WAY-362692 

WAY-362692 is a secreted frizzled-related protein (sFRP-1) inhibitor (IC₅₀ of 0.02 μM), targeting the netrin domain of sFRP-1. WAY-362692 can competitively inhibit the interaction between sFRP-1 and Wnt proteins, and activate the Wnt/β-catenin signaling pathway (EC₅₀ = 0.03 μM). WAY-362692 can activate osteoblasts and promote bone remodeling. WAY-362692 can be used for the research of metabolic disease, such as osteoporosis^[1].

WAY-362692 (Compound 7b) (0.1-1 nM, 7 days) induces osteoblast activation and bone remodeling and increases the total bone area of 4-day-old neonatal mouse calvariae^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

644.73

C₂₈H₃₅F₃N₄O₆S₂

915763-27-8

O=C(N1[C@H](C(N2CCC(NS(=O)(C3=CC(S(=O)(C4=CC=CC=C4)=O)=CC=C3C(F)(F)F)=O)CC2)=O)CCC1)NC(C)(C)C

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem. 2009 Jan 8;52(1):105-16.  [Content Brief]