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5-Amino-2-methoxyphenol is a phenolic regioisomer. 5-Amino-2-methoxyphenol produces dose-dependent antinociception in the mouse formalin test, with its second-phase effect being mechanistically dependent on both FAAH and TRPV1. 5-Amino-2-methoxyphenol can be used for antinociception research.

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5-Amino-2-methoxyphenol

5-Amino-2-methoxyphenol Chemical Structure

CAS No. : 1687-53-2

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5-Amino-2-methoxyphenol Related Antibodies

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Description

5-Amino-2-methoxyphenol is a phenolic regioisomer. 5-Amino-2-methoxyphenol produces dose-dependent antinociception in the mouse formalin test, with its second-phase effect being mechanistically dependent on both FAAH and TRPV1. 5-Amino-2-methoxyphenol can be used for antinociception research[1].

In Vitro

5-Amino-2-methoxyphenol (compound 2) is conjugated by FAAH in greater amounts, albeit less efficiently and in lesser amounts than 4-Aminopyridine (HY-B0604) in brain homogenate from FAAH+/+ mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-Amino-2-methoxyphenol Related Antibodies
In Vivo

5-Amino-2-methoxyphenol (25-100 mg/kg, i.p., single dose) dose-dependently produces antinociception in the mouse formalin test, with its second-phase effect being mechanistically dependent on both FAAH and TRPV1[1].
5-Amino-2-methoxyphenol (300 mg/kg, i.p., single dose) results in no significant liver injury, as indicated by serum levels of ALT and the ALT/AST ratio[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (8 weeks old)[1]
Dosage: 25, 50, 75 and 100 mg/kg
Administration: i.p., single dose
Result: Produces dose-dependent antinociception in both phases of the formalin test.
Its antinociceptive effect was inhibited by FAAH inhibitor URB937 (HY-116477) and TRPV1 antagonist Capsazepine (HY-15640) during the second, but not the first , phase of the formalin test at 50 mg/kg dose.
Did not affect locomotor activity in mice at 75 mg/kg.
Molecular Weight

139.15

Formula

C7H9NO2
CAS No.
SMILES

OC1=CC(N)=CC=C1OC
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Purity & Documentation
References
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5-Amino-2-methoxyphenol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Amino-2-methoxyphenol1687-53-2OthersAntinociceptionmouse formalin testFAAHTRPV1antinociceptionInhibitorinhibitorinhibit

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