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Results for "

St

" in MedChemExpress (MCE) Product Catalog:

178

Inhibitors & Agonists

22

Biochemical Assay Reagents

9

Peptides

9

Inhibitory Antibodies

3

Natural
Products

60

Recombinant Proteins

3

Isotope-Labeled Compounds

16

Antibodies

65

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136782

    Flavivirus Dengue Virus Infection
    ST-148 maleate is a potent and orally active DENV inhibitor. ST-148 maleate shows antiviral efficacy and low cell toxicity. ST-148 alters the interaction between lipid droplets and the C protein, thereby inhibiting viral replication. .
    ST-148 maleate
  • HY-105003

    Adenosine Receptor Neurological Disease
    ST 1535 is a potent and orally active A2A adenosine receptor antagonist. ST 1535 shows antiparkinsonian activity and antitremorigenic effects. ST 1535 has the potential for the research of Parkinson’s disease .
    ST 1535
  • HY-120541

    Histamine Receptor Inflammation/Immunology
    ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect .
    ST-1006
  • HY-163737

    Microtubule/Tubulin Cancer
    ST-401, a microtubule-targeting agent (MTA), is a brain-penetrant microtubule (MT) assembly inhibitor. ST-401 disrupts microtubule (MT) function through gentle and reverisible reduction in MT assembly that triggers mitotic delay and cell death in interphase. ST-401 shows a potent antitumor activity .
    ST-401
  • HY-114383

    Deubiquitinase Autophagy Neurological Disease
    ST-539 is the inhibitor for deubiquitinase USP30 with IC50 of 0.37 μM. ST-539 promotes the ubiquitination of mitochondrial proteins, and induces mitochondrial autophagy, thereby regulating mitochondrial homeostasis. ST-539 can be used in research of neurodegenerative diseases .
    ST-539
  • HY-176466

    Platelet-activating Factor Receptor (PAFR) TNF Receptor Inflammation/Immunology
    ST-899 is a novel platelet-activating factor (PAF) receptor antagonist. ST-899 can significantly reduce the mortality of mice with endotoxin (LPS)-induced shock. ST-899 can significantly inhibit the increase in serum tumor necrosis factor (TNF) levels induced by LPS, but has no effect on interleukin-6 (IL-6). The regulatory mechanism of ST-899 is to block the positive feedback loop between PAF and TNF, thereby reducing the inflammatory response. ST-899 can be used to study inflammatory diseases such as septic shock .
    ST-899
  • HY-120541A

    Histamine Receptor Inflammation/Immunology
    ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect .
    ST-1006 Maleate
  • HY-111280

    Dopamine Receptor Neurological Disease
    ST 198 is an orally active D3R antagonist. ST 198 can block the expression of nicotine-induced CPP at doses selective for D3R. ST 198 can be used for the research of neurological disease .
    ST 198
  • HY-162609

    Sodium Channel Cardiovascular Disease Neurological Disease
    ST-2560 is a selective inhibitor of the NaV1.7 sodium channel with IC50 value of 39 nM. ST-2560 can be used to study pain behavior and cardiovascular models .
    ST-2560
  • HY-15238A

    Dopamine Receptor Neurological Disease
    ST-836 hydrochloride (compound 34) is a potent dopamine receptor ligand with Ki values of 4.5 nM, 132 nM for D3 and D2, respectively. ST-836 hydrochloride has the potential for Parkinson’s disease .
    ST-836 hydrochloride
  • HY-P991618

    Transmembrane Glycoprotein Cancer
    ST2485 is a monoclonal antitenascin antibody. ST2485 shows additivity in tenascin C binding in vitro as well as in a xenograft model. ST2485 binds human tenascin at an epitope partially shared with BC2. ST2485 cross-reacts with murine tenascin. ST2485 can be studied in antitumor research .
    ST2485
  • HY-15238

    Dopamine Receptor Neurological Disease
    ST-836 is a dopamine receptor ligand; Antiparkinsonian agent.
    ST-836
  • HY-121663

    Dengue Virus Infection
    ST-148 is a novel small molecule compound that has potent inhibitory effects against all four dengue virus serotypes. In the nonlethal AG129 mouse dengue virus infection model, ST-148 significantly reduced viremia and viral load in vital organs and tended to reduce plasma cytokine levels. Compound resistance was associated with the dengue virus capsid (C) gene, and the direct interaction of ST-148 with the C protein was presumed to be achieved through the protein's built-in fluorescence change in the presence of the compound. Therefore, ST-148 appears to interact with the dengue virus C protein and inhibit one or more unique steps of the viral replication cycle.
    ST-148
  • HY-116247

    PPAR Metabolic Disease Inflammation/Immunology
    ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ .
    ST247
  • HY-168532

    Interleukin Related Inflammation/Immunology
    ST2-IN-1 (compound 31) is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 7 μM in AlphaLISA assay, and 7.19 μM in HEK-Blue assay. ST2-IN-1 effectively attenuats the ST2/IL-33 signaling in human mast cells .
    ST2-IN-1
  • HY-169084

    Glycosyltransferase Cancer
    ST-IN-1 (compound (R)-1) is a selective ST inhibitor (Ki=70 nM, rat a-2,6-ST; Ki=19 nM, hST6GAL1) with antitumor activity. ST-IN-1 inhibits tumor growth and metastasis by delipidating the surface of tumor cells .
    ST-IN-1
  • HY-116543

    Apoptosis Cancer
    ST362 is a anti-cancer agent. ST362 induces cell apoptosis and inhibits cancer cell growth .
    ST362
  • HY-50937
    ST 2825
    Maximum Cited Publications
    68 Publications Verification

    MyD88 Inflammation/Immunology
    ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 interferes with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1β-mediated activation of NF-κB transcriptional activity .
    ST 2825
  • HY-112840

    Adenosine Receptor Neurological Disease
    ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A2A receptor, with Kis of 8 nM and 33 nM for A2A and A1 receptors, respectively.
    ST3932
  • HY-133490A

    Apoptosis Cancer
    ST1074 is a dual CerS2/CerS4 inhibitor that induces apoptosis. ST1074 can be used in cancer research .
    ST1074
  • HY-E70287

    St6GALNAC5

    Glycosyltransferase Metabolic Disease
    ST6 Sialyltransferase 5 (EC:2.4.3.3, ST6GALNAC5, SIAT7E, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5) transfers a sialic acid to N-acetylgalactosamine (GalNAc) residues. ST6 Sialyltransferase 5 is a bio-marker in cervical screening samples .
    ST6 Sialyltransferase 5
  • HY-N13228

    Others Others
    St John's Wort Extract is the extract of St John's Wort, with content of 0.3% Hypercins.
    St John's Wort Extract
  • HY-117918

    FXR Metabolic Disease Inflammation/Immunology
    ST-1892 (compound 14) is a highly potent FXR agonist (EC50=7.2 nM) that can be used to study diseases or disorders caused by metabolic inflammation .
    ST-1892
  • HY-112446

    Others Inflammation/Immunology
    ST638 is a potent tyrosine kinase inhibitor (IC50=370 nM). ST638 also targets the CSF-1 receptor and inhibits PGE2 production .
    ST638
  • HY-173496

    Sialyltransferase Integrin VEGFR Akt Cancer
    ST6GAL1-IN-1 is an orally active selective ST6GAL1 inhibitor (IC50 = 20 μM). ST6GAL1-IN-1 exhibits high antimetastatic potential, effectively inhibiting the migration of MDA-MB-231 cells at noncytotoxic concentrations. ST6GAL1-IN-1 can disrupt integrin sialylation in MDA-MB-231 cells. ST6GAL1-IN-1 inhibits tumor angiogenesis and cancer metastasis via the Integrin/VEGFR2-mediated signaling pathway. ST6GAL1-IN-1 effectively suppresses both tumor growth and cancer metastasis on the MDA-MB-231 xenograft model. ST6GAL1-IN-1 can be used for the study of Triple-negative breast cancer (TNBC) .
    ST6GAL1-IN-1
  • HY-101441
    ST-193
    4 Publications Verification

    Arenavirus Infection
    ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
    ST-193
  • HY-101441A
    ST-193 hydrochloride
    4 Publications Verification

    Arenavirus Infection
    ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
    ST-193 hydrochloride
  • HY-P2624

    PAK Metabolic Disease
    st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage .
    st-Ht31
  • HY-E70288

    St6GALNAC6

    Others Inflammation/Immunology
    ST6 Sialyltransferase 6 (ST6GALNAC6) belongs to the salivary transferase family, which modifies proteins and ceramides on the cell surface, thereby altering intercellular or extracellular matrix interactions. ST6 Sialyltransferase 6 can be used in the study of inflammatory bowel disease (IBD) .
    ST6 Sialyltransferase 6
  • HY-117423

    PARP Cancer
    ST7710AA1 (compound 1l) is a potent PARP-1 inhibitor with an IC50 value of 0.07 µM. ST7710AA1 shows an antiproliferative activity. ST7710AA1 shows anticancer activity .
    ST7710AA1
  • HY-106688

    St-567

    Potassium Channel Cardiovascular Disease
    Alinidine (St-567) is a specific bradycardic agent. Alinidine reduces the slope of the diastolic depolarization in sinoatrial tissue and Purkinje fibers. Alinidine shows antiischemic and antiarrhythmic effects .
    Alinidine
  • HY-U00341

    Adenosine Receptor Neurological Disease
    ST4206 is a potent and orally active adenosine A2A receptor antagonist, with Kis of 12 nM and 197 nM for adenosine A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson׳s disease research .
    ST4206
  • HY-175231

    5-HT Receptor Neurological Disease
    ST171 is a bitopic 5-HT1AR agonist with an Ki of 0.41  nM. ST171 selectively activates Gi/o signaling pathway and inhibits 5-HT1AR-mediated cAMP accumulation without Gs activation and marginal β-arrestin recruitment. T171 reduces hypersensitivity in chronic neuropathic and inflammatory pain mice model. ST171 can be used for pain research .
    ST171
  • HY-P2624A

    PAK Metabolic Disease
    st-Ht31 ammonium is a membrane-permeable peptide inhibitor of?protein kinase A (PKA) anchoring. st-Ht31 ammonium induces robust cholesterol/phospholipid efflux. st-Ht31 ammonium completely reverses foam cell formation and restores the metabolic health of macrophage .
    st-Ht31 ammonium
  • HY-162503

    Bacterial Infection
    ST166 free acid is a inhibitor of formation of the PhoP-DNA complex with the IC50 values of 18 and 24 μM against PhoP and MtrAC binding with DNA, respectively. ST166 free acid shows antibacterial activity against Macrobacterium marinum .
    ST166 free acid
  • HY-103203

    Adrenergic Receptor Neurological Disease
    ST91 is a α2-adrenoceptor (α2AR) agonist. ST91 activates both α2AAR and non-α2AAR subtypes to produce spinal antinociception .
    ST91
  • HY-13071
    Nestoron
    1 Publications Verification

    St-1435; Elcometrine

    Progesterone Receptor Endocrinology
    Nestoron (ST-1435) is a 19-norprogesterone derivative with high affinity and selectivity for progesterone receptors. Nestoron is a highly selective and potent progestogen that can be used as a hormonal contraceptive .
    Nestoron
  • HY-161774

    CD73 Cancer
    ST80 is an inhibitor for interaction of OTUD4 and CD73. ST80 decreases CD73 protein level, increases CD73 protein turnover, reduces immune evasion of tumor cells, and thus exhibits antitumor efficacy against immunosuppressive triple-negative breast cancer (TNBC) .
    ST80
  • HY-B0932

    L-Propionylcarnitine chloride; St-261

    Others Others
    Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.
    Levocarnitine propionate hydrochloride
  • HY-101279
    ST034307
    3 Publications Verification

    Adenylate Cyclase Neurological Disease
    ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.
    ST034307
  • HY-106688A

    St-567 hydrobromide

    Potassium Channel Cardiovascular Disease
    Alinidine (St-567) hydrobromide is a specific bradycardic agent. Alinidine hydrobromide reduces the slope of the diastolic depolarization in sinoatrial tissue and Purkinje fibers. Alinidine hydrobromide shows antiischemic and antiarrhythmic effects .
    Alinidine hydrobromide
  • HY-P10873

    Nuclear Hormone Receptor 4A/NR4A Mitochondrial Metabolism Cancer
    ST-CY14 is an inhibitor for Nur77-PPARγ interaction with an EC50 of 3.15 μM, that binds to Nur77 (Kd=32 nM), blocks Nur77 from being ubiquitinated and degraded by PPARγ, reduces fatty acid uptake and mitochondrial respiration, and inhibits the transcription of CD36 and FABP4. ST-CY14 inhibits the proliferation and migration of cancer cell MCF7 and MDA-MB-231. ST-CY14 inhibits tumor growth and bone metastasis in mouse models .
    ST-CY14
  • HY-103110
    ST1936
    1 Publications Verification

    5-HT Receptor Adrenergic Receptor Neurological Disease
    ST1936 is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor .
    ST1936
  • HY-B0063

    St1481

    Topoisomerase Cancer
    Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity .
    Gimatecan
  • HY-114794

    St 1059

    Adrenergic Receptor Drug Metabolite Cardiovascular Disease
    Desglymidodrine (ST 1059), the active metabolite of Midodrine(HY-12749), is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure .
    Desglymidodrine
  • HY-E70301

    St8SIA4

    Endogenous Metabolite Cancer
    ST8 alpha-2,8-Sialyltransferase 4 (ST8SIA4) is a sialyltransferase that participates in the sialylation mechanism. ST8 alpha-2,8-Sialyltransferase 4 has also been implicated in breast cancer development and mediates cell proliferation and invasion of cancer cells in a sialyltransferase-dependent manner .
    ST8 alpha-2,8-Sialyltransferase 4
  • HY-RS13845

    Small Interfering RNA (siRNA) Others

    ST18 Human Pre-designed siRNA Set A contains three designed siRNAs for ST18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ST18 Human Pre-designed siRNA Set A
    ST18 Human Pre-designed siRNA Set A
  • HY-RS13854

    Small Interfering RNA (siRNA) Others

    ST7 Human Pre-designed siRNA Set A contains three designed siRNAs for ST7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ST7 Human Pre-designed siRNA Set A
    ST7 Human Pre-designed siRNA Set A
  • HY-RS19643

    Small Interfering RNA (siRNA) Others

    St18 Mouse Pre-designed siRNA Set A contains three designed siRNAs for St18 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    St18 Mouse Pre-designed siRNA Set A
    St18 Mouse Pre-designed siRNA Set A
  • HY-RS17648

    Small Interfering RNA (siRNA) Others

    St13 Mouse Pre-designed siRNA Set A contains three designed siRNAs for St13 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    St13 Mouse Pre-designed siRNA Set A
    St13 Mouse Pre-designed siRNA Set A

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