Search Result

Results for "

osteoblast

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (5) Apoptosis (10) Aryl Hydrocarbon Receptor (2) Autophagy (4) Bacterial (4) Caspase (2) CDK (2) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (2) Dopamine β-hydroxylase (1) EBV (1) Endogenous Metabolite (3) Epigenetic Reader Domain (1) ERK (6) Estrogen Receptor/ERR (2) FAK (1) Fluorescent Dye (3) GABA Receptor (1) Glutaminase (1) Glycosidase (1) HIF/HIF Prolyl-Hydroxylase (4) Influenza Virus (1) Integrin (2) Interleukin Related (2) Isotope-Labeled Compounds (1) JAK (1) JNK (1) Keap1-Nrf2 (1) Kisspeptin Receptor (2) Macrophage migration inhibitory factor (MIF) (1) mGluR (1) Microtubule/Tubulin (1) MMP (2) Monoamine Oxidase (1) Necroptosis (3) NF-κB (5) NO Synthase (2) NOD-like Receptor (NLR) (1) Orexin Receptor (OX Receptor) (2) p38 MAPK (4) Parasite (2) PERK (2) Phosphatase (7) Phosphodiesterase (PDE) (1) PKA (1) PPAR (2) Prostaglandin Receptor (1) PTHR (1) RANKL/RANK (1) Reactive Oxygen Species (3) Reference Standards (1) RXFP Receptor (1) TGF-beta/Smad (1) TGF-β Receptor (1) Thyroid Hormone Receptor (2) TNF Receptor (2) Tyrosinase (1) Wnt (12) Zinc Finger Protein (1) β-catenin (5)
By Research Areas:	Cancer (25) Cardiovascular Disease (7) Endocrinology (5) Infection (7) Inflammation/Immunology (16) Metabolic Disease (38) Neurological Disease (12)
Oligonucleotides:	CpG ODNs (4) Sweetening Agents (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Syringetin	Others	Metabolic Disease
Syringetin, a flavonoid derivative, is associated with increased BMP-2 production. Syringetin stimulates osteoblast differentiation at various stages, from maturation to terminally differentiated osteoblasts .

Orcinol glucoside	Wnt	Neurological Disease
Orcinol glucoside (OG) is an active constituent isolated from Curculigo orchioides, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway .

BMP agonist 2	TGF-β Receptor	Others
BMP agonist 2 (derivative I-9) is a potent bone-inducing cytokine. BMP agonist 2 promotes bone tissue production by increasing the proportion and activity of osteoblasts. BMP agonist 2 promotes osteoblast proliferation and differentiation through the BMP2-ATF4 signaling axis, in which ATF4 is a transcription factor closely related to osteoblast differentiation and bone formation. BMP agonist 2 can be used in the study of senile osteoporosis (SOP) .

Curculigoside B	Others	Others
Curculigoside B, a phenolic glycoside isolated from Curculigo orchioides, enhances the osteoblast proliferation, decreases the area of bone resorption pit, osteoclastic formation and TRAP activity. Antiosteoporotic and antioxidative activities .

NC9 Cbz-Lys(Acr)-PEG2-dansyl	Glutaminase Microtubule/Tubulin	Others
NC9 (Cbz-Lys(Acr)-PEG2-dansyl) is an irreversible transglutaminase (TG) inhibitor. NC9 inhibits osteoblast differentiation and mineralization. NC9 destabilizes microtubules. NC9 can be used for the research of osteoblast differentiation .

Trifloroside	MMP	Metabolic Disease
Trifloroside is a secoiridoid glycoside with antioxidant effects. Trifloroside induces osteogenic effects through osteoblast differentiation, adhesion, migration, and mineral apposition. Trifloroside has the potential for osteoblast-mediated bone diseases research .

Bullatantriol (+)-Bullatantriol	Others	Inflammation/Immunology
Bullatantriol ((+)?-?Bullatantriol) can be isolated from the roots of Homalomena aromatica. Bullatantriol can promote the proliferation and differentiation of osteoblasts. Bullatantriol also inhibits LPS-induced NO production in BV2 cells .

VnP-16	Integrin FAK	Inflammation/Immunology
VnP-16 can promote bone formation by accelerating osteoblast differentiation and activity through direct interaction with β1 integrin followed by FAK activation .

SPA0355	RANKL/RANK p38 MAPK Akt NF-κB	Inflammation/Immunology
SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor κB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs, Akt, and NF-κB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis .

Orcinol glucoside (Standard)	Wnt	Neurological Disease
Orcinol glucoside (Standard) is the analytical standard of Orcinol glucoside. This product is intended for research and analytical applications. Orcinol glucoside (OG) is an active constituent isolated from Curculigo orchioides, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway .

UBS109	NF-κB	Others
UBS109, as a curcumin analogue, can promote the differentiation and mineralization of osteoblasts. UBS109 shows to regulate bone cell function by activating Smad and inhibiting NF-kB. UBS109 can be used in bone tissue engineering and osteoporosis research .

Toddaculin	Apoptosis	Cardiovascular Disease
Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity .

S24–14	Others	Metabolic Disease
S24–14 is a potent antiosteoporosis agent. S24–14 inhibits osteoclastogenesis with an IC₅₀ value of 0.40 µM. S24–14 induces osteoblast differentiation. S24–14 suppresses bone loss .

Paeonoside	Others	Infection Metabolic Disease Inflammation/Immunology
Paeonoside is a bioactive compound identified in P. suffruticosa that promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality .

KY-02327 acetate	Wnt	Metabolic Disease
KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .

KY-02327	Wnt	Metabolic Disease
KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .

Cyclamic acid sodium Sodium cyclamate; Cyclohexylsulfamic acid sodium	Necroptosis Apoptosis	Metabolic Disease Cancer
Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

Alizarin Red S ARS	Fluorescent Dye	Others
Alizarin Red S (ARS) is an anthraquinone derivative dye. When combined with cations such as calcium ions, the functional group of Alizarin Red S can form a coordination bond with the cation through the oxygen atom to show orange-red fluorescence. Alizarin Red S can be used for screening of calcium compounds in synovial fluid and detecting osteoblast differentiation, and can also be used for bone staining in mice. Excitation/emission wavelength: 500/570 nm .

Alizarin Red S sodium 5+ Cited Publications ARS sodium	Fluorescent Dye	Others
Alizarin Red S sodium is an anthraquinone derivative dye. When combined with cations such as calcium ions, the functional group of Alizarin Red S sodium can form a coordination bond with the cation through the oxygen atom to show orange-red fluorescence. Alizarin Red S sodium can be used for screening of calcium compounds in synovial fluid and detecting osteoblast differentiation, and can also be used for bone staining in mice. Excitation/emission wavelength: 500/570 nm .

Dentonin TFA AC-100 TFA	Integrin	Metabolic Disease
Dentonin TFA (AC-100 TFA) is a synthetic fragment derived from MEPE. Dentonin TFA enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin TFA has no significant effect to mature osteoblasts. Dentonin TFA can be used for the research of phosphate homeostasis and bone metabolism .

RXFP2 agonist 2	RXFP Receptor	Metabolic Disease
RXFP2 agonist 2 is a selective, orally active and allosteric RXFP2 agonist with an EC₅₀ value of 0.38 μM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis .

Schnurri-3 inhibitor-1	Zinc Finger Protein	Others
Schnurri-3 inhibitor-1 is a potent schnurri-3 inhibitor which is an essential regulator of adult bone formation. Schnurri-3 inhibitor-1 can inhibit Shn3 with EF1alpha promoter in osteoblast cell line Shn3FFL with an AC₅₀ value of 2.09 μM. Schnurri-3 inhibitor-1 can be used to research osteoporosis .

Arochlor 1254	Reactive Oxygen Species	Neurological Disease Metabolic Disease
Arochlor 1254 is a polychlorinated biphenyl (PCB) mixture with biphenyl and 54% chlorine. Aroclor 1254 reduced cell viability and induced overproduction of intracellular reactive oxygen species in a dose-dependent manner. Arochlor 1254 exposure reduces calcium homeostasis, osteoblast differentiation and bone formation .

Muramyl dipeptide 4 Publications Verification MDP	p38 MAPK NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist .

Cajanin	Tyrosinase	Others
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis .

Asperosaponin VI 2 Publications Verification	Caspase Apoptosis PERK p38 MAPK Akt HIF/HIF Prolyl-Hydroxylase PPAR	Cardiovascular Disease Neurological Disease
Asperosaponin VI is a saponin component from Dipsacus asper. Asperosaponin VI induces osteoblast differentiation through the BMP-2/p38 and ERK1/2 signaling pathways. Asperosaponin VI protects against hypoxia-induced cardiomyocyte apoptosis by activating the PI3K/Akt and CREB pathways. Additionally, Asperosaponin VI also has antidepressant and wound-healing-promoting activities .

ODN BW001 sodium	CDK	Inflammation/Immunology
ODN BW001 sodium is an oligodeoxynucleotide (ODN). ODN BW001 sodium plays a regulatory role in the proliferation and activation of osteoblast .

ODN BW001	CDK	Inflammation/Immunology
ODN BW001 is an oligodeoxynucleotide (ODN). ODN BW001 plays a regulatory role in the proliferation and activation of osteoblast .

[Nle8,18,Tyr34]-pTH (3-34) amide (human) [Nle8'18,Tyr34]hPTH (3-34) amide	PTHR	Endocrinology
[Nle8,18,Tyr34]-pTH (3-34) amide human ([Nle8,18,Tyr34]hPTH (3-34) amide) is a parathyroid hormone (PTH) analog .

ABD-350	NF-κB	Others
ABD-350 is an antiresorptive agent that inhibits osteoclast activity without affecting osteoblast activity and preventing ovariectomy-induced bone loss. ABD-350 inhibits NF-κB ligand-induced inhibitor of NF-κB phosphorylation, leading to osteoclast apoptosis, but has no inhibitory effect on osteoblast function, effectively preventing bone loss in ovariectomized mice, and does not inhibit parathyroid hormone-induced bone formation.

CXM102	Autophagy	Metabolic Disease
CXM102 is an autophagy activator. CXM102 can induce autophagy in aged BMSCs, leading to the rejuvenation of BMSCs and preferential differentiation into osteoblasts. CXM102 promotes the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. CXM102 can stimulate bone synthesis metabolism in middle-aged male mice, reduce bone marrow adipocytes, delay bone loss, lower serum inflammation levels, decrease organ fibrosis, and extend the lifespan of the mice .

Guaiacin	Phosphatase	Metabolic Disease
Guaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation .

Coelogin	ERK Akt	Others
Coelogin is an orally active osteoprotective agent which activates the ER-Erk and Akt-dependent signaling pathways that stimulate the osteoblastogenesis in osteoblast cells. Coelogin can be utilized in osteoporosis research .

Astragaloside I Astrasieversianin IV; Cyclosieversioside B	Wnt β-catenin	Metabolic Disease
Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway .

(-)-Camphoric acid	mGluR	Metabolic Disease
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid stimulates osteoblast differentiation and induces glutamate receptor expression. Camphoric acid also significantly induced the activation of NF-κB and AP-1 .

ZK164015	Estrogen Receptor/ERR	Others
ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility.

Wnt/β-catenin agonist 3 hydrochloride	Wnt β-catenin	Others
Wnt/β-catenin agonist 3 hydrochloride is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 (compound 98) can be used for the research of osteoporosis .

26-Deoxyactein	Aryl Hydrocarbon Receptor ERK	Metabolic Disease
26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels .

DIPQUO 2 Publications Verification	Phosphatase	Metabolic Disease
DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC₅₀ of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β .

Aloin-A 5+ Cited Publications Barbaloin-A	Wnt	Cancer
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

4-IPP 5+ Cited Publications 4-Iodo-6-phenylpyrimidine	Macrophage migration inhibitory factor (MIF)	Metabolic Disease
4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF) .

Aloin-A (Standard) Barbaloin-A (Standard)	Wnt	Cancer
Aloin (Standard) is the analytical standard of Aloin. This product is intended for research and analytical applications. Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

Glycitin 2 Publications Verification Glycitein 7-O-β-glucoside	Bacterial	Infection Cancer
Glycitin (Glycitein 7-O-β-glucoside) is a natural isoflavone with antibacterial, antiviral, anticancer, anti-inflammation, anti-aging and estrogenic effects. Glycitin may regulate osteoblasts through TGF-β or AKT signaling pathways in bone marrow stem cells (BMSCs) .

Astragaloside I (Standard)	Wnt β-catenin	Metabolic Disease
Astragaloside I (Standard) is the analytical standard of Astragaloside I. This product is intended for research and analytical applications. Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway .

Nitroprusside disodium dihydrate 5+ Cited Publications Sodium nitroprusside dihydrate; Sodium Nitroferricyanide(III) Dihydrate	Autophagy	Cardiovascular Disease Cancer
Nitroprusside disodium dehydrate (Sodium nitroprusside dihydrate) is a vasodilator that available for the research of acute hypertension, heart failure. Nitroprusside disodium dehydrate induces autophagy in glutathione-depleted osteoblasts. Nitroprusside disodium dehydrate acts as a nitric oxide (NO) donor in a rat intestinal ischemia reperfusion model .

Preptin (rat)	DNA/RNA Synthesis	Metabolic Disease
Preptin, an osteogenic peptide product of the pancreatic beta-cell, corresponds to Asp ⁶⁹-Leu ¹⁰² of pro-IGF-II .

Cat. No.	Product Name

HY-L131

Osteogenesis Compound Library

664 compounds

Ossification is a tightly regulated process, performed by specialized cells called osteoblasts. Dysregulation of this process may cause inadequate or excessive mineralization of bones or ectopic calcification, all of which have grave consequences for human health.

Osteoblasts play important roles in the process of osteogenesis and prevention of osteonecrosis. Osteoblast formation and bone formation are regulated by hormones, growth factors, cytokines, etc.

MCE offers a unique collection of 664 bone formation compounds with identified and potential inducing osteogenesis activity. MCE bone formation compound library is a useful tool for the study of bone disease drugs and pharmacology.

Cat. No.	Product Name	Type

HY-D2132

Sulfo-Cy5.5-ALN	Fluorescent Dyes/Probes
Sulfo-Cy5.5-ALN is a fluorescent labeled alendronate, which targets bone. Sulfo-Cy5.5-ALN binds to hydroxyapatite and differentiated osteoblasts in vitro. Sulfo-Cy5.5-ALN selectively binds to the mineralized areas of the tumor. Sulfo-Cy5.5-ALN can be used to detect bone overgrowth in prostate bone metastasis .

Cat. No.	Product Name	Target	Research Area

HY-P2633

Dentonin AC-100	Peptides	Metabolic Disease
Dentonin (AC-100) is a synthetic fragment derived from MEPE. Dentonin enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin has no significant effect to mature osteoblasts. Dentonin can be used for the research of phosphate homeostasis and bone metabolism .

HY-P1349A

Orexin B, rat, mouse TFA Rat orexin B TFA; Orexin B (mouse) TFA	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation .

HY-P1349

Orexin B, rat, mouse Rat orexin B; Orexin B (mouse)	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-P0254A

Kisspeptin-10, human TFA	Kisspeptin Receptor	Cardiovascular Disease Cancer
Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression .

HY-P4794

Osteoblast-Adhesive Peptide	Peptides	Others
Osteoblast-Adhesive Peptide is a polypeptide used for chemical modification of biomaterials. Osteoclast Adaptive Peptide increases the adhesion of osteoblasts and has potential applications in dentistry and orthopedics .

HY-P5929

VnP-16	Integrin FAK	Inflammation/Immunology
VnP-16 can promote bone formation by accelerating osteoblast differentiation and activity through direct interaction with β1 integrin followed by FAK activation .

HY-P2633A

Dentonin TFA AC-100 TFA	Integrin	Metabolic Disease
Dentonin TFA (AC-100 TFA) is a synthetic fragment derived from MEPE. Dentonin TFA enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin TFA has no significant effect to mature osteoblasts. Dentonin TFA can be used for the research of phosphate homeostasis and bone metabolism .

HY-P10309

[Nle8,18,Tyr34]-pTH (3-34) amide (human) [Nle8'18,Tyr34]hPTH (3-34) amide	PTHR	Endocrinology
[Nle8,18,Tyr34]-pTH (3-34) amide human ([Nle8,18,Tyr34]hPTH (3-34) amide) is a parathyroid hormone (PTH) analog .

HY-P4587

(Glu13,17,20)-Osteocalcin (1-46) (mouse)	Peptides	Metabolic Disease
(Glu13,17,20)-Osteocalcin (1-46) (mouse) is an analogue of Osteocalcin (1-46). Osteocalcin (1-46) is a osteoblast specific peptide involved in the regulation of energy metabolism .

HY-P4813

Preptin (rat)	DNA/RNA Synthesis	Metabolic Disease
Preptin, an osteogenic peptide product of the pancreatic beta-cell, corresponds to Asp ⁶⁹-Leu ¹⁰² of pro-IGF-II .

HY-P0254

Kisspeptin-10, human	Kisspeptin Receptor	Cardiovascular Disease Cancer
Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression .

HY-P5284

RALA peptide	Peptides	Others
RALA peptide is a cationic amphiphilic delivery agent targeting cell membranes, which forms nanoparticles through electrostatic interactions with anionic drugs. RALA peptide has pH-responsive binding properties, which can enhance the α-helical conformation in an acidic environment and destroy the endosomal membrane, promote the release of drugs into the cytoplasm, and exert efficient intracellular delivery activity. RALA peptide can be used in cancer research (enhancing the activity of bisphosphonates against prostate cancer and breast cancer cells) and bone tissue engineering (promoting osteoblast collagen deposition and extracellular matrix mineralization) .

HY-P1252

Parathyroid Hormone (1-34), bovine 1 Publications Verification	Thyroid Hormone Receptor	Metabolic Disease
Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis .

HY-P1252A

Parathyroid Hormone (1-34), bovine TFA	Thyroid Hormone Receptor	Metabolic Disease
Parathyroid Hormone (1-34), bovine TFA is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis .

Species:	Human (6) Rat (1) Mouse (2)
Tag:	His (9) Myc (1)
Source:	HEK293 (7) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P79348

	Periostin/OSF-2 Protein, Rat (HEK293, His) Periostin; Periostin, osteoblast specific factor (Predicted), isoform CRA_a; Postn; Postn_predicted; osteoblast Specific Factor 2	Rat	HEK293
	Periostin/OSF-2 Protein, a multifaceted regulator, induces cell attachment and spreading, participates in cell adhesion, and enhances BMP1 incorporation into the fibronectin matrix. It forms a structural homodimer and interacts with BMP1 and fibronectin. This interplay positions Periostin as a key player in regulating cellular and tissue functions, including cell adhesion, tissue architecture, and extracellular matrix modulation. Periostin/OSF-2 Protein, Rat (HEK293, His) is the recombinant rat-derived Periostin/OSF-2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73373

	Periostin Protein, Mouse (HEK293, His) osteoblast-specific factor 2; OSF-2; POSTN; Periostin	Mouse	HEK293
	Periostin protein is a multifunctional molecule that plays a key role in cellular processes by inducing cell attachment and spreading, emphasizing its importance in cell adhesion dynamics. Furthermore, Periostin contributes to the structural integrity of connective tissue by enhancing the binding of BMP1 to the fibronectin matrix and promoting subsequent proteolytic activation of lysyl oxidase LOX. Periostin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Periostin protein, expressed by HEK293 , with C-His labeled tag.

HY-P71196

	Periostin Protein, Human (758a.a, HEK293, His) osteoblast-specific factor 2; OSF-2; POSTN; Periostin	Human	HEK293
	Periostin protein, a multifaceted regulator, induces cell attachment and spreading, participates in cell adhesion, and enhances BMP1 incorporation into the fibronectin matrix. It forms a structural homodimer and interacts with BMP1 and fibronectin. This interplay positions Periostin as a key player in regulating cellular and tissue functions, including cell adhesion, tissue architecture, and extracellular matrix modulation. Periostin Protein, Human (758a.a, HEK293, His) is the recombinant human-derived Periostin protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74638

	Periostin Protein, Human (781a.a, HEK293, His) osteoblast-specific factor 2; OSF-2; POSTN; Periostin	Human	HEK293
	Periostin (POSTN) is a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. POSTN binds to integrins and BMP1 to support cell adhesion, cell migration and the structural integrity of connective tissues. Periostin Protein, Human (781a.a, HEK293, His) is the recombinant human-derived Periostin protein, expressed by HEK293 , with C-His labeled tag.

HY-P7698

	Cadherin-11 Protein, Human (HEK293, His) rHuCadherin-11, His; Cadherin 11 Type 2 OB-cadherin (osteoblast); CDH11; Cadherin-11	Human	HEK293
	Cadherin-11 Protein, Human (HEK293, His) is a recombinant human Cadherin-11 produced in HEK293 cells, with His tag. Cadherin-11 is a classical cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion.

HY-P71213

	Pleiotrophin Protein, Mouse (HEK293, His) 2 Publications Verification Pleiotrophin; PTN; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; osteoblast-specific factor 1; OSF-1;	Mouse	HEK293
	Pleiotrophin (PTN) is a secreted growth factor that transduces signals through cell surface proteoglycan and non-proteoglycan receptors.PTN binds to chondroitin sulfate (CS) groups and regulates cell proliferation, survival, and differentiation, particularly inhibiting long-term synaptic potentiation of neurons.Pleiotrophin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Pleiotrophin protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71448

	ITGBL1 Protein, Human (Myc, His) ITGBL1; OSCP; TIED; Integrin beta-like protein 1; osteoblast-specific cysteine-rich protein; Ten integrin EGF-like repeat domain-containing protein	Human	E. coli
	Integrin beta-like protein 1 (ITGBL1) is a beta integrin-related protein that is a member of the EGF-like protein family, containing integrin-like cysteine-rich repeats and may has integrin binding activity. ITGBL1 might be involved in cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. ITGBL1 Protein, Human (Myc, His) is the recombinant human-derived ITGBL1 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

HY-P704155

	TMEM119 Protein, Human (P. pastoris, His) TMEM119; Transmembrane protein 119; osteoblast induction factor (OBIF)	Human	P. pastoris

HY-P77628

	Cadherin-11 Protein, Human (564a.a, HEK293, His) Cadherin-11; OSF-4; osteoblast cadherin; OB-cadherin; CDH11; CAD11OSF-4; CDHOB; OB	Human	HEK293
	Cadherin-11, a calcium-dependent cell adhesion protein, belongs to the cadherin family. Cadherin-11 Protein, Human (564a.a, HEK293, His) is the recombinant human-derived Cadherin-11 protein, expressed by HEK293 , with C-His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-W014839S

Cyclamic acid-d11 sodium

Cyclamic acid-d₁₁ (Sodium cyclamate-d₁₁) sodiumis deuterium labeled Cyclamic acid (sodium). Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81535

	Periostin Antibody (YA1280) Fasciclin-I like; OSF2; Periostin; Periostin osteoblast specific factor; PN; POSTN; RP11 412K4.1	IHC-P	Human
	Periostin Antibody (YA1280) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1280), targeting Periostin. Periostin Antibody (YA1280) can be used for IHC-P experiment in human background.

HY-P82028

	PTN Antibody (YA1773) PTN; HBNF1; NEGF1; Pleiotrophin; PTN; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; osteoblast-specific factor 1; OSF-1	WB, IP	Human, Rat
	PTN Antibody (YA1773) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1773), targeting PTN, with a predicted molecular weight of 19 kDa (observed band size: 19 kDa). PTN Antibody (YA1773) can be used for WB, IP experiment in human, rat background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-W014839

Cyclamic acid sodium Sodium cyclamate; Cyclohexylsulfamic acid sodium		Sweetening Agents
Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

HY-150213A

ODN BW001 sodium		CpG ODNs
ODN BW001 sodium is an oligodeoxynucleotide (ODN). ODN BW001 sodium plays a regulatory role in the proliferation and activation of osteoblast .

HY-150213

ODN BW001		CpG ODNs
ODN BW001 is an oligodeoxynucleotide (ODN). ODN BW001 plays a regulatory role in the proliferation and activation of osteoblast .

HY-150214

ODN MT01		CpG ODNs
ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

HY-150214A

ODN MT 01 sodium		CpG ODNs
ODN MT01 sodium was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 sodium could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks