2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Crisugabalin

Crisugabalin (HSK16149) is a novel ligand of voltage-gated calcium channel (VGCC) α 2 δ subunit.

For research use only. We do not sell to patients.

Crisugabalin

Crisugabalin Chemical Structure

CAS No. : 2209104-84-5

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Based on 1 publication(s) in Google Scholar

Crisugabalin Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

Crisugabalin (HSK16149) is a novel ligand of voltage-gated calcium channel (VGCC) α 2 δ subunit.

Clinical Trial
Molecular Weight

209.28

Formula

C12H19NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C[C@@]1(CN)[C@](C2)([H])[C@@]3([H])C[C@]2([H])CC[C@@]13[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (477.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7783 mL 23.8914 mL 47.7829 mL
5 mM 0.9557 mL 4.7783 mL 9.5566 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7783 mL 23.8914 mL 47.7829 mL 119.4572 mL
5 mM 0.9557 mL 4.7783 mL 9.5566 mL 23.8914 mL
10 mM 0.4778 mL 2.3891 mL 4.7783 mL 11.9457 mL
15 mM 0.3186 mL 1.5928 mL 3.1855 mL 7.9638 mL
20 mM 0.2389 mL 1.1946 mL 2.3891 mL 5.9729 mL
25 mM 0.1911 mL 0.9557 mL 1.9113 mL 4.7783 mL
30 mM 0.1593 mL 0.7964 mL 1.5928 mL 3.9819 mL
40 mM 0.1195 mL 0.5973 mL 1.1946 mL 2.9864 mL
50 mM 0.0956 mL 0.4778 mL 0.9557 mL 2.3891 mL
60 mM 0.0796 mL 0.3982 mL 0.7964 mL 1.9910 mL
80 mM 0.0597 mL 0.2986 mL 0.5973 mL 1.4932 mL
100 mM 0.0478 mL 0.2389 mL 0.4778 mL 1.1946 mL
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Crisugabalin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crisugabalin2209104-84-5HSK16149HSK 16149HSK-16149Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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