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Results for "

cytotoxic compound

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (3) ADC Linker (2) ADC Payload (7) Adrenergic Receptor (1) Akt (4) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (4) Aminoacyl-tRNA Synthetase (1) AMPK (2) Amylases (1) Amyloid-β (6) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (7) Antifolate (1) Apoptosis (73) ATM/ATR (2) ATP Synthase (1) Aurora Kinase (3) Autophagy (11) Bacterial (66) Bcl-2 Family (4) Bcr-Abl (3) Biochemical Assay Reagents (5) Btk (1) c-Met/HGFR (3) c-Myc (2) Calcium Channel (2) CaMK (2) Cannabinoid Receptor (1) Carbonic Anhydrase (6) Caspase (10) Cathepsin (2) CDK (17) Cholinesterase (ChE) (14) COX (1) CXCR (3) Cytochrome P450 (5) Dihydrofolate reductase (DHFR) (2) Dihydroorotate Dehydrogenase (3) DNA Alkylator/Crosslinker (1) DNA Stain (1) DNA/RNA Synthesis (12) Drug Derivative (10) Drug Intermediate (3) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) DYRK (2) E1/E2/E3 Enzyme (2) EGFR (20) Endogenous Metabolite (9) Endothelin Receptor (1) Enterovirus (3) Ephrin Receptor (1) Epigenetic Reader Domain (2) ERK (1) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (2) FAK (4) Farnesyl Transferase (2) Ferroptosis (7) FGFR (1) Flavivirus (3) FLT3 (1) Fluorescent Dye (2) FOXO (1) Fungal (20) G-quadruplex (1) GABA Receptor (1) GLUT (1) Glutathione Peroxidase (2) Glutathione S-transferase (1) Glycosidase (4) GPR84 (1) HCV (3) HDAC (7) Hedgehog (3) Hepatitis E Virus (HEV) (1) Herbicide (1) HIF/HIF Prolyl-Hydroxylase (4) Histone Acetyltransferase (1) Histone Demethylase (1) Histone Methyltransferase (4) HIV (21) HIV Protease (1) HSP (2) HSV (1) ICMT (1) iGluR (1) Influenza Virus (19) Integrin (1) Interleukin Related (2) IRAK (1) JAK (2) JNK (1) Keap1-Nrf2 (4) Kinesin (1) Lipoxygenase (1) MDM-2/p53 (2) Microtubule/Tubulin (21) Mitochondrial Metabolism (2) Mitosis (1) Mixed Lineage Kinase (1) MMP (2) Molecular Glues (1) Monoamine Oxidase (5) Monocarboxylate Transporter (1) mTOR (2) NAMPT (4) Necroptosis (4) NF-κB (4) NO Synthase (3) Nucleoside Antimetabolite/Analog (2) Orexin Receptor (OX Receptor) (2) P-glycoprotein (4) p38 MAPK (4) p62 (1) Paraptosis (1) Parasite (24) PARP (8) PD-1/PD-L1 (3) PDI (1) Phosphatase (1) Phosphodiesterase (PDE) (2) Photosensitizer (1) PI3K (3) PI4K (1) Pim (7) PKC (2) Polo-like Kinase (PLK) (1) Potassium Channel (3) PPAR (4) PROTACs (5) Quinone Reductase (1) RANKL/RANK (1) Ras (4) Reactive Oxygen Species (ROS) (13) Reference Standards (9) Reverse Transcriptase (2) RIP kinase (1) ROCK (2) ROR (2) ROS Kinase (1) RSV (5) SARS-CoV (23) Sec61 (1) Sigma Receptor (2) Small Interfering RNA (siRNA) (1) Src (2) STAT (4) Thymidylate Synthase (10) TNF Receptor (5) Toll-like Receptor (TLR) (1) Topoisomerase (14) Trk Receptor (1) TrxR (1) Tyrosinase (6) ULK (1) URAT1 (2) VEGFR (13) Virus Protease (5) YAP (1) β-catenin (1)
By Research Areas:	Cancer (346) Cardiovascular Disease (6) Infection (181) Inflammation/Immunology (41) Metabolic Disease (14) Neurological Disease (36)
Click Chemistry:	Azide (4) Alkynes (3)
Oligonucleotides:	Adjuvant (1)

628

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

122

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: CTLA-4

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115683

NUN82647	Apoptosis	Cancer
NUN82647 is a potent cytotoxic compound that inhibits cell cycle at G2 phase and induces apoptosis. NUN82647 can be used for the study of leukemia .

HY-N9003

Dihydroprehelminthosporol	Others	Cancer
Dihydroprehelminthosporol (Compound 1) from the fungusVeronaea sp.of the separated. Dihydroprehelminthosporol on human cancer cell line A549 and SK-0A-3 has cytotoxicity .

HY-174271

Antioxidant agent-21	Apoptosis	Cancer
Antioxidant agent-21 (Compound 9) is a phenolic heterocyclic compound with antioxidant and anticancer activities. Antioxidant agent-21 shows significant cytotoxicity toward human gastric adenocarcinoma (AGS) and lung cancer (A549) cells. Antioxidant agent-21 induces caspase-dependent apoptosis in cancer cells .

HY-N12989

3′-O-Demethylarctigenin	Others	Others
3′-O-Demethylarctigenin is a phenolic compound that can be isolated from the seeds of Arctium lappa. 3′-O-Demethylarctigenin shows cytotoxicity for PANC-1 cells with an IC₅₀ value of 4.38 µM .

HY-N10542

Aplyronine C	Others	Cancer
Aplyronine C is an active compound. Aplyronine C shows potent antitumor activity and has cytotoxicity against HeLa-S3 cells with an IC₅₀ values of 22 nM. Aplyronine C can be used for the research of cancer .

HY-N10541

Aplyronine B	Others	Cancer
Aplyronine B is an active compound. Aplyronine B shows potent antitumor activity and has cytotoxicity against HeLa-S3 cells with an IC₅₀ values of 2.9 nM. Aplyronine B can be used for the research of cancer .

HY-N10538

Shishijimicin B	Others	Cancer
Shishijimicin B is an *active compound* of the enediyne class*. Shishijimicin B shows extremely potent cytotoxicity* with IC₅₀ values of 2.0-3.3 nM. Shishijimicin B has antitumor activity and can be used for the research of cancer . Shishijimicin B is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N6582

Flavokawin C	Others	Cancer
Flavokawin C is a natural compound with antioxidative and cytotoxicity .

HY-N12122

Dehydropipernonaline	Fungal	Neurological Disease
Dehydropipernonaline (Compound 24) is an amide compound. Dehydropipernonaline shows considerable cytotoxicity to L5178Y mouse lymphoma cells (IC₅₀8.9μM). Dehydropipernonaline can be used for screening antifungal and cytotoxicity .

HY-165097

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC 15(S)-HpETE-SAPC; 15(S)-Hydroperoxyeicostetraenoic acid-SAPC	Reactive Oxygen Species (ROS)	Others
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC (15(S)-HpETE-SAPC) is a compound studied for the cytotoxicity of phosphatidylcholine hydroperoxides. Its cytotoxicity is exerted through the decomposition of hydroperoxides to produce toxic compounds.

HY-130418

(-)-Domesticine	Adrenergic Receptor	Cancer
(-)-Domesticine is an anti-α-1D-adrenoceptor compound with cytotoxic activity. (-)-Domesticine showed activity in MTS cytotoxicity assays against human colon cancer cell lines HCT-116 and Caco-2. (-)-Domesticine tolerates alkoxy substituents and benzoate functional groups at the C1 position in modifications of its chemical structure. The most potent compounds of (-)-Domesticine have IC50 values in the range of 23-38 μM, similar to the known cytotoxic compound etoposide .

HY-N3969

Goniotriol (+)-Goniotriol	Others	Others
Goniotriol(compound 2) is a styrylpyronethat can be found in Goniothalamus amuyon. Goniotriolshows cytotoxicity .

HY-N10796

Miltipolone	Others	Others
Miltipolone is a potent cytotoxic compound isolated from the fresh roots of Salvia divinorum .

HY-N8988

3-Methoxymollugin	Others	Others
3-methoxymollugin is a compound that can be isolated from Rubia cordifolia and is cytotoxic ..

HY-160473

TAM557	ADC Payload Microtubule/Tubulin	Cancer
TAM557 is a cytotoxic tubulysin compound that can be used in enzymatic conjugation reactions .

HY-N8915

Deoxyflindissone	Others	Others
Deoxyflindissone (Compound 13) is a triterpenoid compound. Deoxyflindissone is isolated from natural Cornus walteri .Deoxyflindissone has significant cytotoxic activity .

HY-N1148

Tinospinoside C 8-Hydroxytinophylloloside; 8-epi-Tinospinoside B	Others	Others
Tinospinoside C (compound 5) is a diterpene. Tinospinoside C has *cytotoxic* and antifouling activities .

HY-N12730

Euphoscopin B	Others	Others
Euphoscopin B (compound 5) is a cytotoxic macrocyclic diterpene isolated from Euphorbia helioscopia L .

HY-123724

Ravidomycin	Others	Others
Ravidomycin is a compound with antibacterial and cytotoxic activities. New analogs have been isolated from microorganisms. These analogs differ in antibacterial selectivity compared with known compounds.

HY-N3630

Coronarin D	Others	Others
Coronarin D is a cytotoxic labdan-type diterpenes compound isolated from the rhizomes of H. coronarium .

HY-128498

Anticancer agent 182	Others	Cancer
Anticancer agent 182 (Compound 1) is a cytotoxic flavonoid compound isolated from the root ofMuntingia colabura L. Anticancer agent 182 exhibits anticancer activity .

HY-147806

Antiparasitic agent-8	Parasite	Infection
Antiparasitic agent-8 (Compound 9) is an antiparasitic agent against Hymenolepis nana with low cytotoxicity .

HY-163558

Anticancer agent 212	Others	Cancer
Anticancer agent 212 (compound 10a) is a potent anticancer agent. Anticancer agent 212 shows cytotoxicity ^[1]

HY-N7256

Dihydrocephalomannine	Microtubule/Tubulin	Cancer
Dihydrocephalomannine (compound 1b), an analogue of Paclitaxel, shows reduced cytotoxicity and tubulin binding compared to Paclitaxel .

HY-N3800

Eichlerialactone	Others	Cancer
Eichlerialactone is a sesquiterpene compound isolated from Chisocheton penduliflorus. Eichlerialactone is weakly cytotoxic to breast cancer cells .

HY-N11572

Anticancer agent 96	Others	Cancer
Anticancer agent 96 (Compound 4) is an anticancer agent that shows cytotoxic activities against human cancer cells .

HY-N9186

Bakkenolide Db	Others	Others
Bakkenolide Db is a compound that can be isolated from the root of Petasites formosanus. Bakkenolide Db may have cytotoxicity .

HY-N15414

Demethoxykanugin Desmethoxykanugin	Cholinesterase (ChE)	Neurological Disease Cancer
Demethoxykanugin (Desmethoxykanugin, compound 1) is a acetylcholine (AChE) inhibitor. Demethoxykanugin shows cell cytotoxicity agains Vero cells .

HY-N12192

Ebenifoline E-II	Others	Others
Ebenifoline E-II (Compound 2) is a sesquiterpene alkaloid derived from Euonymus laxiflorus. Ebenifoline E-II is cytotoxic .

HY-168127

VEGFR-2-IN-57	VEGFR	Cancer
VEGFR-2-IN-57 (compound 6n) exhibited significant cytotoxicity in HUVEC cells (IC50 = 28.77 nM).

HY-155595

SNM1A-IN-1	DNA/RNA Synthesis	Others
SNM1A-IN-1 (compound 11a) is an inhibtor of SNM1A (a DNA damage repair enzyme with cytotoxicity) .

HY-N3448

Isowigtheone	Others	Cancer
Isowigtheone is a cytotoxic isoflavone compound isolated from the root barks of Brosimum utile. Isowigtheone has the potential for the research of cancer diseases .

HY-101280

LB-60-OF61	NAMPT	Cancer
LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines .

HY-76665

Anticancer agent 209	Drug Derivative	Cancer
Anticancer agent 209 (compound 1) is an anticancer agent. Anticancer agent 209 exhibits cytotoxic activity against colon cancer in vitro .

HY-N4189

Isocucurbitacin B	Others	Cancer
Isocucurbitacin B is a potent cytotoxic compound isolated from Helicteres rswa L. (Sterculiaceae). Isocucurbitacin B possesses anti-tumor acticity .

HY-162560

Antitumor agent-162	Others	Cancer
Antitumor agent-162 (compound 52a) is a potent and orally active antitumor agent. Antitumor agent-162 shows cytotoxicity .

HY-100044

SR 4330 1,2,4-Benzotriazin-3-amine; Win 60109	DNA/RNA Synthesis	Others
SR 4330 is a cytotoxic compound that targets hypoxic cells. The lower limits of quantification are 40 ng/mL and 20 ng/mL in mouse and human plasma .

HY-N1081A

Viteralone (S)-Viteralone	Others	Cancer
Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

HY-N12524

Cyclo(prolyltyrosyl)	Bacterial	Infection Cancer
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .

HY-163755

GPER activator 1	Estrogen Receptor/ERR	Inflammation/Immunology
GPER activator 1 (compound 6-26) is a GPER-selective compound without cytotoxicity. GPER activator 1 exhibits dual inhibition of TNFα- and IL-6-induced inflammation .

HY-128926

SPP N-succinimidyl 4-(2-pyridyldithio) pentanoate	ADC Linker	Cancer
SPP (N-succinimidyl 4-(2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate .

HY-N5007

Galgravin	Apoptosis	Cancer
Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells .

HY-100005A

Fumarate hydratase-IN-2 sodium salt 1 Publications Verification	Mitochondrial Metabolism	Cancer
Fumarate hydratase-IN-2 sodium salt (compound 3) is a cell-permeable and competitive fumarate hydratase inhibitor (K_i=4.5 μM) with nutrient-dependent cytotoxicity .

HY-155734

SARS-CoV-2-IN-55	SARS-CoV	Infection
SARS-CoV-2-IN-55(compound 65) is a low cytotoxicity inhibtor of SARS-CoV-2 with an IC₅₀ value of 0.3 μM, by the direct interaction with VSV-S pseudoparticles .

HY-B0139

Flucytosine 3 Publications Verification 5-Fluorocytosine; NSC 103805; Ro 2-9915	Fungal Antibiotic	Infection Cancer
Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells .

HY-N11015

Withaphysalin R	Others	Infection Inflammation/Immunology Cancer
Withaphysalin R (compound 5) is a Withanolide that can be isolated from the Solanaceae. Withanolide is a steroid ester with an ergosterol skeleton, and some of these compounds have some significant activities, including cytotoxic and immunosuppressive, antitumor, anti-inflammatory, anticonvulsive, and antioxidant .

HY-162392

Anticancer agent 203	Others	Cancer
Anticancer agent 203 (compound 27) is an anticancer agent. Anticancer agent 203 shows cytotoxicity. Anticancer agent 203 has the potential for the research of hepatoma .

HY-146348

Tuberculosis inhibitor 5	Bacterial	Infection
Tuberculosis inhibitor 5 (Compound 11i) is a potent antimycobacterial biphenyl analogue without noticeable cytotoxicity. Tuberculosis inhibitor 5 is an anti-tuberculosis agent .

HY-149003

PARP1-IN-10	PARP Apoptosis	Cancer
PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC₅₀ value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) .

HY-155278

Anticancer agent 162	Others	Cancer
Anticancer agent 162 (compound 1d) is an effective anticancer theranostic agent. Anticancer agent 162 induces oncosis of Hela cells with lipophilicity and cytotoxicity selectivity .

Cat. No.	Product Name

HY-L213

Anti-Cancer Approved Drug Library

277 compounds

The anti-cancer drug library meticulously collects all drugs approved by FDA and other major national drug regulatory authorities for cancer treatment. These drugs cover a variety of cancer types, including but not limited to lung cancer, breast cancer, colorectal cancer, leukemia, and other common cancers. The library includes a wide range of drugs, from classic chemotherapeutic agents to cutting-edge targeted therapies and immunotherapies. It contains various types of drug compounds with different mechanisms of action. There are cytotoxic drugs that directly kill cancer cells, as well as drugs that work by modulating the tumor microenvironment, inhibiting tumor angiogenesis, and activating the immune system. This diversity provides researchers with a broad range of perspectives and options for intervention strategies.

This library can be used for basic research on cancer treatment, exploring new targets and new mechanisms of drug action; Conducting drug reuse research to look for potential therapeutic effects of existing drugs on other cancer types or diseases; Or conducting research into combination drugs to optimize cancer treatment.

MCE has collected 277 small-molecule compounds with cancer indications, which are good tools for drug repurposing.

HY-L133

Cuproptosis Compound Library

298 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 298 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Type

HY-156087G

Cholicamideβ (GMP)	Fluorescent Dye
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .

HY-D2476

H2S Fluorescent probe 1	Fluorescent Dyes/Probes
H2S Fluorescent probe 1 (Compound 2) is a fluorescent probe that detects hydrogen sulfide (H₂S) with almost no cytotoxicity. Upon the addition of increasing amounts of HS ^- to DMSO solution of H2S Fluorescent probe 1, a new absorption peak appears gradually at 485 nm. H2S Fluorescent probe 1, the fluorescence intensity notes at 434 nm increasing rapidly by titration of HS ^- .

HY-D2380

H2S probe 1	Fluorescent Dyes/Probes
H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC₅₀=77.9 nM) and has a high affinity for human telomeric G-quadruplex (G4) (K_d=1.72 μM). H2S probe 1 can be used in cancer research .

Cat. No.	Product Name	Type

HY-Y0030A

3-Hydroxypicolinic acid, matrix substance for MALDI-MS

3-HPA

Biochemical Assay Reagents

3-Hydroxypicolinic acid, matrix substance for MALDI-MS is a matrix. 3-Hydroxypicolinic acid, matrix substance for MALDI-MS coordinates with metal ions such as copper to form complexes with cytotoxic and antimycobacterial activity. 3-Hydroxypicolinic acid, matrix substance for MALDI-MS is used for the analysis of oligodeoxynucleotides in matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). 3-Hydroxypicolinic acid, matrix substance for MALDI-MS is useful for nucleic acid analysis and anti-tuberculosis compound development .

HY-156087G

Cholicamideβ (GMP)	Biochemical Assay Reagents
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .

Cat. No.	Product Name	Target	Research Area

HY-162396

P-gp inhibitor 21	P-glycoprotein	Cancer
P-gp inhibitor 21 (Compound 56) is an inhibitor for P-glycoprotein (P-gp) transport, which reverses P-gp-mediated multidrug resistance (MDR) and exhibits antitumor efficacy in mice without significant cytotoxicity .

HY-169684

Vaccarin C	Fungal	Infection Cancer
Vaccarin C (Compound VIII) is a cycloheptapeptide with good antifungal activity against pathogenic fungi and dermatophytes M. audouinii and T. mentagrophytes with MIC values of 6 µg/mL. Vaccarin C also has high cytotoxicity against Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines with IC₅₀ values of 3.35 and 5.72 μM, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10796

Miltipolone	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Chenopodiaceae	Others
Miltipolone is a potent cytotoxic compound isolated from the fresh roots of Salvia divinorum .

HY-N9003

Dihydroprehelminthosporol	Structural Classification Natural Products Microorganisms Source classification	Others
Dihydroprehelminthosporol (Compound 1) from the fungusVeronaea sp.of the separated. Dihydroprehelminthosporol on human cancer cell line A549 and SK-0A-3 has cytotoxicity .

HY-N12989

3′-O-Demethylarctigenin	Structural Classification Source classification Phenols Polyphenols Plants Compositae Caesalpinia magnifoliolata Metc.	Others
3′-O-Demethylarctigenin is a phenolic compound that can be isolated from the seeds of Arctium lappa. 3′-O-Demethylarctigenin shows cytotoxicity for PANC-1 cells with an IC₅₀ value of 4.38 µM .

HY-N10542

Aplyronine C	Alkaloids Structural Classification Natural Products Classification of Application Fields Animals Disease Research Fields Cancer	Others
Aplyronine C is an active compound. Aplyronine C shows potent antitumor activity and has cytotoxicity against HeLa-S3 cells with an IC₅₀ values of 22 nM. Aplyronine C can be used for the research of cancer .

HY-N10541

Aplyronine B	Alkaloids Structural Classification Natural Products Classification of Application Fields Animals Disease Research Fields Cancer	Others
Aplyronine B is an active compound. Aplyronine B shows potent antitumor activity and has cytotoxicity against HeLa-S3 cells with an IC₅₀ values of 2.9 nM. Aplyronine B can be used for the research of cancer .

HY-N10538

Shishijimicin B	Alkaloids Structural Classification Natural Products Classification of Application Fields Animals Pyridine Alkaloids Disease Research Fields Indole Alkaloids Cancer	Others
Shishijimicin B is an *active compound* of the enediyne class*. Shishijimicin B shows extremely potent cytotoxicity* with IC₅₀ values of 2.0-3.3 nM. Shishijimicin B has antitumor activity and can be used for the research of cancer . Shishijimicin B is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N6582

Flavokawin C	Structural Classification Chalcones Flavonoids Humulus lupulus L. Source classification Plants Moraceae	Others
Flavokawin C is a natural compound with antioxidative and cytotoxicity .

HY-N12122

Dehydropipernonaline	Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants Piper retrofractum Vahl	Fungal
Dehydropipernonaline (Compound 24) is an amide compound. Dehydropipernonaline shows considerable cytotoxicity to L5178Y mouse lymphoma cells (IC₅₀8.9μM). Dehydropipernonaline can be used for screening antifungal and cytotoxicity .

HY-N3969

Goniotriol (+)-Goniotriol	Structural Classification Natural Products Other Alkaloids Goniothalamus amuyon (Bl.) Merr. Source classification Plants Annonaceae	Others
Goniotriol(compound 2) is a styrylpyronethat can be found in Goniothalamus amuyon. Goniotriolshows cytotoxicity .

HY-N8988

3-Methoxymollugin	Structural Classification Monophenols Source classification Rubiaceae Phenols Plants Rubia cordifolia L.	Others
3-methoxymollugin is a compound that can be isolated from Rubia cordifolia and is cytotoxic ..

HY-N8915

Deoxyflindissone	Triterpenes Structural Classification Cornaceae Terpenoids Source classification Cornus walteri Wangerin Plants	Others
Deoxyflindissone (Compound 13) is a triterpenoid compound. Deoxyflindissone is isolated from natural Cornus walteri .Deoxyflindissone has significant cytotoxic activity .

HY-N1148

Tinospinoside C 8-Hydroxytinophylloloside; 8-epi-Tinospinoside B	Structural Classification Terpenoids Source classification Diterpenoids Tinospora sagittata var. yunnanensis (S.Y.Hu)Lo Plants Menispermaceae	Others
Tinospinoside C (compound 5) is a diterpene. Tinospinoside C has *cytotoxic* and antifouling activities .

HY-N12730

Euphoscopin B	Structural Classification Terpenoids Source classification Euphorbia helioscopia L. Diterpenoids Euphorbiaceae Plants	Others
Euphoscopin B (compound 5) is a cytotoxic macrocyclic diterpene isolated from Euphorbia helioscopia L .

HY-123724

Ravidomycin	Structural Classification Monophenols Microorganisms Source classification Phenols	Others
Ravidomycin is a compound with antibacterial and cytotoxic activities. New analogs have been isolated from microorganisms. These analogs differ in antibacterial selectivity compared with known compounds.

HY-N3630

Coronarin D	Hedychium coronarium Koen. Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Plants Disease Research Fields Zingiberaceae	Others
Coronarin D is a cytotoxic labdan-type diterpenes compound isolated from the rhizomes of H. coronarium .

HY-128498

Anticancer agent 182	Structural Classification Monophenols Source classification Phenols Muntingia calabura L. Plants Muntingiaceae	Others
Anticancer agent 182 (Compound 1) is a cytotoxic flavonoid compound isolated from the root ofMuntingia colabura L. Anticancer agent 182 exhibits anticancer activity .

HY-N7256

Dihydrocephalomannine	Other Terpenoids Structural Classification Classification of Application Fields Terpenoids Source classification Plants Cephalotaxaceae Disease Research Fields Cancer Cephalotaxus fortunei Hooker	Microtubule/Tubulin
Dihydrocephalomannine (compound 1b), an analogue of Paclitaxel, shows reduced cytotoxicity and tubulin binding compared to Paclitaxel .

HY-N3800

Eichlerialactone	Structural Classification Terpenoids Chisocheton penduliflorus Planch. ex Hiern Sesquiterpenes Source classification Plants Meliaceae	Others
Eichlerialactone is a sesquiterpene compound isolated from Chisocheton penduliflorus. Eichlerialactone is weakly cytotoxic to breast cancer cells .

HY-N11572

Anticancer agent 96	Structural Classification Terpenoids Pterocarpus macrocarpus Kurz Sesquiterpenes Source classification Plants Compositae	Others
Anticancer agent 96 (Compound 4) is an anticancer agent that shows cytotoxic activities against human cancer cells .

HY-N9186

Bakkenolide Db	Structural Classification Natural Products Petasites formosanus Kitam. Source classification Plants Compositae	Others
Bakkenolide Db is a compound that can be isolated from the root of Petasites formosanus. Bakkenolide Db may have cytotoxicity .

HY-N15414

Demethoxykanugin Desmethoxykanugin	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Derris indica	Cholinesterase (ChE)
Demethoxykanugin (Desmethoxykanugin, compound 1) is a acetylcholine (AChE) inhibitor. Demethoxykanugin shows cell cytotoxicity agains Vero cells .

HY-N12192

Ebenifoline E-II	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Celastraceae Euonymus laxiflorus Champ. ex Benth. Plants	Others
Ebenifoline E-II (Compound 2) is a sesquiterpene alkaloid derived from Euonymus laxiflorus. Ebenifoline E-II is cytotoxic .

HY-N3448

Isowigtheone	Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	Others
Isowigtheone is a cytotoxic isoflavone compound isolated from the root barks of Brosimum utile. Isowigtheone has the potential for the research of cancer diseases .

HY-N4189

Isocucurbitacin B	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
Isocucurbitacin B is a potent cytotoxic compound isolated from Helicteres rswa L. (Sterculiaceae). Isocucurbitacin B possesses anti-tumor acticity .

HY-N1081A

Viteralone (S)-Viteralone	Terpenoids Verbenaceae Sesquiterpenes Plants Vitex negundo Linn.	Others
Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

HY-N12524

Cyclo(prolyltyrosyl)	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Endogenous metabolite	Bacterial
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .

HY-N5007

Galgravin	Structural Classification Classification of Application Fields Magnoliaceae Source classification Lignans Magnolia Liliflora Desr. Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis
Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells .

HY-N11015

Withaphysalin R	Structural Classification Physalis minima Linn. Source classification Plants Solanaceae Steroids	Others
Withaphysalin R (compound 5) is a Withanolide that can be isolated from the Solanaceae. Withanolide is a steroid ester with an ergosterol skeleton, and some of these compounds have some significant activities, including cytotoxic and immunosuppressive, antitumor, anti-inflammatory, anticonvulsive, and antioxidant .

HY-N6060

Ophiopogonanone B	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Flavonoids Liliaceae Source classification Plants Isoflavones	Others
Ophiopogonanone B is a homoisoflavone (compound 8) with an IC₅₀ value of 15.42 μM for cytotoxicity against human lung cancer A5A9 cell line .

HY-120529

Aciculatin	Structural Classification Flavonoids Flavones Gramineae Source classification Plants Themeda arguens (L.) Hack.	Biochemical Assay Reagents
Aciculatin is a compound with cytotoxic, anti-inflammatory and anti-arthritic activities, and its synthetic route including specific chemical reaction steps was determined through the first total synthesis.

HY-N7173

7-Methoxy-β-carboline-1-propionic acid	Alkaloids Structural Classification other families Ketones, Aldehydes, Acids Eurycoma longifolia Jack Plants	Parasite
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

HY-N13118

Sinopodophylline B	Structural Classification Flavonoids Flavones Sinopodophyllum hexandrum (Royle) Ying Source classification Plants Berberidaceae	Others
Sinopodophylline B (compound 2) is a flavonoid glycoside compound that is cytotoxic to breast cancer cells. For example, the IC₅₀ of Sinopodophylline B is 1.5 μM (T47D) and 44.2 μM (MDA-MB-231), respectively .

HY-N15407

Asparagoside A	Structural Classification Liliaceae Source classification Plants Saccharides Monosaccharides Asparagus officinalis L.	Others
Asparagoside A is a steroidal compound that can be isolated and extracted from the roots of Asparagus officinalis. Asparagoside A has certain cytotoxicity against tumor cells and can be used in the study of cancer .

HY-122944

20-Deoxocarnosol	Structural Classification Terpenoids Labiatae Diterpenoids Salvia deserta Schang Plants	Others
20-Deoxocarnosol (compound 7) is a potent anti-cancer agent that can be found in the roots of Salvia deserta. 20-Deoxocarnosol shows cytotoxicity in cancer cells .

HY-N12584

Pulchinenoside E4	Structural Classification Polysaccharides Source classification Ranunculaceae Plants Saccharides Pulsatilla chinensis (Bunge) Regel	Others
Pulchinenoside E4 (compound 2) is an oleanane-type triterpenoidal saponin that can be found in the roots ofPulsatilla chinensis . Pulchinenoside E4 shows cytotoxic activity .

HY-N7803

De-O-Methyllasiodiplodin	Structural Classification Ludwigia hyssopifolia (G. Don) exell. Source classification Phenols Polyphenols Plants Onagraceae Juss.	Apoptosis
De-O-Methyllasiodiplodin, a cytotoxic compound, can be isolated from Ludwigia hyssopifolia. De-O-Methyllasiodiplodin inhibits Hep-2 cell growth by inducing apoptosis .

HY-W024604

4,4-Dimethyl-2-cyclopenten-1-one 4,4-Dimethylcyclopent-2-enone	Apocynaceae Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Apocyniveneti Folium Disease Research Fields Cancer	Others
4,4-Dimethyl-2-cyclopenten-1-one, a natural compound from Apocyniveneti Folium, displays higher tumor-specific cytotoxicity .

HY-N3687

Dasycarpol	Structural Classification Natural Products Microorganisms Source classification	Others
Dasycarpol (compound 2) is a product of microbial transformation of fraxinellone by Aspergillus niger (AS 3.421). Dasycarpol shows moderate cytotoxicity against A549 cells ,with the IC₅₀ of 20 ug/mL .

HY-N10071

Poricoic acid G	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

HY-N10229

Harzianum A	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Fungal
Harzianum A is a trichothecene compound. Harzianum A has no antibacterial activity against Gram-negative and Gram-positive bacteria, but has antifungal activity. In addition, Harzianum A is cytotoxic to tumor cells .

HY-N3191

N-trans-Feruloyl-3-methyldopamine	Structural Classification Source classification Phenols Polyphenols Amaranthaceae Plants Alternanthera philoxeroides (Mart.) Griseb.	Others
N-trans-Feruloyl-3-methyldopamine (compound 4) is an anticancer compound isolated from Alternanthera philoxeroides. N-trans-Feruloyl-3-methyldopamine is cytotoxic to HeLa cells, with an inhibition rate of 72.2% at a concentration of 30 μg/mL .

HY-138210

N,O-Diacetyltyramine	Structural Classification Natural Products Microorganisms Source classification	Fungal
N,O-Diacetyltyramine is a compound with antibacterial activity and cytotoxicity that can be isolated from the actinomycete Pseudonocardia endophytica VUK-10. N,O-Diacetyltyramine has antibacterial activity against Gram-positive and Gram-negative bacteria and fungi. N,O-Diacetyltyramine is cytotoxic to MDA-MB-231, HeLa, MCF-7 and OAW-42 cells .

HY-129144

Dihydrodehydrodiconiferyl alcohol	Structural Classification Anogeissus acuminata (Roxb. ex DC.) Guill. Monophenols Combretaceae Source classification Phenols Plants	TNF Receptor
Dihydrodehydrodiconiferyl alcohol (compound 2) is a kind of neolignan. Dihydrodehydrodiconiferyl alcohol can be isolated from Anogeissus acuminata. Dihydrodehydrodiconiferyl alcohol has specific cytotoxic activity on melanoma cancer cell line .

HY-N1116

Tsugafolin	Structural Classification Flavonoids Pseudognaphalium affine (D. Don) Anderberg Labiatae Flavonones Source classification Plants	HIV
Tsugafolin (compound 4) is a dehydroflavone with weak anti-HIV activity (IC₅₀=118 μM) and devoid cytotoxicity (<150 μM). Tsugafolin can be isolated from Vitex leptobotrys .

HY-N10417

Apoptosis inducer 5	Monophenols Classification of Application Fields Source classification Lignans Rosaceae Phenols Phenylpropanoids Crataegus pinnatifida Bge. Plants Disease Research Fields Cancer	Apoptosis Autophagy
Apoptosis inducer 5 (compound 1b) is a lignan enantiomer that can be found in Crataegus pinnatifida. Apoptosis inducer 5 exhibits cytotoxic effect via apoptosis and autophagy in Hep3B cells .

HY-126981

Sarasinoside B1	Structural Classification Polysaccharides Marine natural products Source classification Sponge Saccharides	Others
Sarasinoside B1 is a glycoside compound. Sarasinoside B1 exhibits moderate cytotoxicity against Neuro-2a and HepG2 cell lines (IC50=~5-18 μM).

HY-N9159

Piptocarphin F	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Dalbergia frutescens (Vell.) Britton	Others
Piptocarphin F (Compound 5) is a sesquiterpene lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell line HL-60 (IC₅₀=5.69 μmol*L ^-1) .

HY-N7287

(+)-Matairesinol	Structural Classification Thymelaeaceae Source classification Lignans Phenylpropanoids Plants Wikstroemia indica	Others
(+)-Matairesinol is a lignan. (+)-Matairesinol has no cytotoxic activity for human pancreatic PANC-1 cancer cells .

HY-N8098

Pulchinenoside E2	Triterpenes Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Source classification Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Cancer	Others
Pulchinenoside E2 (Compound 8) is a triterpene saponin isolated from the roots of Pulsatilla chinensis. Pulchinenoside E2 shows cytotoxic to HL-60 cells with an IC₅₀ value of 2.6 µg/mL .

HY-122496

Malvidin chloride Syringidin	Structural Classification Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Anthocyans Flavonoids Microorganisms other families Phenols Polyphenols Disease Research Fields Cancer	Apoptosis
Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G₂/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer .

Cat. No.	Product Name	Chemical Structure

HY-N1318S

Salvigenin-d9
Salvigenin-d₉ is the deuterium labeled Salvigenin. Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties .

Cat. No.	Product Name		Classification

HY-163143

HDAC8-IN-6		Alkynes
HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC₅₀ of 5.1 μM. HDAC8-IN-6 shows cytotoxicity .

HY-159511

Hedgehog IN-7		Azide
Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of Hedgehog, capable of reducing the expression of Hedgehog genes and inhibiting Hedgehog signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards the Hedgehog pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer .

HY-159119

hDHODH-IN-15		Alkynes
hDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC₅₀ of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC₅₀ of 0.95-2.81 µM. hDHODH-IN-15 induces ferroptosis in HCT-116, and exhibits antitumor efficacy .

HY-159921

Tubulin Polymerization-IN-1 prodrug		Alkynes
Tubulin Polymerization-IN-1 prodrug (Compound 2b) is a palladium (Pd)-mediated tubulin polymerization inhibitor prodrug. Developed based on colchicine binding site inhibitors (CBSIs), it reduces toxicity and enhances targeted release properties. Compared to the parent compound, Tubulin Polymerization-IN-1 prodrug exhibited 68.3-fold lower cytotoxicity, which can be restored in situ in the presence of Pd resin. Mechanistic studies showed that its anticancer activity is consistent with CBSIs. In vivo, Tubulin Polymerization-IN-1 prodrug significantly inhibited tumor growth (63.2%) when activated by Pd resin. It holds promise for research in the field of anticancer therapy .

HY-149058

Neuraminidase-IN-13		Azide
Neuraminidase-IN-13 (Compound 10) is a neuraminidase inhibitor with antiviral activity and low cytotoxicity. Neuraminidase-IN-13 significantly inhibits NDV infection of Vero cells by preventing the release of viral particles from infected cells . Neuraminidase-IN-13 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159495

Keap1-Nrf2-IN-21		Azide
Keap1-Nrf2-IN-21 (compound 4d) is a glucose metabolism inhibitor with antitumor activity. Keap1-Nrf2-IN-21 inhibits glycolytic activity of cancer cells by targeting the glycolytic pathway, especially by affecting the Keap1-Nrf2 signaling pathway, thereby inhibiting tumor growth. Keap1-Nrf2-IN-21 exhibits cytotoxicity against the HEC1A cell line (IC₅₀=2.60 μM) .

HY-151738

Fmoc-Aeg(N3)-OH		Azide
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-156087

Cholicamideβ		Adjuvant
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .

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