2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Autophagy Apoptosis
  3. HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species NO Synthase Autophagy Apoptosis
  4. Ethyl 3,4-dihydroxybenzoate (Standard)

Ethyl 3,4-dihydroxybenzoate (Standard)  (Synonyms: Protocatechuic acid ethyl ester (Standard))

Cat. No.: HY-W016409R Purity: ≥98%
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Ethyl 3,4-dihydroxybenzoate (Standard) (Protocatechuic acid ethyl ester (Standard)) is the analytical standard of Ethyl 3,4-dihydroxybenzoate (HY-W016409). This product is intended for research and analytical applications. Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema.

For research use only. We do not sell to patients.

Ethyl 3,4-dihydroxybenzoate (Standard) Chemical Structure

Ethyl 3,4-dihydroxybenzoate (Standard) Chemical Structure

CAS No. : 3943-89-3

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Description

Ethyl 3,4-dihydroxybenzoate (Standard) (Protocatechuic acid ethyl ester (Standard)) is the analytical standard of Ethyl 3,4-dihydroxybenzoate (HY-W016409). This product is intended for research and analytical applications. Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema.

Molecular Weight

182.18

Formula

C9H10O4
CAS No.
SMILES

O=C(OCC)C1=CC=C(O)C(O)=C1
Structure Classification
Initial Source
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Ethyl 3,4-dihydroxybenzoate (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Ethyl 3,4-dihydroxybenzoate (Standard)3943-89-3Protocatechuic acid ethyl ester (Standard)HIF/HIF Prolyl-HydroxylaseReactive Oxygen SpeciesNO SynthaseAutophagyApoptosisHypoxia-inducible factorsHIFsHIF-PHNitric oxide synthasesNOSprolyl-hydroxylaseantioxidantmitochondrialROScollagenInhibitorinhibitorinhibit

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