800CW acid 

800CW acid is an orally active near-infrared (NIR) dye (excitation/emission 774/789 nm). 800CW acid can be used for intestinal permeability testing. 800CW acid can be used for in vivo imaging studies^[1][2].

800CW acid (2-6 mg/kg in the DSS colitis model, 6 mg/kg or 120 μg/mouse in the anti-CD40 colitis model, and 1 mg/kg in the cynomolgus macaque model; for DSS colitis and cynomolgus macaques: p.o.) can sensitively detect changes in intestinal permeability and distinguish between diseased and normal groups in the C57BL/6 mouse DSS colitis model, the SCID mouse anti-CD40 colitis model, and the cynomolgus macaque non-human primate model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1091.11

C₄₆H₅₀N₂Na₄O₁₅S₄

1088919-86-1

Solid

Green to dark green

O=C(CCCCCN1C2=CC=C(S(=O)(O[Na])=O)C=C2C(C)(C)/C1=C/C=C3C(OC4=CC=C(S(=O)(O[Na])=O)C=C4)=C(CCC\3)/C=C/C5=[N+](CCCCS(=O)(O[Na])=O)C6=C(C5(C)C)C=C(S(=O)([O-])=O)C=C6)O[Na]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Li Y, et al. Monitoring Tumor Targeting and Treatment Effects of IRDye 800CW and GX1-Conjugated Polylactic Acid Nanoparticles Encapsulating Endostar on Glioma by Optical Molecular Imaging. Mol Imaging. 2015;14:356-65.  [Content Brief]

  [2]. Zhang L, et al. Near infrared readouts offer sensitive and rapid assessments of intestinal permeability and disease severity in inflammatory bowel disease models. Sci Rep. 2020 Mar 13;10(1):4696.  [Content Brief]