Search Result

Results for "

JUN

" in MedChemExpress (MCE) Product Catalog:

By Targets:	JNK (30) Akt (1) Amyloid-β (1) AP-1 (5) Apoptosis (12) Aurora Kinase (1) Autophagy (2) Biochemical Assay Reagents (2) c-Myc (1) Caspase (1) COX (1) Dipeptidyl Peptidase (1) Enterovirus (4) ERK (2) Eukaryotic Initiation Factor (eIF) (1) FGFR (1) FLT3 (1) Fluorescent Dye (1) GSK-3 (1) iGluR (1) Isotope-Labeled Compounds (2) MAP3K (2) MAP4K (1) MEK (1) Microtubule/Tubulin (2) Mixed Lineage Kinase (1) MMP (2) p38 MAPK (3) PAK (1) Parasite (3) Phosphatase (2) PKC (4) PPAR (1) Pyruvate Kinase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) SARS-CoV (5) Small Interfering RNA (siRNA) (6) STK33 (1) Trk Receptor (1) VEGFR (1) Virus Protease (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (7) Infection (11) Inflammation/Immunology (14) Metabolic Disease (1) Neurological Disease (15)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: JNK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118529

JUN-1111	Phosphatase	Cancer
JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC₅₀ values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1 .

HY-157403

Jun12682	SARS-CoV	Infection
Jun12682 is an inhibitor of SARS-CoV-2 papain-like protease. Jun12682 inhibits PL ^pro with a K_i value of 37.7 nM. Jun12682 has EC₅₀ value of 1.1 μM in the FlipGFP PL ^pro assay. Jun12682 has orally activity .

HY-158751

Jun9-72-2	SARS-CoV	Infection
Jun9-72-2 is a papain (Plpro) inhibitor of SARS-CoV-2 with an IC₅₀ value of 0.67 μM. Jun9-72-2 has antiviral activity .

HY-175165

Jun6504	Enterovirus	Infection
Jun6504 is an enterovirus 2C inhibitor. Jun6504 shows potent and broad-spectrum antiviral activity against multiple strains of EV-D68 (EC₅₀ = 250 nM), EV-A71 (EC₅₀ = 502.4 nM), and CVB3 (EC₅₀ = 1049 nM). Jun6504 improves paralysis score and weight gain in a neonatal mouse model of EV-D68 infection. Jun6504 reduces viral titers in the spinal cord and the infected quadriceps muscle. Jun6504 can be used for EV-D68 antiviral research .

HY-159985

Jun13728	SARS-CoV	Infection
Jun13728 is a potent and covalent SARS-CoV-2 papain-like protease inhibitor, with an IC₅₀ of 0.1 μM. Jun13728 can be used for SARS-CoV-2 antiviral research .

HY-157305

Jun11165	SARS-CoV	Infection
Jun11165 is a SARS-CoV-2 PL ^pro inhibitor (IC₅₀ ≤ 0.6 μM), which inhibits SARS-CoV-2 with an EC₅₀ value of ≤ 6 μM. Jun11165 can be used in the research of viral infections .

HY-168916

Jun13296	SARS-CoV Virus Protease
Jun13296 is an orally active quinoline SARS-CoV-2 papain-like protease inhibitor (IC₅₀ = 0.13 µM, K_i = 8.8 nM). Jun13296 exhibits potent inhibition against SARS-CoV-2 variants and Nirmatrelvir (HY-138687)-resistant mutants. Jun13296 improves lung viral titers, and prevents lung tissue damage in a SARS-CoV-2 infection model .

HY-D2898

Jun14157	Fluorescent Dye Enterovirus	Infection
Jun14157 is a fluorescence polarization probe that can specifically bind to the conserved allosteric site of enterovirus 2C proteins (Ex: 485/20; Em: 528/20). Jun14157 has K_d values of 2.3 μM, 1.4 μM, and 1.1 μM for EV-D68 2C, EV-A71 2C, and CVB3 2C, respectively. Jun14157 can be used in research related to enteroviruses .

HY-174814

Jun15716	Enterovirus	Infection
Jun15716 is an Enterovirus (EVs) 2C protein (EVs 2C) inhibitor with K_is of 15.9, 44.2 and 17.8 μM for EV-D68, EV-A71 and CVB3, respectively. Jun15716 has a potent antiviral activity against EV-D68 US/MO/14-18947 and CVB3 Nancy cells (EC₅₀s of 1.0 and 0.7 μM, respectively). Jun15716 can be used for viral infections research, such as meningitis, hand, foot and mouth disease (HFMD) and viral myocarditis .

HY-174815

Jun15799	Enterovirus	Infection
Jun15799 is an Enterovirus (EVs) 2C protein (EVs 2C) inhibitor with K_is of 0.8, 21.1 and 3.0 μM for EV-D68, EV-A71 and CVB3, respectively. Jun15799 has a significant antiviral activity against EV-D68 US/MO/14-18947, EV-A71 Tainan/4643/1998 and CVB3 Nancy cells (EC₅₀s of 0.3, 11.4 and 0.3 μM, respectively). Jun15799 can be used for viral infections research, such as meningitis, hand, foot and mouth disease (HFMD) and viral myocarditis .

HY-RS07056

Jun Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Jun Rat Pre-designed siRNA Set A contains three designed siRNAs for Jun gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Jun Rat Pre-designed siRNA Set A Jun Rat Pre-designed siRNA Set A

HY-RS07055

Jun Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Jun Mouse Pre-designed siRNA Set A contains three designed siRNAs for Jun gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Jun Mouse Pre-designed siRNA Set A Jun Mouse Pre-designed siRNA Set A

HY-RS07054

JUN Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
JUN Human Pre-designed siRNA Set A contains three designed siRNAs for JUN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

JUN Human Pre-designed siRNA Set A JUN Human Pre-designed siRNA Set A

HY-171204

*In vivo Jun* Mouse Pre-designed siRNA-3**	Small Interfering RNA (siRNA)	Cancer
In vivo Jun Mouse Pre-designed siRNA-3 is a siRNA product designed for the Jun (Mouse) gene and can be used for in vivo experiments in mice.

HY-171202

*In vivo Jun* Mouse Pre-designed siRNA-1**	Small Interfering RNA (siRNA)	Cancer
In vivo Jun Mouse Pre-designed siRNA-1 is a siRNA product designed for the Jun (Mouse) gene and can be used for in vivo experiments in mice.

HY-171203

*In vivo Jun* Mouse Pre-designed siRNA-2**	Small Interfering RNA (siRNA)	Cancer
In vivo Jun Mouse Pre-designed siRNA-2 is a siRNA product designed for the Jun (Mouse) gene and can be used for in vivo experiments in mice.

HY-P1190

*c-JUN* peptide**	JNK Apoptosis	Inflammation/Immunology
c-JUN peptide is a cell-permeable c-JUN-JNK interaction inhibitor. c-JUN peptide inhibits serum-induced c-Jun phosphorylation. c-JUN peptide induces apoptosis .

HY-P4699

*(Thr17)-c-Jun* (11-23)**	JNK	Others
(Thr17)-c-Jun (11-23) is a fragment peptide of c-Jun.

HY-107599

AEG3482	JNK Apoptosis	Neurological Disease
AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25 .

HY-P10506

CMX-8933	JNK	Neurological Disease
CMX-8933 is an octapeptide fragment of the goldfish brain neurotrophic factor ependymin. CMX-8933 increases the enzymatic activity of c-Jun N-terminal kinase (JNK), increases the phosphorylation of JNK and c-Jun proteins, and increases the cellular levels of c-Jun and c-Fos mRNA. CMX-8933 can be used to study the role of ependymin in neuroplasticity, learning, memory formation, and neural regeneration .

HY-P10048

TAT-JIP	JNK	Inflammation/Immunology
TAT-JIP inhibits the phosphorylation of endogenous c-jun activated by PHA–PMA .

HY-134975

NY2267	c-Myc	Cancer
NY2267 is a disruptor of Myc-Max interaction, with an IC₅₀ of 36.5 μM. NY2267 inhibits Myc- and Jun-induced transcriptional activation .

HY-169314

JNK-IN-19	JNK	Cardiovascular Disease Inflammation/Immunology
JNK-IN-19 (Compound Q8) is a *c-Jun* N-terminal kinase** inhibitor that is used for treating and/or preventing an injury before, during, or after a surgical procedure .

HY-N1961

Ophiopogonin B OP-B	JNK Apoptosis	Cancer
Ophiopogonin B (OP-B) induces the autophagy and apoptosis of colon cancer cells by activating *JNK/c-Jun* signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus .

HY-107621

U0124	MEK	Cancer
U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM .

HY-107598

JNK Inhibitor VIII 3 Publications Verification TCS JNK 6o	JNK	Cancer
JNK Inhibitor VIII (TCS JNK 6o) is a *c-Jun* N-terminal kinases (JNK-1, -2, and -3) inhibitor with K_i values of 2 nM, 4 nM, 52 nM, respectively, and has IC₅₀** values of 45 nM and 160 nM for JNK-1 and -2, respectively .

HY-107600

IQ-3 2 Publications Verification	JNK	Inflammation/Immunology
IQ-3 is a specific inhibitor of the *c-Jun* N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits K_d** values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively .

HY-168895

c-Fos-IN-1	AP-1 ERK Apoptosis	Cancer
c-Fos-IN-1 (Compound P16) is a *c-Jun* inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC₅₀: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth .

HY-B1198

Piperonyl butoxide 1 Publications Verification ENT-14250	Parasite	Infection Cancer
Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate *c-Jun* and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .

HY-P6177

SGP8	Dipeptidyl Peptidase	Inflammation/Immunology
SGP8 (IAVPGEVA) is an octapeptide produced by hydrolysis of soybean 11S globulin, which has the effects of regulating lipid metabolism, inflammation and fibrosis. SGP8 (IAVPGEVA) exhibits inhibitory activity against DPP4 and inhibits the *JNK-c-Jun* signaling pathway, and has the ability to inhibit non-alcoholic steatohepatitis (NASH) .

HY-138304

CC-90001 1 Publications Verification	JNK	Inflammation/Immunology
CC-90001 is a potent, selective and orally active inhibitor of *c-Jun* N-terminal kinase (JNK). CC-90001 shows 12.9-fold selectivity for JNK1 over JNK2** in a cell-based model. CC-90001 can be used for the research of idiopathic pulmonary fibrosis .

HY-114250

Cantrixil TRX-E-002-1	Apoptosis	Cancer
Cantrixil (TRX-E-002-1), an active enantiomer of TRX-E-002, is a second-generation super-benzopyran (SBP) compound. Cantrixil increases phosphorylated *c-Jun* levels resulting in caspase-mediated apoptosis in ovarian cancer cells. Cantrixil has potent pan anti-cancer activity against a broad range of cancer phenotypes .

HY-125838

J30-8	JNK	Neurological Disease
J30-8 is a potent and isoform-selective inhibitor of *c-Jun* N-terminal kinase 3 (JNK3) with an IC₅₀** of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases .

HY-176213

JNK2/3-IN-1	JNK	Neurological Disease
JNK2/3-IN-1 (Compound 56d) is an irreversible covalent inhibitor of c-Jun N-terminal kinases 2/3 (JNK2/3) with IC₅₀ values of 830 and 1909 nM, respectively. JNK2/3-IN-1 is promising for research of neurodegenerative diseases (e.g., Parkinson’s, Alzheimer’s) and fibrotic disorders .

HY-148510

HKB99	Phosphatase Apoptosis Akt ERK Reactive Oxygen Species (ROS)	Cancer
HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 induces apoptosis. HKB99 inhibits the formation of invasive pseudopodia and inhibits migration. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and ERK. HKB99 can be used for the research of non-small-cell lung cancer (NSCLC) .

HY-B1198S

Piperonyl butoxide-d9 ENT-14250-d₉	Isotope-Labeled Compounds Parasite	Infection Cancer
Piperonyl butoxide-d₉ is the deuterium labeled Piperonyl butoxide.Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate *c-Jun* and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .

HY-13241

Ralimetinib dimesylate 10+ Cited Publications LY2228820 dimesylate	p38 MAPK Autophagy Apoptosis	Inflammation/Immunology Cancer
Ralimetinib dimesylate (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC₅₀s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38a MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc.

HY-13241A

Ralimetinib LY2228820	p38 MAPK Autophagy	Inflammation/Immunology Cancer
Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC₅₀s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc .

HY-B1198R

Piperonyl butoxide (Standard) ENT-14250 (Standard)	Parasite Reference Standards	Infection Cancer
Piperonyl butoxide (Standard) is the analytical standard of Piperonyl butoxide. This product is intended for research and analytical applications. Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate *c-Jun* and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .

HY-114331

DLK-IN-1	MAP3K FLT3 PAK STK33 Trk Receptor	Neurological Disease
DLK-IN-1 (Compound 14) is an orally active, blood-brain barrier-penetrable and selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with a K_i value of 3 nM. DLK-IN-1 inhibits Flt3, PAK4, STK33 and TrkA. DLK-IN-1 reduces *p-c-Jun*. DLK-IN-1 can be used in Alzheimer's disease research .

HY-W010983

SC-236 1 Publications Verification	COX PPAR Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
SC-236 is an orally active COX-2 specific inhibitor (IC₅₀ = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model .

HY-152142

DN-1289	JNK	Neurological Disease
DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK; IC₅₀=17 nM) and leucine zipper-bearing kinase (LZK; IC₅₀=40 nM). DN-1289 results significant attenuation of optic nerve crush (ONC)-induced p-c-Jun in mice model. DN-1289 has excellent in vivo plasma half-life and blood-brain barrier permeability .

HY-12270

T-5224 Maximum Cited Publications 79 Publications Verification	AP-1 MMP	Others
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-P10401

TAT-GluR6-9c	Apoptosis iGluR	Cardiovascular Disease Neurological Disease
TAT-GluR6-9c is a GluR6-PSD95 interaction blocker. By regulating the GluR6 mediated signaling pathway, TAT-GluR6-9c inhibits the activation of JNK and phosphorylation of c-Jun, reduces the expression of Fas L and thus reduces the occurrence of apoptosis. TAT-GluR6-9c can be used to study cerebral ischemia and neuroprotective strategies .

HY-128326

ZAK-IN-1	MAP3K	Cardiovascular Disease
ZAK-IN-1 is an orally active and selective selective leucine-zipper and sterile‑α motif kinase (ZAK) inhibitor with IC₅₀ of 4 nM and K_D of 8 nM. ZAK-IN-1 exhibits excellent selectivity against a panel of 403 wild-type kinases. ZAK-IN-1 blocks p38/GATA-4 and JNK/c-Jun signaling and shows promising anti antihypertrophic cardiomyopathy (HCM) efficacy. ZAK-IN-1 can be used for the study of HCM .

HY-101287

MPT0B392	Microtubule/Tubulin JNK Apoptosis Caspase	Cancer
MPT0B392, an orally active quinoline derivative, induces *c-Jun* N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing** agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line .

HY-155593

JNK-1-IN-2	JNK	Inflammation/Immunology
JNK-1-IN-2 (Compound c6) is a JNK-1 inhibitor (IC₅₀: 33.5 nM). JNK-1-IN-2 also inhibits JNK-2 and JNK-3 with IC₅₀s of 112.9 nM and 33.2 nM. JNK-1-IN-2 inhibits the phosphorylation of c-Jun. JNK-1-IN-2 reverses lung impairment. JNK-1-IN-2 can be used for research of pulmonary fibrosis .

HY-169021

JNK-1-IN-3	JNK	Cancer
JNK-1-IN-3 (Compound 9e) is an inhibitor of JNK1 that downregulates JNK1 gene expression and inhibits the protein levels of its phosphorylated form, concurrently reducing the expression of its downstream targets, *c-Jun* and c-Fos, in tumors while restoring p53 activity. JNK-1-IN-3 exhibits broad-spectrum antiproliferative activity, particularly with high inhibitory activity against renal and breast cancer cell lines, demonstrating both in vivo and in vitro anticancer activity .

HY-168859

JNK3 inhibitor-9	JNK GSK-3 Amyloid-β	Neurological Disease
JNK3 inhibitor-9 (Compound 24a) is a potent, selective and BBB-permeable JNK3 inhibitor with an IC₅₀ value of 12 nM. JNK3 inhibitor-9 also potently inhibits GSK3α/β (IC₅₀s: 14 and 35 nM, respectively) involved in Tau phosphorylation. JNK3 inhibitor-9 reduces *c-Jun* and APP phosphorylation. JNK3 inhibitor-9 protects neurons from Aβ_1-42 toxicity .

HY-12270R

T-5224 (Standard)	AP-1 MMP	Others
T-5224 (Standard) is the analytical standard of T-5224. This product is intended for research and analytical applications. T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Cat. No.	Product Name

HY-L010

MAPK Compound Library

802 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 802 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-D2898

Jun14157	Fluorescent Dyes/Probes
Jun14157 is a fluorescence polarization probe that can specifically bind to the conserved allosteric site of enterovirus 2C proteins (Ex: 485/20; Em: 528/20). Jun14157 has K_d values of 2.3 μM, 1.4 μM, and 1.1 μM for EV-D68 2C, EV-A71 2C, and CVB3 2C, respectively. Jun14157 can be used in research related to enteroviruses .

Cat. No.	Product Name	Type

HY-141582

Ceramide 3

N-Stearoyl phytosphingosine

Drug Delivery

C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation.

Cat. No.	Product Name	Target	Research Area

HY-P1190

*c-JUN* peptide**	JNK Apoptosis	Inflammation/Immunology
c-JUN peptide is a cell-permeable c-JUN-JNK interaction inhibitor. c-JUN peptide inhibits serum-induced c-Jun phosphorylation. c-JUN peptide induces apoptosis .

HY-P10506

CMX-8933	JNK	Neurological Disease
CMX-8933 is an octapeptide fragment of the goldfish brain neurotrophic factor ependymin. CMX-8933 increases the enzymatic activity of c-Jun N-terminal kinase (JNK), increases the phosphorylation of JNK and c-Jun proteins, and increases the cellular levels of c-Jun and c-Fos mRNA. CMX-8933 can be used to study the role of ependymin in neuroplasticity, learning, memory formation, and neural regeneration .

HY-P4699

*(Thr17)-c-Jun* (11-23)**	JNK	Others
(Thr17)-c-Jun (11-23) is a fragment peptide of c-Jun.

HY-P10048

TAT-JIP	JNK	Inflammation/Immunology
TAT-JIP inhibits the phosphorylation of endogenous c-jun activated by PHA–PMA .

HY-P6177

SGP8	Dipeptidyl Peptidase	Inflammation/Immunology
SGP8 (IAVPGEVA) is an octapeptide produced by hydrolysis of soybean 11S globulin, which has the effects of regulating lipid metabolism, inflammation and fibrosis. SGP8 (IAVPGEVA) exhibits inhibitory activity against DPP4 and inhibits the *JNK-c-Jun* signaling pathway, and has the ability to inhibit non-alcoholic steatohepatitis (NASH) .

HY-P10401

TAT-GluR6-9c	Apoptosis iGluR	Cardiovascular Disease Neurological Disease
TAT-GluR6-9c is a GluR6-PSD95 interaction blocker. By regulating the GluR6 mediated signaling pathway, TAT-GluR6-9c inhibits the activation of JNK and phosphorylation of c-Jun, reduces the expression of Fas L and thus reduces the occurrence of apoptosis. TAT-GluR6-9c can be used to study cerebral ischemia and neuroprotective strategies .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1961

Ophiopogonin B OP-B	Other Terpenoids Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Asparagaceae Juss. Cancer	JNK Apoptosis
Ophiopogonin B (OP-B) induces the autophagy and apoptosis of colon cancer cells by activating *JNK/c-Jun* signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus .

HY-113443

12(S)-HPETE	Microorganisms Source classification	AP-1
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension .

Species:	Human (8) Mouse (1)
Tag:	His (5) Tag Free (2) Strep (1) Myc (1) GST (3) Fc (1)
Source:	sf9 insect cells (1) Sf9 insect cells (3) P. pastoris (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P702589

	JUN Protein, Human (His, Myc) Activator protein 1; AP1; Proto-oncogene c-JUN; Transcription factor AP-1 subunit JUN; V-JUN avian sarcoma virus 17 oncogene homolog; p39	Human	E. coli
	JUN Protein, Human (His, Myc) is the recombinant human-derived JUN, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P701437

	COPS5 Protein, Human COPS5; COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; JUN activation domain-binding protein 1	Human	E. coli
	The COPS5 protein is a possible protease subunit of the COP9 signalosome complex (CSN) and regulates the ubiquitin conjugation pathway by demethylating the cullin subunit of the SCF-type E3 ligase complex. This activity reduces Ubl ligase activity, affecting complexes such as SCF, CSA, or DDB2. COPS5 Protein, Human is the recombinant human-derived COPS5 protein, expressed by E. coli , with tag free.

HY-P704548

	COPS5 Protein, Human (Sf9, Fc) COPS5; COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; JUN activation domain-binding protein 1	Human	sf9 insect cells
	The COPS5 protein is a possible protease subunit of the COP9 signalosome complex (CSN) and regulates the ubiquitin conjugation pathway by demethylating the cullin subunit of the SCF-type E3 ligase complex. This activity reduces Ubl ligase activity, affecting complexes such as SCF, CSA, or DDB2. COPS5 Protein, Human (Sf9, Fc) is the recombinant human-derived COPS5 protein, expressed by sf9 insect cells, with C-hFc labeled tag.

HY-P705421

	JNK1 Protein, Mouse (Active, sf9, GST) MAP kinase 8; MAPK 8; Stress-activated protein kinase JNK1; c-JUN N-terminal kinase 1; Mapk8	Mouse	Sf9 insect cells

HY-P701791

	JNK3 Protein, Human (His) MAPK10; Mitogen-activated protein kinase 10; MAP kinase 10; MAPK 10; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-JUN N-terminal kinase 3	Human	E. coli
	JNK3 is a critical serine/threonine protein kinase in neuronal processes, regulating proliferation, differentiation, migration, and apoptosis. Activation through MAP2K4/MKK4 and MAP2K7/MKK7 leads to phosphorylation of JNK3, which in turn phosphorylates AP-1 components such as JUN and ATF2, thereby regulating AP-1 transcriptional activity. JNK3 Protein, Human (His) is the recombinant human-derived JNK3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701790

	JNK3 Protein, Human (364a.a, His) MAPK10; Mitogen-activated protein kinase 10; MAP kinase 10; MAPK 10; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-JUN N-terminal kinase 3	Human	E. coli
	JNK3 is a critical serine/threonine protein kinase in neuronal processes, regulating proliferation, differentiation, migration, and apoptosis. Activation through MAP2K4/MKK4 and MAP2K7/MKK7 leads to phosphorylation of JNK3, which in turn phosphorylates AP-1 components such as JUN and ATF2, thereby regulating AP-1 transcriptional activity. JNK3 Protein, Human is the recombinant human-derived JNK3 protein, expressed by E. coli , with tag free.

HY-P704064

	MAP2K4 Protein, Human (sf9, His, StrepⅡ, GST) Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4 (MEK 4); SAPK/ERK kinase 1 (SEK1); Stress-activated protein kinase kinase 1 (SAPK kinase 1; SAPKK-1; SAPKK1); c-JUN N-terminal kinase kinase 1 (JNKK)	Human	Sf9 insect cells
	The MAP2K4 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K4 Protein, Human (sf9, His, StrepⅡ, GST) is the recombinant human-derived MAP2K4 protein, expressed by Sf9 insect cells, with N-His and N-GST and N-StrepⅡ labeled tag.

HY-P700589

	MAP2K4 Protein, Human (P. pastoris, His-GST) MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase 1; JNK activating kinase 1; JNK-activating kinase 1; c-JUN N-terminal kinase kinase 1; stress-activated protein kinase kinase 1; JNKK; SEK1; MAPKK4; SAPKK1; SAPKK-1	Human	P. pastoris
	The MAP2K4 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K4 Protein, Human (P. pastoris, His-GST) is the recombinant human-derived MAP2K4 protein, expressed by P. pastoris , with N-6*His, N-GST labeled tag.

HY-P702841

	MAP2K4 Protein, Human (sf9) MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase 1; JNK activating kinase 1; JNK-activating kinase 1; c-JUN N-terminal kinase kinase 1; stress-activated protein kinase kinase 1; JNKK; SEK1; MAPKK4; SAPKK1; SAPKK-1	Human	Sf9 insect cells
	The MAP2K4 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K4 Protein, Human (sf9) is the recombinant human-derived MAP2K4 protein, expressed by sf9 insect cells , tag free.

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Cat. No.	Product Name	Chemical Structure

HY-B1198S

Piperonyl butoxide-d9
Piperonyl butoxide-d₉ is the deuterium labeled Piperonyl butoxide.Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate *c-Jun* and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .

HY-141582S

Ceramide 3-d3

Ceramide 3-d₃ (N-Stearoyl phytosphingosine-d₃) is deuterium labeled Ceramide 3. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80084

	*c-Jun* Antibody (YA503)** 1 Publications Verification	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	c-Jun Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to c-Jun. It can be used for WB,ICC,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80456

	*Phospho-c-Jun(Ser63) Antibody (YA214)*	WB, ICC/IF, IHC-P	Human
	Phospho-c-Jun(Ser63) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to Phospho-c-Jun(S63). It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human.

HY-P80800

	*Phospho-c-Jun* (Ser243) Antibody** Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-JUN; V-JUN avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser243) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 36 kDa, targeting to Phospho-c-Jun (Ser243). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80802

	*Phospho-c-Jun* (Ser73) Antibody** Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-JUN; V-JUN avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser73) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 36 kDa, targeting to Phospho-c-Jun (Ser73). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80801

	*Phospho-c-Jun* (Ser63) Antibody (YA215)** Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-JUN; V-JUN avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser63) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to Phospho-c-Jun (Ser63). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P83414

	JAB1 Antibody (YA3159) COPS5; CSN5; JAB1; COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; JUN activation domain-binding protein 1	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	JAB1 Antibody (YA3159) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3159), targeting JAB1, with a predicted molecular weight of 38 kDa (observed band size: 38 kDa). JAB1 Antibody (YA3159) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P80728

	JNK Antibody (YA329) 3 Publications Verification AI849689 antibody; c JUN N terminal kinase 1 antibody; C-JUN kinase 1 antibody; c-JUN N-terminal kinase 1 antibody; EC 2.7.11.24 antibody; JNK 1 antibody; JNK antibody; JNK-46 antibody; JNK1A2 antibody; JNK21B1/2 antibody; MAP kinase 8 antibody; MAPK 8 antibody; mapk8 antibody; Mitogen activated protein kinase 8 antibody; MK08_HUMAN antibody; p54 gamma antibody; Prkm8 antibody; Protein kinase JNK1 antibody; Protein kinase, mitogen-activated, 8 antibody; SAPK 1 antibody; SAPK gamma antibody; SAPK1 antibody; Stress-activated protein kinase 1 antibody	WB, IP	Human, Mouse, Rat, Hamster
	JNK Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to JNK. It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat, Hamster.

HY-P83960

	*c-Jun* Antibody (YA3657)** AP1; AP-1; c-JUN; JUN	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey
	c-Jun Antibody (YA3657) is a mouse-derived and non-conjugated IgG1 antibody, targeting to c-Jun. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, monkey.

HY-P82861

	*Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606)* JUN; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-JUN; V-JUN avian sarcoma virus 17 oncogene homolog; p39; JUND; Transcription factor JUN-D	WB, IP	Human, Mouse, Rat
	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2606), targeting Phospho-Jun/JunD (Ser73/Ser100), with a predicted molecular weight of 36 kDa (observed band size: 38,42,48 kDa). Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) can be used for WB, IP experiment in human, mouse, rat background.

HY-P83342

	Phospho-JunD (Ser255) Antibody (YA3087) Activator protein 1; AP 1; JUN D; JUN D proto oncogene; JUNd; JUND FL isoform; Transcription factor JUN D	WB, IP	Human, Mouse, Rat
	Phospho-JunD (Ser255) Antibody (YA3087) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3087), targeting Phospho-JunD (Ser255), with a predicted molecular weight of 35 kDa (observed band size: 38,42 kDa). Phospho-JunD (Ser255) Antibody (YA3087) can be used for WB, IP experiment in human, mouse, rat background.

HY-P80729

	JNK1 Antibody (YA720) AI849689 antibody; c JUN N terminal kinase 1 antibody; C-JUN kinase 1 antibody; c-JUN N-terminal kinase 1 antibody; EC 2.7.11.24 antibody; JNK 1 antibody; JNK antibody; JNK-46 antibody; JNK1A2 antibody; JNK21B1/2 antibody; MAP kinase 8 antibody; MAPK 8 antibody; mapk8 antibody; Mitogen activated protein kinase 8 antibody; MK08_HUMAN antibody; p54 gamma antibody; Prkm8 antibody; Protein kinase JNK1 antibody; Protein kinase, mitogen-activated, 8 antibody; SAPK 1 antibody; SAPK gamma antibody; SAPK1 antibody; Stress-activated protein kinase 1 antibody	WB, ICC/IF	Human, Mouse, Rat
	JNK1 (1A4) Antibody is a non-conjugated and Mouse origined monoclonal antibody about 48 kDa, targeting to JNK1 (1A4). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80831

	Phospho-JNK1 (Thr183/Tyr185) Antibody (YA180) AI849689 antibody; c JUN N terminal kinase 1 antibody; C-JUN kinase 1 antibody; c-JUN N-terminal kinase 1 antibody; EC 2.7.11.24 antibody; JNK 1 antibody; JNK antibody; JNK-46 antibody; JNK1A2 antibody; JNK21B1/2 antibody; MAP kinase 8 antibody; MAPK 8 antibody; mapk8 antibody; Mitogen activated protein kinase 8 antibody; MK08_HUMAN antibody; p54 gamma antibody; Prkm8 antibody; Protein kinase JNK1 antibody; Protein kinase, mitogen-activated, 8 antibody; SAPK 1 antibody; SAPK gamma antibody; SAPK1 antibody; Stress-activated protein kinase 1 antibody	WB, IP	Human, Rat
	Phospho-JNK1 (Thr183/Tyr185) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to Phospho-JNK1 (Thr183/Tyr185). It can be used for WB,IP assays with tag free, in the background of Human, Rat.

HY-P85598

	JNK1 Antibody (YA5290) AI849689; c JUN N terminal kinase 1; C-JUN kinase 1; c-JUN N-terminal kinase 1; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; MK08_HUMAN; p54 gamma; PRKM 8; PRKM8; Protein kinase JNK1; Protein kinase, mitogen-activated, 8; SAPK 1; SAPK gamma; SAPK1; Stress activated protein kinase JNK1; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1; Tyrosine protein kinase JAK1 .	WB, ICC/IF	Human, Mouse, Rat
	JNK1 Antibody (YA5290) is a mouse-derived and non-conjugated monoclonal antibody, targeting to JNK1. It can be applicated for WB, ICC/IF assays, in the background of human, mouse, rat.

HY-P85717

	JNK2 Antibody (YA5409) Mitogen-activated protein kinase 9; MAP kinase 9; MAPK 9; JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-JUN N-terminal kinase 2;	IHC-P	Human, Mouse, Rat
	JNK2 Antibody (YA5409) is a mouse-derived and non-conjugated monoclonal antibody, targeting to JNK2. It can be applicated for IHC-P assays, in the background of human, mouse, rat.

HY-P86106

	JNK2 Antibody (YA5798) MAPK9; JNK2; PRKM9; SAPK1A; Mitogen-activated protein kinase 9; MAP kinase 9; MAPK 9; JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-JUN N-terminal kinase 2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	JNK2 Antibody (YA5798) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to JNK2. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P85237

	JNK3 Antibody (YA4929) MAPK10; JNK3; JNK3A; PRKM10; SAPK1B; Mitogen-activated protein kinase 10; MAP kinase 10; MAPK 10; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-JUN N-terminal kinase 3	WB, ICC/IF, ELISA	Human, Mouse
	JNK3 Antibody (YA4929) is a mouse-derived and non-conjugated monoclonal antibody, targeting to JNK3. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human, mouse.

HY-P86251

	JNK1/2/3 Antibody (YA5943) MAPK8; JNK1; PRKM8; SAPK1; SAPK1C; Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-JUN N-terminal kinase 1; MAPK9; JNK2; PRKM9; SAPK1A; Mi	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	JNK1/2/3 Antibody (YA5943) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to JNK1/2/3. It can be applicated for WB, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.