HAUSP/USP7 Antibody (YA5204)

HAUSP/USP7 Antibody (YA5204) is a mouse-derived and non-conjugated monoclonal antibody, targeting to HAUSP/USP7. It can be applicated for WB assays, in the background of human.

HAUSP is a hydrolase that deubiquitinates various target proteins, including ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5, and DAXX. In collaboration with DAXX, it prevents MDM2 self-ubiquitination and enhances MDM2's E3 ligase activity toward p53/TP53, promoting p53/TP53 ubiquitination and proteasomal degradation. HAUSP also deubiquitinates p53/TP53 to prevent its degradation and enhances p53/TP53-dependent transcriptional regulation, cell growth repression, and apoptosis. Additionally, HAUSP is involved in maintaining DNA methylation, transcription-coupled nucleotide excision repair (TC-NER), regulatory T-cell (Treg) suppressive capacity, circadian clock periodicity, neural progenitor cell maintenance, and WASH-dependent actin polymerization. During viral infections, HAUSP contributes to the stabilization and trans-activation capability of herpesvirus 1 ICP0/VMW110 and interacts with Epstein-Barr virus EBNA1 to promote PML protein ubiquitination and degradation.

Q93009

Observed band size: 135 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:200

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human HAUSP / USP7 protein fragments expressed in E.coli.