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Results for "

inflammatory conditions

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA synthetase (1) Adenosine Receptor (1) Akt (9) AP-1 (2) Apoptosis (4) Autophagy (8) Bacterial (2) Bcl-2 Family (2) Biochemical Assay Reagents (1) Caspase (2) CCR (1) CD3 (1) CDK (2) Ceramidase (1) Collagen (1) Complement System (1) COX (13) Cyclic GMP-AMP Synthase (1) Drug Intermediate (2) Drug Metabolite (1) Endogenous Metabolite (30) Epigenetic Reader Domain (1) ERK (1) FABP (1) FGFR (1) Fungal (2) Galectin (1) Glucocorticoid Receptor (3) Glycosidase (1) HBV (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) HIV (6) HSP (1) IAP (1) IFNAR (2) iGluR (5) Integrin (2) Interleukin Related (14) IRAK (2) Isotope-Labeled Compounds (12) JAK (2) JNK (1) Lipoxygenase (1) MHC (1) MMP (5) mTOR (1) NADPH Oxidase (1) NF-κB (13) NO Synthase (7) NOD-like Receptor (NLR) (1) Notch (1) Opioid Receptor (9) p38 MAPK (2) Parasite (3) PARP (1) PD-1/PD-L1 (2) PDHK (2) Phosphatase (1) Phosphodiesterase (PDE) (5) PI3K (5) Potassium Channel (1) PPAR (1) PROTACs (1) RAD51 (2) Ras (2) Reactive Oxygen Species (ROS) (5) Reference Standards (13) RET (1) RIP kinase (1) ROR (1) SARS-CoV (1) STAT (5) Survivin (1) Syk (1) TGF-β Receptor (2) Tim3 (2) TNF Receptor (7) Transmembrane Glycoprotein (1) Tyrosinase (1) VEGFR (1) Wnt (3)
By Research Areas:	Cancer (39) Cardiovascular Disease (13) Infection (11) Inflammation/Immunology (86) Metabolic Disease (9) Neurological Disease (17)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Solubilizing Agents (1) Freeze-drying Protective Agents (1)

100

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124339

JNJ525	TNF Receptor	Inflammation/Immunology
JNJ525 (compound 1) is a TNFα inhibitor with the IC₅₀ values of 1.2 μM and 1.1 μM against of TNFR1 and TNFR2, respectively .

HY-B1087

Prednisolone hemisuccinate Prednisolone 21-hemisuccinate	Glucocorticoid Receptor	Inflammation/Immunology
Prednisolone hemisuccinate is a synthetic glucocorticoid, a derivative of cortisol, which is used to treat a variety of inflammatory and auto-immune conditions.

HY-116442

Azapropazone	Others	Inflammation/Immunology
Azapropazone is a nonsteroidal anti-inflammatory agent (NSAID). Azapropazone can be used for the research of rheumatoid arthritis and other rheumatoid conditions .

HY-N2154

Rhodojaponin V	Others	Inflammation/Immunology
Rhodojaponin V is a diterpenoid from the leaves of Rhododendron molle with anti-inflammatory activity. Rhodojaponin V is the C-14 acetylation product of Rhodojaponen III. L-Aspartic aicd sodium is commonly used in the study of inflammatory conditions .

HY-105656

Hydrocortisone phosphate sodium Hydrocortisone 21-phosphate sodium; Cortisol 21-phosphate sodium	Phosphatase	Infection
Hydrocortisone phosphate sodium is a soft steroid with low anti-inflammatory properties and a short duration of action. Hydrocortisone phosphate sodium can be used for the research for several ocular conditions and gastric ulcers .

HY-106583

Piroxicam cinnamate Cinnoxicam; SPA-S-510; Sinartol	COX	Inflammation/Immunology
Piroxicam cinnamate (Cinnoxicam) is a cyclooxygenase (COX) inhibitor, with anti-inflammatory activity. Piroxicam cinnamate is stable under gastric conditions, can be used for inflammatory-degenerative osteoarticular diseases, rheumatic disorders, and varicocele (VC) associated oligoasthenospermia research .

HY-132269

Isoflupredone	Glucocorticoid Receptor	Inflammation/Immunology
Isoflupredone belongs to the class of corticosteroids and exerts its effect by binding to glucocorticoid and mineralocorticoid receptors of animals, such as horses. Isoflupredone can be used in wide range of conditions, such as infection and inflammatory diseases .

HY-P991657

MEDI7814	Complement System	Cardiovascular Disease
MEDI7814 is a humanized monoclonal antibody inhibitor targeting C5a and C5adesArg. MEDI7814 binds to recombinant human C5a and serum purified human C5a with affinities of 14 pM and 8 pM, respectively. MEDI7814 is acute inflammatory diseases such as sepsis and renal ischemia-reperfusion injury .

HY-101945

A-69412	Lipoxygenase	Inflammation/Immunology
A-69412 is a reversible, specific inhibitor of the 5-lipoxygenase (5-LO). A-69412 has the potential to treat asthma and ulcerative colitis, and possibly other inflammatory and allergic conditions.

HY-116442R

Azapropazone (Standard)	Reference Standards Others	Inflammation/Immunology
Azapropazone (Standard) is the analytical standard of Azapropazone. This product is intended for research and analytical applications. Azapropazone is a nonsteroidal anti-inflammatory agent (NSAID). Azapropazone can be used for the research of rheumatoid arthritis and other rheumatoid conditions .

HY-132882

ARN19689	Ceramidase	Inflammation/Immunology
ARN19689 is a potent, selective, orally active and non-covalent inhibitor of N Acylethanolamine-Hydrolyzing Acid Amidase (NAAA), with an IC₅₀ of 42 nM. ARN19689 is a promising pharmacological tool to be further investigated in the field of inflammatory conditions .

HY-17609

Difelikefalin CR-845; FE-202845	Opioid Receptor	Neurological Disease Inflammation/Immunology
Difelikefalin (CR-845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-17474A

Parecoxib Sodium 5 Publications Verification SC 69124A	COX	Inflammation/Immunology Cancer
Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-17474

Parecoxib 5 Publications Verification SC 69124	COX	Inflammation/Immunology Cancer
Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-N0666A

L-Aspartic acid potassium 4 Publications Verification	Endogenous Metabolite	Inflammation/Immunology
Aspartic acid potassium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd potassium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd potassium commonly used in the study of inflammatory conditions .

HY-177318

αLβ2 integrin-IN-1	Integrin	Inflammation/Immunology
αLβ2 integrin-IN-1 (example 1) is an αLβ2 integrin mediated cell adhesion inhibitor that can be used for the study of αLβ2 integrin mediated inflammatory conditions .

HY-17609C

Difelikefalin acetate CR-845 acetate; FE-202845 acetate	Opioid Receptor	Neurological Disease
Difelikefalin (CR-845; FE-202845) acetate is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin acetate produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-N0666CR

L-Aspartic aicd sodium (Standard) Sodium L-aspartate (Standard)	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic aicd sodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd sodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd sodium commonly used in the study of inflammatory conditions .

HY-N0666DR

L-Aspartic aicd disodium (Standard) Disodium L-aspartate (Standard)	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid disodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic acid disodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic acid disodium commonly used in the study of inflammatory conditions .

HY-N0666C

L-Aspartic aicd sodium 4 Publications Verification Sodium L-aspartate	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic aicd sodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd sodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd sodium commonly used in the study of inflammatory conditions .

HY-N0666

L-Aspartic acid 4 Publications Verification	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-B0935S

Benzyl benzoate-d5	Parasite Endogenous Metabolite	Infection
Benzyl benzoate-d₅ is the deuterium labeled Benzyl benzoate . Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions .

HY-B0935S1

Benzyl benzoate-d12 1 Publications Verification Benzoic acid benzyl ester-d₁₂	Parasite Endogenous Metabolite	Infection
Benzyl benzoate-d₁₂ is the deuterium labeled Benzyl benzoate . Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions .

HY-N0666D

L-Aspartic aicd disodium 4 Publications Verification Disodium L-aspartate	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid disodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd disodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd disodium commonly used in the study of inflammatory conditions .

HY-132269R

Isoflupredone (Standard)	Glucocorticoid Receptor Reference Standards	Inflammation/Immunology
Isoflupredone (Standard) is the analytical standard of Isoflupredone. This product is intended for research and analytical applications. Isoflupredone belongs to the class of corticosteroids and exerts its effect by binding to glucocorticoid and mineralocorticoid receptors of animals, such as horses. Isoflupredone can be used in wide range of conditions, such as infection and inflammatory diseases .

HY-17474S

Parecoxib-d3 SC 69124-d₃	Isotope-Labeled Compounds COX	Inflammation/Immunology Cancer
Parecoxib-d3 is the deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-17474AR

Parecoxib Sodium (Standard) SC 69124A (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Parecoxib (Sodium) (Standard) is the analytical standard of Parecoxib (Sodium). This product is intended for research and analytical applications. Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-17474AS

Parecoxib-d5 sodium SC 69124A-d₅	Isotope-Labeled Compounds COX	Inflammation/Immunology Cancer
Parecoxib-d₅ sodium is the deuterium labeled Parecoxib sodium. Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo .

HY-17474R

Parecoxib (Standard) SC 69124 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Parecoxib (Standard) is the analytical standard of Parecoxib. This product is intended for research and analytical applications. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-N3239

Mulberrofuran G	Tyrosinase NADPH Oxidase HBV SARS-CoV Reactive Oxygen Species (ROS) JAK STAT Apoptosis Caspase PARP	Infection Neurological Disease Inflammation/Immunology Cancer
Mulberrofuran G is a NOX inhibitor (IC₅₀: 6.9 μM) and tyrosinase inhibitor. Mulberrofuran G exhibits anti-inflammatory, antioxidant, antiviral, antitumor, and neuroprotective effects. Mulberrofuran G can be used in the research of tumors, nervous system diseases, and other conditions .

HY-17474S1

Parecoxib-d5 SC 69124-d₅	Isotope-Labeled Compounds COX	Inflammation/Immunology Cancer
Parecoxib-d₅ (SC 69124-d₅) is deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-W007539

2,4-Dihydroxybenzaldehyde	Endogenous Metabolite Drug Intermediate NO Synthase Reactive Oxygen Species (ROS) COX	Metabolic Disease Inflammation/Immunology
2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions .

HY-139780

JNJ-61803534	ROR	Inflammation/Immunology
JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC₅₀ of 9.6 nM. JNJ-61803534 has anti-inflammatory activity. JNJ-61803534 inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions .

HY-N0666S

L-Aspartic acid-13C	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid- ¹³C is a ¹³C labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S3

L-Aspartic acid-15N	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid- ¹⁵N is the ¹⁵N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S2

DL-Aspartic acid-d3	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
DL-Aspartic acid-d₃ is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S8

L-Aspartic acid-d3	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid-d₃ is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-B0715

Pentoxifylline Maximum Cited Publications 9 Publications Verification BL-191; PTX; Oxpentifylline	Phosphodiesterase (PDE) Autophagy HIV	Cardiovascular Disease Cancer
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-N0666S4

L-Aspartic acid-13C4	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid- ¹³C₄ is the ¹³C-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666AR

L-Aspartic acid potassium (Standard)	Reference Standards Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid (potassium) (Standard) is the analytical standard of L-Aspartic acid (potassium). This product is intended for research and analytical applications. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S10

L-Aspartic acid-C13-1 [3-¹³C]Aspartic acid	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid- ¹³C-1 is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666R

L-Aspartic acid (Standard) 1 Publications Verification	Reference Standards Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid (Standard) is the analytical standard of L-Aspartic acid. This product is intended for research and analytical applications. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-W011340

5-Hydroxy flunixin	Drug Metabolite Endogenous Metabolite	Inflammation/Immunology
5-Hydroxy flunixin, the principal metabolite of Flunixin (HY-121046), retains the Flunixin's anti-inflammatory properties and plays a significant role in mitigating pain and inflammation in various veterinary applications. It assists in alleviating conditions such as colic in horses, musculoskeletal disorders, and infectious diseases in cattle, while also supporting the management of mastitis-metritis-agalactia syndrome in sows.

HY-N2907

Atranorin	Wnt Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT	Infection Neurological Disease Inflammation/Immunology Cancer
Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-174455

APH02174	PROTACs IRAK Interleukin Related	Inflammation/Immunology
APH02174 is a highly selective and orally active IRAK4 PROTAC degrader with the DC₅₀ of 4.01 nM in THP-1 cells. APH02174 blocks inflammatory signals by inhibiting IL-6 release. APH02174 can be used for research on inflammatory conditions such as psoriasis vulgaris and rheumatoid arthritis. (Pink: IRAK4 Ligand (HY-174470); Blue: CRBN Ligand (HY-45512); Black: Linker; CRBN Ligand+Linker (HY-174796))

HY-17609S

Difelikefalin-d5 CR-845-d₅; FE-202845-d₅	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease
Difelikefalin-d₅ (CR-845-d₅) is deuterium labeled Difelikefalin. Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-174801

XL-3156	Cyclic GMP-AMP Synthase	Inflammation/Immunology
XL-3156 is a potent, selective, and cross-species cGAS inhibitor. XL-3156 can simultaneously occupy both allosteric and orthosteric sites, and inhibit the interaction and phase separation between cGAS and DNA by stabilizing the closed conformation of the activation loop. XL-3156 can be used in the research of autoimmune diseases, inflammatory conditions and other diseases .

HY-77048

IRAK-4 protein kinase inhibitor 2	IRAK	Inflammation/Immunology
IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC₅₀ of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders .

HY-N0666E

L-Aspartic acid (monocesium)	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid monocesium is the monocesium salt form of L-Aspartic acid (HY-N0666). L-Aspartic aicd monocesium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd monocesium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd monocesium commonly used in the study of inflammatory conditions .

HY-17609S1

Difelikefalin-d5 hydrochloride CR-845-d₅ hydrochloride; FE-202845-d₅ hydrochloride	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease Inflammation/Immunology
Difelikefalin-d₅ (CR-845-d₅) hydrochloride is the deuterium labeled Difelikefalin (HY-17609). Difelikefalin (CR-845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

Cat. No.	Product Name

HY-L230

FDA Kinase Inhibitor Library

323 compounds

Kinases are enzymes that catalyze the addition of phosphate groups to substrate molecules, a process known as phosphorylation. Protein phosphorylation serves as a critical regulatory mechanism for numerous cellular processes, including cell division, metabolism, and signal transduction. The human genome encodes over 500 kinases, which collectively regulate approximately 50% of cellular functions. Due to their pivotal roles, kinases represent one of the most important target classes in drug development.

Kinase inhibitors can selectively block the activity of disease-associated kinases, making them valuable therapeutics for conditions such as cancer and inflammatory diseases. FDA-approved kinase inhibitors have undergone extensive preclinical and clinical studies, demonstrating high bioactivity, favorable safety profiles, and good bioavailability, rendering them suitable for investigating new therapeutic indications.

HY-L022M

FDA-Approved Drug Library Mini

3,163 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.

MCE owns a unique collection of 3,163 approved compounds which have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. The package of this library is 96-well microplate with peelable foil seal, which makes the screening process easier and faster.

Cat. No.	Product Name	Target	Research Area

HY-17609

Difelikefalin CR-845; FE-202845	Opioid Receptor	Neurological Disease Inflammation/Immunology
Difelikefalin (CR-845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

Cat. No.	Product Name	Target	Research Area

HY-P990122

Anti-Rat IL-4 Antibody (OX-81)	Interleukin Related	Inflammation/Immunology
Anti-Rat IL-4 Antibody (OX-81) is an antibody inhibitor against rat IL-4. Anti-Rat IL-4 Antibody (OX-81) can specifically block the anti-inflammatory effect of IL-4. Anti-Rat IL-4 Antibody (OX-81) can be used for research on inflammation conditions such as experimental allergic encephalomyelitis (EAE) .

HY-P99121

Anti-Mouse/Human CD11b Antibody (M1/70)	Integrin	Inflammation/Immunology Cancer
Anti-Mouse/Human CD11b Antibody (M1/70) is an anti-mouse CD11b IgG2b monoclonal antibody. Anti-Mouse/Human CD11b Antibody (M1/70) can significantly inhibit the adhesion between dendritic cells (DCs) and platelets. Anti-Mouse/Human CD11b Antibody (M1/70) can kill ovarian cancer cells and inhibit their migration. Anti-Mouse/Human CD11b Antibody (M1/70) can alleviate renal fibrosis and inflammation. Anti-Mouse/Human CD11b Antibody (M1/70) can be used for researches on inflammation conditions and cancer such as ischemia-reperfusion injury (IRI), thrombotic inflammatory conditions and ovarian cancer .

HY-P99149

Anti-Mouse TNFR2 Antibody (TR75-54.7)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse TNFR2 IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer .

HY-P990802

Anti-Mouse CD3ε Antibody (145-2C11)	CD3	Metabolic Disease Inflammation/Immunology
Anti-Mouse CD3ε Antibody (145-2C11) is an orally active anti-mouse CD3ε IgG1 monoclonal antibody. Anti-Mouse CD3ε Antibody (145-2C11) can inhibit the proliferation of effector T cells and improve the function of regulatory T cells (Tregs). Anti-Mouse CD3ε Antibody (145-2C11) relieves inflammatory response by inhibiting the production of pro-inflammatory cytokines and increasing the secretion of anti-inflammatory factors. Anti-Mouse CD3ε Antibody (145-2C11) can be used for researches on metabolic and immune system conditions such as diabetes and lupus. The recommend isotype control of Anti-Mouse CD3ε Antibody (145-2C11): Armenian hamster IgG, Isotype Control (HY-P990305) .

HY-P990208

Anti-Mouse IL-9 Antibody (9C1)	Interleukin Related NF-κB Parasite	Infection Inflammation/Immunology Cancer
Anti-Mouse IL-9 Antibody (9C1) is an anti-mouse IL-9 IgG2a monoclonal antibody. Anti-Mouse IL-9 Antibody (9C1) can reduce the activation of NF-κB signaling pathway and decrease the infiltration of inflammatory cells. Anti-Mouse IL-9 Antibody (9C1) effectively reduces Th9 cell-mediated allergic reactions and anti-tumor effects. Anti-Mouse IL-9 Antibody (9C1) can be used for researches on inflammation, infection conditions and cancer such as parasitic infections, allergic reactions, breast cancer and osteosarcoma .

HY-P990242

Anti-Mouse Galectin-9 Antibody (RG9-1)	Galectin TNF Receptor IFNAR Interleukin Related	Inflammation/Immunology Cancer
Anti-Mouse Galectin-9 Antibody (RG9-1) is an anti-mouse Galectin-9 IgG2b monoclonal antibody. Anti-Mouse Galectin-9 Antibody (RG9-1) promotes inflammatory response by enhancing the secretion of IFN-γ, TNF-α, and IL-6. Anti-Mouse Galectin-9 Antibody (RG9-1) can increase CD8 T cell and Treg frequency. Anti-Mouse Galectin-9 Antibody (RG9-1) reduces graft survival time by increasing CD4 ⁺ and CD8 ⁺ T cell infiltration. Anti-Mouse Galectin-9 Antibody (RG9-1) can be used for researches on inflammation conditions, cancer and xenotransplantation such as ischemia-reperfusion, colon cancer, breast cancer and leukemia .

HY-P990294

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)	Transmembrane Glycoprotein STAT Collagen Reactive Oxygen Species (ROS) Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an anti-mouse CD106/VCAM-1 IgG1 monoclonal antibody. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) reduces inflammatory response and oxidative stress by lowering p-STAT3 and reactive oxygen species (ROS) levels. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can alleviate cardiac inflammation and fibrosis by reducing the expression of collagen I and collagen III. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can be used for research on cardiovascular conditions such as hypertensive heart condition and subretinal fibrosis .

HY-P991657

MEDI7814	Complement System	Cardiovascular Disease
MEDI7814 is a humanized monoclonal antibody inhibitor targeting C5a and C5adesArg. MEDI7814 binds to recombinant human C5a and serum purified human C5a with affinities of 14 pM and 8 pM, respectively. MEDI7814 is acute inflammatory diseases such as sepsis and renal ischemia-reperfusion injury .

HY-P990160

Anti-Rat TCR alpha/beta Antibody (R73)	MHC	Neurological Disease Metabolic Disease Inflammation/Immunology
Anti-Rat TCR alpha/beta Antibody (R73) is an anti-mouse TCR alpha/beta IgG1 monoclonal antibody. Anti-Rat TCR alpha/beta Antibody (R73) suppresses immune response by depleting α/β ⁺ T cells. Anti-Rat TCR alpha/beta Antibody (R73) can inhibit the expression of pro-inflammatory cytokines. Anti-Rat TCR alpha/beta Antibody (R73) can extend graft survival time by reducing infiltration of T cells and neutrophils. Anti-Rat TCR alpha/beta Antibody (R73) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as arthritis, acute inflammatory peripheral neuropathy and diabetes .

HY-P990239

Anti-Human/Mouse GRP78 Antibody (N88)	HSP Akt Interleukin Related	Inflammation/Immunology Cancer
Anti-Human/Mouse GRP78 Antibody (N88) is an anti-human/mouse GRP78 IgG1 monoclonal antibody. Anti-Human/Mouse GRP78 Antibody (N88) can activate the Akt signaling pathway. Anti-Human/Mouse GRP78 Antibody (N88) can inhibit the expression of inflammatory factors and plasminogen activator inhibitors induced by TLR agonists. Anti-Human/Mouse GRP78 Antibody (N88) can be used for research on inflammation conditions. Anti-Human/Mouse GRP78 Antibody (N88) can be used for immunoprecipitation .

HY-P990252

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)	Notch Interleukin Related NF-κB VEGFR FGFR NO Synthase	Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the DLL4-Notch signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors (IL-1β, iNOS, IL-6) levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and IL-17A production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma .

HY-P990297

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human CCL2/MCP-1 IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2154

Rhodojaponin V	other families Classification of Application Fields Terpenoids Rhododendron molle G. Don Source classification Diterpenoids Ericaceae Plants Inflammation/Immunology Disease Research Fields	Others
Rhodojaponin V is a diterpenoid from the leaves of Rhododendron molle with anti-inflammatory activity. Rhodojaponin V is the C-14 acetylation product of Rhodojaponen III. L-Aspartic aicd sodium is commonly used in the study of inflammatory conditions .

HY-N0666A

L-Aspartic acid potassium 4 Publications Verification	Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
Aspartic acid potassium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd potassium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd potassium commonly used in the study of inflammatory conditions .

HY-N0666C

L-Aspartic aicd sodium 4 Publications Verification Sodium L-aspartate	Microorganisms other families Animals Classification of Application Fields Source classification Other Diseases Amino acids Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Aspartic aicd sodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd sodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd sodium commonly used in the study of inflammatory conditions .

HY-N0666

L-Aspartic acid 4 Publications Verification	Cardiovascular Disease Classification of Application Fields Source classification Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666D

L-Aspartic aicd disodium 4 Publications Verification Disodium L-aspartate	Cardiovascular Disease Classification of Application Fields Source classification Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Aspartic acid disodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd disodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd disodium commonly used in the study of inflammatory conditions .

HY-N3239

Mulberrofuran G	Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	Tyrosinase NADPH Oxidase HBV SARS-CoV Reactive Oxygen Species (ROS) JAK STAT Apoptosis Caspase PARP
Mulberrofuran G is a NOX inhibitor (IC₅₀: 6.9 μM) and tyrosinase inhibitor. Mulberrofuran G exhibits anti-inflammatory, antioxidant, antiviral, antitumor, and neuroprotective effects. Mulberrofuran G can be used in the research of tumors, nervous system diseases, and other conditions .

HY-W007539

2,4-Dihydroxybenzaldehyde	Monophenols Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Drug Intermediate NO Synthase Reactive Oxygen Species (ROS) COX
2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions .

HY-B0715

Pentoxifylline Maximum Cited Publications 9 Publications Verification BL-191; PTX; Oxpentifylline	Classification of Application Fields Disease Research Fields Cancer	Phosphodiesterase (PDE) Autophagy HIV
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-N0666CR

L-Aspartic aicd sodium (Standard) Sodium L-aspartate (Standard)	Microorganisms other families Animals Source classification Amino acids Plants Endogenous metabolite	Endogenous Metabolite
L-Aspartic aicd sodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd sodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd sodium commonly used in the study of inflammatory conditions .

HY-N0666DR

L-Aspartic aicd disodium (Standard) Disodium L-aspartate (Standard)	Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
L-Aspartic acid disodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic acid disodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic acid disodium commonly used in the study of inflammatory conditions .

HY-N0666AR

L-Aspartic acid potassium (Standard)	Source classification Amino acids Endogenous metabolite	Reference Standards Endogenous Metabolite
L-Aspartic acid (potassium) (Standard) is the analytical standard of L-Aspartic acid (potassium). This product is intended for research and analytical applications. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666R

L-Aspartic acid (Standard) 1 Publications Verification	Immune System Disorder Microorganisms Source classification Disease markers Endocrine diseases Amino acids Endogenous metabolite	Reference Standards Endogenous Metabolite
L-Aspartic acid (Standard) is the analytical standard of L-Aspartic acid. This product is intended for research and analytical applications. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N2907

Atranorin	other families Classification of Application Fields Source classification Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Cancer	Wnt Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT
Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-N2303

Eriocalyxin B 3 Publications Verification	Natural Products Classification of Application Fields Labiatae Senna sophera (L.) Roxb. Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis NF-κB Autophagy Reactive Oxygen Species (ROS) CDK PPAR FABP Akt mTOR
Eriocalyxin B is a diterpenoid compound that can be isolated from Chinese herb Isodon eriocalyx. Eriocalyxin B exhibits multiple activities, such as anti-cancer, anti-inflammatory, and inhibition of adipogenesis. Eriocalyxin B is capable of inducing apoptosis and autophagy in tumor cells. Eriocalyxin B can be used in the research of cancers, autoimmune diseases, and other conditions .

HY-125740

Malvidin-3-glucoside chloride Malvidin-3-O-glucoside chloride; Oenin chloride	Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Anthocyans Flavonoids Sunscreen Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields	NF-κB TNF Receptor NO Synthase Interleukin Related
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health .

HY-N0666B

Aspartic acid calcium 4 Publications Verification Calcium L-aspartate	Cardiovascular Disease Microorganisms other families Animals Classification of Application Fields Source classification Amino acids Plants Disease Research Fields	Endogenous Metabolite
Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic aicd calcium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd calcium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd calcium commonly used in the study of inflammatory conditions .

HY-W007539R

2,4-Dihydroxybenzaldehyde (Standard)	Monophenols Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Endogenous metabolite	Reference Standards Endogenous Metabolite Drug Intermediate NO Synthase Reactive Oxygen Species (ROS) COX
2,4-Dihydroxybenzaldehyde (Standard) is the analytical standard of 2,4-Dihydroxybenzaldehyde. This product is intended for research and analytical applications. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions .

HY-N2907R

Atranorin (Standard)	other families Source classification Phenols Polyphenols Plants Endogenous metabolite	Wnt Reference Standards Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT
Atranorin (Standard) is the analytical standard of Atranorin (HY-N2907). This product is intended for research and analytical applications. Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-N0976

1,11b-Dihydro-11b-hydroxymedicarpin 11b-Hydroxy-11b,1-dihydromedicarpin	Natural Products Classification of Application Fields Leguminosae Derris robusta Source classification Plants Inflammation/Immunology Disease Research Fields	Interleukin Related Wnt
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative . Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways . Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice .

HY-125740R

Malvidin-3-glucoside chloride (Standard) Malvidin-3-O-glucoside chloride (Standard); Oenin chloride (Standard)	Anthocyans Flavonoids Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	Reference Standards Interleukin Related NO Synthase NF-κB TNF Receptor
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride (Standard) is the analytical standard of Malvidin-3-glucoside chloride (HY-125740). This product is intended for research and analytical applications. Malvidin-3-glucoside chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health .

HY-N3980

Guaiol Champacol; Guaiac alcohol	Infection Natural Products Classification of Application Fields Source classification Distemonanthus benthamianus Baill. Plants Compositae Disease Research Fields	Autophagy RAD51
Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC₅₀ of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions ^[4]

HY-N3980R

Guaiol (Standard) Champacol (Standard); Guaiac alcohol (Standard)	Natural Products Source classification Distemonanthus benthamianus Baill. Plants Compositae	Reference Standards Autophagy RAD51
Guaiol (Standard) is the analytical standard of Guaiol. This product is intended for research and analytical applications. Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions [4]

HY-N16450

Cnidilide	Natural Products Source classification Plants	NO Synthase COX Interleukin Related TNF Receptor p38 MAPK JNK NF-κB
Cnidilide is a natural product of alkylphthalein. Cnidilide can be isolated from the rhizomes of Cnidium officinale. Cnidilide reduces the production of NO and PGE2 by inhibiting the expression of iNOS and COX-2 induced by LPS (HY-D1056). Cnidilide can inhibit pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Cnidilide can specifically inhibit the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Cnidilide blocks the signaling pathway by inhibiting the transcriptional activity of AP-1 and NF-κB. can be used for research on inflammation conditions .

HY-N15378

β-Carotene-15,15'-epoxide	Natural Products Source classification Spondias mombin L. Plants Anacardiaceae	IAP Bcl-2 Family COX TNF Receptor Caspase Apoptosis
β-carotene-15,15ʹ-epoxide is a XIAP antagonist with apoptosis-inducing and antitumor activity, found in the leaves of Spondias mombin. In a DMBA (HY-W011845)-induced rat model of breast cancer, β-carotene-15,15ʹ-epoxide binds to the BIR3 domain of the anti-apoptotic protein XIAP, blocking its interaction with caspase-9 and thereby promoting tumor cell apoptosis. In addition, β-carotene-15,15ʹ-epoxide significantly downregulates the expression of BCL-2, COX-2, and TNF-α in tumor tissues, reduces MDA levels, increases catalase activity, and modulates serum levels of LDH, ALP, and ALT, demonstrating strong antioxidant, anti-inflammatory, and metabolic protective effects. β-carotene-15,15ʹ-epoxide may be used in research on inflammation-related conditions and cancers such as breast cancer .

Cat. No.	Product Name	Chemical Structure

HY-B0935S

Benzyl benzoate-d5
Benzyl benzoate-d₅ is the deuterium labeled Benzyl benzoate . Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions .

HY-B0935S1

Benzyl benzoate-d12 1 Publications Verification
Benzyl benzoate-d₁₂ is the deuterium labeled Benzyl benzoate . Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions .

HY-N0666S

L-Aspartic acid-13C
L-Aspartic acid- ¹³C is a ¹³C labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S3

L-Aspartic acid-15N
L-Aspartic acid- ¹⁵N is the ¹⁵N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S2

DL-Aspartic acid-d3
DL-Aspartic acid-d₃ is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S8

L-Aspartic acid-d3
L-Aspartic acid-d₃ is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S4

L-Aspartic acid-13C4
L-Aspartic acid- ¹³C₄ is the ¹³C-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-17474S

Parecoxib-d3

Parecoxib-d3 is the deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-17474AS

Parecoxib-d5 sodium

Parecoxib-d₅ sodium is the deuterium labeled Parecoxib sodium. Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo .

HY-17474S1

Parecoxib-d5

Parecoxib-d₅ (SC 69124-d₅) is deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-N0666S10

L-Aspartic acid-C13-1
L-Aspartic acid- ¹³C-1 is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-17609S

Difelikefalin-d5
Difelikefalin-d₅ (CR-845-d₅) is deuterium labeled Difelikefalin. Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-17609S1

Difelikefalin-d5 hydrochloride
Difelikefalin-d₅ (CR-845-d₅) hydrochloride is the deuterium labeled Difelikefalin (HY-17609). Difelikefalin (CR-845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-N0666S9

L-Aspartic acid-15N,d3
L-Aspartic acid- ¹⁵N,d₃ is the deuterium and ¹⁵N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S6

L-Aspartic acid-1,4-13C2
L-Aspartic acid-1,4- ¹³C₂ is the ¹³C-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-B0715S

Pentoxifylline-d6

Pentoxifylline-d₆ is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-B0715S2

Pentoxifylline-d5

Pentoxifylline-d₅ is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-N0666S1

L-Aspartic acid-13C4,15N
L-Aspartic acid- ¹³C₄, ¹⁵N is the ¹³C-labeled and ¹⁵N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S7

L-Aspartic acid-1,4-13C2,15N
L-Aspartic acid-1,4- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-N0666S5

L-Aspartic acid-13C4,15N,d3
L-Aspartic acid- ¹³C₄, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-B0715S3

Pentoxifylline-d3

Pentoxifylline-d₃ (BL-191-d₃) is deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-126242S

Tyk2-IN-7

Tyk2-IN-7 is an orally active TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC₅₀ and K_i.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 can inhibit the IL-23 and IFN-α signaling pathways. Tyk2-IN-7 is commonly used in the study of inflammatory conditions such as colitis .

HY-144224S

Tianeptine-d6 hydrochloride

Tianeptine-d₆ hydrochloride is the deuterium labeled Tianeptine hydrochloride. Tianeptine hydrochloride is an atypical antidepressant. Tianeptine hydrochloride is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine hydrochloride is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine hydrochloride increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine hydrochloride exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine hydrochloride inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine hydrochloride can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.

HY-90003S

Tianeptine-d12

Tianeptine-d₁₂ is a deuterated analog of Tianeptine (HY-90003).Tianeptine is an atypical antidepressant. Tianeptine is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.

Cat. No.	Product Name		Classification

HY-W748514

(4-(Bromomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone		Alkynes
(4-(Bromomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is a compound with anticancer activity that can effectively inhibit the growth of tumor cells and shows potential application value in compound development. The compound has also been studied for the improvement of certain neuropathological conditions and as a candidate compound for anti-inflammatory inhibition.

Cat. No.	Product Name		Classification

HY-N0666

L-Aspartic acid 4 Publications Verification		Freeze-drying Protective Agents Solubilizing Agents
L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

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