SIN1 Antibody (YA6980)

Cat. No.: HY-P87297: Data Sheet User Guide for Antibodies
FAQs
Technical Support

SIN1 Antibody (YA6980) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SIN1.

For research use only. We do not sell to patients.

Size	Price	Stock
10 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

SIN1 Antibody (YA6980) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SIN1.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 59 kDa;

Observed band size: 65/75 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9BPZ7

Immunogen

Recombinant protein within human SIN1 aa 350-522.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000

Sensitivity	Endogenous	Purity	Protein G affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and A

Subcellular Localization：Cell membrane; Peripheral membrane protein; Endoplasmic reticulum membrane; Peripheral membrane protein; Early endosome membrane; Peripheral membrane protein; Late endosome membrane; Peripheral membrane protein; Lysosome membrane; Peripheral membrane protein; Golgi apparatus membrane; Peripheral membrane protein; Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasm, perinuclear region; Nucleus; Cell membrane; Nucleus; Cell membrane; Nucleus; Cell membrane; Cytoplasm, cytosol; Cyt

Subunit：Component of the mechanistic target of rapamycin complex 2 (mTORC2), consisting in two heterotretramers composed of MTOR, MLST8, RICTOR and MAPKAP1/SIN1 (PubMed:16919458, PubMed:16962653, PubMed:28264193, PubMed:29424687, PubMed:29567957, PubMed:33378666, PubMed:34519268, PubMed:35926713). The mTORC2 core complex associates with PRR5/PROTOR1 and/or PRR5L/PROTOR2 (PubMed:29424687). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin (PubMed:15467718). Interacts wi

Synonyms

MAPKAP 1 antibody; MAPKAP1 antibody; MEKK2 interacting protein 1 antibody; MGC2745 antibody; MIP 1 antibody; MIP1 antibody; Mitogen activated protein kinase associated protein 1 antibody; Mitogen-activated protein kinase 2-associated protein 1 antibody; mSIN1 antibody; OTTHUMP00000064207 antibody

Documentation

User Guide for Antibodies (1077 KB)