2. Immunology/Inflammation Apoptosis MAPK/ERK Pathway NF-κB
  3. NO Synthase COX Interleukin Related TNF Receptor p38 MAPK JNK NF-κB
  4. Cnidilide

Cnidilide is a natural product of alkylphthalein. Cnidilide can be isolated from the rhizomes of Cnidium officinale. Cnidilide reduces the production of NO and PGE2 by inhibiting the expression of iNOS and COX-2 induced by LPS (HY-D1056). Cnidilide can inhibit pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Cnidilide can specifically inhibit the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Cnidilide blocks the signaling pathway by inhibiting the transcriptional activity of AP-1 and NF-κB. can be used for research on inflammation conditions.

For research use only. We do not sell to patients.

Cnidilide

Cnidilide Chemical Structure

CAS No. : 3674-03-1

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Cnidilide Related Antibodies

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nNOS iNOS eNOS

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COX COX-1 COX-2 COX-3

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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JNK1 JNK2 JNK3 JNK

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

Cnidilide is a natural product of alkylphthalein. Cnidilide can be isolated from the rhizomes of Cnidium officinale. Cnidilide reduces the production of NO and PGE2 by inhibiting the expression of iNOS and COX-2 induced by LPS (HY-D1056). Cnidilide can inhibit pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Cnidilide can specifically inhibit the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Cnidilide blocks the signaling pathway by inhibiting the transcriptional activity of AP-1 and NF-κB. can be used for research on inflammation conditions[1].

IC50 & Target[1]

IL-1β

 

IL-6

 

COX-2

 

Molecular Weight

194.27

Formula

C12H18O2
CAS No.
SMILES

CCCC[C@H]1[C@]2([H])[C@](C=CCC2)([H])C(O1)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cnidilide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cnidilide3674-03-1NO SynthaseCOXInterleukin RelatedTNF Receptorp38 MAPKJNKNF-κBNitric oxide synthasesNOSCyclooxygenaseILTumor Necrosis Factor ReceptorTNFRc-Jun N-terminal kinaseNuclear factor-κBNuclear factor-kappaBiNOSCOX-2NOIL-1βIL-6TNFαp38MAPKInhibitorinhibitorinhibit

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