2. Immunology/Inflammation
  3. Glycoprotein VI
  4. Anti-pan-Glypican Antibody (HS20)

Anti-pan-Glypican Antibody (HS20) is a kind of human IgG1 κ human antibody, targeting to human pan-Glypican. Anti-pan-Glypican Antibody (HS20) can neutralize the heparan sulfate (HS) chains on GPC3 thereby disrupting the Wnt3a-GPC3 interactions leading to blockade of the Wnt3a/β-catenin signaling. Anti-pan-Glypican Antibody (HS20) can be used for the research of cancer, such as hepatocellular carcinoma (HCC).

For research use only. We do not sell to patients.

Anti-pan-Glypican Antibody (HS20)

Anti-pan-Glypican Antibody (HS20) Chemical Structure

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Anti-pan-Glypican Antibody (HS20) Related Antibodies

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Description

Anti-pan-Glypican Antibody (HS20) is a kind of human IgG1 κ human antibody, targeting to human pan-Glypican. Anti-pan-Glypican Antibody (HS20) can neutralize the heparan sulfate (HS) chains on GPC3 thereby disrupting the Wnt3a-GPC3 interactions leading to blockade of the Wnt3a/β-catenin signaling. Anti-pan-Glypican Antibody (HS20) can be used for the research of cancer, such as hepatocellular carcinoma (HCC)[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

pan-Glypican
In Vitro

Anti-pan-Glypican Antibody (HS20) specifically recognizes the heparan sulfate (HS) chains on GPC3, also recognizes other glypicans (GPC1, GPC5 and GPC6)[1].
Anti-pan-Glypican Antibody (HS20) (10-50 μg/mL, 2 h) blocks blocks the interaction of Wnt3a and GPC3 and blocks Wnt3a-induced accumulation of active β-catenin in HEK293-SuperTopFlash cells[2].
Anti-pan-Glypican Antibody (HS20) (25-100 μg/mL, 2 h) inhibits Wnt-dependent cell proliferation in Hep3B and Huh-7 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-pan-Glypican Antibody (HS20) Related Antibodies
In Vivo

Anti-pan-Glypican Antibody (HS20) (20 mg/kg, i.v., three times a week) inhibits tumor growth in Hep3B/HepG2 tumor mice (BALB/c nu/nu nude mice)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hep3B/HepG2 tumor mice (4-6 weeks, female, BALB/c nu/nu nude mice)[1]
Dosage: 20 mg/kg
Administration: Intravenously injection, three times a week
Result: Inhibited tumor growth.
Had less β-catenin staining and contained fewer proliferating cells.
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-pan-Glypican Antibody (HS20)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-pan-Glypican Antibody (HS20) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-pan-Glypican Antibody (HS20)Glycoprotein VIGPVIGPC3GPC1GPC5GPC6Wnt3aHepatocellular carcinomaHep3BHuh-7HepG2Inhibitorinhibitorinhibit

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