hERG Protein, Human (HEK293)

The hERG protein is the α subunit of voltage-gated potassium channels and is critical for mediating cardiac delayed rectifier potassium current (IKr). It lacks individual channel activity but dynamically affects properties by forming heterotetramers with other isoforms. hERG Protein, Human (HEK293) is the recombinant human-derived hERG protein, expressed by HEK293, with tag free.

hERG, the pore-forming α subunit of the voltage-gated inwardly rectifying potassium channel, plays a pivotal role in mediating the rapidly activating component of the delayed rectifying potassium current in the heart (IKr). While it lacks channel activity on its own, hERG dynamically influences channel properties through the formation of heterotetramers with other isoforms. This subunit assembly not only modulates the channel characteristics but also leads to the intracellular retention of the heterotetramers, subsequently undergoing ubiquitin-dependent degradation. The intricate interplay of hERG with other isoforms highlights its regulatory function in the finely tuned orchestration of potassium currents crucial for cardiac physiology.

Human

HEK293

Tag Free

Q12809-1 (M1-S1159, ΔP141-A350 and ΔS871-R1005)

3757

Full Length of Isoform-1

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.