2. GPCR/G Protein
  3. Leukotriene Receptor
  4. MDL 43291

MDL 43291 is a competitive leukotriene (LT) receptor antagonist. MDL 43291 antagonize LTD4 and LTE4 with pA2 of 6.7. MDL 43291 does not antagonize histamine, carbachol or substance P. MDL 43291 can be used for the researches of inflammation and immunology, such as asthma.

For research use only. We do not sell to patients.

MDL 43291

MDL 43291 Chemical Structure

CAS No. : 129357-91-1

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MDL 43291 Related Antibodies

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

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Description

MDL 43291 is a competitive leukotriene (LT) receptor antagonist. MDL 43291 antagonize LTD4 and LTE4 with pA2 of 6.7. MDL 43291 does not antagonize histamine, carbachol or substance P. MDL 43291 can be used for the researches of inflammation and immunology, such as asthma[1].

IC50 & Target[1]

LTD4

6.7 (pA2)

LTE4

6.7 (pA2)

In Vivo

MDL 43291 (10-30 mg/kg, i.v.) effectively inhibits increases in insufflation pressure induced by LTD4 in guinea pig[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

438.66

Formula

C25H42O4S
CAS No.
SMILES

OC(CS[C@H]1[C@@](O2)([H])[C@](CCC2=O)([H])CC/C1=C/CCCCCCCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MDL 43291 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDL 43291129357-91-1MDL43291MDL-43291Leukotriene ReceptorLTD4LTE4leukotrieneinflammationimmunologyasthmaInhibitorinhibitorinhibit

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