L-Amoxicillin-d₄ sodium 

L-Amoxicillin-d₄ sodium is the deuterium labeled L-Amoxicillin (HY-129836). L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

391.41

C₁₆H₁₄D₄N₃NaO₅S

26889-93-0

O=C1[C@H]([C@@]2(N1[C@H](C(C)(S2)C)C(O[Na])=O)[H])NC([C@H](C3=C(C([2H])=C(C([2H])=C3[2H])O)[2H])N)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bellur Atici E, et al. Development and validation of stability indicating HPLC methods for related substances and assay analyses of amoxicillin and potassium clavulanate mixtures. J Pharm Biomed Anal. 2017 Mar 20;136:1-9.