Search Result

Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

human IgG2 antibody

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) Antibody-Drug Conjugates (ADCs) (1) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) ANGPTL (1) Apoptosis (4) c-Fms (1) c-Kit (1) CCR (1) CD2 (1) CD20 (2) CD22 (1) CD28 (2) CD3 (2) CRAC Channel (1) CTLA-4 (1) CXCR (2) E-Selectin (1) EGFR (5) Fc Receptor (FcR) (1) Galectin (1) GCGR (1) HSP (1) IGF-1R (1) Insulin Receptor (1) Integrin (6) Interleukin Related (15) MDM-2/p53 (1) MHC (2) Microtubule/Tubulin (1) MMP (1) NF-κB (1) Notch (2) P-glycoprotein (1) PD-1/PD-L1 (2) Prion Protein (1) Ras (1) Reactive Oxygen Species (ROS) (1) SARS-CoV (1) Tau Protein (1) TGF-beta/Smad (2) Thrombin (1) Tie (1) Tim3 (1) Tissue Factor Pathway Inhibitor (TFPI) (1) TNF Receptor (5) Transmembrane Glycoprotein (10) Trk Receptor (3) Tyrosinase (1) Wnt (1)
By Research Areas:	Cancer (40) Cardiovascular Disease (2) Infection (6) Inflammation/Immunology (70) Metabolic Disease (4) Neurological Disease (6)

By Targets:

ADC Antibody (1)

Antibody-Drug Conjugates (ADCs) (1)

Amyloid-β (1)

Anaplastic lymphoma kinase (ALK) (1)

ANGPTL (1)

Apoptosis (4)

c-Fms (1)

c-Kit (1)

CCR (1)

CD2 (1)

CD20 (2)

CD22 (1)

CD28 (2)

CD3 (2)

CRAC Channel (1)

CTLA-4 (1)

CXCR (2)

E-Selectin (1)

EGFR (5)

Fc Receptor (FcR) (1)

Galectin (1)

GCGR (1)

HSP (1)

IGF-1R (1)

Insulin Receptor (1)

Integrin (6)

Interleukin Related (15)

MDM-2/p53 (1)

MHC (2)

Microtubule/Tubulin (1)

MMP (1)

NF-κB (1)

Notch (2)

P-glycoprotein (1)

PD-1/PD-L1 (2)

Prion Protein (1)

Ras (1)

Reactive Oxygen Species (ROS) (1)

SARS-CoV (1)

Tau Protein (1)

TGF-beta/Smad (2)

Thrombin (1)

Tie (1)

Tim3 (1)

Tissue Factor Pathway Inhibitor (TFPI) (1)

TNF Receptor (5)

Transmembrane Glycoprotein (10)

Trk Receptor (3)

Tyrosinase (1)

Wnt (1)

By Research Areas:

Cancer (40)

Cardiovascular Disease (2)

Infection (6)

Inflammation/Immunology (70)

Metabolic Disease (4)

Neurological Disease (6)

Inhibitors & Agonists

MCE Kits

107

Inhibitory Antibodies

Antibodies

AMG-820	c-Fms	Cancer
AMG-820 is a fully human IgG2 antibody that targets CSF-1R. AMG-820 inhibits binding of the ligands CSF1 and IL34 and subsequent ligand-induced receptor activation. The isotype control for AMG-820 can refer to Human IgG2 kappa, Isotype Control (HY-P99002) .

Panitumumab 1 Publications Verification ABX-EGF	EGFR	Cancer
Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer .

Panitumumab (anti-EGFR)	EGFR	Cancer
Panitumumab (anti-EGFR) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (anti-EGFR) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (anti-EGFR) can be used in the research of cancers, such as colon cancer .

Vantictumab 1 Publications Verification OMP-18R5	Wnt	Cancer
Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma .

Ersodetug RZ-358; XOMA 358	Insulin Receptor	Inflammation/Immunology
Ersodetug is an anti-INSR (insulin receptor) human IgG2 κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

Fulranumab	Trk Receptor	Neurological Disease
Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain .

Pacibekitug PF-04236921; TOUR-006	Interleukin Related	Inflammation/Immunology
HY-P990937 is an IL6-targeting IgG2κ type human antibody, the recommed isotype control is Human IgG2 kappa, Isotype Control (HY-P99002) .

Denrakibart GSK3858279	CCR	Inflammation/Immunology
HY-P990982 is an CCL17-targeting IgG2κ type human antibody, the recommed isotype control is Human IgG2 kappa, Isotype Control (HY-P99002) .

Panitumumab (powder) ABX-EGF (powder)	EGFR	Cancer
Panitumumab (ABX-EGF) (powder) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (powder) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (powder) can be used in the research of cancers, such as colon cancer .

Nolavetbart	Interleukin Related	Inflammation/Immunology
Nolavetbart is an anti-Canlupfam IL31RA human IgG2 κ monoclonal antibody .

Anti-TrkB/NTRK2 Antibody	Trk Receptor	Neurological Disease
Anti-TrkB/NTRK2 Antibody is a human antibody expressed in CHO cells, targeting TrkB. Anti-TrkB/NTRK2 Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

Befovacimab BAY 1093884	Thrombin Tissue Factor Pathway Inhibitor (TFPI)	Cardiovascular Disease
Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research .

Prezalumab AMG 557	Transmembrane Glycoprotein Interleukin Related	Inflammation/Immunology
Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targeting ICOSL. Prezalumab inhibits T cell activation and related immune responses by binding to ICOSL and blocking the interaction between ICOS and ICOSL. Prezalumab can be used in the research of autoimmune diseases and inflammatory diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002) .

Elranatamab PF-06863135	TNF Receptor	Inflammation/Immunology
Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

Brodalumab 3 Publications Verification AMG 827; KHK4827	Interleukin Related	Inflammation/Immunology
Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis .

Visilizumab Anti-human CD3E Recombinant antibody; HuM291	Apoptosis	Inflammation/Immunology Cancer
Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .

Brazikumab AMG 139; MEDI2070	Interleukin Related	Inflammation/Immunology
Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23, with a K_D of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease .

Ontamalimab SHP647	Integrin	Inflammation/Immunology
Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease .

Ascrinvacumab 2 Publications Verification Anti-ACVRL1 / ALK-1 Reference antibody (ascrinvacumab); PF-03446962; GT-90001C	Anaplastic lymphoma kinase (ALK)	Cancer
Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a K_d value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC) .

Glembatumumab	ADC Antibody	Cancer
Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .

Utomilumab PF 05082566	TNF Receptor	Inflammation/Immunology Cancer
Utomilumab (PF 05082566) is a fully human IgG2 agonist monoclonal antibody that selectively binds to 4-1BB/CD137. Utomilumab can be used in the research of tumors such as follicular and other CD20 ⁺ non-Hodgkin lymphomas .

Meplazumab	SARS-CoV	Infection
Meplazumab is a human IgG2 monoclonal antibody (mAb) targeting Basigin/CD147. Meplazumab can be used in COVID-19 pneumonia, Coronary artery disease and Malaria research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

Anti-LAP Antibody	TGF-beta/Smad	Inflammation/Immunology
Anti-LAP Antibody is a humanized antibody expressed in CHO cells, targeting LAP. The Anti-LAP Antibody features a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For isotype control of the Anti-LAP Antibody, you can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Anti-MICB Antibody	Transmembrane Glycoprotein	Inflammation/Immunology
The Anti-MICB Antibody is a humanized antibody expressed in CHO cells, targeting MICB. The Anti-MICB Antibody contains a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 143.66 kDa. The isotype control for the Anti-MICB Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

Anti-NOTCH1 Antibody	Notch	Inflammation/Immunology
The Anti-NOTCH1 Antibody is a CHO-expressed human antibody targeting NOTCH1. The Anti-NOTCH1 Antibody has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-NOTCH1 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Anti-NGF/bNGF Antibody AS2886401-00	Trk Receptor	Inflammation/Immunology
Anti-NGF/bNGF Antibody is a CHO-expressed humanized antibody that targets NGF/bNGF. Anti-NGF/bNGF Antibody has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.14 kDa. The isotype control for Anti-NGF/bNGF Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

Anti-MMP9 Antibody	MMP	Inflammation/Immunology
Anti-MMP9 Antibody is a CHO-expressed human antibody that targets MMP9. The Anti-MMP9 Antibody is composed of a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.76 kDa. For the isotype control of the Anti-MMP9 Antibody, you can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Glembatumumab vedotin 1 Publications Verification CDX-011; CR011-vcMMAE	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Glembatumumab vedotin (CDX-011) is an ADC comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects .

Tarextumab OMP 59R5; Anti-human NOTCH2 Recombinant antibody	Notch	Cancer
Tarextumab (OMP-59R5) is a cross-reactive, fully human IgG2 antibody that selectively inhibits Notch2 and Notch3 signaling. Tarextumab demonstrates broad-spectrum antitumor efficacy in xenograft models of epithelial tumors. Tarextumab can be used for the study of pancreatic cancer .

Anti-Orai1 Antibody	CRAC Channel	Inflammation/Immunology
Anti-Orai1 Antibody is a humanized antibody expressed in CHO cells that targets Orai1. The Anti-Orai1 Antibody has a huIgG2 heavy chain and a huλ light chain, with an predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-Orai1 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Anti-ANGPTL8 Antibody	ANGPTL	Inflammation/Immunology
Anti-ANGPTL8 Antibody is a CHO expressed human antibody targeting ANGPTL8. Anti-ANGPTL8 Antibody has a huIgG1-type heavy chain and a huκ-type light chain with a predicted molecular weight (MW) of 150 kDa. An isotype control for Anti-ANGPTL8 Antibody can be found in Human IgG2 kappa, Isotype Control (HY-P99002).

AMG-317	Interleukin Related	Inflammation/Immunology
AMG 317 is a humanized monoclonal anti-CD124/IL4R/IL-4Rα antibody. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002). AMG 317 can be used in research related to asthma .

Seribantumab SAR 256212; MM 121; Anti-human ERBB3/ErbB 3 Recombinant antibody	EGFR Apoptosis	Cancer
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .

FR104	CD28	Inflammation/Immunology
FR104 is a humanized antibody expressed in CHO cells that targets CD28. FR104 comprises a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for FR104 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

Sapelizumab	Interleukin Related	Inflammation/Immunology
Sapelizumab is a CHO-expressed humanized antibody targeting IL-6Ra/CD126. Sapelizumab has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Sapelizumab can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Catumaxomab	CD3	Cancer
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers .

NI-0701	CXCR	Inflammation/Immunology
NI-0701 is a humanized antibody expressed in CHO cells that targets CCL5/RANTES. NI-0701 has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for NI-0701 can be referenced as Human IgG2 lambda, Isotype Control (HY-P991206).

AMG-780	Tie	Cancer
AMG-780 is a fully human IgG2 antibody that targets angiopoietin 1 (Ang1) (IC₅₀ = 4.5 nM) and angiopoietin 2 (Ang2) (IC₅₀ = 0.06 nM). AMG-780 inhibits tumor growth in the Colo205 xenograft mouse model by inhibiting both Ang1 and Ang2. AMG-780 is indicated for the research of cancers such as colon cancer .

Anti-TNFRSF7/CD27 Antibody	TNF Receptor	Inflammation/Immunology
Anti-TNFRSF7/CD27 Antibody is a CHO-expressed human antibody targeting TNFRSF7/CD27. The Anti-TNFRSF7/CD27 Antibody contains huIgG2 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-TNFRSF7/CD27 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

ABX-IL8	CXCR Interleukin Related	Inflammation/Immunology
ABX-IL8 is a human-derived antibody expressed in CHO cells, targeting CXCL8/IL-8. ABX-IL8 contains a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 143.94 kDa. The isotype control for ABX-IL8 can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

AGS-67E	Transmembrane Glycoprotein	Inflammation/Immunology
AGS-67E is a humanized antibody expressed by CHO, targeting TSPAN26/CD37. AGS-67E has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 143.44 kDa. The isotype control for AGS-67E can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

AMG-108 MEDI 8968	Interleukin Related	Inflammation/Immunology
AMG-108 is a humanized antibody expressed in CHO cells, targeting IL-1R1/CD121a. AMG-108 is composed of a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.62 kDa. The isotype control for AMG-108 can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

CDX-1140	TNF Receptor	Cancer
CDX-1140 is a human IgG2 CD40 agonist antibody. CDX-1140 activates dendritic cells (DCs) and B cells and drives NF-kB stimulation in a CD40-expressing reporter cell line. CDX-1140 is independent of FcR binding and synergistic with native CD40L signaling. CDX-1140 has both direct and immune-mediated anti-tumor activity. CDX-1140 can be used for the study of lymphoma cancer and solid tumors .

Ivuxolimab	Interleukin Related	Cancer
Ivuxolimab is a fully human IgG2 agonist targeting OX40 (CD134), which selectively binds to the OX40 receptor on the surface of activated CD4 ⁺ and CD8 ⁺ T cells without inducing antibody-dependent cytotoxicity. Ivuxolimab can promote T cell proliferation, survival and cytokine (such as IFN-γ, IL-2) secretion, inhibit regulatory T cell function, and enhance anti-tumor immune response. Ivuxolimab can be used in the study of melanoma, hepatocellular carcinoma, head and neck squamous cell carcinoma, etc .

M6903	Tim3	Cancer
M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM). M6903 binds to TIM-3, blocking the binding of TIM-3 to phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9), thus relieving TIM-3-mediated T cell inhibition and exerting the activities of activating antigen-specific T cells and enhancing anti-tumor immunity. M6903 is promising for research of cancers .

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .

Cat. No.	Product Name

HY-K0214

Protein G Agarose 5 Publications Verification
MCE Protein G Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein G, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG3 and rat IgG2a.

Cat. No.	Product Name	Target	Research Area

HY-P991048

AMG-820	c-Fms	Cancer
AMG-820 is a fully human IgG2 antibody that targets CSF-1R. AMG-820 inhibits binding of the ligands CSF1 and IL34 and subsequent ligand-induced receptor activation. The isotype control for AMG-820 can refer to Human IgG2 kappa, Isotype Control (HY-P99002) .

HY-P99460

Bapotulimab BAY-1905254	Inhibitory Antibodies	Inflammation/Immunology Cancer
Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2). Bapotulimab has antitumor and immunosuppressive effects .

HY-P99041

Panitumumab 1 Publications Verification ABX-EGF	EGFR	Cancer
Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer .

HY-P99041A

Panitumumab (anti-EGFR)	EGFR	Cancer
Panitumumab (anti-EGFR) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (anti-EGFR) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (anti-EGFR) can be used in the research of cancers, such as colon cancer .

HY-P9974

Vantictumab 1 Publications Verification OMP-18R5	Wnt	Cancer
Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma .

HY-P991206

Human IgG2 lambda, Isotype Control	Inhibitory Antibodies	Inflammation/Immunology
Human IgG2 lambda, Isotype Control, a human monoclonal antibody, is an isotype control for human IgG2λ antibody .

HY-P99002

Human IgG2 kappa, Isotype Control	Inhibitory Antibodies	Inflammation/Immunology
Human IgG2 kappa, Isotype Control, a human monoclonal antibody, is an isotype control for human IgG2κ antibody .

HY-P990712

Ersodetug RZ-358; XOMA 358	Insulin Receptor	Inflammation/Immunology
Ersodetug is an anti-INSR (insulin receptor) human IgG2 κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99041B

Panitumumab (powder) ABX-EGF (powder)	EGFR	Cancer
Panitumumab (ABX-EGF) (powder) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (powder) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (powder) can be used in the research of cancers, such as colon cancer .

HY-P990732

Cepeprubart	Inhibitory Antibodies	Inflammation/Immunology
Cepeprubart is an anti-SELPLG human IgG2 κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990713

Nolavetbart	Interleukin Related	Inflammation/Immunology
Nolavetbart is an anti-Canlupfam IL31RA human IgG2 κ monoclonal antibody .

HY-P99200

Fulranumab	Trk Receptor	Neurological Disease
Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain .

HY-P990937

Pacibekitug PF-04236921; TOUR-006	Interleukin Related	Inflammation/Immunology
HY-P990937 is an IL6-targeting IgG2κ type human antibody, the recommed isotype control is Human IgG2 kappa, Isotype Control (HY-P99002) .

HY-P990982

Denrakibart GSK3858279	CCR	Inflammation/Immunology
HY-P990982 is an CCL17-targeting IgG2κ type human antibody, the recommed isotype control is Human IgG2 kappa, Isotype Control (HY-P99002) .

HY-P991098

Anti-TrkB/NTRK2 Antibody	Trk Receptor	Neurological Disease
Anti-TrkB/NTRK2 Antibody is a human antibody expressed in CHO cells, targeting TrkB. Anti-TrkB/NTRK2 Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99465

Befovacimab BAY 1093884	Thrombin Tissue Factor Pathway Inhibitor (TFPI)	Cardiovascular Disease
Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research .

HY-P99414

Prezalumab AMG 557	Transmembrane Glycoprotein Interleukin Related	Inflammation/Immunology
Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targeting ICOSL. Prezalumab inhibits T cell activation and related immune responses by binding to ICOSL and blocking the interaction between ICOS and ICOSL. Prezalumab can be used in the research of autoimmune diseases and inflammatory diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002) .

HY-P99909

Elranatamab PF-06863135	TNF Receptor	Inflammation/Immunology
Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P9925

Brodalumab 3 Publications Verification AMG 827; KHK4827	Interleukin Related	Inflammation/Immunology
Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis .

HY-P99332

Visilizumab Anti-human CD3E Recombinant antibody; HuM291	Apoptosis	Inflammation/Immunology Cancer
Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .

HY-P99485

Brazikumab AMG 139; MEDI2070	Interleukin Related	Inflammation/Immunology
Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23, with a K_D of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease .

HY-P990407

Anti-EPOR Antibody	Inhibitory Antibodies	Inflammation/Immunology
Anti-EPOR Antibody is a humanized antibody expressed in CHO, targeting EPOR. The predicted molecular weight (MW) of Anti-EPOR Antibody is 150 kDa. The isotype control for Anti-EPOR Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99411

Ontamalimab SHP647	Integrin	Inflammation/Immunology
Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease .

HY-P99353

Ascrinvacumab 2 Publications Verification Anti-ACVRL1 / ALK-1 Reference antibody (ascrinvacumab); PF-03446962; GT-90001C	Anaplastic lymphoma kinase (ALK)	Cancer
Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a K_d value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC) .

HY-P99205

Glembatumumab	ADC Antibody	Cancer
Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .

HY-P99265

Mapatumumab HGS-ETR1; Anti-human TNFRSF10A Recombinant antibody	Inhibitory Antibodies	Cancer
Mapatumumab (HGS-ETR1) is a fully human IgG2 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab can be used for the research of cancer .

HY-P99056

Utomilumab PF 05082566	TNF Receptor	Inflammation/Immunology Cancer
Utomilumab (PF 05082566) is a fully human IgG2 agonist monoclonal antibody that selectively binds to 4-1BB/CD137. Utomilumab can be used in the research of tumors such as follicular and other CD20 ⁺ non-Hodgkin lymphomas .

HY-P990388

Anti-CXADR Antibody	Inhibitory Antibodies	Inflammation/Immunology
Anti-CXADR Antibody is a humanized antibody expressed in CHO, targeting CXADR. The Anti-CXADR Antibody has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CXADR Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P991501

Meplazumab	SARS-CoV	Infection
Meplazumab is a human IgG2 monoclonal antibody (mAb) targeting Basigin/CD147. Meplazumab can be used in COVID-19 pneumonia, Coronary artery disease and Malaria research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990460

Anti-LAP Antibody	TGF-beta/Smad	Inflammation/Immunology
Anti-LAP Antibody is a humanized antibody expressed in CHO cells, targeting LAP. The Anti-LAP Antibody features a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For isotype control of the Anti-LAP Antibody, you can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990467

Anti-MICB Antibody	Transmembrane Glycoprotein	Inflammation/Immunology
The Anti-MICB Antibody is a humanized antibody expressed in CHO cells, targeting MICB. The Anti-MICB Antibody contains a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 143.66 kDa. The isotype control for the Anti-MICB Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990476

Anti-NOTCH1 Antibody	Notch	Inflammation/Immunology
The Anti-NOTCH1 Antibody is a CHO-expressed human antibody targeting NOTCH1. The Anti-NOTCH1 Antibody has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-NOTCH1 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990474

Anti-NGF/bNGF Antibody AS2886401-00	Trk Receptor	Inflammation/Immunology
Anti-NGF/bNGF Antibody is a CHO-expressed humanized antibody that targets NGF/bNGF. Anti-NGF/bNGF Antibody has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.14 kDa. The isotype control for Anti-NGF/bNGF Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990468

Anti-MMP9 Antibody	MMP	Inflammation/Immunology
Anti-MMP9 Antibody is a CHO-expressed human antibody that targets MMP9. The Anti-MMP9 Antibody is composed of a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.76 kDa. For the isotype control of the Anti-MMP9 Antibody, you can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990482

Anti-PAR2 Antibody	Inhibitory Antibodies	Inflammation/Immunology
The Anti-PAR2 Antibody is a human-derived antibody expressed in CHO cells, targeting PAR2. The Anti-PAR2 Antibody contains a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-PAR2 Antibody can be referred to as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990475

Anti-Nogo Receptor/NgR Antibody	Inhibitory Antibodies	Inflammation/Immunology
The Anti-Nogo Receptor/NgR Antibody is a CHO-expressed human antibody targeting Nogo Receptor/NgR. The Anti-Nogo Receptor/NgR Antibody contains huIgG2 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For the isotype control of Anti-Nogo Receptor/NgR Antibody, you may refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99320

Tarextumab OMP 59R5; Anti-human NOTCH2 Recombinant antibody	Notch	Cancer
Tarextumab (OMP-59R5) is a cross-reactive, fully human IgG2 antibody that selectively inhibits Notch2 and Notch3 signaling. Tarextumab demonstrates broad-spectrum antitumor efficacy in xenograft models of epithelial tumors. Tarextumab can be used for the study of pancreatic cancer .

HY-P990359

Anti-CD83 Antibody	Inhibitory Antibodies	Inflammation/Immunology
Anti-CD83 Antibody is a humanized antibody expressed in CHO cells that targets CD83. The Anti-CD83 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.8 kDa. The isotype control for Anti-CD83 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990478

Anti-Orai1 Antibody	CRAC Channel	Inflammation/Immunology
Anti-Orai1 Antibody is a humanized antibody expressed in CHO cells that targets Orai1. The Anti-Orai1 Antibody has a huIgG2 heavy chain and a huλ light chain, with an predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-Orai1 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990336

Anti-ANGPTL8 Antibody	ANGPTL	Inflammation/Immunology
Anti-ANGPTL8 Antibody is a CHO expressed human antibody targeting ANGPTL8. Anti-ANGPTL8 Antibody has a huIgG1-type heavy chain and a huκ-type light chain with a predicted molecular weight (MW) of 150 kDa. An isotype control for Anti-ANGPTL8 Antibody can be found in Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P991283

AMG-317	Interleukin Related	Inflammation/Immunology
AMG 317 is a humanized monoclonal anti-CD124/IL4R/IL-4Rα antibody. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002). AMG 317 can be used in research related to asthma .

HY-P99268

Seribantumab SAR 256212; MM 121; Anti-human ERBB3/ErbB 3 Recombinant antibody	EGFR Apoptosis	Cancer
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .

HY-P990587

FR104	CD28	Inflammation/Immunology
FR104 is a humanized antibody expressed in CHO cells that targets CD28. FR104 comprises a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for FR104 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990350

Anti-CD20 Antibody	Inhibitory Antibodies	Inflammation/Immunology
Anti-CD20 Antibody is a humanized antibody expressed in CHO that targets CD20/MS4A1. The Anti-CD20 Antibody is composed of huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CD20 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990662

Sapelizumab	Interleukin Related	Inflammation/Immunology
Sapelizumab is a CHO-expressed humanized antibody targeting IL-6Ra/CD126. Sapelizumab has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Sapelizumab can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P9954

Catumaxomab	CD3	Cancer
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers .

HY-P990668

TOL-101	Inhibitory Antibodies	Inflammation/Immunology
TOL-101 is a humanized antibody expressed in CHO cells that targets TCR. TOL-101 is composed of huIgG2 heavy chains and huκ light chains, with a predicted molecular weight (MW) of 125.6 kDa. The isotype control for TOL-101 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990638

NI-0701	CXCR	Inflammation/Immunology
NI-0701 is a humanized antibody expressed in CHO cells that targets CCL5/RANTES. NI-0701 has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for NI-0701 can be referenced as Human IgG2 lambda, Isotype Control (HY-P991206).

HY-P991663

AMG-780	Tie	Cancer
AMG-780 is a fully human IgG2 antibody that targets angiopoietin 1 (Ang1) (IC₅₀ = 4.5 nM) and angiopoietin 2 (Ang2) (IC₅₀ = 0.06 nM). AMG-780 inhibits tumor growth in the Colo205 xenograft mouse model by inhibiting both Ang1 and Ang2. AMG-780 is indicated for the research of cancers such as colon cancer .

HY-P990528

Anti-TNFRSF7/CD27 Antibody	TNF Receptor	Inflammation/Immunology
Anti-TNFRSF7/CD27 Antibody is a CHO-expressed human antibody targeting TNFRSF7/CD27. The Anti-TNFRSF7/CD27 Antibody contains huIgG2 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-TNFRSF7/CD27 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

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HY-P82451

	Human IgG2 Antibody (YA2196) IGHG2; immunoglobulin Gm2; immunoglobulin heavy constant gamma 2 (G2m marker)	WB, IHC-P, ICC/IF	Human
	Human IgG2 Antibody (YA2196) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Human IgG2.

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