation of antiapoptotic Bcl-2, upregulation of pro-apoptotic Bax, and increases caspase levels. TZEP7 is promising for research of anticancer agent .

HY-153480

ARC19499 Bax499	Factor Xa Factor VIIa Tissue Factor Pathway Inhibitor (TFPI)	Others
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-153480A

ARC19499 sodium Bax499 sodium	Factor Xa Factor VIIa Tissue Factor Pathway Inhibitor (TFPI)	Others
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-117694

MK-8825	CGRP Receptor	Neurological Disease Inflammation/Immunology
MK-8825 is an orally active, potent and selective CGRP receptor antagonist, which shows concentration-dependent inhibition of Capsaicin (HY-10448)-evoked dermal blood flow with an EC₅₀ value of about 7.4 μM. MK-8825 inhibits CGRP-induced spontaneous nociceptive facial grooming behaviors, neuronal activation in the trigeminal nucleus, and systemic release of pro-inflammatory cytokines in a mouse model of acute orofacial masseteric muscle pain. MK-8825 is promising for research of acute migraine ^[2].

HY-117136

AN-7	HDAC Caspase Bcl-2 Family	Cancer
AN-7 is an orally active histone deacetylase (HDAC) inhibitor that induces histone hyperacetylation and differentiation in vitro and in vivo, and inhibits the proliferation of human prostate 22Rv1 cancer cells. AN-7 can increase the expression of the pro-apoptotic protein *Bax, reduce the expression of the anti-apoptotic* protein *Bcl-2, and promote apoptosis* by activating caspase-3, and can be used in the study of prostate cancer .

HY-N2342

Procyanidin C1 5+ Cited Publications PCC1	Apoptosis	Cancer
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice ^[2].

HY-106258

Atilmotin OHM 11638; Bax-ACC 1638; MOT 288	Motilin Receptor	Metabolic Disease
OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pK_d of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents ^[2].

HY-105930

Lobaplatin 4 Publications Verification D-19466	Apoptosis Caspase Bcl-2 Family	Cancer
Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer ^[2] .

HY-161242A

CBI1 formic	Bcl-2 Family	Cancer
CBI1 formic is a covalent BAX inhibitor. CBI1 formic selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 formic blocks t-2-hex lipidation and oligomerization of BAX. CBI1 formic inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex .

HY-120035

DD1	Proteasome Ribosomal S6 Kinase (RSK) Apoptosis	Cancer
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation .

HY-N2342R

Procyanidin C1 (Standard) PCC1 (Standard)	Reference Standards Apoptosis	Cancer
Procyanidin C1 (Standard) is the analytical standard of Procyanidin C1. This product is intended for research and analytical applications. Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice ^[2].

HY-170449

E3 ligase Ligand 48	Ligands for E3 Ligase	Others
E3 ligase Ligand 48 is a CRBN ligand for PROTAC AR Degrader-9 (HY-170448). PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC₅₀ of 262.38 nM .

HY-12366

Ubrogepant MK-1602	CGRP Receptor	Cardiovascular Disease Neurological Disease
Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine ^[2].

HY-126185

Nibroxane	Antibiotic Bacterial	Infection
Nibroxane is an orally active antibacterial agent. Nibroxane can be metabolized to 2-methyl-5-nitro-m-dioxane in mice .

Cat. No.	Product Name	Type

HY-D1005A10

Poloxamer 184 (L64)

PEG-PPG-PEG, 2900 (Averag)

Co-solvents

Poloxamer 184 L64 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2900. Poloxamer 184 L64 exhibts short-term dermal toxicity characterized by slight erythema and intradermal inflammatory response. Poloxamer 184 L64 exhibits antimicrobial activity, that inihibits 60% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 184 L64 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering ^[2].

HY-W250111

Carboxymethyl chitosan

Biochemical Assay Reagents

Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma ^[2] .

HY-158226

Elastin Methacrylated

ElaMA

3D Bioprinting

Elastin Methacrylated (ElaMA) elastin recruits and modulates innate immune cells and accelerates angiogenesis at the wound site, thereby improving wound regeneration. Elastin Methacrylated attracts large numbers of neutrophils and primarily M2 macrophages to the wound and induces their penetration into the hydrogel. Elastin Methacrylated has excellent immunomodulatory effects, leading to superior angiogenesis, collagen deposition and dermal regeneration . Elastin Methacrylated needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.

HY-126437

Poly-L-lysine hydrobromide (MW 30000-70000)

1 Publications Verification

Drug Delivery

Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material ^[2] .

Cat. No.	Product Name	Target	Research Area

HY-P5243

Copper tripeptide-3 AHK-Cu	Peptides Bcl-2 Family	Others
Copper tripeptide-3 (AHK-Cu) is a bioactive peptide with promotion of hair growth effect. Copper tripeptide-3 increases dermal cell proliferation and viability while increasing the deposition of collagen to renew the extracellular matrix. Copper tripeptide-3 stimulates the elongation of human hair follicles and proliferation of dermal papilla cells ^[2].

HY-W129161

Acetyl tetrapeptide-3	Peptides	Metabolic Disease
Acetyl tetrapeptide-3 is a synthetic peptide. Acetyl tetrapeptide-3 enhances the adhesion of hair follicles to the scalp but also promotes the development of new hair follicles. Acetyl tetrapeptide-3 stimulates the synthesis of collagen III in hair follicles. Acetyl tetrapeptide-3 combined with Biochanin A (HY-14595) and ginseng extracts, can stimulate dermal papilla extracellular matrix (ECM) proteins by increasing hydroxyproline, Collagen Type 3, and laminin, yielding a significant improvement in hair follicle size and hair anchoring ^[2] .

HY-P0081

Bax inhibitor peptide V5 15+ Cited Publications BIP-V5; Bax Inhibiting Peptide V5	Bcl-2 Family Apoptosis	Cancer
Bax inhibitor peptide V5 (BIP-V5) is a *Bax*-mediated apoptosis inhibitor, used for cancer treatment.

HY-P5247

Palmitoyl tetrapeptide-20 PTP20	Melanocortin Receptor Sirtuin	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce *H₂O₂* accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 can be used in research on preventing hair loss and improving hair graying .

HY-P1928

Humanin	Bcl-2 Family	Neurological Disease Endocrinology
Humanin, an anti-apoptotic peptide of 24 amino acids, is a *Bax* inhibitor. Humanin prevents the translocation of *Bax* from cytosol to mitochondria, blocks *Bax* from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging ^[2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG ^[2].

HY-P0170

TB500 1 Publications Verification	Drug Derivative Akt P2X Receptor	Inflammation/Immunology
TB500 is a synthetic version of an active region of thymosin β₄. TB500 exhibits anti-fibrotic and wound healing activities by inhibiting the Akt signaling pathway and binding to actin. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation ^[2] .

HY-103271

Bax inhibitor peptide, negative control	Bcl-2 Family	Cancer
Bax inhibitor peptide, negative control is a inhibitor of *Bax. Bax* inhibitor peptide, negative control inhibits Bax translocation to mitochondria and Bax-mediated apoptosis in vitro .

HY-P2466

Bax BH3 peptide (55-74), wild type	Apoptosis	Cancer
Bax BH3 peptide (55-74), wild type is a 20-amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models .

HY-P5247A

Palmitoyl tetrapeptide-20 TFA PTP20 TFA	Melanocortin Receptor Sirtuin	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 TFA promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce *H₂O₂* accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 TFA can be used in research on preventing hair loss and improving hair graying .

HY-106258

Atilmotin OHM 11638; Bax-ACC 1638; MOT 288	Motilin Receptor	Metabolic Disease
OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pK_d of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents ^[2].

HY-P10993

CT20p	Bcl-2 Family	Cancer
CT20p is an anticancer peptide based on the C hydrophobic terminus of *Bax. CT20p has a unique cytotoxic effect independent of full-length Bax, and can act on mitochondria, leading to fusion-like aggregation and mitochondrial membrane hyperpolarization. CT20p can reduce α5β1* integrin levels and inhibit F-actin polymerization, thereby destroying the cytoskeleton and preventing cell attachment. CT20p can be used in the study of breast cancer .

HY-P5261

SA1-III KP1	Peptides	Metabolic Disease
SA1-III(KP1) is a bioactive peptide withanti-agingeffect and has been reported used as a cosmetic ingredient .

HY-P10186

Myristoylated ARF6 (2-13), scrambled	Peptides	Cardiovascular Disease
Myristoylated ARF6 (2-13), scrambled is a peptide , and is composed of amino acids 2–13 of ARF6 (MyrARF6 2–13) .

HY-P10614

Bid BH3 peptide	Apoptosis Bcl-2 Family	Others
Bid BH3 peptide is a small peptide derived from Bid protein that can bind and activate the pro-apoptotic proteins *Bax* and Bak, leading to mitochondrial outer membrane permeabilization (MOMP) and apoptosis. Bid BH3 peptide can be used to study mitochondrial bioenergetics .

HY-P3993

(Gly14)-Humanin (human) 14-Glycine-Humanin (human)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions ^[2].

HY-P3993A

(Gly14)-Humanin (human) acetate 14-Glycine-Humanin (human) acetate	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions ^[2].

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian ^[2].

HY-P5325

Bid BH3 (80-99)	Bcl-2 Family	Others
Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, *Bax, and reduces NF-κB, VCAM-1, MCP-1, and survivin. Propionyl-L-carnitine activates Src kinase, Akt, induces p-AMPK* and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis ^[2] .

Cat. No.	Product Name	Target	Research Area

HY-P99529

Valziflocept Bax1810; TAK-752	Fc Receptor (FcR)	Inflammation/Immunology
Valziflocept (BAX1810; TAK-752) is a recombinant soluble human FcγRIIb receptor that targets Fc and FcγR. FcγRs bind and neutralize pathogenic IgG, thus forming a "decoy" or "scavenger" receptor that can reduce the severity of autoimmune diseases. Valziflocept can be used in studies of autoimmune diseases such as systemic lupus erythematosus (SLE) .

HY-P99262

Imalumab Bax69; Anti-Human MIF Recombinant Antibody	Macrophage migration inhibitory factor (MIF)	Cancer
Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer .

HY-112935

Nonacog alfa Bax326; Coagulation Factor IX [Recombinant]; BeneFIX	Ser/Thr Protease	Others
Nonacog alfa (BAX326) is a recombinant human factor IX that can be used for the research of haemophilia B .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1141

Torachrysone-8-O-b-D-glucoside	Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Plants Disease Research Fields	Others
Torachrysone-8-O-b-D-glucoside could be isolated from root of Polygonum multiflorum. Torachrysone-8-O-b-D-glucoside increases the proliferation of DPCs (dermal papilla cells) .

HY-113365

Cholestenone 4-Cholesten-3-one	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice ^[2] .

HY-W004500

All-trans-retinal 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis .

HY-N2342

Procyanidin C1 5+ Cited Publications PCC1	Structural Classification Classification of Application Fields Source classification Rosaceae Crataegus pinnatifida Bge. Plants Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Cancer	Apoptosis
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice ^[2].

HY-W042156

Aegeline	Alkaloids Structural Classification Other Alkaloids Source classification Rutaceae Plants Aegle marmelos (L.) Correa	Fungal
Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity .

HY-W745164

3,3′-Bisdemethylpinoresinol	Structural Classification Source classification Lignans Rubiaceae Morinda citrifolia Linn. Phenylpropanoids Plants	MMP
3,3′-Bisdemethylpinoresinol, lignin, is a nature product and has MMP-1 inhibitory activity in UVA-irradiated human dermal fibroblasts. 3,3′-Bisdemethylpinoresinol can be isolated from the seeds of Morinda citrifolia .

HY-N1326

Santamarine Santamarin; Balchanin	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Magnoliaceae Plants Inflammation/Immunology Disease Research Fields Magnolia grandiflora L.	Keap1-Nrf2
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities ^[2].

HY-N1190

DL-Syringaresinol (±)-Syringaresinol	Structural Classification Source classification Lignans Phenylpropanoids Plants Lauraceae Lindera akoensis Hay.	p38 MAPK AP-1 Bacterial
DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing MAPK/AP-1 signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv ^[2].

HY-N2342R

Procyanidin C1 (Standard) PCC1 (Standard)	Structural Classification Flavonoids Source classification Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Biflavones	Reference Standards Apoptosis
Procyanidin C1 (Standard) is the analytical standard of Procyanidin C1. This product is intended for research and analytical applications. Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice ^[2].

HY-N12653

Exserohilone (-)-Exserohilone	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Reactive Oxygen Species (ROS)
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

HY-N6573

Bufarenogin	Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Apoptosis Bcl-2 Family
Bufarenogin induces intrinsic apoptosis via *Bax* and ANT cooperation .

HY-N5123

α-L-Rhamnose	Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides Monosaccharides	Others
α-L-Rhamnose is a terminal residue of steviol glycosides Dulcoside A and Dulcoside B. α-L-Rhamnose recognizing lectin site of human dermal fibroblasts functions as a signal transducer: modulation of Ca ²⁺ fluxes and gene expression ^[2].

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Bcl-2 Family Caspase
Thevetiaflavone could upregulate the expression of *Bcl-2* and downregulate that of *Bax* and caspase-3.

HY-W042156R

Aegeline (Standard)	Alkaloids Structural Classification Other Alkaloids Source classification Rutaceae Plants Aegle marmelos (L.) Correa	Reference Standards Fungal
Aegeline (Standard) is the analytical standard of Aegeline. This product is intended for research and analytical applications. Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity .

HY-N2638R

Ilexsaponin A (Standard)	Aquifoliaceae Triterpenes Structural Classification Terpenoids Source classification Ilex pubescens Hook. et Arn. Plants	Reference Standards Apoptosis
Ilexsaponin A (Standard) is the analytical standard of Ilexsaponin A. This product is intended for research and analytical applications. Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

HY-N2638

Ilexsaponin A	Cardiovascular Disease Aquifoliaceae Triterpenes Classification of Application Fields Terpenoids Source classification Ilex pubescens Hook. et Arn. Plants Disease Research Fields	Apoptosis
Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through *anti-apoptotic* pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

HY-N15136

Isomorellinol	Structural Classification Xanthones Guttiferae Source classification Phenols Plants Garcinia hanburyi Hook. f.	Apoptosis
Isomorellinol is a xanthone with an anticancer potency. Isomorellinol induces apoptosis in cholangiocarcinoma cells. Isomorellinol increases the Bax/Bcl-2 protein expression ratio and decreases survivin protein expression in cholangiocarcinoma cells .

HY-126741

Azadirachtin 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Azadirachta indica A. Juss. Plants Meliaceae Disease Research Fields Biological Pesticide Research Agricultural Research	Apoptosis Parasite NF-κB Bcl-2 Family Caspase
Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting *Bcl-2/Bax* ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells ^[2] .

HY-N0905

Ginsenoside Rh4	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Bcl-2 Family Caspase Apoptosis Autophagy Endogenous Metabolite
Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates *Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy*.

HY-D0835

Hydroxylapatite (25-45 μm) Hydroxyapatite (25-45 μm)	Structural Classification Natural Products Animals Classification of Application Fields Source classification Other Diseases Disease Research Fields	Biochemical Assay Reagents
Hydroxylapatite (Hydroxyapatite) (25-45 μm) is a natural form of calcium phosphate and is the main mineral component of bones and teeth. Hydroxylapatite (25-45 μm) can stimulate the expression and secretion of collagen in primary human dermal fibroblasts. Hydroxylapatite (25-45 μm) has good biocompatibility, bioactivity, and bone conductivity, making it suitable for targeted drug or nucleic acid delivery. Hydroxylapatite (25-45 μm) can be used in research on osteoarthritis, gout, and atherosclerosis ^[2].

HY-113365R

Cholestenone (Standard) 4-Cholesten-3-one (Standard)	Structural Classification Microorganisms Source classification Endogenous metabolite Steroids	Reference Standards Endogenous Metabolite
Clebopride (malate) (Standard) is the analytical standard of Clebopride (malate). This product is intended for research and analytical applications. Clebopride malate is a dopamine antagonist used in the study of functional gastrointestinal disorders.

HY-N5106

(E)-Flavokawain A 1 Publications Verification	Structural Classification Chalcones Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Apoptosis
(E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice .

HY-N9391

7,3′,5′-Trihydroxyflavanone	Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Dalbergia sissoo Plants Disease Research Fields Cancer	Apoptosis
7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, induces the apoptotic cell death of MCF-7 cells by increasing Bax expression level. 7,3′,5′-Trihydroxyflavanone also exhibits antioxidant activity ^[2].

HY-12048

Chelerythrine chloride 15+ Cited Publications	Alkaloids Structural Classification Chelidonium majus Classification of Application Fields Source classification Metabolic Disease Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae	PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC₅₀ of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

HY-100354

C16-Ceramide 3 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	MDM-2/p53 Apoptosis Endogenous Metabolite
C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding .

HY-N5106R

(E)-Flavokawain A (Standard)	Structural Classification Chalcones Monophenols Flavonoids other families Source classification Phenols Plants	Reference Standards Apoptosis
(E)-Flavokawain A (Standard) is the analytical standard of (E)-Flavokawain A. This product is intended for research and analytical applications. (E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice .

HY-N10313

Dehydrobruceine B	Structural Classification Natural Products Microorganisms Source classification	Bcl-2 Family Keap1-Nrf2 Apoptosis
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and *Bax* expression and suppresses *Keap1-Nrf2* .

HY-N2067

Vanillyl alcohol p-(Hydroxymethyl)guaiacol	Structural Classification Monophenols Microorganisms Gastrodia elata Bl. Classification of Application Fields Orchidaceae Source classification Other Diseases Phenols Plants Disease Research Fields	Reactive Oxygen Species (ROS) Bcl-2 Family
Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses *Bax, increases Bcl-2*. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages ^[2] .

HY-N0831

Jaceosidin 5 Publications Verification	Laburnum anagyroides Medic. Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Bcl-2 Family COX Apoptosis
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates *Bax* and down-regulates Mcl-1 and c-FLIP expression . Jaceosidin exhibits anti-cancer ^[2], anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses *COX-2* expression and NF-κB activation .

HY-12048R

Chelerythrine chloride (Standard)	Alkaloids Structural Classification Chelidonium majus Source classification Plants Isoquinoline Alkaloids Papaveraceae	Reference Standards PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine (chloride) (Standard) is the analytical standard of Chelerythrine (chloride). This product is intended for research and analytical applications. Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC₅₀ of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

HY-N0292

Oleuropein 4 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Anti-aging Source classification Plants Burseraceae Iridoids Canarium album (Lour.) Rauesch. Terpenoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Cytochrome P450 PPAR Apoptosis
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase ^[2].

HY-N2038

3,5,6,7,8,3',4'-Heptemthoxyflavone	Structural Classification Flavonols Flavonoids Rutaceae Plants Citrus reticulata Blanco	Phosphodiesterase (PDE)
3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma ^[2] .

HY-N1414A

3′,6-Disinapoylsucrose 1 Publications Verification	Structural Classification Natural Products Polymer products Plants Brassicaceae Raphanus sativus Linn.	Bcl-2 Family Apoptosis
3′,6-Disinapoylsucrose is a type of oligosaccharide that's effective when taken orally, and it has antidepressant, anti-anxiety, and antioxidant properties. 3′,6-Disinapoylsucrose inhibits neuronal apoptosis by lowering the ratio of Bax to *Bcl-2* in hippocampal neurons, and it enhances cognitive function in APP/PS1 transgenic mice by activating the CREB/BDNF signaling pathway ^[2].

HY-N1440

Koumine	Alkaloids Structural Classification Classification of Application Fields Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Inflammation/Immunology Disease Research Fields Indole Alkaloids	Bcl-2 Family
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models ^[2].

HY-N1930

(-)-Hinesol Hinesol	Structural Classification Natural Products Plants Compositae Erythrina sigmoidea Hua	Apoptosis
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer .

HY-N2359

Chelerythrine	Alkaloids Structural Classification Classification of Application Fields Source classification Metabolic Disease Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae	Beta-lactamase PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity ^[2]. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy .

HY-167825

Barakol	Seeds of Cassia tora Linn. Structural Classification Natural Products Leguminosae Source classification Plants	MMP Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects ^[2] .

HY-N0307

Ciwujianoside B	Triterpenes Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Bcl-2 Family
Ciwujianoside B is isolated from Eleutherococcus senticosus leaf, is able to penetrate and work in the brain after the oral administration. Ciwujianoside B significantly enhances object recognition memory . Ciwujianoside B shows radioprotective effects on the hematopoietic system in mice, which is associated with changes in the cell cycle, reduces DNA damage and down-regulates the ratio of *Bax/Bcl-2* in bone marrow cells exposed to radiation ^[2].

HY-138875

Tetraacetylphytosphingosine	Structural Classification Natural Products Microorganisms Source classification	p38 MAPK Apoptosis
Tetraacetylphytosphingosine is a sphingolipid metabolite produced by phytosphingosine acetylation. Tetraacetylphytosphingosine exerts its inhibitory action on angiogenesis through the inhibition of MAPK activation and intracellular calcium increase . Tetraacetylphytosphingosine induces apoptosis in HaCaT cells ^[2].

HY-N0831R

Jaceosidin (Standard)	Laburnum anagyroides Medic. Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Plants Compositae Inflammation/Immunology Disease Research Fields	Reference Standards Bcl-2 Family COX Apoptosis
Jaceosidin (Standard) is the analytical standard of Jaceosidin. This product is intended for research and analytical applications. Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates *Bax* and down-regulates Mcl-1 and c-FLIP expression . Jaceosidin exhibits anti-cancer ^[2], anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses *COX-2* expression and NF-κB activation .

HY-N0361

Dihydrocapsaicin 2 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Source classification Phenols Metabolic Disease Solanaceae Plants Disease Research Fields	TRP Channel Reactive Oxygen Species (ROS) Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, *Bax, and Caspase-3* expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-N0867

13-Oxyingenol-13-dodecanoate	Structural Classification Classification of Application Fields Terpenoids Gramineae Source classification Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields	HIV ULK Bcl-2 Family
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of *BAX* and suppresses the expression of *BCL-2* to effect apoptosis ^[2].

HY-N0292R

Oleuropein (Standard)	Structural Classification Iridoids Canarium album (Lour.) Rauesch. Terpenoids Source classification Phenols Polyphenols Plants Burseraceae	Cytochrome P450 Reference Standards PPAR Apoptosis
Oleuropein (Standard) is the analytical standard of Oleuropein. This product is intended for research and analytical applications. Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase ^[2].

HY-N1440R

Koumine (Standard)	Alkaloids Structural Classification Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids	Reference Standards Bcl-2 Family
Koumine (Standard) is the analytical standard of Koumine. This product is intended for research and analytical applications. Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models ^[2].

HY-N2877

Annonacin	Structural Classification Natural Products Neurological Disease Classification of Application Fields Annona muricata Linn. Source classification Plants Annonaceae Disease Research Fields	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W ^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways ^[2] .

HY-N0674A

Dehydrocorydaline chloride 35+ Cited Publications 13-Methylpalmatine chloride	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of *Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities ^[2]. Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain .

HY-N2067R

Vanillyl alcohol (Standard) p-(Hydroxymethyl)guaiacol (Standard)	Structural Classification Monophenols Microorganisms Gastrodia elata Bl. Orchidaceae Source classification Phenols Plants	Reference Standards Reactive Oxygen Species (ROS) Bcl-2 Family
Vanillyl alcohol (Standard) is the analytical standard of Vanillyl alcohol (HY-N2067). This product is intended for research and analytical applications. Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses *Bax, increases Bcl-2*. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages ^[2] .

HY-N0674B

Dehydrocorydaline (hydroxyl) 35+ Cited Publications 13-Methylpalmatine (hydroxyl)	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N15424

Himachalol	Structural Classification Cedrus deodara (Roxburgh) G. Don Pinaceae Terpenoids Sesquiterpenes Source classification Plants	Apoptosis Bcl-2 Family
Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level). Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD₅₀ of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.) ^[2].

HY-N0674

Dehydrocorydaline 35+ Cited Publications 13-Methylpalmatine	Infection Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of *Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities ^[2]. Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli Cell-free (1) E. coli (1)

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HY-P7651

	Bax Protein, Human (His) rHuBCL2L4, His; Apoptosis Regulator Bax; Bcl-2-Like Protein 4; BCL2L4; Bax	Human	E. coli
	Bax Protein, Human (His) suppresses tumorigenesis and stimulates apoptosis. BCL2L4 (BAX) is the proapoptotic members of the Bcl-2 family that are ubiquitously expressed in different tissues.

HY-P702614

	Bax Protein, Human (Cell-Free, His) rHuBCL2L4, His; Apoptosis Regulator Bax; Bcl-2-Like Protein 4; BCL2L4; Bax	Human	E. coli Cell-free
	Bax Protein, Human (Cell-Free, His) is the recombinant human-derived Bax, expressed by E. coli Cell-free, with N-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-50907S

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research ^[2] .

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃ is the deuterium labeled Dihydrocapsaicin (HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-N0060BS

(E)-Ferulic acid-d3

(E)-Ferulic acid-d₃ is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299 .

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-W713297

Moroxydine hydrochloride-d8

Moroxydine hydrochloride-d₈ (ABOB hydrochloride-d₈) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels ^[1][2][3].

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HY-P80028

	Bax Antibody (YA591) 3 Publications Verification	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	Bax Antibody (YA591) is a non-conjugated and Rabbit origined monoclonal antibody about 21 kDa, targeting to Bax. It can be used for WB,IF/ICC,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80027

	Bax Antibody (YA825) 2 Publications Verification Apoptosis regulator Bax; Bax; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4	WB, IHC-P	Human, Mouse, Rat
	Bax Antibody (YA825) is a non-conjugated and Mouse origined monoclonal antibody about 21 kDa, targeting to BAX. It can be used for WB, IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80564

	Bax Antibody (YA826) Apoptosis regulator Bax; Bax; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4	WB	Human, Monkey
	Bax Antibody (YA826) is a non-conjugated and Mouse origined monoclonal antibody about 21 kDa, targeting to Bax (2B12). It can be used for WB assays with tag free, in the background of Human, Monkey.

HY-P86515

	Bax Antibody (YA6207) Bax; BCL2L4; Apoptosis regulator Bax; Bcl-2-like protein 4; Bcl2-L-4	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bax Antibody (YA6207) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bax. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P84506

	Bax Antibody (YA4203) BCL2L4	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	Bax Antibody (YA4203) is a mouse-derived and non-conjugated IgG2a antibody, targeting to BAX. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human, mouse, rat, rabbit, monkey.

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Cat. No.	Product Name		Classification

HY-W001538

S-Propargylcysteine SPRC		Alkynes
S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H₂S-releasing compound. S-Propargylcysteine reduces Ca ²⁺ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties ^[2].

Cat. No.	Product Name		Classification

HY-153480A

ARC19499 sodium Bax499 sodium		Aptamers
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-126437

Poly-L-lysine hydrobromide (MW 30000-70000) 1 Publications Verification		Polymers
Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates *Bcl-2* and upregulates *Bax* and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material ^[2] .

HY-174776

*Human BAX* mRNA**		mRNA
Human BAX mRNA encodes the human BCL2 associated X, apoptosis regulator (BAX) protein, a member of the BCL2 protein family. BAX forms a heterodimer with BCL2, and functions as an apoptotic activator. It also plays a role in the mitochondrial apoptotic process.

HY-RS01376

Bax Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bax Rat Pre-designed siRNA Set A contains three designed siRNAs for Bax gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01375

Bax Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bax Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bax gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01374

BAX Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BAX Human Pre-designed siRNA Set A contains three designed siRNAs for BAX gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-153480

ARC19499 Bax499		Aptamers
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

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Dermal papilla cells,apoptotic,Bcl-2/Bax

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