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Results for "

hepatitis B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HBV (131) HCV (50) 17β-HSD (3) Acetyl-CoA Carboxylase (2) Acyltransferase (3) Aminotransferases (Transaminases) (3) AMPK (2) Amyloid-β (1) Antibiotic (4) Apoptosis (7) Atg8/LC3 (1) Autophagy (3) Bacterial (3) Bcl-2 Family (2) BCRP (3) Biochemical Assay Reagents (1) Carbonic Anhydrase (2) Caspase (2) Claudin (1) Cytochrome P450 (1) Dengue Virus (3) DGK (1) DNA/RNA Synthesis (10) Drug Derivative (1) Drug Metabolite (1) Endogenous Metabolite (8) Estrogen Receptor/ERR (2) Ferroptosis (2) Flavivirus (3) Fungal (2) GABA Receptor (1) Glycosidase (2) HCV Protease (11) HIF/HIF Prolyl-Hydroxylase (2) HIV (27) HPV (1) HSV (3) IFNAR (1) Influenza Virus (4) Interleukin Related (6) Isotope-Labeled Compounds (8) Liposome (1) MMP (2) Myosin (2) Nucleoside Antimetabolite/Analog (3) OAT (3) Orthopoxvirus (1) P-glycoprotein (1) p62 (1) Phosphodiesterase (PDE) (1) Potassium Channel (1) PPAR (2) PROTACs (2) Pyroptosis (2) Reference Standards (19) Reverse Transcriptase (19) RSV (1) SARS-CoV (12) Sirtuin (1) Small Interfering RNA (siRNA) (2) Toll-like Receptor (TLR) (2) Transthyretin (TTR) (2) Virus Protease (2)
By Research Areas:	Cancer (27) Cardiovascular Disease (5) Endocrinology (1) Infection (202) Inflammation/Immunology (25) Metabolic Disease (11) Neurological Disease (5)
Oligonucleotides:	A (2) Nucleosides and their Analogs (5) C (3) siRNA drugs (3) Antisense Oligonucleotides (2) Cholesterol (1) siRNAs (3)

219

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Hepatitis E Virus (HEV) HCV HBV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1774

Hepatitis B Virus Core (128-140)	HBV	Infection
Hepatitis B Virus Core (128-140) is a peptide of hepatitis B virus core protein.

HY-109168

Bersacapavir 2 Publications Verification JNJ-6379; JNJ-56136379	HBV	Infection
Bersacapavir (JNJ-6379) is a novel Hepatitis B Virus capsid assembly modulator. Bersacapavir interferes with the assembly process of the hepatitis B virus nucleocapsid by binding to the hydrophobic pocket at the dimer-dimer interface of hepatitis B core protein (HBc) subunits. Bersacapavir inhibits the replication of HBV. Bersacapavir is mainly used in the research of chronic hepatitis B .

HY-P99693

Lenvervimab GC1102	HBV	Infection
Lenvervimab (GC1102) is a IgG1-type recombinant human hepatitis B Immunoglobulin. Lenvervimab can be used for research of hepatitis B virus infection .

HY-114314

BA-53038B	HBV	Infection
BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC₅₀ value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B .

HY-P4042

Hepatitis B Virus Receptor Binding Fragment hepatitis B peptide 4980	HBV	Infection Inflammation/Immunology
Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization .

HY-P4043

Hepatitis b virus pre-s region (120-145)	HBV	Infection Inflammation/Immunology
Hepatitis b virus pre-s region (120-145) is a preS2 peptide that inhibits the binding of single-chain Fv fragment (scFv) or IgG to r-HBsAg .

HY-P99541

Tuvirumab anti-hepatitis B; OST 577; SDZ-OST 577	HBV	Infection
Tuvirumab (OST 577; SDZ-OST 577) is a human IgG1 subclass monoclonal antibody directed against HBV surface antigen (HBsAg). Tuvirumab binds specifically and with high affinity (K=3.6 nM) to HBsAg. Tuvirumab has the potential for chronic hepatitis B research .

HY-P4038

Hepatitis C Virus S5A/5B	HCV Protease	Infection
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .

HY-171181

ZINC20451377	HBV	Infection
ZINC20451377 is a small molecule targeting hepatitis B (HBV) surface antigen (HBsAg) and can effectively inhibit wild-type hepatitis B and tenofovir (HY-13910)-resistant hepatitis B .

HY-115430

Tenofovir disoproxil aspartate	HIV Reverse Transcriptase HBV	Infection
Tenofovir disoproxil aspartate is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic Hepatitis B .

HY-121513

Torcitabine 2'-Deoxy-L-cytidine; L-dC	HBV	Infection
Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection treatment .

HY-173278

AIC263282	HBV Potassium Channel	Infection
AIC263282 is a potent Hepatitis B Virus (HBV) capsid assembly modulator with an EC₅₀ of 3.8 nM. AIC263282 shows an IC₅₀ of 61 nM for hERG. AIC263282 exhibits activity against viral replication and hepatitis B surface antigen (HBsAG) on primary human hepatocytes .

HY-149158

CCC-0975	HBV	Inflammation/Immunology
CCC-0975 is a hepatitis B virus (HBV) inhibitor (EC₅₀=10 μM). CCC-0975 interferes with the conversion of relaxed circular DNA (rcDNA) to cccDNA, synchronously reducing cccDNA and its precursor deproteinized rcDNA (DP-rcDNA) without promoting their intracellular degradation. CCC-0975 is promising for research of chronic hepatitis B .

HY-P4051

HBV Seq1 aa:141-151	HBV	Infection Inflammation/Immunology
HBV Seq1 aa:141-151 is a peptide. HBV Seq1 aa:141-151 can be used for the research of chronic hepatitis B virus (HBV) .

HY-147255

Canocapavir ZM-H1505R	HBV	Infection
Canocapavir (ZM-H1505R) has orally antiviral activity. Canocapavir is a HBV capsid inhibitor that can be used in the research of Chronic hepatitis B. .

HY-P4045

HBV Seq2 aa:208-216	HBV	Infection
HBV Seq2 aa:208-216, a HBsAg derived CD8 epitope peptide, is studied as part of Large envelope protein from Hepatitis B virus .

HY-147255A

(S)-Canocapavir (S)-ZM-H1505R	HBV	Infection
(S)-Canocapavir is the isomer of Canocapavir (HY-147255A). Canocapavir (ZM-H1505R) has orally antiviral activity. Canocapavir is a HBV capsid inhibitor that can be used in the research of Chronic hepatitis B .

HY-125719

Clevudine triphosphate L-FMAU-TP	HBV	Infection Cancer
Clevudine triphosphate is a thymidine analog. Clevudine triphosphate has anti-human hepatitis B virus (HBV) activity .

HY-148201

Oleana-2,12-dien-28-oic acid	HBV	Infection
Oleana-2,12-dien-28-oic acid is an HBV-DNA inhibitor, HBsAg and HBeAg inhibitor. Oleana-2,12-dien-28-oic acid can be used in hepatitis B virus infection disease research .

HY-W352344

2'-Deoxy-L-adenosine	HBV	Infection
2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV) .

HY-133721

Chamaechromone	HBV	Infection Inflammation/Immunology
Chamaechromone is a biflavonoid ingredient isolated from the roots of Stellera chamaejasme L. (Thymelaeaceae). Chamaechromone possesses *anti-hepatitis* B virus (HBV)** effects against the surface antigen of HBV (HBsAg) secretion and has insecticidal activities .

HY-126970

HBF-0259	HBV	Infection
HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC₅₀ of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis .

HY-Y0073

4-Hydroxyacetophenone P-hydroxyacetophenone	HBV Myosin	Infection Inflammation/Immunology Cancer
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .

HY-P4046

HBV Seq2 aa:179-186	HIV	Inflammation/Immunology
HBV Seq2 aa:179-186 serve as effective motifs for CTL response in H-2b system after in vitro restimulation of the primed T cells. HBV Seq2 aa:179-186 is a novel epitope identified on the surface antigen of hepatitis B virus .

HY-19447

Besifovir LB80331	HBV	Infection
Besifovir (LB80331), a parent agent converted by LB80380 (HY-19447A), further metabolizes to its active form, LB80317 (HY-106235). Besifovir is an orally active, novel antiviral agent against hepatitis B virus (HBV) .

HY-119691

Alamifovir LY582563; MCC-478	HBV	Infection
Alamifovir (LY582563; MCC-478), a purine nucleotide analogue proagent, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect .

HY-116999

IR415	HBV	Infection
IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (K_d=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease . HBx: hepatitis B virus X protein.

HY-156578

DGKα-IN-8	DGK HIV	Infection Cancer
DGKα-IN-8 (Example 51) is a DGKα inhibitor (IC₅₀=22.491 nM; EC₅₀=0.256 nM). DGKα-IN-8 can be used to study cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection .

HY-126970R

HBF-0259 (Standard)	HBV	Infection
HBF-0259 (Standard) is the analytical standard of HBF-0259. This product is intended for research and analytical applications. HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC50 of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis .

HY-Y0073R

4-Hydroxyacetophenone (Standard) P-hydroxyacetophenone (Standard)	Reference Standards HBV Myosin	Infection Inflammation/Immunology Cancer
4-Hydroxyacetophenone (Standard) is the analytical standard of 4-Hydroxyacetophenone. This product is intended for research and analytical applications. 4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .

HY-176507

DF-006	HBV	Infection Inflammation/Immunology
DF-006 is a first-in-class orally active agonist of ALPK1 (α-kinase 1). DF-006 can stimulate the innate immune response by activating the NF-κB pathway and strongly stimulate the innate immunity in the liver locally. DF-006 reduces the levels of serum HBV DNA (EC₅₀ = 2.7 pM), HBsAg and HBeAg, and has shown strong antiviral effects. DF-006 is suitable for research on the immunotherapy of chronic hepatitis B (CHB) .

HY-177022

ALG-001075	HBV	Infection
ALG-001075, a capsid assembly modulator (CAM), is an orally active HBV inhibitor. ALG-001075 effectively blocks not only HBV DNA production but also extracellular HBsAg/HBeAg and intracellular HBV RNA in primary human hepatocytes. ALG-001075 shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model. ALG-001075 can be used for the study of Chronic hepatitis B (CHB) .

HY-126033

Sophoranol	HBV RSV	Infection
Sophoranol is an alkaloid that can be isolated from S. flavescens, with antiviral activity. Sophoranol has anti-*HBV (hepatitis* B virus) activity. Sophoranol shows potent antiviral activities against respiratory syncytial virus (RSV) with an IC₅₀** of 10.4 μg/mL .

HY-113586

Besifovir Dipivoxil LB-80380	HBV DNA/RNA Synthesis Drug Derivative	Infection
Besifovir Dipivoxil (LB-80380), an analog of guanosine monophosphate, is an acyclic nucleotide phosphonate with antiviral effect. Besifovir Dipivoxil is rapidly converted by the liver and intestine to the intermediate metabolite LB80331 via the esterification process, subsequently phosphorylated into the di- and triphosphate forms, which act as antiviral DNA synthesis inhibitors. Besifovir Dipivoxil is promising for research of chronic hepatitis B .

HY-145713

GS-8873 HBV-IN-19	HBV	Infection
GS-8873 is an orally active inhibitor for the production of hepatitis B virus (HBV) surface antigen (HBsAg) with an EC₅₀ of 4 nM. GS-8873 exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 causes neurofunctional deficits in rats and cynomolgus monkeys .

HY-145713A

GS-8873 TFA HBV-IN-19 TFA	HBV	Infection
GS-8873 TFA is the TFA salt form of GS-8873 (HY-145713). GS-8873 TFA is an orally active inhibitor for the production of hepatitis B virus (HBV) surface antigen (HBsAg) with an EC₅₀ of 4 nM. GS-8873 TFA exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 TFA causes neurofunctional deficits in rats and cynomolgus monkeys .

HY-174856

PROTAC HBeAg degrader-1	PROTACs HBV	Infection
PROTAC HBeAg degrader-1 is a PROTAC targeting degradation agent for HBeAg. PROTAC HBeAg degrader-1 recruits the VHl E3 ligase but degrades HBV protein HBeAg through VHL-independent mechanism. PROTAC HBeAg degrader-1 decreases levels of secreted and intracellular HBeAg. PROTAC HBeAg degrader-1 can be used for the research of hepatitis B virus (HBV) . (Structure Note: Pink: HBeAg ligand (HY-174857); Blue: CRBN Ligand (HY-125845); Black: linker; E3-linker (HY-135045))

HY-W018791

Bifendate 1 Publications Verification DDB	HBV Autophagy Cytochrome P450 Atg8/LC3 p62 P-glycoprotein	Infection Cardiovascular Disease Cancer
Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .

HY-174297

HBV/HDV-IN-5	HBV	Infection
HBV/HDV-IN-5 (example 4) is an inhibitor of hepatitis B virus (HBV) and hepatitis D virus (HDV) .

HY-W753521

Deleobuvir sodium BI 207127 sodium	Endogenous Metabolite	Infection
Deleobuvir sodium (BI 207127 sodium) is a non-nucleoside hepatitis C virus NS5B polymerase inhibitor with anti-hepatitis C virus activity .

HY-145638

Xalnesiran	HBV	Infection
Xalnesiran is siRNA for the treatment of chronic hepatitis B (HBV).

HY-145638A

Xalnesiran sodium	HBV	Infection
Xalnesiran (sodium) is siRNA for the treatment of chronic hepatitis B (HBV)..

HY-147266

Elebsiran sodium VIR-2218 sodium	Small Interfering RNA (siRNA) HBV	Infection
Elebsiran sodium is a siRNA against hepatitis B and D virus infections .

HY-147266A

Elebsiran VIR-2218	HBV Small Interfering RNA (siRNA)	Infection
Elebsiran is a siRNA against hepatitis B and D virus infections .

HY-162327

PROTAC PAPD5 degrader 1	PROTACs HBV	Infection
PROTAC PAPD5 degrader 1 (compound 12b) inhibits both hepatitis A (HAV) and hepatitis B virus (HBV) in vitro and in vivo , with IC₅₀ and CC₅₀ of 10.59 μM and ＞ 50 μM, respectively in Huh7 cells .

HY-19447A

Besifovir Dipivoxil maleate LB80380 maleate	HBV	Infection
Besifovir Dipivoxil maleate (LB80380 maleate) is an oral proagent of LB80317. Besifovir Dipivoxil maleate (LB80380 maleate) is effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic hepatitis B (CHB) patients in preliminary studies ^[2]

HY-14775

Nesbuvir 5+ Cited Publications HCV-796	HCV	Infection
Nesbuvir is a nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase.

HY-13910A

Tenofovir hydrate 5+ Cited Publications GS 1278 hydrate; PMPA hydrate	HIV Reverse Transcriptase	Infection Cancer
Tenofovir hydrate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.

HY-N3861

Erythrocentaurin	HBV	Infection
Erythrocentaurin, a natural compound, is a new class of hepatitis B virus inhibitor .

HY-124600R

NVR 3-778 (Standard)	HBV	Infection
NVR 3-778 (Standard) is the analytical standard of NVR 3-778. This product is intended for research and analytical applications. NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator) belonging to the SBA (sulfamoylbenzamide) class, with anti-HBV activity .

Cat. No.	Product Name

HY-L113

Antiviral Traditional Chinese Medicine Active Compound Library

176 compounds

Increasing research have shown that Traditional Chinese Medicine (TCM) possess antiviral activities against various viral strains, such as herpes simplex virus, influenza virus, hepatitis B and C viruses, and SARS-CoV. To date, dozens of Chinese herbs and hundreds of natural TCM ingredients have been reported to exhibit good antiviral activities. Active components from TCM are one of the important sources for antiviral drugs discovery.

MCE designs a unique collection of 176 active compounds of antiviral Chinese Herbal Medicines. MCE Antiviral Traditional Chinese Medicine Active Compound Library is a useful tool for discovery antiviral drugs from TCM.

HY-L101

Anti-Liver Cancer Compound Library

2,383 compounds

Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.

Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc.

MCE offers a unique collection of 2,383 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Cat. No.	Product Name	Type

HY-137131

DC-Chol hydrochloride

DC-Cholesterol hydrochloride

Drug Delivery

DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

Cat. No.	Product Name	Target	Research Area

HY-P1774

Hepatitis B Virus Core (128-140)	HBV	Infection
Hepatitis B Virus Core (128-140) is a peptide of hepatitis B virus core protein.

HY-P4042

Hepatitis B Virus Receptor Binding Fragment hepatitis B peptide 4980	HBV	Infection Inflammation/Immunology
Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization .

HY-P4043

Hepatitis b virus pre-s region (120-145)	HBV	Infection Inflammation/Immunology
Hepatitis b virus pre-s region (120-145) is a preS2 peptide that inhibits the binding of single-chain Fv fragment (scFv) or IgG to r-HBsAg .

HY-P4038

Hepatitis C Virus S5A/5B	HCV Protease	Infection
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .

HY-P4041

*[Ala127] Hepatitis* B Virus Pre-S Region (120-131)**	Peptides	Others
[Ala127] Hepatitis B Virus Pre-S Region (120-131) is a peptide with the sequence of MQWNSTAFHQT. [Ala127] Hepatitis B Virus Pre-S Region (120-131) can be used in the activity enhancement study .

HY-P4051

HBV Seq1 aa:141-151	HBV	Infection Inflammation/Immunology
HBV Seq1 aa:141-151 is a peptide. HBV Seq1 aa:141-151 can be used for the research of chronic hepatitis B virus (HBV) .

HY-P4045

HBV Seq2 aa:208-216	HBV	Infection
HBV Seq2 aa:208-216, a HBsAg derived CD8 epitope peptide, is studied as part of Large envelope protein from Hepatitis B virus .

HY-P4046

HBV Seq2 aa:179-186	HIV	Inflammation/Immunology
HBV Seq2 aa:179-186 serve as effective motifs for CTL response in H-2b system after in vitro restimulation of the primed T cells. HBV Seq2 aa:179-186 is a novel epitope identified on the surface antigen of hepatitis B virus .

HY-P4049

HBV Seq1 aa:63-71	HBV	Infection
HBV Seq1 aa:63-71 is the fragment of hepatitis B virus (HBV) .

HY-P2783

Destruxin B2	HBV	Infection
Destruxin B2 (compound 5) is a natural depsipeptide that can be inhibits hepatitis B surface antigen (HBsAg) secretion in Hep3B cells with an IC₅₀ 1.30 μM .

HY-P4050

HBV Seq1 aa:18-27	HBV	Infection
HBV Seq1 aa:18-27 is a hepatitis B virus (HBV) core antigen 18-27 peptide fragment .

HY-P4048

HBV Seq1 aa:93-100	HBV	Infection
HBV Seq1 aa:93-100 is a hepatitis B virus (HBV) core antigen 93-100 peptide fragment .

HY-P4044

HBV Seq2 aa:28-39	HBV	Infection
HBV Seq2 aa:28-39 is a HBsAg peptide, which binds to major histocompatibility complex (MHC) class I molecules .

HY-P10056

HEP-1 Human ezrin peptide (324-337)	HIV HCV HPV Influenza Virus Interleukin Related	Infection Inflammation/Immunology
HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases .

Cat. No.	Product Name	Target	Research Area

HY-P99693

Lenvervimab GC1102	HBV	Infection
Lenvervimab (GC1102) is a IgG1-type recombinant human hepatitis B Immunoglobulin. Lenvervimab can be used for research of hepatitis B virus infection .

HY-P99608

Exbivirumab	HBV	Infection
Exbivirumab is an anti-HBV mAb. Exbivirumab enhances the antiviral activity of hepatitis B immunoglobulin (HBIG) .

HY-108842

Peginterferon alfa-2b PegIFN a-2b; Sch 54031; Sylatron; ViraferonPeg	HIV HCV	Infection Inflammation/Immunology Cancer
Peginterferon alfa-2b (PegIFN a-2b) is an immunomodulator. Peginterferon alfa-2b is a recombinant alfa-2b interferon covalently linked PEG. Peginterferon alfa-2b in decreasing viral DNA in HIV. Peginterferon alfa-2b can be used in research of melanoma and hepatitis C .

HY-P990015

Tobevibart VIR-3434	HBV	Infection
Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda1, Isotype Control (HY-P99992) .

HY-P99541

Tuvirumab anti-hepatitis B; OST 577; SDZ-OST 577	HBV	Infection
Tuvirumab (OST 577; SDZ-OST 577) is a human IgG1 subclass monoclonal antibody directed against HBV surface antigen (HBsAg). Tuvirumab binds specifically and with high affinity (K=3.6 nM) to HBsAg. Tuvirumab has the potential for chronic hepatitis B research .

HY-P991200

OM-7D3-B3	Claudin HCV	Infection
OM-7D3-B3 is a monoclonal antibody targeting human claudin-1 (CLDN1) (K_d = 4 nM). OM-7D3-B3 blocks the process in which CLDN1 is involved in the entry of hepatitis C virus (HCV) into cells. OM-7D3-B3 is promising for research of HCV infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-133721

Chamaechromone	Flavonoids Classification of Application Fields Thymelaeaceae Source classification Phenols Polyphenols Plants Biflavones Disease Research Fields Inflammation/Immunology Stellera chamaejasme L.	HBV
Chamaechromone is a biflavonoid ingredient isolated from the roots of Stellera chamaejasme L. (Thymelaeaceae). Chamaechromone possesses *anti-hepatitis* B virus (HBV)** effects against the surface antigen of HBV (HBsAg) secretion and has insecticidal activities .

HY-Y0073

4-Hydroxyacetophenone P-hydroxyacetophenone	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Compositae Inflammation/Immunology Disease Research Fields Artemisia capillaris Thunb.	HBV Myosin
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .

HY-N10543

5-O-(E)-p-Coumaroylquinic acid	Structural Classification Monophenols Phenols Spatholobus suberectus Dunn Plants Compositae	HBV
5-O-(E)-p-Coumaroylquinic acid, a quinic acid derivative, is a potent phytochemical agent against hepatitis B virus .

HY-N6939

Pseudolaric Acid B 1 Publications Verification	Infection Structural Classification Classification of Application Fields Pinaceae Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Cancer	HBV Fungal Apoptosis Autophagy Ferroptosis Interleukin Related HIF/HIF Prolyl-Hydroxylase
Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2 .

HY-Y0073R

4-Hydroxyacetophenone (Standard) P-hydroxyacetophenone (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Plants Compositae Artemisia capillaris Thunb.	Reference Standards HBV Myosin
4-Hydroxyacetophenone (Standard) is the analytical standard of 4-Hydroxyacetophenone. This product is intended for research and analytical applications. 4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .

HY-126033

Sophoranol	Infection Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Source classification Plants Sophora flavescens Aiton Disease Research Fields	HBV RSV
Sophoranol is an alkaloid that can be isolated from S. flavescens, with antiviral activity. Sophoranol has anti-*HBV (hepatitis* B virus) activity. Sophoranol shows potent antiviral activities against respiratory syncytial virus (RSV) with an IC₅₀** of 10.4 μg/mL .

HY-N3861

Erythrocentaurin	Structural Classification Natural Products Gentiana macrophylla Pall. Source classification Gentianaceae Plants	HBV
Erythrocentaurin, a natural compound, is a new class of hepatitis B virus inhibitor .

HY-P2783

Destruxin B2	Structural Classification Microorganisms Cyclopeptides Source classification	HBV
Destruxin B2 (compound 5) is a natural depsipeptide that can be inhibits hepatitis B surface antigen (HBsAg) secretion in Hep3B cells with an IC₅₀ 1.30 μM .

HY-N3093

Periglaucine B (+)-Periglaucine B	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Pericampylus glaucus (Lam.) Merr. Plants Menispermaceae	HBV
Periglaucine B ((+)-Periglaucine B) is an alkaloid and an HBsAg inhibitor. Periglaucine B can be isolated from Pericampylus glaucus. Periglaucine B inhibits the secretion of hepatitis B virus (HBV) surface antigen (HBsAg) in Hep G2.2.15 cells with an IC₅₀ of 0.47 mM .

HY-N12483

Catenulopyrizomicin A	Structural Classification Alkaloids Microorganisms Source classification Pyridine Alkaloids	HBV
Catenulopyrizomicin A has a thiazolyl pyridine moiety. Catenulopyrizomicin A can be isolated from the fermentation broth of rare actinomycete Catenuloplanes sp. Catenulopyrizomicin A has *anti-Hepatitis* B** virus activity .

HY-N6939R

Pseudolaric Acid B (Standard)	Structural Classification Pinaceae Terpenoids Diterpenoids Plants	Reference Standards HBV Fungal Apoptosis Autophagy Ferroptosis HIF/HIF Prolyl-Hydroxylase Interleukin Related
Pseudolaric Acid B (Standard) is the analytical standard of Pseudolaric Acid B. This product is intended for research and analytical applications. Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2 .

HY-W754691

Glaziovine	Structural Classification Alkaloids Other Alkaloids Source classification Plants Menispermaceae Hypserpa nitida Miers	HBV
Glaziovine is an antiviral agent found in Hypserpa nitida. Glaziovine exhibits significant inhibitory activity against HBV, capable of suppressing hepatitis B virus surface antigen (HBsAg) secretion in Hep G2.2.15 cells transfected with HBV, with an IC₅₀ of 8 nM .

HY-W060316

β-Thujaplicinol 3-Hydroxy-5-isopropyltropolone	Structural Classification Cupressaceae Ketones, Aldehydes, Acids Source classification Plants	HBV DNA/RNA Synthesis
β-Thujaplicinol (3-Hydroxy-5-isopropyltropolone) is an inhibitor of hepatitis B virus (HBV) ribonuclease H. β-Thujaplicinol inhibits RNAseHs of HBV genotypes D and H with IC₅₀ values of 5.9 and 2.3 μM, respectively .

HY-N0854

Alisol F	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Alisma orinentale (Samuel.) Juz. Plants Alismataceae Disease Research Fields	HBV
Alisol F is a triterpene isolated from Alisma orinentale, has immunosuppressive and anti-virus functions. Alisol F exhibits inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the HepG2.2.15 cell line with an IC₅₀ of 0.6 μM .

HY-N7121

Erythromycin estolate 1 Publications Verification	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Antibiotic Bacterial Aminotransferases (Transaminases) Flavivirus Dengue Virus
Erythromycin estolate is the Erythromycin (HY-B0220) derivative , is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin estolate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin estolate toxicity is related to its inhibitory effect on bile acid transport .

HY-B1192

Estradiol benzoate Maximum Cited Publications 15 Publications Verification β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Classification of Application Fields Disease Research Fields Cancer	Estrogen Receptor/ERR HBV Bcl-2 Family
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-N0639

Punicalin	Structural Classification Punica granatum L. Classification of Application Fields Source classification Phenols Polyphenols Punicaceae Plants Inflammation/Immunology Disease Research Fields	HBV Pyroptosis Carbonic Anhydrase
Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .

HY-N12105

Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Illicium henryi Diels.	HBV
Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside is an anti-hepatitis B virus (anti-HBV) agent. Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside inhibits HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion on Hep G2.2.15 cell line, with IC₅₀ values of 1.67 and >2.15 mM, respectively .

HY-N0063

Punicalagin 5+ Cited Publications	Infection Structural Classification Punica granatum L. Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Punicaceae Plants Disease Research Fields	SARS-CoV HBV
Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CL ^pro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an *anti-hepatitis* B virus (HBV)** agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .

HY-N7121R

Erythromycin estolate (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Antibiotics Source classification Antibacterial Disease Research	Antibiotic Reference Standards Bacterial Aminotransferases (Transaminases) Flavivirus Dengue Virus
Erythromycin estolate (Standard) is the analytical standard of Erythromycin estolate. This product is intended for research and analytical applications. Erythromycin estolate is the Erythromycin (HY-B0220) derivative , is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin estolate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin estolate toxicity is related to its inhibitory effect on bile acid transport .

HY-N0063R

Punicalagin (Standard)	Structural Classification Punica granatum L. Source classification Phenols Polyphenols Punicaceae Plants	Reference Standards SARS-CoV HBV
Punicalagin (Standard) is the analytical standard of Punicalagin. This product is intended for research and analytical applications. Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .

HY-N0639R

Punicalin (Standard)	Structural Classification Punica granatum L. Source classification Phenols Polyphenols Punicaceae Plants	Reference Standards HBV Pyroptosis Carbonic Anhydrase
Punicalin (Standard) is the analytical standard of Punicalin. This product is intended for research and analytical applications. Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .

HY-N0058

4,5-Dicaffeoylquinic acid 5+ Cited Publications Isochlorogenic acid C	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Bowdichia virgilioides Plants Compositae Endogenous metabolite Disease Research Fields	HBV Endogenous Metabolite Apoptosis Glycosidase
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-N0853

Alisol A 4 Publications Verification	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Source classification Other Diseases Alismataceae Plants Disease Research Fields	AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related
Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .

HY-N0058R

4,5-Dicaffeoylquinic acid (Standard) Isochlorogenic acid C (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Bowdichia virgilioides Plants Compositae Endogenous metabolite	Reference Standards HBV Endogenous Metabolite Apoptosis Glycosidase
4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-N0853R

Alisol A (Standard)	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Terpenoids Source classification Alismataceae Plants	Reference Standards AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related
Alisol A (Standard) is the analytical standard of Alisol A (HY-N0853). This product is intended for research and analytical applications. Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .

Species:	Virus (5) Human (5)
Tag:	His (8) Tag Free (3) Avi (3)
Source:	HEK293 (5) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P74354

	*Capsid protein, Hepatitis* B Virus (His)** 1 Publications Verification Capsid protein; Core antigen; C protein; HBcAg; hepatitis B Virus (HBV)(ayw/France/Tiollais/1979)	Virus	E. coli
	Capsid proteins play a key role in the assembly of icosahedral capsids, forming T=4 and T=3 particles. Transported along microtubules to the nucleus, its phosphorylation exposes a nuclear localization signal that promotes binding to nuclear pore complexes via α and β import. Capsid protein, Hepatitis B Virus (His) is the recombinant Virus-derived Capsid protein, expressed by E. coli , with C-His labeled tag.

HY-P702127

	*POLG Protein, Hepatitis* C virus genotype 1b** Genome polyprotein	Virus	E. coli
	POLG proteins play multiple roles in the viral life cycle, contributing to viral RNA packaging, budding, and particle production. It exhibits RNA-binding and RNA chaperone activities, affecting translation initiation through interactions with viral IRES and ribosomal subunits. POLG Protein, Hepatitis C virus genotype 1b is the recombinant Virus-derived POLG protein, expressed by E. coli , with tag free.

HY-P702128

	*POLG Protein, Hepatitis* C virus genotype 1b (His)** Genome polyprotein	Virus	E. coli
	POLG proteins play multiple roles in the viral life cycle, contributing to viral RNA packaging, budding, and particle production. It exhibits RNA-binding and RNA chaperone activities, affecting translation initiation through interactions with viral IRES and ribosomal subunits. POLG Protein, Hepatitis C virus genotype 1b (His) is the recombinant Virus-derived POLG protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700912

	*HLA-A0201 HBV Complex Protein, Human (FLLTRILTI, HEK293, His-Avi)** hepatitis B virus	Human	HEK293
	The HLA-A0201 MAGE-A4 complex protein is a member of the major histocompatibility complex (MHC) class I family. HLA-A0201 HBV Complex Protein, Human (FLLTRILTI, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 HBV Complex protein, expressed by HEK293, with C-Avi, C-His labeled tag. HLA-A0201 HBV Complex Protein, Human (FLLTRILTI, HEK293, His-Avi), has molecular weight of 52-62 kDa.

HY-P700911

	*HLA-A0201 HBV Complex Protein, Human (Biotinylated, FLLTRILTI, HEK293, His-Avi)** hepatitis B virus	Human	HEK293
	The HLA-A0201 MAGE-A4 complex protein is a member of the major histocompatibility complex (MHC) class I family. HLA-A0201 HBV Complex Protein, Human (Biotinylated, FLLTRILTI, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 HBV Complex protein, expressed by HEK293, with C-Avi, C-His labeled tag. HLA-A0201 HBV Complex Protein, Human (Biotinylated, FLLTRILTI, HEK293, His-Avi), has molecular weight of 52-62 kDa.

HY-P700913

	*HLA-A0201 HBV Complex Tetramer Protein, Human (FLLTRILTI, HEK293, His-Avi)** hepatitis B virus	Human	HEK293
	The HLA-A0201 MAGE-A4 complex protein is a member of the major histocompatibility complex (MHC) class I family. HLA-A0201 HBV Complex Tetramer Protein, Human (FLLTRILTI, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 HBV Complex Tetramer protein, expressed by HEK293, with C-Avi, C-His labeled tag. HLA-A0201 HBV Complex Tetramer Protein, Human (FLLTRILTI, HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P74183

	*E2/Envelope Protein, Hepatitis* C virus (AAC15723, HEK293, His)** HCV-1a E2 Protein; hepatitis C virus (serotype 1b, isolate HC-J4) Envelope/E2 Protein	Virus	HEK293
	E2/Envelope Protein, Hepatitis C virus (AAC15723, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293, with C-His labeled tag.

HY-P74899

	Envelope Glycoprotein E1 Protein, HCV (HEK293, His) HCV-E1 Protein; hepatitis C virus Envelope Glycoprotein E1 / HCV-E1 (subtype 1b, strain HC-J4) Protein	Virus	HEK293
	Envelope Glycoprotein E1 Protein, one of two subunits of the envelope glycoprotein found in the hepatitis C virus, is a type 1 transmembrane protein.It associates with envelope glycoprotein E2 as a noncovalent heterodimer, which mediates virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane.E1/E2 heterodimer binds host apolipoproteins.And it also binds to CD81 and activates the epithelial growth factor receptor (EGFR) signaling pathway.Envelope Glycoprotein E1 Protein, HCV (HEK293, His) is the recombinant Virus-derived Envelope Glycoprotein E1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P703547

	HCVNS5B Protein, HCV Genome polyprotein; hepatitis C virus genotype 1b (strain HC-J4); HCV; p23; Helicase; Hydrolase; Ion channel; Multifunctional enzyme; Nucleotidyltransferase; Protease; Ribonucleoprotein; RNA-binding; RNA-directed RNA polymerase; Serine protease; Thiol protease; Transferase; Viral ion channel; Viral nucleoprotein	Others	E. coli
	POLG proteins play multiple roles in the viral life cycle, contributing to viral RNA packaging, budding, and particle production. It exhibits RNA-binding and RNA chaperone activities, affecting translation initiation through interactions with viral IRES and ribosomal subunits. HCVNS5B Protein, HCV is the recombinant HCVNS5B, expressed by E. coli, with tag Free labeled tag.

HY-P702076

	RBCK1 Protein, Human RBCK1; RanBP-type and C3HC4-type zinc finger-containing protein 1; HBV-associated factor 4; Heme-oxidized IRP2 ubiquitin ligase 1; HOIL-1; hepatitis B virus X-associated protein 4; RING finger protein 54; RING-type E3 ubiquitin transferase HOIL-1; Ubiquitin-conjugating enzyme 7-interacting protein 3	Human	E. coli
	RBCK1 is an E3 ubiquitin protein ligase that cooperates with specific E2 enzymes such as UBE2L3/UBCM4 to transfer ubiquitin to substrates. It acts as an E3 ligase that oxidizes IREB2, relying on heme and oxygen for IREB2 ubiquitination. RBCK1 Protein, Human is the recombinant human-derived RBCK1 protein, expressed by E. coli , with tag free.

HY-P702077

	RBCK1 Protein, Human (His) RBCK1; RanBP-type and C3HC4-type zinc finger-containing protein 1; HBV-associated factor 4; Heme-oxidized IRP2 ubiquitin ligase 1; HOIL-1; hepatitis B virus X-associated protein 4; RING finger protein 54; RING-type E3 ubiquitin transferase HOIL-1; Ubiquitin-conjugating enzyme 7-interacting protein 3	Human	E. coli
	RBCK1 is an E3 ubiquitin protein ligase that cooperates with specific E2 enzymes such as UBE2L3/UBCM4 to transfer ubiquitin to substrates. It acts as an E3 ligase that oxidizes IREB2, relying on heme and oxygen for IREB2 ubiquitination. RBCK1 Protein, Human (His) is the recombinant human-derived RBCK1 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-113904S

(Rac)-Tenofovir-d6
(Rac)-Tenofovir-d₆ is a labelled racemic Tenofovir. Tenofovir (GS 1278) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV) .

HY-15602S

Ledipasvir-d6
Ledipasvir-d₆ is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC₅₀s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.62 μM .

HY-W654247

Lamivudine-13C,d2
Lamivudine- ¹³C,d₂ is the deuterium labeled and ¹³C-labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-124592

BMT-052
BMT-052 is a pan-genotypic hepatitis C (HCV) NS5B polymerase primer grip inhibitor .

HY-B0017S

Telbivudine-d4
Telbivudine-d₄ is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication .

HY-135330

Lamivudine-13C,15N2
Lamivudine- ¹³C, ¹⁵N₂ is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus .

HY-B0250S

Lamivudine-15N,d2
Lamivudine- ¹⁵N,d₂ is ¹⁵N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-15602AS

Ledipasvir-d6 hydrochloride
Ledipasvir-d₆ hydrochloride is deuterated labeled Ledipasvir acetone (HY-15602A). Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

HY-15602S1

Ledipasvir-d16
Ledipasvir-d₁₆ (GS-5885-d₁₆) is deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC₅₀s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.62 μM .

HY-B0250S1

Lamivudine-13C,15N2,d2
Lamivudine-13C,15N2,d2 (BCH-189-13C,15N2,d2) is a 13C, 15N, and deuterium labeled Lamivudine (HY-B0250). Lamivudine is an orally active and blood-brain barrier permeable nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus (HBV) reverse transcriptase .

HY-B0250S2

Lamivudine-13C,15N3
Lamivudine- ¹³C, ¹⁵N₃ (BCH-189- ¹³C, ¹⁵N₃) is ¹³C and ¹⁵N labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-B0442AS

Vardenafil-d5 hydrochloride

Vardenafil-d₅ hydrochloride is deuterated labeled Vardenafil hydrochloride (HY-B0442A). Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC₅₀ of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC₅₀s of 180 nM, and 11 nM, while IC₅₀s are >1000 nM for PDE3 and PDE4 . Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels . Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes ^[1]-[6].

HY-W713297

Moroxydine hydrochloride-d8

Moroxydine hydrochloride-d₈ (ABOB hydrochloride-d₈) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels ^[1][2][3].

Cat. No.	Product Name		Classification

HY-121513

Torcitabine 2'-Deoxy-L-cytidine; L-dC		Nucleosides and their Analogs C
Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection treatment .

HY-145638A

Xalnesiran sodium		siRNAs siRNA drugs
Xalnesiran (sodium) is siRNA for the treatment of chronic hepatitis B (HBV)..

HY-147266

Elebsiran sodium VIR-2218 sodium		siRNAs siRNA drugs
Elebsiran sodium is a siRNA against hepatitis B and D virus infections .

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride		Cholesterol
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-W105601

5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine		Nucleosides and their Analogs C
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine (2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine) is an antiviral compound that inhibits HBV reverse transcriptase activity. 5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine shows potential to control HBV replication in vitro. 5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine, as a nucleoside analog, may provide a new option for the suppression of chronic hepatitis B .

HY-W352344

2'-Deoxy-L-adenosine		Nucleosides and their Analogs A
2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV) .

HY-145638

Xalnesiran		siRNAs siRNA drugs
Xalnesiran is siRNA for the treatment of chronic hepatitis B (HBV).

HY-148171

L-2'-Fd4C		Nucleosides and their Analogs C
L-2'-Fd4C, is an l-nucleoside analogue. L-2'-Fd4C has anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity .

HY-148172

L-Fd4A		Nucleosides and their Analogs A
L-Fd4A is an adenine derivative. L-Fd4A has anti-human immunodeficiency virus (HIV) (EC₅₀=1.5 μM) and anti-hepatitis B virus (HBV) (EC₅₀=1.7 μM) activity. L-Fd4A has low cytotoxicity .

HY-148089

Eplontersen		Antisense Oligonucleotides
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-148089A

Eplontersen sodium		Antisense Oligonucleotides
Eplontersen sodium the sodium salt form of Eplontersen (HY-148089). Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

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