2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. c-Jun Antibody (YA503)

c-Jun Antibody (YA503) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Jun.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

Publications Citing Use of MCE c-Jun Antibody (YA503)

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

c-Jun Antibody (YA503) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Jun.
Background

c-Jun is a transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3'. It heterodimerizes with FOS family proteins to form the AP-1 transcription complex, enhancing both DNA binding and transcriptional activity (by similarity). Together with FOSB, it participates in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L and inducing its transcription upon TCR/CD3 signaling pathway activation. When phosphorylated by HIPK3, c-Jun promotes NR5A1 activity, boosting steroidogenic gene expression in response to cAMP pathway stimulation. In colorectal cancer (CRC) cells, it mediates KRAS-activated transcriptional upregulation of USP28 and directly binds to the USP28 promoter. During Epstein-Barr virus (EBV) infection, c-Jun binds to the viral BZLF1 Z promoter to activate BZLF1 expression.
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 36 kDa; Observed band size: 40 kDa
Purity

Protein A affinity purified.
Subcellular Location

Nucleus.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:1,000 ;ICC: 1:100-1:500 ;IHC-P: 1:50-1:800 ;IP: Use at an assay dependent concentration.
Application

WB, IHC-P, ICC/IF, IP
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic peptide corresponding to Human c-Jun.The exact sequence is proprietary to MCE.
Database

Entrez Gene: 3725 Human ; 16476 Mouse ; 24516 Rat

SwissProt: P05412 Human ; P05627 Mouse ; P17325 Rat

OMIM: 165160 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

c-Jun Antibody (YA503) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
c-Jun Antibody (YA503)
Cat. No.:
HY-P80084
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