Search Result
Results for "
test
" in MedChemExpress (MCE) Product Catalog:
43
Biochemical Assay Reagents
7
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W011094
-
|
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Aldehyde Dehydrogenase (ALDH)
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Endocrinology
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Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes .
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-
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- HY-137367
-
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Cathepsin
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Infection
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Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins .
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-
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- HY-W193844
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Others
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Others
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MLS001006105 is used for biological test against the protein target: lamin isoform A-delta10 .
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- HY-121870A
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Larocaine hydrochloride
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Dopamine Receptor
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Neurological Disease
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Dimethocaine (Larocaine) hydrochloride is distributed and consumed as "new psychoactive substance" (NPS) without any safety testing
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-
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- HY-W011094R
-
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Aldehyde Dehydrogenase (ALDH)
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Endocrinology
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Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes .
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- HY-129807
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5-HT Receptor
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Neurological Disease
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LY-228729 is a selective 5-HT1A receptor agonist. LY-228729 can reduce the rearing frequency of rats and decrease their activity in the central area in the open field test. LY-228729 can reduce the immobility time of rats and increase their swimming time in the forced swim test. LY-228729 can be used in the research of neurological diseases .
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- HY-121345
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-
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- HY-157376
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Biochemical Assay Reagents
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Others
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Casein Agar can be used for casein decomposition test of Bacillus cereus. The composition of 1 liter of Casein Agar contains contains: 10.0 g casein, 3.0 g beef infusion powder, 5.0 g sodium chloride, 2.0 g dipotassium hydrogen phosphate and 15.0 g agar .
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- HY-157931
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Histamine Receptor
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Neurological Disease
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Anticancer agent 192 (compound XXI) is a steroid-based histamine H3 receptor antagonist with no affinity for muscarinics and hERG. Anticancer agent 192 is quite stable in human and rat liver microsomes. Anticancer agent 192 can improve the cognitive level and reduce the degree of addiction in rats in the in vivo addiction test .
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- HY-155330
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5-HT Receptor
Monoamine Oxidase
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Neurological Disease
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PZ-1922 (Compound 16) is a BBB-penetrable 5-HT6R/5-HT3R antagonist (Ki: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 reversibly inhibits MAO-B (pIC50: 8.93). PZ-1922 reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 prevents Aβ-induced memory decline in the T-maze test .
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- HY-155330A
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5-HT Receptor
Monoamine Oxidase
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Neurological Disease
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PZ-1922 free base is a BBB-penetrable 5-HT6R/5-HT3R antagonist (Ki: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 free base reversibly inhibits MAO-B (pIC50: 8.93). PZ-1922 free base reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 free base prevents Aβ-induced memory decline in the T-maze test .
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- HY-106507
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5-HT Receptor
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Neurological Disease
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Batoprazine (8-(1-piperazinyl)-2H-1-benzopyran-2-one)) is a 5-HT1A,1B receptor agonist. Batoprazine can replace the behavioral stimulus of eltoprazine in the two-lever operant discrimination test between eltoprazine and deionized water in rats (ED50: 0.20 mg/kg) .
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- HY-P1173
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Myristoylated L 803; GSK-3β Inhibitor XIII
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GSK-3
Amyloid-β
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Neurological Disease
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L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test .
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- HY-103216
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Adrenergic Receptor
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Neurological Disease
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RWJ52353 is a selective, orally active ligand for α2D adrenoceptor, which binds α2D, α2A, α2B and α1 receptors, with Kis of 1.5, 254, 621 and 443 nM. RWJ52353 exhibits analgesic efficacy in mouse abdominal irritation test (MAIT), with an ED50 of 15.1 mg/kg .
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- HY-W677042
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5α-Androst-16-en-3α-ol
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GABA Receptor
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Neurological Disease
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α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and human male axillary sweat. α-Androstenol is also a positive modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50=0.4 μM). α-Androstenol decreases immobility time in the forced swim test and increases time spent in the open arms of the elevated plus maze in mice. α-Androstenol protects against seizures induced by Pentylenetetrazole or electroshock with anxiolytic-like activity in mice .
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- HY-105977
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Others
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Inflammation/Immunology
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Chinoin 127 is a non anesthetic analgesic agent with strong anti-inflammatory activity. Chinoin 127 shows better analgesic effect than acetylsalicylic acid (ASA) in the hot plate test, Randall Selitto test, and torsion test .
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- HY-15913
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Biochemical Assay Reagents
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Others
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DAOS, a Trinder's reagent, is a novel highly water-soluble aniline derivative; are widely used in diagnostic tests and biochemical tests.
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- HY-B1610ER
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Trisodium citrate dihydrate, meets USP testing specifications (Standard)
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Reference Standards
Biochemical Assay Reagents
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Cardiovascular Disease
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Sodium citrate dihydrate, meets USP testing specifications (Standard) is the analytical standard of Sodium citrate dihydrate, meets USP testing specifications. This product is intended for research and analytical applications. Sodium citrate dihydrate, meets USP testing specifications is an anticoagulant and also used as a buffer and food preservatives .
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- HY-15918
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Biochemical Assay Reagents
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Others
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HDAOS is a novel Trinder's reagent, which is a highly water-soluble aniline derivative. HDAOS is widely used in diagnostic tests and biochemical tests .
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- HY-108903A
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Glycosidase
Biochemical Assay Reagents
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Endocrinology
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Hyaluronidase, Ovine testes is an endoglycosidase. Hyaluronidase, Ovine testes specifically degrades Hyaluronic acid (HY-B0633A) and Chondroitin sulfate (HY-B2162) by hydrolyzing β-glycosidic bonds in acidic mucopolysaccharides. Hyaluronidase, Ovine testes disperses follicular cells during fertilization by breaking down the hyaluronic acid-rich cumulus. Hyaluronidase, Ovine testes can be used in the study of fertility-related diseases .
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- HY-W795008
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Biochemical Assay Reagents
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Others
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Deoxyribonucleic acid, single stranded from salmon testes is a sodium salt of deoxyribonucleic acid from salmon testes that has been used in basal media for the anaerobic growth of several strains of Bacillus mojavei. Deoxyribonucleic acid, single stranded from salmon testes can also be used as a substrate for the development of DNA detection assays .
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- HY-21197
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Perfluoroheptanoic acid; Tridecafluoroheptanoic acid; PFHpA
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iGluR
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Neurological Disease
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Perfluoroenanthic acid (Perfluoroheptanoic acid) is a type of perfluoroalkyl substance (PFAS) that can negatively impact the development of seminiferous tubules and m6A RNA methylation in the testes of offspring mice when exposed during pregnancy, consequently disrupting spermatogenesis and leading to reproductive toxicity. Perfluoroenanthic acid alters the morphology of dendritic spines and synaptic formation in primary cortical neuron cultures, enhancing neuronal activity and synaptic transmission, and increasing the expression of excitatory synapse-related proteins Synaptophysin and PSD95 .
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- HY-B2243H
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Sodium phosphate monobasic (USP); Monosodium dihydrogen orthophosphate (USP); Monosodium phosphate (USP)
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Biochemical Assay Reagents
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Others
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Anhydrous sodium dihydrogen phosphate, meets USP testing specifications is an inorganic salt. It is a chemical compound of sodium with a phosphate counter ion. Anhydrous sodium dihydrogen phosphate, meets USP testing specifications can be used as a pH buffer with other sodium phosphates .
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- HY-W105639A
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Calcium lactate pentahydrate, meets USP testing specifications
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Biochemical Assay Reagents
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Others
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Calcium L-lactate pentahydrate, meets USP testing specifications (Calcium lactate pentahydrate, meets USP testing specifications) is a biochemical reagent and serves as one of the important sources of calcium. Compared to other organic calcium salts, Calcium L-lactate pentahydrate, meets USP testing specifications exhibits excellent solubility and bioavailability. Calcium L-lactate pentahydrate, meets USP testing specifications possesses remarkable moisture resistance, thermal stability, and chemical stability and can be used in medical implants and drug delivery systems .
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- HY-168535
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Ligands for E3 Ligase
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Cancer
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SJ6145 is a potent ligand for KLHDC2 SBD, with the Kd of 16.9 μM in SPR test, IC50 value of 42 μM in inhibiting KLHDC2 SBD binding to a di-Gly degron peptide test .
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- HY-W134423
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Biochemical Assay Reagents
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Others
Cancer
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Agar, microbiology tested, for cell culture (powder) is a jelly like substance that contains agarose and agar gel. Agar, microbiology tested, for cell culture (powder) can be isolated from the cell walls of red algae species such as Gelidium and Gracilaria (Ogonori). The gelation and melting of Agar, microbiology tested, for cell culture (powder) is based on the hydrogen bridge (physical gels), so the gelation is reversible. Agar, microbiology tested, for cell culture (powder) is widely used in food additives, plant tissue culture, microorganisms culture media, fingerprint recognition, and medical fields .
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- HY-135996
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Lipase
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Others
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Dilaurylglycerosulfate is a co-emulsifier in the diagnostic test for the determination of lipase.
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- HY-135996A
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Lipase
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Others
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Dilaurylglycerosulfate sodium is a co-emulsifier in the diagnostic test for the determination of lipase.
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- HY-B1493R
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Biochemical Assay Reagents
Reference Standards
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Endocrinology
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Bentiromide (Standard) is the analytical standard of Bentiromide. This product is intended for research and analytical applications. Bentiromide is a peptide that is broken down in the pancreas by chymotrypsin. The bentiromide test is an excellent means of confirming the diagnosis of pancreatic exocrine insufficiency by outpatient test of chymotrypsin function .
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- HY-W714505
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Opioid Receptor
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Neurological Disease
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AH 7563 structurally belongs to the opioid compounds and exhibits analgesic activity. In the phenylquinone test and hot plate test, the ED50 of AH 7563 for analgesia in mice were 15.3 mg/kg (orally) and 15.5 mg/kg (subcutaneous injection), respectively .
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- HY-W714509
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Opioid Receptor
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Neurological Disease
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AH 8507 structurally belongs to the opioid compounds and is an analog of AH 7563 (HY-W714505). However, AH 8507 does not exhibit significant analgesic effects in mice in both the phenylquinone test and the hot plate test, with ED50 values greater than 100 mg/kg .
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- HY-N5067
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Multifidin
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Others
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Inflammation/Immunology
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Rhodiocyanoside A is found to show antiallergic activity in a passive cutaneous anaphylaxis test in rat .
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- HY-W127350
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Liposome
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Metabolic Disease
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Cholesterol Pelargonate, a Cholesterol derivative, can be used as a triggered release liposome tested .
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- HY-B1908
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SF-837; Antibiotic SF-837
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Bacterial
Antibiotic
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Infection
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Midecamycin, an acetoxy-substituted macrolide antibiotic, is tested against gram-positive and gram-negative bacteria.
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- HY-177607
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- HY-Y0319B2
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- HY-129903R
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Drug Metabolite
Reference Standards
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Others
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N-Desethyl vardenafil (Standard) is the analytical standard of N-Desethyl vardenafil. This product is intended for research and analytical applications. N-Desethyl vardenafil is the major metabolite of Vardenafil (HY-B0442) and can be detected in human urine .
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- HY-129903
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Drug Metabolite
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Others
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N-Desethyl vardenafil is the major metabolite of Vardenafil (HY-B0442) and can be detected in human urine .
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- HY-A0080
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Sodium p-aminohippurate; p-Aminohippuric acid sodium salt
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Others
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Others
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Aminohippurate sodium is a diagnostic agent useful in medical tests involving the kidney used in the measurement of renal plasma flow.
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- HY-P10276
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Caspase
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Cancer
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Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .
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- HY-B1610E
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Trisodium citrate dihydrate, meets USP testing specifications
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Biochemical Assay Reagents
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Cardiovascular Disease
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Sodium citrate dihydrate, meets USP testing specifications is an anticoagulant and also used as a buffer and food preservatives .
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- HY-147735
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GABA Receptor
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Neurological Disease
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GABAA receptor agonist 1 (compound 3e) is a potent GABAA receptor agonist. GABAA receptor agonist 1 shows anti-depression activities in classical mouse models of depression of FST and TST. GABAA receptor agonist 1 binds at the GABA binding site of GABAA receptor in order to produce GABAergic effects. GABAA receptor agonist 1 has the potential for the research of depression .
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- HY-P4449
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Caspase
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Cancer
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Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
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- HY-W281713
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Fluorescein chloride
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Fluorescent Dye
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Others
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3,6-Dichlorofluorescein, a fluoresceina, can be used in the spot test for drugs containing amino and heterocyclic nitrogen .
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- HY-B1307
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Cytochrome P450
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Neurological Disease
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Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents.
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- HY-P4458
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Ser/Thr Protease
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Cancer
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Boc-QAR-pNA is a chromogenic substrate of trypsin. Boc-QAR-pNA can be used to test trypsin activity .
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- HY-135886
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Biochemical Assay Reagents
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Others
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2-Nitrophenyl α-D-galactopyranoside, a nitrophenyl derivative, is a substrate to test for hydrolytic activity of glycosyl hydrolase .
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- HY-P4476
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Ser/Thr Protease
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Others
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Suc-AAPA-pNA is a substrate of chymotrypsin Aα. Suc-AAPA-pNA can be used to test chymotrypsin Aα activity .
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- HY-D0236
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Fluorescent Dye
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Others
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Congo Red is an azo dye. Congo Red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections.
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-
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- HY-P4460
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Ser/Thr Protease
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Cancer
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AAA-pNA is a chromogenic substrate of Tripeptidyl-peptidase II. AAA-pNA can be used to test Tripeptidyl-peptidase II activity .
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- HY-W110917
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Biochemical Assay Reagents
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Others
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Dimethylsulfonazo III is a potent sulfate indicator. Dimethylsulfonazo III can be used as indicator to test those samples contaminated with potassium or phosphate ions .
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- HY-P4482
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Bacterial
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Infection
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Suc-AAPE-pNA is a chromogenic substrate of glutamyl endopeptidase. Suc-AAPE-pNA can be used to test glutamyl endopeptidase activity .
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- HY-P4455
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Bacterial
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Infection
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Boc-AAG-pNA is a glycine endopeptidase substrate. Boc-AAG-pNA can be used to test the amidase activity glycine endopeptidase .
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- HY-122997
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Others
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Others
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Acetylaleuritolic acid is a triterpenoid isolated from Jatropha curcas that exhibits tumor suppressive properties against the P-388 lymphocytic leukemia test system.
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- HY-W134423B
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Biochemical Assay Reagents
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Others
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Agar, meets USP testing specifications is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-Y0258
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- HY-172445
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SS-DNA
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Biochemical Assay Reagents
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Others
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Deoxyribonucleic acid sodium salt from salmon testes (ssstDNA) can be used to make anti-adhesion layers (AALs) for passivating gold plasmonic sensor surfaces .
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- HY-16997A
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JAK
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Cancer
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Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.
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- HY-164201
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- HY-W134020
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Semixylenol orange
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Biochemical Assay Reagents
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Others
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Semixylenol orange is a metallochromic indicator that can complex with various metal ions and is used for the testing and analysis of metal ions such as zinc and zirconium .
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- HY-W713878
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Caspase
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Others
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Ac-VDVAD-pNA is a caspase-2 substrate. Ac-VDVAD-pNA can be used to test the activity of caspase-2 .
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- HY-P10189
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- HY-P4449A
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Caspase
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Cancer
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Ac-VRPR-AMC TFA is a fluorogenic metacaspase substrate. Ac-VRPR-AMC TFA can be used to assay metacaspase activity .
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- HY-W040790
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Biochemical Assay Reagents
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Endocrinology
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2,6-Dimethylpyrazine is a key aroma compound. 2,6-Dimethylpyrazine can be isolated from Boletus edulis. 2,6-Dimethylpyrazine reduces seminal vesicle weight in rats. 2,6-Dimethylpyrazine can be used in food flavor and reproductive system research .
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- HY-W026842
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o-Benzoylbenzoic acid
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Drug Derivative
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Others
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2-Benzoylbenzoic acid is a Benzophenone (HY-Y0546) analog. 2-Benzoylbenzoic acid is non-phototoxic due to the alteration of the functional groups. 2-Benzoylbenzoic acid can be used to study the mechanism of phototoxicit .
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- HY-103216A
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Adrenergic Receptor
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Neurological Disease
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RWJ-52353 hydrochloride is an orally potent, highly selective α2D adrenergic receptor agonist (Ki: 1.5 nM) with potential analgesic effects. RWJ-52353 hydrochloride demonstrated analgesic activity in abdominal tests in rats and mice, and improved agitation in mice in the hot plate test and tail flick test. RWJ-52353 hydrochloride also regulates the organic cation transporter (OCT) subtype, inhibiting rOCT1 and rOCT2 with IC50s of 100 μM and 20 μM respectively; it also activates rOCT3, affecting [3H]-1- in cells. Methyl-4-phenylpyridinium ([3H]MPP) transport .
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- HY-P4464
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Ser/Thr Protease
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Cancer
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Ala-Phe-Pro-pNA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA can be used to test tripeptidyl peptidase activity .
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- HY-P4477
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Ser/Thr Protease
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Others
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Suc-AAPR-pNA is a substrate of trypsin acyl-enzymes. Suc-AAPR-pNA can be used to test trypsin acyl-enzymes activity .
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- HY-W134423A
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Biochemical Assay Reagents
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Others
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Agar, microbiology tested, for cell culture (granular) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-W087892
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Biochemical Assay Reagents
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Others
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Barium diphenylamine-4-sulfonate can be employed as an intermediate in pharmaceutical manufacturing and in chemical research, and serves as a dosing agent in analytical testing .
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- HY-D0158
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- HY-P4470
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Ser/Thr Protease
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Cancer
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Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .
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- HY-157366
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Biochemical Assay Reagents
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Others
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Sulfite Agar can be used for the test tube count of anaerobic Reductobacter sulfite. The composition of 1 litre medium is 31 g Sulfite Agar .
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- HY-121048
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Others
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Others
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AH 7725 is a sodium cromoglycate-like compound that is orally active and has the ability to inhibit (partially or completely) immediate asthmatic reactions in bronchial provocation tests for allergic asthma.
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- HY-17568
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Pelargonic acid vanillylamide; Nonanoic acid vanillylamide; Pseudocapsaicin
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TRP Channel
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Neurological Disease
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Nonivamide is a agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests.
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- HY-105127
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CGP 11305A hydrochloride
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Monoamine Oxidase
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Neurological Disease
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Brofaromine (hydrochloride) is a monoamine oxidase A (MAO-A) inhibitor and a 5-HT uptake inhibitor. Brofaromine (hydrochloride) shows antidepressant-like activity in the social conflict test in rats .
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- HY-118205
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Bacterial
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Infection
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SCH-538415 is a novel acyl carrier protein synthase inhibitor isolated from an unknown bacterial microorganism. The structural elucidation of compound 1 was completed by analyzing spectral data including UV, MS and 2D-NMR spectra. Compound 1 showed inhibitory activity in the acyl carrier protein synthase (AcpS) test with an IC50 value of 4.19 μM and exhibited antibacterial activity against Staphylococcus aureus in the agar diffusion test.
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- HY-W154117
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Drug Metabolite
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Others
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2,2-Dichloro-1,1-ethanediol is a metabolite of the insecticides Dichlorvos (HY-B1312) and Trichlorphon, is mutagenic in the Salmonella/microsome test.
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- HY-P4464A
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Ser/Thr Protease
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Cancer
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Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA TFA can be used to test tripeptidyl peptidase activity .
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- HY-157357
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Biochemical Assay Reagents
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Others
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Fungi Agar Medium can be used in sterile growth tests. Fungi Agar Medium ingredients include peptone, glucose, yeast powder, potassium dihydrogen phosphate, magnesium sulfate, and agar.
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- HY-P4475
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- HY-D0867
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Biochemical Assay Reagents
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Others
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BES is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES is used in the diagnostic testing area.
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- HY-D0867A
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Biochemical Assay Reagents
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Others
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BES sodium is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES sodium is used in the diagnostic testing area.
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- HY-169824
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- HY-12449
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LY3039478
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Notch
γ-secretase
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Cancer
|
|
Crenigacestat (LY3039478) is an orally active Notch and γ-secretase inhibitor, with an IC50 of 1 nM in most of the tumor cell lines tested .
|
-
- HY-161539
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
KOR agonist 1 (Compound 7a) is a selective agonist for opioid receptor, with EC50s of 3.4, 701.2 and 1649 nM, for KOR, MOR and DOR, respectively. KOR agonist 1 binds KOR, MOR and DOR, with Kis of 3.9, 1053 and 4196 nM, respectively. KOR agonist 1 exhibits antinociceptive effect in ICR mouse model (ED50 in hot plate test is 0.3 mg/kg, in abdominal constriction test is 0.2 mg/kg) .
|
-
- HY-W275039
-
|
2-Phenylbenzoquinone
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
Phenylquinone (2-Phenylbenzoquinone) causes pain and induces writhing in mice, and is often used in experiments to test the effectiveness of analgesics or agent that can suppress or relieve pain .
|
-
- HY-N4111R
-
|
|
Others
|
Inflammation/Immunology
Cancer
|
|
Wushanicaritin exhibits significant antioxidant activity (IC50=35.3 μM) in DPPH radical scavenging activity tests. Antitumor effects and anti-inflammatory property .
|
-
- HY-101410
-
SDMA
2 Publications Verification
Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine
|
Endogenous Metabolite
NO Synthase
NF-κB
|
Inflammation/Immunology
|
|
SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. SDMA, a novel kidney biomarker, permits earlier diagnosis of kidney disease than traditional creatinine testing.
|
-
- HY-N4111
-
|
|
Others
|
Inflammation/Immunology
Cancer
|
|
Wushanicaritin exhibits significant antioxidant activity (IC50=35.3 μM) in DPPH radical scavenging activity tests. Antitumor effects and anti-inflammatory property .
|
-
- HY-P4453
-
|
|
Caspase
|
Cancer
|
|
Boc-Ala-Ala-Asp-pNA is a chromogenic substrate of granzyme B. Boc-Ala-Ala-Asp-pNA can be used to test functional activity of granzyme B .
|
-
- HY-101241
-
|
|
mGluR
|
Neurological Disease
|
|
MPPG is a potent and selective L-AP4-sensitive receptor antagonist with an kD value of 9.2 μM, being tested on the neonatal rat spinal cord .
|
-
- HY-P0019
-
-
- HY-B1620
-
|
PVP K30; Polyvidone K30; Povidone K30
|
Biochemical Assay Reagents
|
Infection
|
|
Polyvinylpyrrolidone K30 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.
|
-
- HY-116108
-
|
Musk tibetine
|
Olfactory Receptor
|
Cancer
|
|
Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line .
|
-
- HY-D0830
-
|
Fluorexon tetraethyl ester
|
Fluorescent Dye
|
Others
|
|
Calcein tetraethyl ester is a fluorescent dye, is used in biology as it can be transported through the cellular membrane into live cells, which makes it useful for testing of cell viability and for short-term labeling of cells.
|
-
- HY-P0019A
-
|
|
Fluorescent Dye
Thrombin
|
Others
|
|
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
-
- HY-147736
-
|
|
GABA Receptor
|
Neurological Disease
|
|
GABAA receptor agonist 2 (compound 4c) is a potent GABAA receptor agonist. GABAA receptor agonist 2 shows anti-depression activities in classical mouse models of depression of FST and TST. GABAA receptor agonist 2 binds at the GABA binding site of GABAA receptor in order to produce GABAergic effects. GABAA receptor agonist 2 has the potential for the research of depression .
|
-
- HY-P10435
-
|
|
Dopamine Receptor
|
Neurological Disease
|
|
KEMPFPKYPVEP is a 12-amino acids neuropeptide, which upregulates levels of dopamine (DA) and norepinephrine (NE) in the prefrontal cortex, exhibits spatial and object recognition memory promoting ability in Scopolamine (HY-N0296)-induced amnesia mouse model .
|
-
- HY-118877
-
|
Carbonyl diamide-13C
|
Isotope-Labeled Compounds
|
Infection
|
|
Urea- 13C is the 13C labelled urea. The Urea- 13C breath test ( 13C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection .
|
-
- HY-153489A
-
|
ISIS-CRPRx sodium
|
C-type Lectin-like Receptors (CTLRs)
|
Cardiovascular Disease
|
|
ISIS 329993 sodium is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx sodium has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis
|
-
- HY-D0222
-
|
|
Fluorescent Dye
|
Others
|
|
N,N-Dimethyl-1-naphthylamine is an aromatic amine and a dye. N,N-Dimethyl-1-naphthylamine can be used in nitrate reduction test .
|
-
- HY-157349
-
|
BGLB
|
Biochemical Assay Reagents
|
Others
|
|
Brilliant Green Lactose Bile Broth can be used for confirmatory testing of coliform bacteria. The ingredients of Blood Enrichment Medium include tryptone, lactose, ox bile powder, and brilliant green .
|
-
- HY-112330
-
|
|
PKA
|
Neurological Disease
|
|
4-Cyano-3-methylisoquinoline is an inhibitor for protein kinase A (PKA) with an IC50 of micromolar level. 4-Cyano-3-methylisoquinoline reverses morphine tolerance in mouse model .
|
-
- HY-B1307R
-
|
|
Cytochrome P450
|
Neurological Disease
|
|
Zoxazolamine (Standard) is the analytical standard of Zoxazolamine. This product is intended for research and analytical applications. Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents.
|
-
- HY-125652
-
|
|
Antibiotic
|
Infection
|
|
Macrosphelide A is a macrolide antibiotic. Macrosphelide A inhibits growth of some ascomycetes, basidiomycetes, oomycetes and all four Gram-positive bacteria tested, including the medically important Staphylococcus aureus with a MIC of ≤500 μg/mL .
|
-
- HY-N15703
-
|
(+)-Norisocorydine
|
Others
|
Neurological Disease
|
|
Norisocorydine ((+)-Norisocorydine) is an aporphine alkaloid with antinociceptive and radical scavenging effects. Norisocorydine shows a SC50 of 14.1 μg/mL in DPPH radical scavenging test. Norisocorydine exhibits antinociceptive ability in mice .
|
-
- HY-Y0258S
-
-
- HY-153489
-
|
ISIS-CRPRx
|
C-type Lectin-like Receptors (CTLRs)
|
Cardiovascular Disease
|
|
ISIS 329993 (ISIS-CRPRx) is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis
|
-
- HY-Y0258S1
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Benzocaine-(ethyl-d5) is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
|
-
- HY-161924
-
|
|
HIV
|
Infection
|
|
HIV-1 inhibitor-73 (compound 13c) is a potent anti-HIV-1 agent, against the whole tested viral panel with EC50 ranging from 4.68 to 229 nM .
|
-
- HY-W039938
-
|
|
Fluorescent Dye
|
Others
|
|
4-Nitrophenyl β-D-xylopyranoside is a chromogenic β-xylosidase substrate. 4-Nitrophenyl β-D-xylopyranoside can be used to test β-xylosidase activity .
|
-
- HY-W013254
-
|
|
Glycosidase
|
Others
|
|
2-Nitrophenyl β-D-glucopyranoside is a substrate for β-glucosidase. 2-Nitrophenyl β-D-glucopyranoside can be used to test β-glucosidase activity .
|
-
- HY-114723
-
|
|
DNA/RNA Synthesis
|
Others
|
|
NPD9948 is an antitussive agent with antitussive activity in a guinea pig antitussive test. Its half antitussive dose (AtD50) is 14.5 mg/kg and 22.6 mg/kg when injected intraperitoneally and orally, respectively.
|
-
- HY-118285
-
|
|
mGluR
|
Neurological Disease
|
|
Ro4491533 is a selective, negative allosteric mGluR2/3 receptor modulator that is equally effective on both subtypes. Ro4491533 can completely block glutamate-induced calcium mobilization and glutamate-induced [35S]GTPγS binding accumulation. Ro4491533 has good pharmacokinetic properties in mice and rats, high oral bioavailability, and can pass through the blood-brain barrier. Ro4491533 can also reverse the motor inhibition effect of LY379268 in mice and show antidepressant activity in the forced swim test and tail suspension test.
|
-
- HY-139748
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
S32212 is a serotonin type 2C receptor inverse agonist and an α2 adrenoceptor antagonist. S32212 exhibits antidepressant activity and can reduce immobility time in forced-swim test in rats .
|
-
- HY-Y0258R
-
|
|
Reference Standards
Sodium Channel
Bacterial
|
Neurological Disease
|
|
Benzocaine (Standard) is the analytical standard of Benzocaine. This product is intended for research and analytical applications. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na + channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
|
-
- HY-106424
-
|
|
Others
|
Neurological Disease
|
|
Soretolide is an antiepileptic agent. Soretolide is effective in maximal electroshock-induced seizure (MES) test in rodents. Soretolide inhibits metabolism of Phenytoin (HY-B0448). Soretolide exhibits a good pharmacokinetic character in rats model .
|
-
- HY-170833
-
|
|
GABA Receptor
|
Neurological Disease
|
|
Anticonvulsant agent 8 (compound D4) is an anticonvulsant agent that inhibits GABAA currents with ED50 values of 2.23 and 24.60 mg/kg in the maximum electroshock (MES) and pentylenetetrazol (PTZ) tests in mouse models, respectively .
|
-
- HY-D1873
-
|
|
Fluorescent Dye
|
Others
|
|
800CW acid is an orally active near-infrared (NIR) dye (excitation/emission 774/789 nm). 800CW acid can be used for intestinal permeability testing. 800CW acid can be used for in vivo imaging studies .
|
-
- HY-122066
-
|
|
Others
|
Infection
|
|
NSC47924 is a laminin receptor (LR) inhibitor. NSC47924 affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein. NSC47924 can be used for testing prion diseases .
|
-
- HY-D0236R
-
|
|
Fluorescent Dye
|
Others
|
|
Congo Red (Standard) is the analytical standard of Congo Red. This product is intended for research and analytical applications. Congo Red is an azo dye. Congo Red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections.
|
-
- HY-N0006
-
-
- HY-N0006R
-
|
Curcumin II (Standard); Desmethoxycurcumin (Standard); Monodemethoxycurcumin (Standard)
|
Reference Standards
Apoptosis
Bacterial
Cholinesterase (ChE)
NO Synthase
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .
|
-
- HY-17568R
-
|
Pelargonic acid vanillylamide (Standard); Nonanoic acid vanillylamide (Standard); Pseudocapsaicin (Standard)
|
Reference Standards
TRP Channel
|
Neurological Disease
|
|
Nonivamide (Standard) is the analytical standard of Nonivamide. This product is intended for research and analytical applications. Nonivamide is a tests.
|
-
- HY-W040156
-
|
|
Fungal
|
Infection
|
|
Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process .
|
-
- HY-W293502
-
|
2-Chloro-4-nitrophenyl-beta-D-galactopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
2-Chloro-4-nitrophenyl-β-D-galactopyranoside is a chromogenic substrate used for testing enzyme activity. It is commonly used in molecular biology research to detect and measure the activity of β-galactosidase (biosynth: EC03318).
|
-
- HY-137425
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-Biotinyl-12-aminododecanoic acid is a compound formed by linking biotin and 12-aminododecanoic acid through an amide bond. N-Biotinyl-12-aminododecanoic acid is used as a biotinylation reagent to test the ligation activity of SimL .
|
-
- HY-P1771
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
OVA G4 peptide is a variant of the agonist ovalbumin (OVA) peptide SIINFEKL (257-264). SIINFEKL is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel .
|
-
- HY-153574
-
|
pArg-JQ1
|
PROTACs
Epigenetic Reader Domain
|
Infection
|
|
BI01826025 (pArg-JQ1) is a bromodomain1 of BRDT (BRDTBD1) PROTAC degrader. BI01826025 can be used for testing the regulatory effect of ClpC2 on the ClpC1P1P2 protease .
|
-
- HY-P10533
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Cysteine peptide is a heptapeptide containing a cysteine residue whose thiol group makes it susceptible to a range of oxidative modifications. Cysteine peptide is used to detect the skin sensitization potential of chemicals including cosmetic ingredients .
|
-
- HY-14336A
-
|
SB 271046A
|
5-HT Receptor
|
Neurological Disease
|
|
SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC50=0.16 μM) .
|
-
- HY-14336AR
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
SB 271046 (Hydrochloride) (Standard) is the analytical standard of SB 271046 (Hydrochloride). This product is intended for research and analytical applications. SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC50=0.16 μM) .
|
-
- HY-W010169
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Sodium 4-aminobenzoate is a biochemical assay reagent. According to its structure, sodium 4-aminobenzoate exhibits antioxidant, anticoagulant, fubrinolytic and immunomodulating activities, and can be utilized as a protective agent against UV-irradiation and in diagnostic tests for the state of the gastrointestinal tract .
|
-
- HY-156481
-
|
|
Cytochrome P450
|
Others
|
|
SU-8000 is an inhibitor that selectively targets 17α-hydroxylase and C17-20-lyase in rat testes. When administered to pregnant rats, SU-8000 can cause hypospadias in male fetuses .
|
-
- HY-126787
-
|
YP-02259L-C
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
17-Hydroxyventuricidin A (YP-02259L-C) is an antimicrobial compound.17-Hydroxyventuricidin A inhibits the growth of the two tested filamentous fungi (Verticillium dahlia and Fusarium sp.) and of Candida tropicalis R2 CIP203 .
|
-
- HY-19289
-
|
RWJ 54428
|
Bacterial
|
Infection
|
|
MC-02479 is a novel cephalosporin. RWJ-54428 has good activity against most of the organisms tested, including methicillin-resistant staphylococci, E. faecalis, and penicillin-resistant pneumococci, and has moderate activity against E. faecium .
|
-
- HY-W654381
-
-
- HY-P1771A
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
OVA G4 peptide TFA is a variant of the agonist ovalbumin (OVA) peptide SIINFEKL (257-264). SIINFEKL is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel .
|
-
- HY-162087
-
|
|
Bacterial
|
Infection
|
|
FabH-IN-2 (25), an antimicrobial agent, exhibits remarkable potential as an agent with an MIC range of 1.25-3.13 μg/mL against the tested bacterial strains and an IC50 of 2.0 μM against E. coli-derived FabH .
|
-
- HY-N4173R
-
|
|
Reference Standards
Drug Metabolite
|
Metabolic Disease
|
|
p-Dimethylaminobenzaldehyde (Standard) is the analytical standard of p-Dimethylaminobenzaldehyde. This product is intended for research and analytical applications. p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde) is an organic compound containing amine and aldehyde moieties which is used in Ehrlich's reagent and Kovac's reagent to test for indoles .
|
-
- HY-101410R
-
|
Symmetric dimethylarginine (Standard); NG,NG'-Dimethyl-L-arginine (Standard)
|
Reference Standards
Endogenous Metabolite
NO Synthase
NF-κB
|
Inflammation/Immunology
|
|
SDMA (Standard) is the analytical standard of SDMA. This product is intended for research and analytical applications. SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. SDMA, a novel kidney biomarker, permits earlier diagnosis of kidney disease than traditional creatinine testing.
|
-
- HY-Y1083H
-
|
Salt of lemery, 99%
|
Biochemical Assay Reagents
|
Others
|
|
Potassium sulfate, 99% (Salt of lemery, 99%) can be used in biochemical tests for serum proteins, the determination of blood potassium and other potassium salts, and the preparation of protein capillary electrophoresis buffers. Potassium sulfate, 99% is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-N4227
-
|
|
Others
|
Cancer
|
|
Conicasterol is a 4-mercaptosteroid with significant cytotoxic activity. Conicasterol showed an IC50 value of 6.23 μg/mL in a test on a human breast adenocarcinoma cell line (MCF-7). Conicasterol's antitumor activity makes it a potential bioactive lead molecule .
|
-
- HY-116245
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Octanophenone is a substance used as a test compound in liquid chromatography research to study related properties such as particle diffusion within the column. A series of experiments showed that the Titan-C18 column in which it is located has some special property differences compared to other columns.
|
-
- HY-116266
-
|
|
5-HT Receptor
|
Others
|
|
RS 67333 is a 5-HT4R agonist with stress-preventive activity. RS 67333 attenuates stress-induced body weight changes and prevents depression- and anxiety-like behaviors in two mouse strains tested in different stress models.
|
-
- HY-N13082
-
|
|
Others
|
Metabolic Disease
|
|
Deacetylescin Ia (compound 12) is a deacetylated compound with anti-hyperglycemic effects that can be extracted from the debittered Aesculus and deacetylated at the C-22 position. Deacetylescin Ia (100 mg/kg) can inhibit blood glucose elevation in mouse glucose tolerance tests .
|
-
- HY-120757
-
|
|
Virus Protease
|
Others
|
|
LP-130 is a statin-based inhibitor that is a universal inhibitor with nanomolar inhibitory activity against all tested retroviral proteases. Crystal structure studies of its binding to different retroviral proteases have shown that it can adapt to different active site regions to achieve inhibition.
|
-
- HY-106752
-
|
MRS-3310
|
Annexin A
|
Neurological Disease
|
|
CI-936 (MRS-3310) is an orally active A2 agonist with 25 nM affinity. CI-936 produces potent and selective effects in preclinical tests predictive of antipsychotic efficacy. CI-936 inhibits exploratory activity in mice .
|
-
- HY-W540861
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3,4-Dichlorophenyl Isothiocyanate is an intermediate in organic synthesis and is used to make other isothiocyanate-containing compounds. 3,4-Dichlorophenyl Isothiocyanate and its derivatives can be used to induce cabbage root flies and test their behavioral responses and trap bait effects .
|
-
- HY-15511
-
|
Tyrphostin 9; Malonoben
|
VEGFR
Influenza Virus
PDGFR
|
Infection
Cancer
|
|
Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.
|
-
- HY-P1746
-
|
PKC (19-31)
|
PKC
|
Inflammation/Immunology
|
|
Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .
|
-
- HY-W775174
-
|
C.I. Solvent red 80
|
Fluorescent Dye
|
|
|
Citrus red 2 (CI Solvent red 80) is a synthetic dye with coloring power and antioxidant activity. Citrus red 2 can be used in food and cosmetics to provide a bright color to the product. Citrus red 2 is also used as a reference substance for testing and analysis in certain situations.
|
-
- HY-114771
-
|
|
Drug Intermediate
|
Inflammation/Immunology
|
|
α-Truxillic acid is form by the dimerization of two molecules of α-trans-cinnamic acid, with anti-inflammatory activities. α-Truxillic acid has no analgesic activity, but its derivatives bound to camphor fragments exhibit significant activity in the peripheral analgesic model (writhing test) .
|
-
- HY-Y1083C
-
|
Salt of lemery, for cell culture
|
Biochemical Assay Reagents
|
Others
|
|
Potassium sulfate, for cell culture (Salt of lemery, for cell culture) can be used in biochemical tests for serum proteins, the determination of blood potassium and other potassium salts, and the preparation of protein capillary electrophoresis buffers. Potassium sulfate, for cell culture is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-P1746A
-
|
PKC (19-31) (TFA)
|
PKC
|
Inflammation/Immunology
|
|
Protein Kinase C (19-31) TFA, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .
|
-
- HY-121256
-
|
|
Thymidylate Synthase
Antifolate
Dihydrofolate reductase (DHFR)
|
Others
|
|
Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents .
|
-
- HY-169737
-
|
|
Glycosidase
Amylases
|
Metabolic Disease
|
|
Inulobiose is a difructan disaccharide that can be isolated from Pistacia vera L.. Inulobiose inhibits α-glycosidase and α-amylase activities with IC50s of 1.87 and 40.72 mg/mL, respectively. Inulobiose can be used for the research of diabetes and glomerular filtration rate testing .
|
-
- HY-N8796
-
|
|
Endogenous Metabolite
|
Cancer
|
|
2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines .
|
-
- HY-168747
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
4-Bromo-2,5-DMMA (Compound 2) has affinity for 5-HT2 binding sites. 4-Bromo-2,5-DMMA has an ED50 of 0.82 mg/kg in the rat discrimination tests .
|
-
- HY-130751
-
DODAP
1 Publications Verification
|
Liposome
|
Inflammation/Immunology
|
|
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
|
-
- HY-10936
-
|
|
iGluR
|
Neurological Disease
|
|
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests .
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-
- HY-123836
-
|
|
Histamine Receptor
|
Neurological Disease
|
|
MK-7288 is a histamine H3 receptor inverse agonist. MK-7288 can prolong sleep latency in the Maintain Wake Test (MWT). MK-7288 can be used in research on obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) .
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-
- HY-D1571
-
|
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DNA Stain
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Others
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|
CellTracker Blue CMF2HC Dye is a blue dye, can be used in two-channel nuclei acid sequencing, with blue and purple excitation light (450-460 nm/400-405nm or 415-450 nm/480-525nm). CellTracker Blue CMF2HC Dye can be used to rapid determination of antibiotic sensitivity of microorganisms .
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-
- HY-P1299A
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
UFP-101 TFA is a potent, selective, and competitive antagonist of the N/OFQ peptide (NOP) receptor, with a pKi of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect .
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-
- HY-D0177
-
|
Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
|
Biochemical Assay Reagents
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Others
|
|
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) is a peptide coupling reagent and BOP analog. (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate promotes the reaction of amino and carboxyl groups to form peptide bonds. (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate can be used in the synthesis of peptide compounds
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-
- HY-P1299
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pKi of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect .
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-
- HY-N11919
-
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Others
|
Cancer
|
|
Anticancer agent 149 (compound 3) is an anticancer agent isolated from the rhizome of Dioscorea dioscorea (DM). Anticancer agent 149 exhibits selective cytotoxic activity against MCF-7 cells (IC50=31.41 μM) .
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-
- HY-105058A
-
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14α/β-RU 24722
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Others
|
Neurological Disease
|
|
14α/β-Vindeburnol (14α/β-RU 24722) a synthetic molecule derived from the eburnamine-vincamine alkaloid group, has many neuropsychopharmacological and antidepressant-like effects .
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-
- HY-N5054
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .
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-
- HY-121804
-
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|
Parasite
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Others
|
|
SSJ-183 is a compound with antimalarial activity, with activity that modulates antimalarial effects and pharmacokinetic properties. SSJ-183 has shown some activity in antimalarial studies, and its pharmacokinetic properties are between those of other tested compounds, which is of certain significance for the study of new antimalarial combination therapies.
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-
- HY-117845
-
|
LL-E19085α
|
Bacterial
Antibiotic
|
Infection
|
|
Citreamicin alpha (LL-E 19085-alpha) is an antibiotic whose in vitro antimicrobial activity against 429 clinical isolates of Gram-positive cocci has been tested by the agar dilution method. These microorganisms included 313 strains of Staphylococci and 116 strains of Streptococci. The in vitro activity of Citreamicin alpha was compared with that of ampicillin, amoxicillin, ceftriaxone, erythromycin, and vancomycin. For Staphylococci, the MIC values of Citreamicin alpha ranged from 0.12-4.0 μg/ml, and for Streptococcus pyogenes of the genus Streptococcus, it was 0.03-0.12 μg/ml. However, enterococci were relatively resistant, requiring 2.0 μg/ml of the agent to inhibit 64% of the 62 tested strains. The in vitro activity of this antibiotic was much better than that of ampicillin, amoxicillin, ceftriaxone, and erythromycin, but comparable or slightly inferior to that of vancomycin.
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-
- HY-N15112
-
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Others
|
Cancer
|
|
Pintulin can inhibit P388, L 1210, HL-60, KB and other tumor cell lines with IC50s (μg/mL) of 0.8, 0.8, 0.8, 0.25, respectively. Pintulin has only very weak antibacterial activity against the microorganisms tested .
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-
- HY-157360
-
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Biochemical Assay Reagents
|
Others
|
|
Acetamide Agar is a solid culture media for non-fermenting bacteria. Acetamide Agar helps differentiate P. acidovorans from other non-sugar-soluble or weakly sugar-soluble Pseudomonas species. Acetamide Agar can be used to test the ability of microorganisms such as Pseudomonas aeruginosa to utilize acetamide through deamination .
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-
- HY-N0446
-
|
|
ADC Payload
|
Cancer
|
|
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .
|
-
- HY-153573
-
|
dCym-JQ1
|
PROTACs
Epigenetic Reader Domain
|
Infection
|
|
SRG-II-19F (dCym-JQ1) is a bromodomain1 of BRDT (BRDTBD1) PROTAC degrader. SRG-II-19F can be used for testing the regulatory effect of ClpC2 on the ClpC1P1P2 protease .
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-
- HY-D0018
-
|
Dichlorophenylindophenol sodium; DCPIP sodium; Indochlorophenol sodium
|
Biochemical Assay Reagents
|
Others
|
|
DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. DCIP sodium has unique chemical properties that change color according to the oxidation state of the substance being tested. It is commonly used in enzyme assays, such as measuring the activity of succinate dehydrogenase, or in protein quantification methods, such as the Lowry assay.
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-
- HY-117963
-
|
|
Antibiotic
|
Infection
|
|
Lincosamine is a lincosamide antibiotic with activity that inhibits bacterial growth. Lincosamine is primarily produced by Streptomyces lincolnensis. Lincosamine has shown efficacy in combating certain bacterial infections, especially against Klebsiella pneumoniae. Lincosamine ranked among 14 other antimicrobial compounds in its activity against Klebsiella pneumoniae in a test .
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-
- HY-122984R
-
|
|
Herbicide
Reference Standards
|
Others
|
|
Diquat (dibromide) (Standard) is the analytical standard of Diquat (dibromide). This product is intended for research and analytical applications. Diquat dibromide is a comprehensive herbicide commonly used in the cultivation of cotton, soybeans, and other crops to combat unwanted weeds. Diquat dibromide has an IC50 of 60 mg/L in the Allium root growth inhibition test .
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-
- HY-18698
-
|
|
iGluR
|
Neurological Disease
|
|
L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity .
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-
- HY-122817
-
|
|
Antibiotic
Parasite
|
Infection
|
|
FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice .
|
-
- HY-W795264
-
|
|
Parasite
|
Infection
|
|
FR900098 is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 has no effect on bone marrow red blood cells in NMRI mice .
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-
- HY-P4466
-
|
|
HIV Protease
|
Infection
|
|
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease. Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 can be used to test HIV-1 protease activity .
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-
- HY-108882C
-
|
|
DNA/RNA Synthesis
|
Others
|
|
DNase I (filtered) (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer . Filtered through a 0.22 μM filter, not tested for pyrogenicity.
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-
- HY-122984S
-
|
|
Isotope-Labeled Compounds
Herbicide
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Others
|
|
Diquat-d4 (dibromide) is the deuterium labeled Diquat dibromide (HY-122984) . Diquat dibromide is a comprehensive herbicide commonly used in the cultivation of cotton, soybeans, and other crops to combat unwanted weeds. Diquat dibromide has an IC50 of 60 mg/L in the Allium root growth inhibition test .
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-
- HY-W087892R
-
|
|
Reference Standards
Biochemical Assay Reagents
|
Others
|
|
Barium diphenylamine-4-sulfonate (Standard) is the analytical standard of Barium diphenylamine-4-sulfonate. This product is intended for research and analytical applications. Barium diphenylamine-4-sulfonate can be employed as an intermediate in pharmaceutical manufacturing and in chemical research, and serves as a dosing agent in analytical testing .
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-
- HY-D0800
-
|
|
Biochemical Assay Reagents
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Others
|
|
Chromeazurol S is a compound belonging to the class of azo dyes. It is often used as an indicator in analytical chemistry to detect metal ions such as copper, nickel, and cobalt. Chromeazurol S turns from yellow to blue in the presence of metal ions, allowing them to be detected and quantified. It can be applied to a test strip or added directly to a solution for analysis.
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-
- HY-N15508
-
|
|
NO Synthase
|
Inflammation/Immunology
|
|
Harzianoside B is a diterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Harzianoside B has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value is close to the maximum tested concentration of 100 µM. It can be used in the research of the anti-inflammatory field .
|
-
- HY-170945
-
|
|
iGluR
Serotonin Transporter
|
Neurological Disease
|
|
Antidepressant agent 9 (Compound 24) is an orally active and BBB-penetrable NMDAR and SERT inhibitor with IC50 values of 3.50 μM and 1044 nM, respectively. Antidepressant agent 9 has good metabolic stability and plasma exposure. Antidepressant agent 9 can exert antidepressant-like activity in the mouse forced swim test .
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-
- HY-W040156R
-
|
|
Fungal
Reference Standards
|
Infection
|
|
Oxadixyl (Standard) is the analytical standard of Oxadixyl. This product is intended for research and analytical applications. Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process .
|
-
- HY-P5296
-
|
|
Fluorescent Dye
|
Others
|
|
Dabsyl-Leu-Gly-Gly-Gly-Ala-Edans is a fluorophore Dabsyl-labeled peptide. Dabsyl-Leu-Gly-Gly-Gly-Ala-Edans can be used to test the peptidase activity of the LasA protease of Pseudomonas aeruginosa. Dabsyl-Leu-Gly-Gly-Gly-Ala-Edans has enzyme specificity and has application value .
|
-
- HY-117831
-
|
|
Bacterial
Antibiotic
Endogenous Metabolite
|
Infection
|
|
NSC-79887 is a nucleoside hydrolase (NH) inhibitor with activity against Bacillus anthracis. NSC-79887 is considered a good candidate inhibitor of nucleoside hydrolases for biological testing and further development. The pharmacokinetic (ADMET) prediction of NSC-79887 showed that all physicochemical parameters were within the acceptable range for human use .
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-
- HY-15904
-
|
ESPA
|
Biochemical Assay Reagents
|
Others
|
|
N-Ethyl-N-(3-sulfopropyl)-m-anisidine sodium (ESPA) is a Trinder's reagent and a highly water-soluble aniline derivative. N-Ethyl-N-(3-sulfopropyl)-m-anisidine sodium has a relatively high absorption wavelength at 540 nm and can be widely used in diagnostic tests and biochemical experiments .
|
-
- HY-147730
-
|
|
HDAC
|
Cancer
|
|
A variety of compounds were designed and synthesized by modifying cap groups. The enzyme inhibition test showed that compound 12C had broad-spectrum enzyme inhibitory activity, and compounds 9m and 9q were more inclined to inhibit HDAC6, showing a certain selective inhibitory activity among the representative subtypes.
|
-
- HY-162572
-
|
|
Parasite
|
Infection
|
|
Bitipazone, diacetylbis(piperidinethyl)thiourea cysteine ester (I), has potent anticoccidial activity. Bitipazone showed significant efficacy and good tolerability in rabbits and turkeys, and in chronic toxicity tests, bitipazone was tolerated in turkeys at concentrations below 90 ppm in feed. Pharmacokinetic studies show that bitipazone is eliminated slowly from the blood and organs of these animal species .
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-
- HY-P0019B
-
|
|
Fluorescent Dye
Thrombin
|
Others
|
|
Z-Gly-Gly-Arg-AMC TFA is the TFA salt form of Z-Gly-Gly-Arg-AMC (HY-P0019). Z-Gly-Gly-Arg-AMC TFA is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
-
- HY-101040R
-
|
Q203 (Standard); IAP6 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Oxadixyl (Standard) is the analytical standard of Oxadixyl. This product is intended for research and analytical applications. Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process .
|
-
- HY-P5486
-
|
|
Bacterial
|
Others
|
|
Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)
|
-
- HY-144289
-
|
|
Glucokinase
|
Metabolic Disease
|
|
BMS-820132 is an orally active and partial glucokinase (GK) activator with a AC50 of 29 nM. BMS-820132 decreases the glucose levels in glucose tolerance test (OGTT) model in normal rats, but not Zucker diabetic fatty (ZDF) rats. BMS-820132 exhibits pharmacological toxicity secondary to strong GK activation .
|
-
- HY-P10203
-
|
|
Opioid Receptor
|
Inflammation/Immunology
|
|
μ/κ/δ opioid receptor agonist 1 is a μ opioid receptor (MOR), κ opioid receptor (KOR), and δ opioid receptor (DOR) agonist. μ/κ/δ opioid receptor agonist 1 produces a strong and long-lasting analgesic effect through peripheral MOR and KOR in the tail-flick test .
|
-
- HY-159088
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
KOR agonist 2 (Compound 23p) is an agonist for κ opioid receptor (KOR) with Ki of 1.9 nM. KOR agonist 2 exhibits analgesic effect in mouse models with ED50 of 1.30 mg/kg. KOR agonist 2 exhibits high clearance rate (2 mg/kg, i.v.) in mice, high metabolism and clearance in liver microsomes .
|
-
- HY-116881
-
|
|
mAChR
|
Neurological Disease
|
|
SCH 57790 is a selective antegonist for muscarinic M2 receptor, which increases acetylcholine release, and thus improves cognitive performance. SCH 57790 reverses Scopolamine (HY-N0296)-induced memory deficits in mice, without significant toxicity (100 mg/kg).
|
-
- HY-111189
-
|
|
GlyT
|
Neurological Disease
|
|
GSK931145 is a glycine transporter 1 (GlyT1) inhibitor with anti-epileptic activity. GSK931145 exhibits a low minimum effective dose in the maximum electrical stimulation threshold test, indicating that it has a significant anti-epileptic effect. GSK931145 is also suitable as a positron emission tomography (PET) radioligand for quantifying the availability of glycine transporters in the living brain .
|
-
- HY-W110794
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Crystal violet, IND (0.0-2.0) is a specialized indicator suitable for strongly acidic systems, which reflects changes in pH within the range of 0.0-2.0 through color changes. Crystal violet, IND (0.0-2.0) is widely used in acid-base titration, chemical analysis, and industrial testing fields .
|
-
- HY-116062
-
|
|
Monoamine Transporter
Dopamine Transporter
Adrenergic Receptor
|
Others
|
|
JNJ-7925476 (hydrochloride) is a triple monoamine uptake inhibitor with the ability to regulate neurotransmitter levels and antidepressant activity. JNJ-7925476 (hydrochloride) can be rapidly absorbed into the plasma in rats, with a higher concentration in the brain than in plasma. It can induce an increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex, and exhibits antidepressant activity in the mouse tail suspension test.
|
-
- HY-W015780
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
1,4-Dimethoxybenzene is an endogenous metabolite. 1,4-Dimethoxybenzene has an anti-anxiety effect, increasing atherogenic index (AI) levels in rabbits and inducing sedentary behavior. Sedentary behavior may increase blood cholesterol levels and disrupt blood lipids .
1,4-Dimethoxybenzene considers to be not clastogenic in the in vivo micronucleus test .
|
-
- HY-178378
-
|
|
Histone Methyltransferase
GLP Receptor
Reactive Oxygen Species (ROS)
Autophagy
Apoptosis
|
Cancer
|
|
G9a-IN-4 is a G9a inhibitor with high selectivity (IC50 = 32 nM). G9a-IN-4 shows high selectivity against the other tested lysine/arginine methyltransferases. G9a-IN-4 exhibits high enzymatic activity against G9a and more potent antiproliferative effects against all tested cancer cells. G9a-IN-4 significantly suppresses the H3K9me2 level. G9a-IN-4 triggers autophagy by inducing the production of ROS, thus leading to cell apoptosis and cell cycle arrest at G0/G1 in CT26 colon cells. G9a-IN-4 can be used for the study of colon cancer .
|
-
- HY-142957
-
|
|
Sodium Channel
Sodium Phosphate Cotransporter
|
Others
|
|
NaPi2b-IN-1 is a potent and orally active inhibitor of sodium-dependent phosphate transport protein 2b (NaPi2b) with an IC50 of 64 nM. NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. NaPi2b-IN-1 has the potential for the research of hyperphosphatemia .
|
-
- HY-119530
-
|
BW 57-323
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.
|
-
- HY-B1146R
-
|
THS-839 (Standard)
|
Insecticide
Reference Standards
|
Others
|
|
Denatonium (benzoate) (Standard) is the analytical standard of Denatonium (benzoate). This product is intended for research and analytical applications. Denatonium benzoate (THS-839) is the most bitter compound known, commonly used as an aversion agent (bitter agent) to prevent inappropriate ingestion, used in denatured alcohol, antifreeze, nail biting prevention, respirator mask fit testing , animal repellents, liquid soaps and shampoos.
|
-
- HY-160043
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
AL6 aptamer sodium is a short-chain nucleic acid aptamer chemically synthesized in vitro. AL6 aptamer sodium specifically targets Angiopoietin (Ang) for the specific detection of Ang. The AL6 aptamer binds to Ang, causing the rotational motion of the fluorophore on the AL6 aptamer to become slower. The concentration of Ang in the test solution can be quantified by detecting the anisotropy of AL6 aptamer/Ang .
|
-
- HY-D0945
-
|
|
Fluorescent Dye
|
Others
|
|
Xylene Cyanol FF is an acid triphenylmethane dye. Xylene Cyanol FF can be used for histochemical staining of hemoglobin peroxidase or as a tracking dye for DNA sequencing in electrophoresis. Xylene Cyanol FF will be catalyzed by Fe and Al to accelerate oxidation under the addition of double oxidant hydrogen peroxide and potassium periodate. Xylene Cyanol FF thus enables the spectrophotometric determination of Fe and Al in the solution to be tested .
|
-
- HY-E70412
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
Galactose 1-dehydrogenase, E.coli is a dehydrogenase expressed in E. coli. Galactose 1-dehydrogenase, E.coli catalyzes the oxidation of L-arabinose and D-galactose using NADP +/NAD + as cofactors. Galactose 1-dehydrogenase, E.coli can be used in diagnostic tests to determine total galactose content and can also serve as a biocatalyst for producing galacturonate .
|
-
- HY-15511R
-
|
|
VEGFR
Influenza Virus
PDGFR
|
Infection
Cancer
|
|
Tyrphostin A9 (Standard) is the analytical standard of Tyrphostin A9. This product is intended for research and analytical applications. Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.
|
-
- HY-111066
-
|
|
Dopamine Receptor
|
Others
|
|
JNJ-37822681 is a fast dissociating D2 antagonist with activity in inhibiting schizophrenia. JNJ-37822681 has high specificity for D2 receptors and is effective in animal models, inducing increased levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex, and exhibiting antidepressant activity in the mouse tail suspension test, while having a good brain distribution and lower prolactin release.
|
-
- HY-13643
-
|
|
Histone Demethylase
|
Cancer
|
|
Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested .
|
-
- HY-147786
-
|
|
TGF-β Receptor
|
Cancer
|
|
TGFβRI-IN-5 (Compound 4b) is a potent inhibitor of TGFβRI with an IC50 of 0.08 μM. TGFβRI-IN-5 displays amazing anticancer activity 5–7 times that of reference agent against all the tested cell lines. TGFβRI-IN-5 enhances apoptosis and arrested G2/M phase of cell cycle .
|
-
- HY-N6771
-
|
|
Calcium Channel
5-HT Receptor
MDM-2/p53
Apoptosis
RSV
|
Infection
|
|
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B [1][4][5].
|
-
- HY-D0018R
-
|
Dichlorophenylindophenol sodium (Standard); DCPIP sodium (Standard); Indochlorophenol sodium (Standard)
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
|
DCIP (sodium) (Standard) is the analytical standard of DCIP (sodium). This product is intended for research and analytical applications. DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. DCIP sodium has unique chemical properties that change color according to the oxidation state of the substance being tested. It is commonly used in enzyme assays, such as measuring the activity of succinate dehydrogenase, or in protein quantification methods, such as the Lowry assay.
|
-
- HY-E70412A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
Galactose 1-dehydrogenase, pseudomonas fluorescens is a dehydrogenase expressed in Pseudomonas fluorescens. Galactose 1-dehydrogenase, pseudomonas fluorescens catalyzes the oxidation of L-arabinose and D-galactose using NADP +/NAD + as a cofactor. Galactose 1-dehydrogenase, pseudomonas fluorescens can be used in diagnostic tests to measure total galactose content and can also act as a biocatalyst for producing galacturonic acid salts .
|
-
- HY-126224
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Driselase, Basidiomycetes sp, a complex mixt. of wall-digesting enzymes, is a specific commercial fungal protoplasting enzyme preparation. Driselase can be used in combination with lyase to promote protoplast formation in fungi. Driselase is by far the most potent of the enzymes tested for polysaccharide digestion and greatly increases both tensile and indentation compliances, yet it does not induce wall creep, even after 6 h of digestion .
|
-
- HY-119513
-
|
|
Others
|
Neurological Disease
|
|
Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke .
|
-
- HY-10886
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
MCOPPB is an orally active and selective agonist of Nociceptin/Orphanin FQ–Receptor. MCOPPB inhibits signaling through the NOP receptor in the mouse brain. MCOPPB is used in anxiety disorders research .
|
-
- HY-16745A
-
|
KRP-AM1977 hydrochloride
|
Bacterial
|
Infection
|
|
Lascufloxacin (KRP-AM1977) hydrochloride is a potent antibacterial compound candidate with broad-spectrum activity against various clinical isolates. Lascufloxacin hydrochloride shows the most potent activity against Gram-positive bacteria compared to other tested quinolones. Lascufloxacin hydrochloride demonstrates incomplete cross-resistance against existing quinolone-resistant strains. Lascufloxacin hydrochloride has potent inhibitory activity against both wild-type and mutated target enzymes.
|
-
- HY-100679B
-
|
|
Monoamine Oxidase
|
Neurological Disease
|
|
(R)-Pirlindole mesylate is selective and reversible a Monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.43 μM for MAO-A over MAO-B. (R)-Pirlindole mesylate has an antidepressant activity. (R)-Pirlindole mesylate significantly decreases immobility time of the forced swim test and inhibits Reserpine (HY-N0480)-induced palpebral ptosis in behavioural mice models. (R)-Pirlindole mesylate can be used for depression research .
|
-
- HY-19752
-
|
CID-25010775 free base
|
mAChR
|
Neurological Disease
|
|
VU0357017 (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 can be used for the research of Alzheimer’s disease and schizophrenia .
|
-
- HY-19752A
-
|
CID-25010775
|
mAChR
|
Neurological Disease
|
|
VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 hydrochloride is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia .
|
-
- HY-N0446R
-
|
|
ADC Payload
Reference Standards
|
Cancer
|
|
10-Methoxycamptothecin (Standard) is the analytical standard of 10-Methoxycamptothecin. This product is intended for research and analytical applications. 10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .
|
-
- HY-162757
-
|
|
GABA Receptor
Sodium Channel
|
Neurological Disease
|
|
Anticonvulsant agent 5 (Compound 5c) exhibits high affinity for GABAA receptors and NaV1.3 receptors. Anticonvulsant agent 5 shows anticonvulsant efficacy in mice psychomotor epilepsy test with an ED50 of 107 mg/kg. Anticonvulsant agent 5 exhibits neuroprotective activity against Kainic acid (HY-N2309) with an IC50 of 113 μM. Anticonvulsant agent 5 is blood-brain barrier (BBB) penetrable .
|
-
- HY-131335
-
|
|
p38 MAPK
|
Inflammation/Immunology
|
|
p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets .
|
-
- HY-126230A
-
|
|
Endogenous Metabolite
|
Cancer
|
|
(Rac)-PAT-494 is a type II autotaxin inhibitor with the activity of inhibiting the production of lysophosphatidic acid (LPA) in the blood. (Rac)-PAT-494 can participate in the inhibition of diseases related to cancer, fibrosis and inflammation by antagonizing the function of autotaxin. (Rac)-PAT-494 shows high activity in biochemical and plasma tests. (Rac)-PAT-494 can reduce plasma LPA levels after oral administration to rats .
|
-
- HY-131328
-
|
LOXO-305
|
Btk
|
Cancer
|
|
Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM .
|
-
- HY-169335
-
|
|
HIV
|
Infection
|
|
HIV-1 inhibitor-77 (compound 13) is a HIV-1 inhibitor. HIV-1 inhibitor-77 can neutralize all three tested viruses with the IC50 values of 0.14 μM, 8.28 μM and 2.92 μM for HIV-1CH58TF , HIV-1 JRFL and HIV-1 AD8, respectively .
|
-
- HY-135599
-
|
|
Bacterial
|
Infection
|
|
Lysine hydroxamate is an amino acid hydroxamate that inhibits the growth of Escherichia coli K-12. Of the other amino acid hydroxamates tested, only L-lysine hydroxamate reduced the growth rate. The inhibition of growth by L-serine hydroxamate could be rapidly reversed by adding L-serine to the bacterial culture or by removing the analog by filtration. This reversal was specific for L-serine. L-alanine, glycine, or adenine had no effect on the inhibited culture. There was no evidence for active transport of the analog.
|
-
- HY-114362
-
|
TPGS-750-M
|
Biochemical Assay Reagents
|
Others
|
|
DL-alpha-Tocopherol methoxypolyethylene glycol succinate (TPGS-750-M) is an amphiphile, acts as a surfactant. DL-alpha-Tocopherol methoxypolyethylene glycol succinate has a positive effect on Suzuki-Miyaura cross coupling. DL-alpha-Tocopherol methoxypolyethylene glycol succinate increases the styrene titer. DL-alpha-Tocopherol methoxypolyethylene glycol succinate is used in the stability test of NPYM-modified drugs in biological fluids .
|
-
- HY-N8852
-
|
6-MeOF
|
GABA Receptor
Taste Receptor
|
Neurological Disease
Metabolic Disease
|
|
6-Methoxyflavanone (6-MeOF) is a flavonoid compound that can cross the blood-brain barrier. 6-Methoxyflavanone is a positive allosteric modulator of GABAA receptors. 6-Methoxyflavanone exhibits positive allosteric regulatory effects on human recombinant α1β2γ2L and α2β2γ2L GABAA receptors, and is relatively inactive on the α1β2 GABAA receptor. 6-Methoxyflavanone showes inhibitory behavior towards the activation of bitter receptor hTAS2R39 and hTAS2R14, demonstrating a reversible and non-overcome antagonistic effect. 6-Methoxyflavanone has the effects of anti-anxiety, analgesia and relief of neuropathic pain .
|
-
- HY-A0096A
-
|
(Z)-Ciloprost; (Z)-ZK 36374
|
Others
|
Cardiovascular Disease
|
|
(Z)-Iloprost ((Z)-Ciloprost; (Z)-ZK 36374) is a vasodilator that prevents heparin-induced platelet activation .
|
-
- HY-107565
-
|
|
Histamine Receptor
|
Inflammation/Immunology
|
|
2-Pyridylethylamine is a histamine-1 (H1R) receptor agonist. 2-Pyridylethylamine can reduce the joint injury induced by formalin in rats. 2-Pyridylethylamine can be used to study the spinal cord release of neuropeptide (NPY) .
|
-
- HY-158261
-
|
|
Cholinesterase (ChE)
Amyloid-β
Beta-secretase
|
Neurological Disease
|
|
AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research .
|
-
- HY-116945
-
|
|
Endogenous Metabolite
|
Others
|
|
Diphenamid is a chemical compound that exhibits herbicide activity. Diphenamid acts by inhibiting the enzyme acetyl-CoA carboxylase. Diphenamid has shown resistance as a model for mimicking organic pollutants in wastewater treatment processes, especially in the presence of multiple anions. The degradation of diphenamid is significantly affected by certain inorganic ions, such as chromium (VI) and nitrogen oxides. Diphenamid shows changes in toxicity with longer treatment times, and the results of toxicity tests on selected algae indicate higher toxicity at 240 minutes of treatment .
|
-
- HY-126596
-
|
|
Apoptosis
|
Cancer
|
|
Angelylalkannin is a naphthoquinone compound isolated from the root of Alkanna tinctoria. Angelylalkannin showed significant inhibitory effects in the antiproliferative effect test on human colon cancer cells HCT-116 and SW-480. The median inhibitory concentration (IC50) of Angelylalkannin was 4.76 mM for HCT-116 cells and 7.03 mM for SW-480 cells. Like alkannin, Angelylalkannin can arrest the cell cycle in the G1 phase and induce apoptosis at a concentration of 1-10 mM.
|
-
- HY-N10653
-
|
(-)-Altemicidin
|
Others
|
Cancer
|
|
Altemicidin is a monoterpene alkaloid originally isolated from S. sioyaensis with acaricidal and anticancer activities. It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s=0.84 and 0.82 μg/mL, respectively). It is toxic to mice with an LD50 value of 0.3 mg/kg.
|
-
- HY-119821R
-
|
|
Reference Standards
Glycosidase
|
Infection
|
|
Thiamiprine (Standard) is the analytical standard of Thiamiprine. This product is intended for research and analytical applications. Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.
|
-
- HY-170688
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibacterial agent 119 (Compound 21 g) is an antibacterial candidate against Methicillin (HY-121544)-resistant Staphylococcus aureus (MICs less than 1 μg/mL against tested strains). Antibacterial agent 119 induces ROS production. Antibacterial agent 119 also acts on the bacterial cell membrane to cause membrane breakage. Antibacterial agent 119 exhibits potent antibacterial activity with low cytotoxicity, rapid bactericidal ability, and good in vivo antibacterial activity .
|
-
- HY-135495
-
|
|
Sodium Channel
Histamine Receptor
|
Inflammation/Immunology
|
|
AM-0466 is a sodium channel inhibitor with nanomolar levels of NaV1.7 inhibitory activity. AM-0466 exhibits potent pharmacodynamic activity in a NaV1.7-dependent histamine-induced itch model. AM-0466 also showed significant analgesic effects in capsaicin-induced pain models. After optimizing its pharmacokinetic properties, AM-0466 was advanced into in vivo targeting and efficacy models for testing .
|
-
- HY-111311
-
|
|
Bacterial
Drug Derivative
|
Infection
|
|
NVC-422 is a N-chlorotaurine analog, virucidal agent, antibacterial agent. NVC-422 exhibits virucidal activity against Ad5 by the oxidative inactivation of key viral proteins (fiber and hexon), leading to the loss of viral integrity and infectivity. NVC-422 is shown to be highly effective in killing all microbial strains tested, including antibiotic-resistant S. aureus and E. faecium. NVC-422 can be used in the research of adenoviral conjunctivitis .
|
-
- HY-D0007
-
|
Tetrazolium blue
|
Fluorescent Dye
|
Others
|
|
Blue Tetrazolium (Tetrazolium blue), as a blue dye for microbial research, can be reduced into blue tetrazolium formazan (BTF). Blue Tetrazolium can be used to determine the activity of succinate dehydrogenase (SDH) in yeast strains, which has been reduced as a substrate. Use DMSO to extract BTF from cells, and test absorption spectrum of BTF. The BTF shows a wide wavelength range of 480-600 nm with maximal absorbance seen at 540 nm. Blue Tetrazolium, combines with succinate dehydrogenase (SDH) .
|
-
- HY-118077
-
|
|
Others
|
Others
|
|
RE 11775 (m-tert-butylphenyl-N-methyl-N-(phenylthio) carbonate) is a new carbonate ester with unusually high toxicity to mosquito larvae. Laboratory and field evaluations have shown that it has potential for use in controlling sensitive and organophosphate-resistant larval and adult stages of Aedes nigromaculis (Ludlow). Preliminary studies also suggest that RE 11775 may also be useful for controlling sensitive and organophosphate-resistant Culex spccies. This new carbonate ester is relatively safe, with no adverse effects found in current testing.
|
-
- HY-119530R
-
|
BW 57-323 (Standard)
|
Nucleoside Antimetabolite/Analog
Reference Standards
|
Others
|
|
Thiamiprine (Standard) is the analytical standard of Thiamiprine. This product is intended for research and analytical applications. Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.
|
-
- HY-W115718R
-
|
|
Dopamine β-hydroxylase
|
Neurological Disease
|
|
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .
|
-
- HY-W115718
-
|
|
Dopamine β-hydroxylase
|
Neurological Disease
|
|
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .
|
-
- HY-13643R
-
|
|
Reference Standards
Histone Demethylase
|
Cancer
|
|
Daminozide (Standard) is the analytical standard of Daminozide. This product is intended for research and analytical applications. Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested .
|
-
- HY-D0228
-
|
Azo Violet; Magneson I
|
Fluorescent Dye
|
Others
|
|
4-(4-Nitrophenylazo)resorcinol is an azo purple dye used experimentally as a pH indicator, showing yellow when the pH value is lower than 11 and purple when the pH value is higher than 13. In slightly alkaline or alkaline environments, it also turns dark blue in the presence of magnesium salts. Azo Violet can also be used to test for the presence of ammonium ions. The color of the ammonium chloride or ammonium hydroxide solution will change depending on the concentration of azo violet used.
|
-
- HY-13509
-
|
|
RGS Protein
|
Inflammation/Immunology
|
|
CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site . CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test .
|
-
- HY-107910
-
|
Hyaluronate 4-glycanohydrolase, Bovine testes; Hyaluronoglucosaminidase, Bovine testes
|
NF-κB
|
Inflammation/Immunology
Cancer
|
|
Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection .
|
-
- HY-N3017
-
|
|
Antibiotic
|
Neurological Disease
Inflammation/Immunology
|
|
Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED50 of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED50 of 1.6 μg/kg, and has analgesic activity .
|
-
- HY-W391625
-
|
(Rac)-Epiligulyl oxide
|
Fungal
|
Cancer
|
|
(Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .
|
-
- HY-19377
-
|
|
Fungal
Cytochrome P450
|
Infection
|
|
SS-750 is an orally active Triazole derivative and antifungal agent. SS-750 binds to fungal cytochrome P450. SS-750 shows antifungal activities against Candida species and C. neoformans strains tested. SS750 shows MIC90 values of 0.25, 1, and 2 μg/mL against Candida parapsilosis, C. krusei, and C. glabrata, respectively. SS-750 improves systemic and pulmonary candidiasis caused by C. albicans .
|
-
- HY-15257
-
|
AFQ056
|
mGluR
|
Neurological Disease
|
|
Mavoglurant (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant can be used for the research of Fragile X syndrome (FXS), and L-dopa induced dyskinesias in Parkinson's disease . Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-129836
-
|
|
Antibiotic
|
Infection
|
|
L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .
|
-
- HY-106761
-
|
|
Calcium Channel
|
Cardiovascular Disease
Others
|
|
Oxodipine, a dihydropyridine-type calcium antagonist, inhibits KCl-induced aortic contraction in rabbits and reduces cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduces L-type Ca currents (I) with an IC50 of 0.24 μM, and against T-type Ca currents (I) with an IC50 of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs .
|
-
- HY-125928
-
|
|
Sodium Channel
|
Neurological Disease
|
|
AA43279 is an in gamma-aminobutyric acid (GABA) fast-firing interneurons located activator for Nav1.1 channel (SCN1A) with an EC50 of 9.5 μM. AA43279 enhances specific neuronal firing activity in vitro, and exhibits anticonvulsant activity in rat MEST model .
|
-
- HY-N11997
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Feralolide is a dihydroisocoumarin isolated from the methanolic extract of aloe vera resin. Feralolide is also a dual inhibitor of AChE and BuChE, with IC50s of 55 μg/mL and 52 μg/mL respectively. Feralolide has antioxidant activity and inhibits 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Feralolide could be used in research into cognitive disorders such as Alzheimer's disease, potentially restoring and enhancing memory .
|
-
- HY-N15309
-
|
Torvoside K
|
Fungal
|
Infection
|
|
Torvoside C (Torvoside K) is a compound found in Solanum torvum with antifungal activity. The ZOIs and MIC values of Torvoside C against the tested fungi (Alternaria brassicicola, Alternaria geophila, Aspergillus flavus, etc.) range from 33.4% to 87.4% and 31.25 to 250 μg/mL, respectively. Additionally, it exhibits a dose-dependent inhibitory effect on the production of mycotoxins aflatoxin B1 and fumonisin B1, which are produced by A. flavus and F. verticillioides, respectively. Torvoside C can be used for research in the field of antifungal infection .
|
-
- HY-129207
-
|
|
GHSR
|
Endocrinology
|
|
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 μg/kg.
|
-
- HY-N3887
-
|
Haplophytin B; Haplophytine B
|
Bacterial
|
Infection
|
|
Evoxine (Haplophytin B) is a compound that selectively inhibits CO2-induced immunosuppression and has activity in inhibiting the expression of interleukin-6 and chemokine CCL2 in human THP-1 macrophages. Evoxine shows antimicrobial activity against a wide range of bacteria, especially performing well in minimum inhibitory concentration (MIC) tests against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. Evoxine extracts may find application in crude drug preparations in West Africa, provided that their in vivo toxicity results are negative .
|
-
- HY-177497
-
|
|
Histone Methyltransferase
Apoptosis
|
Cancer
|
|
SKLB-03220 is a selective and orally active EZH2 covalent inhibitor with an IC50 of 1.72 nM for EZH2 MUT. SKLB-03220 exhibits weak activities against other tested histone methyltransferases (HMTs) and kinases. SKLB-03220 displays noteworthy potency against ovarian cancer cell lines and induces cell apoptosis. SKLB-03220 significantly inhibits tumor growth in PA-1 xenograft model. SKLB-03220 can be used for the study of ovarian cancer .
|
-
- HY-149270
-
|
|
COX
|
Inflammation/Immunology
|
|
COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). COX-2-IN-31 also inhibits transmembrane hCA IX(Ki=48.9 nM) and hCA XII(Ki=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity .
|
-
- HY-W003222
-
|
|
Drug Intermediate
|
Metabolic Disease
|
|
N-tert-Boc-cis-4-fluoro-L-proline (Compound 11) is a drug intermediate for the synthesis of 4-fluoropyrrolidine-2-carbonitrile DPP-4 inhibitor. N-tert-Boc-cis-4-fluoro-L-proline can be used to study type 2 diabetes .
|
-
- HY-131146
-
|
3-Amino-5-morpholinomethyl-2-oxazolidone
|
Antibiotic
|
Infection
|
|
AMOZ is a carcinogenic metabolite of Furaltadone (HY-B1148A), which forms stable tissue residues by covalently binding to proteins as a hapten. AMOZ can be coupled with carrier proteins (such as BSA/OVA) to induce immune response and is released after acid hydrolysis. AMOZ residues can be detected by competitive ELISA method, and the detection limit in the monoclonal antibody 2E5.1 test is as low as 0.16 μg/kg (shrimp sample). AMOZ can be used as a typical marker to monitor drug residues in animal-derived foods in the field of food safety[1][2].
|
-
- HY-163345
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment .
|
-
- HY-155529
-
|
|
Pim
|
Cancer
|
|
FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice .
|
-
- HY-P0165B
-
|
ITM077 acetate; R1583 acetate; BIM51077 acetate
|
GLP Receptor
|
Metabolic Disease
|
|
Taspoglutide (R1583) acetate is an agonist of the glucagon-like peptide 1 receptor (GLP-1R) with an Ki value of 1.1 nM. Taspoglutide acetate induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). Taspoglutide acetate decreases blood levels of glucose and increases blood levels of insulin in a glucose tolerance test in Zucker diabetic obese rats. Taspoglutide acetate reduces blood levels of gastric inhibitory polypeptide (GIP), plasma levels of triglycerides, and body weight in the same model .
|
-
- HY-D0970
-
|
Direct Blue 14; Trypan Blue
|
Fluorescent Dye
|
Others
|
|
Diphenyl Blue (Trypan Blue) is a cell active dye, the most commonly used dye for the identification of dead cells, of en used to test cell membrane integrity and cell viability. Diphenyl Blue staining is one of the methods for tissue and cell culture. When cells are deactivated or have incomplete cell membranes, Diphenyl Blue can stain them Blue. Normal living cells with intact cell membranes reject Diphenyl blue and do not stain them blue. However, macrophages are capable of phagocytosis of Diphenyl Blue, so it can be used as a living stain for macrophages .
|
-
- HY-158230
-
|
|
Topoisomerase
|
Cancer
|
|
SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells .
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-
- HY-13509R
-
|
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RGS Protein
|
Inflammation/Immunology
|
|
CCG-50014 (Standard) is the analytical standard of CCG-50014. This product is intended for research and analytical applications. CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site . CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test .
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- HY-113703
-
|
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Antibiotic
|
Cancer
|
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PD117588 is a quinolone antibacterial agent with a broad range of antibacterial activity. PD117588 exhibits excellent activity against a variety of Gram-positive and Gram-negative bacteria from cancer patients, especially against all Gram-positive strains, including methicillin-resistant Staphylococcus aureus, coagulase-negative Staphylococci, and Enterococci. PD117588 is also very effective against most Gram-negative bacilli, although ciprofloxacin shows stronger activity against Pseudomonas aeruginosa. Compared with other quinolone antibiotics, the minimum inhibitory concentration of PD117588 outperforms most of the tested microorganisms, including imipenem and ceftazidime .
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- HY-W015786R
-
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Reference Standards
Bacterial
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Infection
Metabolic Disease
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|
L-Amoxicillin (Standard) is the analytical standard of L-Amoxicillin. This product is intended for research and analytical applications. L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .
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-
- HY-W743258
-
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Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Others
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|
L-Amoxicillin-d4 sodium is the deuterium labeled L-Amoxicillin (HY-129836). L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .
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-
- HY-121634
-
|
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Polo-like Kinase (PLK)
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Others
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|
DAP-81 is an inhibitory agent targeting Polo-like kinases (Plks), a class of evolutionarily conserved serine/threonine kinases. DAP-81 dose-dependently increases the number of monopolar spindles in treated cells. High-resolution live-cell microscopy revealed that Plk activity is required for the assembly and maintenance of bipolar mitotic spindles. Plk inhibition destabilizes centromeric microtubules while stabilizing other spindle microtubules, leading to the formation of monopolar spindles. Further testing of compounds based on "privileged scaffolds" such as the DAP scaffold may lead to the discovery of new cell division probes and anti-microtubule agents.
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-
- HY-175701
-
|
RO7795081; RG6652
|
GLP Receptor
Arrestin
|
Metabolic Disease
|
|
CT-996 is an orally active GLP-1RA agonist, with an EC50 of 0.49 nM. CT-996 reduces the β-arrestin recruitment and GLP-1R internalization. CT-996 suppresses postprandial blood glucose following a mixed meal tolerance test (MMTT) in mice expressing the human GLP-1 receptor and enhances glucose stimulated insulin secretion (GSIS) during an intravenous glucose challenge in obese monkeys. CT-996 can be used for the study of type 2 diabetes (T2D) and obesity .
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-
- HY-W714137
-
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Lesquerellin; 6-Methylthiohexyl isothiocyanate
|
Bacterial
|
Infection
|
|
(6-Isothiocyanatohexyl)(methyl)sulfane (Lesquerellin; 6-Methylthiohexyl isothiocyanate) is an isothiocyanate found in wasabi (W. japonica) and has various biological activities. (6-Isothiocyanatohexyl)(methyl)sulfane is active against the bacterium Bacillus subtilis and the fungus T. mentagrophytes (MIC=25 μg/mL). (6-Isothiocyanatohexyl)(methyl)sulfane also has anthelmintic activity against blue mussel (M. edulis). (6-Isothiocyanatohexyl)(methyl)sulfane has antifouling activity when applied to polyvinyl chloride (PVC) panels at a concentration of 50 μmol/cm2 in a conventional immersion test.
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-
- HY-15257R
-
|
|
mGluR
|
Neurological Disease
|
|
Mavoglurant (Standard) is the analytical standard of Mavoglurant. This product is intended for research and analytical applications. Mavoglurant (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant can be used for the research of Fragile X syndrome (FXS), and L-dopa induced dyskinesias in Parkinson's disease . Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-129836R
-
|
|
Antibiotic
Reference Standards
|
Infection
|
|
L-Amoxicillin (Standard) is the analytical standard of L-Amoxicillin. This product is intended for research and analytical applications. L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .
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-
- HY-175637
-
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COX
MyD88
|
Neurological Disease
Inflammation/Immunology
|
|
COX-2-IN-57 is an orally active COX-2 inhibitor with an IC50 value of 0.02 μM. COX-2-IN-57 reduces MyD88 expression and decreases serum levels of COX-2, PGE2, and COX-1 in Cisplatin (HY-17394)/radiation-induced neuropathy rat model. COX-2-IN-57 demonstrates superior antinociceptive efficacy in hot plate, cold allodynia, and Randall-Selitto tests, along with hepato-/renal protection. COX-2-IN-57 can be used for the study of inflammation .
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-
- HY-W052508R
-
|
N-Desalkylquetiapine (Standard)
|
5-HT Receptor
|
Neurological Disease
|
|
Norquetiapine is an antidepressant and neuroprotective agent and is the active metabolic component of Quetiapine (HY-14544). Norquetiapine is also a partial 5-HT1A receptor agonist, and a presynaptic α2, 5-HT2C and 5-HT7 b> Receptor antagonist. Norquetiapine can also selectively inhibit norepinephrine transporter (NET), inhibit norepinephrine reuptake, and has potential inhibitory effects on bipolar depression, major depressive disorder, and generalized anxiety disorder. Norquetiapine demonstrated in vivo activity in forced swimming in mice and learned helplessness tests in rats .
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-
- HY-P1441A
-
|
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Sodium Channel
|
Neurological Disease
|
|
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.
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-
- HY-19369
-
|
L-685,458
|
γ-secretase
Apoptosis
|
Neurological Disease
Cancer
|
|
L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers .
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-
- HY-122204
-
|
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HIV
|
Infection
|
|
5M038 is an inhibitor of HIV envelope-mediated fusion with potent inhibitory activity against gp41-mediated membrane fusion. 5M038 prevents the formation of the gp41 post-fusion conformation and inhibits envelope-mediated membrane fusion in cell-cell fusion and viral infectivity assays. 5M038 has shown broad fusion inhibition in tests against multiple HIV-1 subtypes, including M and T strains. 5M038 targets a highly conserved hydrophobic pocket and binds to the gp41 trimer, thereby exerting its inhibitory effect .
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- HY-146201
-
|
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Phosphodiesterase (PDE)
5-HT Receptor
|
Neurological Disease
|
|
PDE4B/7A-IN-1 (compound 7) is a PDE4B/PDE7A inhibitor (PDE4B, IC50=80.4 μM) and 5-HT1A/5-HT-7R antagonist. PDE4B/7A-IN-1 has membrane-penetrating activity and high metabolic stability. PDE4B/7A-IN-1 exhibits antidepressant properties in rat behavioral tests .
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- HY-122189
-
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(-)-Akuammine; Vincamajoridine
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Others
|
Neurological Disease
|
|
Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.
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-
- HY-125172
-
|
Polyglutamine Aggregation inhibitor III
|
Huntingtin
|
Others
|
|
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
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- HY-18332B
-
|
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Dopamine Transporter
Adrenergic Receptor
5-HT Receptor
|
Neurological Disease
|
|
DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC50 = 129 nM; Ki = 222 nM), norepinephrine (NET) (IC50 = 103 nM; Ki = 1030 nM), and serotonin (SERT) (IC50 = 133 nM; Ki = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression .
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- HY-N8487
-
|
|
Cytochrome P450
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
7-Methoxyflavone is a flavonoid compound that can be isolated from Zornia brasiliensis. 7-Methoxyflavone can bind to human serum albumin and is an aromatase inhibitor. 7-Methoxyflavone has peripheral analgesic and certain antitumor activities. 7-Methoxyflavone is effective against chemical pain but has no significant effect on thermal pain .
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-
- HY-E70398
-
|
L-Iditol dehydrogenase; Polyol dehydrogenase; SDH
|
Biochemical Assay Reagents
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Others
|
|
Sorbitol dehydrogenase is an oxidoreductase. Sorbitol dehydrogenase can be used as a marker for drug-induced liver injury .
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- HY-15007
-
|
|
Oxytocin Receptor
|
Endocrinology
|
|
L 366509 is a spiroindenylpiperidine camphorsulfonamide oxytocin (OT) antagonist. Modifications led to a new series of o-tolylpiperazine (TP) camphorsulfonamides, exhibiting high affinity for OT receptors and selectivity over arginine vasopressin receptors. Notably, compound 7 (L-368,899) showed excellent OT receptor affinity, potency in inhibiting OT-stimulated uterine contractions, good aqueous solubility, and oral bioavailability in multiple species. Compound 7 has entered clinical testing as an oral and intravenous tocolytic agent. Molecular modeling suggests the TP camphorsulfonamide structure mimics the D-AA2-Ile3 dipeptide, crucial in potent OT antagonists .
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-
- HY-10672
-
|
|
Urotensin Receptor
Cytochrome P450
Sodium Channel
Opioid Receptor
|
Cardiovascular Disease
|
|
Urotensin-II receptor antagonist-1 (compound 1) is a low oral bioavailability (F=0-3%, rat) selective human Urotensin II receptor antagonist, Ki=16 nM (test on HEK293 cells expressing recombinant human UT receptor). Urotensin-II receptor antagonist-1 inhibits cytochrome P450 (IC50=0.75 μM, CYP2D6; 1.4 μM, CYP3A4), inhibits κ-opioid receptor (EC50=3.2 μM), targets cardiac sodium channels (Ki=2.5 μM) .
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-
- HY-15929
-
TBHBA
1 Publications Verification
2,4,6-Tribromo-3-hydroxybenzoic acid
|
Biochemical Assay Reagents
|
Others
|
|
TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a chemical colorimetric agent and nanomaterial surface modifier. TBHBA can react with some oxidants (such as H2O2) to generate high-absorbance quinoneimine dyes, which enhance the sensitivity of HDL cholesterol enzymatic determination. TBHBA can be used as a bromine-containing coupling agent to modify the surface of silica nanoparticles through esterification reaction. Thereby, organic flame retardant groups are introduced to improve the thermal stability and flame retardant properties of nanocomposites. TBHBA can be used in clinical biochemical testing (such as serum lipoprotein analysis) and the preparation of flame-retardant polymer nanocomposites .
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-
- HY-W540232
-
|
4-Methylphenyl ITC
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
4-Methoxyphenyl isothiocyanate (4-Methylphenyl ITC) is an antioxidant, with a IC50 value of 1.25 mM for scavenging DPPH radicals. ORAC testing indicates its antioxidant capacity as 11.7 mM TE (indicating that the antioxidant efficacy of this compound is equivalent to 11.7 mmol of Trolox (HY-101445, a standard antioxidant) under the same conditions), and it extends the oxidation process by approximately 9180 seconds in the Briggs–Rauscher reaction. Additionally, 4-Methoxyphenyl isothiocyanate exhibits moderate cholinesterase inhibitory activity, with an inhibition rate of 30.4% against acetylcholinesterase (AChE) and 17.9% against butyrylcholinesterase (BChE). 4-Methoxyphenyl isothiocyanate holds potential for research in the fields of antioxidation and neurological disorders .
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-
- HY-117881
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
CJ-15208 is a potent and selective κ-opioid receptor antagonist with significant opioid activity. CJ-15208 exhibited strong analgesic effects in the warm water tail withdrawal test in mice and was mediated through multiple opioid receptors. The stereoisomers of CJ-15208 exhibited different opioid activity characteristics, for example, one stereoisomer exhibited κ-opioid receptor antagonism, while the other exhibited δ-opioid receptor antagonism. All stereoisomers of CJ-15208 had no significant effects on respiration. The stereoisomers of CJ-15208 did not lead to the development of drug tolerance, which makes it potential in the further development of safe opioid analgesics .
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-
- HY-145858
-
|
|
Ferroptosis
|
Cancer
|
|
Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD .
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-
- HY-Y0678
-
|
TRIMETHYL PHLOROGLUCINOL
|
Others
|
Others
|
|
1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl +) and free bromine (Br +). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
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-
- HY-19873
-
|
|
Photosensitizer
|
Cancer
|
|
SL-052 is a hypocrellin-based photosensitizer that has recently shown promising results in clinical and preclinical testing for cancer photodynamic therapy (PDT). SL-052 is encapsulated in biodegradable polylactic-co-glycolic acid (PLGA) polymer nanoparticles optimized using single emulsion solvent evaporation technology. The SL-052-PLGA nanoparticles were more effective in PDT treatment of subcutaneous SCCVII squamous cell carcinoma compared to polyvinylpyrrolidone (PVP)-based and standard liposomal SL-052 formulations. A longer time interval between drug injection and tumor illumination can improve tumor cure rates, and SL-052-PLGA nanoparticles showed the best therapeutic effect among all SL-052 formulations.
|
-
- HY-N10778
-
|
|
Others
|
Others
|
|
(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol is a cucurbitane-type triterpenoid. (19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol has been tested to no effect against 5 cancer cell lines, MCF-7, HepG2, Du145, Colon205 and HL-60 by MTT assay .
|
-
- HY-123702
-
|
|
Polo-like Kinase (PLK)
|
Cancer
|
|
CAP-53194 is a selective Plk1 inhibitor with potential anticancer activity. CAP-53194 was identified by a high-throughput virtual screening approach using molecular docking, showing 100-fold selectivity for Plk1 over Plk2-4 and other cell cycle kinases. CAP-53194 is able to effectively exploit subtle differences between the binding sites of Plk1 and other Ser/Thr kinases, thereby enhancing their inhibitory effects. CAP-53194 meets the Lipinski compound analog criteria and passes other ADMET filters, indicating good compound compatibility. CAP-53194 belongs to a new class of potential Plk1 inhibitors suitable for subsequent compound development and testing .
|
-
- HY-N7694
-
|
|
TGF-β Receptor
JAK
STAT
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation .
|
-
- HY-Y0367R
-
|
|
Reference Standards
Endogenous Metabolite
Bacterial
|
Infection
|
|
Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
IC50 & Target: GAD .
In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .
|
-
- HY-118243
-
|
|
Amyloid-β
|
Others
|
|
KMS88009 is a potent small molecule that directly interferes with the formation of amyloid-β oligomers, thereby preserving cognitive behavior when used preventively and reversing cognitive behavior decline when used therapeutically. Oral administration of KMS88009 around the onset of Alzheimer's disease symptoms significantly reduced the assembly of amyloid-β oligomers and improved cognitive behavior in the APP/PS1 double transgenic mouse model. This unique dual mode of action suggests that KMS88009 may be a powerful therapeutic candidate for the treatment of Alzheimer's disease. In an evaluation, the physicochemical properties, pharmacokinetics and toxicity of this anti-amyloidogenic small molecule KMS88009 were studied, as well as post-mortem analysis of APP/PS1 TG mice after behavioral testing.
|
-
- HY-Y0678R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl+) and free bromine (Br+). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
|
-
- HY-114796
-
|
|
Lipoxygenase
|
Inflammation/Immunology
|
|
tHGA is a compound with anti-inflammatory activity and has the activity to inhibit soybean 15-LOX. tHGA showed significant inhibitory effects in experiments on human leukocytes, with an IC50 value of 0.42 μM, which is close to the effect of commonly used standard NDGA. tHGA concentration-dependently inhibits the synthesis of 5-LOX products, especially the cysteine leukotriene LTC(4), with an IC50 value of 1.80 μM. and showed no cytotoxicity. The anti-inflammatory effects of tHGA do not appear to be through redox or metal chelation mechanisms, as the compound was negative in these bioactivity tests. tHGA works through a dual LOX/COX inhibition mechanism and has higher selectivity for 5-LOX and COX-2, with an IC50 value of 0.40 μM .
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-
- HY-W107409
-
|
|
Others
|
Cancer
|
|
Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation .
|
-
- HY-116062A
-
|
|
Histone Methyltransferase
|
Neurological Disease
|
|
JNJ-7925476 is a triple reuptake inhibitor that selectively and potently inhibits the activity of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). JNJ-7925476 is rapidly absorbed into the blood and its concentration in the brain is 7-fold higher than that in plasma. The occupancy ED(50) values of JNJ-7925476 for SERT, NET, and DAT in the rat brain are 0.18, 0.09, and 2.4 mg/kg, respectively. JNJ-7925476 rapidly induces a significant increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex in a dose-dependent manner. JNJ-7925476 exhibits potent antidepressant-like activity in the mouse tail suspension test. These results suggest that JNJ-7925476 has in vivo efficacy in biochemical and behavioral models of depression .
|
-
- HY-W034953
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bathocuproine disulfonate disodium (BCS) is an organic compound used as a highly sensitive colorimetric reagent for copper ions in biochemical and analytical applications. It has a bright yellow color and absorbs light at specific wavelengths, so it can be used to detect and quantify trace copper. In biochemical applications, BCS is commonly used to study the role of copper ions in various biological processes. Copper is an essential nutrient for many organisms, but it can also be toxic in high concentrations, so accurate measurement of copper levels is important to understand its impact on living systems. In terms of analysis, BCS is often used in environmental monitoring and water quality testing to detect copper pollution. It can detect copper even at very low concentrations, making it an invaluable tool for identifying potential sources of pollution and assessing the impact of industrial activities on aquatic ecosystems.
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-
- HY-B1607
-
|
|
Histamine Receptor
SARS-CoV
Filovirus
Parasite
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
Chlorphenoxamine, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease .
|
-
- HY-W011927
-
|
Bisphenol S; Bis(4-hydroxyphenyl) sulfone
|
Estrogen Receptor/ERR
Histone Methyltransferase
Thyroid Hormone Receptor
PI3K
Akt
mTOR
Androgen Receptor
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae .
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-
- HY-W010736A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1,2-Dipalmitoyl-rac-glycerol is a diacylglycerol containing palmitic acid at the sn-1 and sn-2 positions (Cat. No. 10006627). It is found in a variety of vegetable oils, including palm, soybean, canola, and corn. 1 \n 1,2-Dipalmitoyl-rac-glycerol MaxSpec Standard is a quantitative grade standard of 1,2-dipalmitoyl-rac-glycerol prepared for mass spectrometry and related applications requiring quantitative reproducibility . The solution has been prepared gravimetrically and contained in argon-sealed deactivated glass ampoules. Concentrations were verified by comparison to independently prepared calibration standards. This 1,2-dipalmitoyl-rac-glycerol MaxSpec Standard is guaranteed to meet specifications for identity, purity, stability, and concentration and is supplied with a batch-specific Certificate of Analysis. Ongoing stability testing is performed to ensure concentrations remain accurate throughout the shelf life of the product. Note: Add more solution to the vial than listed. Therefore, accurate volume measurements are necessary to prepare calibration standards. Follow recommended storage and handling conditions to maintain product quality.
|
-
- HY-129108
-
|
(9Z)-UAB-30
|
Oct3/4
Microtubule/Tubulin
E1/E2/E3 Enzyme
Proteasome
|
Neurological Disease
Cancer
|
|
9-cis-UAB30 is a rexinoid agonist. 9-cis-UAB30 significantly decreases the proliferation, viability, and motility of both patient-derived xenografts (PDXs). 9-cis-UAB30 induced cell-cycle arrest as demonstrated by the significant increase in the percentage of cells in G1 and a decrease in the percentage of cells in S phase by downregulating SKP2 and/or 20S proteasome activity, which leads to increased p27kip1 protein stability. 9-cis-UAB30 downregulates the abundance of stem cell marker mRNAs (Oct4, Nanog, Sox2, nestin) and upregulates the abundance of differentiation marker mRNAs (β3-tubulin, NSE, HOXC9, GAP43). 9-cis-UAB30 has no adverse effects on the central nervous system and cardiovascular system at the tested dose. 9-cis-UAB30 can be used for the study of neuroblastoma, cutaneous T-cell lymphomas, and breast cancer .
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-
- HY-103117
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
S 32212 hydrochloride is an inverse agonist of 5-HT receptors 5-HT2(CINI) and 5-HT2(CVSV) (Kis=6.6, 8.9 nM) and an antagonist of 5-HT2A and α2β-adrenergic receptors (Ki=5.8, 5.8 nM). S 32212 hydrochloride can reduce the binding of GTPγS to Gαq, and reduce the activity of phospholipase C (PLC) in HEK293 cells expressing 5-HT2(CINI) receptor and CHO cells expressing 5-HT2(CVSV) receptor (EC50=38 and 18.6 nM, respectively). S 32212 hydrochloride (2.5 mg/kg) reduces 5-HT receptor agonist-induced head twitches and penile erections in mice and rats. S 32212 hydrochloride (10, 40 mg/kg) reduces immobility time in the forced swim test and marble burying behavior in mice and rats, exerting antidepressant and anxiolytic activities.
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-
- HY-116161A
-
|
|
Prostaglandin Receptor
|
Endocrinology
|
|
17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.1 The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost.2 This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.3 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative is examined for IOP-lowering activity during the development of latanoprost.4 At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester is the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative is also significantly more irritating to the eye than latanoprost.
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- HY-W011927R
-
|
Bisphenol S (Standard); Bis(4-hydroxyphenyl) sulfone (Standard)
|
Reference Standards
Estrogen Receptor/ERR
Histone Methyltransferase
Thyroid Hormone Receptor
PI3K
Akt
mTOR
Androgen Receptor
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
|
-
- HY-W011927S
-
|
Bisphenol S (4,4'-Sulfonyldiphenol)-d8
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
Histone Methyltransferase
Thyroid Hormone Receptor
PI3K
Akt
mTOR
Androgen Receptor
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
4,4'-Sulfonyldiphenol-d8 (Bisphenol S (4,4'-Sulfonyldiphenol)-d8) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
|
-
- HY-101480
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
Xylamidine is a peripheral 5-HT receptor antagonist used to investigate possible peripheral appetite suppressant effects of 5-hydroxytryptophan (5-HTP) and fenfluramine. In a 1-hour food intake test, xylamidine attenuated the decrease in food intake induced by 5-HT and 5-HTP, but had no effect on fenfluramine, suggesting that the appetite suppressant effect of 5-HTP is mediated in part through peripheral 5-HT receptors. Microstructural analysis revealed that 5-HTP and fenfluramine induced a decrease in food intake rate and a reduction in feeding batch size. Xylamidine reversed the effects of 5-HTP on food intake rate and induced a slight increase in feeding batch size itself, thus, the peripheral effect of 5-HTP appears to be to slow food intake rate. No effect of xylamidine on fenfluramine-induced changes in feeding was observed. The results suggest that the appetite suppressant effects of 5-HTP and fenfluramine are differentiated based on the peripheral effects of 5-HTP. The peripheral effects of 5-HTP are distinct from the previously reported 5-HT-induced decreases in feeding batch size and duration. Possible mechanisms underlying the differences in peripheral effects of 5-HT and 5-HTP are discussed.
|
-
- HY-N16637
-
|
|
NF-κB
PPAR
|
Inflammation/Immunology
|
|
(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside is a diarylheptanol glycoside compound isolated from Tacca plantaginea. (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside significantly inhibit TNF-α-induced NF-κB transcriptional activity (IC50 = 9.4 μM). (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside significantly activates PPAR transcriptional activity (EC50 = 9.9 μM) and has a specific activating effect on PPAR β(δ) (EC50 = 23.1 μM). (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside is non-toxic to cells at the tested concentration. (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside can be used for research on inflammatory conditions .
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-
-
-
HY-L0116V
-
|
|
1,065 compounds
|
|
Macrocycles are promising scaffolds for the design of novel RNA targeting molecules. This collection of macrocycles for RNA consists of very diverse, drug-like molecules which incorporate certain known RNA-recognition elements (e.g. nucleobase ring systems and analogs) distributed within macrocyclic rings or peripheral fragments. As macrocyclic molecules tend to be larger than traditional screening molecules, it is vital to carefully assess and control their physicochemical properties. All macrocycles have been tested for aqueous and DMSO solubility with cutoffs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4); PAMPA permeability has also been tested for representative set of macrocycles.
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-
-
HY-L0115V
-
|
|
10,091 compounds
|
|
ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks.
Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.
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-
-
HY-E0076
-
|
|
0 compounds
|
|
MCE 96-well storage plates are the ideal storage plate for compound library. Conical bottom (V) improves sample recovery and decreases dead volume. MCE 96-well storage plates are completely designed according to ANSI/SBS standards and can be adapted to various testing equipment and automatic workstations.
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-
-
HY-L093
-
|
|
430 compounds
|
|
Food additives are substances added to food to maintain or improve its safety, freshness, taste, texture, or appearance. All food additives used in food undergo a safety assessment, which includes rigorous testing, before they are approved, so all food additives are generally recognized as safe substances.
MCE supplies 430 approved food additives which are safe substances and can be used for drug discovery and other research.
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-
-
HY-L111
-
|
|
3,049 compounds
|
|
MCE Novel Bioactive Compound Library consists of 3,049 bioactive compounds with validated bioactivities tested by cell-based assays or biochemical assays. All compounds in this library are structurally novel and bioactivity diverse which makes it easier to discover new lead compounds. MCE Novel Bioactive Compound Library, as a supplement of MCE bioactive compound library (HY-L001), is a useful tool to screen new lead compounds.
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-
-
HY-L076
-
|
|
636 compounds
|
|
Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug.
DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.
MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 636 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.
|
| Cat. No. |
Product Name |
Type |
-
- HY-D0236
-
|
|
Fluorescent Dye
|
|
Congo Red is an azo dye. Congo Red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections.
|
-
- HY-P0019
-
|
|
Fluorescent Dye
|
|
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
-
- HY-D0830
-
|
Fluorexon tetraethyl ester
|
Fluorescent Dye
|
|
Calcein tetraethyl ester is a fluorescent dye, is used in biology as it can be transported through the cellular membrane into live cells, which makes it useful for testing of cell viability and for short-term labeling of cells.
|
-
- HY-P0019A
-
|
|
Fluorescent Dye
|
|
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
-
- HY-D0222
-
|
|
Fluorescent Dye
|
|
N,N-Dimethyl-1-naphthylamine is an aromatic amine and a dye. N,N-Dimethyl-1-naphthylamine can be used in nitrate reduction test .
|
-
- HY-D1873
-
|
|
Fluorescent Dye
|
|
800CW acid is an orally active near-infrared (NIR) dye (excitation/emission 774/789 nm). 800CW acid can be used for intestinal permeability testing. 800CW acid can be used for in vivo imaging studies .
|
-
- HY-D1571
-
|
|
Fluorescent Dye
|
|
CellTracker Blue CMF2HC Dye is a blue dye, can be used in two-channel nuclei acid sequencing, with blue and purple excitation light (450-460 nm/400-405nm or 415-450 nm/480-525nm). CellTracker Blue CMF2HC Dye can be used to rapid determination of antibiotic sensitivity of microorganisms .
|
-
- HY-D0018
-
|
Dichlorophenylindophenol sodium; DCPIP sodium; Indochlorophenol sodium
|
Fluorescent Dye
|
|
DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. DCIP sodium has unique chemical properties that change color according to the oxidation state of the substance being tested. It is commonly used in enzyme assays, such as measuring the activity of succinate dehydrogenase, or in protein quantification methods, such as the Lowry assay.
|
-
- HY-W134020
-
|
Semixylenol orange
|
Fluorescent Dye
|
|
Semixylenol orange is a metallochromic indicator that can complex with various metal ions and is used for the testing and analysis of metal ions such as zinc and zirconium .
|
-
- HY-D0236R
-
|
|
Fluorescent Dye
|
|
Congo Red (Standard) is the analytical standard of Congo Red. This product is intended for research and analytical applications. Congo Red is an azo dye. Congo Red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections.
|
-
- HY-D0800
-
|
|
Fluorescent Dye
|
|
Chromeazurol S is a compound belonging to the class of azo dyes. It is often used as an indicator in analytical chemistry to detect metal ions such as copper, nickel, and cobalt. Chromeazurol S turns from yellow to blue in the presence of metal ions, allowing them to be detected and quantified. It can be applied to a test strip or added directly to a solution for analysis.
|
-
- HY-D0945
-
|
|
Fluorescent Dye
|
|
Xylene Cyanol FF is an acid triphenylmethane dye. Xylene Cyanol FF can be used for histochemical staining of hemoglobin peroxidase or as a tracking dye for DNA sequencing in electrophoresis. Xylene Cyanol FF will be catalyzed by Fe and Al to accelerate oxidation under the addition of double oxidant hydrogen peroxide and potassium periodate. Xylene Cyanol FF thus enables the spectrophotometric determination of Fe and Al in the solution to be tested .
|
-
- HY-D0018R
-
|
Dichlorophenylindophenol sodium (Standard); DCPIP sodium (Standard); Indochlorophenol sodium (Standard)
|
Fluorescent Dye
|
|
DCIP (sodium) (Standard) is the analytical standard of DCIP (sodium). This product is intended for research and analytical applications. DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. DCIP sodium has unique chemical properties that change color according to the oxidation state of the substance being tested. It is commonly used in enzyme assays, such as measuring the activity of succinate dehydrogenase, or in protein quantification methods, such as the Lowry assay.
|
-
- HY-D0228
-
|
Azo Violet; Magneson I
|
Fluorescent Dye
|
|
4-(4-Nitrophenylazo)resorcinol is an azo purple dye used experimentally as a pH indicator, showing yellow when the pH value is lower than 11 and purple when the pH value is higher than 13. In slightly alkaline or alkaline environments, it also turns dark blue in the presence of magnesium salts. Azo Violet can also be used to test for the presence of ammonium ions. The color of the ammonium chloride or ammonium hydroxide solution will change depending on the concentration of azo violet used.
|
-
- HY-D0970
-
|
Direct Blue 14; Trypan Blue
|
Fluorescent Dye
|
|
Diphenyl Blue (Trypan Blue) is a cell active dye, the most commonly used dye for the identification of dead cells, of en used to test cell membrane integrity and cell viability. Diphenyl Blue staining is one of the methods for tissue and cell culture. When cells are deactivated or have incomplete cell membranes, Diphenyl Blue can stain them Blue. Normal living cells with intact cell membranes reject Diphenyl blue and do not stain them blue. However, macrophages are capable of phagocytosis of Diphenyl Blue, so it can be used as a living stain for macrophages .
|
| Cat. No. |
Product Name |
Type |
-
- HY-W025736
-
|
|
Biochemical Assay Reagents
|
|
5-Amino-2-methoxyphenol is a phenolic regioisomer. 5-Amino-2-methoxyphenol produces dose-dependent antinociception in the mouse formalin test, with its second-phase effect being mechanistically dependent on both FAAH and TRPV1. 5-Amino-2-methoxyphenol can be used for antinociception research .
|
-
- HY-15913
-
|
|
Biochemical Assay Reagents
|
|
DAOS, a Trinder's reagent, is a novel highly water-soluble aniline derivative; are widely used in diagnostic tests and biochemical tests.
|
-
- HY-15918
-
|
|
Biochemical Assay Reagents
|
|
HDAOS is a novel Trinder's reagent, which is a highly water-soluble aniline derivative. HDAOS is widely used in diagnostic tests and biochemical tests .
|
-
- HY-W134423
-
|
|
Biochemical Assay Reagents
|
|
Agar, microbiology tested, for cell culture (powder) is a jelly like substance that contains agarose and agar gel. Agar, microbiology tested, for cell culture (powder) can be isolated from the cell walls of red algae species such as Gelidium and Gracilaria (Ogonori). The gelation and melting of Agar, microbiology tested, for cell culture (powder) is based on the hydrogen bridge (physical gels), so the gelation is reversible. Agar, microbiology tested, for cell culture (powder) is widely used in food additives, plant tissue culture, microorganisms culture media, fingerprint recognition, and medical fields .
|
-
- HY-W127350
-
|
|
Biochemical Assay Reagents
|
|
Cholesterol Pelargonate, a Cholesterol derivative, can be used as a triggered release liposome tested .
|
-
- HY-157376
-
|
|
Biochemical Assay Reagents
|
|
Casein Agar can be used for casein decomposition test of Bacillus cereus. The composition of 1 liter of Casein Agar contains contains: 10.0 g casein, 3.0 g beef infusion powder, 5.0 g sodium chloride, 2.0 g dipotassium hydrogen phosphate and 15.0 g agar .
|
-
- HY-B1610ER
-
|
Trisodium citrate dihydrate, meets USP testing specifications (Standard)
|
Biochemical Assay Reagents
|
|
Sodium citrate dihydrate, meets USP testing specifications (Standard) is the analytical standard of Sodium citrate dihydrate, meets USP testing specifications. This product is intended for research and analytical applications. Sodium citrate dihydrate, meets USP testing specifications is an anticoagulant and also used as a buffer and food preservatives .
|
-
- HY-W795008
-
|
|
Biochemical Assay Reagents
|
|
Deoxyribonucleic acid, single stranded from salmon testes is a sodium salt of deoxyribonucleic acid from salmon testes that has been used in basal media for the anaerobic growth of several strains of Bacillus mojavei. Deoxyribonucleic acid, single stranded from salmon testes can also be used as a substrate for the development of DNA detection assays .
|
-
- HY-B2243H
-
|
Sodium phosphate monobasic (USP); Monosodium dihydrogen orthophosphate (USP); Monosodium phosphate (USP)
|
Biochemical Assay Reagents
|
|
Anhydrous sodium dihydrogen phosphate, meets USP testing specifications is an inorganic salt. It is a chemical compound of sodium with a phosphate counter ion. Anhydrous sodium dihydrogen phosphate, meets USP testing specifications can be used as a pH buffer with other sodium phosphates .
|
-
- HY-W105639A
-
|
Calcium lactate pentahydrate, meets USP testing specifications
|
Biochemical Assay Reagents
|
|
Calcium L-lactate pentahydrate, meets USP testing specifications (Calcium lactate pentahydrate, meets USP testing specifications) is a biochemical reagent and serves as one of the important sources of calcium. Compared to other organic calcium salts, Calcium L-lactate pentahydrate, meets USP testing specifications exhibits excellent solubility and bioavailability. Calcium L-lactate pentahydrate, meets USP testing specifications possesses remarkable moisture resistance, thermal stability, and chemical stability and can be used in medical implants and drug delivery systems .
|
-
- HY-Y0319B2
-
|
|
Biochemical Assay Reagents
|
|
Potassium acetate, meets USP testing specifications is an inorganic salt that can be used for life science related research .
|
-
- HY-B1610E
-
|
Trisodium citrate dihydrate, meets USP testing specifications
|
Biochemical Assay Reagents
|
|
Sodium citrate dihydrate, meets USP testing specifications is an anticoagulant and also used as a buffer and food preservatives .
|
-
- HY-W134423B
-
|
|
Biochemical Assay Reagents
|
|
Agar, meets USP testing specifications is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-172445
-
|
SS-DNA
|
Biochemical Assay Reagents
|
|
Deoxyribonucleic acid sodium salt from salmon testes (ssstDNA) can be used to make anti-adhesion layers (AALs) for passivating gold plasmonic sensor surfaces .
|
-
- HY-W134020
-
|
Semixylenol orange
|
Biochemical Assay Reagents
|
|
Semixylenol orange is a metallochromic indicator that can complex with various metal ions and is used for the testing and analysis of metal ions such as zinc and zirconium .
|
-
- HY-W134423A
-
|
|
Biochemical Assay Reagents
|
|
Agar, microbiology tested, for cell culture (granular) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-W087892
-
|
|
Biochemical Assay Reagents
|
|
Barium diphenylamine-4-sulfonate can be employed as an intermediate in pharmaceutical manufacturing and in chemical research, and serves as a dosing agent in analytical testing .
|
-
- HY-D0158
-
-
- HY-157366
-
|
|
Biochemical Assay Reagents
|
|
Sulfite Agar can be used for the test tube count of anaerobic Reductobacter sulfite. The composition of 1 litre medium is 31 g Sulfite Agar .
|
-
- HY-157357
-
|
|
Biochemical Assay Reagents
|
|
Fungi Agar Medium can be used in sterile growth tests. Fungi Agar Medium ingredients include peptone, glucose, yeast powder, potassium dihydrogen phosphate, magnesium sulfate, and agar.
|
-
- HY-D0867
-
|
|
Biochemical Assay Reagents
|
|
BES is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES is used in the diagnostic testing area.
|
-
- HY-D0867A
-
|
|
Biochemical Assay Reagents
|
|
BES sodium is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES sodium is used in the diagnostic testing area.
|
-
- HY-B1620
-
|
PVP K30; Polyvidone K30; Povidone K30
|
Biochemical Assay Reagents
|
|
Polyvinylpyrrolidone K30 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.
|
-
- HY-157349
-
|
BGLB
|
Biochemical Assay Reagents
|
|
Brilliant Green Lactose Bile Broth can be used for confirmatory testing of coliform bacteria. The ingredients of Blood Enrichment Medium include tryptone, lactose, ox bile powder, and brilliant green .
|
-
- HY-W293502
-
|
2-Chloro-4-nitrophenyl-beta-D-galactopyranoside
|
Biochemical Assay Reagents
|
|
2-Chloro-4-nitrophenyl-β-D-galactopyranoside is a chromogenic substrate used for testing enzyme activity. It is commonly used in molecular biology research to detect and measure the activity of β-galactosidase (biosynth: EC03318).
|
-
- HY-137425
-
|
|
Biochemical Assay Reagents
|
|
N-Biotinyl-12-aminododecanoic acid is a compound formed by linking biotin and 12-aminododecanoic acid through an amide bond. N-Biotinyl-12-aminododecanoic acid is used as a biotinylation reagent to test the ligation activity of SimL .
|
-
- HY-W010169
-
|
|
Biochemical Assay Reagents
|
|
Sodium 4-aminobenzoate is a biochemical assay reagent. According to its structure, sodium 4-aminobenzoate exhibits antioxidant, anticoagulant, fubrinolytic and immunomodulating activities, and can be utilized as a protective agent against UV-irradiation and in diagnostic tests for the state of the gastrointestinal tract .
|
-
- HY-Y1083H
-
|
Salt of lemery, 99%
|
Biochemical Assay Reagents
|
|
Potassium sulfate, 99% (Salt of lemery, 99%) can be used in biochemical tests for serum proteins, the determination of blood potassium and other potassium salts, and the preparation of protein capillary electrophoresis buffers. Potassium sulfate, 99% is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-Y1083C
-
|
Salt of lemery, for cell culture
|
Biochemical Assay Reagents
|
|
Potassium sulfate, for cell culture (Salt of lemery, for cell culture) can be used in biochemical tests for serum proteins, the determination of blood potassium and other potassium salts, and the preparation of protein capillary electrophoresis buffers. Potassium sulfate, for cell culture is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-130751
-
DODAP
1 Publications Verification
|
Biochemical Assay Reagents
|
|
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
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-
- HY-D0177
-
|
Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
|
Biochemical Assay Reagents
|
|
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) is a peptide coupling reagent and BOP analog. (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate promotes the reaction of amino and carboxyl groups to form peptide bonds. (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate can be used in the synthesis of peptide compounds
|
-
- HY-157360
-
|
|
Biochemical Assay Reagents
|
|
Acetamide Agar is a solid culture media for non-fermenting bacteria. Acetamide Agar helps differentiate P. acidovorans from other non-sugar-soluble or weakly sugar-soluble Pseudomonas species. Acetamide Agar can be used to test the ability of microorganisms such as Pseudomonas aeruginosa to utilize acetamide through deamination .
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-
- HY-W087892R
-
|
|
Biochemical Assay Reagents
|
|
Barium diphenylamine-4-sulfonate (Standard) is the analytical standard of Barium diphenylamine-4-sulfonate. This product is intended for research and analytical applications. Barium diphenylamine-4-sulfonate can be employed as an intermediate in pharmaceutical manufacturing and in chemical research, and serves as a dosing agent in analytical testing .
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-
- HY-D0800
-
|
|
Biochemical Assay Reagents
|
|
Chromeazurol S is a compound belonging to the class of azo dyes. It is often used as an indicator in analytical chemistry to detect metal ions such as copper, nickel, and cobalt. Chromeazurol S turns from yellow to blue in the presence of metal ions, allowing them to be detected and quantified. It can be applied to a test strip or added directly to a solution for analysis.
|
-
- HY-15904
-
|
ESPA
|
Biochemical Assay Reagents
|
|
N-Ethyl-N-(3-sulfopropyl)-m-anisidine sodium (ESPA) is a Trinder's reagent and a highly water-soluble aniline derivative. N-Ethyl-N-(3-sulfopropyl)-m-anisidine sodium has a relatively high absorption wavelength at 540 nm and can be widely used in diagnostic tests and biochemical experiments .
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-
- HY-W110794
-
|
|
Biochemical Assay Reagents
|
|
Crystal violet, IND (0.0-2.0) is a specialized indicator suitable for strongly acidic systems, which reflects changes in pH within the range of 0.0-2.0 through color changes. Crystal violet, IND (0.0-2.0) is widely used in acid-base titration, chemical analysis, and industrial testing fields .
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-
- HY-D0945
-
|
|
Biochemical Assay Reagents
|
|
Xylene Cyanol FF is an acid triphenylmethane dye. Xylene Cyanol FF can be used for histochemical staining of hemoglobin peroxidase or as a tracking dye for DNA sequencing in electrophoresis. Xylene Cyanol FF will be catalyzed by Fe and Al to accelerate oxidation under the addition of double oxidant hydrogen peroxide and potassium periodate. Xylene Cyanol FF thus enables the spectrophotometric determination of Fe and Al in the solution to be tested .
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-
- HY-D0007
-
|
Tetrazolium blue
|
Biochemical Assay Reagents
|
|
Blue Tetrazolium (Tetrazolium blue), as a blue dye for microbial research, can be reduced into blue tetrazolium formazan (BTF). Blue Tetrazolium can be used to determine the activity of succinate dehydrogenase (SDH) in yeast strains, which has been reduced as a substrate. Use DMSO to extract BTF from cells, and test absorption spectrum of BTF. The BTF shows a wide wavelength range of 480-600 nm with maximal absorbance seen at 540 nm. Blue Tetrazolium, combines with succinate dehydrogenase (SDH) .
|
-
- HY-15929
-
TBHBA
1 Publications Verification
2,4,6-Tribromo-3-hydroxybenzoic acid
|
Biochemical Assay Reagents
|
|
TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a chemical colorimetric agent and nanomaterial surface modifier. TBHBA can react with some oxidants (such as H2O2) to generate high-absorbance quinoneimine dyes, which enhance the sensitivity of HDL cholesterol enzymatic determination. TBHBA can be used as a bromine-containing coupling agent to modify the surface of silica nanoparticles through esterification reaction. Thereby, organic flame retardant groups are introduced to improve the thermal stability and flame retardant properties of nanocomposites. TBHBA can be used in clinical biochemical testing (such as serum lipoprotein analysis) and the preparation of flame-retardant polymer nanocomposites .
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-
- HY-W034953
-
|
|
Biochemical Assay Reagents
|
|
Bathocuproine disulfonate disodium (BCS) is an organic compound used as a highly sensitive colorimetric reagent for copper ions in biochemical and analytical applications. It has a bright yellow color and absorbs light at specific wavelengths, so it can be used to detect and quantify trace copper. In biochemical applications, BCS is commonly used to study the role of copper ions in various biological processes. Copper is an essential nutrient for many organisms, but it can also be toxic in high concentrations, so accurate measurement of copper levels is important to understand its impact on living systems. In terms of analysis, BCS is often used in environmental monitoring and water quality testing to detect copper pollution. It can detect copper even at very low concentrations, making it an invaluable tool for identifying potential sources of pollution and assessing the impact of industrial activities on aquatic ecosystems.
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-
- HY-W011927
-
|
Bisphenol S; Bis(4-hydroxyphenyl) sulfone
|
Biochemical Assay Reagents
|
|
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae .
|
-
- HY-W010736A
-
|
|
Biochemical Assay Reagents
|
|
1,2-Dipalmitoyl-rac-glycerol is a diacylglycerol containing palmitic acid at the sn-1 and sn-2 positions (Cat. No. 10006627). It is found in a variety of vegetable oils, including palm, soybean, canola, and corn. 1 \n 1,2-Dipalmitoyl-rac-glycerol MaxSpec Standard is a quantitative grade standard of 1,2-dipalmitoyl-rac-glycerol prepared for mass spectrometry and related applications requiring quantitative reproducibility . The solution has been prepared gravimetrically and contained in argon-sealed deactivated glass ampoules. Concentrations were verified by comparison to independently prepared calibration standards. This 1,2-dipalmitoyl-rac-glycerol MaxSpec Standard is guaranteed to meet specifications for identity, purity, stability, and concentration and is supplied with a batch-specific Certificate of Analysis. Ongoing stability testing is performed to ensure concentrations remain accurate throughout the shelf life of the product. Note: Add more solution to the vial than listed. Therefore, accurate volume measurements are necessary to prepare calibration standards. Follow recommended storage and handling conditions to maintain product quality.
|
-
- HY-W011927R
-
|
Bisphenol S (Standard); Bis(4-hydroxyphenyl) sulfone (Standard)
|
Biochemical Assay Reagents
|
|
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-137367
-
|
|
Cathepsin
|
Infection
|
|
Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins .
|
-
- HY-P1173
-
|
Myristoylated L 803; GSK-3β Inhibitor XIII
|
GSK-3
Amyloid-β
|
Neurological Disease
|
|
L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test .
|
-
- HY-B1493
-
|
|
Peptides
|
Endocrinology
|
|
Bentiromide is a peptide that is broken down in the pancreas by chymotrypsin. The bentiromide test is an excellent means of confirming the diagnosis of pancreatic exocrine insufficiency by outpatient test of chymotrypsin function .
|
-
- HY-P4476
-
|
|
Ser/Thr Protease
|
Others
|
|
Suc-AAPA-pNA is a substrate of chymotrypsin Aα. Suc-AAPA-pNA can be used to test chymotrypsin Aα activity .
|
-
- HY-B1493R
-
|
|
Biochemical Assay Reagents
Reference Standards
|
Endocrinology
|
|
Bentiromide (Standard) is the analytical standard of Bentiromide. This product is intended for research and analytical applications. Bentiromide is a peptide that is broken down in the pancreas by chymotrypsin. The bentiromide test is an excellent means of confirming the diagnosis of pancreatic exocrine insufficiency by outpatient test of chymotrypsin function .
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-
- HY-P10276
-
|
|
Caspase
|
Cancer
|
|
Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .
|
-
- HY-P4449
-
|
|
Caspase
|
Cancer
|
|
Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
|
-
- HY-P4458
-
|
|
Ser/Thr Protease
|
Cancer
|
|
Boc-QAR-pNA is a chromogenic substrate of trypsin. Boc-QAR-pNA can be used to test trypsin activity .
|
-
- HY-P4460
-
|
|
Ser/Thr Protease
|
Cancer
|
|
AAA-pNA is a chromogenic substrate of Tripeptidyl-peptidase II. AAA-pNA can be used to test Tripeptidyl-peptidase II activity .
|
-
- HY-P4482
-
|
|
Bacterial
|
Infection
|
|
Suc-AAPE-pNA is a chromogenic substrate of glutamyl endopeptidase. Suc-AAPE-pNA can be used to test glutamyl endopeptidase activity .
|
-
- HY-P4455
-
|
|
Bacterial
|
Infection
|
|
Boc-AAG-pNA is a glycine endopeptidase substrate. Boc-AAG-pNA can be used to test the amidase activity glycine endopeptidase .
|
-
- HY-W713878
-
|
|
Caspase
|
Others
|
|
Ac-VDVAD-pNA is a caspase-2 substrate. Ac-VDVAD-pNA can be used to test the activity of caspase-2 .
|
-
- HY-P10189
-
-
- HY-P4449A
-
|
|
Caspase
|
Cancer
|
|
Ac-VRPR-AMC TFA is a fluorogenic metacaspase substrate. Ac-VRPR-AMC TFA can be used to assay metacaspase activity .
|
-
- HY-P4464
-
|
|
Ser/Thr Protease
|
Cancer
|
|
Ala-Phe-Pro-pNA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA can be used to test tripeptidyl peptidase activity .
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-
- HY-P4477
-
|
|
Ser/Thr Protease
|
Others
|
|
Suc-AAPR-pNA is a substrate of trypsin acyl-enzymes. Suc-AAPR-pNA can be used to test trypsin acyl-enzymes activity .
|
-
- HY-P4470
-
|
|
Ser/Thr Protease
|
Cancer
|
|
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .
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-
- HY-P10191
-
|
|
Peptides
|
Others
|
|
β-Secretase Substrate-1, Fluorogenic is a fluorogenic substrate of β-Secretase that can be used to test β-Secretase activity .
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-
- HY-P4464A
-
|
|
Ser/Thr Protease
|
Cancer
|
|
Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA TFA can be used to test tripeptidyl peptidase activity .
|
-
- HY-P4475
-
-
- HY-P4453
-
|
|
Caspase
|
Cancer
|
|
Boc-Ala-Ala-Asp-pNA is a chromogenic substrate of granzyme B. Boc-Ala-Ala-Asp-pNA can be used to test functional activity of granzyme B .
|
-
- HY-P0019
-
-
- HY-P0019A
-
|
|
Fluorescent Dye
Thrombin
|
Others
|
|
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
-
- HY-P10435
-
|
|
Dopamine Receptor
|
Neurological Disease
|
|
KEMPFPKYPVEP is a 12-amino acids neuropeptide, which upregulates levels of dopamine (DA) and norepinephrine (NE) in the prefrontal cortex, exhibits spatial and object recognition memory promoting ability in Scopolamine (HY-N0296)-induced amnesia mouse model .
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-
- HY-P1771
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
OVA G4 peptide is a variant of the agonist ovalbumin (OVA) peptide SIINFEKL (257-264). SIINFEKL is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel .
|
-
- HY-P10533
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Cysteine peptide is a heptapeptide containing a cysteine residue whose thiol group makes it susceptible to a range of oxidative modifications. Cysteine peptide is used to detect the skin sensitization potential of chemicals including cosmetic ingredients .
|
-
- HY-P1771A
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
OVA G4 peptide TFA is a variant of the agonist ovalbumin (OVA) peptide SIINFEKL (257-264). SIINFEKL is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel .
|
-
- HY-134113
-
|
CBZ-Chromozym TH
|
Peptides
|
Others
|
|
Z-Gly-Pro-Arg-pNA (z-GPR-pNA) is a photometric substrate in Prostate-Specific Antigen (PSA) activation protease assays. Z-Gly-Pro-Arg-pNA (z-GPR-pNA) can be used for the test of trypsin activity .
|
-
- HY-120757
-
|
|
Virus Protease
|
Others
|
|
LP-130 is a statin-based inhibitor that is a universal inhibitor with nanomolar inhibitory activity against all tested retroviral proteases. Crystal structure studies of its binding to different retroviral proteases have shown that it can adapt to different active site regions to achieve inhibition.
|
-
- HY-P1746
-
|
PKC (19-31)
|
PKC
|
Inflammation/Immunology
|
|
Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .
|
-
- HY-P1746A
-
|
PKC (19-31) (TFA)
|
PKC
|
Inflammation/Immunology
|
|
Protein Kinase C (19-31) TFA, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .
|
-
- HY-P1299A
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
UFP-101 TFA is a potent, selective, and competitive antagonist of the N/OFQ peptide (NOP) receptor, with a pKi of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect .
|
-
- HY-P1299
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pKi of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect .
|
-
- HY-P4466
-
|
|
HIV Protease
|
Infection
|
|
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease. Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 can be used to test HIV-1 protease activity .
|
-
- HY-P5296
-
|
|
Fluorescent Dye
|
Others
|
|
Dabsyl-Leu-Gly-Gly-Gly-Ala-Edans is a fluorophore Dabsyl-labeled peptide. Dabsyl-Leu-Gly-Gly-Gly-Ala-Edans can be used to test the peptidase activity of the LasA protease of Pseudomonas aeruginosa. Dabsyl-Leu-Gly-Gly-Gly-Ala-Edans has enzyme specificity and has application value .
|
-
- HY-P0019B
-
|
|
Fluorescent Dye
Thrombin
|
Others
|
|
Z-Gly-Gly-Arg-AMC TFA is the TFA salt form of Z-Gly-Gly-Arg-AMC (HY-P0019). Z-Gly-Gly-Arg-AMC TFA is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
-
- HY-P5486
-
|
|
Bacterial
|
Others
|
|
Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)
|
-
- HY-P10203
-
|
|
Opioid Receptor
|
Inflammation/Immunology
|
|
μ/κ/δ opioid receptor agonist 1 is a μ opioid receptor (MOR), κ opioid receptor (KOR), and δ opioid receptor (DOR) agonist. μ/κ/δ opioid receptor agonist 1 produces a strong and long-lasting analgesic effect through peripheral MOR and KOR in the tail-flick test .
|
-
- HY-W003222
-
|
|
Drug Intermediate
|
Metabolic Disease
|
|
N-tert-Boc-cis-4-fluoro-L-proline (Compound 11) is a drug intermediate for the synthesis of 4-fluoropyrrolidine-2-carbonitrile DPP-4 inhibitor. N-tert-Boc-cis-4-fluoro-L-proline can be used to study type 2 diabetes .
|
-
- HY-P0165B
-
|
ITM077 acetate; R1583 acetate; BIM51077 acetate
|
GLP Receptor
|
Metabolic Disease
|
|
Taspoglutide (R1583) acetate is an agonist of the glucagon-like peptide 1 receptor (GLP-1R) with an Ki value of 1.1 nM. Taspoglutide acetate induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). Taspoglutide acetate decreases blood levels of glucose and increases blood levels of insulin in a glucose tolerance test in Zucker diabetic obese rats. Taspoglutide acetate reduces blood levels of gastric inhibitory polypeptide (GIP), plasma levels of triglycerides, and body weight in the same model .
|
-
- HY-P1441A
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-B1908
-
-
-
- HY-W040790
-
-
-
- HY-17568
-
-
-
- HY-101410
-
-
-
- HY-N4111
-
-
-
- HY-121345
-
-
-
- HY-N5067
-
-
-
- HY-122997
-
-
-
- HY-N4111R
-
-
-
- HY-116108
-
-
-
- HY-125652
-
-
-
- HY-N15703
-
-
-
- HY-N0006
-
-
-
- HY-N0006R
-
-
-
- HY-17568R
-
-
-
- HY-W040156
-
|
|
Natural Products
Microorganisms
Source classification
|
Fungal
|
|
Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process .
|
-
-
- HY-126787
-
-
-
- HY-N4173R
-
|
|
other families
Stilbenes
Source classification
Plants
|
Reference Standards
Drug Metabolite
|
|
p-Dimethylaminobenzaldehyde (Standard) is the analytical standard of p-Dimethylaminobenzaldehyde. This product is intended for research and analytical applications. p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde) is an organic compound containing amine and aldehyde moieties which is used in Ehrlich's reagent and Kovac's reagent to test for indoles .
|
-
-
- HY-101410R
-
-
-
- HY-N4227
-
|
|
Natural Products
Animals
Source classification
|
Others
|
|
Conicasterol is a 4-mercaptosteroid with significant cytotoxic activity. Conicasterol showed an IC50 value of 6.23 μg/mL in a test on a human breast adenocarcinoma cell line (MCF-7). Conicasterol's antitumor activity makes it a potential bioactive lead molecule .
|
-
-
- HY-N13082
-
-
-
- HY-N11919
-
-
-
- HY-N5054
-
-
-
- HY-117845
-
|
LL-E19085α
|
Microorganisms
Antibiotics
Source classification
|
Bacterial
Antibiotic
|
|
Citreamicin alpha (LL-E 19085-alpha) is an antibiotic whose in vitro antimicrobial activity against 429 clinical isolates of Gram-positive cocci has been tested by the agar dilution method. These microorganisms included 313 strains of Staphylococci and 116 strains of Streptococci. The in vitro activity of Citreamicin alpha was compared with that of ampicillin, amoxicillin, ceftriaxone, erythromycin, and vancomycin. For Staphylococci, the MIC values of Citreamicin alpha ranged from 0.12-4.0 μg/ml, and for Streptococcus pyogenes of the genus Streptococcus, it was 0.03-0.12 μg/ml. However, enterococci were relatively resistant, requiring 2.0 μg/ml of the agent to inhibit 64% of the 62 tested strains. The in vitro activity of this antibiotic was much better than that of ampicillin, amoxicillin, ceftriaxone, and erythromycin, but comparable or slightly inferior to that of vancomycin.
|
-
-
- HY-N15112
-
-
-
- HY-N0446
-
-
-
- HY-N15508
-
|
|
Microorganisms
Terpenoids
Source classification
Diterpenoids
|
NO Synthase
|
|
Harzianoside B is a diterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Harzianoside B has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value is close to the maximum tested concentration of 100 µM. It can be used in the research of the anti-inflammatory field .
|
-
-
- HY-W040156R
-
|
|
Natural Products
Microorganisms
Source classification
|
Fungal
Reference Standards
|
|
Oxadixyl (Standard) is the analytical standard of Oxadixyl. This product is intended for research and analytical applications. Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process .
|
-
-
- HY-W015780
-
-
-
- HY-13643
-
-
-
- HY-N6771
-
-
-
- HY-N0446R
-
-
-
- HY-126596
-
|
|
Quinones
Alkanna tinctoria (L.) Tausch
Source classification
Plants
Naphthalene Quinones
Boraginaceae
|
Apoptosis
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Angelylalkannin is a naphthoquinone compound isolated from the root of Alkanna tinctoria. Angelylalkannin showed significant inhibitory effects in the antiproliferative effect test on human colon cancer cells HCT-116 and SW-480. The median inhibitory concentration (IC50) of Angelylalkannin was 4.76 mM for HCT-116 cells and 7.03 mM for SW-480 cells. Like alkannin, Angelylalkannin can arrest the cell cycle in the G1 phase and induce apoptosis at a concentration of 1-10 mM.
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- HY-119821R
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Microorganisms
Source classification
Phenols
Polyphenols
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Reference Standards
Glycosidase
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Thiamiprine (Standard) is the analytical standard of Thiamiprine. This product is intended for research and analytical applications. Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.
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- HY-13643R
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- HY-N3017
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- HY-N11997
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Liliaceae
Source classification
Coumarins
Phenols
Polyphenols
Aloe vera (L.) Burm. f.
Phenylpropanoids
Plants
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Cholinesterase (ChE)
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Feralolide is a dihydroisocoumarin isolated from the methanolic extract of aloe vera resin. Feralolide is also a dual inhibitor of AChE and BuChE, with IC50s of 55 μg/mL and 52 μg/mL respectively. Feralolide has antioxidant activity and inhibits 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Feralolide could be used in research into cognitive disorders such as Alzheimer's disease, potentially restoring and enhancing memory .
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- HY-N15309
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Torvoside K
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Polysaccharides
Source classification
Solanum torvum Swartz
Solanaceae
Plants
Saccharides
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Fungal
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Torvoside C (Torvoside K) is a compound found in Solanum torvum with antifungal activity. The ZOIs and MIC values of Torvoside C against the tested fungi (Alternaria brassicicola, Alternaria geophila, Aspergillus flavus, etc.) range from 33.4% to 87.4% and 31.25 to 250 μg/mL, respectively. Additionally, it exhibits a dose-dependent inhibitory effect on the production of mycotoxins aflatoxin B1 and fumonisin B1, which are produced by A. flavus and F. verticillioides, respectively. Torvoside C can be used for research in the field of antifungal infection .
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- HY-N3887
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Haplophytin B; Haplophytine B
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Alkaloids
Other Alkaloids
Source classification
Rutaceae
Plants
Haplophyllum acutifolium (DC.) G. Don
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Bacterial
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Evoxine (Haplophytin B) is a compound that selectively inhibits CO2-induced immunosuppression and has activity in inhibiting the expression of interleukin-6 and chemokine CCL2 in human THP-1 macrophages. Evoxine shows antimicrobial activity against a wide range of bacteria, especially performing well in minimum inhibitory concentration (MIC) tests against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. Evoxine extracts may find application in crude drug preparations in West Africa, provided that their in vivo toxicity results are negative .
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- HY-W015786R
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Monophenols
Source classification
Phenols
Endogenous metabolite
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Reference Standards
Bacterial
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L-Amoxicillin (Standard) is the analytical standard of L-Amoxicillin. This product is intended for research and analytical applications. L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .
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- HY-N8487
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- HY-Y0678
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TRIMETHYL PHLOROGLUCINOL
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Natural Products
Source classification
Rosaceae
Plants
Rosa rugosa Thunb.
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Others
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1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl +) and free bromine (Br +). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
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- HY-N10778
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Triterpenes
Terpenoids
Source classification
Cucurbitaceae
Plants
Momordica charantia Linn.
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Others
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(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol is a cucurbitane-type triterpenoid. (19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol has been tested to no effect against 5 cancer cell lines, MCF-7, HepG2, Du145, Colon205 and HL-60 by MTT assay .
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- HY-N7694
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- HY-Y0367R
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Structural Classification
Immune System Disorder
Ketones, Aldehydes, Acids
Source classification
Disease markers
Endogenous metabolite
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Reference Standards
Endogenous Metabolite
Bacterial
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Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
IC50 & Target: GAD .
In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .
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- HY-Y0678R
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Natural Products
Source classification
Rosaceae
Plants
Rosa rugosa Thunb.
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Biochemical Assay Reagents
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1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl+) and free bromine (Br+). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
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- HY-W107409
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Alkaloids
Other Alkaloids
Marine natural products
Source classification
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Others
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Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation .
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- HY-N16637
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Structural Classification
Source classification
Phenols
Polyphenols
Schizocapsa plantaginea Hance
Plants
Taccaceae
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NF-κB
PPAR
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(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside is a diarylheptanol glycoside compound isolated from Tacca plantaginea. (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside significantly inhibit TNF-α-induced NF-κB transcriptional activity (IC50 = 9.4 μM). (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside significantly activates PPAR transcriptional activity (EC50 = 9.9 μM) and has a specific activating effect on PPAR β(δ) (EC50 = 23.1 μM). (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside is non-toxic to cells at the tested concentration. (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside can be used for research on inflammatory conditions .
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-118877
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1 Publications Verification
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Urea- 13C is the 13C labelled urea. The Urea- 13C breath test ( 13C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection .
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- HY-Y0258S
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Benzocaine-d4 is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
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- HY-Y0258S1
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Benzocaine-(ethyl-d5) is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
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- HY-W011927S
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1 Publications Verification
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4,4'-Sulfonyldiphenol-d8 (Bisphenol S (4,4'-Sulfonyldiphenol)-d8) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
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- HY-W654381
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N-Vanillylnonanamide-d3 is the deuterium labeled Nonivamide (HY-17568). Nonivamide is a 50 value of 5.1 mg/L in static toxicity tests.
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- HY-122984S
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Diquat-d4 (dibromide) is the deuterium labeled Diquat dibromide (HY-122984) . Diquat dibromide is a comprehensive herbicide commonly used in the cultivation of cotton, soybeans, and other crops to combat unwanted weeds. Diquat dibromide has an IC50 of 60 mg/L in the Allium root growth inhibition test .
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- HY-W743258
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L-Amoxicillin-d4 sodium is the deuterium labeled L-Amoxicillin (HY-129836). L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .
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| Cat. No. |
Product Name |
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Classification |
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- HY-W134423
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Thickeners
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Agar, microbiology tested, for cell culture (powder) is a jelly like substance that contains agarose and agar gel. Agar, microbiology tested, for cell culture (powder) can be isolated from the cell walls of red algae species such as Gelidium and Gracilaria (Ogonori). The gelation and melting of Agar, microbiology tested, for cell culture (powder) is based on the hydrogen bridge (physical gels), so the gelation is reversible. Agar, microbiology tested, for cell culture (powder) is widely used in food additives, plant tissue culture, microorganisms culture media, fingerprint recognition, and medical fields .
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- HY-W127350
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Cholesterol
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Cholesterol Pelargonate, a Cholesterol derivative, can be used as a triggered release liposome tested .
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- HY-B1620
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PVP K30; Polyvidone K30; Povidone K30
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Disintegrants
Suspending Agents
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Polyvinylpyrrolidone K30 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.
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- HY-130751
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DODAP
1 Publications Verification
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Cationic Lipids
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DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
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- HY-153489A
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ISIS-CRPRx sodium
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Antisense Oligonucleotides
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ISIS 329993 sodium is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx sodium has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis
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- HY-153489
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ISIS-CRPRx
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Antisense Oligonucleotides
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ISIS 329993 (ISIS-CRPRx) is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis
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- HY-160043
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Aptamers
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AL6 aptamer sodium is a short-chain nucleic acid aptamer chemically synthesized in vitro. AL6 aptamer sodium specifically targets Angiopoietin (Ang) for the specific detection of Ang. The AL6 aptamer binds to Ang, causing the rotational motion of the fluorophore on the AL6 aptamer to become slower. The concentration of Ang in the test solution can be quantified by detecting the anisotropy of AL6 aptamer/Ang .
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