Search Result
Results for "
carboxylic acid
" in MedChemExpress (MCE) Product Catalog:
67
Biochemical Assay Reagents
40
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D1319A
-
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Cy5 acid bromide
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Fluorescent Dye
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Others
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Cyanine5 carboxylic acid (bromide) is a fluorescent dye containing a non-activated carboxylic acid (Ex=646 nm, Em=662 nm). Cyanine5 carboxylic acid chloride is an non-reactive dye that can be used in control samples .
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-
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- HY-D1823
-
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VF 647A carboxylic acid（free acid）
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Fluorescent Dye
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Others
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Vari Fluor 647A Carboxylic acid (VF 647A Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
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-
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- HY-D1830
-
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VF 680 carboxylic acid（free acid）
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Fluorescent Dye
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Others
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Vari Fluor 680 Carboxylic acid (VF 680 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
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- HY-D1825
-
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VF 532 carboxylic acid（free acid）
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Fluorescent Dye
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Others
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Vari Fluor 532 Carboxylic acid (VF 532 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
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-
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- HY-D1824
-
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VF 488 carboxylic acid（free acid）
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Fluorescent Dye
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Others
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Vari Fluor 488 Carboxylic acid (VF 488 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
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-
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- HY-D1826
-
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VF 594 carboxylic acid（free acid）
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Fluorescent Dye
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Others
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Vari Fluor 594 Carboxylic acid (VF 594 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
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- HY-D1821
-
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VF 750 carboxylic acid（free acid）
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Fluorescent Dye
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Others
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Vari Fluor 750 Carboxylic acid (VF 750 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
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-
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- HY-D1828
-
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VF 640 carboxylic acid（free acid）
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Fluorescent Dye
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Others
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Vari Fluor 640 Carboxylic acid (VF 640 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
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- HY-D1829
-
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VF 568 carboxylic acid（free acid）
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Fluorescent Dye
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Others
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Vari Fluor 568 Carboxylic acid (VF 568 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
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-
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- HY-D1827
-
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VF 660 carboxylic acid（free acid）
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Fluorescent Dye
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Others
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Vari Fluor 660 Carboxylic acid (VF 660 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
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-
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- HY-D1822
-
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VF 555 carboxylic acid（free acid）
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Fluorescent Dye
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Others
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Vari Fluor 555 Carboxylic acid (VF 555 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
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-
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- HY-107443A
-
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(R)-Molibresib carboxylic acid; (R)-GSK525762A carboxylic acid; (R)-PROTAC BRD4-binding moiety 2
|
Ligands for Target Protein for PROTAC
Epigenetic Reader Domain
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Cancer
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(R)-I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid (HY-107443). I-BET762 carboxylic acid is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 value of 5.1 .
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- HY-D2176
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Fluorescent Dye
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Others
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AF 555 carboxylic acid is a derivative of the orange fluorescent dye AF 555. AF 555 carboxylic acid is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling. AF 555 exhibits average excitation wavelengths under green laser and red laser of 510 nm and 610 nm, respectively .
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- HY-P10563
-
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BHV-1100
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CD38
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Cancer
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Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .
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- HY-D1650
-
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Fluorescent Dye
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Others
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BDP 630/650 carboxylic acid is a bright far-red fluorophore based on a borondipyrromethene scaffold. BDP 630/650 carboxylic acid is a BDP linker containing carboxylic acid. BDP 630/650 carboxylic acid can react with primary amine groups to form a stable amide bond. (λex=630 nm, λem=650 nm) .
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- HY-W027968
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2-Oxochromene-3-carboxylic acid
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Fluorescent Dye
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Cancer
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Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line .
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- HY-W073501A
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-
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- HY-W775306
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-
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- HY-70002B
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MDV3100 carboxylic acid
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Drug Metabolite
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Cancer
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Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist .
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- HY-133022
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(E)-2-Undecenoic acid; (E)-Undec-2-enoic acid
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Drug Isomer
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Metabolic Disease
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trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O .
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- HY-W002328
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Biochemical Assay Reagents
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Others
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Pyrazole-3-carboxylic acid is an alternative anchoring group to carboxylic acid in phthalocyanine dyes. Pyrazole-3-carboxylic acid shows flexible coordination modes when coordinates with metal ions. Pyrazole-3-carboxylic acid can chelate to metal ions and form very stable complexes through its N and O atoms. Pyrazole-3-carboxylic acid can be used to synthesize derivatives that possess antibacterial, anti-inflammatory, ulcerogenic liability and antiproliferative activities .
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- HY-40161
-
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Endogenous Metabolite
Bacterial
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Metabolic Disease
Cancer
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Indole-3-carboxylic acid is an orally active urinary indolic tryptophan metabolite. Indole-3-carboxylic acid is a mediator of priming against Plectosphaerella cucumerina. Indole-3-carboxylic acid enhances the anti-colorectal cancer potency of Doxorubicin (HY-15142A) by inducing cell senescence. Indole-3-carboxylic acid can be used in liver disease research .
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- HY-W002011
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Glycosidase
Amylases
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Metabolic Disease
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Quinoline-2-carboxylic acid exhibits antidiabetic activity. Quinoline-2-carboxylic acid can be used as drug intermediate for synthesis of various active compounds .
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- HY-W001963R
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Reference Standards
Endogenous Metabolite
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Others
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Pyrrole-2-carboxylic acid (Standard) is the analytical standard of Pyrrole-2-carboxylic acid. This product is intended for research and analytical applications. Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov. Pyrrole-2-carboxylic acid is a biological form of pyrrole that is often encountered in natural compounds. Pyrrole-2-carboxylic acid serves as a precursor for various pyrrole derivatives like clorobiocin, coumermycin A1, pyoluteorin, leupyrrins, and undecylprodigiosin in biosynthetic processes .
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- HY-I0096
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Endogenous Metabolite
iGluR
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Neurological Disease
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Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current .
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- HY-79494
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NSC 27785; Formylformic acid; Oxalaldehydic acid
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Endogenous Metabolite
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Neurological Disease
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Glyoxalic acid (NSC 27785) (50% in water) is an organic compound that is both an aldehyde and a carboxylic acid. Glyoxalic acid (50% in water) induces fluorescence. Glyoxalic acid (50% in water) is used to study neurons .
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- HY-33037
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Fungal
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Infection
Inflammation/Immunology
Cancer
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Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation .
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- HY-W001963
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Endogenous Metabolite
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Others
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Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov. Pyrrole-2-carboxylic acid is a biological form of pyrrole that is often encountered in natural compounds. Pyrrole-2-carboxylic acid serves as a precursor for various pyrrole derivatives like clorobiocin, coumermycin A1, pyoluteorin, leupyrrins, and undecylprodigiosin in biosynthetic processes .
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- HY-W004615R
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Biochemical Assay Reagents
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Others
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Thiophene-3-carboxylic acid (Standard) is the analytical standard of Thiophene-3-carboxylic acid. This product is intended for research and analytical applications. Thiophene-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W488088
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- HY-40161R
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Endogenous Metabolite
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Metabolic Disease
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Indole-3-carboxylic acid (Standard) is the analytical standard of Indole-3-carboxylic acid. This product is intended for research and analytical applications. Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .
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- HY-W050044
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- HY-33037R
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Fungal
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Infection
Inflammation/Immunology
Cancer
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Phenazine-1-carboxylic acid (Standard) is the analytical standard of Phenazine-1-carboxylic acid. This product is intended for research and analytical applications. Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation[1][2][3][4].
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- HY-W037823
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Biochemical Assay Reagents
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Others
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Pterin-6-carboxylic acid serves as a precursor for the formation of folate, which plays a critical role in cell growth, development, and repair. Pterine-6-carboxylic acid has been studied for its potential as a fluorescent dye .
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- HY-W585407
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Fluorescent Dye
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Others
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BDP TMR carboxylic acid is a BDP TMR labeled carboxylic acid. BDP TMR carboxylic acid has the fluorophore BDP and can be used for oligonucleotide labeling and amino acid sequencing .
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- HY-Y0530
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ADC Linker
PROTAC Linkers
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Cancer
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Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
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- HY-75308
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Others
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Cancer
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Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent .
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- HY-34887
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Drug Derivative
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Others
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Acridone-4-carboxylic acid (ACA) (Compound 2c) is a heme-interacting acridone derivatives that prevents free heme-mediated protein oxidation and degradation. Acridone-4-carboxylic acid inhibits protein carbonyl formation with an IC50 of 43 μM .
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- HY-70002BS
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- HY-W039519
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Fluorescent Dye
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Cancer
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7-Methoxycoumarin-3-carboxylic acid is a fluorescent dye with an excitation peak at 355 nm and an emission peak at 405 nm. 7-Methoxycoumarin-3-carboxylic acid can be used to label peptide .
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- HY-30004
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Endogenous Metabolite
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Cardiovascular Disease
Metabolic Disease
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1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity. .
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- HY-N2321
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- HY-132266
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Fluorescent Dye
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Others
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BDP TR carboxylic acid is a carboxylic acid derivative of BDP TR. BDP TR is a BODIPY fluorescent probe .
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- HY-W017755
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ADC Linker
PROTAC Linkers
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Cancer
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(R)-Azetidine-2-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker that can be
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- HY-133022R
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(E)-2-Undecenoic acid (Standard); (E)-Undec-2-enoic acid (Standard)
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Drug Isomer
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Metabolic Disease
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trans-2-Undecenoic acid (Standard) is the analytical standard of trans-2-Undecenoic acid. This product is intended for research and analytical applications. trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O[1].
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- HY-107443
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Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2
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Ligands for Target Protein for PROTAC
Epigenetic Reader Domain
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Cancer
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I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1 .
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- HY-D1338
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Cyanine 3.5 carboxylic acid chloride; Lumiprobe Cy 3.5 carboxylic acid chloride
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Fluorescent Dye
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Others
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Cyanine3.5 carboxylic acid chloride is an anthocyanin dye. Cyanine3.5 carboxylic acid chloride is Cyanine3.5 free unactivated monofunctional carboxylic acid and can be used as a reference or control for non-reactive dye. Cyanine3.5 also is an analog of Cy3.5 fluorophore .
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- HY-W002011S
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Isotope-Labeled Compounds
Glycosidase
Amylases
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Metabolic Disease
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Quinoline-2-carboxylic acid-d6 is the deuterium labeled Quinoline-2-carboxylic acid (HY-W002011). Quinoline-2-carboxylic acid exhibits antidiabetic activity. Quinoline-2-carboxylic acid can be used as drug intermediate for synthesis of various active compounds .
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- HY-I0096S
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- HY-135500
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Endothelin Receptor
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Endocrinology
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ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist .
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- HY-W011277
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ADC Linker
PROTAC Linkers
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Cancer
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Fmoc-azetidine-3-carboxylic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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- HY-145991R
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Drug Metabolite
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Infection
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Ribavirin carboxylic acid (Standard) is the analytical standard of Ribavirin carboxylic acid. This product is intended for research and analytical applications. Ribavirin carboxylic acid (TR-COOH) is a metabolite of Ribavirin (HY-B0434), Ribavirin has strong antiviral activity .
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- HY-60256
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- HY-N6877
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Others
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Cancer
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Purpurogallin carboxylic acid, isolated from Macleaya microcarpa (Maxim.) Fedde, is an oxidation product of gallic acid in fermented tea. Purpurogallin carboxylic acid has anti-cancer activity .
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- HY-W016473S
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- HY-12863B
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- HY-30004R
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Endogenous Metabolite
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Cardiovascular Disease
Metabolic Disease
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1-Aminocyclopropane-1-carboxylic acid (Standard) is the analytical standard of 1-Aminocyclopropane-1-carboxylic acid. This product is intended for research and analytical applications. 1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity. .
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- HY-12765R
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Drug Metabolite
Angiotensin Receptor
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Cardiovascular Disease
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Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure [4].
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- HY-W017763S
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- HY-W031757
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Others
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Inflammation/Immunology
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Anthraquinone-2-carboxylic acid is a major anthraquinone isolated from Brazilian taheebo, with anti-inflammatory activity and antinociceptive .
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- HY-D1374
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Fluorescent Dye
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Sulfo-Cy5 carboxylic acid potassium is a water-soluble, inactive Cy5 carboxylic acid.
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- HY-W002518
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Biochemical Assay Reagents
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Others
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Indazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002066
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Biochemical Assay Reagents
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Others
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Pyridazine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W004855
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Biochemical Assay Reagents
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Others
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Quinoline-6-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002404
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Biochemical Assay Reagents
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Others
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Pyrimidine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W004615
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Biochemical Assay Reagents
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Others
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Thiophene-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-144001
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Liposome
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Others
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DSPE-PEG-Carboxylic Acid is a phospholipid PEG conjugate. DSPE-PEG-Carboxylic Acid can be widely used in the delivery of targeted agents and genes .
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- HY-29268
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Bacterial
Indoleamine 2,3-Dioxygenase (IDO)
NF-κB
Phosphodiesterase (PDE)
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Infection
Inflammation/Immunology
Cancer
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β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL) .
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- HY-D0115
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DNA Stain
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Others
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7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. 7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is a blue fluorescent dye for labeling proteins and nucleic acids .
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- HY-W002304R
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Endogenous Metabolite
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Metabolic Disease
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(R)-5-Oxopyrrolidine-2-carboxylic acid (Standard) is the analytical standard of (R)-5-Oxopyrrolidine-2-carboxylic acid. This product is intended for research and analytical applications. (R)-5-Oxopyrrolidine-2-carboxylic acid is an endogenous metabolite.
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- HY-W007371
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Biochemical Assay Reagents
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Others
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Quinoline-8-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-40161S
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- HY-30004S
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- HY-76210
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- HY-W269179
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Fluorescent Dye
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Cancer
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4-Bromomethyl-6,7-dimethoxycoumarin is a fluorescent label for carboxylic acids in chromatographic detection .
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- HY-W022164
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- HY-W806655
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Fluorescent Dye
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Others
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Cy3.5 carboxylic acid is a fluorophore featuring a carboxylic acid. The carboxylic acid is readily attacked by amines to form a stable amide bond. Cy3.5 is a cyanine dye with excitation and emission maxima at 576 nm and 603 nm respectively.
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- HY-D1656
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Fluorescent Dye
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Others
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BDP 581/591 carboxylic acid is a fluorescent dye (Ex=585 nm, Em=594 nm). BDP 581/591 carboxylic acid has a free carboxylic acid group, which can be catalyzed by a catalyst (such as EDC or HATU) to react with primary amines to form stable amide bonds. BDP 581/591 carboxylic acid is highly photostable and can be used for ROS detection.
|
-
- HY-W042027
-
|
8-Isoquinoline-methaneaminedihydrochloride
|
Bacterial
Biochemical Assay Reagents
|
Infection
Inflammation/Immunology
Cancer
|
|
Isothiazole-5-carboxylic acid (8-Isoquinoline-methaneaminedihydrochloride) is an organic compound with antibacterial, anticancer and anti-inflammatory properties. Isothiazole-5-carboxylic acid can be used to develop novel compounds to combat various diseases. Isothiazole-5-carboxylic acid exhibits a wide range of potential pharmacological activities and helps improve existing inhibitory schemes.
|
-
- HY-D1623
-
|
|
Fluorescent Dye
|
Others
|
|
Cyanine3 carboxylic acid chloride is a non-toxic red fluorescent dye with good solubility in organic solvents. Cyanine3 carboxylic acid chloride can be used as a non-reactive fluorophore for experimental control and calibration. Cyanine3 carboxylic acid chloride can also be synthesized with targeted agents as fluorescent probes for rapid detection of agent reactions .
|
-
- HY-66047
-
-
- HY-124356
-
|
|
Histamine Receptor
|
Inflammation/Immunology
|
|
Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01% .
|
-
- HY-W591818
-
|
|
Drug Derivative
|
Cancer
|
|
Sunitinib carboxylic acid is a carboxylic acid metabolite of Sunitinib (HY-10255A). Sunitinib is a multi-target tyrosine kinase inhibitor, mainly used to inhibit malignant tumors such as gastrointestinal stromal tumors, renal cell carcinoma, and pancreatic neuroendocrine tumors .
|
-
- HY-W098280
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Phenylglycine methyl ester is a chiral anisotropic reagent. Phenylglycine methyl ester can be used for absolute configuration determination of various chiral carboxylic acids .
|
-
- HY-W002304
-
-
- HY-131314S
-
-
- HY-157071S
-
-
- HY-W740380
-
|
|
Drug Metabolite
|
Others
|
|
21-Carboxylic acid triamcinolone acetonide is a metabolite produced in the body after oral administration of [14C]-triamcinolone acetonide .
|
-
- HY-W061650
-
-
- HY-76962
-
-
- HY-W002255
-
-
- HY-40141
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]
|
-
- HY-W004868
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]
|
-
- HY-D1885
-
|
|
Fluorescent Dye
|
Others
|
|
Vari Fluor 647 Carboxylic acid free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivative is an inactive labeled fluorescent dye, which can be used to label proteins, antibodies, polysaccharides. The use of Vari Fluor carboxylic acid derivatives requires carboxylic acid activation.
|
-
- HY-W585384
-
|
|
Fluorescent Dye
|
Others
|
|
BDP 558/568 carboxylic acid is a BDP linker containing a carboxylic acid. The BDP 558/568 has similar excitation and emission wavelengths to Cy3. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-76835
-
|
|
Factor Xa
|
Others
|
|
5-Chlorothiophene-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-33287
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Bromothiazole-5-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W011560
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3-Methylflavone-8-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-32739
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-Methylpyrazine-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N1635
-
|
|
Others
|
Others
|
|
1-Methoxyindole-3-carboxylic acid (compound 5) is synthetic from a phytoalexin nucleophilic substitution reaction selectively at the 2-position .
|
-
- HY-114799
-
|
4-Methyl-2-pyridin-4-ylthiazole-5-carboxylic acid
|
Drug Intermediate
|
Others
|
|
2-(4-Pyridyl)-4-methyl-thiazole-5-carboxylic acid (4-Methyl-2-pyridin-4-ylthiazole-5-carboxylic acid) is a synthetic intermediate useful for pharmaceutical synthesis.
|
-
- HY-12765S1
-
|
|
Isotope-Labeled Compounds
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .
|
-
- HY-I0177
-
|
|
Drug Metabolite
|
Others
|
|
Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor) .
|
-
- HY-124356AS
-
|
|
Isotope-Labeled Compounds
Histamine Receptor
|
Inflammation/Immunology
|
|
Alcaftadine carboxylic acid-d3 (sodium) is deuterium labeled Alcaftadine carboxylic acid. Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01% .
|
-
- HY-W007695
-
|
4-Imidazolecarboxylic acid
|
Biochemical Assay Reagents
|
Others
|
|
1H-Imidazole-4-carboxylic acid is an organic compound containing an imidazole ring and a carboxyl group. 1H-Imidazole-4-carboxylic acid stabilizes specific forms of metal ions through coordination, thus influencing the progress of chemical reactions. 1H-Imidazole-4-carboxylic acid plays an important role in the hydrolysis of phosphate esters catalyzed by lanthanide metals. 1H-Imidazole-4-carboxylic acid can be used to modify dendrimers, changing the surface properties and catalytic performance of materials .
|
-
- HY-Y0236
-
|
Naphthalene-1-carboxylic acid
|
Biochemical Assay Reagents
|
Others
|
|
Naphthalene-1-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-101329R
-
|
9-Anthracenecarboxylic acid (Standard)
|
Reference Standards
Chloride Channel
|
Others
|
|
Anthracene-9-carboxylic acid (Standard) is the analytical standard of Anthracene-9-carboxylic acid. This product is intended for research and analytical applications. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells .
|
-
- HY-P2947
-
|
Aldehyde dehydrogenase (NAD(P))
|
Aldehyde Dehydrogenase (ALDH)
|
Others
Cancer
|
|
ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress .
|
-
- HY-D0035
-
|
|
Fluorescent Dye
|
Others
|
|
MPAC-Br is a highly sensitive fluorescent derivatization reagent for carboxylic acids in HPLC .
|
-
- HY-W011560S
-
-
- HY-D1169
-
|
|
Fluorescent Dye
|
Others
|
|
BDP R6G carboxylic acid is a borondipyrromethene dye (Excitation: 530 nM; Emission: 548 nM). BDP R6G carboxylic acid terminal carboxylic acid can react with primary amine groups in the presence of activators to form a stable amide bond, for subsequent labeling reactions like Steglich esterification .
|
-
- HY-W015420
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1H-Indole-6-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002064
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1H-Benzimidazole-6-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-D1305
-
|
|
Fluorescent Dye
|
Others
|
|
ATTO 488 carboxylic acid is a new fluorescent label based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 carboxylic acid is a carboxylic acid derivative of ATTO 488, which can be used to label proteins or antibodies.
|
-
- HY-D2162
-
|
|
Fluorescent Dye
|
Others
|
|
AF 594 carboxylic acid is a carboxyl derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (Ex=594 nm, Em=615 nm). AF 594 carboxylic acid can form stable covalent bonds through the reaction of carboxylic acid groups with molecules with amino groups .
|
-
- HY-134234
-
|
|
COX
|
Others
|
|
Celecoxib carboxylic acid is a metabolite of celecoxib (HY-14398). Celecoxib is a selective COX-2 inhibitor with an IC50 of 40 nM .
|
-
- HY-145991
-
|
|
Drug Metabolite
|
Infection
|
|
Ribavirin carboxylic acid (TR-COOH) is a metabolite of Ribavirin (HY-B0434), Ribavirin has strong antiviral activity .
|
-
- HY-78695
-
|
|
Epigenetic Reader Domain
PD-1/PD-L1
|
Cancer
|
|
JQ-1 carboxylic acid, a (+)-JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4.
|
-
- HY-W007927R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1-Methyl-1H-indazole-3-carboxylic acid (Standard) is the analytical standard of 1-Methyl-1H-indazole-3-carboxylic acid. This product is intended for research and analytical applications. 1-Methyl-1H-indazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W140351
-
-
- HY-D2154
-
|
|
Fluorescent Dye
|
Others
|
|
AF 430 carboxylic acid is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 carboxylic acid can form covalent bonds through a condensation reaction between carboxylic acid groups and molecules containing amino groups. To achieve specific coupling of dye labels and biomolecules .
|
-
- HY-W002623
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-D2250
-
|
|
Fluorescent Dye
|
Others
|
|
Disulfo-ICG carboxylic acid is a derivative of ICG dye. ICG (Indocyanine Green) is a NIR fluorescent dye .
|
-
- HY-D1317A
-
|
|
Fluorescent Dye
|
Others
|
|
Cyanine7.5 carboxylic is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid functional groups. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Cyanine7.5 carboxylic can be covalently bound to some biological molecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
|
-
- HY-D1317
-
|
|
Fluorescent Dye
|
Others
|
|
Cyanine7.5 carboxylic acid chloride is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid functional groups. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Cyanine7.5 carboxylic acid chloride can be covalently bound to some biological molecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
|
-
- HY-W354369
-
-
- HY-107870
-
-
- HY-126666
-
|
|
ADC Cytotoxin
|
Inflammation/Immunology
Cancer
|
|
PNU-159682 carboxylic acid (compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response .
|
-
- HY-W007586
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(S)-1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-D1881
-
-
- HY-D2160
-
|
|
Fluorescent Dye
|
Others
|
|
AF 647 carboxylic acid is a derivative of the far-infrared dye AF 647. AF 647 is often used as a replacement for Cy5 dye, with an excitation wavelength (λex) of 635 nm (conventional fluorescence detection)/620 nm (instantaneous detection). The maximum excitation wavelength is 647 nm and the maximum emission wavelength is 671 nm. AF 647 carboxylic acid has a carboxylic acid group and can be coupled to biomolecules with amino groups to achieve dye labeling .
|
-
- HY-12765
-
|
E-3174; EXP-3174
|
Drug Metabolite
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .
|
-
- HY-W028714
-
|
|
Drug Intermediate
|
Others
|
|
2,3-Diphenylquinoxaline-6-carboxylic acid is used for end-capping in the synthesis of AB2 monomers, which facilitates the synthesis and chain-end modification of hyperbranched polymers containing alternating quinoxaline and benzoxazole repeating units .
|
-
- HY-W000793S
-
-
- HY-W051624S
-
-
- HY-N9192
-
|
|
Others
|
Others
|
|
2,2-Dimethyl-8-prenylchromene 6-carboxylic acid (compound 2) is a natural product that can be found in Piper aduncum .
|
-
- HY-40226
-
|
|
Drug Intermediate
|
Others
|
|
4-Amino-1-Boc-piperidine-4-carboxylic acid serves as a key intermediate for constructing various bioactive compounds .
|
-
- HY-131314
-
|
|
Drug Metabolite
|
Others
|
|
Ibuprofen carboxylic acid is the metabolite of Ibuprofen (HY-78131), that has high concentrations in wastewater and water environments, and disappears fast during biodegradation, compared to the other ibuprofen metabolite .
|
-
- HY-20302R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(2S,3AS,7aS)-Octahydroindole-2-carboxylic acid (Standard) is the analytical standard of (2S,3AS,7aS)-Octahydroindole-2-carboxylic acid. This product is intended for research and analytical applications. (2S,3AS,7aS)-Octahydroindole-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N1905
-
|
|
Others
|
Others
|
|
4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline .
|
-
- HY-W654362
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
(R)-2-Thioxothiazolidine-4-carboxylic acid- 13C3 is the 13C-labeled (R)-2-Thioxothiazolidine-4-carboxylic acid. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-W051093
-
-
- HY-148377
-
|
|
Drug Metabolite
|
Cancer
|
|
Abiraterone sulfate N-oxide is a carboxylic acid. Abiraterone sulfate N-oxide also is a major metabolite of Abiraterone (HY-70013). Abiraterone sulfate N-oxide can be used for the research of prostate cancer .
|
-
- HY-W077074S
-
-
- HY-W403633
-
|
|
Bacterial
|
Infection
|
|
Hexahydrohippuric acid is a metabolite of Shikimate acid in both liver and kidney, under microbial metabolism effect. Hexahydrohippuric acid is made of cyclohexane carboxylic acid and glycinamide, and shows antibacterial activity .
|
-
- HY-W012428
-
|
|
Drug Intermediate
|
Others
|
|
2-(3-Pyridyl)-4-methyl-thiazole-5-carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis.
|
-
- HY-W044620
-
-
- HY-114756
-
|
|
Drug Intermediate
|
Others
|
|
2-(2-Pyridyl)-4-methyl-thiazole-5-carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis.
|
-
- HY-N7692
-
|
|
Others
|
Others
|
|
Polyporusterone A is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone A has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis) .
|
-
- HY-137919
-
-
- HY-D2493
-
|
Cy7 COOH
|
Fluorescent Dye
|
Others
|
|
Cyanine7 carboxylic acid (Cy7 COOH) is a derivative of Cy7 (HY-D0825) dye. Cyanine7 carboxylic acid contains carboxyl groups, which can condense ammonia to form covalent bonds .
|
-
- HY-D0068
-
|
7-Diethylaminocoumarin-3-carboxylic acid, SE
|
Fluorescent Dye
|
Others
|
|
DEAC, SE (7-Diethylaminocoumarin-3-carboxylic acid, SE) is an excellent blue fluorescent building block for labeling amine-containing biomolecules.
|
-
- HY-W725295
-
-
- HY-D2172
-
|
|
Fluorescent Dye
|
Others
|
|
AF488 carboxylic acid is a non-reactive AF 488 form. AF488 exhibits the λem and λex wavelength of 520 nm and 470 nm, respectively .
|
-
- HY-141892A
-
|
DSPE PEG(2000) carboxylic acid sodium
|
Liposome
|
Others
|
|
DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid that can be used in the preparation of drug delivery nanoparticles .
|
-
- HY-101329
-
|
9-Anthracenecarboxylic acid
|
Chloride Channel
|
Others
|
|
Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca 2+-activated Cl - currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells .
|
-
- HY-D1366A
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-Cyanine5.5 carboxylic acid potassium is a fluorescent dye with excitation/emission wavelengths at 673/707 nm. The introduction of the sulfite group enhances the hydrophilic properties of the compound. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC and HATU, to form stable amide bonds.
|
-
- HY-59302
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Indole-5-carboxylic acid, 98% is an oxytocin that interacts with serotonin receptors and gamma-aminobutyric acid (GABA) receptors. It has also been reported to interact with various enzymes such as cyclooxygenase-2 (COX-2) and 5-hydroxytryptamine (5-HT) receptors.
|
-
- HY-D1083
-
|
|
Fluorescent Dye
|
Others
|
|
7-Methoxycoumarin-3-carboxylic acid, SE can be used for the synthesis of hydrophilic dye compound 12. Compound 12 shows a homogeneous distribution inside the cell and represents a suitable probe for viscosity measurements in the cytoplasm .
|
-
- HY-34603
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1-Methyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007927
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1-Methyl-1H-indazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007593
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-Bromo-1H-indole-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-40014
-
|
1-Boc-Piperidine-3-carboxylic acid
|
Biochemical Assay Reagents
|
Others
|
|
1-Boc-piperidine-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-66035
-
|
4-(Trifluoromethyl)pyridine-3-carboxylic acid
|
Parasite
|
Infection
|
|
4-(Trifluoromethyl)nicotinic acid (4-(Trifluoromethyl)pyridine-3-carboxylic acid) is a metabolite of the pyridinecarboxamide insecticide Flonicamid (HY-119649) .
|
-
- HY-D2749
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-Bis-(N,N'-carboxylic acid)-Cy5 is a free unactivated carboxylic acid. Its absorbance and emission spectra are identical with Cy5 fluorophore.
|
-
- HY-135895
-
-
- HY-N7693
-
|
|
Others
|
Others
|
|
Polyporusterone B is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone B has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis) .
|
-
- HY-D1881A
-
-
- HY-141749B
-
|
CLPM hydrochloride; SR 26334 hydrochloride
|
Drug Metabolite
|
Cardiovascular Disease
|
|
Clopidogrel carboxylic acid (CLPM) hydrochloride is an inactive metabolite of the widely used antiplatelet medication clopidogrel, which serves as a reference standard for quantitative analysis of clopidogrel metabolism. Clopidogrel carboxylic acid hydrochloride has been shown to represent approximately 85% of circulating clopidogrel, hydrolyzed from the active form by esterases. Clopidogrel carboxylic acid hydrochloride plays a crucial role in assessing the pharmacokinetics and bioavailability of clopidogrel in various clinical and research settings.
|
-
- HY-33169
-
-
- HY-34781
-
-
- HY-Y0549
-
|
Diphenylmethane-α-carboxylic acid
|
Biochemical Assay Reagents
|
Others
|
|
Diphenylacetic acid (Diphenylmethane-α-carboxylic Acid) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-121123
-
|
2-Aminoadamantane-2-carboxylic acid
|
Aminopeptidase
|
Cancer
|
|
Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (Ki is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC50 of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S0.5 of 10.5 .
|
-
- HY-N4226R
-
|
|
AP-1
|
Inflammation/Immunology
Cancer
|
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (Standard) is the analytical standard of 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid. This product is intended for research and analytical applications. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function[1].
|
-
- HY-75087
-
|
(+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms .
|
-
- HY-W002155
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Tetrahydropyran-4-yl-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-101329S
-
|
9-Anthracenecarboxylic acid-d9
|
Chloride Channel
|
Others
|
|
Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid . Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells .
|
-
- HY-W004978
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1,5-Dimethyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W127704
-
|
|
Biochemical Assay Reagents
|
Others
|
|
IR 754 Carboxylic Acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-D1866
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-Cy7.5 carboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate ion (sulfonate) functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 carboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
|
-
- HY-168912
-
|
|
PROTAC Linkers
|
Cancer
|
|
3,9-Diazaspiro[5.5]undecane-3-carboxylic acid is the linker that can be used for synthesis of PROTAC c-Met degrader-3 (HY-168910) .
|
-
![3,9-Diazaspiro[5.5]undecane-3-carboxylic acid](//file.medchemexpress.eu/product_pic/hy-168912.gif)
- HY-B1169
-
|
1,3-Thiazolidine-4-carboxylic acid
|
Amino Acid Derivatives
|
Cardiovascular Disease
Cancer
|
|
Timonacic (1,3-Thiazolidine-4-carboxylic acid) is an orally active thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects. Timonacic has a LD50 of 400 mg/kg for mice. Timonacic can be used in the research of liver diseases, gastrointestinal diseases, and cancer .
|
-
- HY-100160
-
|
2-Octadecyl-1H-indole-5-carboxylic acid
|
Others
|
Cardiovascular Disease
|
|
RP 54275 (2-Octadecyl-1H-indole-5-carboxylic acid) is a novel hypocholesterolaemic agent.
|
-
- HY-W088089
-
|
|
Fluorescent Dye
|
Cancer
|
|
ICG-carboxylic acid is near-infrared (NIR) fluorescent probe. ICG is a fluorescent dye used in medical diagnostics. ICG has absorption peaking at 800 nm and can absorb the near IR laser energy and release heat in the dyed tissue (Ex/Em = 785/810 nm) .
|
-
- HY-75087R
-
|
(+)-(R)-Proline (Standard); (R)-(+)-Proline (Standard); (R)-2-Carboxypyrrolidine (Standard); (R)-Proline (Standard)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-pyrrolidine-2-carboxylic acid (Standard) is the analytical standard of (R)-pyrrolidine-2-carboxylic acid. This product is intended for research and analytical applications. (R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms[1].
|
-
- HY-20302
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(2S,3AS,7aS)-Octahydroindole-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W741575
-
-
- HY-17512S1
-
-
- HY-W168915S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid-d3 is deuterium labeled 1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid.
|
-
- HY-D1337
-
|
|
Fluorescent Dye
|
|
|
Cyanine7 carboxylic acid chloride belongs to the cyanine dye series and is a common fluorescent marker for biomolecules that can interact with biomolecules. Cyanine dyes may also bind to double-helical DNA through intercalation and exhibit enhanced fluorescence upon binding.
|
-
- HY-D1326
-
|
|
Fluorescent Dye
|
Others
|
|
Cyanine3 carboxylic acid belongs to the cyanine dye series and is a common fluorescent marker for biomolecules that can interact with biomolecules. Cyanine dyes may also bind to double-helical DNA through intercalation and exhibit enhanced fluorescence upon binding.
|
-
- HY-Y1754
-
|
TOAC
|
Biochemical Assay Reagents
|
|
|
2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid (TOAC) is a compound with the ability to probe conformational changes, folding processes and interactions of peptides and proteins. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid is often used in relevant biological research to gain a deeper understanding of the behavior and function of biomacromolecules. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid plays an important role in analyzing the interactions and dynamic responses of biological systems.
|
-
- HY-N4226
-
|
|
AP-1
|
Inflammation/Immunology
Cancer
|
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function .
|
-
- HY-D1367
-
|
|
Fluorescent Dye
|
|
|
Sulfo-Cyanine7 carboxylic acid is a highly hydrophilic and water-soluble near-infrared dye. It improves quantum yield in the near-infrared range and has a very high molar extinction coefficient.
|
-
- HY-22365
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-D1853
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-Cy5 carboxylic acid is a Cy5 derivative that can be used for chemical synthesis. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) .
|
-
- HY-W998662
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin 343 X carboxylic acid is a blue emitting fluorophore used as a laser dye. The fluorophore can serve as a FRET donor for FAM (fluorescein).
|
-
- HY-W018326
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
Temozolomide acid is a carboxylic acid derivative of Temozolomide (HY-17364) with anticancer activity. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide acid is promising for research of glioblastoma and brain cancer .
|
-
- HY-W158239
-
-
![4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid](//file.medchemexpress.eu/product_pic/hy-w158239.gif)
- HY-134235
-
-
- HY-W722107
-
|
1,3-Thiazolidine-4-carboxylic acid-d4
|
Isotope-Labeled Compounds
Amino Acid Derivatives
|
Cardiovascular Disease
Cancer
|
|
Timonacic-d4 (1,3-Thiazolidine-4-carboxylic acid-d4) is deuterium labeled Timonacic. Timonacic (1,3-Thiazolidine-4-carboxylic acid) is a thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects, and it can be used to study acute illnesses and liver diseases, by inducing reversal, it is also used in research on certain cancer cases .
|
-
- HY-169499
-
|
|
Acyltransferase
|
Metabolic Disease
|
|
(R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid is an intermediate in the synthesis of the diacylglycerol acyltransferase 2 (DGAT-2) inhibitor Ervogastat.
|
-
- HY-W018158
-
|
5,6-Dihydroxyindole-2-carboxylic acid
|
Endogenous Metabolite
GPR35
Arrestin
|
Others
|
|
DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of true black pigment, and it’s also a moderately potent GPR35 agonist. DHICA shows an ability to stimulate β-arrestin translocation signaling with an EC50 value of 23.2 μM in the U2OS cell line. DHICA plays a significant role in promoting and protecting against DNA damage .
|
-
- HY-154085
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
(2’,3’,5’-Tri-O-acetyl)uridine 5-carboxylic acid is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-141749A
-
-
- HY-124534
-
-
- HY-W061761
-
|
|
Drug Intermediate
|
Others
|
|
(1R,3S)-3-Aminocyclopentane carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis.
|
-
- HY-D2169
-
|
|
Fluorescent Dye
|
Others
|
|
AF 568 carboxylic acid is the non-reactive form of the orange fluorescent dye AF 568. AF 568 has an absorption wavelength of 590-720 nm (FRET) and an emission wavelength of 515-720 nm. AF 568 alkyne forms stable covalent bonds by reacting carboxylic acid groups with molecules bearing amino groups. Copper-catalyzed azide-alkyne cycloaddition (CuAAc) can occur with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups .
|
-
- HY-D1853A
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-Cy5 carboxylic acid TEA is a Cy5 derivative that can be used for chemical synthesis. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) .
|
-
- HY-G0024A
-
|
Vildagliptin carboxy acid metabolite TFA
|
Cytochrome P450
|
Metabolic Disease
|
|
Vildagliptin carboxylic acid metabolite (M20.7) TFA is a potent P450 enzyme activity inhibitor .
|
-
- HY-W246043
-
|
Ethyl Nicotinate-d4
|
Isotope-Labeled Compounds
|
Others
|
|
3-Pyridine-2,4,5,6-d4 -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-carboxylic acid, ethyl ester .
|
-
- HY-169082
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
JQ-1 (carboxylic acid)-NH-C2-NH-COOH is a conjugate of E3 ligase ligand and linker (E3 Ligase Ligand-Linker Conjugates), which is composed of JQ-1 carboxylic acid (HY-78695) and the corresponding linker: (2-Aminoethyl)carbamic acid (HY-W398806). JQ-1 (carboxylic acid)-NH-C2-NH-COOH can be used as a Cereblon ligand to recruit CRBN protein and as a key intermediate for the synthesis of complete PROTACs molecules .
|
-
- HY-141749AS
-
|
CLPM-d4; SR 26334-d4
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Clopidogrel carboxylic acid-d4 is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d4 can be used to further explore the metabolic characteristics of Clopidogrel .
|
-
- HY-131669
-
|
Dasatinib carboxylic acid
|
Drug Metabolite
|
Others
Cancer
|
|
Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib (HY-10181). Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase inhibitor .
|
-
- HY-141749S
-
|
(Rac)-CLPM-d4; (Rac)-SR 26334-d4
|
Isotope-Labeled Compounds
|
Others
|
|
(Rac)-Clopidogrel carboxylic acid-d4 is the deuterium labeled (Rac)-Clopidogrel carboxylic acid .
|
-
- HY-W755107
-
|
|
Drug Intermediate
|
Others
|
|
(1S,3R)-3-Hydroxycyclopentane carboxylic acid methyl ester is a synthetic intermediate useful for pharmaceutical synthesis.
|
-
- HY-W034099
-
|
|
Drug Intermediate
|
Others
|
|
(1R,3R)-3-Hydroxycyclopentane carboxylic acid methyl ester is a synthetic intermediate useful for pharmaceutical synthesis.
|
-
- HY-W394612
-
|
|
Drug Intermediate
|
Others
|
|
(1R,3S)-3-Hydroxycyclopentane carboxylic acid methyl ester is a synthetic intermediate useful for pharmaceutical synthesis.
|
-
- HY-128837
-
|
MDM2 ligand 1; E3 ligase Ligand 16
|
Ligands for E3 Ligase
|
Cancer
|
|
Nutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-75087S
-
-
- HY-W016473
-
|
|
Bacterial
|
Infection
|
|
Adamantane-carboxylic acid is a compound with inhibitory activity against microorganisms. Although its specific target has not been clearly defined, it can inhibit Gram-positive bacteria and some Gram-negative bacteria. It forms a 1-monoacylglycerol derivative through a direct reaction with glycidol, and exerts its antibacterial effect by mechanisms such as altering the permeability of the bacterial cell membrane. This compound can be used in the research of antibacterial agents in the food and cosmetic industries to reduce harmful microbial flora and extend the shelf life of products .
|
-
- HY-114553S
-
|
5F-PB-223-Carboxyindolemetabolite-d5
|
Isotope-Labeled Compounds
|
Others
|
|
1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid-d5 (5F-PB-223-Carboxyindolemetabolite-d5) is deuterium labeled 1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid .
|
-
- HY-D2755
-
|
|
Fluorescent Dye
|
Others
|
|
BP Light 650 carboxylic acid is an vibrant far-red fluorochrome with comparable or improved performance over other dyes, including BP Fluor 647 and Cy5 dye, for fluorescent applications. It is used to label antibodies and other proteins as molecular probes for cellular imaging and other fluorescence detection methods application.
|
-
- HY-W053705
-
-
- HY-D1366
-
|
|
Fluorescent Dye
|
|
|
Sulfo-Cyanine5.5 carboxylic acidCI Pigment violet 32 is a water-soluble, far-red emitting fluorophore. Due to its four sulfo groups, this dye has a negative charge at neutral pH and is very hydrophilic. As a cyanine dye, sulfo-Cyanine5.5 shows a very low dependence of fluorescence on pH and a very high extinction coefficient.
|
-
- HY-W013201
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-1-((S)-2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:1) is a proline derivative .
|
-
- HY-145243
-
|
|
Apoptosis
|
Others
|
|
PDPOB is a phenyl carboxylic acid derivative. PDPOB displays protective roles against OGD/R-evoked multiaspect neuronal deterioration in SH-SY5Y cells, as evidenced by alleviated mitochondrial dysfunction, oxidative stress, and apoptosis. PDPOB has the potential for the research of cerebral ischemia .
|
-
- HY-77584
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)non-8-enoyl)-4-hydroxypyrrolidine-2-carboxylic acid is a proline derivative .
|
-
- HY-169150A
-
-
- HY-169150
-
-
- HY-W345492
-
|
1-(Cyclohexylmethyl)-1H-indole-3-carboxylic acid Methyl Ester
|
Cannabinoid Receptor
|
Neurological Disease
|
|
Methyl-1-(cyclohexylmethyl)-1H-indole-3-carboxylate (1-(Cyclohexylmethyl)-1H-indole-3-carboxylic Acid Methyl Ester) is an analog of BB-22 that lacks the quinoline group. BB-22 is an analog of cannabinoid .
|
-
- HY-W008446
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid is a proline derivative .
|
-
- HY-128836
-
|
MDM2 ligand 2; E3 ligase Ligand 15
|
Ligands for E3 Ligase
|
Cancer
|
|
(4R,5S)-Nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-W285163S
-
|
Formyl Ciprofloxacin-d8
|
Isotope-Labeled Compounds
|
Others
|
|
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
|
-
- HY-172126
-
-
- HY-12765S
-
-
- HY-D1040
-
|
Cyanine 5.5 carboxylic acid
|
Fluorescent Dye
|
Others
|
|
Cy5.5-COOH (Cyanine 5.5 carboxylic acid) is a fluorescent dye that emits fluorescence at 710 nm upon excitation at 650 nm. Cy5.5-COOH possesses excellent spectral properties, including a narrow absorption spectrum, high sensitivity, and stability. Cy5.5-COOH can be used for bioimaging and disease diagnosis .
|
-
- HY-D1040A
-
|
Cyanine 5.5 carboxylic acid chloride
|
Fluorescent Dye
|
Others
|
|
Cy5.5-COOH (Cyanine 5.5 carboxylic acid) chloride is a fluorescent dye that emits fluorescence at 710 nm upon excitation at 650 nm. Cy5.5-COOH chloride possesses excellent spectral properties, including a narrow absorption spectrum, high sensitivity, and stability. Cy5.5-COOH chloride can be used for bioimaging and disease diagnosis .
|
-
- HY-W144430S
-
|
2-[3-(Trifluoromethyl)phenoxy]pyridine-3-carboxylic acid, 3-[(3-Carboxypyridin-2-yl)oxy]benzotrifluoride-d3
|
Isotope-Labeled Compounds
|
Others
|
|
2-[3-(Trifluoromethyl)phenoxy]nicotinic acid-d3 (2-[3-(Trifluoromethyl)phenoxy]pyridine-3-carboxylic acid, 3-[(3-Carboxypyridin-2-yl)oxy]benzotrifluoride-d3) is deuterium labeled 2-[3-(Trifluoromethyl)phenoxy]nicotinic acid .
|
-
![2-[3-(Trifluoromethyl)phenoxy]nicotinic acid-d3](//file.medchemexpress.eu/product_pic/hy-w144430s.gif)
- HY-123035
-
|
|
HSP
Akt
EGFR
|
Endocrinology
|
|
Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research .
|
-
- HY-W004812
-
|
(1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid
|
Drug Intermediate
|
Others
|
|
BOC-(1R,3S)-3-aminocyclopentane carboxylic acid ((1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid) is a synthetic intermediate useful for pharmaceutical synthesis.
|
-
- HY-Y0001S1
-
|
Carboxycyclopropane-d1; Cyclopropionic acid-d1
|
Isotope-Labeled Compounds
|
Others
|
|
Cyclopropane-1-carboxylic Acid-d1 is the deuterium labeled Cyclopropane-1-carboxylic Acid .
|
-
- HY-47663
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-((S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl)-1-((1S,2S)-2-methyl-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclopropyl)-1H-indole-2-carboxylic acid is a biological molecule.
|
-
- HY-N1272
-
|
|
Endogenous Metabolite
|
Others
|
|
Secaubryenol is a class of 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla. Secaubryenol does not display any cytotoxic effect at a dose of 10 μg/mL .
|
-
- HY-W127715
-
|
|
Fluorescent Dye
|
Others
|
|
Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .
|
-
- HY-W005223
-
|
(R)-(+)-Tetrahydrofuran-2-carboxylic acid
|
Biochemical Assay Reagents
|
Others
|
|
(R)-(+)-2-Tetrahydrofuroic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N15039
-
-
- HY-W074953
-
|
|
Biochemical Assay Reagents
|
Others
|
|
tert-Butyl Hydrogen Tetradecanedioate is a short linker featuring a carboxylic acid and a tert-butyl ester. Carboxylic acids can be reacted with alcohols or amines, while the tert-butyl ester can be selectively deprotected to allow for reactivity as a carboxylic acid to form esters or amides.
|
-
- HY-159478
-
-
![CHO-Ph-spiro[3.3]heptane-COOEt](//file.medchemexpress.eu/product_pic/hy-159478.gif)
- HY-W039458
-
|
|
Biochemical Assay Reagents
|
Others
|
|
10-(tert-Butoxy)-10-oxodecanoic acid is a short linker featuring a carboxylic acid and a tert-butyl ester. Carboxylic acids can be linked with alcohols or amines, while the tert-butyl ester can be selectively deprotected to allow for reactivity as a carboxylic acid to form esters or amides.
|
-
- HY-70002BR
-
|
|
Drug Metabolite
|
Cancer
|
|
Bromoxynil octanoate (Standard) is the analytical standard of Bromoxynil octanoate. This product is intended for research and analytical applications. Bromoxynil octanoate is an herbicide widely applied to maize, is potentially toxic to both animals and humans .
|
-
- HY-W002540
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-Aminopyridine-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W001937
-
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|
Biochemical Assay Reagents
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Others
|
|
[1,1'-Biphenyl]-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-32778
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-Bromopyridine-2-carboxylic acid methyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-148087
-
|
|
RXFP Receptor
|
Cardiovascular Disease
|
|
AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties .
|
-
- HY-W800686
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Acid-PEG4-NHS ester is a PEG linker with a carboxylic acid and an NHS ester. Both functional group can react with primary amine, but the carboxylic acid will need activators such as EDC or HATU.
|
-
- HY-114674
-
-
- HY-W739812
-
|
Finasteride carboxylic acid
|
Aldose Reductase
|
Cancer
|
|
Carboxy finasteride is a metabolite of the 5α-reductase inhibitor Finasteride (HY-13635). Finasteride is biotransformed by cytochrome P450 (CYP3A4) and is successively oxidized to Hydroxy finasteride and Carboxy finasteride. Carboxy finasteride is the major metabolite in urine, while Hydroxy finasteride is the major metabolite in plasma .
|
-
- HY-B1182
-
-
- HY-153987
-
|
|
STING
|
Cancer
|
|
STING agonist-33 (example 1) is an agonist of STING (stimulator of interferon genes) based on 4-ethyl-2-methylthiazole-5-carboxylic acid [1] .
|
-
- HY-W002765
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Oxo-1,2-dihydropyridine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002688
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2,6-Dichloro-5-fluoropyridine-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W800846
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-Amido-Tri-(carboxyethoxymethyl)-methane is a multifunctional reagent containing three carboxylic acids and a primary amine that is Fmoc-protected. The carboxylic acids can react with primary amine groups to form stable amide bonds. The Fmoc protecting group can be removed using piperidine, freeing up the amine for a variety of uses such as coupling with carboxylic acids to form amide bonds.
|
-
- HY-W588704
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Azidobutyric acid is a small molecule featuring an azide and a carboxylic acid. Carboxylic acids can be linked with alcohols or amides while azides can be used as click chemistry handles to react with terminal alkynes or strained cyclooctynes.
|
-
- HY-W441002
-
|
|
Liposome
|
Others
|
|
DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics .
|
-
- HY-D0934
-
|
|
Fluorescent Dye
|
Others
|
|
(5)6-Carboxytetramethylrhodamine contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid; bright, orange-fluorescent dye produces conjugates with absorption/emission maxima of ~555/580 nm .
|
-
- HY-W592008
-
|
|
Biochemical Assay Reagents
|
Others
|
|
C18-PEG5-Acid is a hybrid linker featuring a hydrophobic C18 chain and hydrophilic PEG5 spacer with a carboxylic acid. The carboxylic acid is reactive with amines to form a stable amide bond.
|
-
- HY-W671472
-
|
|
Biochemical Assay Reagents
|
Others
|
|
10-Oxononadecanedioic acid is a long alkane linker with two terminal carboxylic acid groups. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
|
-
- HY-Y0569
-
-
- HY-W800681
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Benzyloxy carbonyl-PEG4-acid is a linker with a benzyl protecting group and a carboxylic acid. The carboxylic acid can undergo reactions with primary amines with the help of activators (EDC or HATU). The benzyl protecting group can be removed via hydrogenolysis.
|
-
- HY-W440820
-
|
|
Liposome
|
Cancer
|
|
Bis(bis(2-carboxyethyl)aminopropyl)methylamine is a symmetrical branched linker featuring three tertiary amines and four carboxylic acids. Each carboxylic acid is open to forming esters or amides. It can be used in developing lipid nanoparticles.
|
-
- HY-Y0569B
-
-
- HY-76210R
-
|
|
Bacterial
Antibiotic
|
Others
|
|
Geniposidic acid (Standard) is the analytical standard of Geniposidic acid. This product is intended for research and analytical applications. Geniposidic acid has radiation protection and anti-cancer activity.
|
-
- HY-W007437
-
|
Naphthalene-2-carboxylic acid
|
Biochemical Assay Reagents
|
Others
|
|
2-Naphthoic acid is an organic compound commonly used as a raw material for dyes and the production of other chemicals. It can form dyes with other organic substances and is widely used in textile, printing and manufacturing fields. In addition, the compound is also used as a photosensitive material and a lubricant.
|
-
- HY-112107
-
|
3-Acetylthiazolidine-4-carboxylic acid
|
Phytohormone
|
Others
|
|
Folcisteine is a plant growth regulator.
|
-
- HY-W012946
-
-
- HY-W105737
-
|
|
Biochemical Assay Reagents
|
Others
|
|
18-Methoxy-18-oxooctadecanoic acid is a long alkane linker with a terminal carboxylic acid group. The terminal carboxylic acid group can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
|
-
- HY-151931
-
|
Jasmonyl-ACC
|
Phytohormone
|
Metabolic Disease
|
|
JA-ACC (Jasmonyl-ACC) is a derivative of 1-aminocyclopropane-1-carboxylic acid (ACC). ACC is the direct precursor of the plant hormone ethylene. JA-ACC inhibits root growth in Arabidopsis and the inhibition is independent of jasmonic acid (JA) signaling .
|
-
- HY-17521
-
|
SYP-L190
|
Fungal
|
Infection
|
|
Flumorph(SYP-L190) is a carboxylic acid amide (CAA) fungicide.
|
-
- HY-111604
-
|
|
Others
|
Cancer
|
|
Turbinaric acid is a cytotoxic secosqualene carboxylic acid from the brown alga Turbinaria ornata.
|
-
- HY-N12911
-
|
|
Others
|
Others
|
|
Tanzawaic acid E is a carboxylic acid and can be isolated from Penicillium steckii .
|
-
- HY-W614180
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3-Amino-2-sulfopropanoic acid is a short molecule featuring a carboxylic acid, a sulfonate group, and a primary amine. The carboxylic acid and the primary amine are free to link this molecule to larger structures while the sulfonate group provides high water solubility to this aliphatic compound.
|
-
- HY-Y0569C
-
-
- HY-W106311
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-Val-Ala-OH is a reagent consisting of a Val-Ala dipeptide with an Fmoc protecting group on its N-terminus. Carboxylic acids can be reactive with alcohols or amines, while the Fmoc protecting group can be removed with piperidine to allow for coupling with carboxylic acids to form amides.
|
-
- HY-W190752
-
|
|
Biochemical Assay Reagents
|
Others
|
|
m-PEG13-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
|
-
- HY-34643
-
|
Hept-6-ynoic acid
|
Biochemical Assay Reagents
|
Others
|
|
6-Heptynoic acid (Hept-6-ynoic acid) is a reagent with an alkyne group and a carboxylic acid. The terminal carboxylic acid can form amide bond with primary amines (activation is needed). The alkyne can form triazole linkage with azide containing molecules via copper catalyzed reactions.
|
-
- HY-103331
-
-
- HY-129503
-
|
|
Drug Intermediate
|
Others
|
|
2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .
|
-
- HY-12407
-
|
|
VD/VDR
|
Metabolic Disease
|
|
ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure VDR antagonist with a Kd value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor .
|
-
- HY-D1096
-
|
|
Fluorescent Dye
|
|
|
Sulfo-Cy5 diacid potassium is a water-soluble, inactive Cy5 carboxylic acid.
|
-
- HY-Y0030
-
|
3-hydroxypyridine-2-carboxylic acid
|
Biochemical Assay Reagents
Drug Intermediate
|
Infection
|
|
3-Hydroxypicolinic acid is a matrix. 3-Hydroxypicolinic acid coordinates with metal ions such as copper to form complexes with cytotoxic and antimycobacterial activity. 3-Hydroxypicolinic acid is used for the analysis of oligodeoxynucleotides in matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). 3-Hydroxypicolinic acid is useful for nucleic acid analysis and anti-tuberculosis compound development .
|
-
- HY-D2754
-
|
|
Fluorescent Dye
|
Others
|
|
BP Light 550 acid is a vibrant orange-to-red fluorochrome with better performance t han other rhodamine derivatives, including BP Fluor 555, TRITC, and Cy3 dye for fluorescent applications. The high water solubility of BP Light Fluors means that a high dye-to-protein ratio can be attained without causing precipitation of the conjugates.
|
-
- HY-W002139
-
|
6-Methylpyridine-2-carboxylic acid
|
Biochemical Assay Reagents
|
Others
|
|
6-Methylpicolinic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W190910
-
|
|
Biochemical Assay Reagents
|
Others
|
|
AZD-PEG2-acid is a PEG linker containing an AZD group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-33013S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Clevidipine impurity 24- 13C,d3 is 13C and deuterium labeled 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid .
|
-
- HY-W800713
-
|
|
Biochemical Assay Reagents
|
Others
|
|
SPDP-Gly-Pro-acid is a linker with SPDP and carboxylic acid moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-P2831
-
|
CESs
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Esterase, pig liver (CESs), namely carboxylate hydrolases, are widely distributed in nature, commonly found in mammalian liver, and often used in biochemical research. Esterase catalyzes the hydrolysis of a variety of endogenous and exogenous substrates, including esters, thioesters, carbamates, and amides, hydrolyzing carboxylic acid esters to the corresponding alcohols and carboxylic acids .
|
-
- HY-W286613
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-Boc-Biocytin is a biotin PEG linker containing a carboxylic group and Boc-protected amine. Reaction of carboxylic with primary amino (-NH2) forms stable, irreversible amide bonds. The Boc group can be deprotected under acidic condition to obtain the free amine which can be used for further conjugations.
|
-
- HY-W190951
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3-((2-(2,2,2-Trifluoroacetamido)ethyl)disulfanyl)propanoic acid is a cleavable linker containing a carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The disulfide bond can be cleaved via reduction reactions.
|
-
- HY-130755
-
|
CHCoA; Cyclohexanecarboxyl-CoA; Cyclohexanoyl CoA
|
Endogenous Metabolite
|
Others
|
|
Cyclohexanoyl coenzyme A is the active form of cyclohexane carboxylic acid (CHC) from anaerobic degradation in Rhodopseudomonas palustris .
|
-
- HY-W143822
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-(Tritylthio)hexanoic acid is a linker with a Tst group and a terminal carboxylic acid. The Tst group can be deprotected under acidic conditions to obtain the free thiol which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-121029
-
|
KRP-104
|
Histone Methyltransferase
|
Metabolic Disease
|
|
Bisegliptin (KRP-104) is a small molecule compound with antidiabetic activity. Bisegliptin is metabolized mainly by converting the cyano group to the carboxylic acid form, and DPP-4 plays a partial role in its metabolism. The carboxylic acid metabolite of bisegliptin can be detected both in vivo and in vitro. In rat experiments, the plasma concentration of the carboxylic acid metabolite of bisegliptin was affected by other DPP inhibitors, showing the complexity of its metabolic process. The amide intermediate of bisegliptin was detected both in vivo and in vitro, and its conversion rate was significantly faster than that of the parent compound when incubated with DPP-4 .
|
-
- HY-W713416
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Isoleukotoxin Diol is the oxidation product of linoleic acid, with a pair of hydroxly groups on the unsaturated fatty acid tail and a carboxylic acid as the polar head.
|
-
- HY-162125
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
AT2 receptor ligand-1(compound 14) is a potent angiotensin AT2 receptor ligand with the Ki 4.9 nM. AT2 receptor ligand-1 shows high stability in microsomes of the sulfonamide ligands .
|
-
- HY-W012946S
-
-
- HY-W190916
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3-[[2-[(4-azidobenzoyl)amino]ethyl]dithio]propanoicacid contains an aryl azide, a cleavable disulfide bond, and a carboxylic acid. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond. The disulfide bond can be cleaved via reducing agents.
|
-
- HY-W190934
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-Ala-Pro-OH is a linker with an Fmoc-protected amine and a terminal carboxylic acid. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-140015A
-
|
|
PROTAC Linkers
|
Cancer
|
|
(S)-TCO-PEG3-acid is a click chemistry PEG linker with a terminal carboxylic acid(COOH) group. The terminal carboxylic acid is reactive with primary amine groups to form a stable amide bond. (S)-TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-W001578
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1-Adamantaneacetic acid is an aliphatic carboxylic acid that can be used as an acylating agent, commonly found in chemical synthesis .
|
-
- HY-W011412
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TSTU is able to converse carboxylic acid to the corresponding N-hydroxysuccinimidyl (NHS) ester, and is utilized as coupling reagent in peptide chemistry .
|
-
- HY-W176477
-
|
Octyldecanoic acid
|
Biochemical Assay Reagents
|
Others
|
|
2-Octyldecanoic acid (Octyldecanoic acid) is a saturated fatty acid with a long aliphatic tail consisting of 17 carbon atoms and a carboxylic acid group.
|
-
- HY-W761299
-
-
- HY-N0140
-
|
Prunol; Urson; Malol
|
Autophagy
Endogenous Metabolite
|
Cancer
|
|
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
|
-
- HY-161590
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
AHD/BSA is the antigen-adjuvant conjugate of AHD (furan-2-carboxylic acid) and Bovine Serum Albumin (BSA). By conjugating the antigen with the protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or destroy the main epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
|
-
- HY-W572763
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Tos-PEG6-acid is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
|
-
- HY-W160298
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-Cbz-7-Aminoheptanoic acid is a six carbon linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
|
-
- HY-W012946R
-
|
|
ATP Citrate Lyase
Acyltransferase
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Furoic acid (Standard) is the analytical standard of 2-Furoic acid. This product is intended for research and analytical applications. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats .
|
-
- HY-23629
-
|
|
PROTAC Linkers
|
Cancer
|
|
16-Aminohexadecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. 16-Aminohexadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
|
-
- HY-W401143
-
|
|
PROTAC Linkers
|
Cancer
|
|
15-Aminopentadecanoic Acid can be used as a PROTAC linker in the synthesis of PROTACs. 15-Aminopentadecanoic Acid is an alkane chain with terminal carboxlic acid and amine groups. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
|
-
- HY-W800794
-
|
DPPE-NG; 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(glutaryl)
|
Liposome
|
Cancer
|
|
16:0 Glutaryl PE is is a carboxylic acid-functionalized lipid with a three carbon linker to a phosphoethanolamine bound to two palmitic acid tails.
|
-
- HY-W800792
-
|
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl)
|
Liposome
|
Cancer
|
|
18:1 Succinyl PE is a carboxylic acid-functionalized lipid with a two carbon linker to a phosphoethanolamine bound to two oleic acid tails.
|
-
- HY-W800793
-
|
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl)
|
Liposome
|
Cancer
|
|
16:0 Succinyl PE is a carboxylic acid-functionalized lipid with a two carbon linker to a phosphoethanolamine bound to two palmitic acid tails.
|
-
- HY-12384
-
|
|
COX
|
Inflammation/Immunology
|
|
Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.
|
-
- HY-W800795
-
|
DOPE-NG; 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(dodecanoyl)
|
Liposome
|
Cancer
|
|
18:1 Dodecanyl PE is a carboxylic acid-functionalized lipid with a ten carbon linker to a phosphoethanolamine bound to two oleic acid tails.
|
-
- HY-Y0912
-
|
N-HBTU
|
Biochemical Assay Reagents
|
Others
|
|
HBTU is a coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis .
|
-
- HY-W800844
-
|
|
Biochemical Assay Reagents
|
Others
|
|
NH-bis(PEG8-OH) is a homobifunctional reagent containing two alcohols joined together by a secondary amine. The alcohols can be used in a variety of ways such as in forming esters with carboxylic acids, while the secondary amine can be used as a nucleophile in linking with ketones, aldehydes, and carboxylic acids. The PEG spacers make this molecule water-soluble, potentially altering its DMPK properties.
|
-
- HY-W800750
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TCO-PEG2-acid is a click chemistry linker containing a TCO (trans-cycloctene) and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC. TCO reagent is highly reactive with tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-DA reaction. The hydrophilic PEG spacer increases solubility in aqueous media.
|
-
- HY-W800632
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Azide-TFP-Amide-SS-propionic acid contains an aryl azide, a cleavable disulfide bond, and a carboxylic acid. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. Fluoro helps to stabilize the free radical intermediate. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond. The disulfide bond can be cleaved via reducing agents.
|
-
- HY-W800706
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Azidobutanamide-tri-(carboxyethoxymethyl)-methane is a aqueous soluble PEG linker with an azide group with three terminal carboxylic acids. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W105727
-
|
|
PROTAC Linkers
|
Cancer
|
|
9-Aminononanoic acid can be used as a PROTAC linker and other conjugation in the synthesis of PROTACs. 9-Aminononanoic acid is an alkane chain with terminal carboxlic acid and amine groups. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
|
-
- HY-75814
-
|
p-Isopropoxybenzoic acid
|
Biochemical Assay Reagents
|
Others
|
|
4-Isopropoxybenzoic acid (p-Isopropoxybenzoic acid) is an aromatic carboxylic acid organic compound that can be used as a synthetic intermediate in organic synthesis such as pesticides .
|
-
- HY-111197
-
-
- HY-133652
-
|
|
Drug Intermediate
|
Others
|
|
2,3-Dibromoacrylic acid is dibromo product based on acrylic acid. Acrylic acid is the simplest unsaturated carboxylic acid and can be used as a chemical intermediate.
|
-
- HY-W190929
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Diethyl 4-aminoheptanedioate contains a primary amine which can react with carboxylic acids, activated NHS esters and other carbonyls.
|
-
- HY-41404
-
|
2H-1,3-benzodioxole-5-carboxylic acid
|
Cytochrome P450
Interleukin Related
EGFR
IGF-1R
|
Infection
Others
Cancer
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|
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .
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-
- HY-40013
-
|
1-Boc-Piperidine-4-carboxylic acid
|
Biochemical Assay Reagents
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Others
|
|
Boc-Inp-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-76104
-
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ADC Linker
PROTAC Linkers
|
Cancer
|
|
cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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-
- HY-W105744
-
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PROTAC Linkers
|
Cancer
|
|
10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. 10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
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-
- HY-W800635
-
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Biochemical Assay Reagents
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Others
|
|
4-Azide-TFP-Amide-PEG4-acid contains an aryl azide and a carboxylic acid with a PEG spacer to increase aqueous solubility and decrease steric hinderance during ligation. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. Fluoro helps to stabilize the free radical intermediate. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond.
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-
- HY-D1970
-
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|
Fluorescent Dye
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Others
|
|
ATTO 700 Cadaverin is a cadaverine derivative of ATTO 700 for reactions of carboxylic acids, aldehydes and ketones with maximum excitation/emission wavelengths: 700/716 nm.
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-
- HY-161005
-
|
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Others
|
Metabolic Disease
|
|
TETS-Methyl benzoate(compound 2j) is a haptendirectly conjugated to the carrier protein via carboxylic acid function using the standard activated ester method .
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-
- HY-D2070
-
|
|
Fluorescent Dye
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Others
|
|
ATTO 680 cadaverin is a cadaverine derivative of ATTO 680, used for carboxylic acid, aldehyde and ketone reactions, maximum excitation/emission wavelength: 681/698 nm.
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-
- HY-D2055
-
|
|
Fluorescent Dye
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Others
|
|
ATTO 532 cadaverin is a cadaverine derivative of ATTO 532, used for carboxylic acid, aldehyde and ketone reactions, maximum excitation/emission wavelength: 532/552 nm.
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-
- HY-D2039
-
|
|
Fluorescent Dye
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Others
|
|
ATTO 550 cadaverin is a cadaverine derivative of ATTO 550, used for carboxylic acid, aldehyde and ketone reactions, maximum excitation/emission wavelength: 554/576 nm.
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-
- HY-W800722
-
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|
Biochemical Assay Reagents
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Others
|
|
N-(PEG1-acid)-L-Lysine-amido-Mal is a PEG based linker with terminal malimide and carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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-
- HY-131699
-
|
|
Biochemical Assay Reagents
|
Others
|
|
t-Butyl ester-PEG4-CH2COOH is a PEG linker containing a t-butyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl group can be deprotected under acidic conditions.
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-
- HY-W097128
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-12-aminododecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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-
- HY-W800813
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Carboxy-Amido-PEG5-N-Boc is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-W591982
-
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|
Biochemical Assay Reagents
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Others
|
|
t-Boc-N-amido-PEG12-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-135717
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
Norbiotinamine is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction .
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-
- HY-135717A
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
Norbiotinamine hydrochloride is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction .
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-
- HY-W591325
-
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|
Biochemical Assay Reagents
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Others
|
|
4-((5-Nitropyridin-2-yl)disulfanyl)pentanoic acid is a synthetic building block with terminal nitro and carboxylic acid groups with a disulfide bond in the center.
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-
- HY-141161A
-
|
|
PROTAC Linkers
|
Cancer
|
|
(S)-TCO-PEG8-acid is a click chemistry PEG linker with a terminal carboxylic acid(COOH) group. The terminal carboxylic acid is reactive with primary amine groups to form a stable amide bond. (S)-TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. (S)-TCO-PEG8-acid is longer than (S)-TCO-PEG3-acid .
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-
- HY-400361
-
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|
Biochemical Assay Reagents
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Others
|
|
BocNH-PEG2-CH2COONHS ester is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-W111228
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-9-aminononanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and and other conjugation applications. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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-
- HY-170505
-
|
|
Microtubule/Tubulin
Herbicide
|
Others
|
|
Icafolin-methyl is a plant-specific herbicide and an inhibitor of tubulin polymerization. It is metabolized to carboxylic acid icafolin in plants, potentially inhibiting tubulin polymerization by binding to β-tubulin .
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-
- HY-136217
-
|
|
P-glycoprotein
|
Cancer
|
|
PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine .
|
-
- HY-12397
-
|
|
VD/VDR
|
Endocrinology
|
|
ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character .
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-
- HY-W097110
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-11-aminoundecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-11-aminoundecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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-
- HY-W800708
-
|
|
Biochemical Assay Reagents
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Others
|
|
N-(TCO)-N-bis(PEG4-acid) is a branched click chemistry reagent with a terminal TCO group and two terminal carboxylic acids. This reagent can react with tetrazine-containing molecule to form a stable covalent bond . The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acids can react with primary amino groups in the presence of activators (e.g. EDC, HATU ).
|
-
- HY-W403327
-
|
|
Biochemical Assay Reagents
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Others
|
|
CbzNH-PEG4-CH2COOH is a PEG linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
|
-
- HY-W591968
-
|
|
PROTAC Linkers
|
Cancer
|
|
14-(Fmoc-amino)-tetradecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. 14-(Fmoc-amino)-tetradecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W009030
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-129503S
-
|
|
Isotope-Labeled Compounds
Drug Intermediate
|
Others
|
|
2-Heptyl-4-quinolone- 13C6 is the 13C-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .
|
-
- HY-129503S1
-
|
|
Isotope-Labeled Compounds
Drug Intermediate
|
Others
|
|
2-Heptyl-4-quinolone- 15N is the 15N-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .
|
-
- HY-W009056
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-7-amino-heptanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. Fmoc-7-amino-heptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-170227
-
|
|
Phosphodiesterase (PDE)
TGF-β Receptor
|
Inflammation/Immunology
|
|
Autotaxin-IN-7 (45), a pyridine-2-carboxylic derivative, demonstrates subnanomolar ATX inhibition (IC50 = 0.086 nM), with a favorable heart safety profile (hERG > 30 μM) and minimal fibroblast toxicity. Autotaxin-IN-7 (45) suppresses the TGF-β/Smad signaling pathway, downregulating α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) is used in the research for pulmonary fibrosis .
|
-
- HY-W073382
-
|
Bis–sulfone acid
|
Biochemical Assay Reagents
|
Others
|
|
4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to “staple” two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.
|
-
- HY-163008
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
Dicamba-5-aminopentanoic acid (DCc) is an immunizing and heterologous hapten, designed using the carboxylic acid group of dicamba to introduce a spacer arm for a better exposure of the herbicide's structure .
|
-
- HY-Y0569BR
-
|
|
Fungal
Endogenous Metabolite
|
Cancer
|
|
D-Gluconic acid (calcium hydrate) (Standard) is the analytical standard of D-Gluconic acid (calcium hydrate). This product is intended for research and analytical applications. D-Gluconic acid calcium hydrate is the carboxylic acid by the oxidation with antiseptic and chelating properties.
|
-
- HY-W017195
-
|
Propan-2-yl benzoate
|
Biochemical Assay Reagents
|
Others
|
|
Isopropyl benzoate is a class of esters consisting of a benzene ring and an isopropyl group attached to a carboxylic acid group. Isopropyl benzoate can be used as an inducer to biosynthesize phloroglucinol in E. coli .
|
-
- HY-Y0569CR
-
|
|
Endogenous Metabolite
Fungal
|
Infection
Cancer
|
|
D-Gluconic acid (potassium) (Standard) is the analytical standard of D-Gluconic acid (potassium). This product is intended for research and analytical applications. D-Gluconic acid potassium is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties .
|
-
- HY-W441005
-
|
|
Liposome
|
Cancer
|
|
Amino-Gly-Gly-DSPE (hydrochloride) is a specially modified phospholipid that has been used to synthesize liposomes. The terminal amine is reactive with an NHS ester compound or carboxylic acid molecule in the presence of activator, such as HATU or EDC.
|
-
- HY-12287
-
-
- HY-W700975
-
|
|
Biochemical Assay Reagents
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Others
|
|
12-Ketostearic acid sodium is a synthetic membrane probe that binds to the hydrophobic regions in lipid bilayer membranes. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.
|
-
- HY-W800721
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyltetrazine-amido-bis-(carboxyethoxymethyl)-methane is a click chemistry PEG reagent which contains three carboxylic acid groups and a methyltetrazine group. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W800667
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Hydroxy-PEG4-acid sodium is a PEG linker containing a hydroxyl group with a terminal carboxylic acid (as sodium salt form). The free acid form is not stable due to the reaction of OH with PEG-COOH group to form polymer. The sodium salt form is stable for storage and shipping. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
|
-
- HY-W800709
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-(acid-PEG10)-N-bis(PEG10-azide) is a very popular PEG reagent containing a terminal carboxylic acid and two azide groups. The hydrophilic PEG spacer increases solubility in aqueous media. The azide groups can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-132828
-
|
LT3001; DHDMIQK(KAP)
|
P-selectin
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities .
|
-
- HY-40135
-
|
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
|
Endogenous Metabolite
|
Others
|
|
L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
|
-
- HY-I0422
-
|
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
|
Biochemical Assay Reagents
|
Others
|
|
L-Porretine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-115773
-
|
NMTPRO; N-Nitroso-2-methylthiazolidine 4-carboxylic acid; N-nitrosomethylthioproline
|
Endogenous Metabolite
|
Metabolic Disease
|
|
NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid. NMTCA can be used as an indicator of endogenous nitrosation by gas chromatography-thermalenergyanalysis .
|
-
- HY-W591461
-
|
|
Liposome
|
Cancer
|
|
DSPE-PEG-COOH, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.
|
-
- HY-103684
-
|
Real Thiol-NH2
|
Fluorescent Dye
|
Neurological Disease
|
|
RT-NH2 is a RealThiol prototype without the carboxylic acid groups. RT-NH2 is fairly hydrophobic and cannot distribute in the nucleus, which is a hallmark of protein binding for fluorescent probe.
|
-
- HY-133883
-
|
|
Fluorescent Dye
|
Others
|
|
Cyanine7.5 amine is a NIR fluorescent dye. Cyanine7.5 amine contains free amino group which can be used coupled with activated carboxylic acid derivatives.
|
-
- HY-132270
-
|
|
Fluorescent Dye
|
Others
|
|
FAM amine, 5-isomer is a fluorescein linker that undergoes enzymatic transamination. The addition of the amine group makes the compound more reactive with carboxylic acids, activated NHS ester and other carbonyl groups.
|
-
- HY-W998707
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA amine, 5-isomer hydrochloride is a rhodamine dye with excitation/emission maximum 553/575 nm. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
-
- HY-N0140R
-
|
|
Autophagy
Endogenous Metabolite
|
Cancer
|
|
Ursolic acid (Standard) is the analytical standard of Ursolic acid. This product is intended for research and analytical applications. Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
|
-
- HY-W574509
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
Tos-PEG2-acid (compound 30) is a PEG linker containing a tosyl group and a terminal carboxylic acid. Tos-PEG2-acid can react with primary amine groups .
|
-
- HY-W800718
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyltetrazine-amido-Tri-(acid-PEG1-ethoxymethyl)-methane is a click chemistry PEG reagent which contains three carboxylic acid groups and a methyltetrazine group. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-Y1644
-
|
(E)-2-Butenoic acid; trans-2-Butenoic acid; trans-Crotonic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives .
|
-
- HY-163169
-
|
|
Ligands for E3 Ligase
|
Others
|
|
Phenyl-glutarimide 4 ’-oxyacetic acid is a carboxylic acid-functionalized cerebellar ligand that can be used in the development of PROTAC deactivators. Phenyl-glutarimide 4 ’-oxyacetic acid binds to PROTAC has better hydrolytic stability and efficacy .
|
-
- HY-W067425
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-(4-Hydroxyphenyl)propionic acid (Compound 1) is an aromatic carboxylic acid, which can be converted into its R and S glucosyl esters and glucosides by root culture of P. ginseng (Pg-1) .
|
-
- HY-77593
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-W585386
-
|
|
Fluorescent Dye
|
Others
|
|
BDP TMR amine hydrochloride is a BDP dye linker is very bright which makes it useful for processes such as determining quantum yield. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
-
- HY-W090940
-
|
|
ADC Linker
|
Cancer
|
|
H-Gly-Gly-Phe-OH is a tripeptide linker that may be used in the creation of antibody drug conjugates (ADCs). The N-terminal of the glycine tripeptide is free to perform a variety of reactions such as couplings with carboxylic acids or NHS esters.
|
-
- HY-140535
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Boc-NH-Bis(acid-PEG1-m) is a PEG derivative contains carboxylic acid moieties. Boc-NH-Bis(acid-PEG1-m) can be conjugated with amine containing molecule .
|
-
- HY-W1048542
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-NH-PEG-COOH (MW1000) is a PEG product containing two Fmoc-protected amines and a carboxylic acid. Fmoc-NH-PEG-COOH (MW1000) is an important cross-linking agent with PEG chains .
|
-
- HY-P2736
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes .
|
-
- HY-136480
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Chrysamine G, a carboxylic acid analogue of Congo Red, can be used as a probe of amyloid deposition in Alzheimer's disease. Chrysamine G also can inhibit Aβ-induced toxicity in PC12 cells .
|
-
- HY-W585403
-
|
|
Fluorescent Dye
|
Others
|
|
BDP 630/650 hydrazide hydrochloride is a BDP linker containing a carboxylic acid. The BDP 630/650 has similar excitation and emission wavelengths to Cy5. Hydrazide moieties react with aldehydes to form semi-permanent hydrazone bonds.
|
-
- HY-155442
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
MIQ-N-succinate is a hapten with a four-carbon chain. MIQ-N-succinate consist of MIQ and succinic anhydride. MIQ-N-succinate has a carboxylic acid end group to attach to the lysine residues on the carrier proteins .
|
-
- HY-D1658
-
|
|
Fluorescent Dye
|
Others
|
|
BDP 581/591 amine hydrochloride is a BODIPY dye linker. BDP 581/591 is a universal, photostable fluorophore. The addition of the amine group allows for the compound to react with carboxylic acids, activated NHS esters and other carbonyl groups .
|
-
- HY-172284
-
|
|
Fluorescent Dye
|
Others
|
|
6-TAMRA cadaverine has achieved prominence as a dye for oligonucleotide labeling and automated DNA sequencing applications. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.
|
-
- HY-103570
-
|
|
mGluR
|
Neurological Disease
|
|
MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) .
|
-
- HY-117923
-
|
|
mTOR
PI3K
|
Cancer
|
|
PF-06465603 is a highly potent and selective ATP-competitive kinase inhibitor and a class 1 PI3K and mTOR inhibitor. PF-06465603 is a metabolite of PF-04691502 with a terminal carboxylic acid structure .
|
-
- HY-D0036
-
|
4-Bromomethyl-7-methoxycoumarin
|
Fluorescent Dye
|
Others
|
|
Br-Mmc (4-Bromomethyl-7-methoxycoumarin) is often used as fluorescent label for the determination of compounds possessing a carboxylic group. Br-Mmc is used for the determination fatty acids by TLC or HPLC .
|
-
- HY-D2764
-
|
|
Fluorescent Dye
|
Others
|
|
Difluorocarboxyfluorescein cadaverine, 5-isomer is a carbonyl reactive building block used to modify carboxylic groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond.
|
-
- HY-W800651
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-SS-Amine hydrochloride is a cleavable biotinylation reagent. The amine group can react with carboxylic acids, activated NHS esters and other carbonyl groups. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP.
|
-
- HY-140531A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-(Biotin-PEG4)-N-bis(PEG4-acid) hydrochloride is a branched biotinylation reagent for labeling. The carboxylic acid groups can react with primary amines in the presence of EDC and HATU to form stable amide bonds.
|
-
- HY-N0823
-
-
- HY-W016819B
-
|
5-Fluorouracil-6-carboxylic acid Mono(hydrate); 5-FOA; 5-fluoro OA
|
Thymidylate Synthase
Parasite
|
Infection
|
|
5-Fluoroorotic acid monohydrate is the monohydrate salt form of 5-Fluoroorotic acid (HY-W016819).
5-Fluoroorotic acid monohydrate is the inhibitor for thymidylate synthase that acts as a selective agent in yeast molecular genetics. 5-Fluoroorotic acid monohydrate exhibits antimalarial activity .
|
-
- HY-161006
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
TETS-C4-acid (Compound 2d) is a hapten coupled directly to a carrier protein through a carboxylic acid functionality. TETS-C4-acid (Compound 2d) can be used to detect tetramethylenedisulfotetramine (TETS) .
|
-
- HY-W585390
-
|
|
Fluorescent Dye
|
Others
|
|
BDP 581/591 hydrazide hydrochloride is a BDP linker containing a hydrazide. The BDP 581/591 is very photostable. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-115435
-
|
DMPS-Na; Dimyristoyl phosphatidylserine sodium
|
Liposome
|
Cancer
|
|
1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine sodium is an anionic phospholipid with myristic acid tails (14:0) and contains a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of liposome.
|
-
- HY-149707
-
|
|
ICMT
|
Cancer
|
|
ICMT-IN-21 (compound 6ag) is an ICMT inhibitor (IC50=8.8 μM), a sulfonamide-modified farnesyl cysteine (SMFC). The farnesyl and carboxylic acid motifs of ICMT-IN-21 are important structures for inhibiting ICMT .
|
-
- HY-W190918
-
|
|
Biochemical Assay Reagents
|
Others
|
|
endo-BCN-PEG4-amine is a click chemistry crosslinker reagent. The BCN groupis very reactive with azide-tagged molecules. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
-
- HY-164569
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
NH2 DOTA-GA is a DOTA-based metal chelator that can be used to prepare radionuclide drug conjugates (RDCs) whose carboxylic acid groups can complex metal ions. For example, NH2 DOTA-GA complexes Gd(III) ions.
|
-
- HY-W591352
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-5-(C6-amine) is a PROTAC building block that contains an E3 ligase ligand substituted with a terminal amine group. The amine group can react with NHS ester group or carboxylic acid in the presence of EDC or HATU.
|
-
- HY-W190915
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4,7,10,13,16–Pentaoxanonadecane-1,19-diamine is a PEG based linker with two terminal amine groups. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
-
- HY-147180
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Dansyl-DL-valine cyclohexylammonium is a salt form of Dansyl-DL-valine. Dansyl-DL-valine cyclohexylammonium can be used as analyte in chromatographic separation and separation column for the separation of enantiomers and diastereomers for dansyl amino acids, aromatic carboxylic acids, and isoxazolines .
|
-
- HY-W585383
-
|
|
Fluorescent Dye
|
Others
|
|
BDP TR hydrazide is a BDP TR linker with a hydrazide group. The BDP dye is popular for the microscopy and fluorescence polarization assays. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W800825
-
|
|
Liposome
|
Cancer
|
|
Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
|
-
- HY-W591379
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Amino-PEG19-amine is a PEG linker containing two amine functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.
|
-
- HY-W127549
-
|
cis-6-Octadecenoic acid
|
Biochemical Assay Reagents
|
Others
|
|
Petroselinic acid sodium is an organic compound belonging to the class of carboxylic acids. Petroselinic acid sodium has several applications in the cosmetic and personal care industries, especially as an emulsifier and conditioning agent in skin and hair care products. In addition, it has potential utility in inhibiting inflammation-related diseases and cancer.
|
-
- HY-W190904
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Amino-1,3-bis(tert-butyldimethylsilanoxy)propane has a TBDMS, acid labile protecting group. TBDMS is used for the protection of alcohol groups. The primary amine is able to react with carboxylic acids, active NHS esters and other carbonyl compounds.
|
-
- HY-W800688
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Acid-PEG5-Amide-Tri(3-methoxypropanamide-PEG4-Azide) Methane is a branched PEG linker with a terminal carboxylic acid group and three terminal azides. The azide groups enables PEGylation via Click Chemistry.
|
-
- HY-W800715
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(Acid-PEG10)-Tri-(Azide-PEG10-ethoxymethyl)-methane can undergo Click Chemistry with Propargyl, BCN or DBCO reagents. Carboxylic acid (CO2H) group is reactive with primary amino groups in the presence of EDCor HATU.
|
-
- HY-W154175
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Boc-DODA is a linker containing a Boc-protected amino group and a terminal amine. The Boc group can be deprotected under mild acidic conditions to form the free amine. The terminal amine is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
-
- HY-128851B
-
|
|
Endogenous Metabolite
Fatty Acid Synthase (FASN)
|
Metabolic Disease
Cancer
|
|
Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .
|
-
- HY-128851
-
|
|
Endogenous Metabolite
Fatty Acid Synthase (FASN)
|
Metabolic Disease
Cancer
|
|
Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .
|
-
- HY-128851A
-
|
|
Endogenous Metabolite
Fatty Acid Synthase (FASN)
|
Metabolic Disease
Cancer
|
|
Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .
|
-
- HY-W800676
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-N-bis(PEG4-acid) is a branched click chemistry reagent. The DBCO group enables copper-free Click Chemistry reactions. carboxylic acid groups allows for reactions with primary amine groups using activators such as EDC or HATU to form a stable amide bond.
|
-
- HY-W590569
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Azido-PEG12-amine is a water soluble PEG compound. The azide group enables Click Chemistry. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The hydrophilic PEG arm increases solubility in aqueous media.
|
-
- HY-W012971
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-Amino-1-pentanol is a linker containing a hydroxyl group and amine group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
-
- HY-W835383
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-Cy5.5-COOH is a sulfonated Cy5.5 fluorescent dye containing a sulfonic acid group and a carboxylic acid group. The fluorescence wavelength of Sulfo-Cy5.5-COOH is in the near-infrared region and has strong penetrating power.
|
-
- HY-G0023
-
|
Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib
|
Drug Metabolite
|
Others
|
|
Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
|
-
- HY-B0024
-
|
NM441
|
Bacterial
Antibiotic
|
Infection
|
|
Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a proagent of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis .
|
-
- HY-W591353
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Thalidomide-5-(PEG2-amine) is a PROTAC building block that contains an E3 ligase ligand substituted with a terminal amine group. The amine group can react with NHS ester group or carboxylic acid in the presence of EDC or HATU. The PEG spacer improves water solubility.
|
-
- HY-W440986
-
|
DSPS sodium
|
Liposome
|
Others
|
|
Distearoylphosphatidylserine sodium is an anionic phospholipid with stearic acid tails (18:0) and contains a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of lipid-mixing vesicles, liposome, or artificial membrane. Due to the medium size of fatty acid chain, DLPS is used to form thinner membranes/walls.
|
-
- HY-141651
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C3-COOH (compound 28i) is a carboxylic acid derivative of the VHL E3 ubiquitin ligase ligand-Linker conjugate. (S,R,S)-AHPC-C3-COOH can be used to synthesize PROTACs .
|
-
- HY-W440985
-
|
1,2-dilauroyl-sn-glycero-3-phospho-L-serine
|
Liposome
|
Cancer
|
|
DLPS is an anionic phospholipid with lauric acid tails (12:0) and contains a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of lipid-mixing vesicles, liposome, or artificial membrane. Due to the medium size of fatty acid chain, DLPS is used to form thinner membranes/walls.
|
-
- HY-W479025
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-DODA hydrochloride is a linker with an Fmoc-protected amine and a terminal amine group. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
-
- HY-W590588
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Diethyl acetal-PEG4-amine is a PEG reagent containing an amino (NH2) group and a terminal diethyl acetal protecting group, which can be deprotected to form the free aldehyde. NH2 group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.
|
-
- HY-156774
-
|
|
PROTACs
Epigenetic Reader Domain
|
Others
|
|
CCW 28-3 is a PROTAC-based BRD4 degrader in a proteasome- and RNF4-dependent manner (Pink: JQ-1 (carboxylic acid) (HY-78695); Black: linker (HY-170384); Blue: RNF4 ligand CCW16 (HY-143346)) .
|
-
- HY-W591965
-
|
|
Biochemical Assay Reagents
|
Others
|
|
t-Boc-Aminooxy-pentane-amine is a linker containing an aminooxy group and a primary amine. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
-
- HY-W018728S
-
-
- HY-130695
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids .
|
-
- HY-N0823R
-
|
|
NO Synthase
AMPK
Keap1-Nrf2
Xanthine Oxidase
Apoptosis
|
Cardiovascular Disease
Inflammation/Immunology
|
|
Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .
|
-
- HY-W088501
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(E)-Pent-3-enoic acidIt is an unsaturated carboxylic acid. (E)-Pent-3-enoic acidAs a starting material for various chemical reactions including esterification, oxidation and reduction. (E)-Pent-3-enoic acidIt has potential use as a flavoring agent in the food industry.
|
-
- HY-W153502
-
|
|
Biochemical Assay Reagents
|
Others
|
|
MeNH-PEG2-OH is a PEG linker containing a hydroxyl group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc.
|
-
- HY-W190947
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Iodoacetamido-PEG8-acid is a PEG reagent containing an Iodoacetamide group and a carboxlic acid moiety. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group.
|
-
- HY-W714524
-
|
1,2-POPS; 1,2-POPS; 2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine sodium; 1-Hexadecanoyl-2--(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine sodium salt
|
Liposome
|
Metabolic Disease
|
|
2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine sodium is an anionic phospholipid with oleic acid (18:1) and palmitic acid (16:0) tails containing a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of lipid-mixing vesicles, liposomes, and artificial membranes.
|
-
- HY-W130607
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Biotinyl-8-amino-3,6-dioxaoctanoic acid is a biotinylating reagent linked with a PEG chain for improved water solubility. Biotin is an affinity ligand and it is used in biochemical applications such as pull-down assays or for ligating with streptavidin proteins. The carboxylic group can react with amine-containing molecules in the presence of activators such as HATU.
|
-
- HY-W510032
-
|
|
Biochemical Assay Reagents
|
Infection
|
|
9-Ethoxy-9-oxononanoic acid is a C-11 fatty acid that has an ethyl ester group at the end of the saturated tail. The carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Azelaic Acid Monoethyl Ester has antifungal activity against Cladosporium herbarum.
|
-
- HY-W092344
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1,5-Bis-Boc-1,5,9-triazanonane is a linker containing two Boc-protected amino groups and a terminal amine. The Boc groups can be deprotected under mild acidic conditions to form the free amines. The terminal amine is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
-
- HY-169081
-
|
|
PROTACs
Molecular Glues
|
Others
|
|
QS-57 is a PROTAC targeting BRD4. QS-57 can be used as a 14-3-3 molecular glue. (Red: EN171 (HY-W1005067), black: (2-Aminoethyl) carbamic acid (HY-W398806), Blue: JQ-1 (carboxylic acid) (HY-78695)) .
|
-
- HY-W1113139
-
|
|
Biochemical Assay Reagents
|
Others
|
|
H2N-PEG4-C3-OH is a PEG linker with a terminal amino group that can react with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. Hydroxyl group can react with a variety of functional groups. PEG spacer improves the compound's aqueous solubility.
|
-
- HY-42213
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N1,N4-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-42222
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N1,N5-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-W800650
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Aminooxy-PEG1-amine is a chemical reagent containing an aminooxy group and a primary amine. The aminooxy group is reactive with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The amino group is reactive withactivated NHS esters, or carboxylic acid in the presence of coupling reagent EDC. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term.
|
-
- HY-WAA0302
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1,4-Bis-Boc-1,4,7-triazaheptane is a PEG derivative containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-158024
-
|
|
NOD-like Receptor (NLR)
|
Neurological Disease
|
|
NDT-19795 is an effective inhibitor of the NLRP3 inflammasome with an IC50 value of 66 nM in the PBMC method and 4.7 μM in the WB method. NDT-19795 is a carboxylic acid-active substance that can be converted from NT-0796 (HY-156438) within cells. NDT-19795 can be used for the study of neurological diseases .
|
-
- HY-116655A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Hydroxy-PEG1-acid sodium is a PEG linker containing a hydroxyl group with a terminal carboxylic acid (as sodium salt form). The free acid form is not stable due to the reaction of OH with PEG-COOH group to form polymer. The sodium salt form is stable for storage and shipping. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
|
-
- HY-128851R
-
|
|
Fatty Acid Synthase (FASN)
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
Coenzyme A (Standard) is the analytical standard of Coenzyme A. This product is intended for research and analytical applications. Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids[1].
|
-
- HY-W190958
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Boc-NH-Tri-(carbonylethoxymethyl)-methane is a branched PEG linker with a Boc-protected amino and three terminal carboxilic acid groups. The Boc group can be deprotected under mild acidic conditions to form the free amine. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W800654
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG5-amine is a PEG linker containing a maleimide group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
|
-
- HY-W190761
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Amino-PEG11-t-butyl ester is a click chemistry linker containing an amine and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
|
-
- HY-B0236A
-
|
EACA hydrochloride; Epsilon-Amino-n-caproic acid hydrochloride; 6-Aminohexanoic acid hydrochloride
|
Drug Derivative
PAI-1
|
Metabolic Disease
Cancer
|
|
6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .
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-
- HY-W190922
-
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Biochemical Assay Reagents
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Others
|
|
Mal-PEG4-amine is a PEG linker containing a maleimide group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
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-
- HY-W190955
-
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Biochemical Assay Reagents
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Others
|
|
N-(t-butyl ester-PEG3)-N-bis(PEG3-amine) is a PEG reagent that can easily react with activated NHS esters or carboxylic acid in the presence of EDC or HATU. The t-butyl group can be deprotected under acidic conditions. The hydrophilic PEG spacers increase the compounds water solubility in aqueous media.
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-
- HY-B0236
-
|
EACA; Epsilon-Amino-n-caproic acid; 6-Aminohexanoic acid
|
PAI-1
|
Metabolic Disease
Cancer
|
|
6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .
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-
- HY-W654232
-
|
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid-d4
|
Isotope-Labeled Compounds
Endogenous Metabolite
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Others
|
|
L-Hydroxyproline-d4 is deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals .
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-
- HY-100138
-
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|
Radionuclide-Drug Conjugates (RDCs)
ADC Linker
|
Cancer
|
|
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as 68Ga, 177Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine .
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-
- HY-157129
-
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|
AMPK
|
Cardiovascular Disease
|
|
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy .
|
-
- HY-136410
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
4-hydroxy Nonenal Mercapturic Acid (4-HNE) is generated by the peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid. 4-hydroxy Nonenal Mercapturic Acid is rapidly cleared from plasma and enters the enterohepatic circulation in rats as a glutathione conjugate. Approximately two-thirds of 4-hydroxy Nonenal Mercapturic Acid is excreted in the urine within 48 hours, primarily as mercapturic acid conjugates. Approximately half of the metabolites are C-1 aldehydes of 4-hydroxy Nonenal Mercapturic Acid that are reduced to alcohols. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form gamma-lactols and gamma-lactones, respectively, resulting in at least four or five final urinary metabolites of 4-HNE in vivo.
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-
- HY-W591402
-
|
|
ADC Linker
|
Cancer
|
|
3,4-Dibromo-Mal-PEG4-acid is a site specific ADC linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
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-
- HY-103332
-
|
NA-Gly
|
GlyT
Endogenous Metabolite
|
Inflammation/Immunology
|
|
N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .
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-
- HY-W101722
-
|
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl (9-aminononyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-W013151
-
|
|
Biochemical Assay Reagents
SARS-CoV
|
Others
|
|
1-Pyrenebutyric acid N-hydroxysuccinimide ester (PANHS) is a linker and interface coupling agent that can be used to prepare electrochemical biosensors. 1-Pyrenebutyric acid N-hydroxysuccinimide ester immobilizes SARS-CoV-2 spike antibodies on graphene sheets. 1-Pyrenebutyric acid N-hydroxysuccinimide ester is often used as an activation reagent for carboxylic acids in organic chemistry or biochemistry .
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-
- HY-W440807
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Oleoyl-Gly-Lys-(m-PEG11)-NH2 is a PEG-lipid molecule featuring an oleoyl amide linked to a Gly-Lys dipeptide and a methoxy PEG11 chain on the C-terminus of the lysine. The lysine primary amine may be used in a wide variety of reactions with carboxylic acids, NHS esters, and carbonyl groups. The PEG linker provides aqueous solubility.
|
-
- HY-B0024R
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Prulifloxacin (Standard) is the analytical standard of Prulifloxacin. This product is intended for research and analytical applications. Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a proagent of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis .
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-
- HY-W012885
-
|
|
Biochemical Assay Reagents
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Others
|
|
(S)-Methyl 3-hydroxybutanoate consists of a chiral center, resulting in two enantiomers, where (S)-Methyl 3-hydroxybutanoate means that the hydroxyl group is located on the third carbon atom of the S-configuration carboxylic acid group stereoisomers. This compound is often used as a building block for the synthesis of various pharmaceuticals and natural products. Due to its fruity taste, it is also used as a flavor and fragrance ingredient.
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-
- HY-W800649
-
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Biochemical Assay Reagents
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Others
|
|
Aminooxy-PEG2-amine hydrochloride (compound L3) is an aqueous soluble crosslinker. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond, if a reductant is used, it will form a hydroxylamine linkage. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term .
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-
- HY-Y1703
-
|
|
Biochemical Assay Reagents
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Others
|
|
HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU can be used along with Hünig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds .
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-
- HY-141147
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
7-O-(Amino-PEG4)-paclitaxel is a PEG-class Drug-linker conjugates for ADC, containing a paclitaxel moiety and a amino group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. 7-O-(Amino-PEG4)-paclitaxel can be used in the synthesis of Antibody-Drug Conjugates (ADCs) .
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-
- HY-167931
-
|
|
Drug Derivative
|
Metabolic Disease
|
|
Cinnamohydrazide, an unsaturated carboxylic acid derivative, serves as a precursor to aspartame through enzyme-mediated amination to phenylalanine. This compound may offer potential benefits in the prevention and treatment of diabetes by facilitating insulin secretion, enhancing pancreatic β-cell function, inhibiting hepatic gluconeogenesis, promoting glucose uptake, amplifying insulin signaling pathways, delaying carbohydrate digestion and glucose absorption, and reducing protein glycation and insulin fibrillation.
|
-
- HY-117219
-
|
|
Cytochrome P450
HMG-CoA Reductase (HMGCR)
Endogenous Metabolite
|
Metabolic Disease
|
|
SKF 104976 is a 3,2-carboxylic acid derivative with potent 14-alpha-demethylase (14 alpha DM) inhibitory activity. SKF 104976 inhibited 14 alpha DM activity by 50% at 2 nM in Hep G2 cell extracts. SKF 104976 inhibited the incorporation of [14C]acetate into cholesterol in intact cells at similar concentrations, accompanied by accumulation of lanosterol, and resulted in a 40-70% decrease in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity. SKF 104976 did not affect the uptake and degradation of low-density lipoprotein in Hep G2 cells, indicating that HMGR and low-density lipoprotein receptor activities are not coordinately regulated under these conditions. The inhibitory effect of SKF 104976 on HMGR activity remained unchanged even when the flux of carbon units in the sterol synthesis pathway was reduced by 80%. SKF 104976 did not inhibit HMGR activity under conditions where sterol synthesis was almost completely blocked by lovastatin .
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-
- HY-D2747
-
|
|
Fluorescent Dye
|
Others
|
|
BP Fluor 405 acid is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10.
The carboxylic acid of BP Fluor 405 is a reagent of choice for the preparation of custom activated esters that often are not commercially available. Examples of such activated esters include sulfo-NHS, TFP (2,3,5,6-Tetrafluorophenol), and STP (4-Sulfo-2,3,5,6-Tetrafluorophenol, Sodium Salt). Another common application for the non-activated carboxylic acid is peptide modification during solid phase synthesis, which usually requires in-situ activation with peptide coupling regents, e.g. HATU. BP Fluor 405 acid is also often used for control experiments, and for calibration.
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-
- HY-W800653
-
|
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Biochemical Assay Reagents
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Others
|
|
N-(Azido-PEG3)-NH-PEG3-t-butyl ester is a click chemistry reagent with a terminal azide group and secondary amine NH group. NH group is reactive with NHS ester, The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The azide group can participate in Click Chemistry.
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-
- HY-140533
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-(Azido-PEG2)-N-biotin-PEG3-acid is a PEG derivative which contains biotin and carboxylic acid moieties. N-(Azido-PEG2)-N-biotin-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups .
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-
- HY-W127801
-
|
EDTA trisodium hydrate
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Biochemical Assay Reagents
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Others
|
|
Ethylenediaminetetraacetic acid (trisodium hydrate) is a class of organic compounds containing carboxylic acid functional groups. It is commonly used as a chelating agent in various industrial and medical applications, especially in the food and pharmaceutical industries. Ethylenediaminetetraacetic acid (trisodium hydrate) has strong metal ion binding properties and can be used to chelate trace metals that may affect product quality or stability. In addition, it is used as an anticoagulant in blood collection tubes and as a stabilizer in some cosmetic and personal care products.
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-
- HY-140545
-
|
|
Fluorescent Dye
|
Others
|
|
N-(Azido-PEG2)-N-fluorescein-PEG4-acid is a fluorescein lableing reagent containing anazide group and a carboxylic acid. N-(Azido-PEG2)-N-fluorescein-PEG4-acid is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups .
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-
- HY-115545
-
|
|
ADC Linker
|
Cancer
|
|
DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC) . DBCO-NHS ester 3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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-
- HY-W127789
-
|
EDTA diammonium
|
Biochemical Assay Reagents
|
Others
|
|
Ethylenediaminetetraacetic acid diammonium is a class of organic compounds containing both ammonium and carboxylic acid functional groups. It is commonly used as a chelating agent in various industrial and medical applications, especially in the food and pharmaceutical industries. Ethylenediaminetetraacetic acid diammonium has strong metal ion binding properties and can be used to chelate trace metals that may affect product quality or stability. In addition, it is used as an anticoagulant in blood collection tubes and as a clarifying agent in cosmetic and personal care products.
|
-
- HY-117970
-
|
|
MMP
|
Cardiovascular Disease
|
|
MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively .
|
-
- HY-141148
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
7-O-(Cbz-N-amido-PEG4)-paclitaxel is a PEG-class Drug-linker conjugates for ADC, containing a paclitaxel moiety and a amino group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. 7-O-(Cbz-N-amido-PEG4)-paclitaxel can be used in the synthesis of Antibody-Drug Conjugates (ADCs) .
|
-
- HY-156939
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
ZnDTPA is an orally effective chelating agent, which belongs to the class of amino carboxylic acid chelating agents and is mainly used to form stable complexes with metal ions. DTPA (diethylenetriaminepentaacetic acid) itself is a polydentate ligand that can form stable cyclic or chain-like complexes with a variety of metal ions. ZnDTPA can be used to reduce the long-term toxicity of 239Pu to rats and reduce the incidence of osteosarcoma, breast cancer, etc. in rats .
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-
- HY-W005828
-
|
|
PROTAC Linkers
|
Cancer
|
|
9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. 9-(Boc-amino)nonanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-169358
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
L134 is a potent PROTAC BRD4 degrader with a DC50 value of 7.36 nM. L134 mediates the degradation of BRD4 via the ubiquitin-proteasome system in a DCAF11-dependent manner (Blue: JQ-1 (carboxylic acid) (HY-78695), Black: linker (HY-W004640); Pink: E3 ligase ligand, L321 (HY-169359)) .
|
-
- HY-W131541
-
|
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl (11-aminoundecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. tert-Butyl (11-aminoundecyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-W591967
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-Boc-15-aminopentadecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. N-Boc-15-aminopentadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-173308
-
|
|
Fluorescent Dye
|
Others
|
|
QSY-21 is a fluorescence quencher. QSY-21 possesses broad absorption in far red and NIR range, and can quench fluorescence of dyes that emit in this region. This is a carboxylic acid derivative. QSY-21 has intense absorption maximum at 661 nm, making it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications. It is a common quencher for Cyanine5, Cyanine5.5, AF 647, or other spectrally similar fluorescent dyes.
|
-
- HY-W089232
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-W101723
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-W012001
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-7-Aminoheptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-7-Aminoheptanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-103332S
-
|
NA-Gly-d8
|
Isotope-Labeled Compounds
Endogenous Metabolite
GlyT
|
Inflammation/Immunology
|
|
N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine . N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .
|
-
- HY-B0236S
-
|
EACA-d6; Epsilon-Amino-n-caproic acid-d6; 6-Aminohexanoic acid-d6
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
6-Aminocaproic acid-d6 is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .
|
-
- HY-W190905
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N4, N9-di-Boc-spermine is a spermine linker containing two a Boc-protected amino groups and two amine groups. The Boc groups can be deprotected under mild acidic conditions to form the free amine. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.
|
-
- HY-170808
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC BRD4 Degrader-28 (Compound 4) is a PROTAC degrader targeting BRD4. PROTAC BRD4 Degrader-28 is promising for research of cancers (Pink: target protein ligand JQ-1 (carboxylic acid) (HY-78695); Black+ Blue: E3 ubiquitin ligase ligand-Linker conjugate Thalidomide-O-amido-C3-NH2 (HY-115560)) .
|
-
- HY-W440955
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Stearic acid-PEG-CH2CO2H, MW 3400 is a lipophilic thiol-reactive PEG polymer. The stearic acid can be used to encapsulate hydrophobic therapeutic agents while the PEG chain increases overall water solubility and biocompatibilty. Reaction between carboxylic acid (-COOH) and amine (-NH2) vai condensation in the presence of activator, such as HATU or EDC, generates a stable amide linkage. Reagent grade, for research use only.
|
-
- HY-W800837
-
|
|
ADC Linker
|
Cancer
|
|
t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is cleavable by cell proteases and features a carboxylic acid which is free for coupling reactions with amines to form amides. The Boc can be removed under acidic conditions to reveal a free primary amine, which may be used in a variety of reactions such as coupling or reductive amination.
|
-
- HY-B0236R
-
|
EACA(Standard); Epsilon-Amino-n-caproic acid(Standard); 6-Aminohexanoic acid (Standard)
|
PAI-1
Reference Standards
Others
|
Metabolic Disease
Cancer
|
|
6-Aminocaproic acid (Standard) is the analytical standard of 6-Aminocaproic acid. This product is intended for research and analytical applications. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .
|
-
- HY-B0236S1
-
|
EACA-d10; Epsilon-Amino-n-caproic acid-d10; 6-Aminohexanoic acid-d10
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
6-Aminocaproic acid-d10 is the deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .
|
-
- HY-W348348
-
|
|
Biochemical Assay Reagents
|
Others
|
|
CbzNH-PEG3-CH2CH2NH2 is a PEG linker containing an amine group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
|
-
- HY-42773
-
|
1-Boc-1,8-diaminooctane
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl (8-aminooctyl)carbamate (1-Boc-1,8-diaminooctane) can be used as a PROTAC linker in the synthesis of PROTACs. tert-butyl (8-aminooctyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-W047688
-
|
1-Boc-1,10-diaminodecane
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl (10-aminodecyl)carbamate (1-Boc-1,10-diaminodecane) can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. tert-Butyl (10-aminodecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-119222
-
|
|
GPR109A
|
Metabolic Disease
|
|
GSK256073 is a potent, selective and orally active GPR109A agonist and a long-lasting and non-flushing HCA2 full agonist with a pEC50 of 7.5 (human HCA2). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis and has the potential for the study of type 2 diabetes mellitus (T2DM)and dyslipidemia . GPR109A: G-protein coupled receptor 109A; HCA2: hydroxy-carboxylic acid receptor 2
|
-
- HY-119222A
-
|
|
GPR109A
|
Metabolic Disease
|
|
GSK256073 tris is a potent, selective and orally active GPR109A agonist and a long-lasting and non-flushing HCA2 full agonist with a pEC50 of 7.5 (human HCA2). GSK256073 tris acutely improves glucose homeostasis via inhibition of lipolysis and has the potential for the study of type 2 diabetes mellitus (T2DM)and dyslipidemia . GPR109A: G-protein coupled receptor 109A; HCA2: hydroxy-carboxylic acid receptor 2
|
-
- HY-123824
-
|
|
Sodium Channel
|
Neurological Disease
|
|
GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders .
|
-
- HY-W041856
-
|
Boc-8-aminooctanoic acid
|
PROTAC Linkers
|
Cancer
|
|
N-Boc-8-amino-octanoic acid (Boc-8-aminooctanoic acid) can be used as a PROTAC linker in the synthesis of PROTACs. N-Boc-8-amino-octanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-78746A
-
|
|
Amino Acid Derivatives
|
Others
|
|
D-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-, (3S,4R,5S)-rel- is a proline derivative .
|
-
- HY-151820
-
|
|
ADC Linker
|
Others
|
|
DBCO-PEG24-acid is a click chemistry reagent. DBCO-PEG24-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
|
-
- HY-W800839
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TCO-PEG4-TFP Ester is an amine-reactive labeling reagent used to modify proteins, antibodies, and other amine-containing biopolymers. A 2,3,5,6-tetrafluorophenol (TFP) is a reactive ester that displays much better stability toward hydrolysis in aqueous media resulting in more efficiency and better reproducible labeling of biopolymers. TFP ester of carboxylic acids react with primary amines at the same rate as NHS ester forming covalent amide bond that is identical to one formed by the reaction between primary amines and NHS esters or sulfo-NHS esters.
|
-
- HY-D2751
-
|
|
Fluorescent Dye
|
Others
|
|
BP Fluor 488 Cadaverine is a carboxyl/carbonyl reactive building block used widely to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. BP Fluor 488 dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences.
|
-
- HY-W127409
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1,2-Dimyristoyl-rac-glycerol (C14:0) is a carboxylic acid ester, glycerolipid and diglyceride with an additional myristoyl group that facilitates interactions between proteins and lipids. Can be used as detergent or reagent. It plays a role in cell biology experiments involving the metabolism and metabolic pathways of glycerolipids. As a diglyceride, this substance consists of two fatty acid chains covalently bonded in the 1,2-form to a glycerol molecule. The diglyceride (DAG) study investigated the process by which DAG is depleted to inhibit fat accumulation. Reagent grade, for research use only.
|
-
- HY-23212A
-
|
|
Amino Acid Derivatives
|
Cancer
|
|
2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride is a non-protein amino acid, sulfamic acid.2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride contains one amino group and two terminal carboxylic acids.2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride has a variety of physiological functions, including maintaining the stability of cell membranes, regulating cholesterol metabolism, supporting the normal function of the nervous system, participating in collagen synthesis, and anti-oxidation .
|
-
- HY-130768
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker which contains azide, fluorescein and carboxylic acid moieties. N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-D1864
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-Cy7.5 dicarboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 dicarboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
|
-
- HY-145547
-
|
14:0 Lyso PE; 1-Myristoyl-2-hydroxy-sn-glycero-3-PE; 1-Tetradecanoyl-sn-glycero-3-phosphoethanolamine
|
Liposome
|
Metabolic Disease
|
|
1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells . Serum levels of 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine are elevated in patients with malignant breast cancer compared to healthy controls .
|
-
- HY-151821
-
|
|
ADC Linker
|
Others
|
|
Sulfo DBCO-PEG3-acid is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
|
-
- HY-Y0453S
-
|
Ethyl isonipecotate-d9; NSC 93792-d9; Piperidin-4-carboxylic acid ethyl ester-d9
|
Isotope-Labeled Compounds
|
Others
|
|
4-Carboethoxypiperidine-d9 is the deuterium labeled 4-Carboethoxypiperidine .
|
-
- HY-D2765
-
|
|
Biochemical Assay Reagents
|
Others
|
|
BP Fluor 405 Cadaverine is a carbonyl-reactive building block used to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. Another common application for BP Fluor 405 Cadaverine is cell fixing by treatment with formaldehyde or glutaraldehyde.
BP Fluor 405 is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode.
|
-
- HY-W061674
-
|
(E)-Pent-2-enoic acid
|
Biochemical Assay Reagents
|
Others
|
|
(2E)-Pent-2-enoic acid is an unsaturated carboxylic acid, it is also known as 2-pentenoic acid or crotonic acid, the "2E" designation indicates that the molecule has a trans double bond configuration, where the double bond The two carbon atoms on both sides are located on opposite sides, (2E)-Pent-2-enoic acid has a pungent odor, is miscible with water and most organic solvents, it is commonly used in organic synthesis as a variety of chemical reactions, including esterification, oxidation, and reduction, and in addition, its potential use as a flavoring agent in the food industry was investigated.
|
-
- HY-148840
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
|
-
- HY-148840A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Sulfo DBCO-PEG3-NHS ester TEA is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester (TEA) is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
|
-
- HY-W800617
-
|
|
ADC Linker
|
Cancer
|
|
NH2-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker intermediate featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
|
-
- HY-W800618
-
|
|
ADC Linker
|
Others
|
|
NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
|
-
- HY-W800619
-
|
|
ADC Linker
|
Others
|
|
NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
|
-
- HY-W800620
-
|
|
ADC Linker
|
Others
|
|
NH2-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
|
-
- HY-W010361
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Tetramethylammonium acetate is an organic compound commonly used as a phase transfer catalyst in organic synthesis reactions, especially those involving charged species or polar reagents. It can facilitate the transfer of reactants between two immiscible phases, such as water and organic solvents, by forming stable ion pairs. Additionally, Tetramethylammonium acetate has been used to prepare a variety of organic compounds, including esters, amides, and carboxylic acids. Due to its unique physicochemical properties, it has also been investigated for its potential use in developing new materials such as ionic liquids and liquid crystals. "x" in the formula represents the number of water molecules in the crystal structure, which can vary depending on the preparation method.
|
-
- HY-Y0319G
-
|
|
Endogenous Metabolite
AMPK
Reactive Oxygen Species
Caspase
Fungal
PPAR
|
Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Magnesium acetate tetrahydrate is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Magnesium acetate tetrahydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Magnesium acetate tetrahydrate regulates energy metabolism. Magnesium acetate tetrahydrate has anticancer activity against gastric cancer. Magnesium acetate tetrahydrate induces writhing reaction and ulcerative colitis. Magnesium acetate tetrahydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .
|
-
- HY-156438
-
|
|
NOD-like Receptor (NLR)
Interleukin Related
|
Neurological Disease
|
|
NT-0796 is an orally active, selective and CNS-penetrant NLRP3 inflammasome inhibitor. NT-0796 inhibits IL-1β release in human PBMC cells with an IC50 value of 0.32 nM. NT-0796 is an isopropyl ester that undergoes intracellular conversion to NDT-19795, the carboxylic acid active species. NT-0796 reverses high fat diet-induced obesity, systemic inflammation and astrogliosis in the diet-induced obesity mouse model. NT-0796 is promising for research of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis .
|
-
- HY-146295
-
|
|
COX
|
Inflammation/Immunology
|
|
COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 5.40, 0.01 and 1.78 μM, respectively .
|
-
- HY-170900
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
SJ44236 is the PROTAC degrader for BET that degrades BRD2 (DC50 = 0.127 nM), BRD3 and BRD4. SJ44236 exhibits cytotoxicity in cell MV4-11 and HD-MB03 with IC50s of 0.12 nM and 0.92 nM. SJ44236 downregulates the expression of c-Myc, upregulates the expression of p53. SJ44236 exhibits a good orally bioavailability of 45% in mice . (Pink: ligand for target protein JQ-1 carboxylic acid (HY-78695); Black: linker (HY-W012935); Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 54 (HY-W890189))
|
-
- HY-168936
-
|
|
PROTACs
Epigenetic Reader Domain
Apoptosis
|
Cancer
|
|
DP-15 is the degrader for GSPT1 and BRD4 with DC50s of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models . (Pink: ligand for target protein JQ-1 carboxylic acid (HY-78695); Black: linker (HY-W262798); Blue: ligand for E3 ligase Cereblon Thalidomide-5-OH (HY-23095))
|
-
- HY-146294
-
|
|
COX
|
Inflammation/Immunology
|
|
COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 12.13, 0.4 and 4.96 μM, respectively .
|
-
- HY-D2772
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. It also can be reversibly coupled to aldehydes and ketones to form a Schiff base – which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3).
Although the mixed isomers of 5(6)-TAMRA cadaverine is a preferred, routinely used orange-fluorescent dye for staining proteins, it is rearly used for labeling peptides and nucleotides. Purification of 5(6)-TAMRA labeled peptide and nucleotides might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer TAMRA usually give better resolution in HPLC purification that is often required in the conjugation processes.
|
-
- HY-151833
-
|
|
ADC Linker
|
Others
|
|
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-169385
-
|
|
AUTOTACs
Androgen Receptor
|
Cancer
|
|
ATC-324 is an bivalent AR (Androgen Receptor) degrader based on the protein degradation technology platform AUTOphagy-TArgeting Chimera (AUTOTAC). ATC-324 induces the formation of AR/p62 complex, leading to autophagy-lysosomal degradation of AR. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa . ATC-324 is composed of target-binding ligand (TBL) Enzalutamide (HY-70002) and p62/SQSTM1 autophagy-targeting ligand (ATL) YT 6-2 analog-1 (HY-169386), connected by Boc-NH-PEG4-CH2CH2NH2 (HY-W008352). Among them, the active control of the target protein ligand is Enzalutamide carboxylic acid (HY-70002B), and the conjugate composed of the autophagy-targeting ligand and the linker is YT 6-2-PEG3-C2-NH2 (HY-169387).
|
-
- HY-W707416S
-
|
N-(2,6-Dimethylphenyl)-N-(2-methoxyacetyl)-DL-alanine-d3; N-(2-Methoxyacetyl)-N-(2,6-xylyl)-DL-alanine-d3; CGA 62826-d3; rac-Metalaxyl carboxylic acid-d3
|
Isotope-Labeled Compounds
|
Others
|
|
N-(2,6-Dimethylphenyl)-N-(2-(methoxy-d3)acetyl)alanine (N-(2,6-Dimethylphenyl)-N-(2-methoxyacetyl)-DL-alanine-d3) is deuterium labeled N-(2,6-Dimethylphenyl)-N-(2-methoxyacetyl)alanine .
|
-
-
-
HY-L0101V
-
|
|
2,244,487 compounds
|
|
FCH Group Screening Library Collection contains about 2,244,487 lead-like compounds for biological screening. This brand new collection comprises polar molecules with pharmacologically important groups such as free carboxylic and amino groups.
|
| Cat. No. |
Product Name |
Type |
-
- HY-D1319A
-
|
Cy5 acid bromide
|
Fluorescent Dyes/Probes
|
|
Cyanine5 carboxylic acid (bromide) is a fluorescent dye containing a non-activated carboxylic acid (Ex=646 nm, Em=662 nm). Cyanine5 carboxylic acid chloride is an non-reactive dye that can be used in control samples .
|
-
- HY-D1823
-
|
VF 647A carboxylic acid（free acid）
|
Dyes
|
|
Vari Fluor 647A Carboxylic acid (VF 647A Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
|
-
- HY-D1830
-
|
VF 680 carboxylic acid（free acid）
|
Dyes
|
|
Vari Fluor 680 Carboxylic acid (VF 680 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
|
-
- HY-D1825
-
|
VF 532 carboxylic acid（free acid）
|
Dyes
|
|
Vari Fluor 532 Carboxylic acid (VF 532 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
|
-
- HY-D1824
-
|
VF 488 carboxylic acid（free acid）
|
Dyes
|
|
Vari Fluor 488 Carboxylic acid (VF 488 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
|
-
- HY-D1826
-
|
VF 594 carboxylic acid（free acid）
|
Dyes
|
|
Vari Fluor 594 Carboxylic acid (VF 594 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
|
-
- HY-D1821
-
|
VF 750 carboxylic acid（free acid）
|
Dyes
|
|
Vari Fluor 750 Carboxylic acid (VF 750 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
|
-
- HY-D1828
-
|
VF 640 carboxylic acid（free acid）
|
Dyes
|
|
Vari Fluor 640 Carboxylic acid (VF 640 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
|
-
- HY-D1829
-
|
VF 568 carboxylic acid（free acid）
|
Dyes
|
|
Vari Fluor 568 Carboxylic acid (VF 568 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
|
-
- HY-D1827
-
|
VF 660 carboxylic acid（free acid）
|
Dyes
|
|
Vari Fluor 660 Carboxylic acid (VF 660 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
|
-
- HY-D1822
-
|
VF 555 carboxylic acid（free acid）
|
Dyes
|
|
Vari Fluor 555 Carboxylic acid (VF 555 Carboxylic acid) free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivatives are unactivated labeled fluorescent dyes for protein, antibody, and polysaccharide labeling that require carboxylic acid activation for use .
|
-
- HY-D2176
-
|
|
Fluorescent Dyes/Probes
|
|
AF 555 carboxylic acid is a derivative of the orange fluorescent dye AF 555. AF 555 carboxylic acid is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling. AF 555 exhibits average excitation wavelengths under green laser and red laser of 510 nm and 610 nm, respectively .
|
-
- HY-D1650
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 630/650 carboxylic acid is a bright far-red fluorophore based on a borondipyrromethene scaffold. BDP 630/650 carboxylic acid is a BDP linker containing carboxylic acid. BDP 630/650 carboxylic acid can react with primary amine groups to form a stable amide bond. (λex=630 nm, λem=650 nm) .
|
-
- HY-W585407
-
|
|
Dyes
|
|
BDP TMR carboxylic acid is a BDP TMR labeled carboxylic acid. BDP TMR carboxylic acid has the fluorophore BDP and can be used for oligonucleotide labeling and amino acid sequencing .
|
-
- HY-W039519
-
|
|
Fluorescent Dyes/Probes
|
|
7-Methoxycoumarin-3-carboxylic acid is a fluorescent dye with an excitation peak at 355 nm and an emission peak at 405 nm. 7-Methoxycoumarin-3-carboxylic acid can be used to label peptide .
|
-
- HY-D1374
-
-
- HY-D0115
-
|
|
Fluorescent Dyes/Probes
|
|
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. 7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is a blue fluorescent dye for labeling proteins and nucleic acids .
|
-
- HY-W269179
-
|
|
Fluorescent Dyes/Probes
|
|
4-Bromomethyl-6,7-dimethoxycoumarin is a fluorescent label for carboxylic acids in chromatographic detection .
|
-
- HY-W806655
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3.5 carboxylic acid is a fluorophore featuring a carboxylic acid. The carboxylic acid is readily attacked by amines to form a stable amide bond. Cy3.5 is a cyanine dye with excitation and emission maxima at 576 nm and 603 nm respectively.
|
-
- HY-D1656
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 581/591 carboxylic acid is a fluorescent dye (Ex=585 nm, Em=594 nm). BDP 581/591 carboxylic acid has a free carboxylic acid group, which can be catalyzed by a catalyst (such as EDC or HATU) to react with primary amines to form stable amide bonds. BDP 581/591 carboxylic acid is highly photostable and can be used for ROS detection.
|
-
- HY-D1623
-
|
|
Fluorescent Dyes/Probes
|
|
Cyanine3 carboxylic acid chloride is a non-toxic red fluorescent dye with good solubility in organic solvents. Cyanine3 carboxylic acid chloride can be used as a non-reactive fluorophore for experimental control and calibration. Cyanine3 carboxylic acid chloride can also be synthesized with targeted agents as fluorescent probes for rapid detection of agent reactions .
|
-
- HY-D1885
-
|
|
Fluorescent Dyes/Probes
|
|
Vari Fluor 647 Carboxylic acid free acid is a carboxylic acid derivative of Vari Fluor. Vari Fluor carboxylic acid derivative is an inactive labeled fluorescent dye, which can be used to label proteins, antibodies, polysaccharides. The use of Vari Fluor carboxylic acid derivatives requires carboxylic acid activation.
|
-
- HY-W585384
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 558/568 carboxylic acid is a BDP linker containing a carboxylic acid. The BDP 558/568 has similar excitation and emission wavelengths to Cy3. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-D0035
-
|
|
Fluorescent Dyes/Probes
|
|
MPAC-Br is a highly sensitive fluorescent derivatization reagent for carboxylic acids in HPLC .
|
-
- HY-D1169
-
|
|
Fluorescent Dyes/Probes
|
|
BDP R6G carboxylic acid is a borondipyrromethene dye (Excitation: 530 nM; Emission: 548 nM). BDP R6G carboxylic acid terminal carboxylic acid can react with primary amine groups in the presence of activators to form a stable amide bond, for subsequent labeling reactions like Steglich esterification .
|
-
- HY-D1305
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 488 carboxylic acid is a new fluorescent label based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 carboxylic acid is a carboxylic acid derivative of ATTO 488, which can be used to label proteins or antibodies.
|
-
- HY-D2162
-
|
|
Fluorescent Dyes/Probes
|
|
AF 594 carboxylic acid is a carboxyl derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (Ex=594 nm, Em=615 nm). AF 594 carboxylic acid can form stable covalent bonds through the reaction of carboxylic acid groups with molecules with amino groups .
|
-
- HY-D2154
-
|
|
Fluorescent Dyes/Probes
|
|
AF 430 carboxylic acid is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 carboxylic acid can form covalent bonds through a condensation reaction between carboxylic acid groups and molecules containing amino groups. To achieve specific coupling of dye labels and biomolecules .
|
-
- HY-D2250
-
|
|
Fluorescent Dyes/Probes
|
|
Disulfo-ICG carboxylic acid is a derivative of ICG dye. ICG (Indocyanine Green) is a NIR fluorescent dye .
|
-
- HY-D1317A
-
|
|
Fluorescent Dyes/Probes
|
|
Cyanine7.5 carboxylic is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid functional groups. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Cyanine7.5 carboxylic can be covalently bound to some biological molecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
|
-
- HY-D1881
-
-
- HY-D2160
-
|
|
Fluorescent Dyes/Probes
|
|
AF 647 carboxylic acid is a derivative of the far-infrared dye AF 647. AF 647 is often used as a replacement for Cy5 dye, with an excitation wavelength (λex) of 635 nm (conventional fluorescence detection)/620 nm (instantaneous detection). The maximum excitation wavelength is 647 nm and the maximum emission wavelength is 671 nm. AF 647 carboxylic acid has a carboxylic acid group and can be coupled to biomolecules with amino groups to achieve dye labeling .
|
-
- HY-D2493
-
|
Cy7 COOH
|
Fluorescent Dyes/Probes
|
|
Cyanine7 carboxylic acid (Cy7 COOH) is a derivative of Cy7 (HY-D0825) dye. Cyanine7 carboxylic acid contains carboxyl groups, which can condense ammonia to form covalent bonds .
|
-
- HY-D0068
-
|
7-Diethylaminocoumarin-3-carboxylic acid, SE
|
Fluorescent Dyes/Probes
|
|
DEAC, SE (7-Diethylaminocoumarin-3-carboxylic acid, SE) is an excellent blue fluorescent building block for labeling amine-containing biomolecules.
|
-
- HY-D2172
-
|
|
Fluorescent Dyes/Probes
|
|
AF488 carboxylic acid is a non-reactive AF 488 form. AF488 exhibits the λem and λex wavelength of 520 nm and 470 nm, respectively .
|
-
- HY-D1366A
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cyanine5.5 carboxylic acid potassium is a fluorescent dye with excitation/emission wavelengths at 673/707 nm. The introduction of the sulfite group enhances the hydrophilic properties of the compound. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC and HATU, to form stable amide bonds.
|
-
- HY-D2749
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Bis-(N,N'-carboxylic acid)-Cy5 is a free unactivated carboxylic acid. Its absorbance and emission spectra are identical with Cy5 fluorophore.
|
-
- HY-D1881A
-
-
- HY-D1866
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cy7.5 carboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate ion (sulfonate) functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 carboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
|
-
- HY-W088089
-
|
|
Fluorescent Dyes/Probes
|
|
ICG-carboxylic acid is near-infrared (NIR) fluorescent probe. ICG is a fluorescent dye used in medical diagnostics. ICG has absorption peaking at 800 nm and can absorb the near IR laser energy and release heat in the dyed tissue (Ex/Em = 785/810 nm) .
|
-
- HY-D1337
-
|
|
Fluorescent Dyes/Probes
|
|
Cyanine7 carboxylic acid chloride belongs to the cyanine dye series and is a common fluorescent marker for biomolecules that can interact with biomolecules. Cyanine dyes may also bind to double-helical DNA through intercalation and exhibit enhanced fluorescence upon binding.
|
-
- HY-D1326
-
|
|
Fluorescent Dyes/Probes
|
|
Cyanine3 carboxylic acid belongs to the cyanine dye series and is a common fluorescent marker for biomolecules that can interact with biomolecules. Cyanine dyes may also bind to double-helical DNA through intercalation and exhibit enhanced fluorescence upon binding.
|
-
- HY-D1367
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cyanine7 carboxylic acid is a highly hydrophilic and water-soluble near-infrared dye. It improves quantum yield in the near-infrared range and has a very high molar extinction coefficient.
|
-
- HY-D1853
-
|
|
Dyes
|
|
Sulfo-Cy5 carboxylic acid is a Cy5 derivative that can be used for chemical synthesis. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) .
|
-
- HY-W998662
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin 343 X carboxylic acid is a blue emitting fluorophore used as a laser dye. The fluorophore can serve as a FRET donor for FAM (fluorescein).
|
-
- HY-D2169
-
|
|
Fluorescent Dyes/Probes
|
|
AF 568 carboxylic acid is the non-reactive form of the orange fluorescent dye AF 568. AF 568 has an absorption wavelength of 590-720 nm (FRET) and an emission wavelength of 515-720 nm. AF 568 alkyne forms stable covalent bonds by reacting carboxylic acid groups with molecules bearing amino groups. Copper-catalyzed azide-alkyne cycloaddition (CuAAc) can occur with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups .
|
-
- HY-D1853A
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cy5 carboxylic acid TEA is a Cy5 derivative that can be used for chemical synthesis. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) .
|
-
- HY-D2755
-
|
|
Fluorescent Dyes/Probes
|
|
BP Light 650 carboxylic acid is an vibrant far-red fluorochrome with comparable or improved performance over other dyes, including BP Fluor 647 and Cy5 dye, for fluorescent applications. It is used to label antibodies and other proteins as molecular probes for cellular imaging and other fluorescence detection methods application.
|
-
- HY-D1366
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cyanine5.5 carboxylic acidCI Pigment violet 32 is a water-soluble, far-red emitting fluorophore. Due to its four sulfo groups, this dye has a negative charge at neutral pH and is very hydrophilic. As a cyanine dye, sulfo-Cyanine5.5 shows a very low dependence of fluorescence on pH and a very high extinction coefficient.
|
-
- HY-D1040
-
|
Cyanine 5.5 carboxylic acid
|
Fluorescent Dyes/Probes
|
|
Cy5.5-COOH (Cyanine 5.5 carboxylic acid) is a fluorescent dye that emits fluorescence at 710 nm upon excitation at 650 nm. Cy5.5-COOH possesses excellent spectral properties, including a narrow absorption spectrum, high sensitivity, and stability. Cy5.5-COOH can be used for bioimaging and disease diagnosis .
|
- HY-D1040A
-
|
Cyanine 5.5 carboxylic acid chloride
|
Fluorescent Dyes/Probes
|
|
Cy5.5-COOH (Cyanine 5.5 carboxylic acid) chloride is a fluorescent dye that emits fluorescence at 710 nm upon excitation at 650 nm. Cy5.5-COOH chloride possesses excellent spectral properties, including a narrow absorption spectrum, high sensitivity, and stability. Cy5.5-COOH chloride can be used for bioimaging and disease diagnosis .
|
- HY-W127715
-
|
|
Fluorescent Dyes/Probes
|
|
Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .
|
- HY-D0934
-
|
|
Fluorescent Dyes/Probes
|
|
(5)6-Carboxytetramethylrhodamine contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid; bright, orange-fluorescent dye produces conjugates with absorption/emission maxima of ~555/580 nm .
|
- HY-D1096
-
|
|
Dyes
|
|
Sulfo-Cy5 diacid potassium is a water-soluble, inactive Cy5 carboxylic acid.
|
- HY-D2754
-
|
|
Fluorescent Dyes/Probes
|
|
BP Light 550 acid is a vibrant orange-to-red fluorochrome with better performance t han other rhodamine derivatives, including BP Fluor 555, TRITC, and Cy3 dye for fluorescent applications. The high water solubility of BP Light Fluors means that a high dye-to-protein ratio can be attained without causing precipitation of the conjugates.
|
- HY-D1970
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 700 Cadaverin is a cadaverine derivative of ATTO 700 for reactions of carboxylic acids, aldehydes and ketones with maximum excitation/emission wavelengths: 700/716 nm.
|
- HY-D2070
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 680 cadaverin is a cadaverine derivative of ATTO 680, used for carboxylic acid, aldehyde and ketone reactions, maximum excitation/emission wavelength: 681/698 nm.
|
- HY-D2055
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 532 cadaverin is a cadaverine derivative of ATTO 532, used for carboxylic acid, aldehyde and ketone reactions, maximum excitation/emission wavelength: 532/552 nm.
|
- HY-D2039
-
|
|
Fluorescent Dyes/Probes
|
|
ATTO 550 cadaverin is a cadaverine derivative of ATTO 550, used for carboxylic acid, aldehyde and ketone reactions, maximum excitation/emission wavelength: 554/576 nm.
|
- HY-103684
-
|
Real Thiol-NH2
|
Fluorescent Dyes/Probes
|
|
RT-NH2 is a RealThiol prototype without the carboxylic acid groups. RT-NH2 is fairly hydrophobic and cannot distribute in the nucleus, which is a hallmark of protein binding for fluorescent probe.
|
- HY-133883
-
|
|
Fluorescent Dyes/Probes
|
|
Cyanine7.5 amine is a NIR fluorescent dye. Cyanine7.5 amine contains free amino group which can be used coupled with activated carboxylic acid derivatives.
|
- HY-132270
-
|
|
Fluorescent Dyes/Probes
|
|
FAM amine, 5-isomer is a fluorescein linker that undergoes enzymatic transamination. The addition of the amine group makes the compound more reactive with carboxylic acids, activated NHS ester and other carbonyl groups.
|
- HY-W998707
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA amine, 5-isomer hydrochloride is a rhodamine dye with excitation/emission maximum 553/575 nm. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
- HY-W585403
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 630/650 hydrazide hydrochloride is a BDP linker containing a carboxylic acid. The BDP 630/650 has similar excitation and emission wavelengths to Cy5. Hydrazide moieties react with aldehydes to form semi-permanent hydrazone bonds.
|
- HY-D1658
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 581/591 amine hydrochloride is a BODIPY dye linker. BDP 581/591 is a universal, photostable fluorophore. The addition of the amine group allows for the compound to react with carboxylic acids, activated NHS esters and other carbonyl groups .
|
- HY-172284
-
|
|
Fluorescent Dyes/Probes
|
|
6-TAMRA cadaverine has achieved prominence as a dye for oligonucleotide labeling and automated DNA sequencing applications. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.
|
- HY-D0036
-
|
4-Bromomethyl-7-methoxycoumarin
|
Fluorescent Dyes/Probes
|
|
Br-Mmc (4-Bromomethyl-7-methoxycoumarin) is often used as fluorescent label for the determination of compounds possessing a carboxylic group. Br-Mmc is used for the determination fatty acids by TLC or HPLC .
|
- HY-D2764
-
|
|
Fluorescent Dyes/Probes
|
|
Difluorocarboxyfluorescein cadaverine, 5-isomer is a carbonyl reactive building block used to modify carboxylic groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond.
|
- HY-W585390
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 581/591 hydrazide hydrochloride is a BDP linker containing a hydrazide. The BDP 581/591 is very photostable. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
- HY-W585383
-
|
|
Fluorescent Dyes/Probes
|
|
BDP TR hydrazide is a BDP TR linker with a hydrazide group. The BDP dye is popular for the microscopy and fluorescence polarization assays. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
- HY-D2747
-
|
|
Fluorescent Dyes/Probes
|
|
BP Fluor 405 acid is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10.
The carboxylic acid of BP Fluor 405 is a reagent of choice for the preparation of custom activated esters that often are not commercially available. Examples of such activated esters include sulfo-NHS, TFP (2,3,5,6-Tetrafluorophenol), and STP (4-Sulfo-2,3,5,6-Tetrafluorophenol, Sodium Salt). Another common application for the non-activated carboxylic acid is peptide modification during solid phase synthesis, which usually requires in-situ activation with peptide coupling regents, e.g. HATU. BP Fluor 405 acid is also often used for control experiments, and for calibration.
|
- HY-173308
-
|
|
Fluorescent Dyes/Probes
|
|
QSY-21 is a fluorescence quencher. QSY-21 possesses broad absorption in far red and NIR range, and can quench fluorescence of dyes that emit in this region. This is a carboxylic acid derivative. QSY-21 has intense absorption maximum at 661 nm, making it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications. It is a common quencher for Cyanine5, Cyanine5.5, AF 647, or other spectrally similar fluorescent dyes.
|
- HY-D2751
-
|
|
Fluorescent Dyes/Probes
|
|
BP Fluor 488 Cadaverine is a carboxyl/carbonyl reactive building block used widely to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. BP Fluor 488 dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences.
|
- HY-130768
-
|
|
Fluorescent Dyes/Probes
|
|
N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker which contains azide, fluorescein and carboxylic acid moieties. N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
- HY-D1864
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cy7.5 dicarboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 dicarboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
|
- HY-D2765
-
|
|
Fluorescent Dyes/Probes
|
|
BP Fluor 405 Cadaverine is a carbonyl-reactive building block used to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. Another common application for BP Fluor 405 Cadaverine is cell fixing by treatment with formaldehyde or glutaraldehyde.
BP Fluor 405 is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode.
|
- HY-D2772
-
|
|
Fluorescent Dyes/Probes
|
|
5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. It also can be reversibly coupled to aldehydes and ketones to form a Schiff base – which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3).
Although the mixed isomers of 5(6)-TAMRA cadaverine is a preferred, routinely used orange-fluorescent dye for staining proteins, it is rearly used for labeling peptides and nucleotides. Purification of 5(6)-TAMRA labeled peptide and nucleotides might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer TAMRA usually give better resolution in HPLC purification that is often required in the conjugation processes.
|
| Cat. No. |
Product Name |
Type |
-
- HY-W002328
-
|
|
Biochemical Assay Reagents
|
|
Pyrazole-3-carboxylic acid is an alternative anchoring group to carboxylic acid in phthalocyanine dyes. Pyrazole-3-carboxylic acid shows flexible coordination modes when coordinates with metal ions. Pyrazole-3-carboxylic acid can chelate to metal ions and form very stable complexes through its N and O atoms. Pyrazole-3-carboxylic acid can be used to synthesize derivatives that possess antibacterial, anti-inflammatory, ulcerogenic liability and antiproliferative activities .
|
-
- HY-W002518
-
|
|
Biochemical Assay Reagents
|
|
Indazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002066
-
|
|
Biochemical Assay Reagents
|
|
Pyridazine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W004855
-
|
|
Biochemical Assay Reagents
|
|
Quinoline-6-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002404
-
|
|
Biochemical Assay Reagents
|
|
Pyrimidine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W004615
-
|
|
Biochemical Assay Reagents
|
|
Thiophene-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007371
-
|
|
Biochemical Assay Reagents
|
|
Quinoline-8-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-W004615R
-
|
|
Biochemical Assay Reagents
|
|
Thiophene-3-carboxylic acid (Standard) is the analytical standard of Thiophene-3-carboxylic acid. This product is intended for research and analytical applications. Thiophene-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W488088
-
-
- HY-144001
-
|
|
Drug Delivery
|
|
DSPE-PEG-Carboxylic Acid is a phospholipid PEG conjugate. DSPE-PEG-Carboxylic Acid can be widely used in the delivery of targeted agents and genes .
|
-
- HY-W042027
-
|
8-Isoquinoline-methaneaminedihydrochloride
|
Biochemical Assay Reagents
|
|
Isothiazole-5-carboxylic acid (8-Isoquinoline-methaneaminedihydrochloride) is an organic compound with antibacterial, anticancer and anti-inflammatory properties. Isothiazole-5-carboxylic acid can be used to develop novel compounds to combat various diseases. Isothiazole-5-carboxylic acid exhibits a wide range of potential pharmacological activities and helps improve existing inhibitory schemes.
|
-
- HY-76835
-
|
|
Biochemical Assay Reagents
|
|
5-Chlorothiophene-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-33287
-
|
|
Biochemical Assay Reagents
|
|
2-Bromothiazole-5-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W011560
-
|
|
Biochemical Assay Reagents
|
|
3-Methylflavone-8-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-32739
-
|
|
Biochemical Assay Reagents
|
|
5-Methylpyrazine-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007695
-
|
4-Imidazolecarboxylic acid
|
Biochemical Assay Reagents
|
|
1H-Imidazole-4-carboxylic acid is an organic compound containing an imidazole ring and a carboxyl group. 1H-Imidazole-4-carboxylic acid stabilizes specific forms of metal ions through coordination, thus influencing the progress of chemical reactions. 1H-Imidazole-4-carboxylic acid plays an important role in the hydrolysis of phosphate esters catalyzed by lanthanide metals. 1H-Imidazole-4-carboxylic acid can be used to modify dendrimers, changing the surface properties and catalytic performance of materials .
|
-
- HY-Y0236
-
|
Naphthalene-1-carboxylic acid
|
Biochemical Assay Reagents
|
|
Naphthalene-1-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W015420
-
|
|
Biochemical Assay Reagents
|
|
1H-Indole-6-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002064
-
|
|
Biochemical Assay Reagents
|
|
1H-Benzimidazole-6-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007927R
-
|
|
Biochemical Assay Reagents
|
|
1-Methyl-1H-indazole-3-carboxylic acid (Standard) is the analytical standard of 1-Methyl-1H-indazole-3-carboxylic acid. This product is intended for research and analytical applications. 1-Methyl-1H-indazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002623
-
|
|
Biochemical Assay Reagents
|
|
2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-107870
-
|
|
Chelators
|
|
1,2,4-Triazole-3-carboxylic acid, 97% is a biochemical assay reagent.
|
-
- HY-W007586
-
|
|
Biochemical Assay Reagents
|
|
(S)-1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-40226
-
|
|
Gene Sequencing and Synthesis
|
|
4-Amino-1-Boc-piperidine-4-carboxylic acid serves as a key intermediate for constructing various bioactive compounds .
|
-
- HY-20302R
-
|
|
Biochemical Assay Reagents
|
|
(2S,3AS,7aS)-Octahydroindole-2-carboxylic acid (Standard) is the analytical standard of (2S,3AS,7aS)-Octahydroindole-2-carboxylic acid. This product is intended for research and analytical applications. (2S,3AS,7aS)-Octahydroindole-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-141892A
-
|
DSPE PEG(2000) carboxylic acid sodium
|
Drug Delivery
|
|
DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid that can be used in the preparation of drug delivery nanoparticles .
|
-
- HY-59302
-
|
|
Cell Assay Reagents
|
|
Indole-5-carboxylic acid, 98% is an oxytocin that interacts with serotonin receptors and gamma-aminobutyric acid (GABA) receptors. It has also been reported to interact with various enzymes such as cyclooxygenase-2 (COX-2) and 5-hydroxytryptamine (5-HT) receptors.
|
-
- HY-34603
-
|
|
Biochemical Assay Reagents
|
|
1-Methyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007927
-
|
|
Biochemical Assay Reagents
|
|
1-Methyl-1H-indazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007593
-
|
|
Biochemical Assay Reagents
|
|
5-Bromo-1H-indole-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-40014
-
|
1-Boc-Piperidine-3-carboxylic acid
|
Biochemical Assay Reagents
|
|
1-Boc-piperidine-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-Y0549
-
|
Diphenylmethane-α-carboxylic acid
|
Biochemical Assay Reagents
|
|
Diphenylacetic acid (Diphenylmethane-α-carboxylic Acid) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-W002155
-
|
|
Biochemical Assay Reagents
|
|
Tetrahydropyran-4-yl-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W004978
-
|
|
Biochemical Assay Reagents
|
|
1,5-Dimethyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W127704
-
|
|
Biochemical Assay Reagents
|
|
IR 754 Carboxylic Acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-20302
-
|
|
Biochemical Assay Reagents
|
|
(2S,3AS,7aS)-Octahydroindole-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-Y1754
-
|
TOAC
|
Biochemical Assay Reagents
|
|
2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid (TOAC) is a compound with the ability to probe conformational changes, folding processes and interactions of peptides and proteins. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid is often used in relevant biological research to gain a deeper understanding of the behavior and function of biomacromolecules. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid plays an important role in analyzing the interactions and dynamic responses of biological systems.
|
-
- HY-22365
-
|
|
Biochemical Assay Reagents
|
|
1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W016473
-
|
|
Biochemical Assay Reagents
|
|
Adamantane-carboxylic acid is a compound with inhibitory activity against microorganisms. Although its specific target has not been clearly defined, it can inhibit Gram-positive bacteria and some Gram-negative bacteria. It forms a 1-monoacylglycerol derivative through a direct reaction with glycidol, and exerts its antibacterial effect by mechanisms such as altering the permeability of the bacterial cell membrane. This compound can be used in the research of antibacterial agents in the food and cosmetic industries to reduce harmful microbial flora and extend the shelf life of products .
|
-
- HY-W005223
-
|
(R)-(+)-Tetrahydrofuran-2-carboxylic acid
|
Biochemical Assay Reagents
|
|
(R)-(+)-2-Tetrahydrofuroic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002540
-
|
|
Biochemical Assay Reagents
|
|
6-Aminopyridine-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W001937
-
|
|
Biochemical Assay Reagents
|
|
[1,1'-Biphenyl]-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-32778
-
|
|
Biochemical Assay Reagents
|
|
5-Bromopyridine-2-carboxylic acid methyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002765
-
|
|
Biochemical Assay Reagents
|
|
2-Oxo-1,2-dihydropyridine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002688
-
|
|
Biochemical Assay Reagents
|
|
2,6-Dichloro-5-fluoropyridine-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W441002
-
|
|
Drug Delivery
|
|
DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics .
|
-
- HY-W007437
-
|
Naphthalene-2-carboxylic acid
|
Biochemical Assay Reagents
|
|
2-Naphthoic acid is an organic compound commonly used as a raw material for dyes and the production of other chemicals. It can form dyes with other organic substances and is widely used in textile, printing and manufacturing fields. In addition, the compound is also used as a photosensitive material and a lubricant.
|
-
- HY-W002139
-
|
6-Methylpyridine-2-carboxylic acid
|
Biochemical Assay Reagents
|
|
6-Methylpicolinic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W001578
-
|
|
Cell Assay Reagents
|
|
1-Adamantaneacetic acid is an aliphatic carboxylic acid that can be used as an acylating agent, commonly found in chemical synthesis .
|
-
- HY-W011412
-
|
|
Biochemical Assay Reagents
|
|
TSTU is able to converse carboxylic acid to the corresponding N-hydroxysuccinimidyl (NHS) ester, and is utilized as coupling reagent in peptide chemistry .
|
- HY-161590
-
|
|
Biochemical Assay Reagents
|
|
AHD/BSA is the antigen-adjuvant conjugate of AHD (furan-2-carboxylic acid) and Bovine Serum Albumin (BSA). By conjugating the antigen with the protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or destroy the main epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
|
- HY-40013
-
|
1-Boc-Piperidine-4-carboxylic acid
|
Biochemical Assay Reagents
|
|
Boc-Inp-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W017195
-
|
Propan-2-yl benzoate
|
Biochemical Assay Reagents
|
|
Isopropyl benzoate is a class of esters consisting of a benzene ring and an isopropyl group attached to a carboxylic acid group. Isopropyl benzoate can be used as an inducer to biosynthesize phloroglucinol in E. coli .
|
- HY-I0422
-
|
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
|
Biochemical Assay Reagents
|
|
L-Porretine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W1048542
-
|
|
Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW1000) is a PEG product containing two Fmoc-protected amines and a carboxylic acid. Fmoc-NH-PEG-COOH (MW1000) is an important cross-linking agent with PEG chains .
|
- HY-W127549
-
|
cis-6-Octadecenoic acid
|
Drug Delivery
|
|
Petroselinic acid sodium is an organic compound belonging to the class of carboxylic acids. Petroselinic acid sodium has several applications in the cosmetic and personal care industries, especially as an emulsifier and conditioning agent in skin and hair care products. In addition, it has potential utility in inhibiting inflammation-related diseases and cancer.
|
- HY-128851B
-
|
|
Enzyme Substrates
|
|
Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .
|
- HY-128851A
-
|
|
Enzyme Substrates
|
|
Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .
|
- HY-W088501
-
|
|
Biochemical Assay Reagents
|
|
(E)-Pent-3-enoic acidIt is an unsaturated carboxylic acid. (E)-Pent-3-enoic acidAs a starting material for various chemical reactions including esterification, oxidation and reduction. (E)-Pent-3-enoic acidIt has potential use as a flavoring agent in the food industry.
|
- HY-W012885
-
|
|
Biochemical Assay Reagents
|
|
(S)-Methyl 3-hydroxybutanoate consists of a chiral center, resulting in two enantiomers, where (S)-Methyl 3-hydroxybutanoate means that the hydroxyl group is located on the third carbon atom of the S-configuration carboxylic acid group stereoisomers. This compound is often used as a building block for the synthesis of various pharmaceuticals and natural products. Due to its fruity taste, it is also used as a flavor and fragrance ingredient.
|
- HY-W127801
-
|
EDTA trisodium hydrate
|
Biochemical Assay Reagents
|
|
Ethylenediaminetetraacetic acid (trisodium hydrate) is a class of organic compounds containing carboxylic acid functional groups. It is commonly used as a chelating agent in various industrial and medical applications, especially in the food and pharmaceutical industries. Ethylenediaminetetraacetic acid (trisodium hydrate) has strong metal ion binding properties and can be used to chelate trace metals that may affect product quality or stability. In addition, it is used as an anticoagulant in blood collection tubes and as a stabilizer in some cosmetic and personal care products.
|
- HY-W127789
-
|
EDTA diammonium
|
Biochemical Assay Reagents
|
|
Ethylenediaminetetraacetic acid diammonium is a class of organic compounds containing both ammonium and carboxylic acid functional groups. It is commonly used as a chelating agent in various industrial and medical applications, especially in the food and pharmaceutical industries. Ethylenediaminetetraacetic acid diammonium has strong metal ion binding properties and can be used to chelate trace metals that may affect product quality or stability. In addition, it is used as an anticoagulant in blood collection tubes and as a clarifying agent in cosmetic and personal care products.
|
- HY-W440955
-
|
|
Drug Delivery
|
|
Stearic acid-PEG-CH2CO2H, MW 3400 is a lipophilic thiol-reactive PEG polymer. The stearic acid can be used to encapsulate hydrophobic therapeutic agents while the PEG chain increases overall water solubility and biocompatibilty. Reaction between carboxylic acid (-COOH) and amine (-NH2) vai condensation in the presence of activator, such as HATU or EDC, generates a stable amide linkage. Reagent grade, for research use only.
|
- HY-W127409
-
|
|
Drug Delivery
|
|
1,2-Dimyristoyl-rac-glycerol (C14:0) is a carboxylic acid ester, glycerolipid and diglyceride with an additional myristoyl group that facilitates interactions between proteins and lipids. Can be used as detergent or reagent. It plays a role in cell biology experiments involving the metabolism and metabolic pathways of glycerolipids. As a diglyceride, this substance consists of two fatty acid chains covalently bonded in the 1,2-form to a glycerol molecule. The diglyceride (DAG) study investigated the process by which DAG is depleted to inhibit fat accumulation. Reagent grade, for research use only.
|
- HY-W061674
-
|
(E)-Pent-2-enoic acid
|
Biochemical Assay Reagents
|
|
(2E)-Pent-2-enoic acid is an unsaturated carboxylic acid, it is also known as 2-pentenoic acid or crotonic acid, the "2E" designation indicates that the molecule has a trans double bond configuration, where the double bond The two carbon atoms on both sides are located on opposite sides, (2E)-Pent-2-enoic acid has a pungent odor, is miscible with water and most organic solvents, it is commonly used in organic synthesis as a variety of chemical reactions, including esterification, oxidation, and reduction, and in addition, its potential use as a flavoring agent in the food industry was investigated.
|
- HY-W010361
-
|
|
Biochemical Assay Reagents
|
|
Tetramethylammonium acetate is an organic compound commonly used as a phase transfer catalyst in organic synthesis reactions, especially those involving charged species or polar reagents. It can facilitate the transfer of reactants between two immiscible phases, such as water and organic solvents, by forming stable ion pairs. Additionally, Tetramethylammonium acetate has been used to prepare a variety of organic compounds, including esters, amides, and carboxylic acids. Due to its unique physicochemical properties, it has also been investigated for its potential use in developing new materials such as ionic liquids and liquid crystals. "x" in the formula represents the number of water molecules in the crystal structure, which can vary depending on the preparation method.
|
- HY-Y0319G
-
|
|
Buffer Reagents
|
|
Magnesium acetate tetrahydrate is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Magnesium acetate tetrahydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Magnesium acetate tetrahydrate regulates energy metabolism. Magnesium acetate tetrahydrate has anticancer activity against gastric cancer. Magnesium acetate tetrahydrate induces writhing reaction and ulcerative colitis. Magnesium acetate tetrahydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-60256
-
-
- HY-W061650
-
-
- HY-76962
-
-
- HY-W051093
-
-
- HY-W044620
-
-
- HY-W053705
-
-
- HY-77584
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)non-8-enoyl)-4-hydroxypyrrolidine-2-carboxylic acid is a proline derivative .
|
-
- HY-W008446
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid is a proline derivative .
|
-
- HY-P10563
-
|
BHV-1100
|
CD38
|
Cancer
|
|
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .
|
-
- HY-W013201
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-1-((S)-2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:1) is a proline derivative .
|
-
- HY-78746A
-
|
|
Amino Acid Derivatives
|
Others
|
|
D-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-, (3S,4R,5S)-rel- is a proline derivative .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-40161
-
-
-
- HY-W002011
-
-
-
- HY-I0096
-
-
-
- HY-79494
-
-
-
- HY-33037
-
-
-
- HY-W001963
-
-
-
- HY-40161R
-
-
-
- HY-W050044
-
-
-
- HY-W001963R
-
-
-
- HY-33037R
-
|
|
Alkaloids
Structural Classification
Microorganisms
Other Alkaloids
Marine natural products
Source classification
|
Fungal
|
|
Phenazine-1-carboxylic acid (Standard) is the analytical standard of Phenazine-1-carboxylic acid. This product is intended for research and analytical applications. Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation[1][2][3][4].
|
-
-
- HY-75308
-
-
-
- HY-30004
-
|
|
Structural Classification
Microorganisms
Classification of Application Fields
Ketones, Aldehydes, Acids
Source classification
Metabolic Disease
Endogenous metabolite
Disease Research Fields
|
Endogenous Metabolite
|
|
1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity. .
|
-
-
- HY-N2321
-
-
-
- HY-N6877
-
-
-
- HY-30004R
-
|
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
|
Endogenous Metabolite
|
|
1-Aminocyclopropane-1-carboxylic acid (Standard) is the analytical standard of 1-Aminocyclopropane-1-carboxylic acid. This product is intended for research and analytical applications. 1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity. .
|
-
-
- HY-W031757
-
-
-
- HY-W002304R
-
-
-
- HY-66047
-
-
-
- HY-W002304
-
-
-
- HY-N1635
-
-
-
- HY-N9192
-
-
-
- HY-N1905
-
-
-
- HY-N7692
-
-
-
- HY-N7693
-
-
-
- HY-N4226R
-
|
|
Structural Classification
Microorganisms
other families
Ketones, Aldehydes, Acids
Source classification
Plants
|
AP-1
|
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (Standard) is the analytical standard of 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid. This product is intended for research and analytical applications. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function[1].
|
-
-
- HY-75087
-
-
-
- HY-75087R
-
-
-
- HY-N4226
-
|
|
Structural Classification
Microorganisms
other families
Classification of Application Fields
Ketones, Aldehydes, Acids
Source classification
Plants
Disease Research Fields
Cancer
|
AP-1
|
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function .
|
-
-
- HY-N1272
-
-
-
- HY-N15039
-
-
-
- HY-Y0569
-
-
-
- HY-Y0569B
-
-
-
- HY-W012946
-
-
-
- HY-N12911
-
-
-
- HY-Y0569C
-
-
-
- HY-129503
-
-
-
- HY-Y0030
-
-
-
- HY-N0140
-
-
-
- HY-W012946R
-
-
-
- HY-41404
-
-
-
- HY-Y0569BR
-
-
-
- HY-Y0569CR
-
-
-
- HY-40135
-
-
-
- HY-115773
-
-
-
- HY-N0140R
-
-
-
- HY-Y1644
-
-
-
- HY-N0823
-
-
-
- HY-128851
-
-
-
- HY-N0823R
-
-
-
- HY-128851R
-
-
- HY-B0236
-
-
- HY-103332
-
-
- HY-B0236R
-
-
| Cat. No. |
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Source |
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* This product has been "discontinued".
Optimized version of product available:
|
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-70002BS
-
|
|
|
Enzalutamide carboxylic acid-d6 is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide .
|
-
-
- HY-30004S
-
|
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1-Aminocyclopropane-1-carboxylic acid-d4 is the deuterium labeled 1-Aminocyclopropane-1-carboxylic acid. Aminocyclopropane-1-carboxylic acid is an endogenous metabolite[1].
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-
-
- HY-131314S
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Ibuprofen carboxylic acid-d3 is the deuterium labeled Ibuprofen carboxylic acid .
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-
-
- HY-W002011S
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Quinoline-2-carboxylic acid-d6 is the deuterium labeled Quinoline-2-carboxylic acid (HY-W002011). Quinoline-2-carboxylic acid exhibits antidiabetic activity. Quinoline-2-carboxylic acid can be used as drug intermediate for synthesis of various active compounds .
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-
- HY-I0096S
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Indole-2-carboxylic acid- 13C is the 13C-labeled Indole-2-carboxylic acid. Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current .
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- HY-W016473S
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Adamantane-carboxylic Acid-d15 is the deuterium labeled Adamantane-1-carboxylic acid .
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- HY-W017763S
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Tetrahydrofuran-2-carboxylic acid-d7 is the deuterium labeled Tetrahydrofuran-2-carboxylic acid .
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-
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- HY-40161S
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Indole-3-carboxylic acid-d4 is deuterium labeled Indole-3-carboxylic acid. Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .
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- HY-157071S
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Seliciclib Carboxylic Acid-d7 is deuterium-labeled Seliciclib Carboxylic Acid .
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- HY-12765S1
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Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .
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- HY-124356AS
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Alcaftadine carboxylic acid-d3 (sodium) is deuterium labeled Alcaftadine carboxylic acid. Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01% .
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- HY-W011560S
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3-Methylflavone-8-carboxylic acid-d5 is the deuterium labeled 3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid .
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- HY-W000793S
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5-Methoxy-1H-indole-3-carboxylic acid-d3 is the deuterium labeled 5-methoxy-1H-indole-3-carboxylic acid .
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- HY-W051624S
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(Rac)-2-Aminothiazoline-4-carboxylic acid- 13C, 15N2 is the deuterium labeled (Rac)-2-Aminothiazoline-4-carboxylic acid .
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- HY-W654362
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(R)-2-Thioxothiazolidine-4-carboxylic acid- 13C3 is the 13C-labeled (R)-2-Thioxothiazolidine-4-carboxylic acid. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
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- HY-W077074S
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1-Ethyl-1H-pyrazole-5-carboxylic acid-d5 is the deuterium labeled 1-Ethyl-1H-pyrazole-5-carboxylic acid (HY-W077074).
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- HY-101329S
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Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid . Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells .
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- HY-17512S1
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Losartan-d3 Carboxylic Acid is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
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- HY-W168915S
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1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid-d3 is deuterium labeled 1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid.
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- HY-W722107
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Timonacic-d4 (1,3-Thiazolidine-4-carboxylic acid-d4) is deuterium labeled Timonacic. Timonacic (1,3-Thiazolidine-4-carboxylic acid) is a thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects, and it can be used to study acute illnesses and liver diseases, by inducing reversal, it is also used in research on certain cancer cases .
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- HY-W246043
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3-Pyridine-2,4,5,6-d4 -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-carboxylic acid, ethyl ester .
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- HY-141749AS
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Clopidogrel carboxylic acid-d4 is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d4 can be used to further explore the metabolic characteristics of Clopidogrel .
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- HY-141749S
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(Rac)-Clopidogrel carboxylic acid-d4 is the deuterium labeled (Rac)-Clopidogrel carboxylic acid .
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- HY-75087S
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(R)-Pyrrolidine-2-carboxylic acid-d3 is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.
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- HY-114553S
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1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid-d5 (5F-PB-223-Carboxyindolemetabolite-d5) is deuterium labeled 1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid .
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- HY-W285163S
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1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
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- HY-12765S
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Losartan-d4 (carboxylic acid) is the deuterium labeled Losartan (EXP-3174), which is an angiotensin II receptor antagonist.
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- HY-W144430S
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2-[3-(Trifluoromethyl)phenoxy]nicotinic acid-d3 (2-[3-(Trifluoromethyl)phenoxy]pyridine-3-carboxylic acid, 3-[(3-Carboxypyridin-2-yl)oxy]benzotrifluoride-d3) is deuterium labeled 2-[3-(Trifluoromethyl)phenoxy]nicotinic acid .
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- HY-Y0001S1
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Cyclopropane-1-carboxylic Acid-d1 is the deuterium labeled Cyclopropane-1-carboxylic Acid .
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- HY-33013S
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Clevidipine impurity 24- 13C,d3 is 13C and deuterium labeled 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid .
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- HY-W012946S
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2-Furoic acid-d3 is the deuterium labeled 2-Furoic acid . 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats .
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- HY-129503S
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2-Heptyl-4-quinolone- 13C6 is the 13C-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .
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- HY-129503S1
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2-Heptyl-4-quinolone- 15N is the 15N-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .
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- HY-W018728S
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3,5-Dimethylbenzoic acid-d9 is the deuterium labeled 3,5-Dimethylbenzoic acid .
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- HY-W654232
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L-Hydroxyproline-d4 is deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals .
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- HY-103332S
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N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine . N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .
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- HY-B0236S
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6-Aminocaproic acid-d6 is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .
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- HY-B0236S1
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6-Aminocaproic acid-d10 is the deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .
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- HY-Y0453S
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4-Carboethoxypiperidine-d9 is the deuterium labeled 4-Carboethoxypiperidine .
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- HY-W707416S
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N-(2,6-Dimethylphenyl)-N-(2-(methoxy-d3)acetyl)alanine (N-(2,6-Dimethylphenyl)-N-(2-methoxyacetyl)-DL-alanine-d3) is deuterium labeled N-(2,6-Dimethylphenyl)-N-(2-methoxyacetyl)alanine .
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| Cat. No. |
Product Name |
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Classification |
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- HY-115545
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DBCO
ADC Synthesis
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DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC) . DBCO-NHS ester 3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- HY-151820
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DBCO
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DBCO-PEG24-acid is a click chemistry reagent. DBCO-PEG24-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
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- HY-140533
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Azide
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N-(Azido-PEG2)-N-biotin-PEG3-acid is a PEG derivative which contains biotin and carboxylic acid moieties. N-(Azido-PEG2)-N-biotin-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups .
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- HY-130768
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PROTAC Synthesis
Azide
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N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker which contains azide, fluorescein and carboxylic acid moieties. N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-151821
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DBCO
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Sulfo DBCO-PEG3-acid is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
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- HY-148840
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DBCO
|
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Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .
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- HY-151833
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Tetrazine
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Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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| Cat. No. |
Product Name |
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Classification |
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- HY-141892A
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DSPE PEG(2000) carboxylic acid sodium
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Pegylated Lipids
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DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid that can be used in the preparation of drug delivery nanoparticles .
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- HY-W441002
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Phospholipids
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DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics .
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- HY-W800793
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1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl)
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Phospholipids
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16:0 Succinyl PE is a carboxylic acid-functionalized lipid with a two carbon linker to a phosphoethanolamine bound to two palmitic acid tails.
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- HY-144001
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Pegylated Lipids
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DSPE-PEG-Carboxylic Acid is a phospholipid PEG conjugate. DSPE-PEG-Carboxylic Acid can be widely used in the delivery of targeted agents and genes .
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-
- HY-154085
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Nucleosides and their Analogs
U
|
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(2’,3’,5’-Tri-O-acetyl)uridine 5-carboxylic acid is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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- HY-W440820
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Cationic Lipids
|
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Bis(bis(2-carboxyethyl)aminopropyl)methylamine is a symmetrical branched linker featuring three tertiary amines and four carboxylic acids. Each carboxylic acid is open to forming esters or amides. It can be used in developing lipid nanoparticles.
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-
- HY-W800794
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DPPE-NG; 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(glutaryl)
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Phospholipids
|
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16:0 Glutaryl PE is is a carboxylic acid-functionalized lipid with a three carbon linker to a phosphoethanolamine bound to two palmitic acid tails.
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-
- HY-W800792
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1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl)
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Phospholipids
|
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18:1 Succinyl PE is a carboxylic acid-functionalized lipid with a two carbon linker to a phosphoethanolamine bound to two oleic acid tails.
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-
- HY-W800795
-
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DOPE-NG; 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(dodecanoyl)
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Phospholipids
|
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18:1 Dodecanyl PE is a carboxylic acid-functionalized lipid with a ten carbon linker to a phosphoethanolamine bound to two oleic acid tails.
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-
- HY-W441005
-
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Phospholipids
|
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Amino-Gly-Gly-DSPE (hydrochloride) is a specially modified phospholipid that has been used to synthesize liposomes. The terminal amine is reactive with an NHS ester compound or carboxylic acid molecule in the presence of activator, such as HATU or EDC.
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-
- HY-W591461
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|
Pegylated Lipids
|
|
DSPE-PEG-COOH, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.
|
-
- HY-115435
-
|
DMPS-Na; Dimyristoyl phosphatidylserine sodium
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Phospholipids
|
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1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine sodium is an anionic phospholipid with myristic acid tails (14:0) and contains a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of liposome.
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-
- HY-W800825
-
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|
|
Cationic Lipids
|
|
Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
|
-
- HY-W440986
-
|
DSPS sodium
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|
Phospholipids
|
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Distearoylphosphatidylserine sodium is an anionic phospholipid with stearic acid tails (18:0) and contains a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of lipid-mixing vesicles, liposome, or artificial membrane. Due to the medium size of fatty acid chain, DLPS is used to form thinner membranes/walls.
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-
- HY-W440985
-
|
1,2-dilauroyl-sn-glycero-3-phospho-L-serine
|
|
Phospholipids
|
|
DLPS is an anionic phospholipid with lauric acid tails (12:0) and contains a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of lipid-mixing vesicles, liposome, or artificial membrane. Due to the medium size of fatty acid chain, DLPS is used to form thinner membranes/walls.
|
-
- HY-W714524
-
|
1,2-POPS; 1,2-POPS; 2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine sodium; 1-Hexadecanoyl-2--(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine sodium salt
|
|
Phospholipids
|
|
2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine sodium is an anionic phospholipid with oleic acid (18:1) and palmitic acid (16:0) tails containing a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of lipid-mixing vesicles, liposomes, and artificial membranes.
|
-
- HY-145547
-
|
14:0 Lyso PE; 1-Myristoyl-2-hydroxy-sn-glycero-3-PE; 1-Tetradecanoyl-sn-glycero-3-phosphoethanolamine
|
|
Phospholipids
|
|
1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells . Serum levels of 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine are elevated in patients with malignant breast cancer compared to healthy controls .
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