1. Anti-infection
  2. HBV
  3. ALG-000184

ALG-000184, a prodrug of the potent Hhepatitis B virus (HBV) capsid assembly modulator ALG-001075, has the potential for the research of HBV infection research.

For research use only. We do not sell to patients.

ALG-000184 Chemical Structure

ALG-000184 Chemical Structure

CAS No. : 2495324-72-4

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Based on 1 publication(s) in Google Scholar

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Description

ALG-000184, a prodrug of the potent Hhepatitis B virus (HBV) capsid assembly modulator ALG-001075, has the potential for the research of HBV infection research[1].

Clinical Trial
Molecular Weight

576.38

Formula

C23H20FN4Na2O8P

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CC1=C(C(NC2=CC=C(F)C(C#N)=C2)=O)N(C)C(C)=C1C(C(N(C3(C#C)COC3)COP(O[Na])(O[Na])=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 116.67 mg/mL (202.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7350 mL 8.6748 mL 17.3497 mL
5 mM 0.3470 mL 1.7350 mL 3.4699 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7350 mL 8.6748 mL 17.3497 mL 43.3742 mL
5 mM 0.3470 mL 1.7350 mL 3.4699 mL 8.6748 mL
10 mM 0.1735 mL 0.8675 mL 1.7350 mL 4.3374 mL
15 mM 0.1157 mL 0.5783 mL 1.1566 mL 2.8916 mL
20 mM 0.0867 mL 0.4337 mL 0.8675 mL 2.1687 mL
25 mM 0.0694 mL 0.3470 mL 0.6940 mL 1.7350 mL
30 mM 0.0578 mL 0.2892 mL 0.5783 mL 1.4458 mL
40 mM 0.0434 mL 0.2169 mL 0.4337 mL 1.0844 mL
50 mM 0.0347 mL 0.1735 mL 0.3470 mL 0.8675 mL
60 mM 0.0289 mL 0.1446 mL 0.2892 mL 0.7229 mL
80 mM 0.0217 mL 0.1084 mL 0.2169 mL 0.5422 mL
100 mM 0.0173 mL 0.0867 mL 0.1735 mL 0.4337 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ALG-000184 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ALG-000184
Cat. No.:
HY-169993
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