2. Immunology/Inflammation
  3. Cyclic GMP-AMP Synthase
  4. XL-3156

XL-3156 is a potent, selective, and cross-species cGAS inhibitor. XL-3156 can simultaneously occupy both allosteric and orthosteric sites, and inhibit the interaction and phase separation between cGAS and DNA by stabilizing the closed conformation of the activation loop. XL-3156 can be used in the research of autoimmune diseases, inflammatory conditions and other diseases.

For research use only. We do not sell to patients.

XL-3156 Chemical Structure

XL-3156 Chemical Structure

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XL-3156 Related Antibodies

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Description

XL-3156 is a potent, selective, and cross-species cGAS inhibitor. XL-3156 can simultaneously occupy both allosteric and orthosteric sites, and inhibit the interaction and phase separation between cGAS and DNA by stabilizing the closed conformation of the activation loop. XL-3156 can be used in the research of autoimmune diseases, inflammatory conditions and other diseases[1].

Molecular Weight

517.54

Formula

C28H23N9O2
SMILES

CC1=NN(C(O)=C1C(C2=C(N(N=C2C)C3=NC4=CC=CC=C4N3)O)C5=NC=CC=C5)C6=NC7=CC=CC=C7N6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XL-3156 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XL-3156XL3156XL 3156Cyclic GMP-AMP SynthasecGASHEK-293RAW-ISGL929THP-1 DualTHP1-Lucia ISGmiceInhibitorinhibitorinhibit

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XL-3156
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HY-174801
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