Hydrostatin-TL1  (Synonyms: H-TL1)

Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a TNF-α antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research^[1].

Hydrostatin-TL1 (1-1000 nM, 18-20 h) inhibits TNF-α-induced L929 cells death in a concentration-dependent manner ^[1].
Hydrostatin-TL1 (0.2-1.6 μM) significantly inhibits the TNF-α-induced phosphorylation of p38, ERK, JNK, and IκB protein within the NF-κB and MAPKs signaling pathways in HEK-293 cells^[1].
Hydrostatin-TL1 fails to inhibit the phosphorylation of IκB induced by IL-1β in HEK-293 cells^[1].
Hydrostatin-TL1 (0.1-0.8 nM) dose-dependently reduces TNF-α-mediated mRNA expression of pro-inflammatory factors (IL-8, TNF-α, ICAM-1, and VCAM-1) in HEK-293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydrostatin-TL1 (0.5-1 mg/kg, i.p., daily for 7-8 days) has significant anti-inflammatory activity against DSS (HY-116282C)-induced acute colitis mice model^[1].
Hydrostatin-TL1 (20-80 μg/kg, three times at 1, 3 and 5 h) dose-dependently reduces mortality in LPS (HY-D1056)-induced acute shock mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

934.11

C₃₉H₇₁N₁₁O₁₃S

2243975-43-9

Ala-Thr-Ser-Lys-Pro-Ser-Leu-Lys-Cys

ATSKPSLKC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang N, et al. Hydrostatin-TL1, an Anti-Inflammatory Active Peptide from the Venom Gland of Hydrophis cyanocinctus in the South China Sea. Int J Mol Sci. 2016 Nov 22;17(11):1940.  [Content Brief]