Search Result

Results for "

hydroxylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine β-hydroxylase (18) HIF/HIF Prolyl-Hydroxylase (55) Tryptophan Hydroxylase (22) Tyrosine Hydroxylase (5) 11β-HSD (3) 5 alpha Reductase (1) 5-HT Receptor (5) ADC Payload (1) Adrenergic Receptor (5) Akt (2) Amino Acid Derivatives (1) Androgen Receptor (1) Antibiotic (6) Apoptosis (10) Aryl Hydrocarbon Receptor (2) ATF6 (1) Autophagy (8) Bacterial (5) BCRP (1) Biochemical Assay Reagents (6) Calcium Channel (3) Cannabinoid Receptor (1) Collagen (2) COMT (1) COX (3) Cyclic GMP-AMP Synthase (3) Cytochrome P450 (44) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Dopamine Receptor (6) Drug Derivative (1) Drug Intermediate (3) Drug Metabolite (2) EGFR (2) Endogenous Metabolite (26) ERK (3) Estrogen Receptor/ERR (1) Farnesyl Transferase (1) Ferroptosis (3) Fungal (3) FXR (1) GABA Receptor (5) Herbicide (4) Histamine Receptor (1) Histone Demethylase (5) IGF-1R (2) Imidazoline Receptor (3) Influenza Virus (2) Interleukin Related (2) Isotope-Labeled Compounds (9) KMO (2) Mineralocorticoid Receptor (3) Mitochondrial Metabolism (5) MMP (4) Monoamine Oxidase (8) mTOR (3) nAChR (3) NF-κB (3) NO Synthase (3) Notch (1) Nuclear Hormone Receptor 4A/NR4A (3) OAT (2) Opioid Receptor (3) P-glycoprotein (1) p38 MAPK (2) Parasite (2) Phosphatase (1) Phospholipase (1) PI3K (2) PKA (3) PKC (2) PPAR (1) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (3) Reference Standards (21) Reverse Transcriptase (2) ROS Kinase (2) Somatostatin Receptor (1) Telomerase (2) TGF-beta/Smad (2) TGF-β Receptor (1) Thyroid Hormone Receptor (2) VD/VDR (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (76) Cardiovascular Disease (54) Endocrinology (12) Infection (18) Inflammation/Immunology (30) Metabolic Disease (61) Neurological Disease (49)
Click Chemistry:	Alkynes (3)

242

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Tryptophan Hydroxylase Tyrosine Hydroxylase Dopamine β-hydroxylase HIF/HIF Prolyl-Hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15183

*Collagen proline hydroxylase* inhibitor**	Collagen	Cancer
Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor, which can be used as an anti-fibrotic agent .

HY-144309

*Cholesterol 24-hydroxylase-IN-1*	Cytochrome P450	Neurological Disease
Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC₅₀=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier .

HY-149597

*Lysyl hydroxylase* 2-IN-1**	Monoamine Oxidase	Cancer
Lysyl hydroxylase 2-IN-1 (compound 12) is a selective *lysyl hydroxylase* 2 (LH2) Inhibitor with an IC₅₀** of ~300 nM. Lysyl hydroxylase 2-IN-1 demonstrates selectivity for LH2 over LH1 and LH3 .

HY-12347

Ro 61-8048 3 Publications Verification	KMO	Neurological Disease
Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC₅₀ of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations .

HY-149611

*Lysyl hydroxylase* 2-IN-2**	Monoamine Oxidase	Cancer
Lysyl hydroxylase 2-IN-2 (compound 13) is a potent *Lysyl hydroxylase* 2 (LH2) inhibitor, with the IC₅₀** of approximately 500 nM. Lysyl hydroxylase 2-IN-2 inhibits the migration in 344SQ WT cells, but not impedes the migration of the same cell line with an LH2 knockout cells .

HY-156799

*Cholesterol 24-hydroxylase-IN-2*	Cytochrome P450	Others
Cholesterol 24-hydroxylase-IN-2 is an inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1), with the IC₅₀ of 5.4 nM. Cholesterol 24-hydroxylase-IN-2 can be used in imaging of cholesterol 24-hydroxylase in mammals .

HY-E70520

*Salicylate hydroxylase, Microorganism*	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Salicylate hydroxylase, Microorganism (EC 1.14.13.1) is a flavin-dependent monooxygenase. Salicylate hydroxylase, Microorganism catalyzes the decarboxylative hydroxylation of salicylate into catechol in the naphthalene degradation pathway in Pseudomonas putida G7. Salicylate hydroxylase, Microorganism has potential biocatalytic applications .

HY-15182

*Collagen proline hydroxylase* inhibitor-1**	MMP	Cancer
Collagen proline hydroxylase inhibitor-1 is an antifibroproliferative agents.

HY-112441

*Prolyl Hydroxylase* inhibitor 1**	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC₅₀ of 62.23 nM . Antianemia agent .

HY-174332

*Cholesterol 24-hydroxylase-IN-3*	Cytochrome P450	Neurological Disease
Cholesterol 24-hydroxylase-IN-3 is an orally active, selective, and blood-brain barrier-penetrant CH24H inhibitor (IC₅₀ = 23 nM) belonging to 1,3-oxazole derivatives. Cholesterol 24-hydroxylase-IN-3 competitively inhibits CH24H enzyme activity by using the 1,3-oxazole nitrogen atom to coordinate the heme iron and the cyclopropyl group occupying the hydrophobic pocket. Cholesterol 24-hydroxylase-IN-3 can be used for research on epilepsy and other neurological diseases.

HY-N3550

Catalponol	Others	Cancer
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-125796

U-14624	Dopamine β-hydroxylase	Neurological Disease
U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes .

HY-12347R

Ro 61-8048 (Standard)	KMO	Neurological Disease
Ro 61-8048 (Standard) is the analytical standard of Ro 61-8048. This product is intended for research and analytical applications. Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations .

HY-E70329

*P-Hydroxybenzoate hydroxylase, native microorganism*	Endogenous Metabolite	Others
P-Hydroxybenzoate hydroxylase, native microorganism is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-W071686

6-Methyltetrahydropterin dihydrochloride	Biochemical Assay Reagents	Others
6-Methyltetrahydropterin (dihydrochloride) is a biochemical detection reagent that can be used in tyrosine hydroxylase activity assay .

HY-15641

FG-2216 5 Publications Verification IOX3; YM311	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
FG-2216 (IOX3) is a potent and orally active inhibitor of *HIF prolyl hydroxylase-2 (PHD2), with an IC₅₀* of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo .

HY-W092533

6-Fluorotryptophan	Tryptophan Hydroxylase	Neurological Disease
6-Fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes .

HY-A0124

Sapropterin (6R)-BH4; (6R)-Tetrahydro-L-biopterin	Endogenous Metabolite	Metabolic Disease
Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-141625

TRC160334	HIF/HIF Prolyl-Hydroxylase	Others
TRC160334 is a hypoxia-inducible factor (HIF) hydroxylase inhibitor. TRC160334 can be used for the research of ischemia/reperfusion injury .

HY-141625A

TRC160334 sodium	HIF/HIF Prolyl-Hydroxylase	Others
TRC160334 sodium is a hypoxia-inducible factor (HIF) hydroxylase inhibitor. TRC160334 sodium can be used for the research of ischemia/reperfusion injury .

HY-A0124A

Sapropterin dihydrochloride 1 Publications Verification (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride	Others	Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin also drives autoimmunity. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-15641R

FG-2216 (Standard)	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
FG-2216 (Standard) is the analytical standard of FG-2216. This product is intended for research and analytical applications. FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2), with an IC50 of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo .

HY-103227

Desidustat 2 Publications Verification ZYAN1	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Desidustat is an orally active HIF hydroxylase inhibitor. Desidustat can be used for the research of various disorders including anemia of different types and conditions associated with ischemia/hypoxia .

HY-W008452

H-Tyr(3-I)-OH	Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-A0124AR

Sapropterin dihydrochloride (Standard) (6R)-BH4 dihydrochloride (Standard); (6R)-Tetrahydro-L-biopterin dihydrochloride (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease Inflammation/Immunology
Sapropterin (dihydrochloride) (Standard) is the analytical standard of Sapropterin (dihydrochloride). This product is intended for research and analytical applications. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin also drives autoimmunity. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-103227R

Desidustat (Standard) ZYAN1 (Standard)	Reference Standards HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Desidustat (Standard) is the analytical standard of Desidustat. This product is intended for research and analytical applications. Desidustat is an orally active HIF hydroxylase inhibitor. Desidustat can be used for the research of various disorders including anemia of different types and conditions associated with ischemia/hypoxia .

HY-129079A

TFMB-(S)-2-HG 1 Publications Verification	DNA Methyltransferase Wnt β-catenin	Endocrinology Cancer
TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, β-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML) .

HY-33549

α-Methyl-p-tyrosine 1 Publications Verification	Tyrosine Hydroxylase	Neurological Disease Cancer
α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases .

HY-23460

p-Ethynylphenylalanine 1 Publications Verification 4-Ethynyl-L-phenylalanine	Tryptophan Hydroxylase	Neurological Disease
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of *tryptophan hydroxylase* (TPH), with a K_i** of 32.6 μM . p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-23460A

p-Ethynylphenylalanine hydrochloride 1 Publications Verification 4-Ethynyl-L-phenylalanine hydrochloride	Tryptophan Hydroxylase	Neurological Disease
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of *tryptophan hydroxylase* (TPH), with a K_i** of 32.6 μM . p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N2560

Senecionine Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin	Others	Metabolic Disease
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-131346

HIF-PHD-IN-1	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
HIF-PHD-IN-1 is an orally active inhibitor of *hypoxia-inducible factor prolyl hydroxylase* domain (HIF-PHD), with an IC₅₀ of 54 nM for hHIF-PHD2**. HIF-PHD-IN-1 is promising therapeutic agents for renal anemia .

HY-W013407

α-Methyltyrosine methyl ester hydrochloride 1 Publications Verification	Tyrosine Hydroxylase Thyroid Hormone Receptor	Neurological Disease
α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research .

HY-155009

PHD2-IN-1	HIF/HIF Prolyl-Hydroxylase	Others
PHD2-IN-1 is a potent and orally active inhibitor of *HIF prolyl hydroxylase* 2 (PHD2) with an IC₅₀** of 22.53 nM. PHD2-IN-1 can be used for anemia research .

HY-33549R

α-Methyl-p-tyrosine (Standard)	Tyrosine Hydroxylase	Neurological Disease Cancer
α-Methyl-p-tyrosine (Standard) is the analytical standard of α-Methyl-p-tyrosine. This product is intended for research and analytical applications. α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases .

HY-W762015

1,2,3,6,7,8-Hexachlorodibenzofuran 1,2,3,6,7,8-HxCDF	Cytochrome P450	Cancer
1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC₅₀s = 1.47 and 1.24 nM, respectively). 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (EC₅₀s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively) .

HY-N2560R

Senecionine (Standard) Senecionan-11,16-dione, 12-hydroxy- (Standard); Aureine (Standard); Senecionin (Standard)	Reference Standards Others	Metabolic Disease
Senecionine (Standard) is the analytical standard of Senecionine. This product is intended for research and analytical applications. Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-N4205R

Tetrahydropiperine (Standard)	Reference Standards Cytochrome P450	Cancer
Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine. This product is intended for research and analytical applications. Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM) .

HY-123468

HA-1004	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HY-123468A

HA-1004 di(hydrochloride)	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 dihydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 dihydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 dihydrochloride is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HY-W677684

Nurr1 agonist 2	Nuclear Hormone Receptor 4A/NR4A	Others
Nurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC₅₀: 0.07 μM). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a K_d value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression .

HY-157014

TPT-004	Tryptophan Hydroxylase	Cancer
TPT-004 is a selective and oraly active *tryptophan hydroxylases* (TPH) inhibitor with IC₅₀**s of 77 nM and 16 nM for TPH1 and TPH2, repsectively. TPT-004 exhibits exceptional selectivity for TPH1 compared with other members of the AAAH family. TPT-004 shows efficacy peripheral serotonin attenuation and colorectal tumor growth in mice^[1][2].

HY-129502

Fibrostatin C P-23924C	HIF/HIF Prolyl-Hydroxylase	Others
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery .

HY-44809

Izilendustat	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease Inflammation/Immunology
Izilendustat is a potent inhibitor of prolyl hydroxylase which can stabilize hypoxia inducible factor- 1 alpha (HIF- lα) and hypoxia inducible factor-2 (HIF-2). Izilendustat has the potential for researching diseases that relate to the body’s inmmune response like colitis and other inflammatory bowel diseases (extracted from patent WO2011057115A1 and WO2011057121A1) .

HY-103068

Diethyl-pythiDC 3 Publications Verification	MMP	Cancer
Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs).

HY-13041

LX-1031 1 Publications Verification	Tryptophan Hydroxylase	Neurological Disease
LX-1031 is a potent, orally available *tryptophan 5-hydroxylase* (TPH)** inhibitor that reduces serotonin (5-HT) synthesis peripherally.

HY-N1477

Dencichine Dencichin; ODAP	HIF/HIF Prolyl-Hydroxylase	Neurological Disease
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit *HIF-prolyl hydroxylase-2 (PHD-2)* activity.

HY-E70279

Phytanoyl-CoA	Biochemical Assay Reagents	Metabolic Disease
Phytanoyl-CoA is a coenzyme A derivative of phytanic acid that can serve as a substrate to be catalyzed by phytanoyl-CoA 2-hydroxylase (PAHX) into 2-hydroxyphytanoyl-CoA .

HY-106894

Lufironil HOE 077	Drug Metabolite	Others
Lufironil (HOE 077) is a prolyl 4-hydroxylase inhibitor. Lufironil is developed for the research of chronic liver diseases including alcoholic hepatitis and liver cirrhosis .

HY-121172

1,4-DPCA 1 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
1,4-DPCA, a potent *prolyl-4-hydroxylase* inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC₅₀ of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC₅₀ of 60 μM .

Cat. No.	Product Name

HY-L173

Anti-Ovarian Cancer Compound Library

2,391 compounds

Ovarian cancer is the most common cause of death in female genital malignancies, with the highest mortality rate in female genital malignancies. It is characterized by difficulty in detection in the early stage of the disease, high recurrence rate and poor prognosis. In fact, ovarian cancer includes many pathologic types. It is usually divided into epithelial ovarian cancer, malignant germ cell tumors and sex cord stromal tumors, of which epithelial ovarian cancer is the most dominant form. Clinical treatment of ovarian cancer prioritizes surgery combined with paclitaxel chemotherapy. However, due to the spread and drug resistance of tumor cells, the recurrence of ovarian cancer is high. In this case, combined with traditional methods, the development of new therapeutic agents can help to improve the treatment effect of ovarian cancer.

MCE designs a unique collection of 2,391 compounds with definite or potential anti-ovarian cancer activity, which mainly targeting the main targets of ovarian cancer such as PARP, ATM/ATR, VEGFR and HIF/HIF Prolyl-Hydroxylase, etc. It is an essential tool for development and research of anti-ovarian compounds.

HY-L045

Oxygen Sensing Compound Library

3,261 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 3,261 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Type

HY-W071686

6-Methyltetrahydropterin dihydrochloride	Biochemical Assay Reagents
6-Methyltetrahydropterin (dihydrochloride) is a biochemical detection reagent that can be used in tyrosine hydroxylase activity assay .

HY-W002291

p-Fluoro-L-phenylalanine 4-Fluoro-L-phenylalanine	Biochemical Assay Reagents
p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli (K_D=0.26 μM) .

Cat. No.	Product Name	Target	Research Area

HY-W013407

α-Methyltyrosine methyl ester hydrochloride 1 Publications Verification	Tyrosine Hydroxylase Thyroid Hormone Receptor	Neurological Disease
α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research .

HY-125586

β-Amanitin	DNA/RNA Synthesis ADC Payload	Cancer
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-W019599

4-Chloro-L-phenylalanine L-PCPA	5-HT Receptor Tryptophan Hydroxylase	Neurological Disease
4-Chloro-L-phenylalanine (L-PCPA) is a 5-HT biosynthesis inhibitor. 4-Chloro-L-phenylalanine is also a nonspecific antagonist of both isoforms of tryptophan hydroxylase (TPH1 and TPH2) .

HY-105055

Didemnin B	Peptides	Cancer
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-17365

Octreotide acetate 10+ Cited Publications SMS 201-995 acetate	Somatostatin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

HY-P4755

*N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide*	Peptides	Others
N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-158104

LPPM-8	ATF6	Others
LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

HY-P4817

Human PTH-(1-31)	Thyroid Hormone Receptor	Metabolic Disease
Human PTH-(1-31) is the 1-31 fragment of human PTH. Human PTH-(1-31) stimulates the release of cAMP and also is a weaker stimulator of the 25-hydroxyvitamin D-1α-hydroxylase. Human PTH-(1-31) induces bone formation without inducing bone resorption. Human PTH-(1-31) has the potential for the research of osteoporosis .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase	Inflammation/Immunology
Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD .

HY-125357

Ternatin	Peptides	Metabolic Disease
Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC₅₀ of 0.027 μM in 3T3-L1 adipocytes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0124A

Sapropterin dihydrochloride 1 Publications Verification (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Others
Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin also drives autoimmunity. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-W008452

H-Tyr(3-I)-OH	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-N2560

Senecionine Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin	Pterogyne nitens Tul. Alkaloids Pyrrole Alkaloids Classification of Application Fields Erinacea anthyllis Link Source classification Metabolic Disease Plants Compositae Disease Research Fields	Others
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-N1477

Dencichine Dencichin; ODAP	Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Source classification Amino acids Plants Araliaceae	HIF/HIF Prolyl-Hydroxylase
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit *HIF-prolyl hydroxylase-2 (PHD-2)* activity.

HY-N3550

Catalponol	Other Terpenoids Structural Classification Catalpa ovata G. Don Classification of Application Fields Terpenoids Source classification Bignoniaceae Plants Disease Research Fields Cancer	Others
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-N2560R

Senecionine (Standard) Senecionan-11,16-dione, 12-hydroxy- (Standard); Aureine (Standard); Senecionin (Standard)	Pterogyne nitens Tul. Alkaloids Structural Classification Pyrrole Alkaloids Erinacea anthyllis Link Source classification Plants Compositae	Reference Standards Others
Senecionine (Standard) is the analytical standard of Senecionine. This product is intended for research and analytical applications. Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-N4205R

Tetrahydropiperine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Piperaceae Plants Piper nigrum Linn.	Reference Standards Cytochrome P450
Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine. This product is intended for research and analytical applications. Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM) .

HY-129502

Fibrostatin C P-23924C	Structural Classification Natural Products Microorganisms Source classification	HIF/HIF Prolyl-Hydroxylase
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery .

HY-N6030

(Rac)-Dencichine (Rac)-Dencichin; (Rac)-ODAP	other families Classification of Application Fields Source classification Other Diseases Amino acids Plants Disease Research Fields	HIF/HIF Prolyl-Hydroxylase
(Rac)-Dencichine ((Rac)-Dencichin) is the racemate of Dencichin. Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity .

HY-N14330

Fibrostatin A	Quinones Structural Classification Microorganisms Source classification Naphthalene Quinones	HIF/HIF Prolyl-Hydroxylase
Fibrostatin A is a proline hydroxylase inhibitor found in Strptomyces catenulae .

HY-41404

Piperonylic acid 2H-1,3-benzodioxole-5-carboxylic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Piperaceae Plants Disease Research Fields Piper nigrum Linn.	Cytochrome P450 Interleukin Related EGFR IGF-1R
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-N14340

Fibrostatin F	Quinones Structural Classification Microorganisms Source classification Naphthalene Quinones	HIF/HIF Prolyl-Hydroxylase
Fibrostatin F is a proline hydroxylase inhibitor found in Strptomyces catenulae .

HY-N14332

Fibrostatin D	Quinones Structural Classification Microorganisms Source classification Naphthalene Quinones	HIF/HIF Prolyl-Hydroxylase
Fibrostatin D is a proline hydroxylase inhibitor found in Strptomyces catenulae .

HY-N14339

Fibrostatin E	Quinones Structural Classification Microorganisms Source classification Naphthalene Quinones	HIF/HIF Prolyl-Hydroxylase
Fibrostatin E is a proline hydroxylase inhibitor found in Strptomyces catenulae .

HY-N14331

Fibrostatin B	Quinones Structural Classification Microorganisms Source classification Naphthalene Quinones	HIF/HIF Prolyl-Hydroxylase
Fibrostatin B is a proline hydroxylase inhibitor found in Strptomyces catenulae .

HY-N15013

7-Deoxyloganin	Structural Classification Natural Products Caprifoliaceae Lonicera japonica Thunb. Source classification Plants	Biochemical Assay Reagents
7-Deoxyloganin serves as a biosynthetic precursor of Loganin (HY-N0512). 7-Deoxyloganin undergoes hydroxylation catalyzed by 7-deoxyloganin 7-hydroxylase, a cytochrome P450-dependent monooxygenase, to produce Loganin .

HY-N3769

Dipterocarpol	Infection Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Inflammation/Immunology Disease Research Fields	Others
Dipterocarpol is a dammarane-type triterpenoid. Dipterocarpol is substrate of the bacterial steroid-hydroxylase CYP106A2 .

HY-41404R

Piperonylic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Piperaceae Plants Piper nigrum Linn.	Cytochrome P450 Interleukin Related EGFR IGF-1R
Piperonylic acid (Standard) is the analytical standard of Piperonylic acid. This product is intended for research and analytical applications. Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-107383

Tetrahydrobiopterin 1 Publications Verification (Rac)-Sapropterin	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Disease markers Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder	NO Synthase Endogenous Metabolite
Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the *aromatic amino acid hydroxylases* enzymes and also acts as an essential cofactor for all nitric oxide synthase** (NOS) isoforms.

HY-113423

Tetrahydro-11-deoxycortisol Tetrahydrodeoxycortisol	Infection Classification of Application Fields Source classification Disease markers Other Diseases Endogenous metabolite Disease Research Fields Steroids Cancer	Endogenous Metabolite
Tetrahydro-11-deoxycortisol (Tetrahydrodeoxycortisol) is an endogenous metabolite present in Urine that can be used for the research of 11 Beta Hydroxylase Deficiency .

HY-116158

Oosponol	Structural Classification Monophenols Microorganisms Source classification Phenols	Dopamine β-hydroxylase Fungal
Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi .

HY-N2589

Isosaponarin	Structural Classification Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae	TGF-β Receptor Collagen
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and *prolyl 4-hydroxylase* (P4H)** proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .

HY-113038B

α-Hydroxyglutaric acid 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid	Structural Classification Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038A

α-Hydroxyglutaric acid disodium 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-N0453

Hypericin 5 Publications Verification	Structural Classification Natural Products Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Hyperlcurn perforatum L. Plants Disease Research Fields Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), *dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450*). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-W008226

Phloracetophenone 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone	Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Curcuma comosa Roxb. Infection other families Ketones, Aldehydes, Acids Phenols Polyphenols Disease Research Fields Zingiberaceae	Cytochrome P450 Bacterial Antibiotic
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .

HY-N7538

Dealanylalahopcin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial
Dealanylalahopcin is an antimicrobial agent that can be isolated from the culture filtrate of Streptomyces leucoderma subsp. ochraceus. Dealanylalahopcin can also be synthesized by enzymatic hydrolysis of alahopcin by microbial α-amino acid ester hydrolases. Dealanylalahopcin has weak antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibits moderate inhibition of collagen prolyl hydroxylase .

HY-105055

Didemnin B	Structural Classification Natural Products Animals Classification of Application Fields Marine natural products Source classification Other marine organisms Disease Research Fields Cancer	Others
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-N4205

Tetrahydropiperine	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Piperaceae Plants Disease Research Fields Piper nigrum Linn. Cancer	Cytochrome P450
Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs<、b>, and an activator of the PI3K/Akt/mTOR<、b> pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke .

HY-N3548

Catalpalactone	Structural Classification Natural Products Catalpa ovata G. Don Source classification Plants Bignoniaceae	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-N0453R

Hypericin (Standard) 5 Publications Verification	Structural Classification Natural Products Classification of Application Fields Guttiferae Source classification Phenols Hyperlcurn perforatum L. Plants Disease Research Fields Cancer	Reference Standards Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), *dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450*). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-113342

7-Ketocholesterol 2 Publications Verification	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	Endogenous Metabolite p38 MAPK
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-N11706

β-Cedrene (+)-β-Cedrene	Centaurea kotschyi (Boiss.) Hayek Structural Classification Natural Products Source classification Plants Compositae	Fungal
β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a K_i value of 1.6 μM .

HY-N7454

Anhydroerythromycin A	Infection Structural Classification Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields	Antibiotic Bacterial
Anhydroerythromycin A is a degradation product of the macrolide antibiotic erythromycin. Anhydroerythromycin A is formed via degradation of erythromycin in acidic aqueous solutions in vitro as well as in vivo. Anhydroerythromycin A is active against S. aureus and B. cereus in vitro (MICs = 12.5 and 6.25 μg/ml, respectively). Anhydroerythromycin A also inhibits steroid 6β-hydroxylase activity associated with the cytochrome P450 (CYP) isoform CYP3A in human liver microsomes.

HY-114464

11-Beta-hydroxyandrostenedione 4-Androsten-11β-ol-3,17-dione	Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite 11β-HSD
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism .

HY-N7454R

Anhydroerythromycin A (Standard)	Structural Classification Macrolide Antibiotics Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite	Reference Standards Antibiotic Bacterial
Anhydroerythromycin A (Standard) is the analytical standard of Anhydroerythromycin A. This product is intended for research and analytical applications. Anhydroerythromycin A is a degradation product of the macrolide antibiotic erythromycin. Anhydroerythromycin A is formed via degradation of erythromycin in acidic aqueous solutions in vitro as well as in vivo. Anhydroerythromycin A is active against S. aureus and B. cereus in vitro (MICs = 12.5 and 6.25 μg/ml, respectively). Anhydroerythromycin A also inhibits steroid 6β-hydroxylase activity associated with the cytochrome P450 (CYP) isoform CYP3A in human liver microsomes.

HY-B1232

Metyrapone Maximum Cited Publications 8 Publications Verification Su-4885	Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Cancer	Endogenous Metabolite Cytochrome P450 Autophagy
Metyrapone (Su-4885) is a potent and orally active *11β-hydroxylase* inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .

HY-B1232A

Metyrapone Tartrate Su-4885 Tartrate	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Cytochrome P450 Autophagy mTOR
Metyrapone (Su-4885) Tartrate is a potent and orally active *11β-hydroxylase* inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression .

HY-113342R

7-Ketocholesterol (Standard)	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	Endogenous Metabolite p38 MAPK
7-Ketocholesterol (Standard) is the analytical standard of 7-Ketocholesterol. This product is intended for research and analytical applications. 7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-N7512

Asimilobine	Infection Alkaloids Structural Classification Monophenols Classification of Application Fields Source classification Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Nymphaeaceae Disease Research Fields	Dopamine Receptor 5-HT Receptor Parasite
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity .

HY-B1232R

Metyrapone (Standard) Su-4885 (Standard)	Structural Classification Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	Reference Standards Endogenous Metabolite Cytochrome P450 Autophagy
Metyrapone (Standard) is the analytical standard of Metyrapone. This product is intended for research and analytical applications. Metyrapone (Su-4885) is a potent and orally active *11β-hydroxylase* inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .

HY-B0927

Hydrastine (-)-β-Hydrastine; (1R,9S)-β-Hydrastine	Structural Classification Alkaloids Piperidine Alkaloids Classification of Application Fields Ranunculaceae Other Diseases Plants Disease Research Fields	Tyrosine Hydroxylase Dopamine Receptor OAT
Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of *tyrosine hydroxylase* (TH), inhibiting dopamine biosynthesis (IC₅₀=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC₅₀=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis** when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .

HY-145751

*7α-Hydroxy-DHEA* 7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one	Structural Classification Source classification Endogenous metabolite Steroids	Cytochrome P450 Mitochondrial Metabolism
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma .

HY-N7204

4-Hydroxyderricin 1 Publications Verification	Structural Classification Chalcones Monophenols Flavonoids Phenols Umbelliferae Plants Ondetia linearis Benth.	Monoamine Oxidase Dopamine β-hydroxylase Apoptosis
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .

HY-101392

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-101392A

Harmane hydrochloride	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Rauwolfia canescens	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-B0927R

Hydrastine (Standard) (-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard)	Structural Classification Alkaloids Piperidine Alkaloids Ranunculaceae Plants	Reference Standards Tyrosine Hydroxylase Dopamine Receptor OAT
Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of *tyrosine hydroxylase* (TH), inhibiting dopamine biosynthesis (IC₅₀=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC₅₀=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis** when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .

HY-W016409

Ethyl 3,4-dihydroxybenzoate 1 Publications Verification Protocatechuic acid ethyl ester	Structural Classification Arachis hypogaea L. Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) NO Synthase Autophagy Apoptosis
Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive *prolyl hydroxylase* (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB** pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .

HY-128483

Fusaric acid	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor
Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-128483R

Fusaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor
Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

Species:	Human (19) Mouse (3)
Tag:	His (25) SUMO (3) Tag Free (5) Strep (1) Flag (1)
Source:	HEK293 (3) Sf9 insect cells (4) P. pastoris (1) E. coli (22)

Cat. No.	Compare	Product Name	Species	Source

HY-P73566

	*Tryptophan Hydroxylase* 1/TPH-1 Protein, Human (His)** TPH; TPH-1; TPRH; Tryptophan 5-hydroxylase 1; Tryptophan hydroxylase 1	Human	E. coli
	The tryptophan hydroxylase 1 (TPH-1) protein is key to serotonin biosynthesis, catalyzing the rate-limiting step: the oxidation of L-tryptophan to 5-hydroxy-L-tryptophan. This enzyme activity is critical for the synthesis of serotonin, a neurotransmitter that affects mood, sleep, and appetite. Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His) is the recombinant human-derived Tryptophan Hydroxylase 1/TPH-1 protein, expressed by E. coli , with N-His labeled tag.

HY-P76874

	*Dopamine beta-Hydroxylase* Protein, Human (HEK293, His)** Dopamine beta-hydroxylase; DBH; DOPBHY	Human	HEK293
	Dopamine beta-hydroxylase protein is an essential enzyme involved in the regulation of neurotransmitters. Its main function is to catalyze the hydroxylation of dopamine, converting it into norepinephrine (also known as norepinephrine). Dopamine beta-Hydroxylase Protein, Human (HEK293, His) is the recombinant human-derived Dopamine beta-Hydroxylase protein, expressed by HEK293 , with N-His labeled tag.

HY-P703327

	EGLN1 Protein, Human (His) C1orf12; PNAS-118; PNAS-137; Egl nine homolog 1; Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2); Prolyl hydroxylase domain-containing protein 2 (PHD2)	Human	E. coli
	EGLN1 Protein, Human (His) is the recombinant human-derived EGLN1, expressed by E. coli , with His labeled tag.

HY-P72184

	EPHX1 Protein, Human (His-SUMO) EPHX 1; EPHX; Ephx1; EPOX; Epoxide hydratase; Epoxide hydrolase 1; Epoxide hydrolase 1 microsomal xenobiotic; Epoxide hydroxylase 1; Epoxide hydroxylase 1 microsomal xenobiotic; HYEP_HUMAN; HYL1; MEH; Microsomal epoxide hydrolase	Human	E. coli
	The EPHX1 protein is an important biotransformation enzyme that hydrolyzes aromatic hydrocarbons and aliphatic epoxides by catalyzing the transaddition of water. This makes the epoxide less reactive and more water-soluble. EPHX1 Protein, Human (His-SUMO) is the recombinant human-derived EPHX1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P77565

	ASPH Protein, Mouse (His) Aspartate beta-hydroxylase; ASP beta-hydroxylase; Asph; Bah	Mouse	E. coli
	ASPH proteins exhibit enzymatic specificity by selectively hydroxylating aspartate (Asp) or asparagine (Asn) residues within specific epidermal growth factor-like (EGF) domains of the protein. This site-specific hydroxylation regulates post-translational modifications of EGF-containing proteins, potentially affecting their conformation, stability, or interactions. ASPH Protein, Mouse (His) is the recombinant mouse-derived ASPH protein, expressed by E. coli , with N-His labeled tag.

HY-P71375

	TPH2 Protein, Human (His) Tryptophan 5-hydroxylase 2; Neuronal Tryptophan hydroxylase; Tryptophan 5-Monooxygenase 2; TPH2; NTPH	Human	E. coli
	TPH2 Protein, an isozyme of tryptophan hydroxylase, is a member of the pterin-dependent aromatic acid hydroxylase family. TPH2 is selectively expressed only in the serotonergic neurons of the raphe nuclei and is a rate-limiting enzyme in the brain serotonin synthesis pathway. TPH2 plays a more prominent role in the 5-HT synthesis in the brain. Moreover, it is a key factor in maintaining normal serotonin transfer in the central nervous system. TPH2 Protein, Human (His) is the recombinant human-derived TPH2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72092

	ASPH Protein, Human (His-SUMO) ASPH; BAHAspartyl/asparaginyl beta-hydroxylase; EC 1.14.11.16; Aspartate beta-hydroxylase; ASP beta-hydroxylase; Peptide-aspartate beta-dioxygenase	Human	E. coli
	ASPH protein phosphorylates SPRTN, facilitating its chromatin recruitment and decreasing replication stress. ASPH activates the G2/M checkpoint by phosphorylating and inhibiting PABIR1/FAM122A, leading to serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity. ASPH Protein, Human (His-SUMO) is the recombinant human-derived ASPH protein, expressed by E. coli, with N-6*His, N-SUMO labeled tag.

HY-P702161

	*Hyoscyamine 6 beta-hydroxylase* Protein, Hyoscyamus niger** H6H; Hyoscyamine 6-dioxygenase; Hyoscyamine 6-beta-hydroxylase	Others	E. coli
	Hyoscyamine 6 beta-hydroxylase Protein, Hyoscyamus niger is the recombinant Hyoscyamine 6 beta-hydroxylase protein, expressed by E. coli, with tag free.

HY-P702105

	Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae Ectoine hydroxylase	Others	E. coli
	Phytyl-CoA dioxygenase (PHYH) is an enzyme involved in the alpha-oxidation of phytanic acid, a branched-chain fatty acid. PHYH catalyzes the conversion of phytyl-CoA to 2-hydroxyphytyl-CoA, initiating the degradation pathway. Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae is the recombinant Phytanoyl-CoA dioxygenase protein, expressed by E. coli , with tag free.

HY-P702106

	Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae (His) Ectoine hydroxylase	Others	E. coli
	Phytyl-CoA dioxygenase (PHYH) is an enzyme involved in the alpha-oxidation of phytanic acid, a branched-chain fatty acid. PHYH catalyzes the conversion of phytyl-CoA to 2-hydroxyphytyl-CoA, initiating the degradation pathway. Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae (His) is the recombinant Phytanoyl-CoA dioxygenase protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702798

	CYP7A1 Protein, Human (His) Cytochrome P450 7A1; 24-hydroxycholesterol 7-alpha-hydroxylase; CYPVII; Cholesterol 7-alpha-hydroxylase	Human	E. coli
	CYP7A1 Protein, Human (His) is the recombinant human-derived CYP7A1, expressed by E. coli , with N-6*His labeled tag.

HY-P704040

	KMO Protein, Human (His) dJ317G22.1; kmo; KMO_HUMAN; Kynurenine 3 hydroxylase; Kynurenine 3 monooxygenase (kynurenine 3 hydroxylase); Kynurenine 3 monooxygenase; Kynurenine 3-hydroxylase; Kynurenine 3-monooxygenase; RP1-317G22.1	Human	E. coli
	KMO Protein, Human (His) is the recombinant human-derived KMO protein, expressed by E. coli, with N-10*His tag.

HY-P73733

	PAH Protein, Human (D415N, sf9, His) Phenylalanine-4-hydroxylase; PAH	Human	Sf9 insect cells
	PAH protein is a key enzyme involved in amino acid metabolism. Its main function is to catalyze the hydroxylation of L-phenylalanine and convert it into L-tyrosine. PAH Protein, Human (D415N, sf9, His) is the recombinant human-derived PAH protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P702162

	ido Protein, Bacillus thuringiensis ido; L-isoleucine-4-hydroxylase; L-isoleucine dioxygenase; IDO	Others	E. coli
	IDO Protein, an enzyme, is involved in the conversion of tryptophan to kynurenine. Dysregulation of IDO Protein has been associated with immune suppression and tumor development. Targeting IDO Protein may present potential therapeutic approaches in cancer by modulating tryptophan metabolism, restoring immune responses, and inhibiting tumor growth. ido Protein, Bacillus thuringiensis is the recombinant ido protein, expressed by E. coli , with tag free.

HY-P701979

	kshB Protein, Mycobacterium tuberculosis hmp; 3-ketosteroid-9-alpha-monooxygenase; ferredoxin reductase component; 3-ketosteroid-9-alpha-hydroxylase; ferredoxin reductase component; KSH; Androsta-1; 4-diene-3; 17-dione 9-alpha-hydroxylase; Rieske-type oxygenase; RO	Others	E. coli
	The kshB protein significantly degrades cholesterol by catalyzing the introduction of the 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD), resulting in the 9OHADD intermediate. It is spontaneously converted to HSA through the cleavage of the B ring and aromatization of the A ring. kshB Protein, Mycobacterium tuberculosis is the recombinant kshB protein, expressed by E. coli , with tag free.

HY-P702163

	ido Protein, Bacillus thuringiensis (FLAG, His) ido; L-isoleucine-4-hydroxylase; L-isoleucine dioxygenase; IDO	Others	E. coli
	IDO Protein, an enzyme, is involved in the conversion of tryptophan to kynurenine. Dysregulation of IDO Protein has been associated with immune suppression and tumor development. Targeting IDO Protein may present potential therapeutic approaches in cancer by modulating tryptophan metabolism, restoring immune responses, and inhibiting tumor growth. ido Protein, Bacillus thuringiensis (FLAG, His) is the recombinant ido protein, expressed by E. coli , with N-6*His, N-Flag labeled tag.

HY-P701623

	KDM8 Protein, Human KDM8; Bifunctional peptidase and arginyl-hydroxylase JMJD5; JmjC domain-containing protein 5; Jumonji C domain-containing protein 5; L-arginine (3R)-hydroxylase KDM8	Human	E. coli
	The KDM8 protein is a multifunctional enzyme that acts as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. As an endopeptidase, it cleaves histone tails at methylated arginine or lysine residues, producing "tailless nucleosomes" that facilitate transcription elongation. KDM8 Protein, Human is the recombinant human-derived KDM8 protein, expressed by E. coli , with tag free.

HY-P701980

	kshB Protein, Mycobacterium tuberculosis (His) hmp; 3-ketosteroid-9-alpha-monooxygenase; ferredoxin reductase component; 3-ketosteroid-9-alpha-hydroxylase; ferredoxin reductase component; KSH; Androsta-1; 4-diene-3; 17-dione 9-alpha-hydroxylase; Rieske-type oxygenase; RO	Others	E. coli
	The kshB protein significantly degrades cholesterol by catalyzing the introduction of the 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD), resulting in the 9OHADD intermediate. It is spontaneously converted to HSA through the cleavage of the B ring and aromatization of the A ring. kshB Protein, Mycobacterium tuberculosis (His) is the recombinant kshB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701624

	KDM8 Protein, Human (His) KDM8; Bifunctional peptidase and arginyl-hydroxylase JMJD5; JmjC domain-containing protein 5; Jumonji C domain-containing protein 5; L-arginine (3R)-hydroxylase KDM8	Human	E. coli
	The KDM8 protein is a multifunctional enzyme that acts as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. As an endopeptidase, it cleaves histone tails at methylated arginine or lysine residues, producing "tailless nucleosomes" that facilitate transcription elongation. KDM8 Protein, Human (His) is the recombinant human-derived KDM8 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P73564

	*Tyrosine Hydroxylase* Protein, Human (sf9, His)** DYT14; TH; TYH dystonia 14; TYH; Tyrosine 3-monooxygenase	Human	Sf9 insect cells
	Tyrosine hydroxylase is a key enzyme in the biosynthesis of catecholamines, catalyzing the conversion of L-tyrosine into L-dopa, which is the rate-limiting step in the synthesis of dopamine, norepinephrine, and epinephrine. Tyrosine is hydroxylated using tetrahydrobiopterin and oxygen. Tyrosine Hydroxylase Protein, Human (sf9, His) is the recombinant human-derived Tyrosine Hydroxylase protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P73563A

	*Tyrosine Hydroxylase* Protein, Mouse (sf9, His)** DYT14; TH; TYH dystonia 14; TYH; Tyrosine 3-monooxygenase	Mouse	Sf9 insect cells
	Tyrosine hydroxylase protein is a key catalyst in the biosynthesis of catecholamines, including dopamine, norepinephrine, and epinephrine, and oversees the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa) , which is the critical and rate-limiting step pathway in synthesis.Tyrosine Hydroxylase Protein, Mouse (sf9, His) is the recombinant mouse-derived Tyrosine Hydroxylase protein, expressed by sf9 insect cells , with N-His labeled tag.

HY-P73563

	*Tyrosine Hydroxylase* Protein, Mouse (sf9, His, solution)** DYT14; TH; TYH dystonia 14; TYH; Tyrosine 3-monooxygenase	Mouse	Sf9 insect cells
	Tyrosine hydroxylase protein is a key catalyst in the biosynthesis of catecholamines, including dopamine, norepinephrine, and epinephrine, and oversees the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa) , which is the critical and rate-limiting step pathway in synthesis.Tyrosine Hydroxylase Protein, Mouse (sf9, His) is the recombinant mouse-derived Tyrosine Hydroxylase protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P703426

	kshA Protein, Mycobacterium tuberculosis (His, Strep) 3-ketosteroid-9-alpha-monooxygenase, oxygenase component; 3-ketosteroid-9-alpha-hydroxylase, oxygenase component; KSH; Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase; 1.14.15.30; Rieske-type oxygenase; RO; kshA; Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); Oxidoreductase;	Others	E. coli
	kshA Protein, Mycobacterium tuberculosis (His, Strep) is the recombinant kshA, expressed by E. coli , with Strep, His labeled tag. ,

HY-P71728

	CYP21A2 Protein, Human (P.pastoris, His) CYP21; 21 OHase; CYP21A2; Steroid 21 monooxygenase; Steroid 21-hydroxylase	Human	P. pastoris
	CYP21A2 Protein, a cytochrome P450 monooxygenase, crucially hydroxylates progesterone and 17alpha-hydroxyprogesterone at C-21, yielding vital intermediates for mineralocorticoid and glucocorticoid biosynthesis in adrenal steroidogenesis. This enzymatic process involves molecular oxygen, with NADPH providing essential electrons via cytochrome P450 reductase (CPR). CYP21A2 plays a pivotal role in regulating adrenal cortex hormone production. CYP21A2 Protein, Human (P.pastoris, His) is the recombinant human-derived CYP21A2 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P71917

	P4HB Protein, Human (His) 1 Publications Verification Cellular thyroid hormone binding protein; Cellular thyroid hormone-binding protein; Collagen prolyl 4 hydroxylase beta; Disulphide Isomerase; DSI; EC 5.3.4.1; ER protein 59; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1_HUMAN; PDIR; PHDB; PO4DB; PO4HB; PROHB; Protocollagen hydroxylase; Thbp	Human	E. coli
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (His) is the recombinant human-derived P4HB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70096

	COQ7 Protein, Human (HEK293, His) rHu5-demethoxyubiquinone hydroxylase, mitochondrial/COQ7, His; Ubiquinone Biosynthesis Protein COQ7 Homolog; Coenzyme Q Biosynthesis Protein 7 Homolog; Timing Protein Clk-1 Homolog; COQ7	Human	HEK293
	The COQ7 protein is a key enzyme in lipid A biosynthesis and catalyzes a key hydrolysis step involving UDP-3-O-myristoyl-N-acetylglucosamine. This activity leads to the formation of UDP-3-O-myristoylglucosamine and acetate, which is a decisive point in lipid A synthesis. COQ7 Protein, Human (HEK293, His) is the recombinant human-derived COQ7 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71087

	P4HB Protein, Human (HEK293, His) Protein Disulfide-Isomerase; PDI; Cellular Thyroid Hormone-Binding Protein; Prolyl 4-hydroxylase Subunit Beta; p55; P4HB; ERBA2L; PDI; PDIA1; PO4DB	Human	HEK293
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (HEK293, His) is the recombinant human-derived P4HB protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71203

	PHS Protein, Human (His) Pterin-4-Alpha-Carbinolamine Dehydratase; PHS; 4-Alpha-Hydroxy-Tetrahydropterin Dehydratase; Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha; DCoH; Dimerization Cofactor of HNF1; Phenylalanine hydroxylase-Stimulating Protein; Pterin Carbinolamine Dehy	Human	E. coli
	PHS protein is crucial in tetrahydrobiopterin biosynthesis and has the dual function of hindering the formation of 7-pterin and promoting quinone-BH2. It also acts as a coactivator of HNF1A-dependent transcription, affecting HNF1A dimerization and enhancing its activity. PHS Protein, Human (His) is the recombinant human-derived PHS protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72163

	CYP11B2 Protein, Human (His-SUMO) ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; C11B2_HUMAN; CYP11B2; CYPXIB2; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450 11B2; Cytochrome P450 11B2; mitochondrial; mitochondrial; P-450Aldo; P-450C18; Steroid 18-hydroxylase	Human	E. coli
	CYP11B2 Protein, a cytochrome P450 monooxygenase, synthesizes aldosterone, pivotal for salt and water balance, impacting blood pressure and cardiovascular health. Mechanistically, it orchestrates three oxidative reactions, forming aldosterone, utilizing molecular oxygen and a mitochondrial transfer system. Additionally, CYP11B2 may be involved in the androgen metabolic pathway, expanding its physiological roles. CYP11B2 Protein, Human (His-SUMO) is the recombinant human-derived CYP11B2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P72164

	CYP21A2 Protein, Human (His) CYP21; 21 OHase; 21-OHase; CA21H ; CAH1; CP21A_HUMAN; CPS1; CYP21A 2; CYP21A2; CYP21B; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 C21B; Cytochrome P450 XXI; Cytochrome P450; family 21; subfamily A; polypeptide 2; Cytochrome P450; subfamily XXIA steroid 21 hydroxylase;	Human	E. coli
	CYP21A2 Protein, a cytochrome P450 monooxygenase, crucially hydroxylates progesterone and 17alpha-hydroxyprogesterone at C-21, yielding vital intermediates for mineralocorticoid and glucocorticoid biosynthesis in adrenal steroidogenesis. This enzymatic process involves molecular oxygen, with NADPH providing essential electrons via cytochrome P450 reductase (CPR). CYP21A2 plays a pivotal role in regulating adrenal cortex hormone production. CYP21A2 Protein, Human (His) is the recombinant human-derived CYP21A2 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-13426S

Roxadustat-d5
Roxadustat-d₅ is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin .

HY-70013S

Abiraterone-d4
Abiraterone-d₄ is the deuterium labeled Abiraterone. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.

HY-113038AS

α-Hydroxyglutaric acid-13C5 disodium
α-Hydroxyglutaric acid- ¹³C₅ (sodium) is the ¹³C labeled α-Hydroxyglutaric acid sodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038AS1

α-Hydroxyglutaric acid-d4 disodium

α-Hydroxyglutaric acid-d₄ (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-B0859S1

MCPA-d3

MCPA-d₃ is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-101277S1

Vadadustat-13C6
Vadadustat- ¹³C₆ (PG-1016548- ¹³C₆) is ¹³C labeled Vadadustat. Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .

HY-144856S1

Sapropterin-d3
Sapropterin-d₃ ((6R)-BH4-d₃) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-W015007S

Metyrosine-13C9,15N,d7
Metyrosine- ¹³C₉, ¹⁵N,d₇ is the deuterium, ¹³C-, and 15-labeled Metyrosine. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .

HY-W008452S

H-Tyr(3-I)-OH-13C6
H-Tyr(3-I)-OH- ¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-W704805

Sodium 2-hydroxypentanedioate-2,3,3-d3

Sodium 2-hydroxypentanedioate-2,3,3-d₃ is the deuterium labeled α-Hydroxyglutaric acid disodium (HY-113038A). α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-114464S1

11-Beta-hydroxyandrostenedione-d7
11-Beta-hydroxyandrostenedione-d₇ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor

HY-B0859S

MCPA-13C8

MCPA- ¹³C₈ is the ¹³C-labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-114464S

11-Beta-hydroxyandrostenedione-d4
11-Beta-hydroxyandrostenedione-d₄ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor .

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-W778057

Ethyl 3,4-Dihydroxybenzoate-13C3

Ethyl 3,4-Dihydroxybenzoate- ¹³C₃ (Protocatechuic acid ethyl ester- ¹³C₃) is the ¹³C-labeled Ethyl 3,4-dihydroxybenzoate (HY-W016409). Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83004

	*Tryptophan 5 Hydroxylase* 1 Antibody (YA2749)** TPH1; MGC119994; TPRH; TRPH; Tryptophan 5-hydroxylase 1; Tryptophan hydroxylase	WB, IHC-P, IP	Human, Mouse, Rat
	Tryptophan 5 Hydroxylase 1 Antibody (YA2749) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2749), targeting Tryptophan 5 Hydroxylase 1, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). Tryptophan 5 Hydroxylase 1 Antibody (YA2749) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P80362

	*Tyrosine Hydroxylase* Antibody (YA023)**	WB, ICC/IF, IHC-P, FC, ICC/IF	Human, Mouse, Rat
	Tyrosine Hydroxylase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 59 kDa, targeting to Tyrosine Hydroxylase. It can be used for WB,ICC,IHC-P,FC,IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P82418

	Cytochrome P450 27A1 Antibody (YA2163) CYP27A1; CYP27; Sterol 26-hydroxylase; mitochondrial; 5-beta-cholestane-3-alpha; 7-alpha; 12-alpha-triol 27-hydroxylase; Cytochrome P-450C27/25; Cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Cytochrome P450 27A1 Antibody (YA2163) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2163), targeting Cytochrome P450 27A1, with a predicted molecular weight of 60 kDa (observed band size: 50 kDa). Cytochrome P450 27A1 Antibody (YA2163) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P85701

	*Tyrosine Hydroxylase* Antibody (YA5393)** Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Tyrosine Hydroxylase Antibody (YA5393) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Tyrosine Hydroxylase. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human, mouse, rat.

HY-P86075

	*Tyrosine Hydroxylase* Antibody (YA5767)** Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Tyrosine Hydroxylase Antibody (YA5767) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tyrosine Hydroxylase. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P87117

	TPH2 Antibody (YA6810) MGC138871 antibody; ADHD7 antibody; FLJ37295 antibody; MGC138872 antibody; Neuronal tryptophan hydroxylase antibody; NTPH antibody; TPH 2 antibody; Tph2 antibody; TPH2_HUMAN antibody; Tryptophan 5-hydroxylase 2 antibody; MGC138871 antibody; ADHD7 antibody; FLJ37295 antibody; MGC138872 antibody; Neuronal tryptophan hydroxylase antibody; NTPH antibody; TPH 2 antibody; Tph2 antibody; TPH2_HUMAN antibody; Tryptophan 5-hydroxylase 2 antibody; Tryptophan 5-monooxygenase 2 antibody; Tryptophan hydroxylase 2 antibody	WB, IHC-P, IHC-F, IP	Mouse, Rat

HY-P86857

	*Dopamine beta Hydroxylase* Antibody (YA6550)** dbh antibody; DBM antibody; Dopamine beta hydroxylase antibody; Dopamine beta monooxygenase antibody; Dopamine beta-hydroxylase (dopamine beta-monooxygenase) antibody; Dopamine beta-monooxygenase antibody; DOPO_HUMAN antibody; OTTHUMP00000022501 antibody; Soluble dopamine beta-hydroxylase antibody	WB	Human

HY-P82376

	Cytochrome P450 24A1 Antibody (YA2121) CYP24A1; CYP24; 1; 25-dihydroxyvitamin D(3) 24-hydroxylase; mitochondrial; 24-OHase; Vitamin D(3) 24-hydroxylase; Cytochrome P450 24A1; Cytochrome P450-CC24	WB	Human
	Cytochrome P450 24A1 Antibody (YA2121) is a non-conjugated IgG antibody, targeting Cytochrome P450 24A1, with a predicted molecular weight of 59 kDa (observed band size: 59 kDa). Cytochrome P450 24A1 Antibody (YA2121) can be used for WB experiment in human background.

HY-P81319

	JMJD6 Antibody (YA1064) JMJD6; KIAA0585; PTDSR; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-diox	WB, ICC/IF	Human
	JMJD6 Antibody (YA1064) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1064), targeting JMJD6, with a predicted molecular weight of 46 kDa (observed band size: 62 kDa). JMJD6 Antibody (YA1064) can be used for WB, ICC/IF experiment in human background.

HY-P85461

	PSR Antibody (YA5153) JMJD6; KIAA0585; PTDSR; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-diox	WB, ICC/IF	Human, Mouse, Rat, Bovine, Dog
	PSR Antibody (YA5153) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PSR. It can be applicated for WB, ICC/IF assays, in the background of human, mouse, rat, bovine, dog.

HY-P86297

	DOHH Antibody (YA5989) DOHH; HLRC1; Deoxyhypusine hydroxylase ; hDOHH; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase; HEAT-like repeat-containing protein 1;	WB, IP	Human
	DOHH Antibody (YA5989) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DOHH. It can be applicated for WB, IP assays, in the background of human.

HY-P85425

	CYP7A1 Antibody (YA5117) CYP7A1; CYP7; Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1	WB	Human, Golden hamster
	CYP7A1 Antibody (YA5117) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CYP7A1. It can be applicated for WB assays, in the background of human, golden hamster.

HY-P81244

	CYP2E1 Antibody (YA9212) CYP2E1; CYP2E; Cytochrome P450 2E1; 4-nitrophenol 2-hydroxylase; CYPIIE1; Cytochrome P450-J	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	CYP2E1 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting CYP2E1, with a predicted molecular weight of 57 kDa. CYP2E1 Antibody can be used for WB, IF-Tissue, IHC-P experiments in human, mouse, rat backgrounds.

HY-P86780

	Aldehyde Oxidase Antibody (YA6473) Aldehyde oxidase 1 antibody; AO antibody; AOH1 antibody; AOX 1 antibody; azaheterocycle hydroxylase antibody; EC 1.2.3.1 antibody	WB, IHC-P, FC	Human, Mouse, Rat

HY-P82557

	Cytochrome P450 2E1 Antibody (YA2302) CYP2E1; CYP2E; Cytochrome P450 2E1; 4-nitrophenol 2-hydroxylase; CYPIIE1; Cytochrome P450-J	WB	Human, Mouse, Rat
	Cytochrome P450 2E1 Antibody (YA2302) is a non-conjugated IgG antibody, targeting Cytochrome P450 2E1, with a predicted molecular weight of 57 kDa (observed band size: 57 kDa). Cytochrome P450 2E1 Antibody (YA2302) can be used for WB experiment in human, mouse, rat background.

HY-P83639

	Cytochrome P450 2D6 Antibody (YA3384) CYP2D6; CYP2DL1; Cytochrome P450 2D6; CYPIID6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase	WB, IHC-P, ICC/IF, FC	Human
	Cytochrome P450 2D6 Antibody (YA3384) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3384), targeting Cytochrome P450 2D6, with a predicted molecular weight of 56 kDa (observed band size: 50/55/80 kDa). Cytochrome P450 2D6 Antibody (YA3384) can be used for WB, IHC-P, ICC/IF, FC experiment in human background.

HY-P85566

	Cytochrome P450 17A1 Antibody (YA5258) 20 lyase; CP17A_HUMAN; CPT7; CYP17; CYP17A1; CYPXVII; Cytochrome P450 17A1; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 subfamily XVII; steroid 17 alpha hydroxylase; adrenal hyperplasia; Cytochrome p450 XVIIA1; Cytochrome P450-C17; Cytochrome P450c17; OTTHUMP00000020382; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase.	WB	Human
	Cytochrome P450 17A1 Antibody (YA5258) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CYP17A1. It can be applicated for WB assays, in the background of human.

HY-P85485

	JMJD6(N-term) Antibody (YA5177) Apoptotic cell clearance receptor; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; JMJD 6; JMJD6; JMJD6_HUMAN; Jumonji domain containing 6; Jumonji domain-containing protein 6; KIAA0585; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR; PSR; PTDSR 1; PTDSR; PTDSR1.	WB, ICC	Human
	JMJD6(N-term) Antibody (YA5177) is a mouse-derived and non-conjugated monoclonal antibody, targeting to JMJD6 (N-term). It can be applicated for WB, ICC assays, in the background of human.

HY-P81245

	CYP1A2 Antibody (YA3505) Cytochrome P450 1A2; cytochrome P450, family 1, subfamily a, polypeptide 2; Cytochrome P450 family 1 polypeptide 2; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2; Cyp1a2; CYPD45; P-450d; RATCYPD45; CP12; CP 12; P3-450; Aryl hydrocarbon hydroxylase; Dioxin inducable P3 45; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P450 4; P450 form 4; P450 P3; P450(PA); Xenobiotic monooxygenase; P450 1A2.	WB, ICC/IF, FC	Human
	CYP1A2 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting CYP1A2, with a predicted molecular weight of 58 kDa. CYP1A2 Antibody can be used for WB,ICC/IF,FC experiments in human backgrounds.