2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. ZK164015

ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility.

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ZK164015

ZK164015 Chemical Structure

CAS No. : 177583-70-9

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Based on 1 publication(s) in Google Scholar

ZK164015 Related Antibodies

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View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility.

Molecular Weight

513.73

Formula

C30H43NO4S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC2=C(N(CCCCCCCCCCS(=O)(CCCCC)=O)C(C3=CC=C(O)C=C3)=C2C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (194.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9465 mL 9.7327 mL 19.4655 mL
5 mM 0.3893 mL 1.9465 mL 3.8931 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9465 mL 9.7327 mL 19.4655 mL 48.6637 mL
5 mM 0.3893 mL 1.9465 mL 3.8931 mL 9.7327 mL
10 mM 0.1947 mL 0.9733 mL 1.9465 mL 4.8664 mL
15 mM 0.1298 mL 0.6488 mL 1.2977 mL 3.2442 mL
20 mM 0.0973 mL 0.4866 mL 0.9733 mL 2.4332 mL
25 mM 0.0779 mL 0.3893 mL 0.7786 mL 1.9465 mL
30 mM 0.0649 mL 0.3244 mL 0.6488 mL 1.6221 mL
40 mM 0.0487 mL 0.2433 mL 0.4866 mL 1.2166 mL
50 mM 0.0389 mL 0.1947 mL 0.3893 mL 0.9733 mL
60 mM 0.0324 mL 0.1622 mL 0.3244 mL 0.8111 mL
80 mM 0.0243 mL 0.1217 mL 0.2433 mL 0.6083 mL
100 mM 0.0195 mL 0.0973 mL 0.1947 mL 0.4866 mL
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ZK164015 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZK164015177583-70-9ZK 164015ZK-164015Estrogen Receptor/ERRInhibitorinhibitorinhibit

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