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TNF-α/IL-1β-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TNF Receptor (70) Adrenergic Receptor (1) Akt (1) Apoptosis (6) Bacterial (3) Caspase (1) Cholinesterase (ChE) (1) Complement System (1) Dengue Virus (1) Drug Derivative (1) ERK (1) GPR65 (1) IFNAR (1) IKK (1) Integrin (1) Interleukin Related (8) IRAK (1) Isotope-Labeled Compounds (1) JNK (1) Microtubule/Tubulin (1) MMP (5) mRNA (4) NF-κB (7) Nucleoside Antimetabolite/Analog (1) p38 MAPK (1) PGE synthase (1) Phosphodiesterase (PDE) (1) PKC (1) Platelet-activating Factor Receptor (PAFR) (1) RIP kinase (2) Salt-inducible Kinase (SIK) (1) SARS-CoV (2) Small Interfering RNA (siRNA) (3) Tau Protein (1) Toll-like Receptor (TLR) (3)
By Research Areas:	Cancer (36) Cardiovascular Disease (3) Infection (7) Inflammation/Immunology (61) Metabolic Disease (3) Neurological Disease (4)
Click Chemistry:	Azide (2)
Oligonucleotides:	Nucleoside Analogs (1) Rat Pre-designed siRNA Sets (1) CpG ODNs (1) Uridine (1) Mouse Pre-designed siRNA Sets (1) mRNA (4) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Isotope-Labeled Compounds

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Click Chemistry

Oligonucleotides

Targets Recommended: TNF Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-161016

TNF/IFN-γ-IN-1	TNF Receptor IFNAR	Neurological Disease
TNF/IFN-γ-IN-1 (compound TGA) is a dual inhibitor of *TNF* and IFN-γ. TNF/IFN-γ-IN-1 can used in study Alzheimer’s disease .

HY-164102

TNF-α-IN-18	TNF Receptor NF-κB	Inflammation/Immunology
TNF-α-IN-18 (Compound 61) is an inhibitor for *TNF-α* (IC₅₀ of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC₅₀ >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis .

HY-160436

TNF-α-IN-15	TNF Receptor	Inflammation/Immunology
TNF-α-IN-15 is a *TNF-α* inhibitor. TNF-α-IN-15 can decrease the *TNF-α* blood levels .

HY-149331

TNF-α-IN-11	TNF Receptor Caspase NF-κB	Inflammation/Immunology
TNF-α-IN-11 (Compound 10) is a *TNF-α* inhibitor with a K_D value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and NF-κB signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases .

HY-160433

TNF-α-IN-12	TNF Receptor	Inflammation/Immunology
TNF-α-IN-12 is a *TNF-α* inhibitor with IC₅₀ of 0.1 μM. TNF-α-IN-12 can decrease the *TNF-α* blood levels .

HY-114573

TNF-α-IN-19	IKK Interleukin Related TNF Receptor RIP kinase	Others
TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC₅₀ values for TNFα, IL-1β, and *IL-1β/TNFα* are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β .

HY-175430

TNF-α-IN-26	TNF Receptor	Inflammation/Immunology
TNF-α-IN-26 (Compound 18) is a *TNF-α* inhibitor with an IC₅₀ of 0.10  μM for CSBP ligands. TNF-α-IN-26 inhibits LPS (HY-D1056)-stimulated TNF production in mice model. TNF-α-IN-26 can be used for inflammatory diseases research .

HY-153329

TNF-α-IN-9	TNF Receptor	Others
TNF-α-IN-9 (compound 48) is a analog of NDM-1 inhibitor-3 (HY-150758). TNF-α-IN-9 is a *TNF-α* inhibitor. TNF-α-IN-9 shows low inhibitory activity .

HY-153330

TNF-α-IN-10	Interleukin Related TNF Receptor	Inflammation/Immunology
TNF-α-IN-10 (compound 8a) is a IL-6 and *TNF-α* inhibitor. TNF-α-IN-10 shows anti-inflammatory activity .

HY-173210

TNF-α-IN-22	Apoptosis TNF Receptor	Cancer
TNF-α-IN-22 (Compound 30) is a TNFα inhibitor. It can induce Apoptosis by inhibiting the downregulation of IkBα induced by TNFα and blocking the cell cycle. TNF-α-IN-22 can be used in the research of triple-negative breast cancer .

HY-134471

TNF-α-IN-2 1 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
TNF-α-IN-2 is a potent and orally active inhibitor of *tumor necrosis factor alpha (TNFα), with an IC₅₀* of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis .

HY-142618

TNF-α-IN-6	TNF Receptor	Inflammation/Immunology
TNF-α-IN-6 (compound 12) is an orally effective allosteric inhibitor of TNFα (K_D = 6.8 nM). TNF-α-IN-6 has anti-inflammatory effects .

HY-160437

TNF-α-IN-16	TNF Receptor	Inflammation/Immunology
TNF-α-IN-16 is a potent TNFα inhibitor with an IC₅₀ of <0.6 μM. TNF-α-IN-16 has antiinflammatory properties (WO2001072735A2; example 18) .

HY-112275

TNF-α-IN-1 2 Publications Verification	TNF Receptor	Infection Cardiovascular Disease Inflammation/Immunology Cancer
TNF-α-IN-1 (Compound I-7) is a *TNF-α* inhibitor. TNF-α-IN-1 can be studied in research for cancers, heart disease, autoimmune disease and infections .

HY-160434

TNF-α-IN-13	TNF Receptor	Inflammation/Immunology
TNF-α-IN-13 is a potent TNFα inhibitor with an IC₅₀ of <0.6 μM. TNF-α-IN-13 has antiinflammatory properties (WO2001072735A2; example 6) .

HY-P1875

TNF-α (46-65), human	TNF Receptor	Inflammation/Immunology
TNF-α (46-65), human is a peptide of TNF-α.

HY-175250

TNF-α-IN-25	TNF Receptor	Inflammation/Immunology
TNF-α-IN-25 is an orally active *TNF-α* inhibitor. TNF-α-IN-25 shows Fluorescence Polarization (FP) assay IC₅₀ of 103 nM in FP binding assays and L929 assay IC₅₀ of 505 nM in cell-based assays. TNF-α-IN-25 inhibits paw swelling in the glucose-6-phosphate isomerase (GPI) arthritis model. TNF-α-IN-25 can be used for the study of arthritis .

HY-160435

TNF-α-IN-14	TNF Receptor	Inflammation/Immunology
TNF-α-IN-14 is a potent and selective TNFα inhibitor with an IC₅₀ value of 1.1 µM. TNF-α-IN-14 shows antiinflammatory properties (WO2001072735A2; compound 12) .

HY-160027

TNF-alpha-IN-1	TNF Receptor	Inflammation/Immunology
TNF-alpha-IN-1 (compound 202) is an orally active inhibitor of *TNF-alpha. TNF*-alpha-IN-1 has anti-inflammatory activity which can used in study rheumatoid arthritis, psoriasis, and asthma .

HY-172608

TNF-α-IN-24	TNF Receptor	Inflammation/Immunology
TNF-α-IN-24 (Example 15) is a *TNF-α* inhibitor with an IC₅₀ of 4.1 nM. TNF-α-IN-24 can be used in study of inflammatory and autoimmune disorders such as rheumatoid arthritis and Crohn’s disease .

HY-148908

TNF-α-IN-8	TNF Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
TNF-α-IN-8 (compound I-42) is a *TNF-α* inhibitor. TNF-α-IN-8 is an isoindole-imide compound. TNF-α-IN-8 can be used for the research of cancer, heart disease, osteoporosis, inflammatory, allergic and autoimmune diseases . TNF-α-IN-8 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-P1875A

TNF-α (46-65), human TFA	TNF Receptor	Cancer
TNF-α (46-65), human (TFA) is a peptide of human TNF-α.

HY-P1825A

TNF-α (10-36), human TFA 1 Publications Verification	TNF Receptor	Inflammation/Immunology
TNF-α (10-36), human (TFA) is a peptide of human TNF-α.

HY-P1860

TNF-α (31-45), human 5+ Cited Publications	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology Cancer
TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .

HY-110203

R-7050 Maximum Cited Publications 26 Publications Verification TNF-α Antagonist III	TNF Receptor	Cancer
R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.

HY-P1860A

TNF-α (31-45), human TFA	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology
TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .

HY-RS14786

TNF Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNF Rat Pre-designed siRNA Set A contains three designed siRNAs for TNF gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNF Rat Pre-designed siRNA Set A TNF Rat Pre-designed siRNA Set A

HY-RS14785

Tnf Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnf Mouse Pre-designed siRNA Set A Tnf Mouse Pre-designed siRNA Set A

HY-RS14784

TNF Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNF Human Pre-designed siRNA Set A contains three designed siRNAs for TNF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNF Human Pre-designed siRNA Set A TNF Human Pre-designed siRNA Set A

HY-168130

TNF-α/IL-1β-IN-1	TNF Receptor Interleukin Related	Cardiovascular Disease
TNF-α/IL-1β-IN-1 (compund 11a) is an anti-inflammatory agent that reduces the expression of *TNF-α* and IL-1β, inhibits oxidative stress and cardiomyocyte apoptosis, has good activity against septic myocardial injury, and improves myocardial blood supply in vivo .

HY-163642

TNF-α agonistic 1	Others	Cancer
TNF-α agonistic 1 (compound 22a) can repolarize tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) from the M2 phenotype to the M1 anti-tumor phenotype .

HY-100211

TAPI-2 5 Publications Verification TNF Protease Inhibitor 2	MMP SARS-CoV	Cancer
TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC₅₀ of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

HY-P99692

Lenercept p55TNF-R:Ig; Ro 45-2081; TNFR55-IgG1	TNF Receptor	Inflammation/Immunology
Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble *TNF-receptor* (p55) linked to the Fc portion of human IgG1 .

HY-P99148

*Anti-Mouse/Rat/Rabbit TNF* alpha Antibody (TN3-19.12)**	TNF Receptor	Metabolic Disease Inflammation/Immunology
Anti-Mouse TNF alpha Antibody (TN3-19.12) is an anti-mouse TNF alpha IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse TNF alpha Antibody (TN3-19.12) neutralizes cytotoxic activity in supernatants obtained from LNC-8 cells. Anti-Mouse TNF alpha Antibody (TN3-19.12) reduces the symptoms and severity of EAE (experimental allergic encephalomyelitis) in LNC-8 cells xenograft mice models. Anti-Mouse TNF alpha Antibody (TN3-19.12) prevents diabetes in NOD mice. Anti-Mouse TNF alpha Antibody (TN3-19.12) shows apparent radiosensitizing effect in CD2F1 mice .

HY-P9970A

*Infliximab (Anti-TNF-α)* Avakine (Anti-TNF-α); CT-P13 (Anti-TNF-α)	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Anti-TNF-α) (Avakine (Anti-TNF-α)) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab (Anti-TNF-α) prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab (Anti-TNF-α) has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research .

HY-174518

*Human TNF* mRNA**	mRNA	Cancer
Human TNF mRNA encodes the human tumor necrosis factor (TNF) protein, a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.

HY-156454

UCB-6876	TNF Receptor	Inflammation/Immunology
UCB-6876 is a TNFα inhibitor. UCB-6876 can specifically bind to the asymmetric crystalline form of the TNF-α trimer, with a K_D of 22 μM .

HY-147045

UCB-5307	TNF Receptor	Inflammation/Immunology
UCB-5307 is a potent *TNF* signaling inhibitor with a K_D of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex .

HY-P99772

Onfekafusp alfa L19TNF	TNF Receptor	Cancer
Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research .

HY-P99753

Nerelimomab BAYX1351	TNF Receptor	Infection
Nerelimomab (BAYX1351) is an anti-TNF-α antibody. Nerelimomab can be used for research of sepsis .

HY-P991682

Emzotamig	TNF Receptor	Inflammation/Immunology
Emzotamig is a monoclonal antibody inhibitor targeting tumor necrosis factor (TNF). Emzotamig is promising for research of autoimmune diseases associated with TNF overexpression, such as rheumatoid arthritis and ankylosing spondylitis .

HY-P990794

*Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11)*	TNF Receptor Dengue Virus	Infection Inflammation/Immunology Cancer
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) is a rat-derived IgG1 antibody inhibitor, targeting to *TNF-alpha/TNFSF2. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) neutralizes of TNF-alpha. Anti-Mouse TNF*-alpha/TNFSF2 Antibody (XT3.11) can be used for the researches of cancer, infection and immunology, such as dengue virus and B16K1 tumor .

HY-P9908

Adalimumab 10+ Cited Publications Anti-Human TNF-alpha, Human Antibody	TNF Receptor Bacterial	Inflammation/Immunology Cancer
Adalimumab is a human monoclonal IgG1 antibody targeting tumour necrosis factor α (TNF-α).

HY-150219

ODN M326 CpG-ODN M326	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN M326 (CpG-ODN M326) is a potent TLR9 agonist. ODN M326 induces the production of TNF. ODN M326 can be used as a vaccine adjuvant .

HY-118922

IW927	TNF Receptor	Inflammation/Immunology
IW927 is a photochemically enhanced *TNF-α-TNFR1* interaction inhibitor that blocks the binding of *TNF-α* to TNFRc1 with an IC₅₀ value of 50 nM. IW927 binds reversibly to the TNFRc1 with weak affinity (K_d = 40-100 μM), covalently modifies the receptor via a photochemical reaction, and does not bind the related cytokine receptors TNFRc2 or CD40. IW927 disrupts TNFα-induced IκB phosphorylation with an IC₅₀ value of 600 nM. IW927 can be used to develop light-independent inhibitors .

HY-P99565

Tengonermin ARENEGYR; NGR-TNF; NGR-hTNF	TNF Receptor	Cancer
Tengonermin (ARENEGYR) is a vascular-targeting agent consisting of the human Tumour Necrosis Factor-α (TNF-α) conjugated with the CNGRCG peptide. Tengonermin increases penetration of intratumoral chemotherapy and T-cell infiltration by modifying the tumour microenvironment .

HY-108623

Atizoram CP-80,633	Phosphodiesterase (PDE)	Inflammation/Immunology
Atizoram (CP-80,633), a cyclic nucleotide phosphodiesterase (PDE4) inhibitor, elevates plasma cyclic AMP levels and decreases tumor necrosis factor-α (TNFα) production in mice .

HY-N8277

Kdo2-Lipid A ammonium 2 Publications Verification	Toll-like Receptor (TLR) TNF Receptor	Cancer
Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both *TNF* and PGE2 .

HY-132248

C5 Lenalidomide Lenalidomide 5'-amine	TNF Receptor	Inflammation/Immunology
C5 Lenalidomide (Lenalidomide 5'-amine) (Compound 8a) is a thalidomide analog and is a potent inhibitor of *TNF-α* production (IC₅₀ = 100 μM in LPS stimulated human PBMC and IC₅₀ = 480 nM in whole blood) .

HY-19667

BMS-561392 DPC 333	TNF Receptor	Inflammation/Immunology
BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8277

Kdo2-Lipid A ammonium 2 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Toll-like Receptor (TLR) TNF Receptor
Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both *TNF* and PGE2 .

HY-N0297

Sinensetin 5+ Cited Publications Pedalitin permethyl ether	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Other Diseases Plants Disease Research Fields	PGE synthase TNF Receptor
Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties.

HY-162599

Spirohypertone B	Source classification Hypericaceae Hypericum patulum Thunb. Plants	TNF Receptor
Spirohypertone B is a potent Tumor necrosis factor-α (TNF-α) inhibitor. Spirohypertone B protects L929 cells from death induced by co-incubation with TNF-α and Actinomycin D (HY-17559) .

HY-N14533

Quinolactacin A2	Structural Classification Alkaloids Microorganisms Source classification Quinoline Alkaloids	Cholinesterase (ChE)
Quinolactacin A2 inhibits acetylcholinesterase and TNF production .

HY-108953

(S)-Quinolactacine A	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Quinoline Alkaloids Inflammation/Immunology Disease Research Fields	Others
(S)-Quinolactacine A is a quinolone inhibitor that targets *TNF* production .

HY-130073

Amorfrutin A	Structural Classification Simple Phenylpropanols Leguminosae Source classification Amorpha fruticosaL. Phenylpropanoids Plants	NF-κB Apoptosis
Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis .

HY-N6969A

Dicentrine hydrochloride	Structural Classification Alkaloids Other Alkaloids Source classification Stephania epigaea Lo Plants Menispermaceae	Adrenergic Receptor
Dicentrine hydrochloride is a drug with anti-inflammatory and anti-cancer activity. Dicentrine hydrochloride exerts its effects by enhancing TNF-α-induced apoptosis in A549 lung adenocarcinoma cells. Dicentrine hydrochloride increases caspase-8, -9, -3 and poly(ADP-ribose) polymerase (PARP) activities. Dicentrine hydrochloride inhibits TNF-α-induced invasion and migration of A549 cells. Dicentrine hydrochloride significantly inhibited the TNF-α-activated TAK1, p38, JNK and Akt signaling pathways, and reduced the transcriptional activities of NF-κB and AP-1 .

Cat. No.	Product Name	Chemical Structure

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

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