Thianthrene

Cat. No.: HY-W014120 Purity: 99.97%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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Thianthrene is a potent and orally active inhibitor of Leishmania donovani pteridine reductase 1 (PTR1). Thianthrene is a sulfur-containing tricyclic molecule distributed widely within the macro-structure of hydrocarbon fossil fuels. Thianthrene inhibits the intracellular amastigotes of Leishmania donovani (IC₅₀ = 23 μM). Thianthrene has a moderate anthelmintic activity. Thianthrene appears to inhibit RNA function and subsequent protein production. Thianthrene can stimulate liver regeneration in vivo.

For research use only. We do not sell to patients.

Thianthrene Chemical Structure

CAS No. : 92-85-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Thianthrene:

Thianthrene (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Thianthrene (2-6 μg/mL) reduces the infection rate measured by MFI of macrophages^[2].
Thianthrene inhibits the intracellular amastigotes of L. donovani (IC₅₀ = 23 μM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Thianthrene (100-900 mg/kg, p.o., single dose) appears to have no toxicity in Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

216.33

Formula

C₁₂H₈S₂

CAS No.

92-85-3

Appearance

Solid

Color

White to light brown

SMILES

C12=CC=CC=C1SC3=C(C=CC=C3)S2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 11.11 mg/mL (51.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6226 mL	23.1128 mL	46.2257 mL
5 mM	0.9245 mL	4.6226 mL	9.2451 mL
10 mM	0.4623 mL	2.3113 mL	4.6226 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.11 mg/mL (5.13 mM); Clear solution

This protocol yields a clear solution of ≥ 1.11 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (11.1 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (286 KB) SDS (393 KB)

COA (250 KB) HNMR (127 KB) RP-HPLC (226 KB)

Handling Instructions (2659 KB)

References

[1]. Mitchell SC, et al. Fate of thianthrene in biological systems. Xenobiotica. 2017 Aug;47(8):731-740. [Content Brief]

[2]. Jaspreet Kaur, et al., (2021), Thianthrene is a novel inhibitor of Leishmania donovani pteridine reductase 1 (PTR1) Journal of Molecular Biochemistry

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6226 mL	23.1128 mL	46.2257 mL	115.5642 mL
	5 mM	0.9245 mL	4.6226 mL	9.2451 mL	23.1128 mL
	10 mM	0.4623 mL	2.3113 mL	4.6226 mL	11.5564 mL
	15 mM	0.3082 mL	1.5409 mL	3.0817 mL	7.7043 mL
	20 mM	0.2311 mL	1.1556 mL	2.3113 mL	5.7782 mL
	25 mM	0.1849 mL	0.9245 mL	1.8490 mL	4.6226 mL
	30 mM	0.1541 mL	0.7704 mL	1.5409 mL	3.8521 mL
	40 mM	0.1156 mL	0.5778 mL	1.1556 mL	2.8891 mL
	50 mM	0.0925 mL	0.4623 mL	0.9245 mL	2.3113 mL

Thianthrene Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thianthrene92-85-3Biochemical Assay ReagentsParasiteSulfur-containingheterocyclicdithiindermal infectionInhibitorinhibitorinhibit

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