Search Result

Results for "

complement protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Complement System (11) Akt (2) Apoptosis (1) Biochemical Assay Reagents (7) Caspase (1) Endogenous Metabolite (1) Liposome (1) mTOR (1) Small Interfering RNA (siRNA) (1) TGF-β Receptor (1) VEGFR (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Endocrinology (2) Infection (2) Inflammation/Immunology (8) Metabolic Disease (3) Neurological Disease (3)
Oligonucleotides:	mRNA (1) siRNA drugs (2) siRNAs (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Complement System

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99050

Sutimlimab	Complement System	Cardiovascular Disease Inflammation/Immunology
Sutimlimab is a humanized monoclonal IgG4 antibody. Sutimlimab inhibits complement protein component 1, s subcomponent (C1s). Sutimlimab blocks C3 and C4 activation. Sutimlimab can be used for the research of cold agglutinin disease and complement-mediated hemolytic uremic syndrome .

HY-P99365

Ravulizumab ALXN1210	Complement System	Metabolic Disease
Ravulizumab (ALXN1210) is a humanized monoclonal antibody that specifically binds with high affinity to the human complement protein C5. Ravulizumab can be used for the research of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and myasthenia gravis .

HY-145720A

Cemdisiran sodium ALN-CC5 sodium	Complement System	Others
Cemdisiran sodium is an N-acetylgalactosamine (GalNAc) conjugated siRNA for the research of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein.

HY-145720

Cemdisiran ALN-CC5	Small Interfering RNA (siRNA) Complement System	Others
Cemdisiran is an N-acetylgalactosamine (GalNAc) conjugated siRNA for the research of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein.

HY-P99638

Gefurulimab ALXN-1720	Complement System	Inflammation/Immunology
Gefurulimab (ALXN-1720) is a high-affinity antibody inhibitor targeting complement protein C5, which can specifically bind to C5 and inhibit its cleavage into C5a and C5b. Gefurulimab can block the activation of the terminal complement pathway and reduce inflammatory damage. Gefurulimab can effectively reduce the formation of membrane attack complex (MAC) and has good pharmacokinetic properties. Gefurulimab can be used to study kidney and autoimmune diseases related to abnormal activation of the complement system, such as IgA nephropathy, lupus nephritis, and myasthenia gravis .

HY-P99905

Efdamrofusp alfa	VEGFR	Cardiovascular Disease Neurological Disease
Efdamrofusp alfa is a bispecific fusion protein. Efdamrofusp alfa is capable of neutralizing both VEGF isoforms and C3b/C4b. Efdamrofusp alfa can be used for the research of neovascular age-related macular degeneration (nAMD) and other complement-related ocular conditions .

HY-P2969

Complement factor I	Endogenous Metabolite	Metabolic Disease
Complement factor I is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein (C4BP) or membrane cofactor protein (MCP/CD46) .

HY-P99767

Olendalizumab ALXN1007	Complement System	Infection
Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (K_i=60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be used for research of complement mediated disorder caused by corona virus .

HY-NP0194A

C1q Protein (Mouse)	Complement System	Inflammation/Immunology
C1q Protein (Mouse) is the subunit of the complement system. C1q Protein (Mouse) recognizes a variety of ligands, and is involved in maintaining immune system balance, promoting tissue repair, and defending against pathogens .

HY-P991067

Vensobafusp alfa KP-104	Complement System	Inflammation/Immunology
Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .

HY-153403

Activated A Subunit	Biochemical Assay Reagents	Others
Activated A Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy .

HY-P1823

C-Reactive Protein (CRP) (174-185)	Akt mTOR Caspase	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
C-Reactive Protein (CRP) is an anti-pneumococcal plasma protein that can serve as an inflammatory marker. C-Reactive protein can protect mice from pneumococcal infection by activating complement. C-Reactive protein can inhibit the activation of caspase-3/9 through the CD64/AKT/mTOR pathway, thereby promoting chemotherapy resistance in mice with tongue squamous cell carcinoma .

HY-153404

Activated C Subunit	Biochemical Assay Reagents	Others
Activated C Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy .

HY-153407

NCP2 Anchor	Others	Others
NCP2 Anchor can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 52 jumping. It can be used for research of muscular dystrophy .

HY-153406

Activated T Subunit	Biochemical Assay Reagents	Others
Activated T Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy .

HY-153405

Activated DPG Subunit	Biochemical Assay Reagents	Others
Activated DPG Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy .

HY-153402

Activated EG3 Tail	Biochemical Assay Reagents	Others
Activated EG3 Tail can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy .

HY-P1345

TLQP-21	Complement System	Neurological Disease Endocrinology
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent *G-protein-coupled receptor complement-3a receptor 1 (C3aR1)* agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca ²⁺. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions .

HY-P1345A

TLQP-21 TFA 1 Publications Verification	Complement System	Neurological Disease Endocrinology
TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent *G-protein-coupled receptor complement-3a receptor1 (C3aR1)* agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca ²⁺. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions .

HY-128342

Complement C5-IN-1	Complement System	Inflammation/Immunology
Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC₅₀ of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .

HY-A0183

Phosphatidylserine Phospholipids, phosphatidylserines; Serine glycerophosphatides	Akt TGF-β Receptor	Inflammation/Immunology
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses .

HY-153230

Firefly luciferase circRNA-LNP	Liposome Biochemical Assay Reagents	Others
Firefly luciferase circRNA-LNP is a lipid nanoparticle (LNP) containing Firefly luciferase circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. Luciferase is commonly used as a bioluminescent reporter gene for gene regulation and function studies. Firefly Luciferase circRNA will express firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Common luciferase are firefly luciferase and sea kidney luciferase .

HY-P9976

Isatuximab 1 Publications Verification	Apoptosis	Cancer
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

HY-153229

Firefly luciferase mRNA-LNP	Biochemical Assay Reagents	Others
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

Cat. No.	Product Name

HY-L207

Mass Spectrometry Human Endogenous Metabolite Library	643 compounds
Metabolomics is the large-scale study of cellular metabolic complement, with proven utility in both basic and applied studies of plants, microorganisms, and mammals. As an important tool for the study of complex biological systems, metabolomics monitors the complex molecular networks that exist in the natural flow of information from genes to mRNA and proteins to organisms. The metabolome is composed of biomolecules that most closely resemble the phenotype of an organism, and changes in its composition can easily lead to the production of diseases. Therefore, metabolomics has received much attention in drug target discovery, drug response and translational research of disease mechanisms. Mass spectrometry-based metabolomics methods can simultaneously detect and quantify thousands of metabolite signatures, thereby characterizing the pathophysiological mechanisms of various biomedical symptoms. MCE can provide 643 mass spectrometry human endogenous metabolites that can be used for metabolite identification and quantification, functional cell detection and phenotypic screening of mass spectrometry.

Mass Spectrometry Human Endogenous Metabolite Library

643 compounds

Metabolomics is the large-scale study of cellular metabolic complement, with proven utility in both basic and applied studies of plants, microorganisms, and mammals. As an important tool for the study of complex biological systems, metabolomics monitors the complex molecular networks that exist in the natural flow of information from genes to mRNA and proteins to organisms. The metabolome is composed of biomolecules that most closely resemble the phenotype of an organism, and changes in its composition can easily lead to the production of diseases. Therefore, metabolomics has received much attention in drug target discovery, drug response and translational research of disease mechanisms. Mass spectrometry-based metabolomics methods can simultaneously detect and quantify thousands of metabolite signatures, thereby characterizing the pathophysiological mechanisms of various biomedical symptoms.

MCE can provide 643 mass spectrometry human endogenous metabolites that can be used for metabolite identification and quantification, functional cell detection and phenotypic screening of mass spectrometry.

HY-L001P

Bioactive Compound Library Plus	27,015 compounds
Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. MCE owns a unique collection of 27,015 compounds with confirmed biological activities and clear targets. These compounds include natural products, innovative compounds, approved compounds, and clinical compounds. This library is a useful tool for signal pathway research, drug discovery and drug repurposing, etc. Bioactive Compound Library Plus, with more powerful screening capability, further complements Bioactive Compound Library (HY-L001) by adding some compounds with low solubility or solution stability (Part B) and some novel, rare or exclusive compounds (Part C) to this library. Overall, bioactive compound library plus (HY-L001P) includes tree parts: Part A, Part B and Part C. Compounds in Part A are equal to the products in HY-L001, which can be supplied in solution or solid form. Compounds in Part B and C are only supplied in solid form.

Bioactive Compound Library Plus

27,015 compounds

Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype.

MCE owns a unique collection of 27,015 compounds with confirmed biological activities and clear targets. These compounds include natural products, innovative compounds, approved compounds, and clinical compounds. This library is a useful tool for signal pathway research, drug discovery and drug repurposing, etc.

Bioactive Compound Library Plus, with more powerful screening capability, further complements Bioactive Compound Library (HY-L001) by adding some compounds with low solubility or solution stability (Part B) and some novel, rare or exclusive compounds (Part C) to this library. Overall, bioactive compound library plus (HY-L001P) includes tree parts: Part A, Part B and Part C. Compounds in Part A are equal to the products in HY-L001, which can be supplied in solution or solid form. Compounds in Part B and C are only supplied in solid form.

HY-L036P

Covalent Screening Library Plus	5,778 compounds
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE covalent inhibitor library contains 5,778 small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc. MCE Covalent inhibitor Library plus, with more powerful screening capability, further complement Covalent inhibitor Library (HY-L036) by adding some fragment compounds with covalent warheads.

Covalent Screening Library Plus

5,778 compounds

Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.

MCE covalent inhibitor library contains 5,778 small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

MCE Covalent inhibitor Library plus, with more powerful screening capability, further complement Covalent inhibitor Library (HY-L036) by adding some fragment compounds with covalent warheads.

Cat. No.	Product Name	Type

HY-NP004

Cobra Venom Factor CVF	Native Proteins
Cobra venom factor (CVF) is the complement-activating protein from cobra venom. CVF is a three-chain protein that functionally resembles C3b, the activated form of complement component C3. Cobra Venom Factor can be used for the research of the functions of complement in host defense and immune response as well as in the pathogenesis of diseases .

HY-153229

Firefly luciferase mRNA-LNP	Drug Delivery
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

Firefly luciferase mRNA-LNP

Drug Delivery

Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-NP0194A

C1q Protein (Mouse)	Native Proteins
C1q Protein (Mouse) is the subunit of the complement system. C1q Protein (Mouse) recognizes a variety of ligands, and is involved in maintaining immune system balance, promoting tissue repair, and defending against pathogens .

HY-153230

Firefly luciferase circRNA-LNP	Drug Delivery
Firefly luciferase circRNA-LNP is a lipid nanoparticle (LNP) containing Firefly luciferase circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. Luciferase is commonly used as a bioluminescent reporter gene for gene regulation and function studies. Firefly Luciferase circRNA will express firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Common luciferase are firefly luciferase and sea kidney luciferase .

Firefly luciferase circRNA-LNP

Drug Delivery

Firefly luciferase circRNA-LNP is a lipid nanoparticle (LNP) containing Firefly luciferase circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. Luciferase is commonly used as a bioluminescent reporter gene for gene regulation and function studies. Firefly Luciferase circRNA will express firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Common luciferase are firefly luciferase and sea kidney luciferase .

Cat. No.	Product Name	Target	Research Area

HY-P1823

C-Reactive Protein (CRP) (174-185)	Akt mTOR Caspase	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
C-Reactive Protein (CRP) is an anti-pneumococcal plasma protein that can serve as an inflammatory marker. C-Reactive protein can protect mice from pneumococcal infection by activating complement. C-Reactive protein can inhibit the activation of caspase-3/9 through the CD64/AKT/mTOR pathway, thereby promoting chemotherapy resistance in mice with tongue squamous cell carcinoma .

HY-P1345A

TLQP-21 TFA 1 Publications Verification	Complement System	Neurological Disease Endocrinology
TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent *G-protein-coupled receptor complement-3a receptor1 (C3aR1)* agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca ²⁺. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions .

HY-P10632

HiBiT tag	Peptides	Others
HiBiT tag is a complimentary peptide (VSGWRLFKKIS), with high affinity for LgBiT. HiBiT tag is fused to the Gβ subunit of the receptor. The complementation of LgBiT and HiBiT facilitates the stabilization of ETR and G protein. HiBiT is attached to a protein of interest (GFP) to quantify transport to the cytosol .

HY-P1345

TLQP-21	Complement System	Neurological Disease Endocrinology
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent *G-protein-coupled receptor complement-3a receptor 1 (C3aR1)* agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca ²⁺. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions .

Cat. No.	Product Name	Target	Research Area

HY-P99050

Sutimlimab	Complement System	Cardiovascular Disease Inflammation/Immunology
Sutimlimab is a humanized monoclonal IgG4 antibody. Sutimlimab inhibits complement protein component 1, s subcomponent (C1s). Sutimlimab blocks C3 and C4 activation. Sutimlimab can be used for the research of cold agglutinin disease and complement-mediated hemolytic uremic syndrome .

HY-P99365

Ravulizumab ALXN1210	Complement System	Metabolic Disease
Ravulizumab (ALXN1210) is a humanized monoclonal antibody that specifically binds with high affinity to the human complement protein C5. Ravulizumab can be used for the research of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and myasthenia gravis .

HY-P99638

Gefurulimab ALXN-1720	Complement System	Inflammation/Immunology
Gefurulimab (ALXN-1720) is a high-affinity antibody inhibitor targeting complement protein C5, which can specifically bind to C5 and inhibit its cleavage into C5a and C5b. Gefurulimab can block the activation of the terminal complement pathway and reduce inflammatory damage. Gefurulimab can effectively reduce the formation of membrane attack complex (MAC) and has good pharmacokinetic properties. Gefurulimab can be used to study kidney and autoimmune diseases related to abnormal activation of the complement system, such as IgA nephropathy, lupus nephritis, and myasthenia gravis .

HY-P9976

Isatuximab 1 Publications Verification	Apoptosis	Cancer
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

HY-P99905

Efdamrofusp alfa	VEGFR	Cardiovascular Disease Neurological Disease
Efdamrofusp alfa is a bispecific fusion protein. Efdamrofusp alfa is capable of neutralizing both VEGF isoforms and C3b/C4b. Efdamrofusp alfa can be used for the research of neovascular age-related macular degeneration (nAMD) and other complement-related ocular conditions .

HY-P99767

Olendalizumab ALXN1007	Complement System	Infection
Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (K_i=60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be used for research of complement mediated disorder caused by corona virus .

HY-P991067

Vensobafusp alfa KP-104	Complement System	Inflammation/Immunology
Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0183

Phosphatidylserine Phospholipids, phosphatidylserines; Serine glycerophosphatides	Animals Source classification	Akt TGF-β Receptor
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses .

Species:	Human (47) Rhesus Macaque (1) Mouse (20) Bovine (2) Rat (3) Cynomolgus (4) Pig (1)
Tag:	His (61) SUMO (1) Tag Free (6) Myc (1) Fc (11)
Source:	HEK293 (58) P. pastoris (3) Sf9 insect cells (1) E. coli (16)

Cat. No.	Compare	Product Name	Species	Source

HY-P7695

	Complement C5/C5a Protein, Mouse 5 Publications Verification rMuC5a; complement C5; Hemolytic complement; C5a	Mouse	E. coli
	Complement C5/C5a Protein, Mouse is a recombinant mouse complement component 5a (C5a). C5a is a potent pro-inflammatory mediator and acts as an essential part of the innate immune response.

HY-P7695A

	Complement C5/C5a Protein, Mouse (His) rMuC5a; complement C5; Hemolytic complement; C5a	Mouse	E. coli
	Complement C5/C5a Protein, Mouse is a recombinant mouse complement component 5a (C5a). C5a is a potent pro-inflammatory mediator and acts as an essential part of the innate immune response.

HY-P74232

	Complement factor H/CFH Protein, Mouse (HEK293, Fc) complement factor H; protein beta-1-H; CFH	Mouse	HEK293
	Complement factor H (CFH) protein has C3b and heparin-binding activity and plays a multifaceted role in various processes such as organ development, complement activation, and vasculature development. It is present in different cellular compartments and expressed in different structures, including the adrenal gland, bone, central nervous system, humeral cartilage condensation, and metanephros. Complement factor H/CFH Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Complement factor H/CFH protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78595

	Complement C5/C5a Protein, Cynomolgus C5a; complement Component 5a	Cynomolgus	E. coli
	Complement C5 is activated by C5 convertase, inducing C5-C9 assembly to form the membrane attack complex. The transient C6 binding site on C5b is critical for the formation of the cleavage complex. Complement C5/C5a Protein, Cynomolgus is the recombinant cynomolgus-derived Complement C5/C5a protein, expressed by E. coli , with tag free.

HY-P71552

	Complement C3/C3a Protein, Bovine (His-SUMO) C3complement C3; complement C3b alpha' chain; complement C3c alpha' chain fragment 1; complement C3dg fragment; complement C3g fragment; complement C3d fragment; complement C3f fragment; complement C3c alpha' chain fragment 2]	Bovine	E. coli
	Complement C3/C3a proteins play a key role in initiating the complement system, serving as substrates for C3 convertase in both the classical and alternative pathways. Upon activation, C3 undergoes proteolytic cleavage, yielding C3b, which is covalently bound to surface or immune aggregates. Complement C3/C3a Protein, Bovine (His-SUMO) is the recombinant bovine-derived Complement C3/C3a protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P75332

	Complement C3 Protein, Cynomolgus (HEK293, His) Anaphylatoxin; C3; complement Component C3a	Cynomolgus	HEK293
	Complement C3 proteins play a key role in initiating the complement system through processing by C3 convertase in the classical and alternative pathways. Upon activation, C3b covalently binds to the surface, while C3a (anaphylatoxin produced by proteolysis of C3) mediates local inflammation. Complement C3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Complement C3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77540

	Complement C5/C5a Protein, Mouse (Biotinylated) complement C5; Hemolytic complement; C5a	Mouse	E. coli
	Complement C5/C5a Protein activates late complement components to form the membrane attack complex, C5-C9. C5b binds C6, initiating lytic complex assembly. C5a, produced by C5 degradation, acts as an anaphylatoxin, inducing local inflammation. C5a stimulates intracellular calcium release, smooth muscle contraction, vascular permeability, histamine release, and acts as a chemokine, guiding leukocyte migration. Complement C5/C5a Protein, Mouse (Biotinylated) is the recombinant mouse-derived Complement C5/C5a protein, expressed by E. coli , with tag free.

HY-P704214

	Complement Factor D/CFP Protein, Human (HEK293, His) Properdin ; complement factor P ; CFP ; PFC	Human	HEK293

HY-P704326

	Complement C5/C5a Protein, Mouse (HEK293, His) rMuC5a; complement C5; Hemolytic complement; C5a	Mouse	HEK293

HY-P71719

	Complement C5a anaphylatoxin Protein, Pig (P.pastoris, His) C5; complement C5a anaphylatoxin	Pig	P. pastoris
	Complement C5/C5a Protein, a component of the complement system, is involved in the immune response and inflammation. It is cleaved to generate C5a, a potent pro-inflammatory mediator. Complement C5/C5a Protein's role in immune regulation and its potential as a therapeutic target make it a promising candidate for the treatment of inflammatory disorders and autoimmune diseases. Complement C5a anaphylatoxin Protein, Pig (P.pastoris, His) is the recombinant pig-derived Complement C5a anaphylatoxin protein, expressed by P. pastoris , with N-His labeled tag.

HY-P74371

	*C7/Complement* component C7 Protein, Human (HEK293, His)** complement component C7; C7	Human	HEK293
	C7, also known as complement component C7 protein, is a key component of the membrane attack complex (MAC) and plays a key role in innate and adaptive immune responses. As a component of MAC, C7 actively participates in the formation of target cell plasma membrane pores. C7/Complement component C7 Protein, Human (HEK293, His) is the recombinant human-derived C7/Complement component C7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74372

	*C7/Complement* component C7 Protein, Human (HEK293, Fc)** complement component C7; C7	Human	HEK293
	C7, also known as complement component C7 protein, is a key component of the membrane attack complex (MAC) and plays a key role in innate and adaptive immune responses. As a component of MAC, C7 actively participates in the formation of target cell plasma membrane pores. C7/Complement component C7 Protein, Human (HEK293, Fc) is the recombinant human-derived C7/Complement component C7 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74373

	*C6/Complement* component C6 Protein, Human (HEK293, His)** complement component C6; C6	Human	HEK293
	C6/Complement component C6 Protein is a part of the lytic membrane attack complex formed during complement activation, which has an indispensable role in innate and acquired immune responses by forming pores in the plasma membrane of target cells, as well as cancer immune surveillance. It is a component of the complement cascade which can be incorporated into the cell membrane and cause cell lysis. People with C6 deficiency are prone to bacterial infection. C6/Complement component C6 Protein, Human (HEK293, His) is the recombinant human-derived C6/Complement component C6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7830

	Complement factor H/CFH Protein, Mouse (HEK293, His) rMucomplement factor H/CFH, His; complement factor H; protein beta-1-H; CFH	Mouse	HEK293
	Complement factor H (CFH) lacks essential conserved residue(s) for feature annotation propagation. Complement factor H/CFH Protein, Mouse (HEK293, His) is the recombinant mouse-derived Complement factor H/CFH protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P703770

	Complement factor I Protein, Mouse (HEK293, His) complement factor I; C3B/C4B inactivator; Cfi	Mouse	HEK293

HY-P703793

	Complement factor I Protein, Human (HEK293, His) complement factor I; C3B/C4B inactivator; CFI	Human	HEK293

HY-P74374

	*C2/Complement* C2 Protein, Mouse (HEK293, His)** complement C2; C3/C5 convertase; C2	Mouse	HEK293
	Complement C2 is a component of the classical pathway of the complement system and is cleaved by activated factor C1, resulting in the formation of two distinct fragments: C2b and C2a. The subsequent serine protease activity of C2a is critical for its subsequent interaction with the complement factor C4b, leading to the formation of C3 or C5 convertase. C2/Complement C2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived C2/Complement C2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74375

	*C2/Complement* C2 Protein, Human (HEK293, His)** complement C2; C3/C5 convertase; C2	Human	HEK293
	C2/Complement C2 protein is essential in the classical pathway of the complement system. Activated by factor C1, C2 is cleaved into C2b and C2a. As a serine protease, C2a interacts with C4b, generating the C3 or C5 convertase. This crucial process activates and amplifies the complement cascade. C2/Complement C2 Protein, Human (HEK293, His) is the recombinant human-derived C2/Complement C2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74376

	*C2/Complement* C2 Protein, Human (HEK293, Fc)** complement C2; C3/C5 convertase; C2	Human	HEK293
	C2/Complement C2 protein is essential in the classical pathway of the complement system. Activated by factor C1, C2 is cleaved into C2b and C2a. As a serine protease, C2a interacts with C4b, generating the C3 or C5 convertase. This crucial process activates and amplifies the complement cascade. C2/Complement C2 Protein, Human (HEK293, Fc) is the recombinant human-derived C2/Complement C2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P700959

	Complement C5/C5a Protein, Human (His) C5a; complement C5; C5; CPAMD4; ECLZB	Human	E. coli
	Complement C5 is activated by C5 convertase, inducing C5-C9 assembly to form the membrane attack complex. The transient C6 binding site on C5b is critical for the formation of the cleavage complex. Complement C5/C5a Protein, Human (His) is the recombinant human-derived Complement C5/C5a protein, expressed by E. coli , with N-His labeled tag.

HY-P7890

	Complement factor H/CFH Protein, Human (431a.a, HEK293, His) rHucomplement factor H/CFH, His; complement factor H; CFH	Human	HEK293
	Complement factor H/CFH Protein, Human (431a.a, HEK 293, His) is a recombinant complement factor H (CFH) protein with His tag. Human complement factor H, a central complement control protein, is a member of the regulators of complement activation family.

HY-P700696

	*C1s/Complement* component C1s Protein, Human (HEK293, His)** complement C1s subcomponent; C1 esterase;	Human	HEK293
	C1s/Complement component C1s, a serine protease and B chain, forms C1 with C1q and C1r, initiating the classical complement pathway. Activated by C1r, C1s then activates downstream components C2 and C4, crucially driving the complement system cascade. C1s/Complement component C1s Protein, Human (HEK293, His) is the recombinant human-derived C1s/Complement component C1s protein, expressed by HEK293 , with C-His labeled tag.

HY-P7890A

	Complement factor H/CFH Protein, Human (431a.a, HEK293, C-His) rHucomplement factor H/CFH, His; complement factor H; CFH	Human	HEK293
	Complement factor H/CFH Protein, Human (431a.a, HEK 293, C-His) is a recombinant complement factor H (CFH) protein with His tag. Human complement factor H, a central complement control protein, is a member of the regulators of complement activation family.

HY-P70504

	Adiponectin/Acrp30 Protein, Human (HEK293, His) 1 Publications Verification Adiponectin; 30 kDa Adipocyte complement-Related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte; C1q and Collagen Domain-Containing protein; Adipose Most Abundant Gene Transcript 1 protein; apM-1; Gelatin-Binding protein; ADIPOQ; ACDC; ACRP3	Human	HEK293
	Adiponectin/Acrp30 Protein, Human (HEK293, His) could increase cell sensitivity to insulin and can be used as a potential protein for treating diabetic tendinopathy.

HY-P7862

	Complement C3/C3a Protein, Human 4 Publications Verification rHucomplement C3/C3a; complement Component C3a; C3a; Anaphylatoxin	Human	E. coli
	Complement C3/C3a protein plays a key role in initiating the complement system through processing by C3 convertase in both the classical and alternative pathways. Complement C3/C3a protein is involved in various immune and inflammatory responses and also has a role in regulating blood pressure. Complement C3/C3a Protein, Human is a recombinant Complement C3/C3a protein expressed in E. coli, untagged, and consists of 77 amino acids (S672-R748).

HY-P7863

	Complement C3/C3a Protein, Mouse 5 Publications Verification rMucomplement C3/C3a; complement Component C3a; Anaphylatoxin; C3a	Mouse	E. coli
	Complement C3/C3a protein activates the complement system, playing a central role in both classical and alternative pathways. C3b binds covalently to cell surface carbohydrates or immune aggregates, while C3a acts as an inflammatory mediator, inducing neutrophil chemoattraction and promoting smooth muscle contraction, increased vascular permeability, and histamine release. The shorter isoform of C3a stimulates B-cells. Complement C3/C3a Protein, Mouse is the recombinant mouse-derived Complement C3/C3a protein, expressed by E. coli , with tag free.

HY-P72137

	Complement Factor B/CFB Protein, Mouse (His) 1 Publications Verification Cfb; Bf; H2-Bfcomplement factor B; EC 3.4.21.47; C3/C5 convertase; complement factor B Ba fragment; complement factor B Bb fragment	Mouse	E. coli
	CFB is an important component of the alternative pathway of the complement system and is cleaved by factor D, producing two fragments: Ba and Bb. The Bb fragment is characterized as a serine protease and subsequently forms a complex with complement factor 3b, ultimately producing a C3 or C5 convertase. Complement Factor B/CFB Protein, Mouse (His) is the recombinant mouse-derived CFB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7864

	Complement C5/C5a Protein, Human rHucomplement C5/C5a; complement C5; C5a anaphylatoxin; C5a	Human	E. coli
	Complement C5/C5a Protein, Human is a recombinant human complement C5a. C5a is a 74-amino acid glycoprotein generated on activation of the C system. Complement C5 is cleaved by proteolysis in the terminal phase of complement activation generating the pro-inflammatory C5a and membrane attack complex nucleator C5b. C5a is an inflammatory mediator generated by complement activation that positively regulates various arms of immune defense, including Toll-like receptor 4 (TLR4) signaling. Complement C5/C5a Protein, Human is a human-derived recombinant protein that expressed by E. coli.

HY-P700697

	*C2/Complement* C2 Protein, Cynomolgus (HEK293, His)** complement C2; C3/C5 convertase; C2; ARMD14; CO2	Cynomolgus	HEK293
	Complement C2 is a component of the classical pathway of the complement system and is cleaved by activated factor C1, resulting in the formation of two distinct fragments: C2b and C2a. The subsequent serine protease activity of C2a is critical for its subsequent interaction with the complement factor C4b, leading to the formation of C3 or C5 convertase. C2/Complement C2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C2/Complement C2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700862

	Complement C5 Protein, Human (HEK293, His) 1 Publications Verification complement C5; C5; CPAMD4; ECLZB; C5a; C5b; C5D	Human	HEK293
	Complement C5 is activated by C5 convertase, inducing C5-C9 assembly to form the membrane attack complex. The transient C6 binding site on C5b is critical for the formation of the cleavage complex. Complement C5 Protein, Human (HEK293, His) is the recombinant human-derived Complement C5 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704336

	Complement C5 Protein, Human (HEK293, Fc) complement C5; C5; CPAMD4; ECLZB; C5a; C5b; C5D	Human	HEK293

HY-P7824

	Complement C8G Protein, Human (His) rHucomplement component C8 gamma chain/C8G, His; complement component C8 gamma chain; C8G	Human	E. coli
	C8G/C8 γ is the γ subunit of the C8 protein of the complement system and is mainly localized in brain astrocytes. C8G/C8 γ is a neuroinflammation inhibitor that interacts with S1PR2 and jointly antagonizes the pro-inflammatory activity of S1P in microglia. Complement C8G Protein, Human (His) is the recombinant human-derived Complement C8G protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72946

	Complement factor H/CFH Protein, Human (372a.a, HEK293, His) complement factor H; H factor 1; CFH; HF; HF1; HF2	Human	HEK293
	Complement factor H/CFH proteins regulate complement activation and act as soluble inhibitors to prevent complement amplification on the cell surface. Complement factor H/CFH Protein, Human (372a.a, HEK293, His) is the recombinant human-derived Complement factor H/CFH protein, expressed by HEK293 , with C-His labeled tag.

HY-P7876

	Complement Factor D/Adipsin Protein, Mouse (HEK293, His) rMucomplement Factor D/Adipsin, His; complement factor D; 28 kDa adipocyte protein; Adipsin; C3 convertase activator; Properdin factor D; Cfd; Adn; Df	Mouse	HEK293
	Complement Factor D/Adipsin Protein cleaves factor B in complex with factor C3b, activating the C3bbb complex to form the C3 convertase in the alternate pathway, analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72690

	CFHR4 Protein, Human (HEK293, His) complement factor H-related protein 4; FHR-4; CFHR4; CFHL4	Human	HEK293
	CFHR4, a key regulator of complement, intricately orchestrates the complement system. It associates with lipoproteins, suggesting involvement in lipid metabolism. Operating as a homodimer, CFHR4 plays a crucial role in balancing complement activation and regulation. CFHR4 Protein, Human (HEK293, His) is the recombinant human-derived CFHR4 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7861

	Complement Factor D/Adipsin Protein, Human (HEK293, His) rHucomplement Factor D/Adipsin, His; complement factor D; CFD; Adipsin; C3 convertase activator; Properdin factor D; DF; PFD	Human	HEK293
	Complement factor D, also known as Adipsin, plays a crucial role in the alternative pathway of the complement system and when complexed with factor C3b, it cleaves factor B. This cleavage activates the C3bbb complex, converting it to the C3 convertase of the alternative pathway. Complement Factor D/Adipsin Protein, Human (HEK293, His) is the recombinant human-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P7824A

	Complement C8G Protein, Human (N-6His) rHucomplement component C8 gamma chain/C8G, His; complement* component C8 gamma chain; C8G	Human	E. coli

HY-P704546

	Complement C5 Protein, Human (R885H, HEK293, His) complement C5; C5; CPAMD4; ECLZB; C5a; C5b; C5D	Human	HEK293

HY-P704547

	Complement C5 Protein, Human (W917S, HEK293, His) complement C5; C5; CPAMD4; ECLZB; C5a; C5b; C5D	Human	HEK293

HY-P7861A

	Complement Factor D/Adipsin Protein, Human (HEK293, His, Solution) rHucomplement Factor D/Adipsin, His; complement factor D; CFD; Adipsin; C3 convertase activator; Properdin factor D; DF; PFD	Human	HEK293
	Complement factor D, also known as Adipsin, plays a crucial role in the alternative pathway of the complement system and when complexed with factor C3b, it cleaves factor B. This cleavage activates the C3bbb complex, converting it to the C3 convertase of the alternative pathway. Complement Factor D/Adipsin Protein, Human (HEK293, His, Solution) is the recombinant human-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P72721

	CD55/DAF Protein, Human (HEK293, His) complement Decay-Accelerating factor; CD55; CR; DAF	Human	HEK293
	The CD55/DAF protein is critical in the immune system, recognizing C4b and C3b fragments, interfering with their enzymatic conversion and preventing the formation of complement cascade amplifying convertase. This regulatory mechanism alleviates complement-induced damage by inhibiting complement activation. CD55/DAF Protein, Human (HEK293, His) is the recombinant human-derived CD55/DAF protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P75394

	CD55/DAF Protein, Human (HEK293, hFc) complement Decay-Accelerating factor; CD55; CR; DAF	Human	HEK293
	The CD55/DAF protein is critical in the immune system, recognizing C4b and C3b fragments, interfering with their enzymatic conversion and preventing the formation of complement cascade amplifying convertase. This regulatory mechanism alleviates complement-induced damage by inhibiting complement activation. CD55/DAF Protein, Human (HEK293, hFc) is the recombinant human-derived CD55/DAF protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75655

	CD55/DAF Protein, Mouse (HEK293, His) complement Decay-Accelerating factor; CD55; CR; DAF	Mouse	HEK293
	The CD55/DAF protein is critical in the immune system and recognizes C4b and C3b fragments. It interacts with cell-associated C4b and C3b, interfering with their enzymatic conversion and preventing the formation of complement cascade amplifying convertase. CD55/DAF Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD55/DAF protein, expressed by HEK293 , with C-His labeled tag.

HY-P76241

	CD55/DAF Protein, Rat (HEK293, Fc) complement Decay-Accelerating factor; CD55; CR; DAF	Rat	HEK293
	The CD55/DAF protein lacks conserved residues critical for feature annotation propagation and exhibits unique qualities that have prompted exploration of its structural and functional implications. This unique property suggests underlying nuances in molecular interactions and regulatory mechanisms. CD55/DAF Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD55/DAF protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76185

	HABP1/C1QBP Protein, Mouse (His) 1 Publications Verification complement component 1 Q subcomponent-binding protein, mitochondrial; HABP1	Mouse	E. coli
	The HABP1/C1QBP proteins are part of the MAM33 family, related to a unique family of proteins known for unique characteristics and functions. Among the MAM33 family, HABP1 may play an important role in related cellular processes, but its specific function still needs to be explored. HABP1/C1QBP Protein, Mouse (His) is the recombinant mouse-derived HABP1/C1QBP protein, expressed by E. coli , with N-His labeled tag.

HY-P72691

	CFHR3 Protein, Human (HEK293, His) complement factor H-related protein 3; FHR-3; DOWN16; CFHR3; CFHL3	Human	HEK293
	CFHR3 Protein is implicated in regulating the complement system. CFHR3 Protein, Human (HEK293, His) is the recombinant human-derived CFHR3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71726

	Complement Factor D/Adipsin Protein, Rat (P.pastoris, His) Cfd; Adn; Df; complement factor D; EC 3.4.21.46; Adipsin; C3 convertase activator; Endogenous vascular elastase; Properdin factor D	Rat	P. pastoris
	Complement Factor D/Adipsin Protein is pivotal, cleaving factor B within the factor C3b complex to activate the C3bbb complex, serving as the C3 convertase in the alternate pathway—analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Rat (P.pastoris, His) is the recombinant rat-derived Complement Factor D/Adipsin protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P78247

	Complement C3 Protein, Mouse (HEK293, His) complement C3; HSE-MSF; C3; CPAMD1; AHUS5; ARMD9; ASP; C3a; C3b; HEL-S-62p	Mouse	HEK293
	Complement C3 protein activates the complement system, playing a central role in both classical and alternative pathways. C3b binds covalently to cell surface carbohydrates or immune aggregates, while C3a acts as an inflammatory mediator, inducing neutrophil chemoattraction and promoting smooth muscle contraction, increased vascular permeability, and histamine release. The shorter isoform of C3a stimulates B-cells. Complement C3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Complement C3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P702819

	Complement C3 Protein, Human (HEK293, His) complement C3; HSE-MSF; C3; CPAMD1; AHUS5; ARMD9; ASP; C3a; C3b; HEL-S-62p	Human	HEK293
	Complement C3 protein activates the complement system, playing a central role in both classical and alternative pathways. C3b binds covalently to cell surface carbohydrates or immune aggregates, while C3a acts as an inflammatory mediator, inducing neutrophil chemoattraction and promoting smooth muscle contraction, increased vascular permeability, and histamine release. The shorter isoform of C3a stimulates B-cells. Complement C3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Complement C3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704545

	Complement C3 Protein, Human (HEK293, hFc) complement C3; HSE-MSF; C3; CPAMD1; AHUS5; ARMD9; ASP; C3a; C3b; HEL-S-62p	Human	HEK293

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HY-P82566

	GC1q R Antibody (YA2311) C1QBP; GC1QBP; HABP1; SF2P32; complement component 1 Q subcomponent-binding protein; mitochondrial; GC1q-R protein; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33	WB, IP	Human, Mouse, Rat
	GC1q R Antibody (YA2311) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2311), targeting GC1q R, with a predicted molecular weight of 31 kDa (observed band size: 31 kDa). GC1q R Antibody (YA2311) can be used for WB, IP experiment in human, mouse, rat background.

HY-P80004

	Adiponectin Antibody (YA639) 30 kDa adipocyte complement related protein; ACDC; ACRP 30; ACRP30; ADIPO_HUMAN; Adipocyte; AdipoQ; Adipose most abundant gene transcript 1; Adipose specific collagen like factor; ADIPQTL1; ADPN; APM 1; apM-1; ApM1; C1q and collagen domain-containing protein; GBP 28; GBP28; Gelatin binding protein; Gelatin binding protein 28; Gelatin-binding protein.	WB, ICC/IF, IHC-P	Mouse
	Adiponectin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 27 kDa, targeting to Adiponectin. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Mouse.

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HY-145720A

Cemdisiran sodium ALN-CC5 sodium		siRNAs siRNA drugs
Cemdisiran sodium is an N-acetylgalactosamine (GalNAc) conjugated siRNA for the research of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein.

HY-145720

Cemdisiran ALN-CC5		siRNAs siRNA drugs
Cemdisiran is an N-acetylgalactosamine (GalNAc) conjugated siRNA for the research of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein.

HY-153229

Firefly luciferase mRNA-LNP		mRNA
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

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