2. MAPK/ERK Pathway NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. JNK Reactive Oxygen Species (ROS)
  4. JNK-9L

JNK-9L (Compound 9l) is a BBB-penetrable and ATP-competitive JNK inhibitor with IC50s of 0.099 and 0.148  μM for JNK1 and JNK3, respectively. JNK-9L significantly inhibits c-jun phosphorylation and Streptozotocin (HY-13753)-induced ROS generation with an IC50 of 0.8  nM. JNK-9L can be used for neurodegenerative disorders like Parkinson’s disease research.

For research use only. We do not sell to patients.

JNK-9L

JNK-9L Chemical Structure

CAS No. : 1128096-64-9

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JNK-9L Related Antibodies

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Description

JNK-9L (Compound 9l) is a BBB-penetrable and ATP-competitive JNK inhibitor with IC50s of 0.099 and 0.148  μM for JNK1 and JNK3, respectively. JNK-9L significantly inhibits c-jun phosphorylation and Streptozotocin (HY-13753)-induced ROS generation with an IC50 of 0.8  nM. JNK-9L can be used for neurodegenerative disorders like Parkinson’s disease research[1].

IC50 & Target[1]

JNK1

0.099 μM (IC50)

JNK3

0.148 μM (IC50)

Molecular Weight

502.54

Formula

C26H27FN8O2
CAS No.
SMILES

FC1=CC(C2=NC(NC(C=C3)=CC=C3N4C=NC(N5CCOCC5)=N4)=NC=C2)=CC(N6CCOCC6)=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNK-9L Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-9L1128096-64-9JNKReactive Oxygen Species (ROS)c-Jun N-terminal kinaseATP-competitiveNeurodegenerative disordersParkinson’s diseaseINS-1 cellsInhibitorinhibitorinhibit

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