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peptidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dipeptidyl Peptidase (111) ADC Linker (1) Amino Acid Derivatives (2) Aminopeptidase (4) AMPK (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (9) Apoptosis (14) Aryl Hydrocarbon Receptor (1) Autophagy (1) Bacterial (15) Biochemical Assay Reagents (12) Carbonic Anhydrase (1) Cathepsin (2) ClpP (2) COX (1) Cytochrome P450 (1) Deubiquitinase (8) DNA Alkylator/Crosslinker (2) Drug Intermediate (3) E1/E2/E3 Enzyme (1) Elastase (3) Endogenous Metabolite (3) Estrogen Receptor/ERR (1) Ferroptosis (7) Fluorescent Dye (4) FXR (1) GCGR (3) GLP Receptor (1) Glutathione Peroxidase (2) Glycosidase (3) GPR119 (2) HIV (1) Insulin Receptor (2) Interleukin Related (4) Isotope-Labeled Compounds (9) JNK (2) Keap1-Nrf2 (1) Lipoxygenase (1) mGluR (2) Mitophagy (1) MMP (5) Neuropeptide Y Receptor (1) NF-κB (2) NOD-like Receptor (NLR) (3) Nuclear Hormone Receptor 4A/NR4A (1) Opioid Receptor (1) P-glycoprotein (2) p38 MAPK (2) Phospholipase (1) Potassium Channel (1) PPAR (1) Proteasome (2) Reactive Oxygen Species (ROS) (3) Reference Standards (10) Ser/Thr Protease (8) Small Interfering RNA (siRNA) (1) TNF Receptor (3) Toll-like Receptor (TLR) (1) γ-secretase (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (13) Endocrinology (3) Infection (18) Inflammation/Immunology (23) Metabolic Disease (90) Neurological Disease (15)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

203

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Dipeptidyl Peptidase Kallikrein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70017

Peptidase, microorganism Erepsin; peptidase (IMPa)	Others	Others
Peptidase (IMPa) (Erepsin) is catalytically active enzyme that cleaves peptide bonds in proteins and peptides by hydrolysis .

HY-P4464A

Ala-Phe-Pro-pNA TFA	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA TFA can be used to test tripeptidyl peptidase activity .

HY-P4470

Phe-Pro-Ala-pNA	Ser/Thr Protease	Cancer
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

HY-137199

Pro-Phe-Arg-AMC	Biochemical Assay Reagents	Others
Pro-Phe-Arg-AMC is a synthetic peptide substrate of Cysteine peptidases (CPs) .

HY-E70432

*Dipeptidyl peptidase* VII (human)**	Biochemical Assay Reagents	Others
Dipeptidyl peptidase VII (human) is a peptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-P4706

Boc-Ala-Ala-pNA	Amino Acid Derivatives	Others
Boc-Ala-Ala-pNA is a serine peptidase

HY-P4464

Ala-Phe-Pro-pNA	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA can be used to test tripeptidyl peptidase activity .

HY-W764737

Methylboronic acid pinacol ester-d3	Isotope-Labeled Compounds	Cancer
Methylboronic acid pinacol ester is an orally administered compound that inhibits the activity of peptidases and imidazole derivatives. Methylboronic acid pinacol ester is used as a medicinal preparation for cancer .

HY-E70434

*Dipeptidyl peptidase* III (human)**	Biochemical Assay Reagents	Others
Dipeptidyl peptidase III (human) is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70427

*Dipeptidyl peptidase* IX (human)**	Biochemical Assay Reagents	Others
Dipeptidyl peptidase IX (human) is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70397A

*Dipeptidyl Peptidase* IV, Porcine Kidney** DPP-IV, Porcine Kidney	Dipeptidyl Peptidase	Metabolic Disease
Dipeptidyl Peptidase IV, Porcine Kidney (DPP-IV, Porcine Kidney) is a serine aminopeptidase with multiple physiological roles. Dipeptidyl Peptidase IV, Porcine Kidney hydrolyses gastric inhibitory peptide (GIP) and glucagon-like peptide 1 (GLP-1), the most important insulin-releasing hormones (incretins) of the enteroinsular axis .

HY-P4488

H-Pro-Pro-Gln-OH	Dipeptidyl Peptidase	Others
H-Pro-Pro-Gln-OH is a oligopeptide with excellent *dipeptidyl peptidase-IV (DPP-IV)* inhibitory activity .

HY-137164A

Ala-Ala-Phe-AMC TFA	Fluorescent Dye	Others
Ala-Ala-Phe-AMC TFA is the TFA salt form for Ala-Ala-Phe-AMC. Ala-Ala-Phe-AMC TFA is a fluorogenic substrate, which is used to for tripeptidyl peptidase II (TPPII) activity determination .

HY-W010955

Z-Phe-Leu-OH NSC 334018	Biochemical Assay Reagents	Others
Z-Phe-Leu-OH (NSC 334018) is a substrate for carboxypeptidase Y (CPY). Z-Phe-Leu-OH is incubated with recombinant CPY to determine peptidase activity .

HY-E70005E

Collagenase, Type V 1 Publications Verification	MMP	Others
Collagenase, Type V is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type V breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-E70005A

Collagenase, Type I 5+ Cited Publications EC 3.4.24.3	MMP	Others
Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .

HY-E70005B

Collagenase, Type II 5+ Cited Publications	MMP	Others
Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-E70005C

Collagenase, Type III	MMP	Others
Collagenase, Type III is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type III breaksdown collagens1, 4, 9, 10, 14, fibronectin, MMP-9, gelatin, plasminogen, aggrecan,perlecan osteonectin

HY-14293

NVP-DPP728 dihydrochloride	Dipeptidyl Peptidase	Metabolic Disease
NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a K_i of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus .

HY-137870

γ-Glutamyl-β-naphthylamide gamma-Glutamyl-beta-naphthylamide	Biochemical Assay Reagents	Others
γ-Glutamyl-β-naphthylamide is a substrate for γ-glutamine peptidase. γ-Glutamyl-β-naphthylamide is specifically recognized and the peptide chain is cleaved. γ-Glutamyl-β-naphthylamide can be used to distinguish between gonococci and meningococci .

HY-E70005D

Collagenase IV, Clostridium histolytica 5+ Cited Publications Collagenase, Type IV	MMP	Others
Collagenase, Type IV (EC 3.4.24.3) is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin.

HY-W003592A

L-Orinithine lactam hydrochloride	Drug Intermediate	Others
L-Orinithine lactam hydrochloride is a synthetic intermediate. L-Orinithine lactam (hydrochloride) can be used in the synthesis of dipeptidyl peptidase 4 (DPP-4) inhibitors, as well as signaling peptides .

HY-14291

Vildagliptin 4 Publications Verification LAF237; NVP-LAF 237	Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease Cancer
Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291A

Vildagliptin dihydrate LAF237 dihydrate; NVP-LAF 237 dihydrate	Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease Cancer
Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291R

Vildagliptin (Standard) LAF237 (Standard); NVP-LAF 237 (Standard)	Reference Standards Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease
Vildagliptin (Standard) is the analytical standard of Vildagliptin. This product is intended for research and analytical applications. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-150070

Butabindide UCL-1397	Ser/Thr Protease	Neurological Disease
Butabindide (UCL-1397) is a potent, selective *tripeptidvl peptidase* II (TPP II) inhibitor with K_i** values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation .

HY-107759

Butabindide oxalate 1 Publications Verification UCL-1397 oxalate	Ser/Thr Protease	Neurological Disease
Butabindide (UCL-1397) oxalate is a potent, selective *tripeptidvl peptidase* II (TPP II) inhibitor with K_i** values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation .

HY-14291B

(2R)-Vildagliptin (2R)-LAF237; (2R)-NVP-LAF 237	Dipeptidyl Peptidase	Metabolic Disease
(2R)-Vildagliptin is the isomer of Vildagliptin (HY-14291), and can be used as an experimental control. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-W003592R

(S)-3-Aminopiperidin-2-one (Standard)	Drug Intermediate	Others
L-Orinithine lactam (Standard) is the analytical standard of L-Orinithine lactam. This product is intended for research and analytical applications. L-Orinithine lactam is a synthetic intermediate. L-Orinithine lactam can be used in the synthesis of dipeptidyl peptidase 4 (DPP-4) inhibitors, as well as signaling peptides .

HY-D2327

DPP-8/9 probe-1	Dipeptidyl Peptidase	Others
DPP-8/9 probe-1 (compound 20) is a fluorescent probe targeting Dipeptidyl Peptidase DPP8/9, which can be selectively labeled and visualized in vitro by fluorescence microscopy Active DPP8/9. DPP-8/9 probe-1 contains a nitrobenzoxadiazole (NBD) tag and has high affinity and selectivity for DPP8/9 over related S9 family members (IC₅₀ of 210 nM and 15 nM, respectively) .

HY-18522

AA26-9	Phospholipase	Metabolic Disease
AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines .

HY-129736A

P32/98	Dipeptidyl Peptidase	Metabolic Disease
P32/98 a potent inhibitor of *dipeptidyl peptidase* IV** with a K_i value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model .

HY-14291S2

Vildagliptin-13C5,15N LAF237-¹³C₅,¹⁵N; NVP-LAF 237-¹³C₅,¹⁵N	Isotope-Labeled Compounds Dipeptidyl Peptidase Apoptosis Ferroptosis	Metabolic Disease
Vildagliptin- ¹³C₅, ¹⁵N (LAF237- ¹³C₅, ¹⁵N; NVP-LAF 237- ¹³C₅, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-129736

P32/98 hemifumarate	Dipeptidyl Peptidase	Metabolic Disease
P32/98 hemifumarateis a potent inhibitor of *dipeptidyl peptidase* IV** with a K_i value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model .

HY-P4920

Mca-SEVNLDAEFK(Dnp)-NH2	Fluorescent Dye	Others
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .

HY-14292

NVP-DPP728	Dipeptidyl Peptidase	Metabolic Disease
NVP-DPP728 is a potent, reversible and nitrile-dependent *dipeptidyl peptidase* IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a K_i** of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes .

HY-129407

AAF-CMK TFA Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK; Tripeptidyl peptidase inhibitor II	Proteasome	Infection
AAF-CMK TFA (Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK) is a subtilisin-type serine peptidase that removes tripeptides from the free NH2 termini of oligopeptides. AAF-CMK TFA is an irreversible inhibitor of TPPII and is typically used at concentrations of 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at a concentration of 50 μM.

HY-10289

Carmegliptin RO-4876904	Dipeptidyl Peptidase P-glycoprotein	Cardiovascular Disease Metabolic Disease
Carmegliptin (RO-4876904) is an orally active, potent and long-acting *dipeptidyl peptidase* IV inhibitor. Carmegliptin is also a substrate of P-glycoprotein** that synergizes with Verapamil (HY-14275). Carmegliptin improves insulin sensitivity and reduces hepatic glucose production in hyperglycemic mice. Carmegliptin is promising for research of type 2 diabetes, hypertension and cardiovascular disease .

HY-P4460

AAA-pNA	Ser/Thr Protease	Cancer
AAA-pNA is a chromogenic substrate of *Tripeptidyl-peptidase* II*. AAA-pNA can be used to test Tripeptidyl-peptidase* II activity .

HY-151871

ICeD-2	Dipeptidyl Peptidase HIV	Infection
ICeD-2 is a inducer of cell death, can induce HIV-1 infected cell kill. ICeD-2-mediated HIV-1 infected cell kill is dependent on HIV-1 protease activity. ICeD-2 potently blocks hydrolysis of Gly-Pro-AMC by *dipeptidyl peptidase* DPP8 and DPP9**. ICeD-2 shows strong stabilization of DPP9 in PBMCs .

HY-P2543

Neuropeptide Y (3-36) (human, rat)	Neuropeptide Y Receptor	Metabolic Disease
Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor .

HY-10286A

Dutogliptin tartrate PHX-1149	Dipeptidyl Peptidase	Metabolic Disease
Dutogliptin tartrate (PHX-1149) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.

HY-176000

Sulphostin	Dipeptidyl Peptidase	Inflammation/Immunology Cancer
Sulphostin is a covalent inhibitor of *dipeptidyl peptidase* 4 (DPP4), dipeptidyl peptidase 9 (DPP9), and dipeptidyl peptidase 8 (DPP8) with IC₅₀** values of 79, 1392, 6930 nM, respectively. Sulphostin causes phosphosulfamate modification, irreversibly inhibits the enzyme activity. Sulphostin can be used for inflammation and cancer study .

HY-170800

DPP-4-IN-15	Dipeptidyl Peptidase	Others
DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC₅₀ of 8.24 μM .

HY-10286

Dutogliptin PHX-1149 free base	Dipeptidyl Peptidase	Metabolic Disease
Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.

HY-N10362

Ellipyrone B	Dipeptidyl Peptidase	Metabolic Disease
Ellipyrone B, an antihyperglycemic γ-pyrone enclosed macrocyclic polyketide, shows inhibition potential against dipeptidyl peptidase-4 (IC₅₀=0.48 mM) .

HY-112668

Retagliptin phosphate 1 Publications Verification SP2086 phosphate	Dipeptidyl Peptidase	Metabolic Disease
Retagliptin phosphate (SP2086 phosphate) is a selective, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* inhibitor. Retagliptin phosphate can be used for type 2 diabetes mellitus (T2DM) research .

HY-112668A

Retagliptin 1 Publications Verification SP2086	Dipeptidyl Peptidase	Metabolic Disease
Retagliptin (SP2086) is a selective, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* inhibitor. Retagliptin can be used for type 2 diabetes mellitus (T2DM) research .

HY-P2233

Globomycin	Bacterial Antibiotic	Infection
Globomycin is a lipopeptide antibiotic and a *signal peptidase* II (LspA)** inhibitor. Globomycin inhibits processing of the prolipoprotein by binding irreversibly to the peptidase. Globomycin has toxic for the mollicute *Spiroplasma melliferum* with a MIC in the range 6.25-12.5 μM .

HY-P4363

Suc-GPLGP-AMC	Biochemical Assay Reagents	Others
Suc-GPLGP-AMC is a peptide substrate of collagenase-like peptidases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-111174

Diprotin A 3 Publications Verification Ile-Pro-Ile	Microorganisms Source classification	Dipeptidyl Peptidase
Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV) .

HY-P1645

Papain Maximum Cited Publications 13 Publications Verification	Carica papaya L. Natural Products Classification of Application Fields Source classification Caricaceae Plants Inflammation/Immunology Disease Research Fields	Cathepsin
Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.

HY-N6584

Saikogenin A 1 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology	Dipeptidyl Peptidase
Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

HY-N10362

Ellipyrone B	Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Metabolic Disease Disease Research Fields	Dipeptidyl Peptidase
Ellipyrone B, an antihyperglycemic γ-pyrone enclosed macrocyclic polyketide, shows inhibition potential against dipeptidyl peptidase-4 (IC₅₀=0.48 mM) .

HY-N15105

Acetyl-L-Ieucyl-L-argininal	Natural Products Microorganisms Source classification	Dipeptidyl Peptidase
Acetyl-L-Ieucyl-L-argininal shows inhibition of peptidyl amin-peptidase III activity .

HY-113015R

Stearoylethanolamide (Standard)	Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Reference Standards
Saxagliptin (hydrochloride) (Standard) is the analytical standard of Saxagliptin (hydrochloride). This product is intended for research and analytical applications. Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin hydrochloride has the peotential for type 2 diabetes mellitus research .

HY-N10360

Ellipyrone A	Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Metabolic Disease Disease Research Fields	Dipeptidyl Peptidase
Ellipyrone A, a γ-pyrone enclosed macrocyclic poyketide, shows inhibition potential against dipeptidyl peptidase-4 (IC₅₀=0.35 mM). Ellipyrone A also has anti-carbolytic property against α-glucosidase (IC₅₀=0.74 mM) and α-amylase (IC₅₀=0.59 mM) .

HY-155704

Lyciumamide A	Lycium barbarum L. Source classification Phenols Polyphenols Solanaceae Plants	PPAR
DPP-IV-IN-5 is isolated from the fruits of Lycium barbarum. DPP-IV-IN-5 exerts moderate agonistic activities for peroxisome proliferator-activated receptor (PPARγ) with EC₅₀ values of 10.09 - 44.26 μM and also presents inhibitory activity on dipeptidyl peptidase-4 (DPPIV) with an IC₅₀ value of 47.13 μM .

HY-N15181

Fluostatin B	Monophenols Microorganisms Source classification Phenols	Dipeptidyl Peptidase
Fluostatin B is a dipeptidyl peptidase 3 (DPP-3) inhibitor with an IC₅₀ value of 24 µg/mL. Fluostatin B is a fluorenone, which is found in Streptomyces .

HY-N13981

Arylomycin B2	Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Arylomycin B2, an antibiotic, is a potent *signal peptidase* I (SPase I)** inhibitor. Arylomycin B2 has anti-Gram-positive bacteria activities .

HY-111174R

Diprotin A (Standard) Ile-Pro-Ile (Standard)	Microorganisms Source classification	Reference Standards Dipeptidyl Peptidase
Diprotin A (Standard) is the analytical standard of Diprotin A. This product is intended for research and analytical applications. Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1].

HY-N4069

Lupinalbin A Boeravinone L	Flavonoids Leguminosae Source classification Plants Other Flavonoids Lupinus albus Linn.	Estrogen Receptor/ERR Aryl Hydrocarbon Receptor Dipeptidyl Peptidase Glycosidase
Lupinalbin A (Boeravinone L) is a dipeptidyl peptidase 4 (DPP4) and α-glucosidase inhibitor with IC₅₀ values of 45.2 and 53.4 µM, respectively. Lupinalbin A exhibits antidiabetic activity .

HY-N7653

Azaleatin	Flavonols Flavonoids Classification of Application Fields Carthamus tinctorius L. Source classification Phenols Polyphenols Metabolic Disease Plants Compositae Disease Research Fields	Dipeptidyl Peptidase
Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity .

HY-N10064

Ficusonolide	Triterpenes other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	Others
Ficusonolide has significant antidiabetic activity with a possible mechanism of interaction with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.

HY-N8134

2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one	Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Dipeptidyl Peptidase
2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one is a natural product found in the leaves and stem bark of M. glabra. 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one displays binding affinities with *dipeptidyl peptidase-4 (DPP-4)* and α-Amylase. 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one has potential antidiabetic activities .

HY-N6079

Timosaponin A1	Liliaceae Classification of Application Fields Source classification Other Diseases Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids	Lipoxygenase Dipeptidyl Peptidase COX
Timosaponin A1, a natural steroidal saponin, is a 5-lipoxygenase (5-LO), COX-2, and *dipeptidyl peptidase* 4 (DPP-4) inhibitor with IC₅₀**s of 3.29 µM, 36.43 µM, and 33.25 µM, respectively .

HY-N12043

Bidenoside C	Coreopsis lanceolata L. Source classification Plants Compositae Saccharides Monosaccharides	Others
Bidenoside C (compound 10) is a polyacetylene glycoside (Polyacetylene Glycoside), which can be isolated from the flowers of Coreopsis lanceolata (Asteraceae) .

Cat. No.	Product Name	Chemical Structure

HY-14291S

Vildagliptin-d3
Vildagliptin-d₃ is the deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-W764737

Methylboronic acid pinacol ester-d3
Methylboronic acid pinacol ester is an orally administered compound that inhibits the activity of peptidases and imidazole derivatives. Methylboronic acid pinacol ester is used as a medicinal preparation for cancer .

HY-14291S2

Vildagliptin-13C5,15N
Vildagliptin- ¹³C₅, ¹⁵N (LAF237- ¹³C₅, ¹⁵N; NVP-LAF 237- ¹³C₅, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-10285S2

Saxagliptin-13C2
Saxagliptin- ¹³C₂ (BMS-477118- ¹³C₂) is ¹³C labeled Saxagliptin. Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* (K_i = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research .

HY-10285S

Saxagliptin-15N,d2 hydrochloride
Saxagliptin-15N,d2 Hydrochloride (BMS-477118-15N,d2 Hydrochloride) is the ¹⁵N and deuterium labeled isotope of Saxagliptin (HY-10285). Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* (K_i = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research .

HY-161447

USP1-IN-8
USP1-IN-8 (Compound 16) is an inhibitor for ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, with IC₅₀ ≤50 nM. USP1-IN-8 inhibits proliferation of MDA-MB-436 with IC₅₀ ≤50 nM .

HY-14291S1

Vildagliptin-d7
Vildagliptin-d₇ is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S5

Vildagliptin-d6
Vildagliptin-d₆ (LAF237-d₆ ) is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14877S1

Anagliptin-d7
Anagliptin-d₇ (SK-0403-d₇) is deuterium labeled Anagliptin. Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of *dipeptidyl peptidase* 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀**s of 68 nM and 60 nM, respectively .

HY-14806S2

Teneligliptin-d5

Teneligliptin-d₅ (MP-513-d₅) is deuterium labeled Teneligliptin. Teneligliptin (MP-513) hydrobromide hydrate is an orally active and selective dipeptidyl peptidase 4 (DPP-4) inhibitor (IC₅₀s: 0.37 and 0.29 nM for the human and rat DPP-4, respectively). Teneligliptin hydrobromide hydrate improves blood glucose levels and can be used in researches related to type 2 diabetes mellitus .

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