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Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activatedprotein (MAP) kinase-activatedprotein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1 .
N-Methylparoxetine is a derivative of Paroxetine that induces Apoptosis NSCLC cells by activatingmitogen-activatedprotein kinase ( MAPK). N-Methylparoxetine has antitumor activity .
N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca 2+ and reactive oxygen species (ROS), increases the activity of mitogen-activatedprotein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .
R 1487 is an orally active and highly selective p38α mitogen-activatedprotein kinase inhibitor. R 1487 can be used in the study of rheumatoid arthritis .
Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activatedprotein kinase-activatedprotein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases .
AKP-001 is an inhibitor of p38 mitogen-activatedprotein kinase (p38 MAPK). AKP-001 can inhibit the production of inflammatory cytokines and can be used for research in rheumatoid arthritis and inflammatory bowel disease .
(R)-PD 0325901CL is an isomer of PD 0325901CL. PD 0325901CL is a selective inhibitor of mitogen-activatedprotein kinase kinase (MEK) involved in cancer research. PD 0325901CL inhibits the growth of cancer cells in vitro and in vivo .
P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activatedprotein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis .
(R)-Zunsemetinib is the isomer of Zunsemetinib (HY-139553), and can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activatedprotein kinase-activatedprotein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases .
Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activatedprotein kinase kinase (MKK)3 and MKK6 inhibitor with strongly attenuates the MKK3/6-p38 signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities .
Klotho-derived peptide 1 (KP1 human) blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activatedprotein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model .
Link N peptide is a proteoglycan aggregatesactivator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activatedprotein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases .
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities .
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activatedprotein kinase (MAPK) signaling pathways .
TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activatedprotein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41.1 nM and 18.2 nM, respectively.
Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activatedprotein kinase signaling .
Raxofelast (IRFI-016) is an antioxidant agent in various models of ischemia-reperfusion injury. Raxofelast has antiproliferative activity in H2O2-stimulated rat aortic smooth muscle cells. Raxofelast attenuates the activation of mitogen-activatingprotein kinase (MAPK), ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression .
3,4-Dephostatin (Methyl-3,4-dephostatin) is an inhibitor of protein-tyrosine phosphatase (PTPase). 3,4-Dephostatin accelerates nerve growth factor (NGF)-induced neurite formation in PC12h cells. 3,4-Dephostatin sustains the NGF-induced tyrosine phosphorylation of proteins, most prominently that of mitogen-activatedprotein (MAP) kinase. 3,4-Dephostatin also prolongs epidermal growth factor (EGF)-induced tyrosine phosphorylation and activation of MAP kinase .
ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. Mitogen-activatedprotein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 5 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2020238776A1) .
ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. Mitogen-activatedprotein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 5 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2020238776A1) .
Asperulosidic Acid (Standard) is the analytical standard of Asperulosidic Acid. This product is intended for research and analytical applications. Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities .
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activatedprotein kinase (MAPK) signaling pathways .
ERK1/2 inhibitor 6 is a potent inhibitor of ERK1/2. Mitogen-activatedprotein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 6 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2021063335A1, compound 1) .
ERK1/2 inhibitor 3 is a potent inhibitor of ERK1/2. Mitogen-activatedprotein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 3 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2021218912A1, compound 1) .
Darizmetinib (HRX-0215) is an orally active, potent and selective inhibitor of mitogen-activatedprotein kinase kinase 4 (MKK4). Darizmetinib leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration. Darizmetinib is promising for research of preventing liver failure after extensive oncological liver resections or transplantation of small liver grafts .
Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC50 value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activatedprotein kinase (MAPK) and NF-κB signaling pathways .
Strontium Ranelate (Standard) is the analytical standard of Strontium Ranelate. This product is intended for research and analytical applications. Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activatedprotein kinase signaling .
3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC50 of 2.2 μM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activatedprotein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model .
IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activatedprotein kinase (IC50=4.3 μM). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis .
Scio-323 is an orally available p38 mitogen-activatedprotein kinase (MAPK) inhibitor with the potential to inhibit chronic inflammatory responses associated with polyethylene particles. Scio-323's oral inhibition pattern had a minimal effect on bone formation. Scio-323 administration inhibited net bone formation after the establishment of a chronic inflammatory response to polyethylene particles. Osteoblast-like activity remained low in all cases of Scio-323 inhibition. Scio-323 failed to improve bone growth in the presence of polyethylene particles .
MK2-IN-7 (Compound 144) is a mitogen activatedprotein kinase-activatedprotein kinase-2 (MK2) inhibitor. MK2-IN-7 is promising for research of inflammatory diseases, autoimmune diseases and cancer .
3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase (JNK) and p38mitogen-activatedprotein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research .
1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE 18:1) is a lysophosphatidylethanolamine molecule involved in phospholipid metabolism, targeting cell membrane receptors (such as G protein-coupled receptors) to regulate cell signaling pathways. 1-oleoyl-sn-glycero-3-phosphoethanolamine may activatemitogen-activatedprotein kinase (MAPK) signaling, promote cell migration, regulate inflammatory responses and lipid metabolism, and has both pro-inflammatory and anti-inflammatory activities. 1-oleoyl-sn-glycero-3-phosphoethanolamine is mainly used in the screening of biomarkers for metabolic diseases (such as non-alcoholic fatty liver disease and obesity), as well as the study of the mechanism of lysophospholipids in cell membrane homeostasis and signal transduction .
Methylcarbamyl PAF C-8 is resistant to the degradation function of platelet-activating factor acetylhydrolase (PAF-AH). It has a half-life of more than 100 minutes in platelet-poor plasma and possesses the activity of inducing platelet aggregation. In NRK-49 cells overexpressing the PAF receptor, Methylcarbamyl PAF C-8 can induce the expression of c-myc and c-fos, and activatemitogen-activatedprotein kinase (MAPK). Additionally, Methylcarbamyl PAF C-8 can induce cell cycle arrest in the G1 phase. Methylcarbamyl PAF C-8 holds promise for research in the fields of cardiovascular diseases and anti-cancer therapy .
MMI-0100 is a cell-permeant peptide inhibitor of mitogen activatedprotein kinase activatedprotein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease .
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activatedprotein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway .
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta .
Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) .
Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activatedprotein kinase (MAPK) signaling pathways .
SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation .
Esculentoside A (Standard) is the analytical standard of Esculentoside A. This product is intended for research and analytical applications. Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta .
Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) .
Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activatedprotein kinase (MAPK) signaling pathways .
ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM .
Formoterol (hemifumarate hydrate) (Standard) is the analytical standard of Formoterol (hemifumarate hydrate). This product is intended for research and analytical applications. Formoterol hemifumarate hydrate is a selective, long-acting beta 2-adrenoceptor agonist. Formoterol is a bronchodilator used for the research of the asthma and chronic obstructive pulmonary disease (COPD). Formoterol hemifumarate hydrate induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury .
PD 198306 is a selective MAPK/ERK-kinase (MEK) inhibitor. PD 198306 results in an observable reduction in the Streptozocin induced increase in the level of active ERK1 and 2. Antihyperalgesic effects .
Link N peptide is a proteoglycan aggregatesactivator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activatedprotein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases .
MMI-0100 is a cell-permeant peptide inhibitor of mitogen activatedprotein kinase activatedprotein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease .
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activatedprotein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway .
P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activatedprotein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis .
Klotho-derived peptide 1 (KP1 human) blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activatedprotein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model .
N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca 2+ and reactive oxygen species (ROS), increases the activity of mitogen-activatedprotein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .
Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activatedprotein kinase kinase (MKK)3 and MKK6 inhibitor with strongly attenuates the MKK3/6-p38 signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities .
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities .
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activatedprotein kinase (MAPK) signaling pathways .
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta .
Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) .
Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activatedprotein kinase (MAPK) signaling pathways .
Formoterol (hemifumarate hydrate) (Standard) is the analytical standard of Formoterol (hemifumarate hydrate). This product is intended for research and analytical applications. Formoterol hemifumarate hydrate is a selective, long-acting beta 2-adrenoceptor agonist. Formoterol is a bronchodilator used for the research of the asthma and chronic obstructive pulmonary disease (COPD). Formoterol hemifumarate hydrate induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury .
Asperulosidic Acid (Standard) is the analytical standard of Asperulosidic Acid. This product is intended for research and analytical applications. Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities .
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activatedprotein kinase (MAPK) signaling pathways .
Esculentoside A (Standard) is the analytical standard of Esculentoside A. This product is intended for research and analytical applications. Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta .
Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) .
Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activatedprotein kinase (MAPK) signaling pathways .
JNK1 is a multifunctional serine/threonine protein kinase that complexly regulates multiple cellular processes, including cell proliferation, apoptosis, and differentiation. JNK1 is activated by MAP2K4/MKK4 and MAP2K7/MKK7, phosphorylates AP-1 components, and affects transcriptional activity. JNK1 Protein, Human (sf9, GST) is the recombinant human-derived JNK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag.
Ragulator Complex protein LAMTOR3; Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 3; MEK-Binding Partner 1; Mp1; mitogen-activatedprotein Kinase Kinase 1-Interacting protein 1; mitogen-activatedprotein Kinase Scaffold protein 1; LAMTOR3; MAP2K1IP
The MAPKSP1 protein, also known as porphobilinogen deaminase (HMBS), is crucial in the heme biosynthetic pathway and catalyzes the sequential polymerization of four porphobilinogen molecules to form hydroxymethyl bixane. The process begins with the assembly of the dipyrromethane cofactor of porphobilinogen or preuroporphyrinogen. MAPKSP1 Protein, Human (His) is the recombinant human-derived MAPKSP1 protein, expressed by E. coli , with N-6*His labeled tag.
The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K6 Protein, Human (sf9, His) is the recombinant human-derived MAP2K6 protein, expressed by sf9 insect cells , with N-6*His labeled tag.
The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (sf9) is the recombinant human-derived P38β protein, expressed by sf9 insect cells , with tag free.
The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (sf9, GST) is the recombinant human-derived P38β protein, expressed by sf9 insect cells , with N-GST labeled tag.
The p38 delta/MAPK13 protein is an important serine/threonine kinase in the MAP kinase pathway. It coordinates cellular responses to stimuli such as cytokines or stress and directly activates the transcription factors ELK1 and ATF2. In this cascade, p38 MAPK (including MAPK13) each phosphorylates approximately 200 to 300 substrates. p38 delta/MAPK13 Protein, Human (sf9, GST) is the recombinant human-derived p38 delta/MAPK13 protein, expressed by Sf9 insect cells , with N-GST labeled tag.
MAP3K1 is a key component of the protein kinase signal transduction cascade and plays a crucial role in cell signaling pathways.Through its kinase activity, MAP3K1 coordinates the activation of the ERK and JNK kinase pathways by phosphorylating MAP2K1 and MAP2K4.MAP3K1 Protein, Mouse (His) is the recombinant mouse-derived MAP3K1 protein, expressed by E.coli , with N-6*His labeled tag.
ERK2 Protein, a key component of the MAPK/ERK cascade, regulates diverse cellular processes such as transcription, translation, mitosis, apoptosis, endosomal dynamics, and Golgi apparatus fragmentation. Through phosphorylation, it modulates substrates including transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, protein kinases, and phosphatases. MAPK1/ERK2 Protein, Human (sf9, His) is the recombinant human-derived ERK2 protein, expressed by Sf9 insect cells , with C-His labeled tag.
MAP3K8/TPL-2 is critical for LPS-induced, TLR4-mediated activation of MAPK/ERK, leading to TNF production by macrophages. It regulates T cell differentiation, IFNG expression, and host resistance to bacterial infections by negatively regulating type I interferon production. MAP3K8/TPL-2 Protein, Human (sf9, GST) is the recombinant human-derived MAP3K8/TPL-2 protein, expressed by Sf9 insect cells , with N-GST labeled tag.
The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (sf9) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells , with tag free and with residual Gly-Pro in N-terminal (not related to functional changes).
MAP3K19 is a protein kinase involved in intracellular signaling. MAP3K19 can directly activate the ERK and JNK pathways and plays an important role in maintaining the survival of KRAS-mutant lung cancer cells. In addition, MAP3K19 also regulates allergic airway inflammation in patients with asthma by inhibiting airway epithelial responses stimulated by TWEAK, including reduced adhesion factors and production of RANTES, and suppressing allergic airway inflammation in a mouse model of asthma. RCK Protein, Human (His) is the recombinant human-derived RCK protein, expressed by E. coli , with N-6*His labeled tag.
The p38 α/MAPK14 protein is an important serine/threonine kinase in the MAP kinase pathway. It can respond to stimuli such as cytokines or stress and directly activate transcription factors. In this cascade, p38 MAPK each phosphorylates approximately 200 to 300 substrates, including the downstream kinases RPS6KA5/MSK1 and RPS6KA4/MSK2, which are critical for immediate early gene induction. p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) is the recombinant human-derived p38 alpha/MAPK14 protein, expressed by Sf9 insect cells , with N-His labeled tag.
The MEK1 protein is a dual-specificity kinase that plays a crucial role in the MAP kinase pathway.MEK1 regulates various cellular processes such as growth, adhesion, survival, and differentiation, as well as transcription, metabolism, and cytoskeletal rearrangements.MEK1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived MEK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (sf9) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells , with tag free.
The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (sf9, His-GST) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
MAP4K2 is a serine/threonine protein kinase and an important component of the MAP kinase signal transduction pathway. It acts as a MAPK kinase kinase (MAP4K), activating the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) pathway and, to a lesser extent, the p38 MAPKs pathway. MAP4K2 Protein, Human (sf9, His-GST) is the recombinant human-derived MAP4K2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (sf9, His-GST) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (S207D, T211D, sf9) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells , with tag free.
ERK2 Protein, a key component of the MAPK/ERK cascade, regulates diverse cellular processes such as transcription, translation, mitosis, apoptosis, endosomal dynamics, and Golgi apparatus fragmentation. Through phosphorylation, it modulates substrates including transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, protein kinases, and phosphatases. MAPK1/ERK2 Protein, Human (Flag, His) is the recombinant human-derived MAPK1, expressed by E. coli , with His, Flag labeled tag. ,
The MAPKAPK2 protein is a stress-activated kinase involved in multiple cellular processes, including cytokine production, endocytosis, cytoskeletal reorganization, cell migration, cell cycle control, chromatin remodeling, DNA damage response, and transcriptional regulation. MAPKAPK2 Protein, Human (323a.a) is the recombinant human-derived MAPKAPK2, expressed by E. coli , with tag Free labeled tag. ,
ERK3 Protein, an atypical MAPK, phosphorylates MAP2 and MAPKAPK5. Interacting with MAPKAPK5, ERK3/MAPK6 undergoes Ser-189 phosphorylation, facilitating MAPKAPK5 activation. Activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The complex's precise functional implications, especially in cell cycle entry, remain elusive. ERK3 Protein, Human (L290V) is the recombinant human-derived ERK3 protein, expressed by E. coli , with tag free.
ERK3 Protein, an atypical MAPK, phosphorylates MAP2 and MAPKAPK5. Interacting with MAPKAPK5, ERK3/MAPK6 undergoes Ser-189 phosphorylation, facilitating MAPKAPK5 activation. Activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The complex's precise functional implications, especially in cell cycle entry, remain elusive. ERK3 Protein, Human (L290V, His) is the recombinant human-derived ERK3 protein, expressed by E. coli , with N-6*His labeled tag.
MAPK4, an atypical MAPK protein, phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5, forming a complex with intricate phosphorylation events. Interaction with MAPKAPK5 leads to ERK3/MAPK6 phosphorylation at Ser-189, activating MAPKAPK5, which reciprocally phosphorylates ERK3/MAPK6. The specific cellular role of this interplay, while unclear, suggests ERK3's potential involvement in promoting entry into the cell cycle. MAPK4 Protein, Human (sf9, His, GST) is the recombinant human-derived MAPK4 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.
ASK1 protein is a key serine/threonine kinase in the MAP kinase pathway, coordinating cellular responses to environmental changes and affecting cell fate, differentiation, and survival. ASK1 is a key player in apoptosis and promotes mitochondria-dependent caspase activation. ASK1 Protein, Human (His) is the recombinant human-derived ASK1 protein, expressed by E. coli , with C-6*His labeled tag.
TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; mitogen-activatedprotein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1
The TAB1 protein is a key adapter that activates JNK, NF-kappa-B, and proinflammatory cytokines in response to TLR and cytokine stimulation. It binds to MAP3K7/TAK1, inducing autophosphorylation and full activation. TAB1 Protein, Human (His) is the recombinant human-derived TAB1 protein, expressed by E. coli , with N-6*His labeled tag.
TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; mitogen-activatedprotein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1
The TAB1 protein is a key adapter that activates JNK, NF-kappa-B, and proinflammatory cytokines in response to TLR and cytokine stimulation. It binds to MAP3K7/TAK1, inducing autophosphorylation and full activation. TAB1 Protein, Human is the recombinant human-derived TAB1 protein, expressed by E. coli , with tag free.
JNK3 is a critical serine/threonine protein kinase in neuronal processes, regulating proliferation, differentiation, migration, and apoptosis. Activation through MAP2K4/MKK4 and MAP2K7/MKK7 leads to phosphorylation of JNK3, which in turn phosphorylates AP-1 components such as JUN and ATF2, thereby regulating AP-1 transcriptional activity. JNK3 Protein, Human (His) is the recombinant human-derived JNK3 protein, expressed by E. coli , with N-6*His labeled tag.
The MAPKAPK3 protein is a stress-activated kinase involved in multiple cellular processes, including cytokine production and endocytosis. It is phosphorylated by p38-alpha/MAPK14 during stress, targets specific substrates, and has similarities to MAPKAPK2 but is less active. MAPKAPK3 Protein, Human (Active, sf9, GST) is the recombinant human-derived MAPKAPK3, expressed by Sf9 insect cells , with GST labeled tag. ,
ERK1 protein is an important serine/threonine kinase in the MAP kinase pathway and cooperates with MAPK1/ERK2 to activate the MAPK/ERK cascade. Stimulated by KIT and KITLG/SCF, this pathway plays a key role in cell growth, adhesion, survival, and differentiation. ERK1 Protein, Human (GST) is the recombinant human-derived ERK1 protein, expressed by E. coli , with N-GST labeled tag.
JNK3 is a critical serine/threonine protein kinase in neuronal processes, regulating proliferation, differentiation, migration, and apoptosis. Activation through MAP2K4/MKK4 and MAP2K7/MKK7 leads to phosphorylation of JNK3, which in turn phosphorylates AP-1 components such as JUN and ATF2, thereby regulating AP-1 transcriptional activity. JNK3 Protein, Human is the recombinant human-derived JNK3 protein, expressed by E. coli , with tag free.
MAP4K6 protein is a key serine/threonine kinase that negatively regulates Ras-related Rap2-mediated signaling, affecting neuronal structure and AMPA receptor trafficking. Its importance is underlined by its important role in regulating synaptic density, dendritic complexity, and surface AMPA receptor expression in hippocampal neurons. MAP4K6 Protein, Human (sf9, GST) is the recombinant human-derived MAP4K6 protein, expressed by sf9 insect cells , with N-GST labeled tag.
The MAP2K4 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K4 Protein, Human (P. pastoris, His-GST) is the recombinant human-derived MAP2K4 protein, expressed by P. pastoris , with N-6*His, N-GST labeled tag.
The MAP2K4 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K4 Protein, Human (sf9) is the recombinant human-derived MAP2K4 protein, expressed by sf9 insect cells , tag free.
TAK1 Antibody (YA663) is a non-conjugated and Mouse origined monoclonal antibody about 67 kDa, targeting to TAK1 (3G1). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.
MEK3 Antibody (YA3214) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3214), targeting MEK3, with a predicted molecular weight of 39 kDa (observed band size: 38-40 kDa). MEK3 Antibody (YA3214) can be used for WB, ICC/IF,IP experiment in human, mouse, rat background.
Phospho-TAK1 (Ser439) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 67 kDa, targeting to Phospho-TAK1 (Ser439). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.
DUSP1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 39 kDa, targeting to DUSP1. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.
Phospho-p38 (Thr180+Tyr182) Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Phospho-p38 (Thr180+Tyr182), with a predicted molecular weight of 41 kDa . Phospho-p38 (Thr180+Tyr182) Antibody can be used for WB, IHC-P, FC, ICC/IF, ELISA experiments in human, mouse backgrounds.
p38 Antibody (YA696) is a non-conjugated and Mouse origined monoclonal antibody about 41 kDa, targeting to p38 (5A1). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.
p38 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 41 kDa, targeting to p38. It can be used for WB,IP assays with tag free, in the background of Human.
MEKK2 Antibody (YA3215) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3215), targeting MEKK2, with a predicted molecular weight of 70 kDa (observed band size: 72 kDa). MEKK2 Antibody (YA3215) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.
MLK3 Antibody (YA3237) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3237), targeting MLK3, with a predicted molecular weight of 93 kDa (observed band size: 93 kDa). MLK3 Antibody (YA3237) can be used for WB, ICC/IF experiment in human background.
MEK5 Antibody (YA3140) is a non-conjugated IgG antibody, targeting MEK5, with a predicted molecular weight of 50 kDa. MEK5 Antibody (YA3140) can be used for WB, ICC/IF experiment in human background.
JNK3 Antibody (YA3150) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3150), targeting JNK3, with a predicted molecular weight of 53 kDa (observed band size: 53 kDa). JNK3 Antibody (YA3150) can be used for WB, ICC/IF, FC experiment in human, mouse, rat background.
ASK1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 155 kDa, targeting to ASK1. It can be used for WB,IHC-P,ICC/IF,FC assays with tag free, in the background of Human, Mouse.
Phospho-p38 (Thr180/Tyr182) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 41 kDa, targeting to Phospho-p38 (Thr180/Tyr182). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.
Phospho-ASK1 (Ser966) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 155 kDa, targeting to Phospho-ASK1 (Ser966). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.
MAP4K4/NIK Antibody (YA1123) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1123), targeting MAP4K4/NIK. MAP4K4/NIK Antibody (YA1123) can be used for IHC-P experiment in human background.
MEK2 Antibody (YA3059) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3059), targeting MEK2, with a predicted molecular weight of 44 kDa (observed band size: 44 kDa). MEK2 Antibody (YA3059) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse background.
Phospho-MEK1 (Ser298) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to Phospho-MEK1 (Ser298). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.
Phospho-MEK1 (Thr292) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to Phospho-MEK1 (Thr292). It can be used for WB assays with tag free, in the background of Mouse, Rat.
MAP2K6 Antibody (YA1088) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1088), targeting MAP2K6, with a predicted molecular weight of 37 kDa (observed band size: 40 kDa). MAP2K6 Antibody (YA1088) can be used for WB, IP experiment in human, rat background.
MEK7 Antibody (YA2647) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2647), targeting MEK7, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). MEK7 Antibody (YA2647) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
JNK Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to JNK. It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat, Hamster.
JNK1 (1A4) Antibody is a non-conjugated and Mouse origined monoclonal antibody about 48 kDa, targeting to JNK1 (1A4). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.
Phospho-MEK4 (Ser80) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44 kDa, targeting to Phospho-MEK4 (Ser80). It can be used for WB,IP assays with tag free, in the background of Human.
Phospho-JNK1 (Thr183/Tyr185) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to Phospho-JNK1 (Thr183/Tyr185). It can be used for WB,IP assays with tag free, in the background of Human, Rat.
MEKK3 Antibody (YA2633) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2633), targeting MEKK3, with a predicted molecular weight of 71 kDa (observed band size: 71 kDa). MEKK3 Antibody (YA2633) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
MAPKAP Kinase 2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 46 kDa, targeting to MAPKAP Kinase 2. It can be used for WB,IP assays with tag free, in the background of Human, Mouse,Rat.
1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE 18:1) is a lysophosphatidylethanolamine molecule involved in phospholipid metabolism, targeting cell membrane receptors (such as G protein-coupled receptors) to regulate cell signaling pathways. 1-oleoyl-sn-glycero-3-phosphoethanolamine may activatemitogen-activatedprotein kinase (MAPK) signaling, promote cell migration, regulate inflammatory responses and lipid metabolism, and has both pro-inflammatory and anti-inflammatory activities. 1-oleoyl-sn-glycero-3-phosphoethanolamine is mainly used in the screening of biomarkers for metabolic diseases (such as non-alcoholic fatty liver disease and obesity), as well as the study of the mechanism of lysophospholipids in cell membrane homeostasis and signal transduction .
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