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  4. KCNQ4 Protein, Human (HEK293)

KCNQ4 Protein, Human (HEK293) is the recombinant human-derived KCNQ4, expressed by HEK293 , with tag Free labeled tag. ,

For research use only. We do not sell to patients.

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Description

KCNQ4 Protein, Human (HEK293) is the recombinant human-derived KCNQ4, expressed by HEK293 , with tag Free labeled tag. ,
Background

KCNQ4 is the pore-forming subunit of the voltage-gated potassium (Kv) channel that regulates the excitability of sensory cells in the cochlea. The KCNQ4/Kv7.4 channel consists of four pore-forming subunits assembled as tetramers, facilitating potassium ion efflux during the repolarization phase of action potentials to modulate membrane potential in excitable cells. This channel conducts slowly activating and deactivating currents, often exhibiting inward rectification at positive potentials. In vitro studies suggest selectivity for other cations beyond potassium, with affinity ranking K(+) = Rb(+) > Cs(+) > Na(+). KCNQ4 is critical for normal inner ear functions, including sound perception.
Species

Human
Source

HEK293
Tag

Tag Free
Accession

P56696-1 (M1-D695)
Gene ID

9132
Protein Length

Full Length of Isoform-1
Synonyms
Potassium voltage-gated channel subfamily KQT member 4; KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4; KCNQ4; Homo sapiens; Human; Ion channel; Potassium channel; Voltage-gated channel;
Predicted Molecular Mass
77.2 kDa
Purity

Greater than 80% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

KCNQ4 Protein, Human (HEK293) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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