Search Result

Results for "

PKC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PKC (296) 5-HT Receptor (3) Adenosine Kinase (2) Akt (9) Aldose Reductase (1) AMPK (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (13) Apoptosis (66) Arrestin (1) ATM/ATR (2) Aurora Kinase (2) Autophagy (22) Bacterial (14) Bcl-2 Family (5) Beta-lactamase (2) Biochemical Assay Reagents (2) Btk (1) c-Kit (4) Calcium Channel (13) CaMK (6) Casein Kinase (1) Caspase (8) CDK (5) Checkpoint Kinase (Chk) (2) CMV (2) COX (1) Cytochrome P450 (2) DNA-PK (8) DNA/RNA Synthesis (2) Dopamine β-hydroxylase (2) Drug Metabolite (7) EGFR (5) Endogenous Metabolite (34) ERK (9) Estrogen Receptor/ERR (3) Ferroptosis (2) FLT3 (5) Fluorescent Dye (1) Fungal (4) G Protein-coupled Receptor Kinase (GRK) (2) GABA Receptor (2) GLUT (1) Glycosidase (1) GlyT (3) GPR55 (3) GSK-3 (10) HDAC (1) HIV (13) HSP (1) HSV (2) iGluR (2) IKK (1) Influenza Virus (3) Isotope-Labeled Compounds (18) JAK (3) JNK (2) Keap1-Nrf2 (4) Kisspeptin Receptor (2) Liposome (1) Lipoxygenase (2) MARCKS (3) MDM-2/p53 (1) mGluR (5) MNK (2) Monoamine Oxidase (2) mTOR (2) Myosin (5) nAChR (2) NF-κB (5) NO Synthase (9) Nucleoside Antimetabolite/Analog (2) Orexin Receptor (OX Receptor) (1) Orthopoxvirus (7) p38 MAPK (9) PAK (1) Parasite (7) PARP (2) PDGFR (1) PDK-1 (1) Phosphatase (6) Phosphodiesterase (PDE) (1) Phospholipase (1) PI3K (1) PKA (32) PKD (1) PROTACs (1) Protease Activated Receptor (PAR) (2) Proteasome (1) PTHR (1) Pyruvate Kinase (1) RABV (1) Ras (1) Reactive Oxygen Species (ROS) (9) Reference Standards (34) Reverse Transcriptase (3) ROCK (17) SARS-CoV (2) Ser/Thr Kinase (1) SHP2 (2) Small Interfering RNA (siRNA) (2) SphK (3) Src (3) STAT (4) Syk (1) Tau Protein (1) Telomerase (2) TNF Receptor (3) Topoisomerase (8) Trk Receptor (1) TRP Channel (3) TSH Receptor (1) Tyrosinase (8) VEGFR (5) VSV (2)
By Research Areas:	Cancer (183) Cardiovascular Disease (23) Endocrinology (8) Infection (36) Inflammation/Immunology (77) Metabolic Disease (41) Neurological Disease (56)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Phospholipids (1) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (1) siRNAs (2)

370

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: PKC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1286

PKC β pseudosubstrate	PKC	Neurological Disease
PKC β pseudosubstrate is a selective cell-permeable inhibitor of *PKC* .

HY-16903

PKC-IN-1	PKC	Inflammation/Immunology
PKC-IN-1 is a potent, ATP-competitive and reversible inhibitor of conventional *PKC* enzymes with K_is of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC₅₀s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.

HY-W013852

PKC-IN-6	Ser/Thr Kinase Tyrosinase PKA PKC EGFR	Cancer
PKC-IN-6 (Compound 21) is a selective inhibitor of tyrosine and serine kinases. PKC-IN-6 shows inhibitory activity against *PKC-α, PKC-δ, PKA, EGF-R* with IC₅₀ values of 240, >500, >500, >100 μM, respectively. PKC-IN-6 is promising for research of cancers .

HY-128142

PKC/PKD-IN-1	PKD PKC	Cardiovascular Disease
PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D (PKC/PKD) inhibitor with an IC₅₀ value of 0.6 nM for PKD1. PKC/PKD-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure .

HY-112681

PKC-theta inhibitor 2	PKC	Others
PKC-theta inhibitor 2 is a potent and selective *PKC-θ* inhibitor with an IC₅₀ value of 18 nM .

HY-P1286A

PKC β pseudosubstrate TFA	PKC	Neurological Disease
PKC β pseudosubstrate TFA is a selective cell-permeable inhibitor of *PKC* .

HY-169578

PKC-IN-5	PKC	Cancer
PKC-IN-5 (Compound PKCe2054) is a *PKC* inhibitor. PKC-IN-5 prevents the interaction between PKCe and its adaptor protein RACK2 .

HY-P1372

PKC ζ pseudosubstrate	PKC	Others
PKC ζ pseudosubstrate, a PKC ζ inhibitor peptide, can be attached to cell permeabilization vector peptide .

HY-147712

PKC-IN-4	PKC	Inflammation/Immunology
PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC₅₀ of 0.52 µM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature .

HY-P10085

PKC-ε translocation inhibitor peptide	PKC	Inflammation/Immunology
PKC-ε translocation inhibitor peptide is a PKC-ε translocation inhibitor. PKC-ε translocation inhibitor peptide can regulate the rate of FcγR-mediated internalization of opsonized beads, has no effect of FcαR trafficking .

HY-112681B

PKC-theta inhibitor 2 hydrochloride	PKC	Others
PKC-theta inhibitor 2 hydrochloride is a potent and selective *PKC-θ* inhibitor with an IC₅₀ value of 18 nM .

HY-126146

PKC-iota inhibitor 1 2 Publications Verification	PKC AMPK	Metabolic Disease Cancer
PKC-iota inhibitor 1 is a protein kinase C-iota (PKC-ι) inhibitor with an IC₅₀ value of 0.34 μM. PKC-iota inhibitor 1 can be used for the study of cancer .

HY-126328

PKC-theta inhibitor 1	PKC	Inflammation/Immunology
PKC-theta inhibitor 1 is the PKCθ inhibitor with an K_i value of 6 nM, inhibits IL-2 production in vivo with an IC₅₀ of 0.19 μM. PKC-theta inhibitor 1 demonstrates a reduction of symptoms in a mouse model of multiple sclerosis .

HY-P3879

Protein Kinase C (660-673) PKC βII (660-673)	PKC	Others
Protein Kinase C (660-673) (PKC βII (660-673)) is the PKC βII V5 peptide with RACK1-binding affinity .

HY-P1288

Protein Kinase C (530-558) PKC fragment (530-558)	PKC	Others
Protein Kinase C (530-558), a peptide fragment of protein kinase C (PKC), is a potent *PKC* activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption .

HY-P5886

PKC 20-28,myristoylated Myristoylated protein kinase C inhibitor 20-28	PKC	Cancer
PKC 20-28,myristoylated (Myristoylated protein kinase C inhibitor 20-28) is a cell-permeable *PKC* inhibitor that can be used in cancer research .

HY-10230

Midostaurin 30+ Cited Publications PKC412; CGP 41251	PKC VEGFR c-Kit NO Synthase Apoptosis	Cancer
Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-P1746

Protein Kinase C (19-31) 1 Publications Verification PKC (19-31)	PKC	Inflammation/Immunology
Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .

HY-10230R

Midostaurin (Standard) PKC412 (Standard); CGP 41251 (Standard)	Reference Standards PKC VEGFR c-Kit NO Synthase Apoptosis	Cancer
Midostaurin (Standard) is the analytical standard of Midostaurin. This product is intended for research and analytical applications. Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-P1746A

Protein Kinase C (19-31) (TFA) PKC (19-31) (TFA)	PKC	Inflammation/Immunology
Protein Kinase C (19-31) TFA, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .

HY-W751179

Midostaurin-13C6 PKC412-¹³C₆; CGP 41251-¹³C₆	Isotope-Labeled Compounds Apoptosis VEGFR PKC c-Kit NO Synthase	Cancer
Midostaurin- ¹³C₆ (PKC412- ¹³C₆) is the ¹³C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-10230S

Midostaurin-d5 PKC412-d₅; CGP 41251-d₅	Isotope-Labeled Compounds PKC Syk Akt PKA c-Kit	Cancer
Midostaurin-d₅ is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM .

HY-13335

PKCβ inhibitor 1	PKC Apoptosis	Cancer
PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC₅₀s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKCβ2 relative to other PKC isozymes (PKCα, PKCγ, and PKCε) .

HY-120497

PKCζ-IN-1	PKC CDK	Cancer
PKCζ-IN-1 is a compound that inhibits PKCζ and CDK2, showing an IC50 value of 5.18 nM for PKCζ and 1.04 μM for CDK2, with significant selectivity of 200-fold. PKCζ-IN-1 can reduce the activity of CDK2 while inhibiting PKCζ.

HY-P3199

PKCβII Peptide Inhibitor I	PKC	Inflammation/Immunology
PKCβII Peptide Inhibitor I is a PKCβII inhibitor. PKCβII Peptide Inhibitor I shows cardioprotective effects in rat cardiac Ischemia/reperfusion injury model. PKCβII Peptide Inhibitor I also prevents vascular endothelial dysfunction .

HY-P5888

PKCε inhibitor peptide,myristoylated Myr‐PKCɛ-	PKC	Inflammation/Immunology
PKCε inhibitor peptide,myristoylated (Myr‐PKC -) is a cell permeable myristic acid conjugated *PKC* peptide inhibitor that attenuates NO release in cultured human umbilical vein endothelial cells (HUVECs) .

HY-P3816

PKCε Inhibitor Scramble Peptide	PKC	Others
PKCε Inhibitor Scramble Peptide is a scrambled peptide with identical amino acid composition to PKCε inhibitor peptide.

HY-122858

PKCiota-IN-2	PKC	Cancer
PKCiota-IN-2 (Compound 49) is a potent PKCiota (PKC-ι) inhibitor with an IC₅₀ of 2.8 nM. PKCiota-IN-2 also inhibits *PKC-α* and *PKC-ε* with IC₅₀s of 71 nM and 350 nM, respectively .

HY-122857

PKCiota-IN-1	PKC	Cancer
PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC₅₀ of 2.7 nM. PKCiota-IN-1 also inhibits *PKC-α* and *PKC-ε* with IC₅₀s of 45 nM and 450 nM, respectively .

HY-122858A

PKCiota-IN-2 formic	PKC	Cancer
PKCiota-IN-2 formic is a potent PKCiota (PKC-ι) inhibitor with an IC₅₀ of 2.8 nM. PKCiota-IN-2 formic also inhibits *PKC-α* and *PKC-ε* with IC₅₀s of 71 nM and 350 nM, respectively .

HY-P5885

PKCη pseudosubstrate inhibitor,myristoylated	PKC	Others
PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of PKCη .

HY-P5884

PKCθ pseudosubstrate peptide inhibitor,myristoylated	PKC	Others
PKCθ pseudosubstrate peptide inhibitor, myristoylated is a synthetic peptide that can be used to study the mechanism of action of PKCθ .

HY-P5884A

PKCθ pseudosubstrate peptide inhibitor,myristoylated TFA	PKC	Others
PKCθ pseudosubstrate peptide inhibitor, myristoylated TFA is a synthetic peptide that can be used to study the mechanism of action of PKCθ .

HY-P3201

PKCζ/ι pseudosubstrate inhibitor	Pyruvate Kinase	Neurological Disease
PKCζ/ι pseudosubstrate inhibitor has broad-spectrum effects on the *PKC* enzyme family and can induce memory impairment .

HY-P10421

PKCδ substrate	ERK	Cancer
PKCδ substrate acts as a nuclear transporter of ERK2 and is involved in ERK2 mediated gene activation. PKCδ is involved in the regulation of cell growth, proliferation, cell cycle arrest, and apoptosis by phosphorylating hBVR and other proteins. PKCδ substrate can be used to study the development of diseases, especially cancer biology .

HY-P3818

PKCδ Peptide Substrate	PKC	Others
PKCδ Peptide Substrate is an absolutely specific substrate for the δ-type of PKC, with a sequence corresponding to sequence 422-443 of murine eEF-1α and containing Thr-431 .

HY-P5437

PKCε (85-92)	PKC	Others
PKCε (85-92) is a biological active peptide. (This peptide is the e-PKC specific activator, it also activates MARCKS phosphorylation in wild type cells, and has no effect on MARCKS phosphorylation in the cells derived from knockout mice.)

HY-P5881

PKCα (C2-4) inhibitor peptide	PKC	Cardiovascular Disease
PKCα (C2-4) inhibitor peptide is a PKCα specific inhibitor peptide that blocks the inhibition of I_Kr by the α_1A adrenoreceptor agonist A-61603 (HY-101366) .

HY-162234

PKCTheta-IN-1	PKC	Others
PKCTheta-IN-1 (Compound 19) is a selective macrocyclic PKCTheta inhibitor with IC₅₀ value of 0.1 nM .

HY-164756

PKCTheta-IN-2	PKC	Inflammation/Immunology
PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor with an IC₅₀ of 0.25 nM. PKCTheta-IN-2 shows good selectivity over a wide range of kinases, including the PKC subfamily (30 kinases). PKCTheta-IN-2 inhibits the IL-2 production in a mouse (IC₅₀ of 682 nM) .

HY-P5452

PKCd (8-17)	PKC	Others
PKCd (8-17) is a biological active peptide. (This peptide is derived from the V1 domain of protein kinase C (PKC)d. It inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Inhibition of PKCd reduces ischemia damage in cardiac and cerebral cells, induces proliferation of fibroblasts, and inhibits graft coronary artery disease in mice.)

HY-P1402

*[Glu27]-PKC* (19-36)**	PKC	Others
[Glu27]-PKC (19-36) is an inactive control for protein kinase C (PKC) (19-36). PKC (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C, it may be responsible for maintaining the enzyme in the inactive form in the absence of allosteric activators such as phospholipids .

HY-144307

*Aurora A/PKC-IN-1*	Aurora Kinase PKC	Cancer
Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC₅₀s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity .

HY-P3842

Protein Kinase C (661-671)	PKC	Cancer
Protein Kinase C (661-671) is a fragment peptide of β1 subspecies of protein kinase C (PKC). PKC plays a role in cellular growth control and tumor promotion .

HY-167114

*(Rac)-Aurora A/PKC-IN-1*	Aurora Kinase PKC	Cancer
(Rac)-Aurora A/PKC-IN-1 (Compund 2e) is an orally active Aurora A and PKC (α, β1, β2 and θ) kinase inhibitor. (Rac)-Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells in vitro and antimetastatic activity in vivo .

HY-P10967

EGFR Peptide	PKC	Metabolic Disease
EGFR Peptide is a selective substrate peptide for *PKC. EGFR Peptide can used to measure PKC* activity .

HY-100931

SC-10	PKC	Cancer
SC-10 is a direct activator of *PKC* .

HY-P3770

Phosphate acceptor peptide	PKC	Others
Phosphate acceptor peptide is a substrate for cAMP-dependent protein kinase (PKA). phosphate acceptor peptide is also a weak *PKC* inhibitor .

HY-P1595

CREBtide	PKA PKC	Metabolic Disease
CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA and *PKC* substrate.

HY-P1595A

CREBtide TFA	PKA PKC	Metabolic Disease
CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a PKA and *PKC* substrate .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107421

Prostratin 1 Publications Verification	Infection Structural Classification Classification of Application Fields Terpenoids Thymelaeaceae Source classification Diterpenoids Plants Disease Research Fields Wikstroemia chamaedaphne Meisn.	PKC HIV
Prostratin, a natural terpenoid compound, is a *PKC* activator, with a K_i of 12.5 nM and shows inhibitory effect on HIV-1.

HY-N11003

Vanicoside A 1 Publications Verification	Structural Classification Polygonaceae Source classification Phenols Polyphenols Plants Persicaria orientalis (L.) Spach	PKC Reactive Oxygen Species (ROS)
Vanicoside A is a phenylpropanoid glycoside. Vanicoside A can be isolated from Polygonum pensylvanicum. Vanicoside A inhibits protein kinase C (PKC), induces substantial ROS production. Vanicoside A exhibits anticancer activity against melanoma .

HY-131897

1-Stearoyl-2-arachidonoyl-sn-glycerol 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	PKC TRP Channel Endogenous Metabolite
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate *PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC)* activity .

HY-B0719

Ingenol Mebutate 4 Publications Verification Ingenol 3-angelate; PEP005	Structural Classification Classification of Application Fields Terpenoids Euphorbia peplus Linn. Diterpenoids Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	PKC
Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent *PKC* modulator, with K_is of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

HY-16982

Cercosporamide (-)-Cercosporamide	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Manihot esculenta Crantz Euphorbiaceae Plants Disease Research Fields	Fungal MNK PKC
Cercosporamide is a highly potent, ATP-competitive *PKC* kinase inhibitor targeting to *PKC1, with an IC₅₀* of <50 nM and a K_i of <7 nM. Cercosporamide is a unique Mnk inhibitor.

HY-129330

Sapintoxin D	Structural Classification Natural Products Source classification Euphorbiaceae Shirakiopsis indica (Willd.) Esser Plants	PKC
Sapintoxin D is a fluorescent phorbol ester that can be used to study the activation of protein kinase C (PKC). Sapintoxin D is a calcium-dependent PKC activator .

HY-110013

Terreic acid	Microorganisms Source classification	Btk Antibiotic
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM .

HY-N15340

1-Oleoyl-2-linoleoyl-sn-glycerol	Structural Classification Natural Products Source classification Endogenous metabolite	PKC
1-Oleoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DG). 1-Oleoyl-2-linoleoyl-sn-glycerol can activate protein kinase C (PKC), thus triggering downstream signaling cascades and promoting tumor growth. 1-Oleoyl-2-linoleoyl-sn-glycerol is promising for research of breast cancer .

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	Natural Products Animals Classification of Application Fields Source classification Disease Research Fields Cancer	PKC
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

HY-B0719R

Ingenol Mebutate (Standard) Ingenol 3-angelate (Standard); PEP005 (Standard)	Structural Classification Terpenoids Euphorbia peplus Linn. Diterpenoids Euphorbiaceae Plants	Reference Standards PKC
Ingenol Mebutate (Standard) is the analytical standard of Ingenol Mebutate. This product is intended for research and analytical applications. Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent *PKC* modulator, with K_is of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

HY-18980

Rottlerin 10+ Cited Publications Mallotoxin; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific *PKC* inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

HY-N0865

Ingenol (-)-Ingenol	Structural Classification Classification of Application Fields Terpenoids Gramineae Source classification Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Cancer	PKC
Ingenol is a *PKC* activator, with a K_i of 30 μM, with antitumor activity.

HY-N0278

Anemonin Pulsatilla camphor; Anemonine; trans-Anemonin	Structural Classification Natural Products Source classification Ranunculaceae Clematis crassifolia Benth. Plants	PKC NO Synthase
Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a *PKC-θ* inhibitor. Anemonin can significantly inhibit the translation or protein stability of *PKC-θ* protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases .

HY-113308AR

Taurolithocholic acid sodium salt (Standard)	Structural Classification Animals Source classification Steroids	Calcium Channel Endogenous Metabolite
Taurolithocholic acid (sodium salt) (Standard) is the analytical standard of Taurolithocholic acid (sodium salt). This product is intended for research and analytical applications. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist .

HY-113308A

Taurolithocholic acid sodium salt 5 Publications Verification	Structural Classification Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields Steroids	Calcium Channel Endogenous Metabolite
Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca ²⁺ agonist .

HY-108262

UCN-02 7-epi-Hydroxystaurosporine	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics Cancer	PKC PKA
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC₅₀s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells .

HY-N0278A

(Rac)-Anemonin (Rac)-Pulsatilla camphor; (Rac)-Anemonine	Structural Classification Natural Products Ranunculaceae Source classification Clematis crassifolia Benth. Plants	PKC NO Synthase
(Rac)-Anemonin ((Rac)-Pulsatilla camphor) is the diastereoisomer of Anemonin (HY-N0278). Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a *PKC-θ* inhibitor. Anemonin can significantly inhibit the translation or protein stability of *PKC-θ* protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases .

HY-N0021

Verbascoside 10+ Cited Publications Acteoside; Kusaginin; TJC160	Structural Classification Acanthaceae Neurological Disease Classification of Application Fields Anti-aging Phenols Polyphenols Acanthus mollis L. Plants Inflammation/Immunology Disease Research Fields Cancer	PKC Apoptosis Bacterial HSV
Verbascoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of *PKC, with an IC₅₀* of 25 μM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

HY-N4322

Decursinol angelate 1 Publications Verification	Structural Classification Pseudognaphalium affine (D. Don) Anderberg Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Cancer	PKC
Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities .

HY-N10393

Vibsanin A	Structural Classification Natural Products Classification of Application Fields Viburnaceae Source classification Viburnum awabuki K. Koch Plants Disease Research Fields Cancer	PKC HSP
Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a HSP90 inhibitor .

HY-137295

Ingenol 3,20-dibenzoate	Classification of Application Fields Terpenoids Source classification Diterpenoids Euphorbia esula L. Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	PKC Apoptosis
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

HY-118384

Sangivamycin 3 Publications Verification NSC 65346; BA-90912	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	PKC Nucleoside Antimetabolite/Analog
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an K_i of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers .

HY-N8018

Leucosceptoside A	Structural Classification other families Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plants	PKC Glycosidase Angiotensin-converting Enzyme (ACE)
Leucosceptoside A is a phenylethanoid glycoside with anti-hyperglycemic and anti-hypertensive activities. Leucosceptoside A shows inhibitory activity against α-glucosidase and PKCα (IC₅₀ of 19.0 μM) .

HY-121197

Balanol Ophiocordin; Azepinostatin	Structural Classification Natural Products Microorganisms Source classification	MARCKS PKA PKC
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive *PKC/PKA* inhibitor against human *PKC* isozymes α, β-I, β-II, γ, δ, ε, η (IC₅₀s=4-9 nM) and ζ (IC₅₀=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides .

HY-N2110

Phellopterin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Inflammation/Immunology Disease Research Fields	Akt
Phellopterin is a natural product isolated from Angelica dahurica. Phellopterin reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium .

HY-100618

Hispidin 1 Publications Verification	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields	PKC Endogenous Metabolite Ferroptosis Reactive Oxygen Species (ROS) p38 MAPK JAK STAT JNK Akt GSK-3 ERK Keap1-Nrf2
Hispidin, a *PKC* inhibitor and a phenolic compound can be found in Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties .

HY-N0021R

Verbascoside (Standard) Acteoside (Standard); Kusaginin (Standard); TJC160 (Standard)	Structural Classification Acanthaceae Phenols Polyphenols Acanthus mollis L. Plants	Reference Standards PKC Apoptosis Bacterial HSV
Verbascoside (Standard) is the analytical standard of Verbascoside. This product is intended for research and analytical applications. Verbascoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC₅₀ of 25 μM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

HY-118834

Teleocidin A1 Lyngbyatoxin A	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids Cancer	PKC
Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C *(PKC)*. Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC₅₀=9.2 nM) .

HY-101047

D-erythro-Sphingosine 4 Publications Verification Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Phosphatase Endogenous Metabolite
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-N8475

6-Deoxyisojacareubin	Structural Classification Flavonoids Guttiferae Source classification Plants Other Flavonoids Garcinia nervosa (Miq.) Miq.	PKC
6-Deoxyisojacareubin is a *PKC* inhibitor that inhibits the proliferation of QGY-7703 cells in a concentration-dependent manner. 6-Deoxyisojacareubin is also a natural product that can be obtained from Garcinia nervosa. 6-Deoxyisojacareubin can be used in cancer research .

HY-N4322R

Decursinol angelate (Standard)	Structural Classification Pseudognaphalium affine (D. Don) Anderberg Source classification Coumarins Phenylpropanoids Umbelliferae Plants	Reference Standards PKC
Decursinol angelate (Standard) is the analytical standard of Decursinol angelate. This product is intended for research and analytical applications. Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities .

HY-N8306

Isojacareubin	Structural Classification Flavonoids Flavones Source classification Guttiferae Plants Hypericum japonicum Thunb. ex Murray	Bacterial PKC Apoptosis SARS-CoV
Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits *PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis* .

HY-13626

Spisulosine 1 Publications Verification ES-285	Alkaloids Animals Classification of Application Fields Other Alkaloids Marine natural products Source classification Other marine organisms Disease Research Fields Cancer	PKC Apoptosis
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-N0152

Myricitrin 1 Publications Verification	Cardiovascular Disease Flavonols Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Flavonoids Phenols Polyphenols Myrica nagi Disease Research Fields Myricaceae	PKC NO Synthase TNF Receptor Parasite
Myricitrin, a naturally occurring flavonoid, is an orally active nitric oxide (NO) and *PKC* inhibitor. Myricitrin has central nervous system activity, including anxiolytic-like action. Myricitrin possesses antioxidant, anti-inflammatory, antifibrotic and anti-malarial effects .

HY-118384R

Sangivamycin (Standard) NSC 65346 (Standard); BA-90912 (Standard)	Structural Classification Natural Products Microorganisms Source classification	Reference Standards PKC Nucleoside Antimetabolite/Analog
Sangivamycin (Standard) is the analytical standard of Sangivamycin. This product is intended for research and analytical applications. Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2].

HY-N8303

Gardenin A	Structural Classification Flavonoids Flavones Source classification Rutaceae Plants Citrus reticulata Blanco	ERK PAK
Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, *PKC, and PKA*, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects .

HY-N6734

K-252b	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	PKC
K-252b, an indolocarbazole isolated from the actinomycete Nocardiopsis, is a *PKC* inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through cell membrane freely .

HY-133680

β-Tocopherol	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Palmae Plants Disease Research Fields Trachycarpus fortunei (Hook.) H. Wendl.	Tyrosinase
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-N2180

Pinoresinol dimethyl ether (+)-Eudesmin	Structural Classification Neurological Disease Classification of Application Fields Magnoliaceae Source classification Lignans Phenylpropanoids Magnolia biondii Pamp. Plants Disease Research Fields	PKC PKA p38 MAPK NO Synthase
Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furanoid lignin. Pinoresinol dimethyl ether can be isolated from Magnolia biondii. Pinoresinol dimethyl ether activates MAPK, *PKC, and PKA* upstream pathways and inhibits NO levels. Pinoresinol dimethyl ether has neuroprotective activity .

HY-N6786

Ochratoxin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Disease Research Fields Cancer	Endogenous Metabolite
Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .

HY-13434

Ionomycin 80+ Cited Publications SQ23377	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-N0453

Hypericin 5 Publications Verification	Structural Classification Natural Products Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Hyperlcurn perforatum L. Plants Disease Research Fields Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of *PKC* (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-N2110R

Phellopterin (Standard)	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Reference Standards Akt
Phellopterin (Standard) is the analytical standard of Phellopterin. This product is intended for research and analytical applications. Phellopterin is a natural product isolated from Angelica dahurica. Phellopterin reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium .

HY-N13191

Ingenol 3-monobenzoate Ingenol 3-benzoate	Structural Classification Natural Products Source classification Euphorbia esula L. Euphorbiaceae Plants	PKC
Ingenol 3-monobenzoate (Ingenol 3-benzoate) is a disgust inducing agent. Ingenol 3-monobenzoate can bind to and activate *PKC* (K_i=0.14 nM), inhibit the gene expression of phosphoenolpyruvate carboxykinase, thereby inhibiting gluconeogenesis, and increasing blood cortisol levels, producing food aversion .

HY-15141

Staurosporine 150+ Cited Publications Antibiotic AM-2282; STS; AM-2282	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Marine natural products Source classification Marine microorganism Disease Research Fields Indole Alkaloids	PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for *PKC, PKA, c-Fgr, and Phosphorylase kinase* respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-129099

N-Desmethyltamoxifen	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-N6743

Cercosporin CGP049090	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Cancer	PKC
Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations . Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC₅₀ of 0.6-1.3 μM .

HY-100618R

Hispidin (Standard)	Structural Classification Microorganisms Source classification Phenols Polyphenols Endogenous metabolite	Reference Standards PKC Endogenous Metabolite Ferroptosis Reactive Oxygen Species (ROS) p38 MAPK JAK STAT JNK Akt GSK-3 ERK Keap1-Nrf2
Hispidin (Standard) is the analytical standard of Hispidin. This product is intended for research and analytical applications. Hispidin, a PKC inhibitor and a phenolic compound can be found in Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties[1][2][3][4][5][6][7].

HY-129099A

N-Desmethyltamoxifen hydrochloride	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-113068

(rel)-β-Tocopherol	Structural Classification Monophenols Microorganisms Classification of Application Fields Agrostidoideae Source classification Phenols Metabolic Disease Plants Disease Research Fields Triticum aestivum L.	Tyrosinase
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

Cat. No.	Product Name	Chemical Structure

HY-10230S

Midostaurin-d5
Midostaurin-d₅ is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM .

HY-13502S

Mitoxantrone-d8
Mitoxantrone-d₈ (mitozantrone-d₈) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM .

HY-101047S

D-erythro-Sphingosine-d7
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-113068S

β-Tocopherol-d3
β-Tocopherol-d₃ is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-W751179

Midostaurin-13C6

Midostaurin- ¹³C₆ (PKC412- ¹³C₆) is the ¹³C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-129491S

O-Desmethyl Midostaurin-d5
O-Desmethyl Midostaurin-d₅ is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism .

HY-W751181

O-Desmethyl midostaurin-13C6

O-Desmethyl midostaurin- ¹³C₆ (CGP62221- ¹³C₆; O-Desmethyl PKC412- ¹³C₆) is the ¹³C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor?with?IC₅₀?ranging from 22-500 nM.

HY-10195BS

Ruboxistaurin-d6 hydrochloride
Ruboxistaurin-d₆ (hydrochloride) is the deuterium labeled Ruboxistaurin hydrochloride. Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC₅₀ of 4.7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC₅₀ of 5.9 nM .

HY-W751180

3-Hydroxy Midostaurin-13C6

3-Hydroxy Midostaurin- ¹³C₆ (CGP52421- ¹³C₆) is the ¹³C-labeled 3-Hydroxy Midostaurin (HY-108263). 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC₅₀s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .

HY-108263S

3-Hydroxy Midostaurin-d5
3-Hydroxy Midostaurin-d₅ is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC₅₀s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively .

HY-115767S

(±)-1,2-Diolein-13C3
(±)-1,2-Diolein- ¹³C₃ (1,2-Dioleoyl-rac-glycerol- ¹³C₃) is ¹³C labeled (±)-1,2-Diolein. (±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a *PKC* activator. (±)-1,2-Diolein increases myotubes Ca ²⁺ influx .

HY-13626S

Spisulosine-d3
Spisulosine-d₃ (ES-285-d₃) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-133680S

β-Tocopherol-d4
β-Tocopherol-d4 is a deuterium labeled β-Tocopherol (HY-133680). β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-101047S1

D-erythro-Sphingosine-13C2,d2
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-113202S

Stearoyl-L-carnitine-d3

Stearoyl-L-carnitine-d₃ is the deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2 .

HY-13502AS

Mitoxantrone-d8 dihydrochloride

Mitoxantrone-d₈ dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502AS1

Mitoxantrone-d8 hydrochloride

Mitoxantrone-d₈ (hydrochloride) (Mitozantrone-d₈ (hydrochloride)) is deuterium labeled Mitoxantrone (dihydrochloride). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-131897S

1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
1-Stearoyl-2-Arachidonoyl-d₈-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .

HY-113202S1

Stearoyl-L-carnitine-d9 chloride

Stearoyl-L-carnitine-d9 chloride is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride, a fatty ester lipid molecule, is an endogenous metabolite. Stearoyl-L-carnitine chloride can be used as PKC inhibitor. Stearoyl-L-carnitine chloride accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoyl-L-carnitine chloride inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoyl-L-carnitine chloride acts as a metabolomics biomarker for Parkinson’s disease. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2 .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks