2. Immunology/Inflammation Apoptosis
  3. NO Synthase Apoptosis
  4. 1400W Dihydrochloride (Standard)

1400W Dihydrochloride (Standard) 

Cat. No.: HY-18731R Purity: ≥98%
Handling Instructions Technical Support

1400W (Dihydrochloride) (Standard) is the analytical standard of 1400W (Dihydrochloride). This product is intended for research and analytical applications. 1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation.

For research use only. We do not sell to patients.

1400W Dihydrochloride (Standard) Chemical Structure

1400W Dihydrochloride (Standard) Chemical Structure

CAS No. : 214358-33-5

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Description

1400W (Dihydrochloride) (Standard) is the analytical standard of 1400W (Dihydrochloride). This product is intended for research and analytical applications. 1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation.

Molecular Weight

250.17

Formula

C10H17Cl2N3
CAS No.
SMILES

CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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1400W Dihydrochloride (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1400W Dihydrochloride (Standard)214358-33-5NO SynthaseApoptosisNitric oxide synthasesNOSiNOSneuronal NOSendothelial NOSmicroglialNOneuronal cellapoptosisInhibitorinhibitorinhibit

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