RUNX2 Antibody (YA6091)

RUNX2 Antibody (YA6091) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RUNX2. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

RUNX2 is a transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. It is essential for osteoblast maturation as well as both intramembranous and endochondral ossification. CBF binds to the core site 5'-PYGPYGGT-3' of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3, and GM-CSF promoters. In osteoblasts, RUNX2 supports transcriptional activation by synergizing with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (by similarity). It also inhibits KAT6B-dependent transcriptional activation.

Q13950

Predicted band size: 57 kDa; Observed band size: 57 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

Human, Mouse, Rat

IHC: 1:1000-1:5000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, IHC-P, ICC/IF, IP, ELISA

WB, IHC-P, ICC/IF

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG