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Results for "

human fibroblast

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (2) AMPK (1) Amylases (1) Anaplastic lymphoma kinase (ALK) (1) Angiotensin Receptor (5) Antibiotic (3) AP-1 (1) Apoptosis (15) Autophagy (2) Bacterial (16) Bcl-2 Family (2) Biochemical Assay Reagents (7) Bradykinin Receptor (4) Calcium Channel (2) Caspase (1) CDK (1) Cholinesterase (ChE) (1) Collagen (2) COX (1) Cytochrome P450 (3) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (10) Drug Intermediate (1) Drug Metabolite (1) Dynamin (2) EGFR (1) Endogenous Metabolite (13) Endonuclease (1) ERK (3) Estrogen Receptor/ERR (4) FAK (1) Ferroptosis (8) Fungal (2) Glutathione Peroxidase (2) Glycosidase (1) HBV (2) HDAC (2) Heme Oxygenase (HO) (2) HIF/HIF Prolyl-Hydroxylase (1) HPPD (2) HSV (1) IGF-1R (1) Indoleamine 2,3-Dioxygenase (IDO) (2) Integrin (1) Interleukin Related (2) Isotope-Labeled Compounds (3) Keap1-Nrf2 (3) MMP (6) Monoamine Oxidase (2) mRNA (27) mTOR (1) Na+/H+ Exchanger (NHE) (2) Oct3/4 (1) Orthopoxvirus (1) P2Y Receptor (1) p38 MAPK (1) Parasite (6) PGE synthase (1) Phosphodiesterase (PDE) (3) PI3K (2) Pim (1) PPAR (2) Protease Activated Receptor (PAR) (1) Ras (3) Reactive Oxygen Species (ROS) (13) Reference Standards (11) RET (1) TET Protein (1) TGF-β Receptor (2) Thymidylate Synthase (3) Transmembrane Glycoprotein (1) VD/VDR (2) β-glucuronidase (1)
By Research Areas:	Cancer (62) Cardiovascular Disease (21) Endocrinology (5) Infection (25) Inflammation/Immunology (27) Metabolic Disease (21) Neurological Disease (22)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	mRNA (27)

152

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

100

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: FAP FGFR Human leukocyte immunoglobulin (Ig)-like receptors (LILR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108999A

Crisnatol 1 Publications Verification BWA770U	DNA/RNA Synthesis	Cancer
Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts .

HY-113365

Cholestenone 4-Cholesten-3-one	Endogenous Metabolite	Infection Metabolic Disease
Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice .

HY-N1326

Santamarine Santamarin; Balchanin	Keap1-Nrf2	Inflammation/Immunology
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities .

HY-108036B

Pro-xylane Hydroxypropyl tetrahydropyrantriol	Biochemical Assay Reagents	Metabolic Disease
Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a bioactive C-glycoside that targets the biosynthesis pathway of glycosaminoglycans/mucopolysaccharides (GAGs) in the skin matrix and can be absorbed transdermally. Pro-xylane stimulates the biosynthesis of GAGs in fibroblasts, enhances the structural stability of the skin extracellular matrix, improves skin elasticity and moisturizing ability, and delays wrinkle formation. Pro-xylane can effectively promote the synthesis of collagen fibers and hyaluronic acid in the dermis. Pro-xylane is used in the field of anti-aging cosmetics to improve skin hydration and elasticity. Pro-xylane is eco-friendly and biodegradable .

HY-108999

Crisnatol mesylate BWA770U mesylate	DNA/RNA Synthesis	Cancer
Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts .

HY-108999AR

Crisnatol (Standard)	DNA/RNA Synthesis	Cancer
Crisnatol (Standard) is the analytical standard of Crisnatol. This product is intended for research and analytical applications. Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts .

HY-172745

Conglobatin B1	Others	Cancer
Conglobatin B1 is a compound that can be isolated from Australian Streptomyces MST-91080. Conglobatin B1 is cytotoxic to the NS-1 myeloma cell line with an IC₅₀ of 0.084 μg/mL, but has low toxicity to NFF human fibroblasts. Conglobatin B1 can be used in the study of cancer .

HY-162721

Anticancer agent 242	Others	Cancer
Anticancer agent 242 (7) possesses anticancer activity in A2780 (IC₅₀ = 0.24 μM, ovarian adenocarcinoma), A2780cis (IC₅₀ = 0.45 μM, resistant derivative of A2780), CCD18Co (IC₅₀ = 0.59 μM, non-malignant human fibroblasts), A549 (IC₅₀ = 0.32 μM, lung carcinoma), HT29 (IC₅₀ = 0.26 μM, colorectal adenocarcinoma), and MCF7 (IC₅₀ = 0.55 μM, breast adenocarcinoma) .

HY-W207699

MAO-B-IN-46	Monoamine Oxidase Amylases	Neurological Disease Metabolic Disease Inflammation/Immunology
MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC₅₀: 26.8 nM), with weak activity against hMAO-A (IC₅₀: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC₅₀: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC₅₀ values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance .

HY-174711

Human FGF10 mRNA	mRNA	Cancer
Human FGF10 mRNA encodes the human fibroblast growth factor 10 (FGF10) protein, a member of the fibroblast growth factor (FGF) family. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7.

HY-108036

Pro-xylane (30% in water) Hydroxypropyl tetrahydropyrantriol (30% in water)	Biochemical Assay Reagents	Metabolic Disease
Pro-xylane (30% in water) (Hydroxypropyl tetrahydropyrantriol) is a bioactive C-glycoside that targets the biosynthesis pathway of glycosaminoglycans/mucopolysaccharides (GAGs) in the skin matrix and can be absorbed transdermally. Pro-xylane (30% in water) stimulates the biosynthesis of GAGs in fibroblasts, enhances the structural stability of the skin extracellular matrix, improves skin elasticity and moisturizing ability, and delays wrinkle formation. Pro-xylane (30% in water) can effectively promote the synthesis of collagen fibers and hyaluronic acid in the dermis. Pro-xylane (30% in water) is used in the field of anti-aging cosmetics to improve skin hydration and elasticity. Pro-xylane (30% in water) is eco-friendly and biodegradable .

HY-174698

Human FGF23 mRNA	mRNA	Cancer
Human FGF23 mRNA encodes the human fibroblast growth factor 23 (FGF23) protein, a member of the fibroblast growth factor (FGF) family. FGF23 regulates phosphate homeostasis and transport in the kidney.

HY-174686

Human FGFRL1 mRNA	mRNA	Cancer
Human FGFRL1 mRNA encodes the human fibroblast growth factor receptor like 1 (FGFRL1) protein, a member of the fibroblast growth factor receptor (FGFR) family. The extracellular portion of FGFRL1 protein can interact with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

HY-174689

Human FGFR2 mRNA	mRNA	Cancer
Human FGFR2 mRNA encodes the human fibroblast growth factor receptor 2 (FGFR2) protein, a member of the fibroblast growth factor receptor (FGFR) family. The extracellular portion of FGFR2 protein can interact with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

HY-174690

Human FGFR1 mRNA	mRNA	Cancer
Human FGFR1 mRNA encodes the human fibroblast growth factor receptor 1 (FGFR1) protein, a member of the fibroblast growth factor receptor (FGFR) family. The extracellular portion of FGFR1 protein can interact with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

HY-174688

Human FGFR3 mRNA	mRNA	Cancer
Human FGFR3 mRNA encodes the human fibroblast growth factor receptor 3 (FGFR3) protein, a member of the fibroblast growth factor receptor (FGFR) family. The extracellular portion of FGFR3 protein can interact with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

HY-174707

Human FGF14 mRNA	mRNA	Neurological Disease
Human FGF14 mRNA encodes the human fibroblast growth factor 14 (FGF14) protein, a member of the fibroblast growth factor (FGF) family. FGF14 probably involves in nervous system development and function.

HY-174710

Human FGF11 mRNA	mRNA	Neurological Disease
Human FGF11 mRNA encodes the human fibroblast growth factor 11 (FGF11) protein, a member of the fibroblast growth factor (FGF) family. FGF11 probably involves in nervous system development and function.

HY-174701

Human FGF20 mRNA	mRNA	Neurological Disease
Human FGF20 mRNA encodes the human fibroblast growth factor 20 (FGF20) protein, a member of the fibroblast growth factor (FGF) family. FGF20 may regulate central nervous system development and function.

HY-174695

Human FGF5 mRNA	mRNA	Cancer
Human FGF5 mRNA encodes the human fibroblast growth factor 5 (FGF5) protein, a member of the fibroblast growth factor (FGF) family. FGF5 may play an important role in the regulation of cell proliferation and cell differentiation.

HY-174708

Human FGF13 mRNA	mRNA	Neurological Disease
Human FGF13 mRNA encodes the human fibroblast growth factor 13 (FGF13) protein, a member of the fibroblast growth factor (FGF) family. FGF13 plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.

HY-174696

Human FGF4 mRNA	mRNA	Cancer
Human FGF4 mRNA encodes the human fibroblast growth factor 4 (FGF4) protein, a member of the fibroblast growth factor (FGF) family. FGF4 may play an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.

HY-174697

Human FGF3 mRNA	mRNA	Cancer
Human FGF3 mRNA encodes the human fibroblast growth factor 3 (FGF3) protein, a member of the fibroblast growth factor (FGF) family. FGF3 may play an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.

HY-174709

Human FGF12 mRNA	mRNA	Neurological Disease
Human FGF12 mRNA encodes the human fibroblast growth factor 12 (FGF12) protein, a member of the fibroblast growth factor (FGF) family. FGF12 probably involves in nervous system development and function, and the positive regulation of voltage-gated sodium channel activity.

HY-174700

Human FGF21 mRNA	mRNA	Cancer
Human FGF21 mRNA encodes the human fibroblast growth factor 21 (FGF21) protein, a member of the fibroblast growth factor (FGF) family. FGF21 is a secreted endocrine factor that functions as a major metabolic regulator. It stimulates the uptake of glucose in adipose tissue.

HY-174702

Human FGF2 mRNA	mRNA	Neurological Disease
Human FGF2 mRNA encodes the human fibroblast growth factor 2 (FGF2) protein, a member of the fibroblast growth factor (FGF) family. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth.

HY-137630

Sp-8-pCPT-2'-O-Me-cAMPS	Ras	Metabolic Disease
Sp-8-pCPT-2'-O-Me-cAMPS is an activator of EPAC. Sp-8-pCPT-2'-O-Me-cAMPS can be used in endocrine metabolism related research .

HY-174694

Human FGF6 mRNA	mRNA	Cancer
Human FGF6 mRNA encodes the human fibroblast growth factor 6 (FGF6) protein, a member of the fibroblast growth factor (FGF) family. FGF6 may play an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is also required for normal muscle regeneration.

HY-174704

Human FGF18 mRNA	mRNA	Cancer
Human FGF18 mRNA encodes the human fibroblast growth factor 18 (FGF18) protein, a member of the fibroblast growth factor (FGF) family. FGF18 probably plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. It is also required for normal ossification and bone development.

HY-174705

Human FGF17 mRNA	mRNA	Cancer
Human FGF17 mRNA encodes the human fibroblast growth factor 17 (FGF17) protein, a member of the fibroblast growth factor (FGF) family. FGF17 probably plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. It is also required for normal brain development.

HY-174706

Human FGF16 mRNA	mRNA	Cardiovascular Disease
Human FGF16 mRNA encodes the human fibroblast growth factor 16 (FGF16) protein, a member of the fibroblast growth factor (FGF) family. FGF16 probably plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. It is also required for normal cardiomyocyte proliferation and heart development.

HY-174699

Human FGF22 mRNA	mRNA	Cancer
Human FGF22 mRNA encodes the human fibroblast growth factor 22 (FGF22) protein, a member of the fibroblast growth factor (FGF) family. FGF22 plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. It also can stimulate cell proliferation (in vitro) and may be involved in hair development.

HY-174692

Human FGF8 mRNA	mRNA	Cancer
Human FGF8 mRNA encodes the human fibroblast growth factor 8 (FGF8) protein, a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

HY-174703

Human FGF19 mRNA	mRNA	Cancer
Human FGF19 mRNA encodes the human fibroblast growth factor 19 (FGF19) protein, a member of the fibroblast growth factor (FGF) family. FGF19 probably involves in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades.

HY-174693

Human FGF7 mRNA	mRNA	Cancer
Human FGF7 mRNA encodes the human fibroblast growth factor 7 (FGF7) protein, a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

HY-174712

Human FGF1 mRNA	mRNA	Cancer
Human FGF1 mRNA encodes the human Fibroblast growth factor 1 (FGF1) protein, a member of fibroblast growth factor (FGF) family. FGF1 functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It also acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis.

HY-174691

Human FGF9 mRNA	mRNA	Cancer
Human FGF9 mRNA encodes the human fibroblast growth factor 9 (FGF9) protein, a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

HY-174687

Human FGFR4 mRNA	mRNA	Cancer
Human FGFR4 mRNA encodes the human fibroblast growth factor receptor 4 (FGFR4) protein, a tyrosine kinase and cell surface receptor for fibroblast growth factors. FGFR4 is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis.

HY-118518

Ronipamil	Calcium Channel	Cardiovascular Disease Cancer
Ronipamil is a calcium ion antagonist. Ronipamil increases the specific binding and internalization of human ¹²⁵I-LDL in human skin fibroblasts (HSF) and the human hepatoma cell line Hep G2 .

HY-174311

GT-02216	Glycosidase	Neurological Disease
GT-02216 can bind to GCase allosterically and enhance its activity. GT-02216 enhances the activity of GCase in primary human fibroblasts. GT-02216 reduces the Tau accumulation in mutant GBA1 fibroblasts. GT-02216 protects the hippocampal primary neurons challenged with Tau oligomer in rat model .

HY-W020044

DL-alpha-Tocopherol 5+ Cited Publications DL-α-Tocopherol	Ferroptosis DNA/RNA Synthesis Apoptosis	Cancer
DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-P4836

LL-37 FK-13	Parasite	Infection
LL-37 FK-13 is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 exhibits slight hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .

HY-122274

MMV666693	Parasite	Infection
MMV666693 is a translation inhibitor specific for Plasmodium falciparum. MMV666693 has low cytotoxicity in human fibroblasts (IC₅₀>32 µM) and can be used in the development of antimalarial drugs .

HY-114297

Zymosterol 2 Publications Verification	Endogenous Metabolite	Others
Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell .

HY-152086

DRP1i27	Dynamin	Cardiovascular Disease
DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .

HY-P3544

Lys-[Hyp3]-Bradykinin	Bradykinin Receptor	Inflammation/Immunology
Lys-[Hyp3]-Bradykinin a Bradykinin (HY-P0206) agonist. Lys-[Hyp3]-Bradykinin is a kinin, it can be isolated from human urine. Lys-[Hyp3]-Bradykinin can be used for the research of inflammation .

HY-152086A

DRP1i27 dihydrochloride	Dynamin	Cardiovascular Disease
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .

HY-113365R

Cholestenone (Standard) 4-Cholesten-3-one (Standard)	Reference Standards Endogenous Metabolite	Infection Metabolic Disease
Clebopride (malate) (Standard) is the analytical standard of Clebopride (malate). This product is intended for research and analytical applications. Clebopride malate is a dopamine antagonist used in the study of functional gastrointestinal disorders.

HY-N12653

Exserohilone (-)-Exserohilone	Reactive Oxygen Species (ROS)	Metabolic Disease
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

HY-W745164

3,3′-Bisdemethylpinoresinol	MMP	Inflammation/Immunology
3,3′-Bisdemethylpinoresinol, lignin, is a nature product and has MMP-1 inhibitory activity in UVA-irradiated human dermal fibroblasts. 3,3′-Bisdemethylpinoresinol can be isolated from the seeds of Morinda citrifolia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113365

Cholestenone 4-Cholesten-3-one	Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice .

HY-N1326

Santamarine Santamarin; Balchanin	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Magnoliaceae Plants Inflammation/Immunology Disease Research Fields Magnolia grandiflora L.	Keap1-Nrf2
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities .

HY-W020044

DL-alpha-Tocopherol 5+ Cited Publications DL-α-Tocopherol	Duchesnea indica (Andr.) Focke Monophenols Classification of Application Fields Source classification Rosaceae Other Diseases Phenols Plants Disease Research Fields	Ferroptosis DNA/RNA Synthesis Apoptosis
DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-114297

Zymosterol 2 Publications Verification	Source classification Endogenous metabolite Steroids	Endogenous Metabolite
Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell .

HY-W745164

3,3′-Bisdemethylpinoresinol	Source classification Lignans Rubiaceae Morinda citrifolia Linn. Phenylpropanoids Plants	MMP
3,3′-Bisdemethylpinoresinol, lignin, is a nature product and has MMP-1 inhibitory activity in UVA-irradiated human dermal fibroblasts. 3,3′-Bisdemethylpinoresinol can be isolated from the seeds of Morinda citrifolia .

HY-N13286

Glycozolidal	Alkaloids Glycosmis arborea (Retz.) Corrêa Source classification Rutaceae Carbazole Alkaloids Plants	Bacterial
Glycozolidal (compound 12) is a carbazole alkaloid with antibacterial activity against P. gingivalis. Glycozolidal is cytotoxic against human gingival fibroblasts (HGFs) and monocytes (U937) in vitro with IC₅₀ values of 120.86 µg/mL and 97.74 µg/mL, respectively .

HY-172745

Conglobatin B1	Natural Products Microorganisms Source classification	Others
Conglobatin B1 is a compound that can be isolated from Australian Streptomyces MST-91080. Conglobatin B1 is cytotoxic to the NS-1 myeloma cell line with an IC₅₀ of 0.084 μg/mL, but has low toxicity to NFF human fibroblasts. Conglobatin B1 can be used in the study of cancer .

HY-113365R

Cholestenone (Standard) 4-Cholesten-3-one (Standard)	Microorganisms Source classification Endogenous metabolite Steroids	Reference Standards Endogenous Metabolite
Clebopride (malate) (Standard) is the analytical standard of Clebopride (malate). This product is intended for research and analytical applications. Clebopride malate is a dopamine antagonist used in the study of functional gastrointestinal disorders.

HY-N12653

Exserohilone (-)-Exserohilone	Microorganisms Antibiotics Source classification Other Antibiotics	Reactive Oxygen Species (ROS)
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

HY-N5123

α-L-Rhamnose	Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides Monosaccharides	Others
α-L-Rhamnose is a terminal residue of steviol glycosides Dulcoside A and Dulcoside B. α-L-Rhamnose recognizing lectin site of human dermal fibroblasts functions as a signal transducer: modulation of Ca ²⁺ fluxes and gene expression .

HY-167835A

Tembetarine chloride	Alkaloids Other Alkaloids Cymbopetalum brasiliense (Vell.) Benth. ex Baill. Source classification Plants Annonaceae	Bacterial
Tembetarine chloride is a alkaloid that can be isolated from Tinospora cordifolia that exhibits antibacterial activity. Tembetarine chloride exhibits weak cytotoxicity against mouse fibroblasts (L929) and human embryonic kidney cells (HEK293) with IC₅₀ of 1245.33 μg/mL and 1642.81 μg/mL, respectively .

HY-W020044R

DL-alpha-Tocopherol (Standard) 5+ Cited Publications DL-α-Tocopherol (Standard)	Duchesnea indica (Andr.) Focke Classification of Application Fields Source classification Rosaceae Other Diseases Phenols Plants Disease Research Fields	Reference Standards Ferroptosis DNA/RNA Synthesis Apoptosis
DL-alpha-Tocopherol (Standard) is the analytical standard of DL-alpha-Tocopherol. This product is intended for research and analytical applications. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-N4298

Epitheaflagallin 3-O-gallate	Classification of Application Fields Source classification Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Inflammation/Immunology Theaceae	MMP
Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts .

HY-B1192

Estradiol benzoate 10+ Cited Publications β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Classification of Application Fields Disease Research Fields Cancer	Estrogen Receptor/ERR HBV Bcl-2 Family
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-N15479

Nanangenine F	Microorganisms Terpenoids Sesquiterpenes Source classification	Bacterial
Nanangenine F is a drimane sesquiterpenoid with weak antibacterial and anticancer activities. Nanangenine F inhibits Bacillus subtilis (ATCC 6633) with an IC₅₀ of 78 µg/mL. Nanangenine F inhibits NS-1, DU-145, MCF-7 and human fibroblast NFF cells with IC₅₀s of 49 µg/mL, 95 µg/mL, 49 µg/mL, and 84 µg/mL, respectively .

HY-125918

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Microorganisms Antibiotics Source classification	Apoptosis Antibiotic
Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death ..

HY-119358

Traumatic Acid 2 Publications Verification	Microorganisms Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Plants Phytohormone Phaseolus vulgaris Linn. Inflammation/Immunology Disease Research Fields Cytokinin Agricultural Research	Reactive Oxygen Species (ROS) Apoptosis
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis .

HY-N1190

DL-Syringaresinol (±)-Syringaresinol	Source classification Lignans Phenylpropanoids Plants Lauraceae Lindera akoensis Hay.	p38 MAPK AP-1 Bacterial
DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing MAPK/AP-1 signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv .

HY-119609

Ilicicolin C	Microorganisms Antibiotics Source classification	Bacterial Cholinesterase (ChE) β-glucuronidase
Ilicicolin C exhibits antibacterial activity against Pseudomonas syringae with IC₅₀ of 28.5 µg/mL. Ilicicolin C exhibits weak inhibitory activities against acetylcholinesterase (AChE) and β-glucuronidase with IC₅₀ of 30-43 µg/mL. Ilicicolin C exhibits weak cytoxicity in human lung fibroblasts with IC₅₀ of 64-120 µg/mL. Ilicicolin C affects seed germination and root tip growth of lettuce .

HY-12688

Succinyl phosphonate	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species (ROS)
Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts . Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner . Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ .

HY-N16437

Panowamycin A	Natural Products Microorganisms Source classification	Parasite
Panowamycin A is an isochroman compound that can be produced by Streptomyces sp. K07-0010. Panowamycin A exhibits antitrypanosomal activity against the Trypanosoma brucei brucei GUTat 3.1 strain (IC₅₀: 0.40 μg/mL). Panowamycin A shows weak cytotoxicity towards human fetal lung fibroblast MRC-5 cells (IC₅₀: 2.95 μg/mL). Panowamycin A can be used for research in the field of antitrypanosomal studies .

HY-12688A

Succinyl phosphonate trisodium salt 10+ Cited Publications	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Reactive Oxygen Species (ROS)
Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts . Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner . Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ .

HY-N16437A

Panowamycin B	Natural Products Microorganisms Source classification	Parasite
Panowamycin B is an isochroman compound that can be produced by Streptomyces sp. K07-0010. Panowamycin B exhibits antitrypanosomal activity against the Trypanosoma brucei brucei GUTat 3.1 strain (IC₅₀: 3.30 μg/mL). Panowamycin B shows weak cytotoxicity towards human fetal lung fibroblast MRC-5 cells (IC₅₀: 13 μg/mL). Panowamycin B can be used for research in the field of antitrypanosomal studies .

HY-D0835

Hydroxylapatite (25-45 μm) Hydroxyapatite (25-45 μm)	Natural Products Animals Classification of Application Fields Source classification Other Diseases Disease Research Fields	Others
Hydroxylapatite (Hydroxyapatite) (25-45 μm) is a natural form of calcium phosphate and is the main mineral component of bones and teeth. Hydroxylapatite (25-45 μm) can stimulate the expression and secretion of collagen in primary human dermal fibroblasts. Hydroxylapatite (25-45 μm) has good biocompatibility, bioactivity, and bone conductivity, making it suitable for targeted drug or nucleic acid delivery. Hydroxylapatite (25-45 μm) can be used in research on osteoarthritis, gout, and atherosclerosis .

HY-N15343

Albiducin A	Microorganisms Source classification Phenols Polyphenols	Antibiotic Bacterial Fungal
Albiducin A is an antibiotic found in Hymenoscyphus albidus, exhibiting antibacterial and anticancer activities. The MIC range of Albiducin A against bacteria and fungi is 16.7-66.7 mg/mL. Its IC₅₀ values for mouse fibroblast cell line (L929) and human cervical carcinoma cell line (KB3-1) are 6.1 and 2.7 μg/mL, respectively. Albiducin A holds promise for research in the fields of infection and cancer diseases .

HY-119358R

Traumatic Acid (Standard)	Microorganisms Leguminosae Ketones, Aldehydes, Acids Source classification Plants Phaseolus vulgaris Linn.	Reference Standards Reactive Oxygen Species (ROS) Apoptosis
Traumatic Acid (Standard) is the analytical standard of Traumatic Acid. This product is intended for research and analytical applications. Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis[1][2].

HY-P0063

Copper tripeptide 1 Publications Verification GHK-Cu	Natural Products Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Biochemical Assay Reagents
Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, Copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration .

HY-13948

Angiotensin II human Maximum Cited Publications 186 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Angiotensin Receptor Apoptosis
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-N2038

3,5,6,7,8,3',4'-Heptemthoxyflavone	Flavonols Flavonoids Rutaceae Plants Citrus reticulata Blanco	Phosphodiesterase (PDE)
3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

HY-B1777A

Spermine tetrahydrochloride 4 Publications Verification	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .

HY-B1777

Spermine 4 Publications Verification NSC 268508; Neuridine	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro .

HY-B1777AR

Spermine tetrahydrochloride (Standard)	Natural Products Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Spermine (tetrahydrochloride) (Standard) is the analytical standard of Spermine (tetrahydrochloride). This product is intended for research and analytical applications. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .

HY-N2038R

3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone (Standard)	Flavonols Flavonoids Rutaceae Plants Citrus reticulata Blanco	Reference Standards Phosphodiesterase (PDE)
3,5,6,7,8,3',4'-Heptemthoxyflavone (Standard) is the analytical standard of 3,5,6,7,8,3',4'-Heptemthoxyflavone (HY-N2038). This product is intended for research and analytical applications. 3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

HY-N0353R

Curdione (Standard) (+)-Curdione (Standard)	Terpenoids Sesquiterpenes Source classification Curcuma phaeocaulis Valeton Plants Zingiberaceae	Reference Standards Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)
Curdione (Standard) is the analytical standard of Curdione. This product is intended for research and analytical applications. Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

HY-N0353

Curdione 1 Publications Verification (+)-Curdione	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Other Diseases Curcuma phaeocaulis Valeton Plants Disease Research Fields Zingiberaceae	Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)
Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

Cat. No.	Product Name	Chemical Structure

HY-B1777AS

Spermine-d8 tetrahydrochloride

Spermine-d₈ (tetrahydrochloride) is the deuterium labeled Spermine tetrahydrochloride. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .

HY-W020044S1

DL-alpha-Tocopherol-d9
DL-alpha-Tocopherol-d₉ is the deuterium labeled DL-alpha-Tocopherol . DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-W020044S

DL-alpha-Tocopherol-13C3
DL-alpha-Tocopherol- ¹³C₃ is the ¹³C-labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-W654296

Octocrylene-13C3

Octocrylene- ¹³C₃ is the ¹³C-labeled Octocrylene (HY-A0087). Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes .

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