Search Result

Results for "

IL-1β Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (186) IRAK (1) Acetyl-CoA Carboxylase (2) ADAMTS (1) ADC Payload (1) Adrenergic Receptor (4) AIM2 (2) Akt (12) Aldehyde Dehydrogenase (ALDH) (2) AMPK (7) Amyloid-β (5) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (9) AP-1 (2) Apoptosis (31) Arginase (1) Autophagy (11) Bacterial (16) Bcl-2 Family (5) Biochemical Assay Reagents (2) BMX Kinase (1) Btk (2) Calcium Channel (2) Cannabinoid Receptor (2) Caspase (34) Cathepsin (3) CD22 (1) CDK (4) Cholecystokinin Receptor (3) Cholinesterase (ChE) (2) Collagen (1) COX (34) Cuproptosis (2) Cytochrome P450 (3) Dengue Virus (1) Deubiquitinase (1) Dipeptidyl Peptidase (1) Drug Derivative (4) Drug Isomer (1) Drug Metabolite (4) E1/E2/E3 Enzyme (1) EGFR (1) Endogenous Metabolite (18) Enterovirus (1) Ephrin Receptor (3) Epigenetic Reader Domain (2) ERK (12) Ferroptosis (5) FGFR (1) Formyl Peptide Receptor (FPR) (1) FOXO (1) FXR (1) GABA Receptor (2) Glucocorticoid Receptor (4) GLUT (1) Glutathione Peroxidase (4) Glutathione S-transferase (1) GSK-3 (3) HDAC (1) Heme Oxygenase (HO) (4) HIF/HIF Prolyl-Hydroxylase (10) HIV Protease (1) HSP (2) IFNAR (1) IKK (6) Indoleamine 2,3-Dioxygenase (IDO) (1) Integrin (1) Isotope-Labeled Compounds (10) JAK (2) JNK (5) Keap1-Nrf2 (10) Lactate Dehydrogenase (3) Lipoxygenase (3) Macrophage migration inhibitory factor (MIF) (1) MAP3K (6) MAPKAPK2 (MK2) (1) MDM-2/p53 (7) mGluR (1) MHC (1) MicroRNA (1) Mitochondrial Metabolism (1) MMP (13) Molecular Glues (2) Monoamine Oxidase (3) mTOR (3) MyD88 (3) nAChR (3) NADPH Oxidase (1) NEKs (6) Neurokinin Receptor (1) NF-κB (66) NO Synthase (38) NOD-like Receptor (NLR) (79) Notch (1) OAT (1) P-glycoprotein (2) P2X Receptor (2) p38 MAPK (33) Parasite (3) PARP (4) PCSK9 (2) PD-1/PD-L1 (1) PDI (1) PERK (5) PGC-1α (4) PGE synthase (3) Phosphatase (1) Phosphodiesterase (PDE) (3) Phospholipase (1) PI3K (3) PIKfyve (1) PKA (1) PKC (2) Polo-like Kinase (PLK) (1) Potassium Channel (2) PPAR (11) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (1) PROTACs (2) Proteasome (1) Pyroptosis (13) Pyruvate Kinase (2) Raf (1) Reactive Oxygen Species (ROS) (22) Reference Standards (37) Renin (2) REV-ERB (1) RIP kinase (1) ROS Kinase (5) SARS-CoV (4) SGLT (1) Small Interfering RNA (siRNA) (2) SOD (5) SphK (1) STAT (9) Tau Protein (1) TNF Receptor (61) Toll-like Receptor (TLR) (5) TREM receptor (2) Tyrosinase (3) URAT1 (1) VEGFR (7) Virus Protease (1) Wnt (2) YTHDF (1) β-catenin (1)
By Research Areas:	Cancer (80) Cardiovascular Disease (50) Endocrinology (15) Infection (32) Inflammation/Immunology (281) Metabolic Disease (24) Neurological Disease (60)
Click Chemistry:	Alkynes (4)
Oligonucleotides:	siRNA drugs (2) Cholesterol (1) siRNAs (2)

340

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

101

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148258

GDC-2394	NOD-like Receptor (NLR) Interleukin Related Caspase	Inflammation/Immunology
GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits *IL-1β* with IC₅₀s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation .

HY-132831

Selnoflast 1 Publications Verification Somalix; RO-7486967; IZD334	NOD-like Receptor (NLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Selnoflast (RO7486967), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast is a potent inhibitor of *IL-1β* release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease .

HY-P99721

Lutikizumab ABT-981	Interleukin Related	Inflammation/Immunology
Lutikizumab (ABT-981) is an anti-IL-1α and *IL-1β* dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis .

HY-N8304

Shegansu B (+)-Shegansu B; Parvifolol D	Interleukin Related	Inflammation/Immunology
Shegansu B is an inhibitor of *IL-1β. Shegansu B 6 inhibits* IL-1β expression on LPS-induced THP-1 cells with 64.74% inhibition. Shegansu B has anti-inflammatory activity .

HY-156340

Anti-inflammatory agent 58	Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 58 is an anti-inflammatory agent. Anti-inflammatory agent 58 inhibits *IL-1β* with an IC₅₀ of 1.08 μM. Anti-inflammatory agent 58 decreases pro-inflammatory gene expression, protein secretion, and NF-κB phosphorylation .

HY-156342

Anti-inflammatory agent 59	Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 59 is an anti-inflammatory agent. Anti-inflammatory agent 58 inhibits *IL-1β* with an IC₅₀ of 2.28 μM. Anti-inflammatory agent 58 decreases pro-inflammatory gene expression, protein secretion, and NF-κB phosphorylation .

HY-164765

NLRP3-IN-56	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-56 (compound 062) is a NLRP3 inhibitor. NLRP3-IN-56 potently inhibits the level of IL-1β secretion by THP-1 cells with an IC₅₀ of 9.7 nM. NLRP3-IN-56 can be used for the study of NLRP3-mediated symptoms and/or diseases .

HY-130480

Fructose-arginine	AIM2	Inflammation/Immunology
Fructose-arginine, an amino-sugar, is an AIM2 inflammasome activation inhibitor. Fructose-arginine attenuates the secretion of IL-1β, IL-18, and caspase-1, and Asc pyroptosome formation and Gsdmd cleavage resulting from AIM2 inflammasome activation .

HY-175182

IDO1-IN-27	Indoleamine 2,3-Dioxygenase (IDO) TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
IDO1-IN-27 (Compound I-1) is a Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor with an IC₅₀ of 0.3951  μM for recombinant hIDO1. IDO1-IN-27 also inhibits hIDO1 expression in HeLa cells (EC₅₀: 62 nM). IDO1-IN-27 effectively stimulates T cell proliferation by reducing the mRNA expression of pro-inflammatory factors (TNF-α, IL-6, and IL-1β) while concurrently inhibiting LLC cells growth .

HY-133133

IIIM-1270	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
IIIM-1270is a NLRP3 inflammasome inhibitor. IIIM-1270 inhibits *IL-1β* release in mouse macrophages (J774A.1 cells) (IC₅₀ = 3.5 μM) and significantly reduced the protein expression level of mature *IL-1β*. IIIM-1270 can be used for the study of inflammation .

HY-133132

IIIM-1266	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
IIIM-1266 is a NLRP3 inflammasome inhibitor. IIIM-1266 inhibits *IL-1β* release in mouse macrophages (J774A.1 cells) (IC₅₀ = 2.3 μM) and significantly reduced the protein expression level of mature *IL-1β*. IIIM-1266 can be used for the study of inflammation .

HY-149282

IL-1β-IN-2	Interleukin Related	Neurological Disease Inflammation/Immunology
IL-1β-IN-2, cannabigerol derivative, is a potent *IL-1β* inhibitor. IL-1β-IN-2 has anti-inflammatory and pain-resolving properties .

HY-149281

IL-1β-IN-1	Interleukin Related	Neurological Disease Inflammation/Immunology
IL-1β-IN-1, cannabidiol derivative, is a potent *IL-1β* inhibitor. IL-1β-IN-1 has anti-inflammatory and pain-resolving properties .

HY-114573

TNF-α-IN-19	IKK Interleukin Related TNF Receptor RIP kinase	Others
TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC₅₀ values for TNFα, *IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits* the degradation of IκBα when cells are stimulated by TNFα and not by *IL-1β* .

HY-110133

JTE-607 3 Publications Verification	Interleukin Related	Inflammation/Immunology
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, *IL-1β, IL-6, IL-8* and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively . Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 .

HY-156647

Usnoflast	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
Usnoflast is the selective, orally active inhibitor for NLRP3 that blocks the release of IL-1β, and exhibits anti-inflammatory activity .

HY-N0604

Ginsenoside Rh1 4 Publications Verification Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1	Interleukin Related PPAR TNF Receptor Endogenous Metabolite	Inflammation/Immunology
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and *IL-1β*.

HY-119721

CP-424174	NOD-like Receptor (NLR)	Inflammation/Immunology
CP-424174 is a reversible inhibitor against *IL-1β* processing with an IC₅₀ of 210 nM.CP-424174 indirectly inhibits NLRP3 .

HY-110133A

JTE-607 free base	Interleukin Related	Inflammation/Immunology
JTE-607 free base, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 free base inhibits inflammatory cytokine production, including TNF-α, *IL-1β, IL-6, IL-8* and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively . Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 free base .

HY-123605

CAY10406	Caspase	Others
CAY10406 is an inhibitor for caspase 3/7. CAY10406 inhibits the expression of 28-kDa IL-1β fragment, without significant cytotoxicity (10 μM) .

HY-101860

GIBH-130 3 Publications Verification	Interleukin Related	Neurological Disease
GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses the *IL-1β* secretion by activated microglia (IC₅₀=3.4 nM).

HY-N13262

Dactyllactone A	Interleukin Related	Inflammation/Immunology
Dactyllactone A is an isoquinoline alkaloid that can be isolated from Dactylicapnos scandens. Dactyllactone A shows anti-inflammatory activity. Dactyllactone A inhibits the expression of IL-1β and PGE2 .

HY-123876

AS2677131	PIKfyve Interleukin Related MHC	Inflammation/Immunology
AS2677131 is a potent and orally active PIKfyve inhibitor. AS2677131 inhibits f IL-12p40, IL-6 and IL-1β through a PIKfyve-c-Rel pathway. AS2677131 selectively inhibits DNA-binding activity of c-Rel to IL-12p40 and IL-1β promoter. AS2677131 inhibits MHC class II expression on B cells. AS2677131 can be used for the researches of inflammation and immunology, such as arthritis .

HY-P991670

Abdakibart	Interleukin Related	Inflammation/Immunology
Abdakibart is a humanized IgG4 monoclonal antibody inhibitor targeting *IL-1β*. Abdakibart can be used for inflammatory disease like type 2 diabetes research .

HY-P991269

LY2189102	Interleukin Related	Metabolic Disease
LY2189102 is a humanized monoclonal antibody inhibitor targeting interleukin-1β (IL-1β). LY2189102 is promising for research of type 2 diabetes .

HY-120152

SLP7111228	SphK	Inflammation/Immunology
SLP7111228 is a SphK1 inhibitor. SLP7111228 reduces LPS-induced TNFα and IL-1β production. SLP7111228 can be used in neuroinflammatory diseases research .

HY-16990

Ac-YVAD-cmk 25+ Cited Publications Caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases .

HY-168561

NLRP3-IN-58	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
NLRP3-IN-58 (Compound DS15) is an inhibitor for the activation of NLRP3 inflammasome with an IC₅₀ of 3.85 μM, and inhibits 33% IL-1β release at a concentration of 10 μM .

HY-N15305

Ferolin	FXR	Inflammation/Immunology
Ferolin is the agonist for farnesoid X receptor (FXR) with an EC₅₀ of 0.56 µM. Ferolin inhibits the expression of inflammatory genes (such as iNOS, IL-1β and TNFα) upon the FXR activation .

HY-147119

INX-SM-6	ADC Payload	Inflammation/Immunology
INX-SM-6 can be used for targeted delivery of anti-inflammatory agent. INX-SM-6 inhibits LPS-induced IL-1β production in human PBMCS .

HY-168520

NLRP3-IN-57	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, thereby reducing *IL-1β* levels in LPS plus Nigericin-induced THP-1 macrophages. .

HY-N0042

Ginsenoside Rc Panaxoside Rc	GABA Receptor TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptor_A (GABA_A)-mediated ion channel currents (I_GABA). Ginsenoside Rc inhibits the expression of TNF-α and *IL-1β*.

HY-126414

Methylenedihydrotanshinquinone	Others	Inflammation/Immunology
Methylenedihydrotanshinquinone is a natural product that can be isolated from the dried root of S. miltiorrhiza. Methylenedihydrotanshinquinone has anti-inflammatory effect by inhibiting expression of TNF-α, IL-1β, and IL-8 .

HY-120048

NBC19	NOD-like Receptor (NLR)	Inflammation/Immunology
NBC19 is an NLRP3 inflammasome inhibitor with an IC₅₀ of 60 nM in differentiated THP1 cells. NBC19 inhibits nigericin- and ATP-induced IL-1β release with IC₅₀s of 80 nM and 850 nM, respectively .

HY-157554

ZM640	NOD-like Receptor (NLR)	Inflammation/Immunology
ZM640 is a NLRP3 inhibitor. ZM640 enhances IL-1β release mediated by NLRP3 inflammasome activation in THP-1 cells. ZM640 shows low cytotoxicity .

HY-146564A

HP210	Glucocorticoid Receptor	Inflammation/Immunology
HP210 is a selective glucocorticoid receptor modulator (SGRM). HP210 can inhibit the mRNA expression of IL-1β and IL-6. HP210 has the potential to study inflammation-related diseases .

HY-168130

TNF-α/IL-1β-IN-1	TNF Receptor Interleukin Related	Cardiovascular Disease
TNF-α/IL-1β-IN-1 (compund 11a) is an anti-inflammatory agent that reduces the expression of TNF-α and IL-1β, inhibits oxidative stress and cardiomyocyte apoptosis, has good activity against septic myocardial injury, and improves myocardial blood supply in vivo .

HY-169933

NEK7-IN-1	NEKs	Inflammation/Immunology Cancer
NEK7-IN-1 (Compound I-15) is the inhibitor for NIMA-related kinase 7 NEK7 with IC₅₀ <100 nM. NEK7-IN-1 inhibits the IL-1β release with IC₅₀ <50 nM .

HY-131668

9-POHSA	Endogenous Metabolite	Inflammation/Immunology
9-POHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 9-POHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression .

HY-173046

NLRP3-IN-71	NOD-like Receptor (NLR) Interleukin Related	Neurological Disease Inflammation/Immunology
NLRP3-IN-71 (Compound 19) is a BBB-permeable, orally active and selective NLRP3 inhibitor that can inhibit *IL-1β* secretion. NLRP3-IN-71 can be used for the research of neurodegenerative diseases .

HY-P11296

LLVK	IKK NF-κB	Inflammation/Immunology
LLVK is a selective IκB phosphorylation inhibitor. LLVK reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α). LLVK is promising for research of inflammatory bowel disease and rheumatoid arthritis .

HY-117432

JC-171	NOD-like Receptor (NLR)	Inflammation/Immunology
JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC₅₀ of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages .

HY-150965

NDT-30805	NOD-like Receptor (NLR)	Inflammation/Immunology
NDT-30805 is a selective NLRP3 inflammasome inhibitor. NDT-30805 is a triazolopyrimidinone derivative and inhibits IL-1β release in PBMCs with an IC₅₀ of 0.013 μM. NDT-30805 can be used for the research of inflammation and innate immunity .

HY-101019

Ossirene 2 Publications Verification AS101	Interleukin Related Caspase	Inflammation/Immunology Cancer
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent *IL-1β* inhibitor . Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits Caspase-1 and is used for the autoimmune diseases and certain malignancies .

HY-137007

SMA-12b	Interleukin Related	Others Inflammation/Immunology
SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine *IL-1β* associated with inflammatory bodies and inhibites the production of *IL-1β* through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases .

HY-145087A

NP3-146 sodium	NOD-like Receptor (NLR) Interleukin Related Caspase	Inflammation/Immunology
NP3-146 sodium is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3. NP3-146 sodium shows potent inhibitory activity against *IL-1β* release with an IC₅₀ value of 0.171 μM in LPS (HY-D1056)/Nigericin (HY-127019)-stimulated BMDM cells. NP3-146 sodium regulates the levels of cleaved Caspase-1 and cleaved *IL-1β* in cell supernatants. NP3-146 sodium can be used for the research of inflammatory diseases .

HY-145087

NP3-146 NLRP3-IN-5	NOD-like Receptor (NLR) Interleukin Related Caspase	Inflammation/Immunology
NP3-146 is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3. NP3-146 shows potent inhibitory activity against *IL-1β* release with an IC₅₀ value of 0.171 μM in LPS (HY-D1056)/Nigericin (HY-127019)-stimulated BMDM cells. NP3-146 regulates the levels of cleaved Caspase-1 and cleaved *IL-1β* in cell supernatants. NP3-146 can be used for the research of inflammatory diseases .

HY-173591

T0080	Formyl Peptide Receptor (FPR) Apoptosis Reactive Oxygen Species (ROS) Interleukin Related	Cardiovascular Disease
T0080 is a FPR-1 antagonist. T0080 reduces the cell apoptosis, inhibits ROS production and pro-inflammatory cytokines (TNF-α and IL-1β) from plaque macrophages, which attenuates atherosclerotic progression in ApoE ^−/− mice .

HY-W650842

Boc-Asp(OBzl)-CMK	Caspase	Cancer
Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein .

HY-N0604R

Ginsenoside Rh1 (Standard) Prosapogenin A2 (Standard); Sanchinoside B2 (Standard); Sanchinoside Rh1 (Standard)	Interleukin Related Reference Standards PPAR TNF Receptor Endogenous Metabolite	Inflammation/Immunology
Ginsenoside Rh1 (Standard) is the analytical standard of Ginsenoside Rh1. This product is intended for research and analytical applications. Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.

Cat. No.	Product Name	Type

HY-108775A

Sodium thiosulfate (99%, water≤1.0%)

Sodium hyposulfite (99%, water≤1.0%)

Buffer Reagents

Sodium thiosulfate is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease .

HY-W342458

Betamethasone 17-Propionate

Cell Assay Reagents

Betamethasone 17-Propionate is a compound used to study its effects on endotoxin-induced uveitis in rats. It has the activity of inhibiting the infiltration of cells into the aqueous humor in endotoxin-induced uveitis by eye drops and systemic administration at a certain dose. However, its inhibitory effect is relatively weak compared with some other compounds. At the same time, the dose for systemic administration is 1mg/kg. In addition, Betamethasone 17-Propionate has a weaker inhibitory effect on the release of IL-8 from rat peritoneal exudate cells in an in vitro interleukin-8 (IL-8) release assay than betamethasone. Moreover, the simultaneous addition of betamethasone dipropionate and betamethasone 17-Propionate reduces the inhibitory effect of betamethasone on cell infiltration and IL-1β gene expression.

HY-159669

Stercobilin hydrochloride (mixture of isomers)

Cell Assay Reagents

Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a K_i of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .

Cat. No.	Product Name	Target	Research Area

HY-P3042

Chymostatin	SARS-CoV Virus Protease NF-κB Interleukin Related	Inflammation/Immunology
Chymostatin is a SARS-CoV-2 M ^pro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines (IL-1β and IL-6) and HMGB1. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer .

HY-P3211

Nangibotide 4 Publications Verification LR12	TREM receptor NF-κB NOD-like Receptor (NLR) Interleukin Related Apoptosis	Cardiovascular Disease Inflammation/Immunology
Nangibotide (LR12) is a synthetic peptide and TREM-1 receptor inhibitor. Nangibotide inhibits NF-κB and NLRP3 inflammasome activation and reduces the release of pro-inflammatory factors (such as *IL-1β, IL-8). Nangibotide inhibits* Apoptosis. Nangibotide reduces excessive inflammatory responses and protects tissues (liver, lung) from damage. Nangibotide can be used in the researches for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure .

HY-P3211A

Nangibotide TFA 4 Publications Verification LR12 TFA	TREM receptor NF-κB NOD-like Receptor (NLR) Interleukin Related Apoptosis	Cardiovascular Disease Inflammation/Immunology
Nangibotide TFA (LR12 TFA) is a synthetic peptide and TREM-1 receptor inhibitor. Nangibotide TFA inhibits NF-κB and NLRP3 inflammasome activation and reduces the release of pro-inflammatory factors (such as *IL-1β, IL-8). Nangibotide TFA inhibits* Apoptosis. Nangibotide TFA reduces excessive inflammatory responses and protects tissues (liver, lung) from damage. Nangibotide TFA can be used in the researches for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure .

HY-P11296

LLVK	IKK NF-κB	Inflammation/Immunology
LLVK is a selective IκB phosphorylation inhibitor. LLVK reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α). LLVK is promising for research of inflammatory bowel disease and rheumatoid arthritis .

HY-W650842

Boc-Asp(OBzl)-CMK	Caspase	Cancer
Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein .

HY-P5890

YVAD-CHO	Interleukin Related Caspase	Neurological Disease Inflammation/Immunology
YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (K_i: 0.76 nM). YVAD-CHO inhibits mature IL-1β production. YVAD-CHO partially delays motoneurone death in lesioned facial nerve mice .

HY-P11296A

LLVK TFA	IKK NF-κB	Inflammation/Immunology
LLVK TFA is a selective IκB phosphorylation inhibitor. LLVK TFA reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α). LLVK TFA is promising for research of inflammatory bowel disease and rheumatoid arthritis .

HY-P5890A

YVAD-CHO TFA	Caspase Interleukin Related	Neurological Disease Inflammation/Immunology
YVAD-CHO TFA is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (K_i: 0.76 nM). YVAD-CHO TFA inhibits mature IL-1β production. YVAD-CHO TFA partially delays motoneurone death in lesioned facial nerve mice .

HY-P10796

YARA peptide	MAPKAPK2 (MK2)	Inflammation/Immunology
YARA peptide, a cell-penetrating peptide, is a MK2 inhibitor. YARA-loaded nanoparticles decreases the levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α) in an ex vivo skin culture model. YARA peptide is promising for research of atopic dermatitis (AD) .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-P10935

Amilo-5MER 5-MP	Amyloid-β Interleukin Related	Inflammation/Immunology
Amilo-5MER (5-MP) is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER is promising for research of autoimmune diseases and chronic inflammatory diseases .

HY-P10935A

Amilo-5MER TFA 5-MP TFA	Amyloid-β Interleukin Related	Inflammation/Immunology
Amilo-5MER (5-MP) TFA is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER TFA specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER TFA reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER TFA is promising for research of autoimmune diseases and chronic inflammatory diseases .

HY-125083

Lys-D-Pro-Thr	Interleukin Related	Metabolic Disease
Lys-D-Pro-Thr, an IL-1beta analogue (Positions 193-195), is a potent IL-1 inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-P99721

Lutikizumab ABT-981	Interleukin Related	Inflammation/Immunology
Lutikizumab (ABT-981) is an anti-IL-1α and *IL-1β* dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis .

HY-P990781

Suciraslimab SM03	CD22 NOD-like Receptor (NLR) Interleukin Related Integrin	Neurological Disease Inflammation/Immunology
Suciraslimab (SM03) is an anti-human CD22 monoclonal antibody. Suciraslimab inhibits NLRP3 and ASC signaling. Suciraslimab suppresses cytokine (IL-1β, IL-12, IL-23) secretion and α4 integrin expression. Suciraslimab improves working memory and neuroinflammation . Suciraslimab isotype control product: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99111

Golimumab CNTO-148	TNF Receptor Apoptosis Interleukin Related Caspase	Inflammation/Immunology Cancer
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research .

HY-P99555

Tomaralimab OPN-305	Toll-like Receptor (TLR) MyD88 NOD-like Receptor (NLR) Tau Protein Interleukin Related	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Tomaralimab (OPN-305) is a humanized anti-TLR2 IgG4 monoclonal antibody. Tomaralimab inhibits TLR2, MyD88, NLRP3, and reduces pro-inflammatory cytokine (IL-1β, IL-6, IL-8) production. Tomaralimab reduces tau pathology. Tomaralimab improves cognition, atopic dermatitis. Tomaralimab has anticancer effects on pancreatic ductal adenocarcinoma. Tomaralimab is being studied in myelodysplastic syndrome (MDS), atopic dermatitis, pancreatic ductal adenocarcinoma, Alzheimer's disease, and myocardial ischemia/reperfusion injury .

HY-P991670

Abdakibart	Interleukin Related	Inflammation/Immunology
Abdakibart is a humanized IgG4 monoclonal antibody inhibitor targeting *IL-1β*. Abdakibart can be used for inflammatory disease like type 2 diabetes research .

HY-P991269

LY2189102	Interleukin Related	Metabolic Disease
LY2189102 is a humanized monoclonal antibody inhibitor targeting interleukin-1β (IL-1β). LY2189102 is promising for research of type 2 diabetes .

HY-P990252

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)	Notch Interleukin Related NF-κB VEGFR FGFR NO Synthase	Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the DLL4-Notch signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors *(IL-1β, iNOS, IL-6)* levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and IL-17A production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0604

Ginsenoside Rh1 4 Publications Verification Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae	Interleukin Related PPAR TNF Receptor Endogenous Metabolite
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and *IL-1β*.

HY-N0042

Ginsenoside Rc Panaxoside Rc	Panax ginseng C. A. Meyer Triterpenes Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	GABA Receptor TNF Receptor Interleukin Related
Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptor_A (GABA_A)-mediated ion channel currents (I_GABA). Ginsenoside Rc inhibits the expression of TNF-α and *IL-1β*.

HY-N3552

Catalposide	Other Terpenoids Catalpa ovata G. Don Monophenols Classification of Application Fields Terpenoids Source classification Phenols Bignoniaceae Plants Inflammation/Immunology Disease Research Fields	NF-κB
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

HY-N0722

Neochlorogenic acid 2 Publications Verification trans-5-O-Caffeoylquinic acid	Caprifoliaceae Classification of Application Fields Simple Phenylpropanols Lonicera japonica Thunb. Source classification Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	NF-κB Interleukin Related TNF Receptor COX
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and *IL-1β. Neochlorogenic acid suppresses iNOS and COX-2* protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-N8304

Shegansu B (+)-Shegansu B; Parvifolol D	Source classification Gnetum parvifolium (Warb.) C. Y. Cheng ex Chun Phenols Polyphenols Gnetaceae Plants	Interleukin Related
Shegansu B is an inhibitor of *IL-1β. Shegansu B 6 inhibits* IL-1β expression on LPS-induced THP-1 cells with 64.74% inhibition. Shegansu B has anti-inflammatory activity .

HY-N13262

Dactyllactone A	Alkaloids Microorganisms Source classification Isoquinoline Alkaloids	Interleukin Related
Dactyllactone A is an isoquinoline alkaloid that can be isolated from Dactylicapnos scandens. Dactyllactone A shows anti-inflammatory activity. Dactyllactone A inhibits the expression of IL-1β and PGE2 .

HY-N15305

Ferolin	Other Terpenoids Terpenoids Apiaceae Source classification Plants Ferula lapidosa Korovin	FXR
Ferolin is the agonist for farnesoid X receptor (FXR) with an EC₅₀ of 0.56 µM. Ferolin inhibits the expression of inflammatory genes (such as iNOS, IL-1β and TNFα) upon the FXR activation .

HY-126414

Methylenedihydrotanshinquinone	Calea platylepis Terpenoids Labiatae Diterpenoids Plants	Others
Methylenedihydrotanshinquinone is a natural product that can be isolated from the dried root of S. miltiorrhiza. Methylenedihydrotanshinquinone has anti-inflammatory effect by inhibiting expression of TNF-α, IL-1β, and IL-8 .

HY-N0604R

Ginsenoside Rh1 (Standard) Prosapogenin A2 (Standard); Sanchinoside B2 (Standard); Sanchinoside Rh1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae	Interleukin Related Reference Standards PPAR TNF Receptor Endogenous Metabolite
Ginsenoside Rh1 (Standard) is the analytical standard of Ginsenoside Rh1. This product is intended for research and analytical applications. Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.

HY-N15226

Butyrolactone Ia	Microorganisms Source classification Phenols	NO Synthase Interleukin Related Autophagy
Butyrolactone Ia is the inhibitor for the NO production with an IC₅₀ of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity .

HY-N15566

Theleganbanin D	Microorganisms Source classification Phenols Polyphenols	Drug Derivative
Theleganbanin D is a p-terphenyl derivative found in the Thelephora ganbajun. Theleganbanin D inhibits TNF-α, IL-6, and IL-1β production in LPS-induced BV-2 microglial cells. Theleganbanin D is promising for research of neurodegenerative diseases .

HY-N0633

Muscone 4 Publications Verification	Cardiovascular Disease Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	P-glycoprotein Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate .

HY-N0042R

Ginsenoside Rc (Standard) Panaxoside Rc (Standard)	Panax ginseng C. A. Meyer Triterpenes Terpenoids Source classification Plants Araliaceae	Reference Standards GABA Receptor TNF Receptor Interleukin Related
Ginsenoside Rc (Standard) is the analytical standard of Ginsenoside Rc. This product is intended for research and analytical applications. Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.

HY-129113

α-Chaconine	Alkaloids Piperidine Alkaloids Zea mays L. Pyrrole Alkaloids Classification of Application Fields Gramineae Source classification Plants Inflammation/Immunology Disease Research Fields	COX
α-Chaconine inhibits the expressions of COX-2, *IL-1β, IL-6, and TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N15564

Theleganbanin B	Microorganisms Source classification Phenols Polyphenols	Drug Derivative
Theleganbanin B is a p-terphenyl derivative found in the Thelephora ganbajun. Theleganbanin B inhibits TNF-α, IL-6, and IL-1β production in LPS-induced BV-2 microglial cells. Theleganbanin B inhibits the phosphorylation of JAK2/STAT3. Theleganbanin B is promising for research of neurodegenerative diseases .

HY-134000

Emodic acid NSC624610	Quinones Human Gut Microbiota Metabolites Microorganisms Leguminosae Cercis chinensis Bunge Anthraquinones Source classification Plants Endogenous metabolite	p38 MAPK NF-κB ERK JNK VEGFR MMP
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells .

HY-N12235

Sarglaroids F	Ketones, Aldehydes, Acids Source classification Sarcandra glabra (Thunb.) Nakai Chloranthaceae Plants	Caspase
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells .

HY-112642

9-Methoxycanthin-6-one	Alkaloids other families Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer	TNF Receptor
9-Methoxycanthin-6-one, a canthin-6-one alkaloid, is present in intact plant parts and in callus tissues of different explants. 9-Methoxycanthin-6-one shows anti-tumor activity, inhibits LPS-induced TNF-α and IL-1β .

HY-N0722A

(Z)-Neochlorogenic acid cis-5-O-Caffeoylquinic acid	Structural Classification Caprifoliaceae Lonicera periclymenum L. Source classification Phenols Polyphenols Plants	Drug Derivative
(Z)-Neochlorogenic acid is the z-isomer of Neochlorogenic acid (HY-N0722). Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and *IL-1β. Neochlorogenic acid suppresses iNOS and COX-2* protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation .

HY-N0722R

Neochlorogenic acid (Standard) trans-5-O-Caffeoylquinic acid (Standard)	Caprifoliaceae Simple Phenylpropanols Lonicera japonica Thunb. Source classification Phenols Polyphenols Phenylpropanoids Plants	Reference Standards NF-κB Interleukin Related TNF Receptor COX
Neochlorogenic acid (Standard) is the analytical standard of Neochlorogenic acid. This product is intended for research and analytical applications. Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-N15307

Trigraecum	Dalbergia cochinchinensis Flavonoids Flavonones Papilionaceae Source classification Plants	Interleukin Related TNF Receptor
Trigraecum is a flavonoid compound found in Dracaena steudneri and Dalbergia cochinchinensis, exhibiting anti-inflammatory activity. It can inhibit the LPS (HY-D1056)-induced production of *IL-1β, IL-2, GM-CSF, and TNF-α* in human peripheral blood mononuclear cells. Trigraecum holds promise for research on inflammatory diseases .

HY-N8371

Shizukaol B	Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants Chloranthus henryi Hemsl.	NO Synthase COX Interleukin Related TNF Receptor
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and **IL-1β expression .**

HY-W015546R

β-N-methylamino-L-alanine hydrochloride (Standard) BMAA hydrochloride (Standard)	Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial Reference Standards mGluR PKC
Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

HY-N0633R

Muscone (Standard)	Animals Ketones, Aldehydes, Acids Source classification	P-glycoprotein Reference Standards Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)
Muscone (Standard) is the analytical standard of Muscone. This product is intended for research and analytical applications. Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate .

HY-N0936R

Coixol (Standard) 6-Methoxy-2-benzoxazolinone (Standard); 6-MBOA (Standard)	Ketones, Aldehydes, Acids Gramineae Marine natural products Source classification Coix lacryma-jobi Linn. Plants	Others
Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level .

HY-N0283

Diacerein 5 Publications Verification Diacerhein; Diacetylrhein	Rumex crispus Linn. Quinones Classification of Application Fields Anthraquinones Polygonaceae Source classification Plants Inflammation/Immunology Disease Research Fields	Interleukin Related Calcium Channel
Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research .

HY-N0405

Orientin 4 Publications Verification	Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	TNF Receptor Interleukin Related
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, *IL-1β* and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N0218

Benzoylmesaconine 1 Publications Verification Mesaconine 14-benzoate	Alkaloids Classification of Application Fields Other Alkaloids Ranunculaceae Source classification Aconitum carmichaeli Debx. Plants Inflammation/Immunology Disease Research Fields	NF-κB Interleukin Related
Benzoylmesaconine is a monoester-type alkaloid and is the most abundant component of Wutou decoction, which is widely used in China for rheumatoid arthritis. Benzoylmesaconine exhibits potent anti-inflammatory properties by inhibiting NF-κB. Benzoylmesaconine can suppress NLRP3 inflammasome activation by inhibiting *IL-1β* secretion and GSDMD-N protein expression. Benzoylmesaconine reduces intracellular K ⁺ efflux and disrupts NLRP3 inflammasome assembly .

HY-B1092A

Gluconate sodium D-Gluconic acid sodium salt; Sodium D-gluconate; D-Gluconate sodium salt	other families Classification of Application Fields Anti-aging Source classification Other Diseases Plants Endogenous metabolite Disease Research Fields Saccharides Monosaccharides	Endogenous Metabolite NO Synthase Interleukin Related ERK
Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury .

HY-N8563

Masticadienonic acid	Triterpenes Terpenoids Source classification Pistacia terebinthus L. Plants Anacardiaceae	p38 MAPK NF-κB Keap1-Nrf2
Masticadienonic acid is an orally active and selective inhibitor of MAPK (p38, ERK, JNK) and NF-κB pathways and an agonist of the Nrf2 pathway. Masticadienonic acid reduces the release of pro-inflammatory cytokines such as TNFα, IL-1β, and IL-6, restores the expression of intestinal tight junction proteins (ZO-1, occludin), and modulates gut microbiota. Masticadienonic acid is promising for research of inflammatory bowel disease .

HY-N5083

Saponarin 1 Publications Verification	Flavonoids Classification of Application Fields Flavones Dipsacaceae Dipsacus sativus (Linn.) Honck. Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	PERK NF-κB p38 MAPK AMPK Interleukin Related COX
Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-κB and MAPK phosphorylation and activates AMPK. Saponarin reduces *IL-1β* and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders .

HY-129113R

α-?Chaconine (Standard)	Alkaloids Piperidine Alkaloids Zea mays L. Pyrrole Alkaloids Gramineae Source classification Plants	Reference Standards COX
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N0619

Mulberroside A 4 Publications Verification	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Inflammation/Immunology Disease Research Fields	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-N7652

Terminolic acid	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Bacterial Interleukin Related
Terminolic acid is a pentacyclic triterpene glycoside and antibacterial agent. Terminolic acid can be isolated from Combretum racemosum. Terminolic acid inhibits proinflammatory cytokines by binding to the receptor active sites of *IL-1β* and IL-6. Terminolic acid reduces IL-8. Terminolic acid has antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis with MICs ranging from 64 to 256 μg/mL. Terminolic acid is used in colon cancer research .

HY-107208

Procyanidol B4 1 Publications Verification (-)-Procyanidin B4	Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Biflavones Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species (ROS) COX Interleukin Related NO Synthase
Procyanidol B4 ((-)-Procyanidin B4) is an orally active polyphenol found in Q.gilva. Procyanidol B4 exerts antioxidant activity by scavenging DPPH (HY-112053) (IC₅₀: 12.15 μM) and Nitro blue tetrazolium chloride (NBT) (HY-15925) (IC₅₀: 8.67 μM). Procyanidol B4 exhibits anti-inflammatory activity by inhibiting the expression of COX-2 and IL-1β and iNOS .

HY-B1092

Gluconate Calcium Calcium D-gluconate; Gluconic acid hemicalcium salt	Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Saccharides Monosaccharides	NO Synthase Endogenous Metabolite Interleukin Related ERK
Gluconate (D-Gluconic acid) Calcium is an orally active glucose derivative. Gluconate Calcium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate Calcium inhibits ERK phosphorylation. Gluconate Calcium has antioxidant and antiplatelet activation activities. Gluconate Calcium has antitumor activity against colorectal cancer. Gluconate Calcium improves osteoarthritis, intestinal damage and acute lung injury .

HY-N2115

Araloside A 1 Publications Verification Chikusetsusaponin IV	Cardiovascular Disease Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Renin Apoptosis Bcl-2 Family Interleukin Related
Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC₅₀ of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis .

HY-N14780

Pochonin D (+)-Pochonin D	Natural Products Microorganisms Source classification	HSP Interleukin Related Enterovirus
Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affecting the homeostasis, folding, and assembly processes of viral proteins, reducing the replication ability of the virus. Pochonin D reduces the infiltration of inflammatory cells and the secretion of inflammatory cytokines such as TNF-α and IL-1β, alleviating the inflammatory response. Pochonin D is promising for research of Human rhinoviruses (HRV) infections and cancers .

HY-N0405R

Orientin (Standard)	Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Reference Standards TNF Receptor Interleukin Related
Orientin (Standard) is the analytical standard of Orientin. This product is intended for research and analytical applications. Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N6636

Valencene 1 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Cyperaceae Cyperus rotundus L. Plants Inflammation/Immunology Disease Research Fields	NF-κB Interleukin Related
Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model .

HY-N0619A

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-N15347

Talaromyketide B	Natural Products Microorganisms Source classification	NF-κB p38 MAPK Interleukin Related TNF Receptor NO Synthase COX
Talaromyketide B is a polyketide compound with anti-inflammatory activity, discovered in the soil bacterium Talaromyces sp. KYS-41. Talaromyketide B inhibits the activation of the NF-κB and MAPK signaling pathways and dose-dependently suppresses pro-inflammatory cytokines, such as IL-1β, IL-6, IL-10, and TNF-α, as well as the transcriptional activity of inflammatory mediators, including iNOS and COX-2. Talaromyketide B holds potential for research in the fields of immunity and inflammatory diseases .

HY-N2115R

Araloside A (Standard) Chikusetsusaponin IV (Standard)	Triterpenes other families Terpenoids Source classification Plants Araliaceae	Reference Standards Renin Apoptosis Bcl-2 Family Interleukin Related
Araloside A (Standard) (Chikusetsusaponin IV (Standard)), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A (Standard) shows low-renin-inhibitory activity with an IC₅₀ of 77.4 μM. Araloside A (Standard) can inhibit cell proliferation and induce apoptosis. Araloside A (Standard) suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A (Standard) can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis .

HY-N11768

4-Methoxylonchocarpin	Monophenols Source classification Phenols Plants Moraceae Dorstenia mannii Hook.f.	NF-κB Interleukin Related Toll-like Receptor (TLR)
4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model .

HY-W011978

N-Acetyl-L-tryptophan	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of *IL-1β* and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-N0619R

Mulberroside A (Standard)	Stilbenes Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	Reference Standards TNF Receptor Interleukin Related Tyrosinase
Mulberroside A (Standard) is the analytical standard of Mulberroside A. This product is intended for research and analytical applications. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-N0433

Astragaloside II 1 Publications Verification Astrasieversianin VIII	Triterpenes Classification of Application Fields Leguminosae Terpenoids Source classification Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields	Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB
Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, *IL-1β), HIF-α, p-p65, p-IκB* and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .

HY-N5083R

Saponarin (Standard)	Flavonoids Flavones Dipsacaceae Dipsacus sativus (Linn.) Honck. Source classification Phenols Polyphenols Plants	Reference Standards PERK NF-κB p38 MAPK AMPK Interleukin Related COX
Saponarin (Standard) is the analytical standard of Saponarin (HY-N5083). This product is intended for research and analytical applications. Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-κB and MAPK phosphorylation and activates AMPK. Saponarin reduces *IL-1β* and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders .

HY-N0890

Tubeimoside I 4 Publications Verification Tubeimoside-1; Lobatoside-H	Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet Disease Research Fields Cancer	HSP NF-κB p38 MAPK Akt Autophagy Interleukin Related VEGFR
Tubeimoside I is an orally active HSPD1 inhibitor. Tubeimoside I inhibits NF-κB, MAPK, as well as regulates eNOS-VEGF. Tubeimoside I induces cytoprotective Autophagy via an Akt-mediated pathway. Tubeimoside I inhibits proinflammatory cytokine (IL-6 and *IL-1β*) production. Tubeimoside I exhibits anti-inflammatory activities. Tubeimoside I promotes angiogenesis and improves sepsis symptoms. Tubeimoside I is used in the research of inflammatory diseases, various cancers, sepsis and ischemic diseases .

HY-N16450

Cnidilide	Natural Products Source classification Plants	NO Synthase COX Interleukin Related TNF Receptor p38 MAPK JNK NF-κB
Cnidilide is a natural product of alkylphthalein. Cnidilide can be isolated from the rhizomes of Cnidium officinale. Cnidilide reduces the production of NO and PGE2 by inhibiting the expression of iNOS and COX-2 induced by LPS (HY-D1056). Cnidilide can inhibit pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Cnidilide can specifically inhibit the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Cnidilide blocks the signaling pathway by inhibiting the transcriptional activity of AP-1 and NF-κB. can be used for research on inflammation conditions .

Cat. No.	Product Name	Chemical Structure

HY-W768336

Gluconate-13C6 sodium

Gluconate sodium- ¹³C₆ (D-Gluconic acid sodium salt- ¹³C₆) is the ¹³C-labeled Gluconate sodium (HY-B1092A). Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury .

HY-B1092AS

Gluconate-1-13C sodium

Gluconate-1- ¹³C (D-Gluconic acid-1- ¹³C) sodium is the ¹³C labeled Gluconate sodium (HY-B1092A). Gluconate (D-Gluconic acid) sodium is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury .

HY-B0678S

Metaxalone-d3

Metaxalone-d₃ is the deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-19717S

DCVC-13C3,15N
DCVC- ¹³C₃, ¹⁵N is ¹⁵N and ¹³C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures .

HY-B0898S

Ceftiofur-d3 sodium

Ceftiofur-d₃ sodium is deuterium labeled Ceftiofur sodium (HY-B0898). Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .

HY-W753956

Iminostilbene-d10

Iminostilbene-d₁₀ is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases .

HY-B0678S1

Metaxalone-d6

Metaxalone-d₆ is deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-N0001S2

(-)-Epicatechin-13C3
(-)-Epicatechin- ¹³C₃ ((-)-Epicatechol- ¹³C₃) is ¹³C labeled (-)-Epicatechin. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N0001S

(±)-Epicatechin-13C3
(±)-Epicatechin- ¹³C₃ is the ¹³C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB .

HY-N2037AS1

Higenamine-d4-1 hydrochloride

Higenamine-d₄-1 (Norcoclaurine-d₄-1) hydrochloride is deuterium labeled Higenamine (hydrochloride). Higenamine hydrochloride is a selective LSD1 inhibitor (IC₅₀=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .

Cat. No.	Product Name		Classification

HY-130252

YQ128 1 Publications Verification		Alkynes
YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC₅₀ of 0.30 μM. YQ128 significantly and selectively suppresses the production of *IL-1β*, but not TNF-α, and it can cross the BBB to reach the CNS. YQ128 has anti-inflammatory activity . YQ128 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-172451

MC4762		Alkynes
MC4762 is an inhibitor of NOX2 and MAOB, with IC₅₀ values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, *IL-1β, and IL-6* .

HY-175484

PDIA1-IN-1		Alkynes
PDIA1-IN-1 is a protein disulfide isomerase 1 (PDIA1) inhibitor. PDIA1-IN-1 can inhibit NLRP3 inflammasome assembly and activity, with an IC₅₀ value of 1 μM. PDIA1-IN-1 can reduce IL-1β secretion. PDIA1-IN-1 can be used for the researches of inflammation and neurological disease .

HY-173115

15-LOX-IN-2		Alkynes
15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, *IL-1β* and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases .

Cat. No.	Product Name		Classification

HY-132591

Inclisiran 5+ Cited Publications ALN-PCSsc		siRNAs siRNA drugs
Inclisiran is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran inhibits the transcription of PCSK9. Inclisiran inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, *IL-1β, and IL-18*. Inclisiran has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran can be used in researches of hyperlipidemia and cardiovascular disease (CVD) .

HY-132591A

Inclisiran sodium 5+ Cited Publications ALN-PCSsc sodium		siRNAs siRNA drugs
Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran sodium inhibits the transcription of PCSK9. Inclisiran sodium inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, *IL-1β, and IL-18*. Inclisiran sodium has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran sodium can be used in researches of hyperlipidemia and cardiovascular disease (CVD) .

HY-N0171

Beta-Sitosterol (purity>80%) Maximum Cited Publications 15 Publications Verification		Cholesterol
Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, *IL-1β, and NF-κB p65* and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks