Iso-H7 dihydrochloride

Cat. No.: HY-126376 Purity: 99.06%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Iso-H7 dihydrochloride is an inhibitor of protein kinase with IC₅₀ values of 22 and 34 μM to PKC and PKA respectively. Iso-H7 dihydrochloride has negative control of PKA on satellite cell myogenesis.

For research use only. We do not sell to patients.

Iso-H7 dihydrochloride Chemical Structure

CAS No. : 140663-38-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PKC Isoform Specific Products:

View All Isoforms

PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

View All PKA Isoform Specific Products:

View All Isoforms

PKA PKAR PKACα

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

364.29

Formula

C₁₄H₁₉Cl₂N₃O₂S

CAS No.

140663-38-3

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=CC2=C1C=CN=C2)(N3CC(C)NCC3)=O.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (137.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7451 mL	13.7253 mL	27.4507 mL
5 mM	0.5490 mL	2.7451 mL	5.4901 mL
10 mM	0.2745 mL	1.3725 mL	2.7451 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.06%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (255 KB) HNMR (277 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. C Lagord, et al. Satellite cell myogenesis is highly stimulated by the kinase inhibitor iso-H7: comparison with HA1004 and staurosporine effects. Biochem Biophys Res Commun. 1993, 191, 3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7451 mL	13.7253 mL	27.4507 mL	68.6266 mL
	5 mM	0.5490 mL	2.7451 mL	5.4901 mL	13.7253 mL
	10 mM	0.2745 mL	1.3725 mL	2.7451 mL	6.8627 mL
	15 mM	0.1830 mL	0.9150 mL	1.8300 mL	4.5751 mL
	20 mM	0.1373 mL	0.6863 mL	1.3725 mL	3.4313 mL
	25 mM	0.1098 mL	0.5490 mL	1.0980 mL	2.7451 mL
	30 mM	0.0915 mL	0.4575 mL	0.9150 mL	2.2876 mL
	40 mM	0.0686 mL	0.3431 mL	0.6863 mL	1.7157 mL
	50 mM	0.0549 mL	0.2745 mL	0.5490 mL	1.3725 mL
	60 mM	0.0458 mL	0.2288 mL	0.4575 mL	1.1438 mL
	80 mM	0.0343 mL	0.1716 mL	0.3431 mL	0.8578 mL
	100 mM	0.0275 mL	0.1373 mL	0.2745 mL	0.6863 mL