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Results for "

pan

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (15) Aldose Reductase (1) AMPK (5) Amyloid-β (2) Antibiotic (14) Apoptosis (46) Atg8/LC3 (1) ATM/ATR (1) Aurora Kinase (2) Autophagy (17) Bacterial (18) Bcl-2 Family (5) Bcr-Abl (4) Beta-lactamase (4) Biochemical Assay Reagents (1) Bombesin Receptor (2) Btk (2) c-Fms (1) c-Kit (2) c-Myc (1) Caspase (13) CDK (4) COX (1) CXCR (2) Cyclophilin (3) Dengue Virus (3) Deubiquitinase (2) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (6) E-Selectin (1) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (2) Early 2 Factor (E2F) (1) EGFR (16) Endogenous Metabolite (2) Epigenetic Reader Domain (15) ERK (1) Estrogen Receptor/ERR (2) FAP (1) FGFR (7) Filovirus (3) Flavivirus (6) FLT3 (3) Fluorescent Dye (1) GLUT (2) Glycosidase (1) HCN Channel (1) HCV (10) HCV Protease (3) HDAC (16) Hepatitis E Virus (HEV) (1) HIF/HIF Prolyl-Hydroxylase (5) Histone Acetyltransferase (1) Histone Demethylase (5) Histone Methyltransferase (1) HIV (1) HPV (3) HRASLS (1) HSP (2) IAP (3) iGluR (1) Influenza Virus (5) Insecticide (1) Integrin (2) Interleukin Related (1) IRAK (3) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (8) JAK (8) L-Selectin (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (2) LXR (1) mAChR (2) MAP3K (1) MARCKS (1) MDM-2/p53 (3) MEK (1) mGluR (1) Mitochondrial Metabolism (1) Mitophagy (3) MMP (2) Molecular Glues (2) Monoamine Oxidase (2) mTOR (10) NADPH Oxidase (2) Necroptosis (1) NF-κB (1) Notch (2) NTPDase (3) Nuclear Factor of activated T Cells (NFAT) (1) Opioid Receptor (2) Organoid (3) Oxidative Phosphorylation (1) P-selectin (4) p38 MAPK (1) PAK (2) Paraptosis (1) Parasite (3) PDGFR (1) PDHK (2) PDI (2) Phosphatase (4) Phosphodiesterase (PDE) (1) Phospholipase (1) PI3K (24) Pim (10) PIN1 (1) PKC (6) PKD (3) Polo-like Kinase (PLK) (1) PPAR (4) PROTAC Linkers (1) PROTACs (9) Proteasome (1) Protein Arginine Deiminase (1) Raf (18) RAR/RXR (3) Ras (37) Reactive Oxygen Species (2) Ribosomal S6 Kinase (RSK) (1) ROCK (2) Salt-inducible Kinase (SIK) (2) SARS-CoV (11) Ser/Thr Protease (1) SHP2 (2) Sirtuin (2) Small Interfering RNA (siRNA) (6) Src (2) SRPK (1) STAT (3) STING (2) TAM Receptor (2) TGF-β Receptor (1) Tie (1) Topoisomerase (3) Trk Receptor (8) VD/VDR (1) VEGFR (5) Virus Protease (5) WNK Kinase (1) YAP (4) YB-1 (1) YTHDF (1) γ-secretase (1)
By Research Areas:	Cancer (283) Cardiovascular Disease (5) Endocrinology (4) Infection (59) Inflammation/Immunology (48) Metabolic Disease (14) Neurological Disease (14)
Click Chemistry:	PROTAC Synthesis (1) Alkynes (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

381

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101295

Pan-RAS-IN-1 5+ Cited Publications	Ras	Cancer
Pan-RAS-IN-1 is a *pan-Ras* inhibitor that disrupts the interaction of Ras proteins and their effectors.

HY-163594

Pan-RAS-IN-3	Ras	Cancer
Pan-RAS-IN-3 is a *pan-Ras* inhibitor, and can be used for study of melanoma and acute myeloid leukaemia .

HY-148098

Pan KRas-IN-1 1 Publications Verification	Ras	Cancer
Pan KRas-IN-1 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors .

HY-164802

Pan-RAS-IN-7	Ras	Cancer
Pan-RAS-IN-7 (Compound D101) is a pan RAS inhibitor that can be used for the synthesis of ADCs. Pan-RAS-IN-7 can be utilized in cancer research .

HY-156555

pan-KRAS-IN-3	Ras	Cancer
pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor. pan-KRAS-IN-3 can be used for research of cancers . pan-KRAS-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-163489

pan-KRAS-IN-15	Ras	Cancer
pan-KRAS-IN-15 (compound 58) is a pan-KRAS inhibitor. pan-KRAS-IN-15 can be used in pancreatic cancer research .

HY-170785

pan-KRAS-IN-17	Ras	Cancer
pan-KRAS-IN-17 (Example 34) is an inhibitor of pan KRAS .

HY-163147

PAN endonuclease-IN-1	Influenza Virus	Infection
PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with K_d values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PA_N endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target .

HY-164645

pan-KRAS-IN-16	Ras	Cancer
pan-KRAS-IN-16 (Compound 3344) is an anti-RAS small molecule derived from an intracellular antibody fragment with pan-RAS-effector protein-protein interaction inhibitor properties. pan-KRAS-IN-16 binds to a hydrophobic pocket near to the effector-binding switch regions of RAS. pan-KRAS-IN-16 prevents endogenous RAS-dependent signaling in tumor cell lines .

HY-163299

pan-KRAS-IN-5	Ras Apoptosis	Cancer
pan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor by targeting 5′-UTR RNA G-quadruplexes (rG4s). pan-KRAS-IN-5 induces cell cycle arrest and promptes apoptosis in KRAS-driven cancer cells .

HY-158028

PAN endonuclease-IN-2	Influenza Virus	Infection
PAN endonuclease-IN-2 (compound T-31) is a *PA_N* endonuclease inhibitor (IC₅₀: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication .

HY-168671

pan-KRAS ligand 1	Ligands for Target Protein for PROTAC Ras	Cancer
pan-KRAS ligand 1 is a Ligand for Target Protein for PROTAC. pan-KRAS ligand 1 can be used for synthesis PROTAC pan-KRAS degrader 4 (HY-168669) .

HY-162439

pan-KRAS-IN-6	Ras	Cancer
pan-KRAS-IN-6 (compound 12) is a potent pan KRAS inhibitor with IC₅₀ values of 9.79 nM (Kras G12D) and 6.03 nM (Kras G12V) .

HY-163595

Pan-RAS-IN-4	Ras	Cancer
Pan-RAS-IN-4 (compound 2) is a potent inhibitor of RAS, with the IC₅₀ of ＜ 100 nM for KRAS G12D. Pan-RAS-IN-4 plays an important rile in cancer research .

HY-144676

pan-HER-IN-1	EGFR Apoptosis	Cancer
pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC₅₀ values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFR ^T790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities .

HY-144677

pan-HER-IN-2	EGFR Apoptosis	Cancer
pan-HER-IN-2 (Compound C6) is a reversible, orally active pan-HER inhibitor with IC₅₀ values of 0.72, 2.0, 8.2 and 75.1 nM against EGFR, HER4, EGFR ^T790M/L858R and HER2, respectively. pan-HER-IN-2 induces apoptosis and shows antitumor activities .

HY-158409

Pan-RAS-IN-2	Molecular Glues Ras Cyclophilin	Cancer
Pan-rasin-2 (compound 6A) is a molecular glues that targets RAS. Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor effects .

HY-144069

Pan-Trk-IN-3	Trk Receptor Apoptosis	Cancer
Pan-Trk-IN-3 (Compound 11g) is a potent inhibitor of pan-Trk and their drug-resistant mutants with IC₅₀ values of 2, 3, 2, 21, 26, 5, 7 and 6 nM against TrkA, TrkB, TrkC, TrkA ^G595R, TrkA ^G667C, TrkA ^G667S, TrkA ^F589L and TrkC ^G623R, respectively. Pan-Trk-IN-3 displays excellent antitumor activity and induces apoptosis .

HY-10082

Triapine 5+ Cited Publications 3-AP; pan-811; OCX191	DNA/RNA Synthesis	Cancer
Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.

HY-142452

Pan-RAF kinase inhibitor 1	Raf	Cancer
Pan-RAF kinase inhibitor 1 is a potent inhibitor of Pan-RAF kinase. Pan-RAF kinase inhibitor 1 regulates MAPK signaling by inhibiting RAF kinase, thereby exerting an effect on the proliferation of RAS-mutant tumor cells. Pan-RAF kinase inhibitor 1 has the potential for the research of cancer diseases (extracted from patent WO2021110141A1, compound 16B) .

HY-159912

pan-TEAD-IN-1	YAP	Cancer
pan-TEAD-IN-1 (Compound 3) is an orally active pan-TEAD inhibitor targeting the palmitoylation site of TEAD, disrupting its interaction with the coactivators YAP/TAZ, thereby suppressing the transcriptional upregulation of oncogenes (e.g., Ctgf and Cyr61) in the Hippo signaling pathway. pan-TEAD-IN-1 exhibits excellent activity with a luciferase IC₅₀ of 0.36 nM and an H226 cell IC₅₀ of 1.52 nM. It also shows favorable pharmacokinetics (AUC_0–∞ = 228.7 μg/mL·min, T_1/2 = 183.9 min). In TEAD-dependent xenograft mouse models, pan-TEAD-IN-1 significantly inhibited tumor growth, showing promise for research in TEAD-dependent cancers .

HY-163455

pan-HCN-IN-1	HCN Channel	Neurological Disease
pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC₅₀ of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices .

HY-156529

pan-KRAS-IN-2	Ras	Cancer
pan-KRAS-IN-2 (compound 6) is a pan inhibitor of with IC₅₀s ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D, respectively .

HY-162960

pan-KRAS degrader 1	Ras	Cancer
pan-KRAS degrader 1 (Compound 1) is a panKRAS degrader with a surface plasmon resonance (SPR) dissociation constant K_i value of 25 nM for KRAS ^G12V .pan-KRAS degrader 1 has antitumor activity .

HY-10082B

Triapine hydrochloride 3-AP hydrochloride; pan-811 hydrochloride; OCX191 hydrochloride	DNA/RNA Synthesis	Cancer
Triapine (hydrochloride) is the hydrochloride form of Triapine (HY-10082). Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer .

HY-169869

pan-Raf/RTK inhibitor 1	Raf	Cancer
Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC₅₀ values of 3.49 nM (BRaf ^V600E), 8.86 nM (ARaf), 5.78 nM (BRaf ^WT), and 1.65 nM (CRaf). Pan-Raf/RTK inhibitor 1 exhibits antiproliferative activities against various cancer cell lines and can be utilized in cancer research .

HY-RS10015

PAN3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PAN3 Human Pre-designed siRNA Set A contains three designed siRNAs for PAN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PAN3 Human Pre-designed siRNA Set A PAN3 Human Pre-designed siRNA Set A

HY-RS17294

Pan2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pan2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pan2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pan2 Mouse Pre-designed siRNA Set A Pan2 Mouse Pre-designed siRNA Set A

HY-RS24623

Pan3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pan3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pan3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pan3 Rat Pre-designed siRNA Set A Pan3 Rat Pre-designed siRNA Set A

HY-RS18148

Pan3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pan3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pan3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pan3 Mouse Pre-designed siRNA Set A Pan3 Mouse Pre-designed siRNA Set A

HY-RS10014

PAN2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PAN2 Human Pre-designed siRNA Set A contains three designed siRNAs for PAN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PAN2 Human Pre-designed siRNA Set A PAN2 Human Pre-designed siRNA Set A

HY-RS23749

Pan2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pan2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pan2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pan2 Rat Pre-designed siRNA Set A Pan2 Rat Pre-designed siRNA Set A

HY-162446

pan-KRAS-IN-13	Ras	Cancer
pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC₅₀s of 2.75 nM and 2.89 nM for G12D and G12V, respectively

HY-156528

pan-KRAS-IN-4	Ras	Cancer
pan-KRAS-IN-4 (compound 5) is a potent inhibitor of KRAS with IC₅₀s of 0.37 nM (Kras G12C), 0.19 nM (Kras G12V), respectively .

HY-173315

pan-BET/BD2-IN-1	Epigenetic Reader Domain	Cancer
pan-BET/BD2-IN-1 (compound 6b) is a selective extra-terminal (BET) protein inhibitor (BRDT-1 K_i = 1.05 μM and BRD4-1 K_i = 0.68 μM). pan-BET/BD2-IN-1 inhibits MM.1S cancer cell growth with an IC₅₀ of 2.6 μM .

HY-162536

Pan-RAS-IN-5	Molecular Glues Cyclophilin Ras	Cancer
Pan-RAS-IN-5 (compound 7A) is a molecular glues that can form a ternary complex with the proteins cyclophilin A (CYPA) and RAS (ON). The formation of the ternary complex can block the binding of RAS downstream of RAF and has anti-tumor effects .

HY-168012

Pan-RAS-IN-6	Ras Phosphatase	Cancer
Pan-RAS-IN-6 (compound 24) is an inhibitor targeting DUSP6, which reduces MAPK activation in the brain of the NCI-H1373-Luc model (DUSP6), at the same time, it shows significant tumor growth inhibition and tumor regression effects in the NSCLC brain metastasis mouse model. Pan-RAS-IN-6 shows high selectivity and strong inhibitory effects, especially in KRAS mutation-related signaling pathways, demonstrating varying inhibitory activity against different KRAS mutants and interacting proteins. The IC₅₀ values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively .

HY-162441

pan-KRAS-IN-8	Ras	Cancer
pan-KRAS-IN-8 (Compound 38) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC₅₀ of 0.07 and 0.18 nM, respectively .

HY-162440

pan-KRAS-IN-7	Ras	Cancer
pan-KRAS-IN-7 (Compound 25) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC₅₀ of 0.35 and 0.51 nM, respectively .

HY-162442

pan-KRAS-IN-9	Ras	Cancer
pan-KRAS-IN-9 (Compound 52) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC₅₀ of 0.24 and 0.30 nM, respectively .

HY-162443

pan-KRAS-IN-10	Ras	Cancer
pan-KRAS-IN-10 (Compound 58) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC₅₀ of 0.7 and 0.24 nM, respectively .

HY-10082S1

Triapine-d3 3-AP-d₃; pan-811-d₃; OCX191-d₃	Isotope-Labeled Compounds DNA/RNA Synthesis	Cancer
Triapine-d₃ (3-AP-d₃) is deuterium labeled Triapine. Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.

HY-144028

Pan-Trk-IN-2	Trk Receptor	Cancer
Compound cpd-1 is a small molecule Trks inhibitor with good antitumor activity .

HY-115781

DN401 panvotinib-401; pan-401	HSP	Cancer
DN401 is a potent TRAP1 inhibitor with an IC₅₀ of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC₅₀ of 698 nM). DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities .

HY-168347

TH152	Atg8/LC3	Others
TH152 is a reversible, pan ligand for LC3/GABARAP with a K_D of 2 µM. LC3/GABARAP is an autophagy associated protein .

HY-P10243

Ac-VAD-CMK	Caspase	Neurological Disease
Ac-VAD-CMK is a pan inhibitor for caspase 1 .

HY-176410

*IRAK1/4/pan-FLT3 Kinase-IN-2*	IRAK	Cancer
IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent IRAK1/4 and FLT3 dual inhibitor with IC₅₀s of 10, 0.7, and <0.5 nM. IRAK1/4/pan-FLT3 Kinase-IN-2 extends acute myeloid leukemia model mouse survival .

HY-159953

*IRAK1/4/pan-FLT3 Kinase-IN-1*	IRAK FLT3	Cancer
IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of IRAK1, IRAK4, and FLT3 kinases, with an IC₅₀ of 5 nM for IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. IRAK1/4/pan-FLT3 Kinase-IN-1 has good pharmacokinetic properties and shows promising potential for research in acute myeloid leukemia, with a survival prolongation effect comparable to that of Gilteritinib (HY-12432) .

HY-152078

Influenza virus-IN-6	Influenza Virus	Infection
Influenza virus-IN-6 (Compound 35) is a potent influenza *N-terminal domain of the polymerase acidic protein subunit (PA_N)* endonuclease inhibitor with an IC₅₀** of 0.20 μM .

HY-19760

I-BET282	Epigenetic Reader Domain	Inflammation/Immunology
I-BET282 is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282 shows pIC₅₀s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-10985

Marizomib Maximum Cited Publications 13 Publications Verification Salinosporamide A; NPI-0052	Marine natural products Source classification Marine microorganism	Proteasome
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, *pan-proteasome* inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

HY-N6794

10Z-Hymenialdisine (Z)-Hymenialdisine; Hymenialdisine	Alkaloids Structural Classification Pyrrole Alkaloids Animals Classification of Application Fields Marine natural products Source classification Sponge Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	AMPK VEGFR PDGFR
10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities .

HY-12597

Quisqualic acid L-Quisqualic acid	Structural Classification Ketones, Aldehydes, Acids Combretaceae Source classification Plants Quisqualis indica Linn.	iGluR mGluR
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica .

HY-W016420

Fosfomycin sodium 5+ Cited Publications MK-0955 sodium	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Bacterial Antibiotic
Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

HY-N0234

Bavachinin 3 Publications Verification 7-O-Methylbavachin; Bavachinin A	Structural Classification Monophenols Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Psoralea corylifolia L. Plants Inflammation/Immunology Disease Research Fields	Amyloid-β PPAR HIF/HIF Prolyl-Hydroxylase
Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC₅₀ value of 21.043 μM, 12.819 μM, and 0.622 μM to PPAR-α, RRAR-β/δ, and PPAR-γ, respectively. Bavachinin is an inhibitor of HIF-1α. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-γ. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity. .

HY-N14860

Milbemycin β3	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Milbemycin β3 is a macrolide antibiotic. Milbemycin β3 has insecticidal effects on agricultural harmful insects, pans, larvae, etc .

HY-N15090

Milbemycin α10	Structural Classification Microorganisms Antibiotics Source classification	Antibiotic Bacterial Insecticide
Milbemycin α10 is a macrolide antibiotic. Milbemycin α10 has insecticidal effects on agricultural harmful insects, pans, larvae, etc .

HY-N14900

Milbemycin β1	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Milbemycin β1 is a macrolide antibiotic. Milbemycin β1 has insecticidal effects on agricultural harmful insects, pans, larvae, etc .

HY-167884

PF-1367550	Structural Classification Alkaloids Aristolochia debilis Sieb. et Zucc. Source classification Plants Aristolochiaceae	JAK
PF-1367550 is a pan-JAK inhibitor. PF-1367550 can decrease the levels of release of CXCL9, CXCL10 and CXCL11 from primary airway epithelial cells .

HY-N15315

Triptriolide	Triterpenes Structural Classification Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants	Apoptosis MAP3K NF-κB
Triptriolide inhibits Puromycin aminonucleoside PAN (HY-15695)-induced apoptosis in mouse podocytes through regulation of Bcl-2 family proteins and inhibition of Caspase-3. Triptriolide promotes the cell survival, protects and restores the podocyte function through activation of TAK1-NF-κB signaling pathway and upregulation of podocin .

HY-N0234R

Bavachinin (Standard)	Structural Classification Monophenols Flavonoids Leguminosae Flavonones Source classification Phenols Psoralea corylifolia L. Plants	Amyloid-β PPAR HIF/HIF Prolyl-Hydroxylase
Bavachinin (Standard) is the analytical standard of Bavachinin. This product is intended for research and analytical applications. Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC₅₀ value of 21.043 μM, 12.819 μM, and 0.622 μM to PPAR-α, RRAR-β/δ, and PPAR-γ, respectively. Bavachinin is an inhibitor of HIF-1α. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-γ. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity. .

HY-124586

Streptonigrin 1 Publications Verification Bruneomycin	Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Infection Quinones Alkaloids Monophenols Microorganisms Phenols Benzene Quinones Disease Research Fields Cancer	Antibiotic Protein Arginine Deiminase E1/E2/E3 Enzyme HIF/HIF Prolyl-Hydroxylase MDM-2/p53 Apoptosis
Streptonigrin (Bruneomycin) is an orally active antibiotic and *pan-PAD* inhibitor, inhibiting PAD1, PAD2, PAD3 and PAD4 with IC₅₀ of 48.3 μM, 26.1 μM, 0.43 μM and 2.5 μM, respectively. Streptonigrin inhibits SENP1 (IC₅₀ of 0.518 μM) and reduces HIF1α. Streptonigrin increases p53 and Apoptosis. Streptonigrin shows antiviral activity against Rauscher murine leukemia virus. Streptonigrin has immunosuppressive effects. Streptonigrin has antitumor activity against osteosarcoma .

Cat. No.	Product Name	Chemical Structure

HY-10844S

Pretomanid-d4
Pretomanid-d₄ is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL .

HY-10082S1

Triapine-d3
Triapine-d₃ (3-AP-d₃) is deuterium labeled Triapine. Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.

HY-162445S

KRASG12D-IN-3-d3
pan-KRAS-IN-5-d₃ is deuterated labeled pan-KRAS-IN-5.

HY-124592

BMT-052
BMT-052 is a pan-genotypic hepatitis C (HCV) NS5B polymerase primer grip inhibitor .

HY-B1075AS

(Rac)-Fosfomycin (benzylamine)-13C3

(Rac)-Fosfomycin (benzylamine)- ¹³C₃ is the ¹³C labeled Fosfomycin . Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-12530S1

Velpatasvir-d3
Velpatasvir-d₃ (GS-5816-d₃) is deuterium labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 2.16 μM .

HY-W749691

(S)-Velpatasvir-13c,d3
(S)-Velpatasvir- ¹³C,d₃ ((S)-GS-5816- ¹³C,d₃) is ¹³C labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 2.16 μM .

HY-12530S3

Velpatasvir-13C,d3
Velpatasvir- ¹³C,d₃ (GS-5816- ¹³C,d₃) is ¹³C and deuterium labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 2.16 μM .

HY-131905S

BMS-986144
BMS-986144 is a third-generation, pan-genotype (GT) NS3/4A protease inhibitor. BMS-986144 inhibits HCV replicon with EC₅₀s of 2.3, 0.7, 1.0, 12, 8.0, and 5.8 nM for GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, and 1b D168V, respectively. BMS-986144 has the potential for the research of HCV infection .

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