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Results for "

synthase inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetolactate Synthase (ALS) (15) ATP Synthase (16) Cyclic GMP-AMP Synthase (14) Fatty Acid Synthase (FASN) (36) Glucosylceramide Synthase (GCS) (26) GSK-3 (27) NO Synthase (118) PGE synthase (27) Thymidylate Synthase (34) Acyltransferase (5) Adenosine Kinase (2) Adenylate Cyclase (2) Akt (1) Aminoacyl-tRNA Synthetase (1) Angiotensin Receptor (1) Antibiotic (33) Antifolate (12) Apoptosis (63) Arginase (2) Autophagy (19) Bacterial (64) Bcl-2 Family (3) Biochemical Assay Reagents (5) c-Kit (3) c-Myc (1) Calcium Channel (2) Caspase (2) CD38 (1) CDK (4) Claudin (1) Complement System (1) COX (7) Cuproptosis (2) Cytochrome P450 (10) Dengue Virus (1) Dihydrofolate reductase (DHFR) (2) Dihydroorotate Dehydrogenase (2) DNA Methyltransferase (2) DNA/RNA Synthesis (14) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (2) DYRK (1) EGFR (2) Endogenous Metabolite (52) ERK (2) Estrogen Receptor/ERR (2) Farnesyl Transferase (16) Flavivirus (1) Fungal (48) Glucocorticoid Receptor (2) Glutathione Peroxidase (1) Glutathione S-transferase (2) Glycosidase (1) Glycosyltransferase (1) Guanylate Cyclase (7) HCV (2) HDAC (1) Herbicide (6) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) HIV (1) HMG-CoA Reductase (HMGCR) (3) HSV (4) IFNAR (1) iGluR (2) IKK (2) Imidazoline Receptor (3) Influenza Virus (1) Insecticide (1) Interleukin Related (7) IRAK (1) Isotope-Labeled Compounds (35) JAK (1) JNK (2) Keap1-Nrf2 (1) LDLR (1) Ligands for Target Protein for PROTAC (1) Lipoxygenase (5) Microtubule/Tubulin (5) Mineralocorticoid Receptor (6) Mitochondrial Metabolism (3) MMP (2) Monoamine Oxidase (6) mTOR (3) NADPH Oxidase (1) Necroptosis (4) NF-κB (15) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (10) Orthopoxvirus (3) Oxidative Phosphorylation (2) p38 MAPK (3) Parasite (11) Phosphatase (2) Phosphodiesterase (PDE) (2) Phospholipase (9) Photosystem II (1) PI3K (2) PKA (1) PKC (4) PPAR (2) Progesterone Receptor (3) Prostaglandin Receptor (34) PTEN (2) Ras (2) Reactive Oxygen Species (ROS) (6) Reference Standards (44) RSV (2) SARS-CoV (6) Ser/Thr Protease (2) SOD (1) STAT (3) Stearoyl-CoA Desaturase (SCD) (1) Succinate Dehydrogenase (1) TNF Receptor (5) Tyrosinase (1) VEGFR (3) VKOR (2) Wnt (1)
By Research Areas:	Cancer (211) Cardiovascular Disease (64) Endocrinology (20) Infection (136) Inflammation/Immunology (148) Metabolic Disease (86) Neurological Disease (106)
Click Chemistry:	Alkynes (6)
Oligonucleotides:	Nucleoside Analogs (1) Uridine (1)

642

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: PGE synthase Thymidylate Synthase ATP Synthase Acetolactate Synthase (ALS) Glucosylceramide Synthase (GCS) NO Synthase Fatty Acid Synthase (FASN) Cyclic GMP-AMP Synthase Serpin GSK-3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W008821

1,7-Heptanediamine	DNA/RNA Synthesis	Others
1,7-Heptanediamine (C7) is a deoxyhypusine synthase inhibitor with IC₅₀ value of 4.5 μM .

HY-144270

Glucosylceramide synthase-IN-3	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active *glucosylceramide synthase* (GCS)** inhibitor with IC₅₀s of 16 nM for human GCS.Glucosylceramide synthase-IN-3 can be used for Gaucher's disease research .

HY-144266

TP-060 Glucosylceramide synthase-IN-1	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-1 (T-036), a chemical probe, a potent, brain-penetrant and orally active *glucosylceramide synthase* (GCS)** inhibitor with IC₅₀s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research .

HY-147277

Lorundrostat MT-4129	Cytochrome P450	Cardiovascular Disease
Lorundrostat (MT-4129) is an orally active aldosterone synthase inhibitor. Lorundrostat can be used in studies of high blood pressure .

HY-W775186

Tolprocarb	Fungal	Infection
Tolprocarb is an oomyces fungicide, which has a strong inhibitory effect on rice blast fungus Magnaporthe grisea by inhibiting polyketide synthase in melanin synthesis pathway .

HY-122795

Vanoxonin	Thymidylate Synthase	Others
Vanoxonin is an inhibitor of thymidylate synthase found in Saccharopolyspora hirsuta with an IC₅₀ value of 0.7 μg/mL .

HY-162804

*ATP synthase* inhibitor 3**	Bacterial ATP Synthase	Infection
ATP synthase inhibitor 3 (compound PT6) is an orally active inhibitor of mycobacterial F-ATP synthase (IC₅₀=0.788 μM). ATP synthase inhibitor 3 inhibits the growth of Mycobacterium tuberculosis H37Rv strain (ATCC-27294) in vitro and depletes intracellular ATP levels at an IC₅₀ value of 30μM .

HY-130673

L-NABE	NO Synthase	Cardiovascular Disease
L-NABE is a nitric oxide (NO) synthase inhibitor. L-NABE is also a potent endothelium dependent vasoconstrictor and inhibitor of relaxation .

HY-N1330

Rubranol	NO Synthase	Inflammation/Immunology
Rubranol is an inhibitor of NO Synthase. Rubranol inhibits LPS-induced NO production in activated macrophages with 74% inhibition .

HY-N9297

Oxyphyllenone A (+)-Oxyphyllenone A	NO Synthase	Inflammation/Immunology
Oxyphyllenone A is an inhibitor of NO Synthase. Oxyphyllenone A inhibits the NO production in lipopolysaccharide-activated macrophages with an IC₅₀ of 28 μM .

HY-156032

PIMPC	GSK-3	Neurological Disease
PIMPC is a compound with antioxidant and metal-chelating properties. PIMPC is a novel inhibitor of glycogen synthase kinase 3 (GSK-3). PIMPC has potential anti-Alzheimer's disease effect .

HY-144267

Glucosylceramide synthase-IN-2	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active *glucosylceramide synthase* (GCS)** inhibitor with IC₅₀s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research .

HY-155493

CYP19A1/CYP11B2-IN-1	Cytochrome P450	Cancer
CYP19A1/CYP11B2-IN-1 (Compound X21) is a potent and selective aromatase and aldosterone synthase dual inhibitor with IC₅₀s of 2.3 nM and 29 nM for aromatase (CYP19A1) and *aldosterone synthase* (CYP11B2)**, respectively. CYP19A1/CYP11B2-IN-1 has excellent antiproliferative and pro-apoptotic activity against the cancer cell. CYP19A1/CYP11B2-IN-1 can be used for research of breast cancer .

HY-178158

SQS-IN-1	Farnesyl Transferase Apoptosis DNA/RNA Synthesis	Cancer
SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer .

HY-149526

cGAS-IN-1	Cyclic GMP-AMP Synthase	Infection Inflammation/Immunology
cGAS-IN-1 (Compound C20) is a cyclic GMP-AMP synthase (cGAS) inhibitor with IC₅₀s of 2.28 μM (human cGAS, h-cGAS ^FL) and 1.44 μM (mouse cGAS, m-cGAS ^CD). cGAS-IN-1 can be used for the studies of autoimmune diseases and chronic inflammation .

HY-175828

DHPS-IN-2	DNA/RNA Synthesis	Cancer
DHPS-IN-2 is an allosteric deoxyhypusine synthase (DHPS) inhibitor with an IC₅₀ of 70 nM and a K_d of 26.4 μM. DHPS-IN-2 significantly suppresses melanoma cell migration and invasiveness in vitro and exhibits potent anti-tumor efficacy in an A375 cell zebrafish xenograft model. DHPS-IN-2 can be used for the study of melanoma .

HY-176779

Guanidino ethyl disulfide	NO Synthase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Guanidino ethyl disulfide (GED) (Compound 23) is a *NO Synthase* (NOS)** inhibitor with EC₅₀s of 110, 630 and 180  μM for iNOS, eNOS and bNOS, respectivly. Guanidino ethyl disulfide effectively inhibits nitrite production in J774.2 macrophages. Guanidino ethyl disulfide can be used for circulatory shock, inflammation and neurological diseases research .

HY-110354

UCM05 2 Publications Verification G28UCM	Fatty Acid Synthase (FASN) Bacterial Antibiotic	Infection Cancer
UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli.

HY-B1876

Nicosulfuron	Acetolactate Synthase (ALS) Photosystem II Fungal	Others
Nicosulfuron is efficient, harmless, antifungal and selective herbicide belonging to the sulfonylurea family. Nicosulfuron is also a photosynthetic system inhibitor and inhibits *acetolactate synthase* (ALS)** enzyme activity. Nicosulfuron degradation by Plectosphaerella cucumerina AR1 is glucose concentration dependent in planktonic lifestyle. Nicosulfuron enhances the glycolysis pathway and tricarboxylic acid cycle to improve the adaptability of sweet maize. Nicosulfuron reduces the synthesis of branched-chain amino acids (BCAAs), which is proming for maize cultivation .

HY-175198

Cs-2d	Acyltransferase Fungal	Infection
Cs-2d is a selective ceramide synthases Cer1 inhibitor. Cs-2d has potent inhibitory activity toward C. neoformans Cer1, while maintaining a low off-target effect on human hCerS1. Cs-2d has potent antifungal activity with the significant growth inhibition. Cs-2d can be used for invasive fungal infections research .

HY-151421

*Chitin synthase* inhibitor 11**	Fungal	Infection Cancer
Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC₅₀ value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs) .

HY-150686

*Chitin synthase* inhibitor 4**	Fungal	Infection
Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture .

HY-151420

*Chitin synthase* inhibitor 10**	Fungal	Infection Cancer
Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC₅₀ value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs) .

HY-151418

*Chitin synthase* inhibitor 8**	Fungal	Infection
Chitin synthase inhibitor 8 is a *chitin synthase* (CHS)** inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection .

HY-151419

*Chitin synthase* inhibitor 9**	Fungal	Infection
Chitin synthase inhibitor 9 is a *chitin synthase* (CHS)** inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 9 can be used in the research of fungi infection .

HY-151422

*Chitin synthase* inhibitor 12**	Fungal	Infection Cancer
Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC₅₀ value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs) .

HY-147721

Dihydropteroate synthase-IN-1	Bacterial	Infection
Dihydropteroate synthase-IN-1 (compound 5g) is a potent *dihydropteroate synthase* (DHPS)** inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material .

HY-151416

*Chitin synthase* inhibitor 6**	Fungal	Infection
Chitin synthase inhibitor 6 (compound 9b) is a potent *chitin synthase* (CHS)** inhibitor with an IC₅₀ value of 0.21 mM. Chitin synthase inhibitor 6 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 6 can be used in the research of fungi infection .

HY-151417

*Chitin synthase* inhibitor 7**	Fungal	Infection
Chitin synthase inhibitor 7 (compound 9c) is a potent *chitin synthase* (CHS)** inhibitor with an IC₅₀ value of 0.37 mM. Chitin synthase inhibitor 7 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 7 can be used in the research of fungi infection .

HY-155569

*Chitin synthase* inhibitor 13**	Fungal	Infection
Chitin synthase inhibitor 13 (compound 12g) is a non-competitive inhibitor of chitin synthase, with an IC₅₀ of 106.7 μM. Chitin synthase inhibitor 13 exhibits a broad-spectrum of antifungal activity .

HY-146239

EGFR/HER2/TS-IN-2	EGFR Thymidylate Synthase	Cancer
EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC₅₀ values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC₅₀ of 1.69 µM .

HY-151410

*Chitin synthase* inhibitor 5**	Fungal	Infection
Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC₅₀ value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal .

HY-149585

*Chitin synthase* inhibitor 14**	Fungal	Infection
Chitin synthase inhibitor 14 (compound 4n) is chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 14 has antifungal activity while possessed the potency against drug-resistant fungal variants .

HY-150983

*ATP synthase* inhibitor 2**	ATP Synthase Bacterial	Infection
ATP synthase inhibitor 2 is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC₅₀=10 μg/mL). ATP synthase inhibitor 2 can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .

HY-144391

*Chitin synthase* inhibitor 1**	Fungal Antibiotic	Inflammation/Immunology
Chitin synthase inhibitor 1 is a potent and selective *chitin synthase* (CHS)** inhibitor (IC₅₀=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants .

HY-16108A

Squalene synthase-IN-3 tripotassium	Farnesyl Transferase	Metabolic Disease
Squalene synthase-IN-3 tripotassium (Compound 1) is a potent squalene synthase inhibitor .

HY-139594

Polyketide synthase 13-IN-1	Bacterial	Infection Inflammation/Immunology
Polyketide synthase 13-IN-1 (compound 32) is a *polyketide synthase* 13** inhibitor .

HY-150983A

*ATP synthase* inhibitor 2 TFA**	ATP Synthase Bacterial	Infection
ATP synthase inhibitor 2 (Compound 22) TFA is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC₅₀=10 μg/mL). ATP synthase inhibitor 2 TFA can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .

HY-125458

Iromycin A	NO Synthase	Others
Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .

HY-124723

Gerfelin	Farnesyl Transferase	Cancer
Gerfelin inhibits geranylgeranyl diphosphate synthase (GGPP synthase) activity with an IC₅₀ of 3.5 μg/mL .

HY-44688

S.pombe lumazine synthase-IN-1	Bacterial Fungal	Infection
S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with K_i values of 243 μM and 9.6 μM for *Schizosaccharomyces pombe* and **Mycobacterium tuberculosis lumazine synthases**, respectively .

HY-150583

*Chitin synthase* inhibitor 2**	Fungal Antibiotic	Inflammation/Immunology
Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC₅₀ value of 0.09 mM and the K_i value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .

HY-U00432B

S-MTC acetate S-Methyl-L-thiocitrulline acetate	NO Synthase Endogenous Metabolite	Inflammation/Immunology
S-MTC acetate (S-Methyl-L-thiocitrulline acetate) acts as a powerful inhibitor of inducible nitric oxide synthase, favoring the inhibition of constitutive (neuronal) nitric oxide synthase over inducible (endothelial) nitric oxide synthase.

HY-126055

Hadacidin	Adenylate Cyclase	Others
Hadacidin is a competitive inhibitor of adenylate synthase. Hadacidin binds to the active site of adenylate synthase, competitively inhibiting L-aspartate binding. Hadacidin can be used in drug design, to help develop new inhibitors or activators to regulate adenylate synthase activity, and to play a role in the study of related diseases .

HY-126055A

Hadacidin sodium	Adenylate Cyclase	Others
Hadacidin sodium is a competitive inhibitor of adenylate synthase. Hadacidin sodium binds to the active site of adenylate synthase, competitively inhibiting L-aspartate binding. Hadacidin sodium can be used in drug design, to help develop new inhibitors or activators to regulate adenylate synthase activity, and to play a role in the study of related diseases .

HY-163131

Glucosylceramide synthase-IN-4	Glucosylceramide Synthase (GCS)	Neurological Disease
Glucosylceramide synthase-IN-4 (compound 12) is a potent *glucosylceramide synthase* (GCS)** inhibitor, with an IC₅₀ of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity .

HY-130356

5-trans U-46619	PGE synthase	Others
5-trans U-46619 is a PGE synthase inhibitor. At a concentration of 10 μM, 5-trans U-46619 inhibits PGE synthase by <20% .

HY-132809

Baxdrostat CIN-107	Mineralocorticoid Receptor	Endocrinology
Baxdrostat is a aldosterone synthase inhibitor .

HY-150584

*Chitin synthase* inhibitor 3**	Fungal	Infection
Chitin synthase inhibitor 3 (compound 2d) is a potent chitin synthase inhibitor with an IC₅₀ value of 0.16 mM, and MIC of 1 µg/mL against candida albicans. Antifungal activity .

HY-139595

Polyketide synthase 13-IN-2	Bacterial	Infection Inflammation/Immunology
Polyketide synthase 13-IN-2 (comp 42) is a *polyketide synthase* 13** inhibitor against Mycobacterium tuberculosis, with an MIC of 0.25 μg/mL .

Cat. No.	Product Name

HY-L089

Mitochondria-Targeted Compound Library

912 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 912 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

HY-L044

Nucleotide Compound Library

589 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 589 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Type

HY-D0145

7-Ethoxyresorufin 1 Publications Verification Resorufin ethyl ether	Chromogenic Substrates
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase .

HY-14536

Methylene Blue

20+ Cited Publications

Basic Blue 9; CI-52015; Methylthioninium chloride

Chromogenic Assays

Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene Blue is a photosensitizer and redox agent. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

HY-14536A

Methylene blue (purity≥70%)

Basic Blue 9 (purity≥70%); CI-52015 (purity≥70%); Methylthioninium chloride (purity≥70%)

Chromogenic Assays

Methylene blue (purity≥70%) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue (purity≥70%) is a vasopressor and is often used as a dye in several medical procedures. Methylene blue (purity≥70%) through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue (purity≥70%) is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue (purity≥70%) is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

HY-14536R

Methylene Blue (Standard)

Basic Blue 9 (Standard); CI-52015 (Standard); Methylthioninium chloride (Standard)

Chromogenic Assays

Methylene Blue (Standard) is the analytical standard of Methylene Blue. This product is intended for research and analytical applications. Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

Cat. No.	Product Name	Type

HY-134136A

Octanoyl coenzyme A lithium	Enzyme Substrates
Octanoyl coenzyme A lithium is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A lithium can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

HY-34748

3-Penten-2-one Ethylideneacetone; (3Z)-pent-3-en-2-one	Cell Assay Reagents
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .

HY-W037200

2,3,5-Tri-O-benzyl-D-ribose 2,3,5-Tri-O-benzyl-D-ribofuranose	Cell Assay Reagents
2,3,5-Tri-O-benzyl-D-ribose (Compound 1) is an effective inhibitor of Botrytis cinerea chitin synthase (CHS) with an IC₅₀ value of 1.8 μM. 2,3,5-Tri-O-benzyl-D-ribose exhibits antifungal activity and is able to inhibit the B. cinerea BD90 strain, with a MIC value of 190 μM .

HY-W251598B

Sodium bicarbonate, for molecular biology

Sodium hydrogen carbonate for molecular biology; Soda bicarbonate for molecular biology

Buffer Reagents

Sodium bicarbonate, for molecular biology (Sodium hydrogen carbonate for molecular biolog; Soda bicarbonate for molecular biolog) is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-W251598C

Sodium bicarbonate, for cell culture

Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture

Buffer Reagents

Sodium bicarbonate, for cell culture (Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture) is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate, for cell culture can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-134136

Octanoyl Coenzyme A	Enzyme Substrates
Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit *citrate synthase* (CS) and glutamate dehydrogenase (GDH) with IC₅₀** values of 0.4-1.6 mM .

HY-101410A

SDMA (p-hydroxyazobenzene-p′-sulfonate)

Symmetric dimethylarginine (p-hydroxyazobenzene-p′-sulfonate); NG,NG'-Dimethyl-L-arginine (p-hydroxyazobenzene-p′-sulfonate)

Biochemical Assay Reagents

SDMA p-hydroxyazobenzene-p′-sulfonate is the p-hydroxyazobenzene-p′-sulfonate salt form of SDMA (HY-101410). SDMA p-hydroxyazobenzene-p′-sulfonate is an endogenous inhibitor of nitric oxide synthase (NO synthase) activity. SDMA p-hydroxyazobenzene-p′-sulfonate is an activator for NF-κB, and promotes the expression of IL-6 and TNF-α. SDMA p-hydroxyazobenzene-p′-sulfonate is stable in serum and plasma, and can be used as a kidney biomarker of hepatic and renal dysfunction .

HY-135447

BM-531

Cell Assay Reagents

BM-531 is a dual-acting agent for thromboxane receptor (TXA2) antagonism and thromboxane synthase inhibition. BM-531 exerts anti-aggregatory effects on human citrated platelet-rich plasma (PRP), inhibiting Arachidonic acid (HY-109590A)-induced aggregation with an ED₁₀₀ of 0.125 μM and U-46619 (HY-108566)-induced aggregation with an ED₅₀ of 0.482 μM. BM-531 inhibits high-K ⁺-induced contraction of porcine uterine smooth muscle .

HY-W251598I

Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500

Sodium hydrogen carbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500

Buffer Reagents

Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

Cat. No.	Product Name	Target	Research Area

HY-W142119

α-Methyl-DL-aspartic acid 2 Publications Verification	Ser/Thr Protease	Neurological Disease
α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine .

HY-P1743

Acyl Carrier Protein (ACP) (65-74)	Peptides	Infection
Acyl Carrier Protein (ACP) (65-74) is a key coenzyme fragment of *fatty acid synthase* (FAS) and participates in fatty acid synthesis** as an acyl carrier. Acyl Carrier Protein (ACP) (65-74) mediates condensation, reduction and other cyclic reactions in fatty acid synthesis by covalently binding to acyl chains to form acyl-ACP intermediates, promoting acyl chain extension. Acyl Carrier Protein (ACP) (65-74) can regulate the synthesis ratio of saturated and unsaturated fatty acids. Acyl Carrier Protein (ACP) (65-74) can be used to study the mechanism of bacterial fatty acid synthesis and is a potential target for antibiotics (such as inhibiting the FAS system of pathogens) .

HY-P0117

Tat-NR2B9c Maximum Cited Publications 8 Publications Verification Tat-NR2Bct; NA-1	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .

HY-P0117A

Tat-NR2B9c TFA Maximum Cited Publications 8 Publications Verification Tat-NR2Bct TFA; NA-1 TFA	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .

HY-P0184

Camstatin	NO Synthase	Neurological Disease
Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase .

HY-P0184A

Camstatin TFA	NO Synthase	Neurological Disease
Camstatin TFA, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase .

HY-W142014

N,O-Didansyl-L-tyrosine cyclohexylammonium	Thymidylate Synthase	Cancer
N,O-Didansyl-L-tyrosine cyclohexylammonium is a potent selective thymidylate synthase (TS) inhibitor, acts on TS of Escherichia coli, Lactobacillus casei and human with the IC₅₀ values of 5.0, 3.4 and 119 μM, respectively .

HY-P10605

GSK3β-peptide	Akt GSK-3	Cancer
GSK3β-peptide is a substrate mimetic peptide of glycogen synthase kinase 3-β (GSK3-β) that can bind to the active site of GSK3-β and mimic the behavior of a real substrate. GSK3β-peptide can be used to develop substrate mimetic inhibitors of Akt as potential anticancer drugs .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126055

Hadacidin	Microorganisms Ketones, Aldehydes, Acids Source classification	Adenylate Cyclase
Hadacidin is a competitive inhibitor of adenylate synthase. Hadacidin binds to the active site of adenylate synthase, competitively inhibiting L-aspartate binding. Hadacidin can be used in drug design, to help develop new inhibitors or activators to regulate adenylate synthase activity, and to play a role in the study of related diseases .

HY-B1581A

L-Canavanine sulfate 2 Publications Verification	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	NO Synthase
L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.

HY-122795

Vanoxonin	Natural Products Microorganisms Source classification	Thymidylate Synthase
Vanoxonin is an inhibitor of thymidylate synthase found in Saccharopolyspora hirsuta with an IC₅₀ value of 0.7 μg/mL .

HY-N1330

Rubranol	Source classification Phenols Polyphenols Alnus formosana (Burkill) Makino Plants Betulaceae	NO Synthase
Rubranol is an inhibitor of NO Synthase. Rubranol inhibits LPS-induced NO production in activated macrophages with 74% inhibition .

HY-N9297

Oxyphyllenone A (+)-Oxyphyllenone A	Natural Products Source classification Plants Alpinia oxyphylla Miq. Zingiberaceae	NO Synthase
Oxyphyllenone A is an inhibitor of NO Synthase. Oxyphyllenone A inhibits the NO production in lipopolysaccharide-activated macrophages with an IC₅₀ of 28 μM .

HY-125458

Iromycin A	Natural Products Microorganisms Source classification	NO Synthase
Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .

HY-124723

Gerfelin	Microorganisms Antibiotics Source classification Other Antibiotics	Farnesyl Transferase
Gerfelin inhibits geranylgeranyl diphosphate synthase (GGPP synthase) activity with an IC₅₀ of 3.5 μg/mL .

HY-N13888

Schizostatin	Natural Products Microorganisms Source classification	Farnesyl Transferase
Schizostatin is a squalene synthase inhibitor with an IC₅₀ of 0.84 μM .

HY-N13912

Anticapsin	Natural Products Microorganisms Source classification	Fungal
Anticapsin is a glucosamine-6-phosphate synthase inhibitor with antifungal effects .

HY-N14162

Dihydroabikoviromycin	Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Dihydroabikoviromycin, a secondary metabolite of Streptomyces anulatus, is a polyketide synthase inhibitor .

HY-127029A

Umbelliprenin	Natural Products Source classification Umbelliferae Carpesium faberi C. Winkl. Plants	NO Synthase Lipoxygenase
Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as inducible nitric oxide synthase (NO synthase) .

HY-N0473

L-Tyrosine 5+ Cited Publications Tyrosine	Microorganisms Neurological Disease Classification of Application Fields Anti-aging Source classification Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-121061

Abikoviromycin	Microorganisms Antibiotics Source classification Other Antibiotics	Others
Abikoviromycin is an inhibitor of polyketide synthase PKS1 of C. lagenarium and can be isolated from Streptomyces .

HY-113637

Galbonolide A Rustmicin	Microorganisms Macrolide Antibiotics Antibiotics Source classification	Fungal
Galbonolide A (Rustmicin) is a potent antifungal agent.Galbonolide A inhibits inositol phosphoceramide synthase. Galbonolide A shows antifungal activity .

HY-113216

Asymmetric dimethylarginine 5 Publications Verification NG,NG-Dimethylarginine	Cardiovascular Disease Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite NO Synthase
Asymmetric dimethylarginine is an endogenous inhibitor of *nitric oxide synthase* (NOS)**, and functions as a marker of endothelial dysfunction in a number of pathological states.

HY-N13873

Saricandin	Natural Products Microorganisms Source classification	Fungal
Saricandin has weak antifungal activity. Saricandin inhibits glucan synthase with an ID₅₀ of 242.0 μg/mL .

HY-N12486

Isofalcarintriol	Natural Products Source classification Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Plants Umbelliferae	Keap1-Nrf2 ATP Synthase
Isofalcarintriol is a NRF2 activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-N6784

Oligomycin B	Microorganisms Antifungal Macrolide Antibiotics Antibiotics Source classification Disease Research	ATP Synthase Bacterial Apoptosis Antibiotic
Oligomycin B is an antibiotic isolated from marine Streptomyces, used as an eukaryotic ATP synthase inhibitor, induces apoptosis .

HY-N9814

Shanciol B	Pholidota imbricata Hook. Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	NO Synthase
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .

HY-125311

Zaragozic acid D	Microorganisms Ketones, Aldehydes, Acids Source classification	Farnesyl Transferase
Zaragozic acid D is a squalene synthase inhibitor. Zaragozic acid D also is a farnesyl-protein transferase (FPTase) inhibitor with an IC₅₀ value of 100 nM for bovine FPTase .

HY-116290

Zaragozic acid A 1 Publications Verification Squalestatin S1	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase. Zaragozic acid A is an inhibitor of acute hepatic cholesterol synthesis in mouse (IC₅₀ = 6 μM) .

HY-100313

YM-53601 free base	Alkaloids Carbazole Alkaloids	Farnesyl Transferase HCV
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-N14741

Lanopylin A2	Natural Products Microorganisms Source classification	Others
Lanopylin A2 can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with an IC₅₀ of 18 μM .

HY-N14743

Lanopylin B1	Natural Products Microorganisms Source classification	Others
Lanopylin B1 can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with an IC₅₀ of 33 μM .

HY-125324

Squalestatin 3	Natural Products Microorganisms Source classification	Endogenous Metabolite
Squalestatin 3 is a secondary metabolite, which can be isolated from Phoma. Squalestatin 3 is an inhibitor for squalene synthase with an IC₅₀ of 6 nM .

HY-N14744

Lanopylin B2	Natural Products Microorganisms Source classification	Others
Lanopylin B2 can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with an IC₅₀ of 41 μM .

HY-N14740

Lanopylin A1	Natural Products Microorganisms Source classification	Others
Lanopylin A1 can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with an IC₅₀ of 15 μM .

HY-N9891

12-Dehydrogingerdione 12-DHGD	Zingiber officinale Roscoe Monophenols Source classification Phenols Plants Zingiberaceae	NO Synthase Interleukin Related
12-Dehydrogingerdione is an inhibitor of NO Synthase. 12-Dehydrogingerdione signi?cantly inhibits LPS-stimulated production of NO, IL-6 and PGE2 in Raw 264.7 cells .

HY-142105R

2-Ethyl-2-hydroxybutanoic acid (Standard) 2-Ethyl-2-hydroxybutyric acid (Standard)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Eliglustat (Standard) is the analytical standard of Eliglustat. This product is intended for research and analytical applications. Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.

HY-101238

Agmatine sulfate 1 Publications Verification	Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Imidazoline Receptor NO Synthase Endogenous Metabolite
Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.

HY-B1581AR

L-Canavanine sulfate (Standard)	other families Ketones, Aldehydes, Acids Source classification Plants	NO Synthase
L-Canavanine (sulfate) (Standard) is the analytical standard of L-Canavanine (sulfate). This product is intended for research and analytical applications. L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.

HY-133098

Juncutol	Juncaceae Source classification Plants Juncus acutus L.	NO Synthase
Juncutol is a potent *inducible nitric oxide synthase* (iNOS)** inhibitor. Juncutol decreases the LPS (HY-D1056)-stimulated iNOS protein expression .

HY-N14161

Diazaquinomycin A	Microorganisms Antibiotics Source classification Other Antibiotics	Thymidylate Synthase Apoptosis
Diazaquinomycin A (DAQA), a diaza-anthracene antibiotic, is a thymidylate synthase inhibitor. Diazaquinomycin A (DAQA) induces DNA damage, cell cycle arrest, and apoptosis through cleaved-PARP .

HY-N8444

Triptoquinone A	Quinones Source classification Celastraceae Plants Tripterygium wilfordii Hook. f. Naphthalene Quinones	Interleukin Related
Triptoquinone A, an interleukin 1 inhibitor, inhibits endomycin (LPS) or interleukin (IL-1β)-promoted induction of nitric oxide synthase (NOS) in vascular smooth muscle, thereby inhibiting Arg-induced vascular relaxation .

HY-101410

SDMA 2 Publications Verification Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine	Human Gut Microbiota Metabolites Microorganisms Other disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite NO Synthase NF-κB
SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. SDMA, a novel kidney biomarker, permits earlier diagnosis of kidney disease than traditional creatinine testing.

HY-N6770

Curvularin (S)-Curvularin	Infection Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Phenols Polyphenols Disease Research Disease Research Fields	NO Synthase
Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced *nitric oxide synthase* (iNOS), with an IC₅₀** of 9.5 µM .

HY-133102

Dihydronarwedine Lycoraminone	Alkaloids Other Alkaloids Source classification Narcissus pseudonarcissus L. Plants Amaryllidaceae	GSK-3
Dihydronarwedine (Lycoraminone) is the alkaloid. Dihydronarwedine inhibits 39% activity of *glycogen synthase* kinase-3β (GSK-3β**) at a concentration of 10 μM .

HY-N6723

Fumonisin B2	Infection Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics	Acyltransferase
Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .

HY-N1382

Asperuloside 2 Publications Verification	Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Inflammation/Immunology Disease Research Fields Hedyotis diffusa Willd.	NO Synthase
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .

HY-N3602A

rel-Cleroindicin F Rengyolone	Natural Products Oleaceae Source classification Forsythia koreana (Rehder) Nakai Plants	TNF Receptor NF-κB NO Synthase
rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS (HY-D1056), thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production .

HY-N6782

Oligomycin Maximum Cited Publications 84 Publications Verification	Infection Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation ATP Synthase Fungal Antibiotic
Oligomycin, an antifungal antibiotic, is an inhibitor of H ⁺-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells .

HY-N11548

Inflexuside A	Terpenoids Labiatae Source classification Artemisia tanacetifolia L. Diterpenoids Plants	NO Synthase
Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages .

HY-N11544

Inflexuside B	Natural Products Labiatae Source classification Artemisia tanacetifolia L. Plants	NO Synthase
Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages .

HY-130043

11-O-Methylpseurotin A	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Complement System Bacterial Antibiotic
11-O-Methylpseurotin A is a compound of mixed polyketide synthase–nonribosomal peptide synthetase (PKS/NRPS) origin. 11-O-Methylpseurotin A selectively inhibits a Hof1 deletion strain .

HY-N0473R

L-Tyrosine (Standard) Tyrosine (Standard)	Microorganisms Source classification Amino acids Endogenous metabolite	Reference Standards Endogenous Metabolite
L-Tyrosine (Standard) is the analytical standard of L-Tyrosine. This product is intended for research and analytical applications. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-126871

Zaragozic acid D2	Microorganisms Ketones, Aldehydes, Acids Source classification	Farnesyl Transferase
Zaragozic acid D2 is the inhibitor for squalene synthase and Ras farnesyl-protein transferase (Ras FPTase), with IC₅₀ of 2 nM and 100 nM, respectively. Zaragozic acid D2 is potentially ameliorating hypercholesterolemia and Ras-induced cancer .

HY-A0210

Cerulenin 5+ Cited Publications	Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Metabolic Disease Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics	Fatty Acid Synthase (FASN) Fungal Apoptosis Antibiotic
Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies .

HY-N6730

Hydrolyzed Fumonisin B1 Aminopentol	Natural Products Microorganisms Source classification	Apoptosis
Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1 (HY-N6719). Hydrolyzed Fumonisin B1 can weakly inhibit ceramide synthase .

HY-N6893

Ergolide 3 Publications Verification	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Compositae Inflammation/Immunology Disease Research Fields Piptanthus nepalensis (Hook.) D. Don	NF-κB
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB .

HY-124199

Cephalochromin	Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC₅₀ of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL .

Cat. No.	Product Name	Chemical Structure

HY-101410S

SDMA-d6
SDMA-d₆ is the deuterium labeled SDMA. SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity .

HY-14885S1

Eliglustat-d4
Eliglustat-d₄ is the deuterium labeled Eliglustat. Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC₅₀ of 24 nM .

HY-110363

Miglustat-d9 hydrochloride
Miglustat-d₉ hydrochloride is the deuterium labeled Miglustat hydrochloride. Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1) .

HY-N0473S14

L-Tyrosine-d5
L-Tyrosine-d₅ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S8

L-Tyrosine-d2 1 Publications Verification
L-Tyrosine-d₂ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S15

L-Tyrosine-d3
L-Tyrosine-d₃ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S9

L-Tyrosine-d7 1 Publications Verification
L-Tyrosine-d₇ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-11101S

Alendronate-d6 sodium hydrate
Alendronate-d₆ sodium hydrate is deuterated labeled Alendronate sodium hydrate (HY-11101). Alendronate sodium hydrate is a farnesyl diphosphate synthase inhibitor with IC₅₀ of 460 nM.

HY-14885S

Eliglustat-d15 tartrate
Eliglustat-d₁₅ (tartrate) is the deuterium labeled Eliglustat. Eliglustat tartrate is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.

HY-113216S

Asymmetric dimethylarginine-d7 hydrochloride hydrate
Asymmetric dimethylarginine-d₇ (hydrochloride hydrate) is the deuterium labeled Asymmetric dimethylarginine. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a num

HY-N0473S12

L-Tyrosine-17O
L-Tyrosine- ¹⁷O is the ¹⁷O-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S1

L-Tyrosine-15N
L-Tyrosine- ¹⁵N is the ¹⁵N-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-17020S

Miglustat-d9
Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1) .

HY-N0473S10

L-Tyrosine-d2-1
L-Tyrosine-d₂-1 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S4

L-Tyrosine-13C
L-Tyrosine- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S13

L-Tyrosine-d2-2
L-Tyrosine-d₂-2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S

L-Tyrosine-d4
L-Tyrosine-d₄ is a deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex .

HY-N0473S2

L-Tyrosine-13C6
L-Tyrosine- ¹³C₆ is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S3

L-Tyrosine-13C9
L-Tyrosine- ¹³C₉ is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-14885S2

Eliglustat-d15
Eliglustat-d₁₅ (Genz 99067-d₁₅) is deuterium labeled Eliglustat. Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC₅₀ of 24 nM .

HY-N0473S5

L-Tyrosine-4-13C
L-Tyrosine-4- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S7

L-Tyrosine-1-13C
L-Tyrosine-1- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-B0631S

Alendronic acid-d6
Alendronic acid-d₆ is the deuterium labeled Alendronic acid. Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease .

HY-N0473S6

L-Tyrosine-3,5-13C2
L-Tyrosine-3,5- ¹³C₂ is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S16

L-Tyrosine-13C,15N
L-Tyrosine- ¹³C, ¹⁵N is the ¹³C and ¹⁵N labeled L-Tyrosine . L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex .

HY-N0473S11

L-Tyrosine-15N,d7
L-Tyrosine- ¹⁵N,d₇ is the deuterium and ¹⁵N-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-B0218S

Orlistat-d3
Orlistat-d3 is a deuterated labeled Orlistat . Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity .?Anti-atherosclerotic?effect .

HY-D0145S

7-Ethoxyresorufin-d5
7-Ethoxyresorufin-d₅ is deuterium labeled 7-Ethoxyresorufin. 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase .

HY-B1876S

Nicosulfuron-d6
Nicosulfuron-d₆ is the deuterium labeled Nicosulfuron . Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity .

HY-100427S

Imazamox-13C,d3
Imazamox- ¹³C,d₃ is the ¹³C- and deuterium labeled Imazamox. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death .

HY-10820S

Pemetrexed-d5
Pemetrexed-d₅ is the deuterium labeled Pemetrexed . Pemetrexed (LY231514) is an antifolate, the K_i values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .

HY-B0021S1

Doxifluridine-d3
Doxifluridine-d₃ is deuterated labeled Doxifluridine (HY-B0021). Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine *synthase* inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs .

HY-101238S

Agmatine-d8 sulfate
Agmatine-d₈ sulfate is a deuterium labeled Agmatine sulfate (HY-101238). Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor .

HY-10820AS

Pemetrexed-d5 disodium
Pemetrexed-d₅ disodium is the deuterium labeled Pemetrexed disodium. Pemetrexed disodium (LY231514 disodium) is an antifolate, the K_is of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .

HY-N6723S

Fumonisin B2-13C34
Fumonisin B2- ¹³C₃₄ is the ¹³C labeled Fumonisin B2 (HY-N6723) . Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .

HY-B0503S

2-Thiouracil-13C,15N2
2-Thiouracil- ¹³C, ¹⁵N₂ is the ¹³C, ¹⁵N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.

HY-A0061S

Trifluridine-13C,15N2
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine . Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity .

HY-W721637

Foramsulfuron-d6-1
Foramsulfuron-d₆-1 is the deuterium labeled Foramsulfuron (HY-W422402). Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids .

HY-14881S2

Bedaquiline impurity 2-d6
Bedaquiline impurity 2-d₆ is deuterium labeled Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-14881S1

(Rac)-Bedaquiline-d6
(Rac)-Bedaquiline-d₆ is the deuterium labeled Bedaquiline (HY-14881) . Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-W769288

Pemetrexed disodium-13C5
Pemetrexed disodium- ¹³C₅ (LY231514 disodium- ¹³C₅) is the ¹³C-labeled Pemetrexed disodium (HY-10820A). Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .

HY-N6719S

Fumonisin B1-13C34
Fumonisin B1- ¹³C₃₄ is the ¹³C labeled Fumonisin B1 (HY-N6719) . Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

HY-W747676

Glyphosate-13C

Glyphosate- ¹³C is the ¹³C-labeled Glyphosate (HY-B0863). Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .

HY-163712S

17-Epiestriol-d5-1

17-Epiestriol-d₅-1 is the deuterium labeled 17-Epiestriol (HY-163712). 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase .

HY-W654003

D-α-Hydroxyglutaric acid-d5 disodium

D-α-Hydroxyglutaric acid-d₅ disodium (Disodium (R)-2-hydroxyglutarate-d₅) is the deuterium labeled D-α-Hydroxyglutaric acid disodium (HY-100542). D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-W751179

Midostaurin-13C6

Midostaurin- ¹³C₆ (PKC412- ¹³C₆) is the ¹³C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-B0863S5

Glyphosate-13C,15N-1

Glyphosate- ¹³C, ¹⁵N-1 is the ¹³C- and ¹⁵N-labeled Glyphosate (HY-B0863). Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .

HY-B0084S4

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-W251598S

Bicarbonate-13C sodium

Bicarbonate- ¹³C sodium is the ¹³C-labeled Sodium bicarbonate (HY-Y0756). Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-134160S

5,6-Dihydro-5-Fluorouracil-13C,15N2

5,6-Dihydro-5-Fluorouracil- ¹³C, ¹⁵N₂ (5-DHFU- ¹³C, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled labeled 5,6-Dihydro-5-Fluorouracil (HY-134160). 5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC₅₀=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.

Cat. No.	Product Name		Classification

HY-13728

Plevitrexed ZD 9331; BGC9331		Alkynes
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent *thymidylate synthase* (TS)** inhibitor with a K_i of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-120293

CB30900		Alkynes
CB30900 is an inhibitor for thymidylate synthase with an IC₅₀ of 0.2 μM. CB30900 exhibits cytotoxicity in W1L2 with an IC₅₀ of 0.13 μM .

HY-10822

Idetrexed BGC 945; ONX-0801; CB 300945		Alkynes
Idetrexed (ONX 0801) is a *thymidylate synthase* (TS)** inhibitor with a K_i of 1.2 nM. Idetrexed can be specifically transported into α-folate receptor (α-FR)-overexpressing tumors, such as ovarian cancer .

HY-10822A

Idetrexed trisodium BGC 945 trisodium; ONX 0801 trisodium; CB 300945 trisodium		Alkynes
Idetrexed (ONX 0801) trisodium is a *thymidylate synthase* (TS)** inhibitor with a K_i of 1.2 nM. Idetrexed trisodium can be specifically transported into α-folate receptor (α-FR)-overexpressing tumors, such as ovarian cancer .

HY-13728B

(Rac)-Plevitrexed (Rac)-ZD 9331; (Rac)-BGC9331		Alkynes
(Rac)-Plevitrexed ((Rac)-ZD 9331; (Rac)-BGC9331)?is a racemate of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor. (Rac)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13728A

(R)-Plevitrexed (R)-ZD 9331; (R)-BGC9331		Alkynes
(R)-Plevitrexed ((R)-ZD 9331; (R)-BGC9331) is a less active enantiomer of Plevitrexed . Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor . (R)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-154508

FdUMP triethylammonium 2’-Deoxy-5-Fluorouridine 5’-phosphate triethylammonium		Nucleoside Analogs Uridine
FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.

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