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Results for "

voltage-gated

" in MedChemExpress (MCE) Product Catalog:

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239

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

KIO-301 chloride hydrochloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels) .

Ebio1	Potassium Channel	Others
Ebio1 is a selective voltage-gated potassium channel KCNQ2 activator. Ebio1 activates KCNQ2 by generating an extended channel gate with greater conductance at a saturation voltage (+50 mV) .

Phenytoin sodium 5 Publications Verification 5,5-Diphenylhydantoin sodium salt	Sodium Channel Virus Protease	Neurological Disease Cancer
Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na ⁺ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .

Phenytoin 5 Publications Verification 5,5-Diphenylhydantoin	Sodium Channel Virus Protease	Neurological Disease Cancer
Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na ⁺ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .

Vincanol (-)-Isoeburnamine; (-)-epi-Eburnamine	Sodium Channel	Neurological Disease
Vincanol ((-)-Isoeburnamine) is a blocker of voltage-gated Na+ channels. Vincanol blocks Na ⁺ currents with an IC₅₀ value of 40 μM. Vincanol has neuroprotective effect .

UK-59811 hydrochloride	Calcium Channel	Neurological Disease
UK-59811 hydrochloride, a Br-dihydropyridine derivative, is a potent bacterial homotetrameric model voltage-gated Ca ²⁺ (Ca_V) channel Ca_VAb inhibitor with an IC₅₀ of 194 nM .

Phrixotoxin 3	Sodium Channel	Neurological Disease
Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

Phrixotoxin 3 TFA	Sodium Channel	Neurological Disease
Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

KIO-301 chloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including *hyperpolarisation-activated cyclic nucleotide-gated* (HCN)** and voltage-gated potassium channels during exposure to visible light .

KC 12291 hydrochloride	Sodium Channel	Cardiovascular Disease
KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na ⁺ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo .

ztz240	Potassium Channel	Neurological Disease
ztz240 is a chemical modulator of voltage-gated potassium channel Kv7 (KCNQ) (KCNQ2 and 3: EC₅₀=6.1 μM; KCNQ4: EC₅₀=12.2 μM). ztz240 can be used in analgesia and anti-epileptic research .

Hainantoxin-IV HNTX-IV	Sodium Channel	Neurological Disease
Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .

Phenytoin (Standard) 5,5-Diphenylhydantoin (Standard)	Reference Standards Sodium Channel Virus Protease	Neurological Disease Cancer
Phenytoin (Standard) is the analytical standard of Phenytoin. This product is intended for research and analytical applications. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na ⁺ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .

Phenytoin sodium (Standard) 5,5-Diphenylhydantoin sodium salt (Standard)	Reference Standards Sodium Channel Virus Protease	Neurological Disease Cancer
Phenytoin (sodium) (Standard) is the analytical standard of Phenytoin (sodium). This product is intended for research and analytical applications. Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .

Phrixotoxin 3-NH2 TFA	Sodium Channel	Neurological Disease
Phrixotoxin 3-NH2 TFA is a derivative of Phrixotoxin 3 TFA (HY-P1218A). Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

Bimokalner Bimokalnerum	Potassium Channel	Neurological Disease
Bimokalner (Bimokalnerum) is a voltage-gated potassium channel (Kv7.4) agonist .

(R)-(+)-Bupivacaine hydrochloride	Sodium Channel	Neurological Disease
(R)-(+)-Bupivacaine hydrochloride is a voltage-gated sodium channel inhibitor. (R)-(+)-Bupivacaine hydrochloride can selectively block the voltage-gated sodium channels on nerve cell membranes, inhibit the influx of sodium ions, and thus prevent the generation and conduction of nerve impulses, exerting local anesthetic activity. (R)-(+)-Bupivacaine hydrochloride can be used in research of acute pains .

Jingzhaotoxin-II	Sodium Channel	Neurological Disease
Jingzhaotoxin-II, a 32 amino acid residues including two acidic and two basic residues, is a neurotoxin. Jingzhaotoxin-II inhibits voltage-gated sodium channels (VGSC) that significantly slows rapid inactivation of TTX-resistant (TTX-R) VGSC on cardiac myocytes with the IC₅₀ of 0.26 μM .

PD-85639	Sodium Channel	Neurological Disease
PD-85639 is a voltage-gated sodium (Na+) channel blocker that has neuroprotective effects .

Dendrotoxin-I DTX-I	Potassium Channel	Neurological Disease Cancer
Dendrotoxin-I (DTX-I) is a potent K ⁺ channels blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research .

Crisugabalin HSK16149	Calcium Channel	Neurological Disease
Crisugabalin (HSK16149) is a novel ligand of voltage-gated calcium channel (VGCC) α 2 δ subunit.

Veratridine 4 Publications Verification 3-Veratroylveracevine	Sodium Channel	Neurological Disease
Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC₅₀ of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow .

Jingzhaotoxin-IX	Sodium Channel	Neurological Disease
Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3 .

Dendrotoxin-I TFA DTX-I TFA	Potassium Channel	Cancer
Dendrotoxin-I (DTX-I) TFA is a potent K ⁺ channel blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6. Dendrotoxin-I TFA, a neurotoxin, has the potential for cancer research .

Licarbazepine 1 Publications Verification BIA 2-005; GP 47779	Sodium Channel	Neurological Disease
Licarbazepine (BIA 2-005; GP 47779) is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects .

Eslicarbazepine acetate BIA 2-093	Beta-secretase Sodium Channel	Neurological Disease
Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.

Calcium Channel antagonist 6	Calcium Channel	Neurological Disease
Calcium Channel antagonist 6 (Compound 328) is a highly selective antagonist of voltage-gated calcium channel CaV2.2 with an IC₅₀ value of 0.37 μM. Calcium Channel antagonist 6 inhibits of neuron depolarization-induced Ca ²⁺ influx. Calcium Channel antagonist 6 is promising for research of neuropathic pain .

ProTx-I	Calcium Channel Sodium Channel Potassium Channel	Cancer
ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective Ca_V3.1 channel blocker with IC₅₀ values of 0.2 μM and 31.8 μM for hCa_V3.1 and hCa_V3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na ⁺ channels and inhibits K_V 2.1 channels .

Nav1.7-IN-2	Sodium Channel	Neurological Disease
Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM.

S-Bioallethrin D-Trans-Allethrin; Esbiol	Sodium Channel	Neurological Disease
S-Bioallethrin (D-Trans-Allethrin) is a pyrethroid insecticide. S-Bioallethrin disrupts nerve function by modifying the gating kinetics of transitions between the conducting and nonconducting states of voltage-gated sodium channels. S-Bioallethrin also causes inhibition of lymphocyte proliferation and induces histamine release from human basophils .

Mepivacaine hydrochloride	Sodium Channel	Neurological Disease
Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization .

Benzocaine 1 Publications Verification	Sodium Channel Bacterial	Neurological Disease
Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na ⁺ channel, with an IC₅₀ of 0.8 mM tested with a potential of +30 mV.

Hymenidin	5-HT Receptor Potassium Channel	Cancer
Hymenidin is a natural antagonist of serotonergic receptor and inhibitor of voltage-gated potassium channels. Hymenidin also induces cancer cell apoptosis .

Calcium Channel antagonist 3	Calcium Channel	Neurological Disease
Calcium Channel antagonist 3 (compound 397) is an inhibitor of voltage-gated calcium channels with an IC₅₀ value of 5-20μM .

Sodium Channel inhibitor 1	Sodium Channel	Neurological Disease
Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.

Calcium Channel antagonist 4	Calcium Channel	Neurological Disease
Calcium Channel antagonist 4 (compound 189) is an inhibitor of voltage-gated calcium channels with an IC₅₀ value of 5-20μM .

Propoxycaine hydrochloride 1 Publications Verification	Sodium Channel	Neurological Disease
Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses. Propoxycaine hydrochloride application can lead to a loss of sensation.

Dehydrocrenatidine Kumujian G; O-Methylpicrasidine I	JAK Apoptosis	Neurological Disease Cancer
Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain .

Amifampridine 3,4-Diaminopyridine	Potassium Channel	Neurological Disease
Amifampridine (3,4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (K_v) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research .

Amifampridine phosphate 3,4-Diaminopyridine phosphate	Potassium Channel	Neurological Disease
Amifampridine (3,4-Diaminopyridine) phosphate is an orally active, potent and cell permeable voltage-gated potassium (K_v) channel blocker (PCB). Amifampridine phosphate is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine phosphate increases transmitter release from neuromuscular junctions (NMJs). Amifampridine phosphate can be used for Lambert-Eaton myasthenic syndrome (LEMS) research .

Corza6	Proton Pump Reactive Oxygen Species (ROS)	Metabolic Disease
Corza6 is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 binds to the external voltage sensor domain (VSD) loop in hHv1 with a K_d of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) .

Veratridine (Standard) 3-Veratroylveracevine (Standard)	Reference Standards Sodium Channel	Neurological Disease
Veratridine (Standard) is the analytical standard of Veratridine. This product is intended for research and analytical applications. Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC₅₀ of 18.39?μM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow .

Nisoxetine 1 Publications Verification	Monoamine Transporter Sodium Channel	Neurological Disease
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a K_d of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .

Nisoxetine hydrochloride 1 Publications Verification	Monoamine Transporter Sodium Channel	Neurological Disease
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a K_d of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .

Cat. No.	Product Name

HY-L118

Sodium Channel Blocker Library

169 compounds

Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion.

MCE offers a unique collection of 169 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

HY-L0104V

UORSY New Generation Screening Library

1,900,000 compounds

UORSY New Generation Screening Library contains about 1,900,000 compounds. The library is a revolutionary collection of lead-like molecules with outstanding structural quality and diversity—New Generation Screening Library (NGSL). Its core is decorated with interesting building blocks, including important medicinal fragments such as peptide bonds, amino groups and hydroxyl groups. and designed for discovery of new Voltage-gated calcium channel blockers.

HY-L119

Potassium Channel Compound Library

288 compounds

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. There are four major classes of K channels: voltage-gated potassium channel, calcium-activated potassium channel, inwardly rectifying potassium channel and tandem pore domain potassium channel. There is growing evidence that dysfunction in potassium channels correlates with several diseases, such as chronic hypertension, diabetes, hypercholesterolemia and atherosclerosis, etc.

MCE Potassium Channel Compound Library consists of 288 potassium channel inhibitor and activators, which is a useful tool to discover drugs for cardiovascular diseases and potassium channel research.

HY-L165

Dopamine Receptor Compound Library

246 compounds

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life.

MCE designs a unique collection of 246 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Cat. No.	Product Name	Type

HY-129763

Di-4-ANEPPS

Dyes

Di-4-ANEPPS is a voltage-sensitive dye that acts on voltage-gated ion channels (such as sodium channels) and inhibits sodium current, significantly reducing sodium current density, although specific values like IC₅₀ remain unclear. It mainly binds to the voltage-sensitive regions on the cell membrane, changing its fluorescence properties to reflect membrane potential changes and thus affecting the function of ion channels to exert its activity. This substance can be used in cardiovascular research, such as the electrophysiology of cardiomyocytes, myocardial ischemia, and the effects of drugs on cardiomyocytes. It is of great value in evaluating drug cardiotoxicity and exploring the mechanisms of arrhythmias .

HY-D2266

FluoBar1	Fluorescent Dyes/Probes
FluoBar1 is an imaging fluorescence probe modified by a barbiturate ligand with fluorescent coumarin. FluoBar1 can monitor L-type voltage-gated calcium channels (LTCC) in living cells in real time for the study of neurological diseases .

Cat. No.	Product Name	Type

HY-Y0537E

Potassium chloride, for cell culture

Buffer Reagents

Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells .

HY-170424

D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium	Drug Delivery
D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium increases the extracellular Ca ²⁺ entry through upregulation of voltage-gated calcium channels .

Cat. No.	Product Name	Target	Research Area

HY-P1218B

Phrixotoxin 3-NH2 TFA	Sodium Channel	Neurological Disease
Phrixotoxin 3-NH2 TFA is a derivative of Phrixotoxin 3 TFA (HY-P1218A). Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

HY-P3055A

Dendrotoxin-I TFA DTX-I TFA	Potassium Channel	Cancer
Dendrotoxin-I (DTX-I) TFA is a potent K ⁺ channel blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6. Dendrotoxin-I TFA, a neurotoxin, has the potential for cancer research .

HY-P1218

Phrixotoxin 3	Sodium Channel	Neurological Disease
Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

HY-P1218A

Phrixotoxin 3 TFA	Sodium Channel	Neurological Disease
Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

HY-P5184

Hainantoxin-IV HNTX-IV	Sodium Channel	Neurological Disease
Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .

HY-P5772

Jingzhaotoxin-II	Sodium Channel	Neurological Disease
Jingzhaotoxin-II, a 32 amino acid residues including two acidic and two basic residues, is a neurotoxin. Jingzhaotoxin-II inhibits voltage-gated sodium channels (VGSC) that significantly slows rapid inactivation of TTX-resistant (TTX-R) VGSC on cardiac myocytes with the IC₅₀ of 0.26 μM .

HY-P3055

Dendrotoxin-I DTX-I	Potassium Channel	Neurological Disease Cancer
Dendrotoxin-I (DTX-I) is a potent K ⁺ channels blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research .

HY-P5771

Jingzhaotoxin-IX	Sodium Channel	Neurological Disease
Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3 .

HY-P1073

ProTx-I	Calcium Channel Sodium Channel Potassium Channel	Cancer
ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective Ca_V3.1 channel blocker with IC₅₀ values of 0.2 μM and 31.8 μM for hCa_V3.1 and hCa_V3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na ⁺ channels and inhibits K_V 2.1 channels .

HY-P10817

Corza6	Proton Pump Reactive Oxygen Species (ROS)	Metabolic Disease
Corza6 is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 binds to the external voltage sensor domain (VSD) loop in hHv1 with a K_d of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) .

HY-P5869

Kurtoxin	Calcium Channel Sodium Channel	Neurological Disease
Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca ²⁺ channel gating inhibitor with a K_d of 15 nM for Cav3.1 (α1G T-type) Ca ²⁺ channel. Kurtoxin can interact with high affinity with native neuronal high-threshold L-type, N-type, and P-type Ca ²⁺ channels in central and peripheral neurons. Kurtoxin also shows cross-reactivity with voltage-gated Na ⁺ channel .

HY-P10817A

Corza6 TFA	Proton Pump Reactive Oxygen Species (ROS)	Metabolic Disease
Corza6 TFA is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 TFA binds to the external voltage sensor domain (VSD) loop in hHv1 with a K_d of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 TFA allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) .

HY-P5921

Tityustoxin-Kα TsTx-Kα	Potassium Channel	Neurological Disease
Tityustoxin-Kα (TsTx-Kα) is an inhibitor of *potassium voltage-gated* channels**. Tityustoxin-Kα shows a dose-dependent block of the sustained outward current in cultured hippocampal neurons .

HY-P5142

ω-Hexatoxin-Hv1a ω-ACTX-Hv1; ω-Atracotoxin-HV1	Calcium Channel	Neurological Disease
ω-Hexatoxin-Hv1a is a neurotoxin that can be isolated from the venom spider (Hadronyche versuta).ω-Hexatoxin-Hv1a blocks voltage-gated calcium channels .

HY-P4742A

6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) (TFA) 6-FAM-AEEAC-SHK TFA	Biochemical Assay Reagents Potassium Channel	Neurological Disease
6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA (6-FAM-AEEAC-SHK TFA) is a peptide neurotoxin conjugated with a fluorescent marker. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can block voltage-gated potassium channels (kv1.1 and kv1.2) to prolong the duration of action potentials, thereby affecting the conduction of neural signals. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can be used in neuroscience research .

HY-P10234

Poneratoxin	Sodium Channel	Neurological Disease
Poneratoxin is the modulator for voltage-gated sodium channel (NaV, EC₅₀ for NaV1.6 and NaV1.7 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals .

HY-P5179

Huwentoxin I HWTX-I	Calcium Channel Sodium Channel	Neurological Disease
Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC₅₀ values of 66.1 and 4.80 nM, respectively .

HY-P5810

Ceratotoxin-2 CcoTx2; β-TRTX-cm1b	Sodium Channel	Neurological Disease
Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel blocker with IC₅₀s of 8 nM and 88 nM against Na_v1.2/β₁ and Na_v1.3/β₁, respectively .

HY-N6708

Alamethicin 1 Publications Verification	Antibiotic Bacterial	Infection
Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .

HY-P5868

mHuwentoxin-IV	Sodium Channel	Neurological Disease
mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC₅₀ of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages .

HY-P5807A

Cn2 toxin TFA β-Mammal toxin Cn2 TFA	Sodium Channel	Neurological Disease
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6 .

HY-P2699

ω-Grammotoxin SIA GrTx; ω-GsTx SIA	Calcium Channel	Neurological Disease
ω-Grammotoxin SIA (GrTx) is P/Q and N-type voltage-gated Calcium channels inhibitor. ω-Grammotoxin SIA is also a protein toxin that can be obtained from spider venom. ω-Grammotoxin SIA has the potential to study neurological diseases as well as cardiovascular diseases .

HY-P10234A

Poneratoxin acetate 1 Publications Verification	Sodium Channel	Neurological Disease
Poneratoxin acetate is the acetate salt form of Poneratoxin (HY-P10234). Poneratoxin acetate is the modulator for voltage-gated sodium channel (NaV, EC₅₀ for NaV1.6 and NaV1.7 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals .

HY-P5152

Scorpion toxin Tf2	Sodium Channel	Neurological Disease
Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials .

HY-P1427A

Guangxitoxin 1E TFA	Potassium Channel	Neurological Disease
Guangxitoxin 1E TFA is the TFA salt form of Guangxitoxin 1E (HY-P1427). Guangxitoxin 1E TFA is a peptide toxin and a selective inhibitor for voltage-gated potassium channel K_V2.1 and K_V2.2 with IC₅₀ of 1-3 nM. Guangxitoxin 1E TFA enhances glucose-stimulated intracellular calcium ion oscillations and increases insulin secretion in a glucose-dependent manner .

HY-P5153

ProTx-III μ-TRTX-Tp1a	Sodium Channel	Neurological Disease
ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Na_v1.7, with an IC₅₀ of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia .

HY-P5807

Cn2 toxin β-Mammal toxin Cn2	Sodium Channel	Neurological Disease
Cn2 toxin is aβ- toxoins. Cn2 toxin can bind to the voltage sensing domain of voltage gated sodium channels (Na_v) .

HY-P5870

KTX-Sp2	Potassium Channel	Inflammation/Immunology
KTX-Sp2 is a potassium channel toxin. KTX-Sp2 effectively blocks three types of exogenous voltage-gated potassium channels: Kv1.1, Kv1.2 and Kv1.3. Ktx-Sp2 inhibits endogenous Kv1.3 and suppresses Ca ²⁺ signaling in Jurkat T cells. Ktx-Sp2 inhibits IL-2 secretion from activated Jurkat T cells .

HY-P5925A

Ssm spooky toxin TFA SsTx Toxin TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
Ssm Spooky Toxin TFA is found in Scolopendra mutilans that potently inhibits *KCNQ (voltage-gated* potassium channel family 7) channels, with IC₅₀**s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin TFA inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin TFA plays an essential role in the centipede’s circulatory system .

HY-P5925

Ssm spooky toxin SsTx Toxin	Potassium Channel	Neurological Disease Inflammation/Immunology
Ssm Spooky Toxin is found in Scolopendra mutilans that potently inhibits *KCNQ (voltage-gated* potassium channel family 7) channels, with IC₅₀**s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin plays an essential role in the centipede’s circulatory system .

HY-P5811

Ceratotoxin-1 CcoTx1; β-TRTX-cm1a	Sodium Channel	Neurological Disease
Ceratotoxin-1 (CcoTx1), a peptide toxin, is an voltage-gated sodium channel subtypes inhibitor. Ceratotoxin-1 inhibits Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1 with IC₅₀ of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Ceratotoxin-1 also inhibits Nav1.8/β1 .

HY-P1651

SOR-C13	TRP Channel	Cancer
SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC₅₀ value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 has anticancer activity .

HY-P1651A

SOR-C13 TFA	TRP Channel	Cancer
SOR-C13 TFA, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC₅₀ value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 TFA has anticancer activity .

HY-P1078

Huwentoxin XVI	Calcium Channel	Neurological Disease
Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC₅₀ of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels .

HY-P1078A

Huwentoxin XVI TFA	Calcium Channel	Neurological Disease
Huwentoxin XVI TFA, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC₅₀ of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI TFA has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels .

Species:	Human (5)
Tag:	GFP (1) His (2) SUMO (1) Tag Free (2)
Source:	HEK293 (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P703157

	KCNA3 Protein, Human (HEK293) voltage-gated potassium channel KCNC1; NGK2; Potassium voltage-gated channel subfamily C member 1; voltage-gated potassium channel subunit Kv3.1; voltage-gated potassium channel subunit Kv4; KCNC1; Homo sapiens; Human; Ion channel; Potassium channel; voltage-gated channel	Human	HEK293
	KCNA3 Protein, Human (HEK293) is the recombinant human-derived KCNA3, expressed by HEK293 , with tag Free labeled tag. ,

HY-P703261

	KCNQ4 Protein, Human (HEK293) Potassium voltage-gated channel subfamily KQT member 4; KQT-like 4; Potassium channel subunit alpha KvLQT4; voltage-gated potassium channel subunit Kv7.4; KCNQ4; Homo sapiens; Human; Ion channel; Potassium channel; voltage-gated channel;	Human	HEK293
	KCNQ4 Protein, Human (HEK293) is the recombinant human-derived KCNQ4, expressed by HEK293 , with tag Free labeled tag. ,

HY-P703937

	hERG Protein, Human (HEK293) voltage-gated inwardly rectifying potassium channel KCNH2; Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Potassium voltage-gated channel subfamily H member 2; voltage-gated potassium channel subunit Kv11.1	Human	HEK293
	The hERG protein is the α subunit of voltage-gated potassium channels and is critical for mediating cardiac delayed rectifier potassium current (IKr). It lacks individual channel activity but dynamically affects properties by forming heterotetramers with other isoforms. hERG Protein, Human (HEK293) is the recombinant human-derived hERG protein, expressed by HEK293, with tag free.

HY-P701834

	hERG Protein, Human (HEK293, GFP, His) KCNH2; Potassium voltage-gated channel subfamily H member 2; Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; voltage-gated potassium channel subunit Kv11.1	Human	HEK293
	The hERG protein is the α subunit of voltage-gated potassium channels and is critical for mediating cardiac delayed rectifier potassium current (IKr). It lacks individual channel activity but dynamically affects properties by forming heterotetramers with other isoforms. hERG Protein, Human (HEK293, GFP, His) is the recombinant human-derived hERG protein, expressed by HEK293 , with C-10*His, C-GFP labeled tag.

HY-P72109

	CACNA2D1 Protein, Human (His-SUMO) CA2D1_HUMAN; CACN A2; CACNA2; Cacna2d1; CACNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta; L type calcium channel subunit alpha 2; MHS 3; MHS3; voltage dependent calcium channel subunit alpha 2/delta 1; voltage gated calcium channel subunit alpha 2/delta 1; voltage-dependent calcium channel subunit delta-1; voltage-gated calcium channel subunit alpha-2/delta-1	Human	E. coli
	The CACNA2D1 protein, particularly its α-2/δ subunit, plays a key role in regulating calcium current density and activation/deactivation kinetics of voltage-dependent calcium channels. It contributes to excitation-contraction coupling, coordinating cellular processes. CACNA2D1 Protein, Human (His-SUMO) is the recombinant human-derived CACNA2D1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-108506S1

Licarbazepine-d4
Licarbazepine-d₄ is the deuterium labeled Licarbazepine (HY-108506). Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects .

HY-A0093S

Mexiletine-d6 hydrochloride
Mexiletine-d₆ (hydrochloride) is a deuterium labeled Mexiletine hydrochloride (KOE-1173 hydrochloride). Mexiletine hydrochloride, a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker .

HY-Y0258S

Benzocaine-d4
Benzocaine-d₄ is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.

HY-Y0258S1

Benzocaine-(ethyl-d5)
Benzocaine-(ethyl-d₅) is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.

HY-B0517S

Mepivacaine-d3
Mepivacaine-d₃ is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization .

HY-108506S

Licarbazepine-d3
Licarbazepine-d₃ is the deuterium labeled Licarbazepine (HY-108506). Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects .

HY-A0093S1

Mexiletine-d3 hydrochloride
Mexiletine-d₃ (hydrochloride) is deuterium labeled Mexiletine (hydrochloride). Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1][2].

HY-B0703S

Eslicarbazepine acetate-d4
Eslicarbazepine acetate-d₄ is deuterated labeled Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.

HY-W744263

Eslicarbazepine Acetate-d3
Eslicarbazepine Acetate-d₃ is the deuterium labeled Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.

HY-B0448S

Phenytoin-d10
Phenytoin-d₁₀ is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .

HY-B0339S

Primidone-d5
Primidone-d₅ is the deuterium labeled Primidone. Primidone is the orally active inhibitor for TRPM3 (IC₅₀ = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent .

HY-B0448S1

Phenytoin-15n2,13c
Phenytoin- ¹⁵N₂, ¹³C is the ¹³C and ¹⁵N labeled Phenytoin . Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .

HY-B0448S2

Phenytoin-d5
Phenytoin-d₅ (5,5-Diphenylhydantoin-d₅) is deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na ⁺ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .

HY-B0495S5

Lamotrigine-d3
Lamotrigine-d₃ is the deuterium labeled Lamotrigine . Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .

HY-B0495S4

Lamotrigine-13C3
Lamotrigine- ¹³C₃ is the ¹³C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .

HY-B0495S7

Lamotrigine-13C
Lamotrigine- ¹³C (LTG- ¹³C) is ¹³C labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na ⁺ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .

HY-W701464

N-Desalkylflurazepam-d4
N-Desalkylflurazepam-d₄ is a deuterated labeled N-Desalkylflurazepam (HY-106454). N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC₅₀ values of 55 μM and 37 μM for Ca_v1.2 and Ca_v1.3, respectively .

HY-B0495S1

Lamotrigine-13C,d3
Lamotrigine- ¹³C,d₃ is the ¹³C- and deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .

HY-B0495S3

Lamotrigine-13C2,15N
Lamotrigine- ¹³C₂, ¹⁵N is the ¹³C and ¹⁵N labeled Lamotrigine . Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .

HY-B0495S

Lamotrigine-13C3,d3
Lamotrigine- ¹³C₃,d₃ is the ¹³C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .

HY-B0495S8

Lamotrigine-13C7,15N

Lamotrigine- ¹³C₇, ¹⁵N (LTG- ¹³C₇, ¹⁵N) is ¹³C and ¹⁵N labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na ⁺ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .

HY-W707161

4-Methyl-2-(1-piperidinyl)-quinoline-d10
4-Methyl-2-(1-piperidinyl)-quinoline-d₁₀ is the deuterium labeled ML204 (HY-12949). ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels .

HY-14946S

Amifampridine-d3

Amifampridine-d₃ (3,4-Diaminopyridine-d₃) is deuterium labeled Amifampridine. Amifampridine (3,4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (K_v) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research .

HY-13295S

Vinpocetine-d5

Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-B0495S6

Lamotrigine-13C2,15N2,d3

Lamotrigine- ¹³C₂, ¹⁵N₂,d₃ is ¹⁵N and deuterated labeled Lamotrigine (HY-B0495). Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na ⁺ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .

HY-A0082S

Diphenidol-d10 hydrochloride

Diphenidol-d₁₀ (hydrochloride) (Difenidol hydrochloride-d₁₀) is deuterium labeled Diphenidol (hydrochloride). Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M₁-M₄ receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na ⁺, K ⁺, and Ca ²⁺) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea .

HY-119980BS

Fluphenazine-d6 hydrochloride

Fluphenazine-d₆ (hydrochloride) is deuterium labeled Fluphenazine (hydrochloride). Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-119980S

Fluphenazine-d8

Fluphenazine-d₈ is the deuterium labeled Fluphenazine. Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-108506S2

Licarbazepine-d4-1
Licarbazepine-d₄-1 is deuterium labeled Licarbazepine. Licarbazepine (BIA 2-005; GP 47779)?is a?voltage-gated sodium channel?blocker?with?anticonvulsant?and?mood-stabilizing?effects .

HY-108506S4

Licarbazepine-d8
Licarbazepine-d₈ (BIA 2-005-d₈) is deuterium labeled Licarbazepine. Licarbazepine (BIA 2-005; GP 47779)?is a?voltage-gated sodium channel?blocker?with?anticonvulsant?and?mood-stabilizing?effects .

HY-132184S

5,6-Epoxyeicosatrienoic acid-d11

5,6-Epoxyeicosatrienoic acid-d₁₁ (5,6-EET-d₁₁) is deuterium labeled 5,6-Epoxyeicosatrienoic acid. 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC₅₀=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5,6-Epoxyeicosatrienoic acid is provided as a mixture of the free acid and lactone .

HY-B0768S

Lomerizine-d4
Lomerizine-d4 is the deuterium labeled Lomerizine (HY-B0768). Lomerizine is an antagonist of L- and *T-type voltagegated* calcium channels** .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83330

	KCNA1 Antibody (YA3075) KCNA1; Potassium voltage-gated channel subfamily A member 1; voltage-gated K(+) channel HuKI; voltage-gated potassium channel HBK1; voltage-gated potassium channel subunit Kv1.1	WB, IP	Human
	KCNA1 Antibody (YA3075) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KCNA1.

HY-P86930

	KCNA5/KV1-5 Antibody (YA6623) ATFB7 antibody; cardiac potassium channel antibody; HCK1 antibody; HK2 antibody; HPCN1 antibody; insulinoma and islet potassium channel antibody; KCNA5 antibody; KCNA5_HUMAN antibody; KV1.5 antibody; PCN1 antibody; ATFB7 antibody; cardiac potassium channel antibody; HCK1 antibody; HK2 antibody; HPCN1 antibody; insulinoma and islet potassium channel antibody; KCNA5 antibody; KCNA5_HUMAN antibody; KV1.5 antibody; PCN1 antibody; potassium channel 1 antibody; Potassium channel, insulinoma and islet cell antibody; Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody; Potassium voltage gated channel subfamily A member 5 antibody; Potassium voltage-gated channel subfamily A member 5 antibody; voltage-gated potassium channel HK2 antibody; voltage-gated potassium channel protein Kv1.5 antibody; voltage-gated potassium channel subunit Kv1.5 antibody;	WB	Human, Mouse, Rat
	KCNA5/KV1-5 Antibody (YA6623) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KCNA5/KV1-5.

HY-P86936

	Kv4.2/KCND2 Antibody (YA6629) KCD2 antibody; KCND 2 antibody; KCND2 antibody; KCND2_HUMAN antibody; KIAA1044 antibody; MGC119702 antibody; MGC119703 antibody; Potassium voltage gated channel Shal related subfamily member 2 antibody; Potassium voltage-gated channel subfamily D member 2 antibody; RK 5 antibody; KCD2 antibody; KCND 2 antibody; KCND2 antibody; KCND2_HUMAN antibody; KIAA1044 antibody; MGC119702 antibody; MGC119703 antibody; Potassium voltage gated channel Shal related subfamily member 2 antibody; Potassium voltage-gated channel subfamily D member 2 antibody; RK 5 antibody; RK5 antibody; voltage gated potassium channel Kv4.2 antibody; voltage gated potassium channel subunit Kv4.2 antibody; voltage sensitive potassium channel antibody; voltage-gated potassium channel subunit Kv4.2 antibody;	IHC-F, IHC-P, WB	Mouse, Rat
	Kv4.2/KCND2 Antibody (YA6629) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Kv4.2/KCND2.

HY-P86255

	CACNA1F Antibody (YA5947) CACNA1F; CACNAF1; voltage-dependent L-type calcium channel subunit alpha-1F ; voltage-gated calcium channel subunit alpha Cav1.4;	WB, FC	Human
	CACNA1F Antibody (YA5947) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CACNA1F.

HY-P86832

	CaV2.3/CACNA1E Antibody (YA6525) alpha-1 polypeptide antibody; BII antibody; Brain calcium channel II antibody; CAC 1E antibody; CAC1E antibody; CAC1E_HUMAN antibody; CACH 6 antibody; CACH6 antibody; CACNA1E antibody; Cacnl1 a6 antibody; alpha-1 polypeptide antibody; BII antibody; Brain calcium channel II antibody; CAC 1E antibody; CAC1E antibody; CAC1E_HUMAN antibody; CACH 6 antibody; CACH6 antibody; CACNA1E antibody; Cacnl1 a6 antibody; CACNL1A6 antibody; Calcium channel antibody; Calcium channel, L type, alpha 1 polypeptide, isoform 6 antibody; calcium channel, R type antibody; Cav 2.3 antibody; Cchra 1 antibody; Cchra1 antibody; isoform 6 antibody; L type antibody; voltage dependent R type calcium channel subunit alpha 1E antibody; voltage gated calcium channel subunit alpha Cav2.3 antibody; voltage-dependent R-type calcium channel subunit alpha-1E antibody; voltage-gated calcium channel subunit alpha Cav2.3 antibody;	IHC-F, IHC-P, WB	Mouse, Rat
	CaV2.3/CACNA1E Antibody (YA6525) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaV2.3/CACNA1E.