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NAD(P)H

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113324
    NADPH
    10+ Cited Publications

    Endogenous Metabolite Cancer
    NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms .
    NADPH
  • HY-P2996

    Others Others
    NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants, the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .
    NAD(P)H-Nitrate reductase
  • HY-F0003R

    Reference Standards Ferroptosis Endogenous Metabolite Metabolic Disease Cancer
    NADPH tetrasodium salt (Standard) is the analytical standard of NADPH tetrasodium salt (HY-F0003). This product is intended for research and analytical applications. NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication.
    NADPH tetrasodium salt (Standard)
  • HY-F0003A
    NADPH tetracyclohexanamine
    10+ Cited Publications

    Ferroptosis Endogenous Metabolite Metabolic Disease Cancer
    NADPH tetracyclohexanamine functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetracyclohexanamine is an endogenous inhibitor of ferroptosis. NADPH tetracyclohexanamine plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication .
    NADPH tetracyclohexanamine
  • HY-F0003
    NADPH tetrasodium salt
    10+ Cited Publications

    Ferroptosis Endogenous Metabolite Metabolic Disease Cancer
    NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication .
    NADPH tetrasodium salt
  • HY-152026

    NADPH Oxidase Neurological Disease
    NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC50s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .
    NADPH oxidase-IN-1
  • HY-163002

    Ferroptosis Cancer
    viFSP1 is a species-independent FSP1 inhibitor. viFSP1 directly inhibits FSP1 by targeting the highly conserved NAD(P)H binding pocket of FSP1. viFSP1 can induce Ferroptosis in FSP1-dependent cells. viFSP1 can be used in renal and breast cancer research .
    viFSP1
  • HY-F0003AR

    Ferroptosis Endogenous Metabolite Others
    NADPH (tetracyclohexanamine) (Standard) is the analytical standard of NADPH (tetracyclohexanamine). This product is intended for research and analytical applications. 0
    NADPH tetracyclohexanamine (Standard)
  • HY-P2996B

    Others Others
    Nitrate Reductase (NAD[P]H), Pichia pastoris (recombinant) is a simplified version of nitrate reductase S-NaR1 expressed and purified by Pichia pastoris. Nitrate Reductase (NAD[P]H), Pichia Pastoris (recombinant) contains sites binding molybdenum-molybdenopyridine (Mo-MPT) and nitrate reduction active sites and only contains two domains instead of the five domains of the complete NaR. This simplified form of nitrate reductase was expressed in high density in P. pastoris and purified to homogeneity in one step by fixed metal affinity chromatography (IMAC). Nitrate Reductase (NAD[P]H), Pichia Pastoris (recombinant) can be used in the development of biosensors and environmental monitoring .
    Nitrate Reductase (NAD[P]H), Pichia Pastoris (recombinant)
  • HY-P2996A

    Drug Isomer Others
    Nitrate Reductase, Arabidopsis thaliana is the isomer of NAD(P)H-Nitrate reductase (HY-P2996). NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants,the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .
    Nitrate Reductase, Arabidopsis thaliana
  • HY-169842

    Quinone Reductase Cancer
    NSC 645827 is an inhibitor for NAD(P)H: quinone oxidoreductase 1 (NQO1) with an IC50 of 0.7 μM .
    NSC 645827
  • HY-E70002

    Biochemical Assay Reagents Others
    Deamino-NADPH is a 2'-phosphorylated coenzyme. Deamino-NADPH can be used in ammonia determination .
    Deamino-NADPH
  • HY-172227

    Mitochondrial Metabolism Cardiovascular Disease
    S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). S-15176 inhibits mitochondrial swelling induced by tert-butylhydroperoxide with an IC50 value of 45.7 μM. S-15176 inhibits PTP opening, prevents mitochondrial membrane potential dissipation and NAD(P)H oxidation, and increases mitochondrial calcium loading capacity. S-15176 is promising for research of ischemia-reperfusion injury .
    S-15176
  • HY-125027

    IB-DNQ

    Quinone Reductase Cancer
    Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer .
    Isobutyl-deoxynyboquinone
  • HY-D0937
    Methoxy-PMS
    3 Publications Verification

    1-Methoxy PMS; 1-Methoxyphenazine methosulfate

    Reactive Oxygen Species (ROS) Others
    Methoxy-PMS (1-Methoxy PMS), an active oxygen formation inducer, is stable electron-transport mediator between NAD(P)H and tetrazolium dyes .
    Methoxy-PMS
  • HY-W002555

    Drug Intermediate Others
    4-Aminonicotinic acid is a building block, that can be used for synthesis of pharmaceutical agents. 4-Aminonicotinic acid can be used as the substrate or inhibitor in the research of NAD(P)H metabolism and the activity of related enzymes .
    4-Aminonicotinic acid
  • HY-E70014

    FAD-GDH; Glucose 1-dehydrogenase

    Endogenous Metabolite Others
    FAD-dependent glucose dehydrogenase (EC 1.1.5.9), or glucose dehydrogenase (FAD)/Pseudomonas glucose dehydrogenase. Glucose 1-dehydrogenase is an enzyme used as a regeneration cofactor to convert glucose and NAD(P) into NAD(P)H and gluconic acid .
    FAD-dependent glucose dehydrogenase
  • HY-P2947

    Aldehyde dehydrogenase (NAD(P))

    Aldehyde Dehydrogenase (ALDH) Others Cancer
    ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress .
    ALDH
  • HY-P2993

    ICDH; IDH

    Isocitrate Dehydrogenase (IDH) Metabolic Disease Cancer
    Isocitrate dehydrogenase, Porcine heart (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P) + to NAD(P)H, it plays important roles in cellular metabolism .
    Isocitrate dehydrogenase, Porcine heart
  • HY-P2993A

    ICDH, Microorganism; IDH, Microorganism

    Isocitrate Dehydrogenase (IDH) Metabolic Disease
    Isocitrate dehydrogenase, Microorganism (IDH) (EC 1.1.1.42) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P) + to NAD(P)H, it plays important roles in cellular metabolism .
    Isocitrate dehydrogenase, Microorganism
  • HY-107855S

    (±)-Mevalonolactone-d7; Mevalolactone-d7

    Endogenous Metabolite Metabolic Disease
    DL-Mevalonolactone-d7 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling .
    DL-Mevalonolactone-d7
  • HY-107855S1

    (±)-Mevalonolactone-d3; Mevalolactone-d3

    Endogenous Metabolite Metabolic Disease
    DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone . DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling .
    DL-Mevalonolactone-d3
  • HY-W478741

    Endogenous Metabolite Keap1-Nrf2 NF-κB Metabolic Disease Cancer
    Pyrraline is an Nrf2 pathway activator with antioxidant and anti-inflammatory effects. Pyrraline upregulates antioxidant enzymes such as NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1) via antioxidant response element (ARE) activation, while inhibiting NFκB-mediated inflammation. Pyrraline is promising for research of metabolic disorders (such as diabetic nephropathy) and cancers .
    Pyrraline
  • HY-176757

    NADPH Oxidase Cancer
    N-Benzyl-N-demethylpronqodine A (Compound 16) is an inhibitor of NAD(P)H:quinine acceptor oxidoreductase 1 (NQO1) with an IC50 of 83.3 nM .
    N-Benzyl-N-demethylpronqodine A
  • HY-N0645
    Dicoumarol
    5+ Cited Publications

    Dicumarol

    Quinone Reductase PDHK Cancer
    Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50s of 0.37 and 19.42 μM, respectively.
    Dicoumarol
  • HY-103667
    2-HBA
    3 Publications Verification

    Quinone Reductase Caspase Cancer
    2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
    2-HBA
  • HY-N7335

    Quinone Reductase Others Neurological Disease Inflammation/Immunology Cancer
    Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities .
    Dehydroglyasperin C
  • HY-N0645S

    Dicumarol-d8

    Isotope-Labeled Compounds PDHK Cancer
    Dicoumarol-d8 (Dicumarol-d8) is the deuterium labeled Dicoumarol. Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50s of 0.37 and 19.42 μM, respectively.
    Dicoumarol-d8
  • HY-15924
    Thiazolyl Blue
    Maximum Cited Publications
    141 Publications Verification

    MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide

    Fluorescent Dye Others
    Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .
    Thiazolyl Blue
  • HY-W975966

    Keap1-Nrf2 Neurological Disease
    CPDT is an orally active and highly potent inducer of phase 2 enzymes and an activator of Nrf2. The activities of key phase 2 enzymes, including glutathione S-transferase, NAD(P)H:quinone:oxidoreductase 1 and glutamate cysteine synthetase, and levels of glutathione were elevated by CPDT in rat bladder in vivo and in cultured bladder cells in vitro [2].
    CPDT
  • HY-13543

    CB 1954

    Quinone Reductase DNA Alkylator/Crosslinker Cancer
    Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .
    Tretazicar
  • HY-128895
    KL1333
    1 Publications Verification

    Quinone Reductase Mitochondrial Metabolism Metabolic Disease
    KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .
    KL1333
  • HY-12804
    VAS2870
    10+ Cited Publications

    NADPH Oxidase Cardiovascular Disease
    VAS2870 is a NADPH oxidase (NOX) inhibitor.
    VAS2870
  • HY-RS18996

    Small Interfering RNA (siRNA) Others

    Decr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Decr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Decr1 Mouse Pre-designed siRNA Set A
    Decr1 Mouse Pre-designed siRNA Set A
  • HY-RS03667

    Small Interfering RNA (siRNA) Others

    DECR1 Human Pre-designed siRNA Set A contains three designed siRNAs for DECR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DECR1 Human Pre-designed siRNA Set A
    DECR1 Human Pre-designed siRNA Set A
  • HY-113325
    NADP
    5+ Cited Publications

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .
    NADP
  • HY-18950
    GSK2795039
    65+ Cited Publications

    NADPH Oxidase Reactive Oxygen Species (ROS) Apoptosis Cancer
    GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption . GSK2795039 reduces apoptosis .
    GSK2795039
  • HY-F0002
    NADP sodium salt
    5+ Cited Publications

    Sodium NADP

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .
    NADP sodium salt
  • HY-113325A
    NADP sodium hydrate
    5+ Cited Publications

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .
    NADP sodium hydrate
  • HY-13543R

    DNA Alkylator/Crosslinker Cancer
    Tretazicar (Standard) is the analytical standard of Tretazicar. This product is intended for research and analytical applications. Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .
    Tretazicar (Standard)
  • HY-171035

    Quinone Reductase Keap1-Nrf2 Aminotransferases (Transaminases) Metabolic Disease
    PRL-295 is an orally active inhibitor targeting Keap1-Nrf2 interaction. PRL-295 increases the thermal stability of Keap1 and disrupts its interaction with Nrf2, thereby activating the Nrf2-dependent transcriptional target NAD(P)H:quinone oxidoreductase 1 (NQO1). PRL-295 protects against Acetaminophen (HY-66005)-induced liver injury in mice .
    PRL-295
  • HY-F0002A
    NADP disodium salt
    5+ Cited Publications

    Disodium NADP

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .
    NADP disodium salt
  • HY-P5381

    NADPH Oxidase Others
    gp91 ds-tat is a biological active peptide. (NADPH oxidase assembly peptide inhibitor)
    gp91 ds-tat
  • HY-128895A

    Mitochondrial Metabolism Quinone Reductase Metabolic Disease
    KL1333 hydrochloride is an orally active NAD + modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD + levels through NADH oxidation. Elevated NAD + levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures .
    KL1333 hydrochloride
  • HY-F0002R

    Sodium NADP (Standard)

    Endogenous Metabolite Reference Standards Metabolic Disease Inflammation/Immunology Cancer
    NADP (sodium salt) (Standard) is the analytical standard of NADP (sodium salt). This product is intended for research and analytical applications. NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4].
    NADP sodium salt (Standard)
  • HY-F0002AR

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    NADP (disodium salt) (Standard) is the analytical standard of NADP (disodium salt). This product is intended for research and analytical applications. NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .
    NADP disodium salt (Standard)
  • HY-12298
    Setanaxib
    25+ Cited Publications

    GKT137831; GKT831

    NADPH Oxidase Ferroptosis Cardiovascular Disease
    Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.
    Setanaxib
  • HY-P2800A

    Endogenous Metabolite Metabolic Disease
    Diaphorase from Clostridium sp. is responsible for catalyzing the oxidation of NADH or NADPH and is involved in regulating cellular energy metabolism .
    Diaphorase, clostridium sp.
  • HY-B0203B

    (Rac)-R 065824

    Adrenergic Receptor NADPH Oxidase Cardiovascular Disease
    (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
    (Rac)-Nebivolol
  • HY-125863B

    G6PD (yeast, recombinant)

    Endogenous Metabolite Cardiovascular Disease Metabolic Disease Cancer
    Glucose 6-phosphate dehydrogenase (yeast, recombinant) is the rate-limiting enzyme of the pentose phosphate pathway and a major source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, and cytochrome P450 systems. Glucose 6-phosphate dehydrogenase helps cells resist oxidative stress and regulates metabolic rates. It holds potential for research in fields such as diabetes, endothelial dysfunction, cancer, and cardiomyopathy .
    Glucose 6-phosphate dehydrogenase (yeast, recombinant)

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