Anti-Human/Mouse GRP78 Antibody (C38)

Cat. No.: HY-P990805 Purity: 95.00%: Data Sheet
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Anti-Human/Mouse GRP78 Antibody (C38) is a kind of mouse IgG2b antibody inhibitor, targeting to GRP78. Anti-Human/Mouse GRP78 Antibody (C38) inhibits RhoA, ROCK and AKT activation. Anti-Human/Mouse GRP78 Antibody (C38) can be used for the researches of cancer and metabolic disease, such as melanoma and diabetes.

For research use only. We do not sell to patients.

Anti-Human/Mouse GRP78 Antibody (C38) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Anti-Human/Mouse GRP78 Antibody (C38) Featured Recommendations:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Mouse IgG2b kappa

Recommend Isotype Controls

Mouse IgG2b kappa, Isotype Control

IC₅₀ & Target

GRP78

In Vitro

Anti-Human/Mouse GRP78 Antibody (C38) (2 μg) inhibits high glucose-induced RhoA and ROCK activation in mesangial cells^[1].
Anti-Human/Mouse GRP78 Antibody (C38) (30 mins) completely abrogates Akt activation in B16F1 melanoma cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Human/Mouse GRP78 Antibody (C38) (200 μg at an initial dose and 100 µg weekly for 12 weeks, i.p.) Attenuated RhoA activation in diabetic kidneys in type 1 diabetes mice models ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Type 1 diabetes mice models^[1]
Dosage:	200 μg at an initial dose and 100 µg weekly for 12 weeks
Administration:	Intraperitoneally injection
Result:	Attenuated RhoA activation in diabetic kidneys.

Gene ID

14828 [NCBI]

Accession

P20029

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Human/Mouse GRP78 Antibody (C38)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (260 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Soomro A, et al. Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease. Int J Mol Sci. 2021 Mar 11;22(6):2839. [Content Brief]

[2]. de Ridder GG, et al. A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. Melanoma Res. 2012 Jun;22(3):225-35. [Content Brief]

Anti-Human/Mouse GRP78 Antibody (C38) Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Human/Mouse GRP78 Antibody (C38)HSPHeat shock proteinsGRP78RhoAROCKAKTCancerMelanomaDiabetesInhibitorinhibitorinhibit

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