Pyrimidine-4-carboxylic acid

Name: Pyrimidine-4-carboxylic acid
Brand: MedChemExpress
SKU: HY-W002404
Rating: 4.5 (1 reviews)

Cat. No.: HY-W002404 Purity: 99.53%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Pyrimidine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

Pyrimidine-4-carboxylic acid Chemical Structure

CAS No. : 31462-59-6

Size	Stock	Quantity
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
Customer Review

Description

Pyrimidine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

In Vitro

Pyrimidine-4-carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

124.10

Formula

C₅H₄N₂O₂

CAS No.

31462-59-6

Appearance

Solid

Color

Off-white to gray

SMILES

OC(C1=NC=NC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (805.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.0580 mL	40.2901 mL	80.5802 mL
5 mM	1.6116 mL	8.0580 mL	16.1160 mL
10 mM	0.8058 mL	4.0290 mL	8.0580 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (40.29 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (40.29 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.53%

Select Batch:

Data Sheet (246 KB) SDS (393 KB)

COA (249 KB) HNMR (137 KB) RP-HPLC (229 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.0580 mL	40.2901 mL	80.5802 mL	201.4504 mL
	5 mM	1.6116 mL	8.0580 mL	16.1160 mL	40.2901 mL
	10 mM	0.8058 mL	4.0290 mL	8.0580 mL	20.1450 mL
	15 mM	0.5372 mL	2.6860 mL	5.3720 mL	13.4300 mL
	20 mM	0.4029 mL	2.0145 mL	4.0290 mL	10.0725 mL
	25 mM	0.3223 mL	1.6116 mL	3.2232 mL	8.0580 mL
	30 mM	0.2686 mL	1.3430 mL	2.6860 mL	6.7150 mL
	40 mM	0.2015 mL	1.0073 mL	2.0145 mL	5.0363 mL
	50 mM	0.1612 mL	0.8058 mL	1.6116 mL	4.0290 mL
	60 mM	0.1343 mL	0.6715 mL	1.3430 mL	3.3575 mL
	80 mM	0.1007 mL	0.5036 mL	1.0073 mL	2.5181 mL
	100 mM	0.0806 mL	0.4029 mL	0.8058 mL	2.0145 mL