Search Result

Results for "

( )-JQ1 PA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (12) Acyltransferase (1) ADC Linker (1) ADC Payload (1) Adrenergic Receptor (7) Akt (1) AMPK (1) Amylases (1) Angiotensin Receptor (2) Antibiotic (10) Apoptosis (6) Atg8/LC3 (1) ATP Synthase (4) Autophagy (2) Bacterial (31) Biochemical Assay Reagents (16) Calcium Channel (2) Cholinesterase (ChE) (2) Complement System (2) COX (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (4) Dopamine Receptor (5) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (4) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (7) Endogenous Metabolite (22) Endothelin Receptor (4) Ephrin Receptor (1) Epigenetic Reader Domain (41) ERK (1) Estrogen Receptor/ERR (4) FAAH (1) Factor Xa (1) FAK (1) Fluorescent Dye (4) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (1) GCGR (2) GLUT (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (12) Histone Methyltransferase (1) HSP (17) iGluR (1) Influenza Virus (12) Insecticide (1) Insulin Receptor (1) IRAK (1) Isotope-Labeled Compounds (26) JNK (2) Leukotriene Receptor (2) Ligands for E3 Ligase (4) Ligands for Target Protein for PROTAC (1) Liposome (4) LPL Receptor (4) mAChR (7) Mitochondrial Metabolism (1) MMP (1) Molecular Glues (3) mTOR (2) nAChR (1) Natriuretic Peptide Receptor (NPR) (1) Neurokinin Receptor (3) Neuromedin U Receptor (NMUR) (2) Neuropeptide S Receptor (1) Opioid Receptor (3) Oxytocin Receptor (1) P2Y Receptor (2) p62 (1) PACAP Receptor (3) PAI-1 (4) Pantetheinase (1) PD-1/PD-L1 (1) PDGFR (1) Phosphatase (2) Photosensitizer (2) PKC (1) Potassium Channel (1) Prostaglandin Receptor (2) PROTAC Linkers (3) PROTACs (24) Proteasome (1) RAR/RXR (2) Ras (1) Reactive Oxygen Species (ROS) (6) Reference Standards (13) Ribosomal S6 Kinase (RSK) (2) ROS Kinase (1) SARS-CoV (1) Ser/Thr Protease (2) Small Interfering RNA (siRNA) (3) SNIPERs (1) Sodium Channel (1) STAT (1) Target Protein Ligand-Linker Conjugates (3) Thrombin (4) Toll-like Receptor (TLR) (1) Vasopressin Receptor (2) VEGFR (1) Virus Protease (2) YAP (1)
By Research Areas:	Cancer (102) Cardiovascular Disease (32) Endocrinology (12) Infection (45) Inflammation/Immunology (24) Metabolic Disease (33) Neurological Disease (52)
Click Chemistry:	ADC Synthesis (1) TCO (1) Azide (2) Alkynes (1)
Oligonucleotides:	Nucleotide Analogs (2) Rat Pre-designed siRNA Sets (1) Phospholipids (6) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

286

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112789

*(+)-JQ1* PA** 1 Publications Verification	Epigenetic Reader Domain	Cancer
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC₅₀ of 10.4 nM. (+)-JQ1 PA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13030

(+)-JQ-1 Maximum Cited Publications 276 Publications Verification JQ1	Epigenetic Reader Domain Autophagy Ligands for Target Protein for PROTAC	Cancer
(+)-JQ-1 (JQ1), a chemical probe, is a potent, specific, and reversible BET bromodomain inhibitor, with IC₅₀s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)) ^[1]. (+)-JQ-1 also activates autophagy .

HY-78695

JQ-1 (carboxylic acid) 5+ Cited Publications	Epigenetic Reader Domain PD-1/PD-L1	Cancer
JQ-1 carboxylic acid, a (+)-JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4.

HY-148864

JQ1-TCO	Epigenetic Reader Domain	Cancer
JQ1-TCO is the double bond E configuration of JQ1-TCO (HY-148864A). JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo ^[1] .

HY-169150

JQ-1 carboxylic acid-PEG3-C2-NH2	E3 Ligase Ligand-Linker Conjugates	Cancer
JQ-1 carboxylic acid-PEG3-C2-NH2 is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT ^[1].

HY-145667

Biotinylated-JQ1 1 Publications Verification Biotin-JQ1	Epigenetic Reader Domain	Cancer
Biotinylated-JQ1 (Biotin-JQ1) is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC₅₀ of 0.4 μM ^[1].

HY-137075

(±)-JQ1	Epigenetic Reader Domain	Cancer
(±)-JQ1 is the racemate of (+)-JQ-1 (HY-13030) ^[1].

HY-169082

JQ-1 (carboxylic acid)-NH-C2-NH-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
JQ-1 (carboxylic acid)-NH-C2-NH-COOH is a conjugate of E3 ligase ligand and linker (E3 Ligase Ligand-Linker Conjugates), which is composed of JQ-1 carboxylic acid (HY-78695) and the corresponding linker: (2-Aminoethyl)carbamic acid (HY-W398806). JQ-1 (carboxylic acid)-NH-C2-NH-COOH can be used as a Cereblon ligand to recruit CRBN protein and as a key intermediate for the synthesis of complete PROTACs molecules ^[1].

HY-161125

*(+)-JQ1-OH*	Drug Metabolite	Others
(+)-JQ1-OH is the major metabolite of (+)-JQ1(HY-13030). (+)-JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC_50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy ^[1].

HY-169150A

JQ-1 carboxylic acid-PEG3-C2-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
JQ-1 carboxylic acid-PEG3-C2-NH2 (hydrochloride) is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT ^[1].

HY-13030A

*(R)-(-)-JQ1* Enantiomer** 10+ Cited Publications	Epigenetic Reader Domain	Cancer
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.

HY-148864A

*(Z)-JQ1-TCO*	Epigenetic Reader Domain	Cancer
JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo ^[1] .

HY-172126

JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222	Target Protein Ligand-Linker Conjugates Epigenetic Reader Domain	Cancer
JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a ligand for BRD4, and a PROTACs linker that can be used in the synthesis of PROTAC BRD4 Degrader-29 (HY-172124) ^[1].

HY-131633A

*(+)-JQ-1-aldehyde*	Epigenetic Reader Domain	Cancer
(+)-JQ-1-aldehyde is the aldehyde form of (+)-JQ1. (+)-JQ-1-aldehyde can be uesd as a precursor to synthesize PROTACs, which targets BET bromodomains ^[1].

HY-129917

KB02-JQ1 4 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1 ^[1].

HY-176391

Ad-JQ1	Target Protein Ligand-Linker Conjugates Epigenetic Reader Domain	Cancer
Ad-JQ1 (Compound 16) is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-176390), which recruits E3 ligases. Ad-JQ1 can be used for synthesis of PROTAC β-NF-JQ1 (HY-130256) ^[1].

HY-176724

ZnPc-O3-JQ1	Epigenetic Reader Domain Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase	Cancer
ZnPc-O3-JQ1 is a light-triggered BRD4 degrader. Under illumination, ZnPc-O3-JQ1 generates reactive oxygen species (ROS) that degrades BRD4. The degradation of BRD4 results in downregulation of *HIF-1α, thereby counteracting the photodynamic therapy (PDT) resistance induced by tumor hypoxia. ZnPc-O3-JQ1* exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 consists of three parts: BRD4 ligand (HY-78695); Linker (HY-W040165); Photosensitizer (HY-176725) ^[1].

HY-178510

JQ1-S(GlcNAc)Cq	PROTACs Epigenetic Reader Domain	Cancer
JQ1-S(GlcNAc)Cq is a sugar-coated BRD4 PROTAC degrader. JQ1-S(GlcNAc)Cq can inhibit the formation of the ternary complex between CRBN and BRD4(BD1/BD2). JQ1-S(GlcNAc)Cq can be used for the research of cancer ^[1]. (Structure Note: Pink: BRD4 ligand (HY-78695); Blue: CRBN ligand (HY-178514); Black: linker (HY-W105727); BRD4 ligand-Linker: (HY-178519))

HY-156214

NICE-01 AP1867-PEG2-JQ1; AP-PEG2-JQ1	Epigenetic Reader Domain	Others
NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that bind to proteins in separate cellular compartments that can induce nuclear import of cytosolic cargoes, using nuclear-localized bromodomain-containing protein 4 (BRD4) as a “carrier” for co-import and nuclear trapping of cytosolic proteins ^[1].

HY-147046

*ET-JQ1-OH*	Epigenetic Reader Domain	Cancer
ET-JQ1-OH is an allele-specific BET inhibitor ^[1].

HY-130256

β-NF-JQ1	PROTACs Epigenetic Reader Domain	Cancer
β-NF-JQ1 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity ^[1].

HY-153574

BI01826025 PArg-JQ1	PROTACs Epigenetic Reader Domain	Infection
BI01826025 (pArg-JQ1) is a bromodomain1 of BRDT (BRDT_BD1) PROTAC degrader. BI01826025 can be used for testing the regulatory effect of ClpC2 on the ClpC1P1P2 protease ^[1].

HY-153573

SRG-II-19F dCym-JQ1	PROTACs Epigenetic Reader Domain	Infection
SRG-II-19F (dCym-JQ1) is a bromodomain1 of BRDT (BRDT_BD1) PROTAC degrader. SRG-II-19F can be used for testing the regulatory effect of ClpC2 on the ClpC1P1P2 protease ^[1].

HY-174995

JQ-1-Azidopropylamine	Target Protein Ligand-Linker Conjugates Epigenetic Reader Domain	Cancer
JQ-1-Azidopropylamine is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975) ^[1].

HY-176725

ZnPcPs	Photosensitizer Reactive Oxygen Species (ROS)	Cancer
ZnPcPs is a photosensitizer that generates ROS. ZnPcPs can be used to synthesize the photo-activated BRD4 degrader pZnPc-O3-JQ1 (HY-176724) ^[1].

HY-P10352

Pediocin PA 1	Bacterial	Infection
Pediocin PA-1 is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 can be used as a food biopreservative ^[1].

HY-112544

IK1 inhibitor PA-6 1 Publications Verification PA-6	Potassium Channel	Cardiovascular Disease
IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent *I_K1* (K_IR2.x ion-channel-carried inward rectifier current) inhibitor, with IC₅₀ values of 12-15 nM for human and mouse K_IR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates K_IR2.1 protein expression and induces intracellular K_IR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia ^[1] .

HY-P10352A

Pediocin PA 1 TFA	Bacterial	Infection
Pediocin PA-1 TFA is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 TFA can be used as a food biopreservative ^[1].

HY-129421

PA-9	PACAP Receptor	Neurological Disease Inflammation/Immunology
PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC₅₀ of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain ^[1].

HY-10844

Pretomanid 5+ Cited Publications PA-824; (S)-PA 824	Bacterial Antibiotic	Infection Cancer
Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-133529

PA-8 2 Publications Verification	PACAP Receptor	Neurological Disease Inflammation/Immunology
PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in *PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC₅₀* of 2 nM ^[1] .

HY-111823

VH032 thiol VHL ligand 6	Ligands for E3 Ligase	Cancer
VH032 thiol (VHL ligand 6) is a VHL ligand, which binds to pan-BET inhibitor JQ1 via a linker to form PROTAC ^[1].

HY-156774

CCW 28-3	PROTACs Epigenetic Reader Domain	Others
CCW 28-3 is a PROTAC-based BRD4 degrader in a proteasome- and RNF4-dependent manner (Pink: JQ-1 (carboxylic acid) (HY-78695); Black: linker (HY-170384); Blue: RNF4 ligand CCW16 (HY-143346)) ^[1].

HY-170453

iHAC	Epigenetic Reader Domain	Cancer
iHAC is an inhibitor HSP90-anchoring chimera, that covalently binds BRD4 ligand (+)-JQ-1 to HSP90, and inhibits the proliferation of cancer cells. iHAC activates the anti-tumor immune response, inhibits the recurrence and metastasis of 4T1 breast cancer in mouse models ^[1].

HY-103495

17-PA	GABA Receptor	Neurological Disease
17-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABA ^A receptors ^[1].

HY-100696

PNZ5	Epigenetic Reader Domain	Cancer
PNZ5 is a potent and isoxazole-based pan-BET inhibitor with high selectivity and potency similar to the well-established (+)-JQ1, with a K_D of 5.43 nM for BRD4(1) ^[1].

HY-144767

PA3552-IN-1	Bacterial	Infection
PA3552-IN-1 (compound 15) is an antibiotic adjuvant that restores sensitivity of MDR P. aeruginosa DK2 strain to Polymyxin B. PA3552-IN-1 can reduce PA3552 expression ^[1].

HY-161769

HL435	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
HL435 is a heterobifunctional molecule that degrades BRD4 by linking to JQ1, with DC₅₀ of 11.9 nM and 21.9 nM, in MDA-MB-231 and MCF-7 cells, respectively. HL435 inhibits the proliferation of MDA-MB-231, MCF-7, 22Rv1 and A549, arrests the cell cycle and induces apoptosis. HL435 exhibits antitumor activity in mouse model. (Pink: ligand for target protein JQ-1 (HY-78695); Black: linker (HY-W004640); blue: ligand for E3 ligase HL389 (HY-161770)) ^[1]

HY-10844R

Pretomanid (Standard) PA-824 (Standard); (S)-PA 824 (Standard)	Reference Standards Bacterial Antibiotic	Infection Cancer
Pretomanid (Standard) is the analytical standard of Pretomanid. This product is intended for research and analytical applications. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-169081

QS-57	PROTACs Molecular Glues	Others
QS-57 is a PROTAC targeting BRD4. QS-57 can be used as a 14-3-3 molecular glue. (Red: EN171 (HY-W1005067), black: (2-Aminoethyl) carbamic acid (HY-W398806), Blue: JQ-1 (carboxylic acid) (HY-78695)) ^[1].

HY-125667

PA1 Photoamiloride-1	Sodium Channel	Metabolic Disease
PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC₅₀ values of 4.3nM, 90 nM, and 390 nM, respectively ^[1].

HY-P5981

Chromozym t-PA	Biochemical Assay Reagents	Others
Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration ^[1]

HY-P11091

PA2-GNU7	Bacterial	Infection
PA2-GNU7 is an antimicrobial peptide (AMP). PA2-GNU7 exhibits potent antimicrobial activity with minimal inhibitory concentration (MIC) against P. aeruginosa, E. coli, S. typhimurium, S. aureus, and C. albicans are 2 μM, 1 μM, 2 μM, 2 μM, and 8 μM, respectively. PA2-GNU7 rapidly and selectively kills Pseudomonas aeruginosa without affecting other commensal bacteria. PA2-GNU7 significantly improves survival of mice infected with P. aeruginosa. PA2-GNU7 can be used for the research and development of therapeutic agents against MDR Pseudomonas aeruginosa infections ^[1].

HY-155684

SA-PA	PROTACs VEGFR PDGFR Ephrin Receptor	Cancer
SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-PA is able to selectively degrade VEGFR-2, PDGFR-β and EphB4 proteins in U87 cells. SA-PA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues ^[1].

HY-101838

dBET1 15+ Cited Publications	PROTACs Epigenetic Reader Domain	Cancer
dBET1 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC₅₀ of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker ^[1].

HY-131385

KB02-COOH	Ligands for E3 Ligase	Cancer
KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 (HY-129917) and KB02-SLF (HY-129610) ^[1].

HY-149594

CL-Pa	Pantetheinase	Metabolic Disease
CL-Pa is a chemiluminescent probe suitable for detection of urinary Vanin-1. CL-Pa can be used to detect drug-induced acute kidney injury (AKI) through urinalysis ^[1].

HY-P10827A

PIC1 PA TFA	Complement System	Inflammation/Immunology
PIC1 PA TFA is the trifluoroacetate salt form of PIC1 PA (HY-P10827). PIC1 PA TFA is a 15-amino acid peptide that is a potent PIC1 analog that inhibits classical complement activation ^[1].

HY-162835

PROTAC SMARCA2/4-degrader-28	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-28 (PROTAC 1) is a PROTAC-based partial degrader of SMARCA2 and SMARCA4(Bliue: CRL2 ^VHL ligand (S,R,S)-AHPC (HY-125845); Black: linker (HY-159680); Pink: a SMARCA-BD ligand (+)-JQ-1 (HY-13030)) ^[1].

HY-P11442

Lytx-Pa2a Lycotoxin-PA2a; TBIU041425	Bacterial Toll-like Receptor (TLR)	Inflammation/Immunology
Lytx-Pa2a (Lycotoxin-Pa2a) is a peptide inhibitor against bacterial membranes and TLR4 receptor. Lytx-Pa2a exerts antimicrobial effects via non-competitive disruption of outer/cytoplasmic membranes and suppression of LPS-induced TLR4/NF-κB signaling. Lytx-Pa2a is promising for research of bacterial infection and inflammation-related disease (e.g., sepsis) ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0842

Bevirimat 1 Publications Verification PA-457; MPC-4326; YK FH312	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Myrtaceae Plants Syzygium aromaticum Disease Research Fields	Virus Protease
Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of *HIV-1* viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies ^[1] .

HY-I0508

Phthalic acid 2 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Biochemical Assay Reagents Reactive Oxygen Species (ROS) Estrogen Receptor/ERR
Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers. Phthalic acid exhibits mutagenic effect and causes genetic damage in mammalian germ cells ^[1] .

HY-113845

(+)-Intermedine	Alkaloids Pyrrole Alkaloids Symphytum officinale L. Plants Boraginaceae	Others
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) ^[1].

HY-N6638

Retrorsine 1 Publications Verification	Alkaloids Pyrrole Alkaloids Erinacea anthyllis Link Classification of Application Fields Source classification Metabolic Disease Plants Compositae Disease Research Fields	Others
Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury ^[1] .

HY-N15817

16:0 PA-PEG3-Mannose ammonium	Lipid	Biochemical Assay Reagents
16:0 PA-PEG3-Mannose ammonium is a functionalized lipid.

HY-N15970

18:1-12:0 Biotin PA ammonium	Lipid	Biochemical Assay Reagents
18:1-12:0 Biotin PA ammonium is a biotinylated form of phosphatidic acid that can be conjugated to streptavidin.

HY-N0842R

Bevirimat (Standard) PA-457 (Standard); MPC-4326 (Standard); YK FH312 (Standard)	Triterpenes Terpenoids Source classification Myrtaceae Plants Syzygium aromaticum	Reference Standards Virus Protease
Bevirimat (Standard) is the analytical standard of Bevirimat. This product is intended for research and analytical applications. Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies[1][2][3][4].

HY-I0508R

Phthalic acid (Standard)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Biochemical Assay Reagents Reference Standards Reactive Oxygen Species (ROS) Estrogen Receptor/ERR
Phthalic acid (Standard) is the analytical standard of Phthalic acid. This product is intended for research and analytical applications. Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers. Phthalic acid exhibits mutagenic effect and causes genetic damage in mammalian germ cells ^[1] .

HY-N15109

Phoenistatin	Microorganisms Antibiotics Source classification Other Antibiotics	Others
Phoenistatin is a substance that increases the expression of genes. 3 nM-1000 μM of Phoenistatin causes more than 3 times the gene expression of the PA1-1 promoter ^[1].

HY-N9130

Indicine	Alkaloids Other Alkaloids Source classification Plants Heliotropium amplexicaule Vahl Boraginaceae	Others
Indicine (Compound 3) is an alkaloid. Indicine can reduce pyrrolizine alkaloids (PA) ^[1].

HY-N6638R

Retrorsine (Standard)	Alkaloids Pyrrole Alkaloids Erinacea anthyllis Link Source classification Plants Compositae	Reference Standards Others
Retrorsine (Standard) is the analytical standard of Retrorsine. This product is intended for research and analytical applications. Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury ^[1] .

HY-124058

Jacobine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Plants Compositae Baptisia australis (L.) R. Br. Disease Research Fields	Insecticide
Jacobine?is a pyrrolizidine alkaloid (PA) from Senecio jacobaea ^[1]. Jacobine is active against second instar larvae of thrips .

HY-W013549

6-Aminopenicillanic acid 6-APA	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Drug Metabolite Bacterial
6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses ^[1] .

HY-W013549R

6-Aminopenicillanic acid (Standard) 6-APA (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Drug Metabolite Reference Standards Bacterial
6-Aminopenicillanic acid (Standard) is the analytical standard of 6-Aminopenicillanic acid. This product is intended for research and analytical applications. 6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses ^[1] .

HY-131574

Heliosupine N-oxide	Alkaloids Pyrrole Alkaloids Source classification Cynoglossumofficinale Linn. Plants Boraginaceae	mAChR
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) ^[1].

HY-121390

Lasiocarpine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields Boraginaceae Heliotropium europaeum L. Cancer	Endogenous Metabolite
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide ^[1].

HY-N16484

Trichodesmine N-oxide	Structural Classification Alkaloids Other Alkaloids Source classification Plants Trichodesma incanum (Bunge) A.DC. Boraginaceae	Others
Trichodesmine N-oxide is the oxidized form of a pyrrolizidine alkaloid (PA) that can be isolated from the sunn hemp (Crotalaria juncea) teas. PAs are secondary metabolites in plants, which may exhibit toxicity and carcinogenicity ^[1].

HY-N0830

Palmitic acid Maximum Cited Publications 76 Publications Verification	Cardiovascular Disease Natural Products Neurological Disease Classification of Application Fields Source classification Plants Endogenous metabolite Biological Pesticide Research Agricultural Research Human Gut Microbiota Metabolites Microorganisms other families Animals Disease Research Fields Cancer	HSP Endogenous Metabolite
Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model ^[1] .

HY-N0830A

Palmitic acid calcium	Human Gut Microbiota Metabolites Microorganisms Animals Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite	HSP Endogenous Metabolite
Palmitic acid calcium is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid calcium is used to establish a cell steatosis model ^[1] .

HY-N0830R

Palmitic acid (Standard) 70+ Cited Publications	Cardiovascular Disease Natural Products Neurological Disease Classification of Application Fields Source classification Plants Endogenous metabolite Biological Pesticide Research Agricultural Research Human Gut Microbiota Metabolites Microorganisms other families Animals Disease Research Fields Cancer	Reference Standards HSP Endogenous Metabolite
Palmitic acid (Standard) is the analytical standard of Palmitic acid. This product is intended for research and analytical applications. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0478

Neoline 1 Publications Verification Bullatine B	Alkaloids Piperidine Alkaloids other families Source classification Plants	Others
Neoline (Bullatine B) is the active ingredient of the active ingredient (PA), which can be used to cure the disease. Neoline Flow Suppression Nav1.7 Electrical Flow Control (VGSC), improve diabetes mechanical pain sensitivity. Neoline has a list of compounds that can be used, research on its use, and the quality of its processing during processing in pain ^[1] .

HY-W747907

4-Pyridoxolactone β-Pyracin	Structural Classification Natural Products Source classification Endogenous metabolite	Others
4-Pyridoxolactone (β-Pyracin) is a critical substrate in vitamin B6 degradation pathway I, primarily involved in the vitamin B6 metabolic process mediated by soil microorganisms. 4-Pyridoxolactone serves as the specific substrate for 4-pyridoxolactonase, undergoing a zinc-dependent lactone-ring hydrolysis reaction catalyzed by this enzyme to generate 4-pyridoxic acid (4PA) ^[1].

HY-N0801

Polygalacic acid	Triterpenes Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	MMP Cholinesterase (ChE)
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment ^[1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex .

HY-133541

Glucopiericidin A	Classification of Application Fields Disease Research Fields Cancer	GLUT ADC Payload Apoptosis
Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts ^[1] .

HY-N16465

Cinnamtannin D1	Source classification Phenols Polyphenols Plants Lauraceae Lindera glauca (Siebold & Zucc.) Blume	Apoptosis Reactive Oxygen Species (ROS) STAT
Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA) ^[1] .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Cardiovascular Disease Flavonols Flavonoids Typhaceae Classification of Application Fields Typha angustifolia L. Source classification Phenols Polyphenols Plants Disease Research Fields	Thrombin COX ERK JNK Factor Xa
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-146896S

16:0-18:1 PA-d31 sodium
16:0-18:1 PA-d₃₁ (sodium) is deuterium labeled 16:0-18:1 PA (sodium).

HY-10844S

Pretomanid-d4
Pretomanid-d₄ is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL ^[1] .

HY-N0830S18

Palmitic acid-d1
Palmitic acid-d is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-167600AS

18:0 PA-d70
18:0 PA-d₇₀ is deuterium labeled 18:0 PA0 ^[1].

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-128850S1

N-Acetyl-D-mannosamine-13C
N-Acetyl-D-mannosamine- ¹³C is the ¹³C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA) ^[1]

HY-128850S5

N-Acetyl-D-mannosamine-15N
N-Acetyl-D-mannosamine- ¹⁵N is the ¹⁵N labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA) ^[1]

HY-128850S2

N-Acetyl-D-mannosamine-13C-1
N-Acetyl-D-mannosamine- ¹³C-1 is the ¹³C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA) ^[1]

HY-15895S

Aprocitentan-d4
Aprocitentan-d₄ is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent ^[1].

HY-N0830S17

Palmitic acid-d2-4
Palmitic acid-d₂-4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0830S2

Palmitic acid-d31
Palmitic acid-d₃₁ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0830S15

Palmitic acid-d2-2
Palmitic acid-d₂-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0830S21

Palmitic acid-d5
Palmitic acid-d₅ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0830S6

Palmitic acid-13C16 3 Publications Verification
Palmitic acid- ¹³C₁₆ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0830S14

Palmitic acid-d17
Palmitic acid-d₁₇ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0830S13

Palmitic acid-d4-2
Palmitic acid-d₄-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0830S19

Palmitic acid-d2-5
Palmitic acid-d₂-5 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0830S16

Palmitic acid-d2-3
Palmitic acid-d₂-3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0830S20

Palmitic acid-d9
Palmitic acid-d₉ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-N0830S5

Palmitic acid-d3
Palmitic acid-d₃ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-Y0376S

Dimethylolpropionic acid-d7
Dimethylolpropionic acid-d₇ is the deuterium labeled Dimethylolpropionic acid ^[1].

HY-N0830S12

Palmitic acid-d4-1
Palmitic acid-d₄-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-109025AS

Baloxavir-d5
Baloxavir-d₅ is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity ^[1] .

HY-N0830S1

Palmitic acid-15,15,16,16,16-d5
Palmitic acid-15,15,16,16,16-d₅ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-146829S

1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate-d7 sodium
1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate-d₇ (sodium) is deuterium labeled 1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate (sodium).

HY-76569S1

(R)-Hydroxytolterodine-d14

(R)-Hydroxytolterodine-d₁₄ is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a K_B and a pA₂ of 0.84 nM and 9.14, respectively ^[1]. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .

HY-100634S

4-Hydroxypropranolol-d7 hydrochloride

4-Hydroxypropranolol-d₇ (hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties ^[1] .

HY-100634SA

4-Hydroxypropranolol-d7

4-Hydroxypropranolol-d₇ is the deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties ^[1] .

HY-B0281AS

Ranitidine-d6 hydrochloride

Ranitidine-d₆ hydrochloride is the deuterium labeled Ranitidine hydrochloride (HY-B0281A) ^[1]. Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine hydrochloride antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA₂ values of 7.2 and 6.95, respectively. Ranitidine hydrochloride inhibits breast tumor development and spread in mice .

HY-B0693S

Ranitidine-d6

Ranitidine-d₆ is the deuterium labeled Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine inhibits breast tumor development and spread in mice ^[1] .

HY-W751835

Baloxavir-d4

Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity ^[1] .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks